13 results on '"Lorenzo, Mellini"'
Search Results
2. The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions
- Author
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Giacomo Feliciani, Lorenzo Mellini, Aldo Carnevale, Anna Sarnelli, Enrico Menghi, Filippo Piccinini, Emanuela Scarpi, Emiliano Loi, Roberto Galeotti, Melchiore Giganti, and Gian Carlo Parenti
- Subjects
Medicine ,Science - Abstract
Abstract How to differentiate with MRI-based techniques testicular germ (TGCTs) and testicular non-germ cell tumors (TNGCTs) is still under debate and Radiomics may be the turning key. Our purpose is to investigate the performance of MRI-based Radiomics signatures for the preoperative prediction of testicular neoplasm histology. The aim is twofold: (i), differentiating TGCTs and TNGCTs status and (ii) differentiating seminomas (SGCTs) from non-seminomatous (NSGCTs). Forty-two patients with pathology-proven testicular neoplasms and referred for pre-treatment MRI, were retrospectively enrolled. Thirty-two out of 44 lesions were TGCTs. Twelve out of 44 were TNGCTs or other histologies. Two radiologists segmented the volume of interest on T2-weighted images. Approximately 500 imaging features were extracted. Least Absolute Shrinkage and Selection Operator (LASSO) was applied as method for variable selection. A linear model and a linear support vector machine (SVM) were trained with selected features to assess discrimination scores for the two endpoints. LASSO identified 3 features that were employed to build fivefold validated linear discriminant and linear SVM classifiers for the TGCT-TNGCT endpoint giving an overall accuracy of 89%. Four features were employed to build another SVM for the SGCT-SNGCT endpoint with an overall accuracy of 86%. The data obtained proved that T2-weighted-based Radiomics is a promising tool in the diagnostic workup of testicular neoplasms by discriminating germ cell from non-gem cell tumors, and seminomas from non-seminomas.
- Published
- 2021
- Full Text
- View/download PDF
3. Consensus based recommendations for diagnosis and medical management of Poland syndrome (sequence)
- Author
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Ilaria Baldelli, Alessio Baccarani, Chiara Barone, Francesca Bedeschi, Sebastiano Bianca, Olga Calabrese, Marco Castori, Nunzio Catena, Massimo Corain, Sara Costanzo, Giacomo De Paoli Barbato, Santa De Stefano, Maria Teresa Divizia, Francesco Feletti, Matteo Formica, Mario Lando, Margherita Lerone, Fulvio Lorenzetti, Carlo Martinoli, Lorenzo Mellini, Maurizio Bruno Nava, Giuseppe Porcellini, Aldamaria Puliti, Maria Victoria Romanini, Franco Rondoni, Pierluigi Santi, Silvana Sartini, Filippo Senes, Lucia Spada, Luigi Tarani, Maura Valle, Cristina Venturino, Federico Zaottini, Michele Torre, and Marco Crimi
- Subjects
Poland syndrome ,Best practice recommendations ,Diagnosis ,Rare diseases ,Clinical management ,Medicine - Abstract
Abstract Background Poland syndrome (OMIM: 173800) is a disorder in which affected individuals are born with missing or underdeveloped muscles on one side of the body, resulting in abnormalities that can affect the chest, breast, shoulder, arm, and hand. The extent and severity of the abnormalities vary among affected individuals. Main body The aim of this work is to provide recommendations for the diagnosis and management of people affected by Poland syndrome based on evidence from literature and experience of health professionals from different medical backgrounds who have followed for several years affected subjects. The literature search was performed in the second half of 2019. Original papers, meta-analyses, reviews, books and guidelines were reviewed and final recommendations were reached by consensus. Conclusion Being Poland syndrome a rare syndrome most recommendations here presented are good clinical practice based on the consensus of the participant experts.
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- 2020
- Full Text
- View/download PDF
4. Experiences of patients with Poland syndrome of diagnosis and care in Italy: a pilot survey
- Author
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Ilaria Baldelli, Fabio Gallo, Marco Crimi, Piero Fregatti, Lorenzo Mellini, Pierluigi Santi, and Rosagemma Ciliberti
- Subjects
Poland syndrome ,Breast asymmetry ,Chest malformation ,Hand malformation ,Congenital malformation ,Rare disease ,Medicine - Abstract
Abstract Background Poland Syndrome (PS) is a rare congenital malformation involving functional and aesthetic impairments. Early diagnosis and timely therapeutic approaches play an important role in improving the quality of life of patients and kindred. This study aims to explore healthcare experiences of the diagnosis of patients affected by PS and to investigate the factors associated with diagnostic delay in Italy. Results Seventy-two patients affected by PS were asked to fill in a self- administered questionnaire on: a) diagnostic path; b) perceived quality of care received after diagnosis; c) knowledge of the rights and the socio-economic hardships related to their disease; d) evaluation of the integration of various professional skills involved in the diagnostic and therapeutic approach; e) perception of the social support provided by the Italian Association of Poland Syndrome (AISP). The average age at diagnosis was around 14 years; diagnosis was made at birth in only 31.58% of cases. Although typical symptomatology had appeared on average at an early age (4 months), only 23 patients (40.35%) received an early diagnosis (within the first year of life). Just over half of the patients (n = 30) were diagnosed in their region of origin, while 27 were diagnosed elsewhere. Furthermore, 12.28% were self-diagnoses. Among the patients who were diagnosed outside their region, 15 (88.24%) stated they had foregone some visits or treatments owing to costs and/or organizational issues. Conclusions An analysis of the patients’ experiences highlights several gaps and a lack of homogeneity in the diagnostic and therapeutic follow-up of PS patients in Italy. A specific national diagnostic and therapeutic path is essential to guarantee patients complete and appropriate health services, compliant with the ethical principles of non-discrimination, justice and empathy. Implementation of an effective information and research network and empowerment of patients’ associations are necessary conditions to encourage clinical collaboration and improve the quality of life of people living with rare diseases.
- Published
- 2019
- Full Text
- View/download PDF
5. Injuries in Medium to Long-Distance Triathlon: A Retrospective Analysis of Medical Conditions Treated in Three Editions of the Ironman Competition
- Author
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Francesco, Feletti, Gaia, Saini, Stefano, Naldi, Carlo, Casadio, Lorenzo, Mellini, Giacomo, Feliciani, and Emanuela, Zamprogno
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Male ,muscle cramp ,Physical Therapy, Sports Therapy and Rehabilitation ,Bicycling ,wounds ,GV557-1198.995 ,Sports medicine ,running ,Humans ,Female ,imaging diagnostics ,Orthopedics and Sports Medicine ,swimming ,RC1200-1245 ,Retrospective Studies ,Research Article ,injuries ,Sports - Abstract
Triathlon’s popularity is rapidly increasing, and epidemiological data relating to its related medical conditions is crucial to the development of proper medical plans and safety guidelines for it. This study examined the data from the medical reports collected during three consecutive editions of Ironman Italy, from 2017 to 2019. Out of 10,653 race-starters, 3.3% required medical attention sustaining 472 medical conditions. A significantly higher injury risk was found for females versus males (χ2 = 9.78, p = 0.02) and in long-distance (IR: 4.09/1,000hours) rather than in Olympic/middle distance races (IR: 1.75/1,000hours). Most (68.4%) conditions (including muscular exhaustion, hypothermia, and dehydration) were systemic, whilst only 10.2% were acute traumatic injuries. Of a total of 357 triathletes requiring medical assistance, 8.1% were a candidate for hospitalisation. The equipment and personnel that are required for the medical assistance in future triathlon events were estimated based on Maurer’s algorithm, and ten practical recommendations for triathlon medical support were formulated.
- Published
- 2021
6. The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions
- Author
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Gian Carlo Parenti, Emiliano Loi, Emanuela Scarpi, Melchiore Giganti, Aldo Carnevale, Roberto Galeotti, Anna Sarnelli, Giacomo Feliciani, E. Menghi, Filippo Piccinini, Lorenzo Mellini, Feliciani G., Mellini L., Carnevale A., Sarnelli A., Menghi E., Piccinini F., Scarpi E., Loi E., Galeotti R., Giganti M., and Parenti G.C.
- Subjects
Adult ,Male ,medicine.medical_specialty ,endocrine system ,Support Vector Machine ,endocrine system diseases ,Science ,Testicular Neoplasm ,Feature selection ,Article ,NO ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Lasso (statistics) ,Testicular cancer ,Testicular Neoplasms ,Retrospective Studie ,medicine ,radiomic biomarkers ,Humans ,testicular lesions, radiomic biomarkers, MR ,Retrospective Studies ,Multidisciplinary ,business.industry ,Biomarker ,MR ,Neoplasms, Germ Cell and Embryonal ,medicine.disease ,Linear discriminant analysis ,testicular lesions ,Magnetic Resonance Imaging ,Seminoma ,Support vector machine ,030220 oncology & carcinogenesis ,Medicine ,Cancer imaging ,Radiology ,business ,Selection operator ,Biomarkers ,Human - Abstract
How to differentiate with MRI-based techniques testicular germ (TGCTs) and testicular non-germ cell tumors (TNGCTs) is still under debate and Radiomics may be the turning key. Our purpose is to investigate the performance of MRI-based Radiomics signatures for the preoperative prediction of testicular neoplasm histology. The aim is twofold: (i), differentiating TGCTs and TNGCTs status and (ii) differentiating seminomas (SGCTs) from non-seminomatous (NSGCTs). Forty-two patients with pathology-proven testicular neoplasms and referred for pre-treatment MRI, were retrospectively enrolled. Thirty-two out of 44 lesions were TGCTs. Twelve out of 44 were TNGCTs or other histologies. Two radiologists segmented the volume of interest on T2-weighted images. Approximately 500 imaging features were extracted. Least Absolute Shrinkage and Selection Operator (LASSO) was applied as method for variable selection. A linear model and a linear support vector machine (SVM) were trained with selected features to assess discrimination scores for the two endpoints. LASSO identified 3 features that were employed to build fivefold validated linear discriminant and linear SVM classifiers for the TGCT-TNGCT endpoint giving an overall accuracy of 89%. Four features were employed to build another SVM for the SGCT-SNGCT endpoint with an overall accuracy of 86%. The data obtained proved that T2-weighted-based Radiomics is a promising tool in the diagnostic workup of testicular neoplasms by discriminating germ cell from non-gem cell tumors, and seminomas from non-seminomas.
- Published
- 2021
7. Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation
- Author
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Giorgia Dalpiaz, Lorenzo Gamberini, Aldo Carnevale, Savino Spadaro, Carlo Alberto Mazzoli, Sara Piciucchi, Davide Allegri, Chiara Capozzi, Ersenad Neziri, Maurizio Bartolucci, Francesco Muratore, Francesca Coppola, Antonio Poerio, Emanuela Giampalma, Luca Baldini, Tommaso Tonetti, Iacopo Cappellini, Davide Colombo, Gianluca Zani, Lorenzo Mellini, Vanni Agnoletti, Federica Damiani, Giovanni Gordini, Cristiana Laici, Giuliano Gola, Antonella Potalivo, Jonathan Montomoli, Vito Marco Ranieri, Emanuele Russo, Stefania Taddei, Carlo Alberto Volta, Gaetano Scaramuzzo, Dalpiaz G., Gamberini L., Carnevale A., Spadaro S., Mazzoli C.A., Piciucchi S., Allegri D., Capozzi C., Neziri E., Bartolucci M., Muratore F., Coppola F., Poerio A., Giampalma E., Baldini L., Tonetti T., Cappellini I., Colombo D., Zani G., Mellini L., Agnoletti V., Damiani F., Gordini G., Laici C., Gola G., Potalivo A., Montomoli J., Ranieri V.M., Russo E., Taddei S., Volta C.A., and Scaramuzzo G.
- Subjects
Male ,Acute respiratory distress syndrome ,SARS-CoV-2 ,Chest Radiology ,Novel coronavirus disease 2019 ,COVID-19 ,General Medicine ,Length of Stay ,Middle Aged ,Respiration, Artificial ,NO ,Intensive Care Units ,Pulmonary perfusion ,Mechanical ventilation ,Italy ,Microvessels ,Thoracic imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Prospective Studies ,Tomography, X-Ray Computed ,Lung ,Aged - Abstract
Purpose COVID-19-related acute respiratory distress syndrome (ARDS) is characterized by the presence of signs of microvascular involvement at the CT scan, such as the vascular tree in bud (TIB) and the vascular enlargement pattern (VEP). Recent evidence suggests that TIB could be associated with an increased duration of invasive mechanical ventilation (IMV) and intensive care unit (ICU) stay. The primary objective of this study was to evaluate whether microvascular involvement signs could have a prognostic significance concerning liberation from IMV. Material and methods All the COVID-19 patients requiring IMV admitted to 16 Italian ICUs and having a lung CT scan recorded within 3 days from intubation were enrolled in this secondary analysis. Radiologic, clinical and biochemical data were collected. Results A total of 139 patients affected by COVID-19 related ARDS were enrolled. After grouping based on TIB or VEP detection, we found no differences in terms of duration of IMV and mortality. Extension of VEP and TIB was significantly correlated with ground-glass opacities (GGOs) and crazy paving pattern extension. A parenchymal extent over 50% of GGO and crazy paving pattern was more frequently observed among non-survivors, while a VEP and TIB extent involving 3 or more lobes was significantly more frequent in non-responders to prone positioning. Conclusions The presence of early CT scan signs of microvascular involvement in COVID-19 patients does not appear to be associated with differences in duration of IMV and mortality. However, patients with a high extension of VEP and TIB may have a reduced oxygenation response to prone positioning. Trial Registration: NCT04411459 Supplementary Information The online version contains supplementary material available at 10.1007/s11547-021-01444-7.
- Published
- 2022
8. Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study
- Author
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Antonio Poerio, Andrea Castelli, Sara Piciucchi, Giulia Falò, Davide Allegri, Marco Verri, Andrea Marudi, Massimiliano Mazzolini, Michele Imbriani, Loredana Franchini, Carlo Coniglio, Mirco Leo, Antonella Potalivo, Luigi Lazzari Agli, Roberta Nicali, Marco Cavagnino, Guglielmo Consales, Marina Terzitta, Harri Sintonen, Raffaella Papa, Maria Teresa Minguzzi, Cristiana Laici, Paolo Orlandi, Federica Damiani, Carlo Alberto Mazzoli, Silvia Orlando, Vito Marco Ranieri, Iacopo Cappellini, Valentina Chiarini, Elisa Marinangeli, Stefano Oldani, Virginia Buldini, Marco Tartaglione, Gianluca Zani, Lorenzo Mellini, Carlo Alberto Volta, Irene Ottaviani, Silvia Candini, Filippo Becherucci, Emanuela Giampalma, Maria Concetta Lanza, Federica Ciccarese, Irene Cavalli, Annalisa Marchio, Bruno Balbi, Fabrizio Racca, Matteo Monari, Luca Morini, Anna Malfatto, Elisabetta Bertellini, Francesco Boni, Emanuele Russo, Lorenzo Viola, Michele Valli, Savino Spadaro, Martina Ferioli, Emanuele Matteo, Giovanni Gordini, Marco Contoli, Ilaria Valentini, Chiara Tartivita, Alessia Guzzo, Lorenzo Giuntoli, Gaetano Scaramuzzo, Davide Colombo, Jessica Maccieri, Luca Bissoni, Stefano Nava, Angela Bellocchio, Patrizio Goti, Laura Bernabé, Jonathan Montomoli, Stefano Maitan, Tommaso Meconi, Angelo Senzi, Lorenzo Gamberini, Silvia Pareschi, Stefania Taddei, Angelica Venni, Fabio Ferrari, Marco Miceli, Chiara Capozzi, Elisabetta Marangoni, Lorenzo Tutino, Giulia Felloni, Antonio Siniscalchi, Giacinto Pizzilli, Francesco Muratore, Giorgia Dalpiaz, Federico Moro, Daniele Fecarotti, Vanni Agnoletti, Gabriele Melegari, Rita Golfieri, Federico Domenico Baccarini, Francesca Facondini, Patrizia Pompa Cleta, Marianna Padovani, Eva Bernardi, Tommaso Tonetti, Angelina Adduci, Federico Daniele, Anna Filomena Ferravante, Maurizio Fusari, Igor Bacchilega, Claudia Ravaglia, Nicola Cilloni, Martina Mughetti, Vittorio Pavoni, Ersenad Neziri, Irene Prediletto, Aline Pagni, Gamberini L., Mazzoli C.A., Prediletto I., Sintonen H., Scaramuzzo G., Allegri D., Colombo D., Tonetti T., Zani G., Capozzi C., Dalpiaz G., Agnoletti V., Cappellini I., Melegari G., Damiani F., Fusari M., Gordini G., Laici C., Lanza M.C., Leo M., Marudi A., Papa R., Potalivo A., Montomoli J., Taddei S., Mazzolini M., Ferravante A.F., Nicali R., Ranieri V.M., Russo E., Volta C.A., Spadaro S., Tartaglione M., Chiarini V., Buldini V., Coniglio C., Moro F., Orlando S., Fecarotti D., Cilloni N., Giuntoli L., Bellocchio A., Matteo E., Pizzilli G., Siniscalchi A., Tartivita C., Cavalli I., Castelli A., Marchio A., Bacchilega I., Bernabe L., Facondini F., Morini L., Bissoni L., Viola L., Meconi T., Pavoni V., Venni A., Pagni A., Cleta P.P., Cavagnino M., Guzzo A., Malfatto A., Adduci A., Pareschi S., Bertellini E., Maccieri J., Marinangeli E., Racca F., Verri M., Falo G., Marangoni E., Ottaviani I., Boni F., Felloni G., Baccarini F.D., Terzitta M., Maitan S., Tutino L., Senzi A., Consales G., Becherucci F., Imbriani M., Orlandi P., Candini S., Golfieri R., Ciccarese F., Poerio A., Muratore F., Ferrari F., Mughetti M., Giampalma E., Franchini L., Neziri E., Miceli M., Minguzzi M.T., Mellini L., Piciucchi S., Monari M., Valli M., Daniele F., Ferioli M., Nava S., Lazzari Agli L.A., Valentini I., Bernardi E., Balbi B., Contoli M., Padovani M., Oldani S., Ravaglia C., and Goti P.
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,medicine.medical_treatment ,Health-related quality of life ,Population ,Article ,NO ,Pulmonary function testing ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,DLCO ,Acute respiratory distress syndrome ,COVID-19 ,Dyspnea ,Respiratory function tests ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Survivors ,education ,Aged ,Mechanical ventilation ,Health related quality of life ,education.field_of_study ,Respiratory Distress Syndrome ,business.industry ,Middle Aged ,Respiration, Artificial ,Patient Discharge ,humanities ,3. Good health ,Intensive Care Units ,030228 respiratory system ,Italy ,Quality of Life ,Female ,business ,Icu discharge ,Follow-Up Studies - Abstract
Background Health-related quality of life (HRQoL) impairment is often reported among COVID-19 ICU survivors, and little is known about their long-term outcomes. We evaluated the HRQoL trajectories between 3 months and 1 year after ICU discharge, the factors influencing these trajectories and the presence of clusters of HRQoL profiles in a population of COVID-19 patients who underwent invasive mechanical ventilation (IMV). Moreover, pathophysiological correlations of residual dyspnea were tested. Methods We followed up 178 survivors from 16 Italian ICUs up to one year after ICU discharge. HRQoL was investigated through the 15D instrument. Available pulmonary function tests (PFTs) and chest CT scans at 1 year were also collected. A linear mixed-effects model was adopted to identify factors associated with different HRQoL trajectories and a two-step cluster analysis was performed to identify HRQoL clusters. Results We found that HRQoL increased during the study period, especially for the significant increase of the physical dimensions, while the mental dimensions and dyspnea remained substantially unchanged. Four main 15D profiles were identified: full recovery (47.2%), bad recovery (5.1%) and two partial recovery clusters with mostly physical (9.6%) or mental (38.2%) dimensions affected. Gender, duration of IMV and number of comorbidities significantly influenced HRQoL trajectories. Persistent dyspnea was reported in 58.4% of patients, and weakly, but significantly, correlated with both DLCO and length of IMV. Conclusions HRQoL impairment is frequent 1 year after ICU discharge, and the lowest recovery is found in the mental dimensions. Persistent dyspnea is often reported and weakly correlated with PFTs alterations. Trial registration NCT04411459.
- Published
- 2021
9. Experiences of patients with Poland syndrome of diagnosis and care in Italy: A pilot survey
- Author
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Marco Crimi, Pierluigi Santi, Ilaria Baldelli, Lorenzo Mellini, Piero Fregatti, Fabio Gallo, and Rosagemma Ciliberti
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Poland syndrome ,media_common.quotation_subject ,lcsh:Medicine ,Empathy ,Pilot Projects ,Disease ,Therapeutic approach ,Social support ,Young Adult ,Surveys and Questionnaires ,Health care ,medicine ,Humans ,Pharmacology (medical) ,Underdiagnosed patients ,Empowerment ,Child ,Genetics (clinical) ,media_common ,business.industry ,Research ,lcsh:R ,Hand malformation ,Breast asymmetry ,Chest malformation ,Congenital malformation ,Rare disease ,General Medicine ,medicine.disease ,Logistic Models ,Italy ,Family medicine ,Female ,business - Abstract
Background Poland Syndrome (PS) is a rare congenital malformation involving functional and aesthetic impairments. Early diagnosis and timely therapeutic approaches play an important role in improving the quality of life of patients and kindred. This study aims to explore healthcare experiences of the diagnosis of patients affected by PS and to investigate the factors associated with diagnostic delay in Italy. Results Seventy-two patients affected by PS were asked to fill in a self- administered questionnaire on: a) diagnostic path; b) perceived quality of care received after diagnosis; c) knowledge of the rights and the socio-economic hardships related to their disease; d) evaluation of the integration of various professional skills involved in the diagnostic and therapeutic approach; e) perception of the social support provided by the Italian Association of Poland Syndrome (AISP). The average age at diagnosis was around 14 years; diagnosis was made at birth in only 31.58% of cases. Although typical symptomatology had appeared on average at an early age (4 months), only 23 patients (40.35%) received an early diagnosis (within the first year of life). Just over half of the patients (n = 30) were diagnosed in their region of origin, while 27 were diagnosed elsewhere. Furthermore, 12.28% were self-diagnoses. Among the patients who were diagnosed outside their region, 15 (88.24%) stated they had foregone some visits or treatments owing to costs and/or organizational issues. Conclusions An analysis of the patients’ experiences highlights several gaps and a lack of homogeneity in the diagnostic and therapeutic follow-up of PS patients in Italy. A specific national diagnostic and therapeutic path is essential to guarantee patients complete and appropriate health services, compliant with the ethical principles of non-discrimination, justice and empathy. Implementation of an effective information and research network and empowerment of patients’ associations are necessary conditions to encourage clinical collaboration and improve the quality of life of people living with rare diseases.
- Published
- 2019
10. Design and production of custom-made prosthetic implants in pectoral reconstruction in patients with Poland Syndrome using integrated CAD/CAM systems
- Author
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Pierluigi Santi, Lorenzo Mellini, Alex Rovina, Rosella Ciliberti, and Ilaria Baldelli
- Subjects
business.industry ,Poland syndrome ,medicine ,Prosthetic implants ,Dentistry ,In patient ,CAD ,business ,medicine.disease - Abstract
"Poland Syndrome is a rare congenital condition characterized by deformities affecting soft and skeletal tissues of thorax and ipsilateral upper limb. Psychophysical integrity, especially for young people, is influenced by early diagnosis and an effective therapeutic strategy. Reconstructive surgery is the gold standard treatment and developing custom-made implants could dramatically change the outcomes for those patients."
- Published
- 2019
11. The role of alexithymia in predicting incident depression in patients at first acute coronary syndrome
- Author
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Diego Ardissino, Matteo Tonna, Carlo Marchesi, Chiara De Panfilis, Francesca Scagnelli, Lorenzo Mellini, and Paolo Ossola
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,lcsh:RC435-571 ,Hospital Anxiety and Depression Scale ,Toronto Alexithymia Scale ,Alexithymia ,Risk Factors ,Internal medicine ,lcsh:Psychiatry ,Acute Coronary Syndrome ,Affective Symptoms ,Aged ,Depression ,Female ,Humans ,Middle Aged ,Proportional Hazards Models ,Psychiatric Status Rating Scales ,Regression Analysis ,Clinical Psychology ,Psychiatry and Mental Health ,medicine ,In patient ,Risk factor ,Psychiatry ,Depression (differential diagnoses) ,medicine.diagnostic_test ,Proportional hazards model ,medicine.disease ,Psychiatry and Mental health ,Psychology - Abstract
Objective Alexithymia has been considered both to predispose to depression and to worsen cardiac prognosis after an acute coronary syndrome. Nonetheless, no studies have evaluated its role as a risk factor for incident depression, in patients with acute coronary syndrome. Methods In 251 consecutive patients, the presence of a first-ever depressive episode was evaluated with the Primary Care Evaluation of Mental Disorders at baseline and 1, 2, 4, 6, 9, 12 and 24 months after their first acute coronary syndrome. At baseline, patients completed the Toronto Alexithymia Scale (TAS-20) and the Hospital Anxiety and Depression Scale. Results Out of 251 subjects (80.9% males), a first-ever depressive episode was diagnosed in 66 patients. Depressed and never-depressed patients differed in female gender, living status, alexithymic scores at TAS-20 and depressive symptoms. Nonetheless, nor the TAS-20 factors nor its total score were predictive of developing a depressive episode in a Cox regression. Moreover, baseline differences in TAS-20 scores between the two groups, disappeared after controlling for anhedonic symptoms. Conclusion Our results do not support the hypothesis that alexithymia at TAS-20 is a risk factor for incident depression after acute coronary syndrome.
- Published
- 2015
12. Metabolic side effects of second generation antipsychotic agents in antipsychotic-naïve patients: one-month prospective evaluation
- Author
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Beatrice Ferrari Gozzi, Stefano Biagini, Lorenzo Mellini, Daniela Grieco, Ilaria Tarricone, Laura Mandelli, Beatrice Berti, Alessandro Serretti, Domenico Berardi, I. Tarricone, A. Serretti, B Ferrari Gozzi, L. Mandelli, D. Grieco, L. Mellini, S. Biagini, B. Berti, and D. Berardi.
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Psychosis ,Waist ,Adolescent ,medicine.drug_class ,medicine.medical_treatment ,Atypical antipsychotic ,Body Mass Index ,Internal medicine ,Medicine ,Humans ,Obesity ,Prospective Studies ,Antipsychotic ,Biological Psychiatry ,Aged ,Aged, 80 and over ,Metabolic Syndrome ,Chemotherapy ,business.industry ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Drug-naïve ,Endocrinology ,Schizophrenia ,Female ,business ,Body mass index ,medicine.drug - Abstract
The present study investigated the effects of second generation antipsychotics (SGA) on the metabolism of 15 antipsychotic-naïve outpatients. Evaluations were performed at baseline and after 1 month of treatment. A significant increase in mean body mass index (BMI) and mean waist circumference was observed. These results suggest the importance of monitoring patients from the first few weeks of antipsychotic treatment.
- Published
- 2006
13. The Grimani Breviary
- Author
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Giorgio E. Ferrari, Gian Lorenzo Mellini, Mario Salmi, and Jethro Hurt
- Subjects
Visual Arts and Performing Arts ,media_common.quotation_subject ,Art ,media_common - Published
- 1975
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