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Aging is the inevitable biological process that results in a progressive structural and functional decline associated with alterations in the resting/task-related brain activity, morphology, plasticity, and functionality. In the present study, we analyzed the effects of physiological aging on the human brain through entropy measures of electroencephalographic (EEG) signals. One hundred sixty-one participants were recruited and divided according to their age into young (n = 72) and elderly (n = 89) groups. Approximate entropy (ApEn) values were calculated in each participant for each EEG recording channel and both for the total EEG spectrum and for each of the main EEG frequency rhythms: delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-11 Hz), alpha 2 (11-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-45 Hz), to identify eventual statistical differences between young and elderly. To demonstrate that the ApEn represents the age-related brain changes, the computed ApEn values were used as features in an age-related classification of subjects (young vs elderly), through linear, quadratic, and cubic support vector machine (SVM). Topographic maps of the statistical results showed statistically significant difference between the ApEn values of the two groups found in the total spectrum and in delta, theta, beta 2, and gamma. The classifiers (linear, quadratic, and cubic SVMs) revealed high levels of accuracy (respectively 93.20 ± 0.37, 93.16 ± 0.30, 90.62 ± 0.62) and area under the curve (respectively 0.95, 0.94, 0.93). ApEn seems to be a powerful, very sensitive-specific measure for the study of cognitive decline and global cortical alteration/degeneration in the elderly EEG activity.

Objective. A large part of the cerebral cortex is dedicated to the processing of visual stimuli and there is still much to understand about such processing modalities and hierarchies. The main aim of the present study is to investigate the differences between directional visual stimuli (DS) and non-directional visual stimuli (n-DS) processing by time-frequency analysis of brain electroencephalographic activity during a visuo-motor task. Electroencephalography (EEG) data were divided into four regions of interest (ROIs) (frontal, central, parietal, occipital). Approach. The analysis of the visual stimuli processing was based on the combination of electroencephalographic recordings and time-frequency analysis. Event related spectral perturbations (ERSPs) were computed with spectrum analysis that allow to obtain the average time course of relative changes induced by the stimulus presentation in spontaneous EEG amplitude spectrum. Main results. Visual stimuli processing enhanced the same pattern of spectral modulation in all investigated ROIs with differences in amplitudes and timing. Additionally, statistically significant differences in occipital ROI between the DS and n-DS visual stimuli processing in theta, alpha and beta bands were found. Significance. These evidences suggest that ERSPs could be a useful tool to investigate the encoding of visual information in different brain regions. Because of their simplicity and their capability in the representation of brain activity, the ERSPs might be used as biomarkers of functional recovery for example in the rehabilitation of visual dysfunction and motor impairment following a stroke, as well as diagnostic tool of anomalies in brain functions in neurological diseases tailored to personalized treatments in clinical environment.