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4 results on '"Lorenzo Scatigno"'

1. Gut dysmotility in children with neurological impairment: the nutritional management

Author

Antonio Corsello, Lorenzo Scatigno, Annalisa Govoni, Gianvincenzo Zuccotti, Frédéric Gottrand, Claudio Romano, and Elvira Verduci

Subjects
gastrointestinal dysmotility, gut motility disorders, pediatric neurological impairment, neurometabolic diseases, nutritional management, enteral feeding, Neurology. Diseases of the nervous system, RC346-429
Abstract

Intestinal motility disorders represent a frequent problem in children with neurological impairment. These conditions are characterized by abnormal movements of the gut, which can result in symptoms such as constipation, diarrhea, reflux, and vomiting. The underlying mechanisms leading to dysmotility are various, and the clinical manifestations are often nonspecific. Nutritional management is an important aspect of care for children with gut dysmotility, as it can help to improve their quality of life. Oral feeding, when safe and in the absence of risk of ingestion or severe dysphagia, should always be encouraged. When oral nutrition is insufficient or potentially harmful, it is necessary to switch to an enteral by tube or parenteral nutrition before the onset of malnutrition. In most cases, children with severe gut dysmotility may require feeding via a permanent gastrostomy tube to ensure adequate nutrition and hydration. Drugs may be necessary to help manage gut dysmotility, such as laxatives, anticholinergics and prokinetic agents. Nutritional management of patients with neurological impairment often requires an individualized care plan to optimize growth and nutrition and to improve overall health outcomes. This review tries to sum up most significant neurogenetic and neurometabolic disorders associated with gut dysmotility that may require a specific multidisciplinary care, identifying a proposal of nutritional and medical management.

Published
2023
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2. Nutritional, Gastrointestinal and Endo-Metabolic Traps in the Management of Children with Spinal Muscular Atrophy Type 1

Author

Anna Mandelli, Dario Dilillo, Ruggiero Francavilla, Antonio Corsello, Valeria Calcaterra, V. Fabiano, Annalisa Govoni, Gloria Pelizzo, Elena Zoia, Sara Vizzuso, Alessandra Bosetti, Gian Vincenzo Zuccotti, Flavia Indrio, Lorenzo Scatigno, Elvira Verduci, and Martina Pascuzzi

Subjects
medicine.medical_specialty, Pediatrics, Neurological disability, pediatrics, business.industry, Spinal muscular atrophy, SMN1, medicine.disease, SMA, Dysphagia, Precocious pubarche, Parenteral nutrition, Medicine, medicine.symptom, business, Pediatric gastroenterology
Abstract

The management of patients with spinal muscular atrophy type 1 (SMA1) is constantly evolving. In just a few decades the medical approach has switched from an exclusively palliative therapy to a targeted therapy, transforming the natural history of the disease, improving survival time and quality of life, and creating new challenges and goals. Many nutritional problems, gastrointesti-nal disorders and metabolic and endocrine alterations are commonly identified in patients af-fected by SMA1 during childhood and adolescence. For this reason, a proper pediatric multidis-ciplinary approach is then required in the clinical care of these patients, with a specific focus on the prevention of most common complications. The purpose of this narrative review is to provide the clinician with a practical and usable tool about SMA1 patients care, through a comprehensive insight into the nutritional, gastroenterological, metabolic and endocrine management of SMA1. Considering the possible horizons opened thanks to new therapeutic frontiers, a nutritional and endo-metabolic surveillance is a crucial element to be considered for a proper clinical care of these patients.

Published
2021

3. Which Milk during the Second Year of Life: A Personalized Choice for a Healthy Future?

Author

Giulia Fiore, Elvira Verduci, Lorenzo Scatigno, Elisabetta Di Profio, Antonio Corsello, Alessandra Bosetti, and Gian Vincenzo Zuccotti

Subjects
Male, Vitamin, Pediatric Obesity, Anemia, Review, Childhood obesity, vitamin D deficiency, chemistry.chemical_compound, iron deficiency, nutrients intakes, Environmental health, Animals, Humans, Medicine, TX341-641, Micronutrients, Toddler, Infant Nutritional Physiological Phenomena, growing-up milk, Nutrition and Dietetics, Nutrition. Foods and food supply, business.industry, Nutritional Requirements, Infant, food and beverages, nutritional risks, second year of life, toddler, Iron deficiency, medicine.disease, Protein intake, anemia, protein intake, Infant Formula, Early life, vitamin d deficiency, Milk, chemistry, milk formula, Child, Preschool, Female, Diet, Healthy, Energy Intake, business, Nutritive Value, Food Science
Abstract

Nutrition in early life is a crucial element to provide all essential substrates for growth. Although this statement may appear obvious, several studies have shown how the intake of micro and macronutrients in toddlers differs a lot from the recommendations of scientific societies. Protein intake often exceeds the recommended amount, while the intake of iron and zinc is frequently insufficient, as well as Vitamin D. Nutritional errors in the first years of life can negatively impact the health of the child in the long term. To date, no clear evidence on which milk is suggested during the second year of life is yet to be established. In this study, we compare the nutrient profiles of cow’s milk and specific formulas as well as nutritional risks in toddlers linked to growth and childhood obesity development. The purpose of this review is to resume the latest clinical studies on toddlers fed with cow’s milk or young children formula (YCF), and the potential risks or benefits in the short and long term.

Published
2021
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4. Nutritional, Gastrointestinal and Endo-Metabolic Challenges in the Management of Children with Spinal Muscular Atrophy Type 1

Author

Ruggiero Francavilla, Antonio Corsello, Alessandra Bosetti, Dario Dilillo, Gloria Pelizzo, Lorenzo Scatigno, Flavia Indrio, V. Fabiano, Gian Vincenzo Zuccotti, Anna Mandelli, Sara Vizzuso, Annalisa Govoni, Elena Zoia, Valeria Calcaterra, Elvira Verduci, and Martina Chiara Pascuzzi

Subjects
0301 basic medicine, dysphagia, medicine.medical_treatment, spinal muscular atrophy type 1, Review, Disease, Spinal Muscular Atrophies of Childhood, 030105 genetics & heredity, Enteric Nervous System, Targeted therapy, 0302 clinical medicine, pediatric gastroenterology, TX341-641, SMA, Child, Nutrition and Dietetics, Combined Modality Therapy, Dysphagia, Natural history, Neuroprotective Agents, Treatment Outcome, Child, Preschool, medicine.symptom, Child Nutritional Physiological Phenomena, medicine.medical_specialty, Adolescent, neurological disability, Nutritional Status, 03 medical and health sciences, Quality of life (healthcare), nutritional management, medicine, Animals, Humans, enteral nutrition, endocrine disorders, Intensive care medicine, Pediatric gastroenterology, precocious pubarche, Nutrition. Foods and food supply, business.industry, Infant, Spinal muscular atrophy, medicine.disease, Gastrointestinal Tract, Parenteral nutrition, Gastrointestinal Absorption, Dietary Supplements, Energy Metabolism, business, SMN1, 030217 neurology & neurosurgery, Food Science
Abstract

The management of patients with spinal muscular atrophy type 1 (SMA1) is constantly evolving. In just a few decades, the medical approach has switched from an exclusively palliative therapy to a targeted therapy, transforming the natural history of the disease, improving survival time and quality of life and creating new challenges and goals. Many nutritional problems, gastrointestinal disorders and metabolic and endocrine alterations are commonly identified in patients affected by SMA1 during childhood and adolescence. For this reason, a proper pediatric multidisciplinary approach is then required in the clinical care of these patients, with a specific focus on the prevention of most common complications. The purpose of this narrative review is to provide the clinician with a practical and usable tool about SMA1 patients care, through a comprehensive insight into the nutritional, gastroenterological, metabolic and endocrine management of SMA1. Considering the possible horizons opened thanks to new therapeutic frontiers, a nutritional and endo-metabolic surveillance is a crucial element to be considered for a proper clinical care of these patients.

Published
2021
Full Text
View/download PDF

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