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20 results on '"Lorenzon, Giocondo"'

1. A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies

Author

Cirkel, Geert A., Kerklaan, Bojana Milojkovic, Vanhoutte, Frédéric, der Aa, Annegret Van, Lorenzon, Giocondo, Namour, Florence, Pujuguet, Philippe, Darquenne, Sophie, de Vos, Filip Y. F., Snijders, Tom J., Voest, Emile E., Schellens, Jan H. M., and Lolkema, Martijn P.

Published
2016
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8. Polarity and transport properties of rabbit kidney proximal tubule cells on collagen IV-coated porous membranes

Author

Genestie, Isabelle, Morin, Jean-Paul, Vannier, Bernard, and Lorenzon, Giocondo

Subjects
Renal tubular transport -- Research, Rabbits as laboratory animals -- Observations, Biological models -- Observations, Biological sciences
Abstract

An experiment was designed to study the bidirectional transport processes of kidney proximal tubule cells. Tight confluent polar monolayers of the rabbit kidney proximal tubule cells are formed on porous membranes coated with collagen IV after six days of culture and are maintained for about six days. These layers develop a gradient of L-lactate, ammonia, D-glucose and pH between the apical and basal parts of the medium. Transcellular transport of tetraethylammonia and unidirectional transport of p-aminohippurate occur from the basal to the apical components.

Published
1995

9. The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models

Author

Gravina, Giovanni, primary, Mancini, Andrea, additional, Colapietro, Alessandro, additional, Delle Monache, Simona, additional, Sferra, Roberta, additional, Vitale, Flora, additional, Cristiano, Loredana, additional, Martellucci, Stefano, additional, Marampon, Francesco, additional, Mattei, Vincenzo, additional, Beirinckx, Filip, additional, Pujuguet, Philippe, additional, Saniere, Laurent, additional, Lorenzon, Giocondo, additional, van der Aar, Ellen, additional, and Festuccia, Claudio, additional

Published
2019
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11. Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer12

Author

van der Horst, Geertje, van den Hoogen, Christel, Buijs, Jeroen T, Cheung, Henry, Bloys, Henny, Pelger, Rob CM, Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, and van der Pluijm, Gabri

Subjects
Male, Epithelial-Mesenchymal Transition, Mice, Nude, Osteoclasts, Antineoplastic Agents, Bone Neoplasms, Mice, Cell Line, Tumor, Tumor Microenvironment, Animals, Humans, Cell Proliferation, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Neovascularization, Pathologic, Reverse Transcriptase Polymerase Chain Reaction, Twist-Related Protein 1, Prostatic Neoplasms, Integrin alphaV, Immunohistochemistry, Xenograft Model Antitumor Assays, Tumor Burden, Gene Expression Regulation, Neoplastic, Animals, Newborn, Neoplastic Stem Cells, Research Article
Abstract

Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile, mesenchymal phenotype by epithelial-mesenchymal transition (EMT). Recently, it has been shown that EMT is functionally linked to prostate cancer stem cells, which are not only critically involved in prostate cancer maintenance but also in bone metastasis. We showed that treatment with the non-peptide α(v)-integrin antagonist GLPG0187 dose-dependently increased the E-cadherin/vimentin ratio, rendering the cells a more epithelial, sessile phenotype. In addition, GLPG0187 dose-dependently diminished the size of the aldehyde dehydrogenase high subpopulation of prostate cancer cells, suggesting that α(v)-integrin plays an important role in maintaining the prostate cancer stem/progenitor pool. Our data show that GLPG0187 is a potent inhibitor of osteoclastic bone resorption and angiogenesis in vitro and in vivo. Real-time bioluminescent imaging in preclinical models of prostate cancer demonstrated that blocking α(v)-integrins by GLPG0187 markedly reduced their metastatic tumor growth according to preventive and curative protocols. Bone tumor burden was significantly lower in the preventive protocol. In addition, the number of bone metastases/mouse was significantly inhibited. In the curative protocol, the progression of bone metastases and the formation of new bone metastases during the treatment period was significantly inhibited. In conclusion, we demonstrate that targeting of integrins by GLPG0187 can inhibit the de novo formation and progression of bone metastases in prostate cancer by antitumor (including inhibition of EMT and the size of the prostate cancer stem cell population), antiresorptive, and antiangiogenic mechanisms.

Published
2011

12. Targeting of Alpha-V Integrins Reduces Malignancy of Bladder Carcinoma

Author

van der Horst, Geertje, primary, Bos, Lieke, additional, van der Mark, Maaike, additional, Cheung, Henry, additional, Heckmann, Bertrand, additional, Clément-Lacroix, Philippe, additional, Lorenzon, Giocondo, additional, Pelger, Rob C. M., additional, Bevers, Rob F. M., additional, and van der Pluijm, Gabri, additional

Published
2014
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13. Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer

Author

van der Horst, Geertje, primary, van den Hoogen, Christel, additional, Buijs, Jeroen T., additional, Cheung, Henry, additional, Bloys, Henny, additional, Pelger, Rob C.M., additional, Lorenzon, Giocondo, additional, Heckmann, Bertrand, additional, Feyen, Jean, additional, Pujuguet, Philippe, additional, Blanque, Roland, additional, Clément-Lacroix, Philippe, additional, and van der Pluijm, Gabri, additional

Published
2011
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15. A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco–toxicology

Author

de Sousa, Georges, primary, Nicolas, Florence, additional, Placidi, Michel, additional, Rahmani, Roger, additional, Benicourt, Marc, additional, Vannier, Bernard, additional, Lorenzon, Giocondo, additional, Mertens, Karine, additional, Coecke, Sandra, additional, Callaerts, Andre, additional, Rogiers, Vera, additional, Khan, Shamas, additional, Roberts, Phil, additional, Skett, Paul, additional, Fautrel, Alain, additional, Chesne, Christophe, additional, and Guillouzo, Andre, additional

Published
1999
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17. The Practical Applicability of Hepatocyte Cultures in Routine Testing

Author

Blaauboer, Bas J., primary, Boobis, Alan R., additional, Castell, Jose V., additional, Coecke, Sandra, additional, Groothuis, Geny M.M., additional, Guillouzo, Andre, additional, Hall, Tony J., additional, Hawksworth, Gabrielle M., additional, Lorenzon, Giocondo, additional, Miltenburger, Herbert G., additional, Rogiers, Vera, additional, Skett, Paul, additional, Villa, Pia, additional, and Wiebel, Friedrich J., additional

Published
1994
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18. A Multicentre Study of AcuteIn VitroCytotoxicity in Rat Hepatocytes: Tentative Correlation BetweenIn VitroToxicities andIn VivoData

Author

Fautrel, Alain, primary, Chesné, Christophe, additional, Guillouzo, André, additional, Sousa, Georges De, additional, Placidi, Michel, additional, Rahmani, Roger, additional, Braut, Françoise, additional, Pichon, Jacqueline, additional, Hoellinger, Henri, additional, Vintèzou, Pascale, additional, Melcion, Celine, additional, Cordier, André, additional, Lorenzon, Giocondo, additional, Benicourt, Marc, additional, Fournex, Robert, additional, Bichet, Nicole, additional, and Gouy, Daniel, additional

Published
1993
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20. Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer.

Author

van der Horst, Geertje, Van den Hoogen, Christel, Buijs, Jeroen T., Cheung, Henry, Bloys, Henny, Pelger, Rob C. M., Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, and van der Pluijm, Gabri

Subjects
*INTEGRINS, *BONE metastasis, *PROSTATE cancer, *PHENOTYPES, *EPITHELIAL cells, *BONE tumors, TUMOR growth prevention
Abstract

Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile, mesenchymal phenotype by epithelial-mesenchymal transition (EMT). Recently, it has been shown that EMT is functionally linked to prostate cancer stem cells, which are not only critically involved in prostate cancer maintenance but also in bone metastasis. We showed that treatment with the non-peptide αv-integrin antagonist GLPG0187 dose-dependently increased the E-cadherin/vimentin ratio, rendering the cells a more epithelial, sessile phenotype. In addition, GLPG0187 dose-dependently diminished the size of the aldehyde dehydrogenase high subpopulation of prostate cancer cells, suggesting that αv-integrin plays an important role in maintaining the prostate cancer stem/progenitor pool. Our data show that GLPG0187 is a potent inhibitor of osteoclastic bone resorption and angiogenesis in vitro and in vivo. Real-time bioluminescent imaging in preclinical models of prostate cancer demonstrated that blocking αv-integrins by GLPG0187 markedly reduced their metastatic tumor growth according to preventive and curative protocols. Bone tumor burden was significantly lower in the preventive protocol. In addition, the number of bone metastases/mouse was significantly inhibited. In the curative protocol, the progression of bone metastases and the formation of new bone metastases during the treatment period was significantly inhibited. In conclusion, we demonstrate that targeting of integrins by GLPG0187 can inhibit the de novo formation and progression of bone metastases in prostate cancer by anti-tumor (including inhibition of EMT and the size of the prostate cancer stem cell population), antiresorptive, and antiangiogenic mechanisms. [ABSTRACT FROM AUTHOR]

Published
2011
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