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Your search keyword '"Losappio, Vincenzo"' showing total 11 results
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11 results on '"Losappio, Vincenzo"'

2. mTOR and SGLT-2 Inhibitors: Their Synergistic Effect on Age-Related Processes.

Author

Troise, Dario, Mercuri, Silvia, Infante, Barbara, Losappio, Vincenzo, Cirolla, Luciana, Netti, Giuseppe Stefano, Ranieri, Elena, and Stallone, Giovanni

Subjects
MTOR inhibitors, CELL growth, DRUG development, MEDICAL care costs, AGING
Abstract

The aging process contributes significantly to the onset of chronic diseases, which are the primary causes of global mortality, morbidity, and healthcare costs. Numerous studies have shown that the removal of senescent cells from tissues extends lifespan and reduces the occurrence of age-related diseases. Consequently, there is growing momentum in the development of drugs targeting these cells. Among them, mTOR and SGLT-2 inhibitors have garnered attention due to their diverse effects: mTOR inhibitors regulate cellular growth, metabolism, and immune responses, while SGLT-2 inhibitors regulate glucose reabsorption in the kidneys, resulting in various beneficial metabolic effects. Importantly, these drugs may act synergistically by influencing senescence processes and pathways. Although direct studies on the combined effects of mTOR inhibition and SGLT-2 inhibition on age-related processes are limited, this review aims to highlight the potential synergistic benefits of these drugs in targeting senescence. [ABSTRACT FROM AUTHOR]

Published
2024
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9. A Single-Center Cohort Study to Define the Role of Pretransplant Biopsy Score in the Long-term Outcome of Kidney Transplantation

Author

Losappio, Vincenzo, primary, Stallone, Giovanni, additional, Infante, Barbara, additional, Schena, Antonio, additional, Rossini, Michele, additional, Maiorano, Annamaria, additional, Fiorentino, Marco, additional, Ditonno, Pasquale, additional, Lucarelli, Giuseppe, additional, Battaglia, Michele, additional, Gesualdo, Loreto, additional, and Grandaliano, Giuseppe, additional

Published
2014
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