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1. Clinical characteristics and molecular aspects of low-grade serous ovarian and peritoneal cancer: a multicenter, observational, retrospective analysis of MITO Group (MITO 22)

Author

Musacchio, Lucia, Califano, Daniela, Bartoletti, Michele, Arenare, Laura, Lorusso, Domenica, Losito, Nunzia Simona, Cormio, Gennaro, Greggi, Stefano, Raspagliesi, Francesco, Valabrega, Giorgio, Salutari, Vanda, Pisano, Carmela, Spina, Anna, Russo, Daniela, Del Sesto, Michele, Canzonieri, Vincenzo, Ferraù, Francesco, Zannoni, Gian Franco, Loizzi, Vera, Ghizzoni, Viola, Casanova, Claudia, Tuninetti, Valentina, Ducceschi, Monika, Del Vecchio, Vittoria, Scalone, Simona, Priolo, Domenico, Perrone, Francesco, Scambia, Giovanni, and Pignata, Sandro

Published
2022
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6. Combined Papillary and Mucoepidermoid Carcinoma of the Thyroid Gland: a Possible Collision Tumor Diagnosed on Fine-Needle Cytology. Report of a Case with Immunocytochemical and Molecular Correlations

Author

Fulciniti, Franco, Vuttariello, Emilia, Calise, Celeste, Monaco, Mario, Pezzullo, Luciano, Chiofalo, Maria Grazia, Di Gennaro, Francesca, Malzone, Maria Gabriella, Campanile, Anna Cipolletta, Losito, Nunzia Simona, Botti, Gerardo, and Chiappetta, Gennaro

Published
2015
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7. Analysis of A Disintegrin and Metalloprotease 17 (ADAM17) Expression as a Prognostic Marker in Ovarian Cancer Patients Undergoing First-Line Treatment Plus Bevacizumab

Author

Fabbi, Marina, primary, Costa, Delfina, additional, Russo, Daniela, additional, Arenare, Laura, additional, Gaggero, Gabriele, additional, Signoriello, Simona, additional, Scambia, Giovanni, additional, Pisano, Carmela, additional, Colombo, Nicoletta, additional, Losito, Nunzia Simona, additional, Filaci, Gilberto, additional, Spina, Anna, additional, Califano, Daniela, additional, Scognamiglio, Giosuè, additional, Gadducci, Angiolo, additional, Mezzanzanica, Delia, additional, Bagnoli, Marina, additional, Ferrini, Silvano, additional, Canzonieri, Vincenzo, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, and Pignata, Sandro, additional

Published
2022
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8. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients

Author

D’Alterio, Crescenzo, primary, Spina, Anna, additional, Arenare, Laura, additional, Chiodini, Paolo, additional, Napolitano, Maria, additional, Galdiero, Francesca, additional, Portella, Luigi, additional, Simeon, Vittorio, additional, Signoriello, Simona, additional, Raspagliesi, Francesco, additional, Lorusso, Domenica, additional, Pisano, Carmela, additional, Colombo, Nicoletta, additional, Zannoni, Gian Franco, additional, Losito, Nunzia Simona, additional, De Cecio, Rossella, additional, Scognamiglio, Giosuè, additional, Califano, Daniela, additional, Russo, Daniela, additional, Tuninetti, Valentina, additional, Piccirillo, Maria Carmela, additional, Gargiulo, Piera, additional, Perrone, Francesco, additional, Pignata, Sandro, additional, and Scala, Stefania, additional

Published
2022
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10. TLR4 Expression in Ex-Lichenoid Lesions—Oral Squamous Cell Carcinomas and Its Surrounding Epithelium: The Role of Tumor Inflammatory Microenvironment

Author

Visioli, Fernanda, primary, Nunes, Julia Silveira, additional, Pedicillo, Maria Carmela, additional, Leonardi, Rosalia, additional, Santoro, Angela, additional, Zannoni, Gian Franco, additional, Aquino, Gabriella, additional, Cerrone, Margherita, additional, Cantile, Monica, additional, Losito, Nunzia Simona, additional, Rodolico, Vito, additional, Campisi, Giuseppina, additional, Colella, Giuseppe, additional, De Stefano, Ilenia Sara, additional, Ramunno, Maria Antonietta, additional, Pizzulli, Cristina, additional, Visconti, Marco, additional, Lo Muzio, Lorenzo, additional, and Pannone, Giuseppe, additional

Published
2022
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11. AKT Isoforms Interplay in High-Grade Serous Ovarian Cancer Prognosis and Characterization

Author

Azzalini, Eros, primary, Tierno, Domenico, additional, Bartoletti, Michele, additional, Barbazza, Renzo, additional, Giorda, Giorgio, additional, Puglisi, Fabio, additional, Cecere, Sabrina Chiara, additional, Losito, Nunzia Simona, additional, Russo, Daniela, additional, Stanta, Giorgio, additional, Canzonieri, Vincenzo, additional, and Bonin, Serena, additional

Published
2022
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12. Brooke-Spiegler syndrome presenting multiple concurrent cutaneous and parotid gland neoplasms: Cytologic findings on fine-needle sample and description of a novel mutation of the CYLD gene

Author

Malzone, Maria Gabriella, Campanile, Anna Cipolletta, Losito, Nunzia Simona, Longo, Francesco, Perri, Francesco, Caponigro, Francesco, Schiavone, Concetta, Ionna, Franco, Maiello, Francesco, Martinuzzi, Claudia, Nasti, Sabina, Botti, Gerardo, and Fulciniti, Franco

Published
2015
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13. Evaluation of Angiogenesis-Related Genes as Prognostic Biomarkers of Bevacizumab Treated Ovarian Cancer Patients: Results from the Phase IV MITO16A/ManGO OV-2 Translational Study

Author

Califano, Daniela, primary, Gallo, Daniela, additional, Rampioni Vinciguerra, Gian Luca, additional, De Cecio, Rossella, additional, Arenare, Laura, additional, Signoriello, Simona, additional, Russo, Daniela, additional, Ferrandina, Gabriella, additional, Citron, Francesca, additional, Losito, Nunzia Simona, additional, Gargiulo, Piera, additional, Simeon, Vittorio, additional, Scambia, Giovanni, additional, Cecere, Sabrina Chiara, additional, Montella, Marco, additional, Colombo, Nicoletta, additional, Tognon, Germana, additional, Bignotti, Eliana, additional, Zannoni, Gian Franco, additional, Canzonieri, Vincenzo, additional, Ciucci, Alessandra, additional, Spina, Anna, additional, Scognamiglio, Giosuè, additional, Del Sesto, Michele, additional, Schettino, Clorinda, additional, Piccirillo, Maria Carmela, additional, Perrone, Francesco, additional, Chiodini, Paolo, additional, Pignata, Sandro, additional, and Baldassarre, Gustavo, additional

Published
2021
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16. Malignant Sinonasal Tumors: Update on Histological and Clinical Management

Author

Bracigliano, Alessandra, primary, Tatangelo, Fabiana, additional, Perri, Francesco, additional, Di Lorenzo, Giuseppe, additional, Tafuto, Roberto, additional, Ottaiano, Alessandro, additional, Clemente, Ottavia, additional, Barretta, Maria Luisa, additional, Losito, Nunzia Simona, additional, Santorsola, Mariachiara, additional, and Tafuto, Salvatore, additional

Published
2021
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18. Arthralgia in patients with ovarian cancer treated with bevacizumab and chemotherapy

Author

Ventriglia, Jole, primary, Paciolla, Immacolata, additional, Pisano, Carmela, additional, Tambaro, Rosa, additional, Cecere, Sabrina Chiara, additional, Di Napoli, Marilena, additional, Attademo, Laura, additional, Arenare, Laura, additional, Spina, Anna, additional, Russo, Daniela, additional, Califano, Daniela, additional, Losito, Nunzia Simona, additional, Setola, Sergio Venanzio, additional, Franzese, Elisena, additional, De Vita, Ferdinando, additional, Orditura, Michele, additional, and Pignata, Sandro, additional

Published
2020
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19. Ovarian Cancer Translational Activity of the Multicenter Italian Trial in Ovarian Cancer (MITO) Group: Lessons Learned in 10 Years of Experience

Author

Califano, Daniela, primary, Russo, Daniela, additional, Scognamiglio, Giosuè, additional, Losito, Nunzia Simona, additional, Spina, Anna, additional, Bello, Anna Maria, additional, Capiluongo, Anna, additional, Galdiero, Francesca, additional, De Cecio, Rossella, additional, Bevilacqua, Simona, additional, Gargiulo, Piera, additional, Marchesi, Edoardo, additional, Canevari, Silvana, additional, Perrone, Francesco, additional, Daniele, Gennaro, additional, De Cecco, Loris, additional, Mezzanzanica, Delia, additional, and Pignata, Sandro, additional

Published
2020
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23. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients.

Author

D'Alterio, Crescenzo, Spina, Anna, Arenare, Laura, Chiodini, Paolo, Napolitano, Maria, Galdiero, Francesca, Portella, Luigi, Simeon, Vittorio, Signoriello, Simona, Raspagliesi, Francesco, Lorusso, Domenica, Pisano, Carmela, Colombo, Nicoletta, Zannoni, Gian Franco, Losito, Nunzia Simona, De Cecio, Rossella, Scognamiglio, Giosuè, Califano, Daniela, Russo, Daniela, and Tuninetti, Valentina

Subjects
OVARIAN tumors, STROMAL cells, CANCER patients, TUMOR markers
Abstract

Simple Summary: Despite rapid progress in the research on epithelial ovarian cancer (EOC), it is usually diagnosed during the advanced stage with only 30% of patients surviving longer than 5 years. This is the first study in which the whole CXCR4-CXCL12-CXCR7 axis was systematically evaluated in tumor and stromal cells, through rigorous statistical methods in a prospective clinical trial. CXCL12 expression in cancer cells is associated with worse progression-free survival in stage III EOC patients, and deserves further attention as a potential prognostic and therapeutic target. This study investigated the prognostic role of the CXCR4-CXCL12-CXCR7 axis in advanced epithelial ovarian cancer (EOC) patients receiving first-line treatment within the MITO16A/MaNGO-OV2 phase-IV trial. CXCR4-CXCL12-CXCR7 expression was evaluated in the epithelial and stromal component of 308 EOC IHC-stained tumor samples. The statistical analysis focused on biomarkers' expression, their association with other variables and prognostic value. Zero-inflated tests, shrinkage, bootstrap procedures, and multivariable models were applied. The majority of EOC (75.0%) expressed CXCR4 and CXCR7, 56.5% expressed the entire CXCR4-CXCL12-CXCR7 axis, while only 4.6% were negative for CXCL12 and its cognate receptors, in regard to the epithelial component. Stromal CXCL12 and CXCR7, expressed in 11.2% and 65.5%, respectively, were associated with the FIGO stage. High CXCL12 in epithelial cancer cells was associated with shorter progression-free and overall survival. However, after adjusting for overfitting due to best cut-off multiplicity testing, the significance was lost. This is a wide-ranging, prospective study in which CXCR4-CXCL12-CXCR7 were systematically evaluated in epithelial and stromal components, in selected stage III-IV EOC. Although CXCL12 was not prognostic, epithelial expression identified high-risk FIGO stage III patients for PFS. These data suggest that it might be worth studying the CXCL12 axis as a therapeutic target to improve treatment efficacy in EOC patients. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Massive edema of ovary with cytogenetic alteration of chromosome 12q13-15 in adolescent patient: a case report

Author

De Cecio Rossella, Cantile Monica, Fortunato Nicola, De Chiara Annarosaria, Losito Nunzia Simona, Franco Renato, and Botti Gerardo

Subjects
Ovarian edema, Sarcoma-like, CHOP translocation, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background The massive edema of ovary, with or without fibromatosis, is a rare tumor-like entity characterized by an increase in volume of one or both ovaries for accumulation of edema fluid in the stroma that separates the follicular structures. Case We report a rare case, very peculiar also for its association with a massive stromal fibromatosis and for the presence, never described, of tumoral areas with CHOP gene translocation, on chromosome 12q13–15.

Published
2013
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25. Pleomorphic adenoma of salivary gland and synchronous/metachronous invasive ductal breast cancer: a casual coincidence or a clinical presentation resulting from common genetic events?

Author

Longo, Francesco, Sabatino, Rocco, Aquino, Gabriella, Losito, Nunzia Simona, Cantile, Monica, Ionna, Franco, and Botti, Gerardo

Subjects
Original Article
Abstract

Breast and salivary glands have similar morphological and pathological features; however genetic relation between these lesions were not described. In this report we described a small series of biomarkers that developed synchronously or metachronous pleomorphic adenoma of the salivary glands and invasive breast cancer, on which we have tested, by immunohistochemistry, several of bio-markers that may be associated with the pathogenesis of both malignancies. In conclusion, we suggest to better investigate early genetic alterations that could underlie of the synchronous occurrence of these lesions.

Published
2018

26. Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma

Author

Troiano, Giuseppe, primary, Caponio, Vito Carlo Alberto, additional, Botti, Gerardo, additional, Aquino, Gabriella, additional, Losito, Nunzia Simona, additional, Pedicillo, Maria Carmela, additional, Zhurakivska, Khrystyna, additional, Arena, Claudia, additional, Ciavarella, Domenico, additional, Mastrangelo, Filiberto, additional, Lo Russo, Lucio, additional, Lo Muzio, Lorenzo, additional, and Pannone, Giuseppe, additional

Published
2019
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27. AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer

Author

Collina, Francesca, primary, La Sala, Lucia, additional, Liotti, Federica, additional, Prevete, Nella, additional, La Mantia, Elvira, additional, Chiofalo, Maria Grazia, additional, Aquino, Gabriella, additional, Arenare, Laura, additional, Cantile, Monica, additional, Liguori, Giuseppina, additional, Di Gennaro, Francesca, additional, Pezzullo, Luciano, additional, Losito, Nunzia Simona, additional, Vecchio, Giancarlo, additional, Botti, Gerardo, additional, Melillo, Rosa Marina, additional, and Franco, Renato, additional

Published
2019
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28. Overexpression of ADAR 1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma

Author

Caponio, Vito Carlo Alberto, primary, Troiano, Giuseppe, additional, Botti, Gerardo, additional, Pedicillo, Maria Carmela, additional, Lo Russo, Lucio, additional, Mastrangelo, Filiberto, additional, Ciavarella, Domenico, additional, Losito, Nunzia Simona, additional, Aquino, Gabriella, additional, Nocini, Riccardo, additional, Santoro, Rossella, additional, Santoro, Angela, additional, Lo Muzio, Lorenzo, additional, and Pannone, Giuseppe, additional

Published
2018
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29. Large deletion at the CDC73 gene locus and search for predictive markers of the presence of a CDC73 genetic lesion

Author

Muscarella, Lucia Anna, primary, Turchetti, Daniela, additional, Fontana, Andrea, additional, Baorda, Filomena, additional, Palumbo, Orazio, additional, la Torre, Annamaria, additional, de Martino, Danilo, additional, Franco, Renato, additional, Losito, Nunzia Simona, additional, Repaci, Andrea, additional, Pagotto, Uberto, additional, Cinque, Luigia, additional, Copetti, Massimiliano, additional, Chiofalo, Maria Grazia, additional, Pezzullo, Luciano, additional, Graziano, Paolo, additional, Scillitani, Alfredo, additional, and Guarnieri, Vito, additional

Published
2018
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30. Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial

Author

Caponigro, Francesco, primary, Di Gennaro, Elena, additional, Ionna, Franco, additional, Longo, Francesco, additional, Aversa, Corrado, additional, Pavone, Ettore, additional, Maglione, Maria Grazia, additional, Di Marzo, Massimiliano, additional, Muto, Paolo, additional, Cavalcanti, Ernesta, additional, Petrillo, Antonella, additional, Sandomenico, Fabio, additional, Maiolino, Piera, additional, D’Aniello, Roberta, additional, Botti, Gerardo, additional, De Cecio, Rossella, additional, Losito, Nunzia Simona, additional, Scala, Stefania, additional, Trotta, Annamaria, additional, Zotti, Andrea Ilaria, additional, Bruzzese, Francesca, additional, Daponte, Antonio, additional, Calogero, Ester, additional, Montano, Massimo, additional, Pontone, Monica, additional, De Feo, Gianfranco, additional, Perri, Francesco, additional, and Budillon, Alfredo, additional

Published
2016
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31. Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma.

Author

Caponio, Vito Carlo Alberto, Troiano, Giuseppe, Botti, Gerardo, Pedicillo, Maria Carmela, Lo Russo, Lucio, Mastrangelo, Filiberto, Ciavarella, Domenico, Losito, Nunzia Simona, Aquino, Gabriella, Nocini, Riccardo, Santoro, Rossella, Santoro, Angela, Lo Muzio, Lorenzo, and Pannone, Giuseppe

Subjects
GENETIC overexpression, CYTOPLASM, SQUAMOUS cell carcinoma, ORAL cancer patients, CANCER prognosis, RNA editing, IMMUNOHISTOCHEMISTRY, GENE expression, PROTEIN metabolism, RNA metabolism, GENETIC techniques, HYDROLASES, MOUTH tumors, PROGNOSIS, PROTEINS, QUESTIONNAIRES, RNA, PROTEIN microarrays
Abstract

Background: ADAR1 is an enzymatic protein, which catalyzes a RNA editing reaction by converting Adenosine to Inosine, and its expression has been found to be dysregulated in many cancer types. The aim of this study was to analyze the expression of ADAR1 in oral squamous cells carcinoma.Methods: In order to analyze the ADAR1 mRNA expression, data from The Cancer Genome Atlas (TCGA) database were downloaded and analyzed. In addition, immunohistochemistry analysis was performed on an institutional database including 46 samples of oral squamous cell carcinoma in a tissue microarray (TMA).Results: No statistically significant correlation linked the mRNA ADAR1 expression to any clinic-pathological variables in the TCGA database. Immunohistochemistry analysis of ADAR1 showed different expressions between normal mucosa and tumor tissue. Focusing on the subcellular localization, the nuclear expression of ADAR1 correlated with higher grading of differentiation (ρ = 0.442; P-value = 0.002); the general expression of ADAR1 either in cytoplasm or in nuclei, correlated with the Gender of patients (Cytoplasm expression: ρ = -0.295; P-value = 0.049; while for nuclear expression: ρ = +0.374; P = 0.011); cytosol expression resulted to be an independent protective prognostic factor (HR = 0.047; C.I. 95% 0.007-0.321; P-value = 0.002).Conclusion: Higher expression of ADAR1 into the cytoplasm resulted to be an independent prognostic factor. In order to understand ADAR1 role in cancer, further studies should be performed, in bigger cohort and under a bio-molecular point of view. [ABSTRACT FROM AUTHOR]

Published
2019
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32. CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR

Author

Circelli, Luisa, primary, Sciammarella, Concetta, additional, Guadagno, Elia, additional, Tafuto, Salvatore, additional, del Basso de Caro, Marialaura, additional, Botti, Giovanni, additional, Pezzullo, Luciano, additional, Aria, Massimo, additional, Ramundo, Valeria, additional, Tatangelo, Fabiana, additional, Losito, Nunzia Simona, additional, Ieranò, Caterina, additional, D’Alterio, Crescenzo, additional, Izzo, Francesco, additional, Ciliberto, Gennaro, additional, Colao, Annamaria, additional, Faggiano, Antongiulio, additional, and Scala, Stefania, additional

Published
2016
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33. Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role.

Author

Aquino, Gabriella, Collina, Francesca, Sabatino, Rocco, Cerrone, Margherita, Longo, Francesco, Ionna, Franco, Losito, Nunzia Simona, De Cecio, Rossella, Cantile, Monica, Pannone, Giuseppe, and Botti, Gerardo

Subjects
SEX hormone receptors, SALIVARY gland tumors, ESTROGEN receptors, PROGESTERONE receptors, ANDROGEN receptors, ADENOID cystic carcinoma
Abstract

The role of sex hormone receptors in human cancer development and progression has been well documented in numerous studies, as has the success of sex hormone antagonists in the biological therapy of many human tumors. In salivary gland tumors (SGTs), little and conflicting information about the role of the estrogen receptor alpha (ERα), progesterone receptor (PgR) and androgen receptor (AR) has been described and in most cases the use of sex hormone antagonists is not contemplated in clinical practice. In this study, we analyzed a panel of sex hormone receptors that have not been widely investigated in SGTs—ERα, PgR, AR, but also ERβ and GPR30—to define their expression pattern and their prognostic and predictive value in a case series of 69 benign and malignant SGTs. We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients. [ABSTRACT FROM AUTHOR]

Published
2018
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35. Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer

Author

Galdiero, Francesca, primary, Romano, Annunciata, additional, Pasquinelli, Rosa, additional, Pignata, Sandro, additional, Greggi, Stefano, additional, Vuttariello, Emilia, additional, Bello, Anna Maria, additional, Calise, Celeste, additional, Scaffa, Cono, additional, Pisano, Carmela, additional, Losito, Nunzia Simona, additional, Fusco, Alfredo, additional, Califano, Daniela, additional, and Chiappetta, Gennaro, additional

Published
2015
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36. Follicular thyroid carcinoma with skull metastases

Author

Chiofalo, Maria Grazia, primary, Setola, Sergio Venanzio, additional, Gennaro, Francesca Di, additional, Fulciniti, Franco, additional, Catapano, Giuseppe, additional, Losito, Nunzia Simona, additional, Sandomenico, Fabio, additional, Catalano, Orlando, additional, and Pezzullo, Luciano, additional

Published
2015
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39. High HMGA2 expression and high body mass index negatively affect the prognosis of patients with ovarian cancer

Author

Califano, Daniela, primary, Pignata, Sandro, additional, Losito, Nunzia Simona, additional, Ottaiano, Alessandro, additional, Greggi, Stefano, additional, De Simone, Veronica, additional, Cecere, Sabrina, additional, Aiello, Concetta, additional, Esposito, Francesco, additional, Fusco, Alfredo, additional, and Chiappetta, Gennaro, additional

Published
2013
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40. Lung cancer diagnosis on ovary mass: a case report

Author

Losito, Nunzia Simona, primary, Scaffa, Cono, additional, Cantile, Monica, additional, Botti, Gerardo, additional, Costanzo, Raffaele, additional, Manna, Angela, additional, Franco, Renato, additional, and Greggi, Stefano, additional

Published
2013
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41. Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types.

Author

Scognamiglio, Giosuè, De Chiara, Anna, Di Bonito, Maurizio, Fabiana Tatangelo, Losito, Nunzia Simona, Anniciello, Annamaria, De Cecio, Rossella, D'Alterio, Crescenzo, Scala, Stefania, Cantile, Monica, and Botti, Gerardo

Subjects
IMMUNOSTAINING, CELL physiology, IMMUNOMODULATORS, IMMUNOGLOBULINS, CANCER cells
Abstract

In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate with a poor prognosis of patients with several types of cancer. However, recent reports have revealed that the immunohistochemical (IHC) expression of the PD-L1 in tumor cells is not uniform for the use of different antibodies clones, with variable specificity, often doubtful topographical localization, and with a score not uniquely defined. The purpose of this study was to analyze the IHC expression of PD-L1 on a large series of several human tumors to correctly define its staining in different tumor tissues. [ABSTRACT FROM AUTHOR]

Published
2016
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42. Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen

Author

Aquino, Gabriella, primary, Sabatino, Rocco, additional, Cantile, Monica, additional, Aversa, Corrado, additional, Ionna, Franco, additional, Botti, Gerardo, additional, La Mantia, Elvira, additional, Collina, Francesca, additional, Malzone, Gabriella, additional, Pannone, Giuseppe, additional, Losito, Nunzia Simona, additional, Franco, Renato, additional, and Longo, Francesco, additional

Published
2013
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43. Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

Author

Chiofalo, Maria Grazia, primary, Losito, Nunzia Simona, additional, Fulciniti, Franco, additional, Setola, Sergio Venanzio, additional, Tommaselli, Antonio, additional, Marone, Ugo, additional, Di Cecilia, Maria Luisa, additional, and Pezzullo, Luciano, additional

Published
2012
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46. FEZ1/LZTS1 protein expression in ovarian cancer

Author

Califano, Daniela, primary, Pignata, Sandro, additional, Pisano, Carmela, additional, Greggi, Stefano, additional, Laurelli, Giuseppe, additional, Losito, Nunzia Simona, additional, Ottaiano, Alessandro, additional, Gallipoli, Adolfo, additional, Pasquinelli, Rosa, additional, De Simone, Veronica, additional, Cirombella, Roberto, additional, Fusco, Alfredo, additional, and Chiappetta, Gennaro, additional

Published
2009
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48. High HMGA2 Expression and High Body Mass Index Negatively Affect the Prognosis of Patients With Ovarian Cancer.

Author

Califano, Daniela, Pignata, Sandro, Losito, Nunzia Simona, Ottaiano, Alessandro, Greggi, Stefano, De Simone, Veronica, Cecere, Sabrina, Aiello, Concetta, Esposito, Francesco, Fusco, Alfredo, and Chiappetta, Gennaro

Subjects
GENE expression, BODY mass index, OVARIAN cancer, CHROMATIN, ADIPOGENESIS, IMMUNOHISTOCHEMISTRY, PROGNOSIS
Abstract

HMGA2 is a small, non-histone, chromatin-associated protein with a key role in tumorigenesis and adipogenesis. Indeed, HMGA2 overexpression has been frequently detected in several malignant neoplasms and inhibition of its expression prevents thyroid cell transformation. Moreover, HMGA2 null mice show a pigmy phenotype with a great reduction in fat tissue. To investigate whether HMGA2 expression correlates with clinico-pathological parameters and patient outcome, immunohistochemical analysis of HMGA2 expression was performed in ovarian cancer specimens from 117 patients. HMGA2 overexpression was found in 39% of the cases and, interestingly, positively correlated with the body mass index (BMI). Moreover, high BMI (≥25 kg/m2) and high HMGA2 expression/BMI combined evaluation predicted shorter disease-free survival. High BMI (≥25 kg/m2), high expression of HMGA2 and high HMGA2 expression/BMI combined evaluation predicted shorter overall survival. In multivariate analysis, the concomitant high expression of HMGA2 and high BMI (≥25 kg/m2) was an independent prognostic factor. Finally, the BMI (≥25 kg/m2) negatively correlated with the patient response to chemotherapy ( P = 0.039). Therefore, the data reported herein suggest that the combined evaluation of HMGA2 expression and obesity assessed through BMI can be considered a marker of poor prognosis in patients affected by ovarian carcinoma. J. Cell. Physiol. 229: 53-59, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2014
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49. FEZ1/LZTS1 protein expression in ovarian cancer.

Author

CALIFANO, DANIELA, PIGNATA, SANDRO, PISANO, CARMELA, GREGGI, STEFANO, LAURELLI, GIUSEPPE, LOSITO, NUNZIA SIMONA, OTTAIANO, ALESSANDRO, GALLIPOLI, ADOLFO, PASQUINELLI, ROSA, DE SIMONE, VERONICA, CIROMBELLA, ROBERTO, FUSCO, ALFREDO, and CHIAPPETTA, GENNARO

Subjects
GENE expression, CHROMOSOMES, OVARIAN cancer, PROTEINS, DRUG therapy, CANCER patients
Abstract

The FEZ1/LZTS1 (FEZ1) gene maps to chromosome 8p22 and is frequently altered in human cancer. FEZ1 has been proposed as a candidate tumour suppressor gene and its loss may contribute to tumour progression. We have analysed the expression of FEZ1 protein in tissues from ovarian carcinomas in relation to clinico-pathological variables, response to chemotherapy and disease-free and overall survival. FEZ1 status was assessed by immunohistochemistry. Cytoplasmic staining for FEZ1 protein was absent or drastically reduced in 38% of tumours. FEZ1 protein expression was not related to tumour grade, histotype, disease-free survival, or overall survival. On the contrary, it was significantly correlated with age and with FIGO stage of disease. This finding indicates that FEZ1 is involved in ovarian carcinogenesis. Moreover, loss of FEZ1 protein significantly predicted a complete treatment response in patients who received taxane-based chemotherapy. In conclusion, the reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma. J. Cell. Physiol. 222: 382–386, 2010. © 2009 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma.

Author

Troiano, Giuseppe, Caponio, Vito Carlo Alberto, Botti, Gerardo, Aquino, Gabriella, Losito, Nunzia Simona, Pedicillo, Maria Carmela, Zhurakivska, Khrystyna, Arena, Claudia, Ciavarella, Domenico, Mastrangelo, Filiberto, Lo Russo, Lucio, Lo Muzio, Lorenzo, and Pannone, Giuseppe

Subjects
CYCLINS, SQUAMOUS cell carcinoma, PROGRESSION-free survival, ORAL mucosa, STATISTICAL correlation, RNA-binding proteins, DOWNLOADING
Abstract

Aim: Musashi 2 (MSI2), which is an RNA-binding protein, plays a fundamental role in the oncogenesis of several cancers. The aim of this study is to investigate the expression of MSI2 in Oral Squamous Cell Carcinoma (OSCC) and evaluate its correlation to clinic-pathological variables and prognosis. Materials and Methods: A bioinformatic analysis was performed on data downloaded from The Cancer Genome Atlas (TCGA) database. The MSI2 expression data were analysed for their correlation with clinic-pathological and prognostic features. In addition, an immmunohistochemical evaluation of MSI2 expression on 108 OSCC samples included in a tissue microarray and 13 healthy mucosae samples was performed. Results: 241 patients' data from TCGA were included in the final analysis. No DNA mutations were detected for the MSI2 gene, but a hyper methylated condition of the gene emerged. MSI2 mRNA expression correlated with Grading (p = 0.009) and overall survival (p = 0.045), but not with disease free survival (p = 0.549). Males presented a higher MSI2 mRNA expression than females. The immunohistochemical evaluation revealed a weak expression of MSI2 in both OSCC samples and in healthy oral mucosae. In addition, MSI2 expression directly correlated with Cyclin-D1 expression (p = 0.022). However, no correlation has been detected with prognostic outcomes (overall and disease free survival). Conclusions: The role of MSI2 expression in OSCC seems to be not so closely correlated with prognosis, as in other human neoplasms. The correlation with Cyclin-D1 expression suggests an indirect role that MSI2 might have in the proliferation of OSCC cells, but further studies are needed to confirm such results. [ABSTRACT FROM AUTHOR]

Published
2020
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