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3. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS

Author

Hellbach, Fabian, Sinke, Lucy, Costeira, Ricardo, Baumeister, Sebastian-Edgar, Beekman, Marian, Louca, Panayiotis, Leeming, Emily R., Mompeo, Olatz, Berry, Sarah, Wilson, Rory, Wawro, Nina, Freuer, Dennis, Hauner, Hans, Peters, Annette, Winkelmann, Juliane, Koenig, Wolfgang, Meisinger, Christa, Waldenberger, Melanie, Heijmans, Bastiaan T., Slagboom, P. Eline, Bell, Jordana T., and Linseisen, Jakob

Published
2023
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5. The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery

Author

Louca, Panayiotis, Meijnikman, Abraham S., Nogal, Ana, Asnicar, Francesco, Attaye, Ilias, Vijay, Amrita, Kouraki, Afroditi, Visconti, Alessia, Wong, Kari, Berry, Sarah E., Leeming, Emily R., Mompeo, Olatz, Tettamanzi, Francesca, Baleanu, Andrei-Florin, Falchi, Mario, Hadjigeorgiou, George, Wolf, Jonathan, Acherman, Yair I.Z., Van de Laar, Arnold W., Gerdes, Victor E.A., Michelotti, Gregory A., Franks, Paul W., Segata, Nicola, Mangino, Massimo, Spector, Tim D., Bulsiewicz, William J., Nieuwdorp, Max, Valdes, Ana M., and Menni, Cristina

Published
2023
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10. Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study

Author

Menni, Cristina, Valdes, Ana M, Polidori, Lorenzo, Antonelli, Michela, Penamakuri, Satya, Nogal, Ana, Louca, Panayiotis, May, Anna, Figueiredo, Jane C, Hu, Christina, Molteni, Erika, Canas, Liane, Österdahl, Marc F, Modat, Marc, Sudre, Carole H, Fox, Ben, Hammers, Alexander, Wolf, Jonathan, Capdevila, Joan, Chan, Andrew T, David, Sean P, Steves, Claire J, Ourselin, Sebastien, and Spector, Tim D

Published
2022
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12. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study

Author

Menni, Cristina, Klaser, Kerstin, May, Anna, Polidori, Lorenzo, Capdevila, Joan, Louca, Panayiotis, Sudre, Carole H, Nguyen, Long H, Drew, David A, Merino, Jordi, Hu, Christina, Selvachandran, Somesh, Antonelli, Michela, Murray, Benjamin, Canas, Liane S, Molteni, Erika, Graham, Mark S, Modat, Marc, Joshi, Amit D, Mangino, Massimo, Hammers, Alexander, Goodman, Anna L, Chan, Andrew T, Wolf, Jonathan, Steves, Claire J, Valdes, Ana M, Ourselin, Sebastien, and Spector, Tim D

Published
2021
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16. Dietary Interventions Reduce Traditional and Novel Cardiovascular Risk Markers by Altering the Gut Microbiome and Their Metabolites

Author

Amrita Vijay, Stuart Astbury, Louca Panayiotis, Francine Z. Marques, Tim D. Spector, Cristina Menni, and Ana M. Valdes

Subjects
dietary intervention, short-chain fatty acids, gut microbiome, CVD risk factors, fibre, omega-3 fatty acids, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not yet been explored in humans.Methods and Results: Using a two-arm dietary intervention study in healthy participants (N = 70), we assessed the effects of omega-3 and fibre supplementation on gut microbiome composition and short-chain fatty acid (SCFA) production. We then investigated how changes in gut microbiome composition correlated with changes in traditional cardiovascular risk factors (cholesterol, triglycerides, blood pressure), cytokines, and novel validated markers such as GlycA and ceramides, previously linked to CVD incidence and mortality. Both interventions resulted in significant drops in blood pressure, cholesterol, proinflammatory cytokines, GlycA and ceramides (all P < 0.05). Decreases in the atherogenic low-density lipoprotein triglyceride fraction, in total serum cholesterol were correlated with increases in butyric acid-production [β(SE) = −0.58 (0.06), P < 0.001; −0.53 (0.04), P < 0.001] and nominally associated with increases in some butyrogenic bacteria. Drops in GlycA were linked to increases in Bifidobacterium [β(SE) = −0.32 (0.04), P = 0.02] and other SCFAs including acetic acid [β(SE) = −0.28 (0.04), P = 0.02] and propionic acid [β(SE) = −0.3 (0.04), P = 0.02]. Additionally, we report for the first-time reductions in specific ceramide ratios that have been shown to predict CVD mortality and major adverse cardiovascular events such as d18:1/16:0, d18:0/24:0, and d18:1/24:1 which were associated with the reduction in the abundance in Colinsella and increases in Bifidobacteriuim and Coprococcus 3 and SCFAs (all P < 0.05).Conclusion: Overall, these findings support the potential of using simple dietary interventions to alter validated biomarkers linked to cardiovascular risk via the gut microbiome composition and its metabolic functions.

Published
2021
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19. A faecal metabolite signature of impaired fasting glucose: results from two independent population-based cohorts

Author

Nogal, Ana, primary, Tettamanzi, Francesca, primary, Dong, Qiuling, primary, Louca, Panayiotis, primary, Visconti, Alessia, primary, Christiansen, Colette, primary, Breuninger, Taylor, primary, Linseisen, Jakob, primary, Grallert, Harald, primary, Wawro, Nina, primary, Asnicar, Francesco, primary, Wong, Kari, primary, Baleanu, Andrei-Florin, primary, A. Michelotti, Gregory, primary, Segata, Nicola, primary, Falchi, Mario, primary, Peters, Annette, primary, W. Franks, Paul, primary, Bagnardi, Vincenzo, primary, D Spector, Tim, primary, T Bell, Jordana, primary, Gieger, Christian, primary, M Valdes, Ana, primary, and Menni, Cristina, primary

Published
2023
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20. Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation

Author

Nogal, Ana, primary, Asnicar, Francesco, additional, Vijay, Amrita, additional, Kouraki, Afroditi, additional, Visconti, Alessia, additional, Louca, Panayiotis, additional, Wong, Kari, additional, Baleanu, Andrei-Florin, additional, Giordano, Francesca, additional, Wolf, Jonathan, additional, Hadjigeorgiou, George, additional, Davies, Richard, additional, Michelotti, Gregory A., additional, Franks, Paul W., additional, Berry, Sarah E., additional, Falchi, Mario, additional, Ikram, Adeel, additional, Ollivere, Benjamin J., additional, Zheng, Amy, additional, Nightingale, Jessica, additional, Mangino, Massimo, additional, Segata, Nicola, additional, Bulsiewicz, William J., additional, Spector, Tim D., additional, Valdes, Ana M., additional, and Menni, Cristina, additional

Published
2023
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22. A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts.

Author

Nogal, Ana, Tettamanzi, Francesca, Dong, Qiuling, Louca, Panayiotis, Visconti, Alessia, Christiansen, Colette, Breuninger, Taylor, Linseisen, Jakob, Grallert, Harald, Wawro, Nina, Asnicar, Francesco, Wong, Kari, Baleanu, Andrei-Florin, Michelotti, Gregory A., Segata, Nicola, Falchi, Mario, Peters, Annette, Franks, Paul W., Bagnardi, Vincenzo, and Spector, Tim D.

Subjects
GUT microbiome, MICROBIAL metabolites, TYPE 2 diabetes, INTESTINAL absorption, GLUCOSE
Abstract

Prediabetes is a metabolic condition associated with gut microbiome composition, although mechanisms remain elusive. We searched for fecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individuals with IFG and 1,105 healthy individuals from the UK Adult Twin Registry (TwinsUK). We used the Cooperative Health Research in the Region of Augsburg (KORA) cohort (318 IFG individuals, 689 healthy individuals) to replicate our findings. We linearly combined eight IFG-positively associated metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, caffeine, and protoporphyrin IX) into an IFG-metabolite score, which was significantly associated with higher odds ratios (ORs) for IFG (TwinsUK: OR 3.9 [95% CI 3.02–5.02], P < 0.0001, KORA: OR 1.3 [95% CI 1.16–1.52], P < 0.0001) and incident type 2 diabetes (T2D; TwinsUK: hazard ratio 4 [95% CI 1.97–8], P = 0.0002). Although these are host-produced metabolites, we found that the gut microbiome is strongly associated with their fecal levels (area under the curve >70%). Abundances of Faecalibacillus intestinalis, Dorea formicigenerans, Ruminococcus torques, and Dorea sp. AF24-7LB were positively associated with IFG, and such associations were partially mediated by 1-methylxanthine and nicotinate (variance accounted for mean 14.4% [SD 5.1], P < 0.05). Our results suggest that the gut microbiome is linked to prediabetes not only via the production of microbial metabolites but also by affecting intestinal absorption/excretion of host-produced metabolites and xenobiotics, which are correlated with the risk of IFG. Fecal metabolites enable modeling of another mechanism of gut microbiome effect on prediabetes and T2D onset. Article Highlights: Prediabetes is a metabolic condition associated with gut microbiome composition, although mechanisms remain elusive. We investigated whether there is a fecal metabolite signature of impaired fasting glucose (IFG) and the possible underlying mechanisms of action. We identified a fecal metabolite signature of IFG associated with prevalent IFG in two independent cohorts and incident type 2 diabetes in a subanalysis. Although the signature consists of metabolites of nonmicrobial origin, it is strongly correlated with gut microbiome composition. Fecal metabolites enable modeling of another mechanism of gut microbiome effect on prediabetes by affecting intestinal absorption or excretion of host compounds and xenobiotics. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Additional file 3 of Plasma protein N-glycome composition associates with postprandial lipaemic response

Author

Louca, Panayiotis, Štambuk, Tamara, Frkatović-Hodžić, Azra, Nogal, Ana, Mangino, Massimo, Berry, Sarah E., Deriš, Helena, Hadjigeorgiou, George, Wolf, Jonathan, Vinicki, Martina, Franks, Paul W., Valdes, Ana M., Spector, Tim D., Lauc, Gordan, and Menni, Cristina

Abstract

Additional file 3: Supplementary Table 1. List of glycan structures corresponding to every individual plasma protein glycan peak. Supplementary Table 2. Plasma protein derived glycan traits calculated out of 39 initial plasma glycan peaks. Supplementary Table 3. Associations between plasma protein N-glycome and triglycerides. Supplementary Table 4. Associations between plasma protein N-glycome and glucose. Supplementary table 5. Associations between plasma protein N-glycome and insulin.

Published
2023
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26. Additional file 2 of Plasma protein N-glycome composition associates with postprandial lipaemic response

Author

Louca, Panayiotis, Štambuk, Tamara, Frkatović-Hodžić, Azra, Nogal, Ana, Mangino, Massimo, Berry, Sarah E., Deriš, Helena, Hadjigeorgiou, George, Wolf, Jonathan, Vinicki, Martina, Franks, Paul W., Valdes, Ana M., Spector, Tim D., Lauc, Gordan, and Menni, Cristina

Abstract

Additional file 2: Supplementary Figure 1. Representative HILIC-UPLC-FLR chromatogram of plasma protein N-glycome. Supplementary Figure 2. Association of plasma glycans with postprandial glucose and insulin levels. Supplementary Figure 3. The variance explained for glycaemic response and insulin response across various prediction models.

Published
2023
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27. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS

Author

Hellbach, Fabian, primary, Sinke, Lucy, additional, Costeira, Ricardo, additional, Baumeister, Sebastian-Edgar, additional, Beekman, Marian, additional, Louca, Panayiotis, additional, Leeming, Emily R., additional, Mompeo, Olatz, additional, Berry, Sarah, additional, Wilson, Rory, additional, Wawro, Nina, additional, Freuer, Dennis, additional, Hauner, Hans, additional, Peters, Annette, additional, Winkelmann, Juliane, additional, Koenig, Wolfgang, additional, Meisinger, Christa, additional, Waldenberger, Melanie, additional, Heijmans, Bastiaan T., additional, Slagboom, P. Eline, additional, Bell, Jordana T., additional, and Linseisen, Jakob, additional

Published
2022
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30. Cross-Sectional Blood Metabolite Markers of Hypertension: A Multicohort Analysis of 44,306 Individuals from the COnsortium of METabolomics Studies

Author

Louca, Panayiotis, primary, Nogal, Ana, additional, Moskal, Aurélie, additional, Goulding, Neil J., additional, Shipley, Martin J., additional, Alkis, Taryn, additional, Lindbohm, Joni V., additional, Hu, Jie, additional, Kifer, Domagoj, additional, Wang, Ni, additional, Chawes, Bo, additional, Rexrode, Kathryn M., additional, Ben-Shlomo, Yoav, additional, Kivimaki, Mika, additional, Murphy, Rachel A., additional, Yu, Bing, additional, Gunter, Marc J., additional, Suhre, Karsten, additional, Lawlor, Deborah A., additional, Mangino, Massimo, additional, and Menni, Cristina, additional

Published
2022
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33. Additional file 3 of Characterisation, procedures and heritability of acute dietary intake in the Twins UK cohort: an observational study

Author

Leeming, Emily R., Mompeo, Olatz, Turk, Pauline, Bowyer, Ruth C. E., Louca, Panayiotis, Johnson, Abigail J., Spector, Tim D., Le Roy, Caroline, and Gibson, Rachel

Abstract

Additional file 3: Supplementary Table 2. Two-sided Spearman���s correlation test comparing energy adjusted nutrient output of EFR vs FFQ (n = 1224).

Published
2022
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36. Incremental Value of a Panel of Serum Metabolites for Predicting Risk of Atherosclerotic Cardiovascular Disease

Author

Nogal, Ana, primary, Louca, Panayiotis, additional, Tran, Tran Quoc Bao, additional, Bowyer, Ruth C., additional, Christofidou, Paraskevi, additional, Steves, Claire J., additional, Berry, Sarah E., additional, Wong, Kari, additional, Wolf, Jonathan, additional, Franks, Paul W., additional, Mangino, Massimo, additional, Spector, Tim D., additional, Valdes, Ana M., additional, Padmanabhan, Sandosh, additional, and Menni, Cristina, additional

Published
2022
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37. A Comparison of Symptom Prevalence, Severity and Duration in the SARS-CoV-2 Omicron Versus Delta Variants Among Vaccinated Individuals from the ZOE COVID Study

Author

Menni, Cristina, primary, Valdes, Ana, additional, Polidori, Lorenzo, additional, Antonelli, Michela, additional, Penamakuri, Satya, additional, Nogal, Ana, additional, Louca, Panayiotis, additional, May, Anna, additional, Figueiredo, Jane C., additional, Hu, Christina, additional, Molteni, Erika, additional, Canas, Liane S., additional, Österdahl, Marc F., additional, Modat, Marc, additional, Sudre-Ferraris, Carole, additional, Fox, Ben, additional, Hammers, Alexander, additional, Wolf, Jonathan, additional, Capdevila, Joan, additional, Chan, Andrew T., additional, David, Sean, additional, Steves, Claire J., additional, Ourselin, Sebastien, additional, and Spector, Tim D., additional

Published
2022
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38. Contributors

Author

Ahmed, Farah, Armstrong, Catherine, Bakalakos, Athanasios, Balasubramanian, Meena, Baritussio, Anna, Bhatia, Raghav T., Bogaard, Harm J., Bogaard, Harm Jan, Boomars, Karin A., Bueser, Teofila, Caforio, Alida LP., Carmo-Fonseca, M., Carvalho, Teresa, Celant, Lucas R., Chatrath, Nikhil, Cornel, Martina C., Dooijes, Dennis, du Toit, Clea, Elliott, Perry Mark, Furtado, Marta, Giordani, Andrea Silvio, Houweling, Arjan C., Iliceto, Sabino, Jansen, Samara M.A., Kassi, Maria, Koudstaal, Thomas, Kukavica, Deni, Kumar, Dhavendra, Lambiase, Pier D., Loeys, Bart L., Louca, Panayiotis, Lovering, Ruth C., Malfait, Fransiska, Marcolongo, Renzo, Markus, Hugh Stephen, Martins, Sandra, Menni, Cristina, Mercer, Catherine L., Monserrat, Lorenzo, Munroe, Patricia B., Nogal, Ana, Olczak, Kaya, Padmanabhan, Sandosh, Papadakis, Michael, Perkins, Jonathan A., Pilichou, Kalliopi, Priori, Silvia G., Ribeiro, Marta, Sharma, Sanjay, Tan, Rhea Yan Ying, Valdes, Ana M., van de Beek, Irma, van der Crabben, Saskia N., Van Gucht, Ilse, Verstraeten, Aline, Wilson, Dirk G., and Young, William J.

Published
2024
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39. A High Protein Diet Is More Effective in Improving Insulin Resistance and Glycemic Variability Compared to a Mediterranean Diet—A Cross-Over Controlled Inpatient Dietary Study

Author

Tettamanzi, Francesca, primary, Bagnardi, Vincenzo, additional, Louca, Panayiotis, additional, Nogal, Ana, additional, Monti, Gianna Serafina, additional, Mambrini, Sara P., additional, Lucchetti, Elisa, additional, Maestrini, Sabrina, additional, Mazza, Silvia, additional, Rodriguez-Mateos, Ana, additional, Scacchi, Massimo, additional, Valdes, Ana M., additional, Invitti, Cecilia, additional, and Menni, Cristina, additional

Published
2021
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42. Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app

Author

Louca, Panayiotis, Murray, Benjamin, Klaser, Kerstin, Graham, Mark S, Mazidi, Mohsen, Leeming, Emily R, Thompson, Ellen, Bowyer, Ruth, Drew, David A, Nguyen, Long H, Merino, Jordi, Gomez, Maria, Mompeo, Olatz, Costeira, Ricardo, Sudre, Carole H, Gibson, Rachel, Steves, Claire J, Wolf, Jonathan, Franks, Paul W, Ourselin, Sebastien, Chan, Andrew T, Berry, Sarah E, Valdes, Ana M, Calder, Philip C, Spector, Tim D, and Menni, Cristina

Subjects
0301 basic medicine, medicine.medical_specialty, Health (social science), RC620-627, Population, Medicine (miscellaneous), Lower risk, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Vitamin D and neurology, 030212 general & internal medicine, nutritional treatment, education, Nutritional diseases. Deficiency diseases, Original Research, 2. Zero hunger, education.field_of_study, Nutrition and Dietetics, Vitamin C, business.industry, Confounding, COVID-19, 3. Good health, 030104 developmental biology, Observational study, business, Multivitamin, Body mass index
Abstract

ObjectivesDietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection.DesignApp-based community survey.Setting445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373).Main exposureSelf-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020.Main outcome measuresSARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020.ResultsIn 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts.ConclusionIn women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.

Published
2021

44. Vaccine after Effects and Post-Vaccine Infection in a Real World Setting: Results from the COVID Symptom Study App

Author

Menni, Cristina, primary, Klaser, Kerstin, additional, May, Anna, additional, Polidori, Lorenzo, additional, Capdevila, Joan, additional, Louca, Panayiotis, additional, Sudre-Ferraris, Carole, additional, Nguyen, Long H., additional, Drew, David A., additional, Merino, Jordi, additional, Antonelli, Michela, additional, Murray, Benjamin, additional, Canas, Liane S., additional, Molteni, Erika, additional, Graham, Mark S., additional, Modat, Marc, additional, Joshi, Amit D., additional, Mangino, Massimo, additional, Hammers, Alexander, additional, Spector, Tim D., additional, Valdes, Ana M., additional, Goodman, Anna L., additional, Chan, Andrew T., additional, Wolf, Jonathan, additional, Steves, Claire, additional, Ourselin, Sebastien, additional, and Spector, Tim, additional

Published
2021
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46. Dietary supplements during the COVID-19 pandemic: insights from 1.4M users of the COVID Symptom Study app - a longitudinal app-based community survey

Author

Louca, Panayiotis, primary, Murray, Benjamin, additional, Klaser, Kerstin, additional, Graham, Mark S, additional, Mazidi, Mohsen, additional, Leeming, Emily R, additional, Thompson, Ellen, additional, Bowyer, Ruth, additional, Drew, David A, additional, Nguyen, Long H, additional, Merino, Jordi, additional, Gomez, Maria, additional, Mompeo, Olatz, additional, Costeira, Ricardo, additional, Sudre, Carole H, additional, Gibson, Rachel, additional, Steves, Claire J, additional, Wolf, Jonathan, additional, Franks, Paul W, additional, Ourselin, Sebastien, additional, Chan, Andrew T, additional, Berry, Sarah E, additional, Valdes, Ana M, additional, Calder, Philip C, additional, Spector, Tim D, additional, and Menni, Cristina, additional

Published
2020
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47. Body mass index mediates the effect of the DASH diet on hypertension: Common metabolites underlying the association.

Author

Louca, Panayiotis, Nogal, Ana, Mompeo, Olatz, Christofidou, Paraskevi, Gibson, Rachel, Spector, Tim D., Berry, Sarah E., Valdes, Ana M., Mangino, Massimo, and Menni, Cristina

Subjects
*HYPERTENSION, *CONFIDENCE intervals, *RANDOM forest algorithms, *TREATMENT effectiveness, *MOLECULAR biology, *DASH diet, *FACTOR analysis, *DESCRIPTIVE statistics, *PHENYLPROPIONATES, *PROLINE, *BODY mass index, *ODDS ratio, *METABOLITES
Abstract

Background: The Dietary Approaches to Stop Hypertension (DASH) diet is beneficial in reducing blood pressure; however, this may be a consequence of concurrent weight reduction. In the present study, we investigated whether body mass index (BMI) mediates the association between the DASH diet and hypertension and investigate common metabolic pathways. Methods: We included 2424 females from the cross‐sectional TwinsUK cohort, with blood pressure, BMI and dietary intake measured within 1.01 (SD = 0.68) years and serum metabolomics profiling (591 metabolites). We constructed a mediation model to test the mediation effects of BMI on the total effect of the DASH diet on hypertension. To identify a metabolite panel associated with the DASH diet and BMI, we built random forest models for each trait, and selected the common metabolic contributors using five‐fold cross‐validation error. Results: We found that BMI fully mediates the association between the DASH diet and hypertension, explaining 39.1% of the variance in hypertension. We then identified a panel of six common metabolites predicting both the DASH diet and BMI with opposing effects. Interestingly, at the univariate level, the metabolites were also associated with hypertension in the same direction as BMI. The strongest feature, 1‐nonadecanoyl‐GPC (19:0), was positively associated with the DASH diet (β [SE] = 0.65 [0.12]) and negatively with BMI (β [SE] = −1.34 [0.12]) and hypertension (odds ratio = 0.71, 95% confidence interval = 0.6–0.84). Conclusions: We highlight the role of BMI in the mechanisms by which the DASH diet influences hypertension and also highlight common metabolic pathways. Further studies should investigate the underlying molecular mechanisms to increase our understanding of the beneficial ways of treating hypertension. Key points: Adherence to the DASH diet can reduce blood pressure; however, this may be a consequence of concurrent weight reduction.In a large sample of 2424 females from TwinsUK, we report that BMI fully mediates the association between the DASH diet and hypertension, explaining 39.1% of the variance in hypertension.We also identify a panel of six common metabolites predicting both the DASH diet and BMI with opposing effects, highlighting common metabolic pathways.Further studies should investigate the underlying molecular mechanisms to increase our understanding of the beneficial ways of treating hypertension. [ABSTRACT FROM AUTHOR]

Published
2022
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