347 results on '"Louisse, Jochem"'
Search Results
2. Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
3. Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)
4. Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells
5. Chlorinated paraffins (CPs) in vegetable oils from the Dutch market and the effects of the refining process on their levels
6. A computational study on the biotransformation of alkenylbenzenes by a selection of CYPs: Reflections on their possible bioactivation
7. Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids
8. Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations
9. Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells
10. Development of a framework to derive effect-based trigger values to interpret CALUX data for drinking water quality
11. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling
12. Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry
13. Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells
14. Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites.
15. Metabolites in the regulatory risk assessment of pesticides in the EU
16. TKPlate 1.0: An Open‐access platform for toxicokinetic and toxicodynamic modelling of chemicals to implement new approach methodologies in chemical risk assessment
17. Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)
18. Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions
19. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells
20. Putative adverse outcome pathways relevant to neurotoxicity
21. Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
22. The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy
23. Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine
24. Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes
25. Prenatal developmental toxicity testing of petroleum substances: Application of the mouse embryonic stem cell test (EST) to compare in vitro potencies with potencies observed in vivo
26. Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing
27. Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action
28. Assessment of acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes
29. In vitro bioassays to evaluate beneficial and adverse health effects of botanicals: promises and pitfalls
30. Risk assessment for pyrrolizidine alkaloids detected in (herbal) teas and plant food supplements
31. Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats
32. Ethnomedicine and ethnobotany of Maerua subcordata (Gilg) DeWolf
33. Selecting the dose metric in reverse dosimetry based QIVIVE: Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02421-w
34. Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
35. New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs
36. A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species
37. Correction to: Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells
38. Translocation of positively and negatively charged polystyrene nanoparticles in an in vitro placental model
39. Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds
40. Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)
41. Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells
42. Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling
43. Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
44. Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations
45. Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds
46. Providing Biological Plausibility for Exposure–Health Relationships for the Mycotoxins Deoxynivalenol (DON) and Fumonisin B1 (FB1) in Humans Using the AOP Framework
47. Predictive performance of next generation human physiologically based kinetic (PBK) models based on in vitro and in silico input data
48. Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
49. A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism
50. Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity
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