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2. The role of cerebral small vessel disease in dementia

Author

Low, Audrey, O'Brien, John T., and Markus, Hugh S.

Subjects
Alzheimer's disease, amyloid, APOE4, cerebral small vessel disease, dementia, inflammation, MRI, neuroimaging, risk factors, tau, vascular disease, white matter hyperintensities
Abstract

Introduction: Cerebral small vessel disease (SVD) is increasingly recognised as a key factor in dementia and cognitive impairment, although its role in the pathogenesis of Alzheimer's disease (AD) remains poorly understood. Through the investigation of how SVD relates and interacts with (1) molecular AD pathologies and (2) early midlife risk factors of dementia, this body of work aims to advance our understanding of SVD in relation to AD. Methods: In two separate cohorts, SVD was quantified on 3T MRI through the assessment of white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMB), and lacunes. Regional data on SVD location was used to derive composite scores for global SVD burden, and the SVD subtypes of hypertensive arteriopathy and cerebral amyloid angiopathy. The first objective was investigated in the Neuroimaging of Inflammation in Memory and Other Disorders (NIMROD) study, which consisted of multimodal PET imaging of older adults with varying degrees of clinical severity. Here, we investigated whether SVD was associated and interacted with the hallmark AD pathologies of amyloid, tau, and neuroinflammation (microglial activation) - these were quantified with PET imaging of [11C]PiB, [18F]AV-1451, and [11C]PK11195, respectively. For insights into the pre-clinical stages of AD pathogenesis, we examined cognitively healthy midlife adults from the PREVENT-Dementia study. We investigated whether well-established risk factors of late-life dementia were related to SVD burden much earlier on, at midlife. Results: SVD was associated with PET markers of neuroinflammation and tau, and plasma Aβ. Notably, associations with amyloid and tau markers were largely limited to WMH. In healthy middle-aged adults, inherited predisposition to dementia (APOE4, parental family history of dementia) was related to longitudinal SVD progression, but not baseline SVD severity. On the other hand, modifiable risk factors of late-life dementia were associated with midlife SVD burden. The two SVD subtypes were differentially related to AD pathologies and risk factors - neuroinflammation and modifiable risk factors were more closely associated with hypertensive arteriopathy, while amyloid and tau related more closely to cerebral amyloid angiopathy. Conclusions: Together, our findings implicate SVD in the early pathogenesis of AD and suggest that lifestyle modifications as early as midlife may reduce the vascular-driven component of AD. Findings highlight the need to further inspect the biological underpinnings of WMH and fluid markers of AD pathology.

Published
2022
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4. Associations Between Retinal Microvasculature Changes and Gray Matter Volume in a Mid-Life Cohort at Risk of Developing Alzheimer’s Disease

Author

Rashid, Darwon, Giarratano, Ylenia, Hamid, Charlene, MacGillivray, Tom, Terrera, Graciela Muniz, Ritchie, Craig, Dhillon, Baljean, Reid-Schachter, Megan, Low, Audrey, Dounavi, Maria-Eleni, O’Brien, John T., Bernabeu, Miguel O., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Antony, Bhavna, editor, Chen, Hao, editor, Fang, Huihui, editor, Fu, Huazhu, editor, Lee, Cecilia S., editor, and Zheng, Yalin, editor

Published
2023
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5. Socially Challenged Collaborative Learning of Secondary School Students in Singapore

Author

Pang, Christopher, Lau, Jesslyn, Seah, Chong Poh, Cheong, Linda, and Low, Audrey

Abstract

Using a grounded theory research design, this paper examined the collaborative learning experiences of secondary school students in Singapore. The core phenomenon that emerged was the need for social interactions in collaborative learning, both in classroom and online settings. Educators often take for granted that effective collaborative learning will occur naturally once students are assigned to work in groups. In examining students' dissatisfaction when working in groups, this study highlighted the importance of surfacing these hidden assumptions for careful scrutiny. The key factors identified were centered on the need to address social challenges within collaborative learning. These included a pragmatic, results-oriented approach with limited interpersonal engagement used by students that can compromise collaborative learning outcomes. Having a deeper understanding of the challenges that resulted from limited social interactions provides educators with insights when designing classroom and online learning activities. This paper contributes to the understanding of groups' active learning to inform pedagogical practices for educators engaged in designing better collaborative learning experiences. Educators and curriculum designers need to be aware of the social drawbacks in collaborative learning in order to design a more socially engaging learning environment.

Published
2018

6. Associations Between Retinal Microvasculature Changes and Gray Matter Volume in a Mid-Life Cohort at Risk of Developing Alzheimer’s Disease

Author

Rashid, Darwon, primary, Giarratano, Ylenia, additional, Hamid, Charlene, additional, MacGillivray, Tom, additional, Terrera, Graciela Muniz, additional, Ritchie, Craig, additional, Dhillon, Baljean, additional, Reid-Schachter, Megan, additional, Low, Audrey, additional, Dounavi, Maria-Eleni, additional, O’Brien, John T., additional, and Bernabeu, Miguel O., additional

Published
2023
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9. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos

Published
2022
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10. Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study

Author

Low, Audrey, Prats-Sedano, Maria A., McKiernan, Elizabeth, Carter, Stephen F., Stefaniak, James D., Nannoni, Stefania, Su, Li, Dounavi, Maria-Eleni, Muniz-Terrera, Graciela, Ritchie, Karen, Lawlor, Brian, Naci, Lorina, Malhotra, Paresh, Mackay, Clare, Koychev, Ivan, Ritchie, Craig W., Markus, Hugh S., and O’Brien, John T.

Published
2022
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11. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Dahou, Brahim, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra Lucia, Pinheiro, Marcelo, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Castro Coello, Vanessa, Haye Salinas, María J., Maldonado, Federico Nicolas, Reyes Torres, Alvaro Andres, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria Soledad, Medina, María Alejandra, Savio, Veronica, Rojas Tessel, Ivana Romina, Perez Alamino, Rodolfo, Werner, Marina Laura, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Ma. Alicia, Rodriguez Gil, Gustavo Fabián, Risueño, Fabian, Quaglia, Maria Isabel, Scafati, Julia, Cuchiaro, Natalia Lili, Rebak, Jonathan Eliseo, Pineda, Susana Isabel, Calvo, María Elena, Picco, Eugenia, Gallino Yanzi, Josefina, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta Silvana, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José Luis, Kisluk, Boris, Castaños Menescardi, Maria Sol, Gallo, Rosana, Martire, María Victoria, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina Solange, Aeschlimann, Carolina, Subils, Gisela, Ibáñez, Sebastián, Chassin-Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešic, Marko, Anic, Branimir, Culo, Melanie-Ivana, Pavelic, Tea Ahel, Kovacevic Stranski, Kristina, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela Maria, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir-Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zaueta, Beatriz, Castillo Ortiz, Angel Alejandro, Zamora Tehozol, Erick, Vega, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez-Reyna, Tatiana Sofia, Rull Gabayet, Marina, Alpízar-Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts-van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al-Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte-Gil, Manuel, Nowakowski, Jaroslaw, Al-Emadi, Samar, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria Magdelena, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Miceková, Dagmar, Capova, Lubica, Macejova, Zelmira, Štenová, Emoke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Sencarová, Marieta, Žlnayová, Sona, Anna Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre-Rubio, Natalia, Alegre Sancho, Juan José, Corteguera Coro, Montserrat, Cobeta Garcia, Juan Carlos, Torres Martin, Maria Carmen, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd Kubra, Akar, Servet, Icacan, Ozan Cemal, Çelik, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline Mulvaney, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, D'Silva, Kristin, Hsu, Tiffany, Patel, Naomi, Sparks, Jeffrey, Todd, Derrick, Wallace, Zachary, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Wise, Leanna, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio Toribio, Karen, Webb-Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Fatemeh, Ezzati, Parks, Deborah, Karp, David, Quiceno, Guillermo, Sattui, Sebastian E, Putman, Michael S, Seet, Andrea M, Gianfrancesco, Milena A, Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L, Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Mariz, Henrique Ataide, de Sousa Studart, Samia Araujo, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stéphane, Maria, Alexandre TJ, Chazerain, Pascal, Hasseli, Rebecca, Müller-Ladner, Ulf, Hoyer, Bimba F, Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Sparks, Jeffrey A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-García, Alí, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S, Sufka, Paul, Bhana, Suleman, Liew, Jean W, Grainger, Rebecca, Machado, Pedro M, Wallace, Zachary S, Yazdany, Jinoos, and Robinson, Philip C

Published
2021
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12. The Mediterranean diet is not associated with neuroimaging or cognition in middle‐aged adults: a cross‐sectional analysis of the PREVENT dementia programme

Author

Gregory, Sarah, primary, Buller‐Peralta, Ingrid, additional, Bridgeman, Katie, additional, Góngora, Vanessa De La Cruz, additional, Dounavi, Maria‐Eleni, additional, Low, Audrey, additional, Ntailianis, Georgios, additional, O'Brien, John, additional, Parra, Mario A., additional, Ritchie, Craig W., additional, Ritchie, Karen, additional, Shannon, Oliver M., additional, Stevenson, Emma J., additional, and Muniz‐Terrera, Graciela, additional

Published
2024
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17. Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT‐Dementia study.

Author

Gibbon, Samuel, Low, Audrey, Hamid, Charlene, Reid‐Schachter, Megan, Muniz‐Terrera, Graciela, Ritchie, Craig W., Trucco, Emanuele, Dhillon, Baljean, O'Brien, John T., and MacGillivray, Thomas J.

Subjects
CEREBRAL small vessel diseases, OPTIC disc, MIDDLE-aged persons, MAGNETIC resonance imaging, OPTICAL coherence tomography
Abstract

INTRODUCTION: We tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, microbleeds, white matter hyperintensities, and enlarged perivascular spaces [ePVSs]). METHODS: We used PallorMetrics to quantify optic disc pallor from fundus photographs, and pRNFL thickness from optical coherence tomography scans. Linear and logistic regression assessed relationships between retinal measures and SVD markers. Participants (N = 108, mean age 51.6) were from the PREVENT Dementia study. RESULTS: Global optic disc pallor was linked to ePVSs in the basal ganglia in both left (β = 0.12, standard error [SE] = 0.05, P < 0.05) and right eyes (β = 0.13, SE = 0.05, P < 0.05). Associations were also noted in different disc sectors. No pRNFL associations with SVD markers were found. DISCUSSION: Optic disc pallor correlated with ePVSs in the basal ganglia, suggesting retinal examination may be a useful method to study brain health changes related to SVD. Highlights: Optic disc pallor is linked to enlarged perivascular spaces in basal ganglia.There is no association between peripapillary retinal nerve fiber layer thickness and cerebral small vessel disease markers.Optic disc examination could provide insights into brain health.The sample included 108 midlife adults from the PREVENT Dementia study. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Immune regulation and blood–brain barrier permeability in cerebral small vessel disease: study protocol of the INflammation and Small Vessel Disease (INSVD) study – a multicentre prospective cohort study

Author

Low, Audrey, primary, van Winden, Sanne, additional, Cai, Lupei, additional, Kessels, Roy P C, additional, Maas, Marnix C, additional, Morris, Robin G, additional, Nus, Meritxell, additional, Tozer, Daniel J, additional, Tuladhar, Anil, additional, van der Kolk, Anja, additional, Wolters, Rowan, additional, Mallat, Ziad, additional, Riksen, Niels P, additional, Markus, Hugh, additional, and de Leeuw, Frank‐Erik, additional

Published
2024
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19. Investigating the impact of APOE4 genotype on the association between cerebral blood flow and haematological properties in mid‐life adults

Author

Dounavi, Maria‐Eleni, primary, Mak, Elijah, additional, Low, Audrey, additional, Williams, Guy B, additional, Wells, Katie, additional, Muniz‐Terrera, Graciela, additional, Lawlor, Brian A, additional, Naci, Lorina, additional, Malhotra, Paresh A, additional, Koychev, Ivan, additional, Ritchie, Karen, additional, Su, Li, additional, Ritchie, Craig W, additional, and O'Brien, John T, additional

Published
2023
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20. Apoe ε4 exacerbates age‐dependent decline of cortical microstructural changes in cognitively normal midlife individuals: the PREVENT‐Dementia and ALFA studies

Author

Mak, Elijah, primary, Dounavi, Maria‐Eleni, additional, Operto, Grégory, additional, Ziukelis, Elina T, additional, Jones, P Simon, additional, Low, Audrey, additional, Swann, Peter, additional, Newton, Coco, additional, Muniz‐Terrera, Graciela, additional, Malhotra, Paresh A, additional, Koychev, Ivan, additional, Falcon, Carles, additional, Mackay, Clare, additional, Lawlor, Brian, additional, Naci, Lorina, additional, Wells, Katie, additional, Ritchie, Craig W, additional, Ritchie, Karen, additional, Su, Li, additional, Gispert, Juan Domingo, additional, and O'Brien, John T, additional

Published
2023
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21. Dietary patterns, cardiometabolic and brain health in the PREVENT Dementia Cohort

Author

Gregory, Sarah, primary, Dounavi, Maria‐Eleni, additional, Low, Audrey, additional, Ntailianis, Georgios, additional, O'Brien, John T, additional, Parra‐Rodriguez, Mario A, additional, Shannon, Oliver M, additional, Stevenson, Emma, additional, Ritchie, Craig W, additional, Ritchie, Karen, additional, Wells, Katie, additional, and Muniz‐Terrera, Graciela, additional

Published
2023
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22. DNA methylation alterations in Lewy Body Dementia

Author

Chouliaras, Leonidas, primary, Thomas, Alan J, additional, Clark, Graeme, additional, Donaghy, Paul C, additional, Swann, Peter, additional, Malpetti, Maura, additional, Mak, Elijah, additional, Savulich, George, additional, Prats‐Sedano, Maria A, additional, Low, Audrey, additional, Su, Li, additional, Rowe, James B., additional, and O'Brien, John T, additional

Published
2023
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23. Cerebral microbleeds in traumatic brain injury associated with differential risk factors and clinical outcomes: the PREVENT‐Dementia study

Author

Low, Audrey, primary, McKiernan, Elizabeth, additional, Prats‐Sedano, Maria A, additional, Carter, Stephen F, additional, Stefaniak, James D, additional, Su, Li, additional, Dounavi, Maria‐Eleni, additional, Muniz‐Terrera, Graciela, additional, Jenkins, Natalie D, additional, Ritchie, Karen, additional, Lawlor, Brian, additional, Naci, Lorina, additional, Malhotra, Paresh A, additional, Thayanandan, Tony, additional, Mackay, Clare, additional, Koychev, Ivan, additional, Raymont, Vanessa, additional, Ritchie, Craig W, additional, and O'Brien, John T, additional

Published
2023
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26. The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia.

Author

Ritchie, Craig W, Bridgeman, Katie, Gregory, Sarah, O'Brien, John T, Danso, Samuel O, Dounavi, Maria-Eleni, Carriere, Isabelle, Driscoll, David, Hillary, Robert, Koychev, Ivan, Lawlor, Brian, Naci, Lorina, Su, Li, Low, Audrey, Mak, Elijah, Malhotra, Paresh, Manson, Jean, Marioni, Riccardo, Murphy, Lee, and Ntailianis, Georgios

Published
2024
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27. Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults

Author

Buller-Peralta, Ingrid, primary, Gregory, Sarah, additional, Low, Audrey, additional, Dounavi, Maria-Eleni, additional, Wells, Katie, additional, Ntailianis, Georgios, additional, Lawlor, Brian, additional, Naci, Lorina, additional, Koychev, Ivan, additional, Malhotra, Paresh, additional, O'Brien, John T, additional, Ritchie, Craig W, additional, and Terrera, Graciela Muniz, additional

Published
2023
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29. LipidSIM: inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, systematic Markov Modeling framework

Author

Liang, Chenguang, primary, Murray, Sue, additional, Li, Yang, additional, Lee, Richard, additional, Low, Audrey, additional, Sasaki, Shruti, additional, Chiang, Austin W.T., additional, Lin, Wen-Jen, additional, Mathews, Joel, additional, Barnes, Will, additional, and Lewis, Nathan E., additional

Published
2023
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30. The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

Author

Ritchie, Craig W., primary, Wells, Katie, additional, Gregory, Sarah, additional, Carriere, Isabelle, additional, Danso, Samuel O., additional, Driscoll, David, additional, Dounavi, Maria-Eleni, additional, Hillary, Robert, additional, Koychev, Ivan, additional, Lawlor, Brian, additional, Li, Su, additional, Low, Audrey, additional, Mak, Elijah, additional, Malhotra, Paresh, additional, Manson, Jean, additional, Marioni, Riccardo, additional, Murphy, Lee, additional, Naci, Lorina, additional, O’Brien, John T, additional, Stewart, William, additional, Muniz-Terrera, Graciela, additional, and Ritchie, Karen, additional

Published
2023
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31. Mutation in the Glycosylated Gag Protein of Murine Leukemia Virus Results in Reduced In Vivo Infectivity and a Novel Defect in Viral Budding or Release▿

Author

Low, Audrey, Datta, Shoibal, Kuznetsov, Yurii, Jahid, Sohail, Kothari, Nayantara, McPherson, Alexander, and Fan, Hung

Subjects
Rare Diseases, Hematology, Infectious Diseases, Biotechnology, Genetics, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Infection, Animals, Cell Line, Codon, Nonsense, Fibroblasts, Gene Products, gag, Genome, Viral, Glycoproteins, Glycosylation, Leukemia Virus, Murine, Mice, Microscopy, Atomic Force, Models, Animal, Polymerase Chain Reaction, Sequence Analysis, DNA, Viral Structural Proteins, Virus Replication, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

All gammaretroviruses, including murine leukemia viruses (MuLVs), feline leukemia viruses, and gibbon-ape leukemia virus, encode an alternate, glycosylated form of Gag polyprotein (glyco-Gag or gPr80gag) in addition to the polyprotein precursor of the viral capsid proteins (Pr65gag). gPr80gag is translated from an upstream in-frame CUG initiation codon, in contrast to the AUG codon used for Pr65gag. The role of glyco-Gag in MuLV replication has been unclear, since gPr80gag-negative Moloney MuLV (M-MuLV) mutants are replication competent in vitro and pathogenic in vivo. However, reversion to the wild type is frequently observed in vivo. In these experiments, in vivo inoculation of a gPr80gag mutant, Ab-X-M-MuLV, showed substantially lower (2 log) initial infectivity in newborn NIH Swiss mice than that of wild-type virus, and revertants to the wild type could be detected by PCR cloning and DNA sequencing as early as 15 days postinfection. Atomic force microscopy of Ab-X-M-MuLV-infected producer cells or of the PA317 amphotropic MuLV-based vector packaging line (also gPr80gag negative) revealed the presence of tube-like viral structures on the cell surface. In contrast, wild-type virus-infected cells showed the typical spherical, 145-nm particles observed previously. Expression of gPr80gag in PA317 cells converted the tube-like structures to typical spherical particles. PA317 cells expressing gPr80gag produced 5- to 10-fold more infectious vector or viral particles as well. Metabolic labeling studies indicated that this reflected enhanced virus particle release rather than increased viral protein synthesis. These results indicate that gPr80gag is important for M-MuLV replication in vivo and in vitro and that the protein may be involved in a late step in viral budding or release.

Published
2007

32. APOE ɛ4 exacerbates age-dependent deficits in cortical microstructure.

Author

Mak, Elijah, Dounavi, Maria-Eleni, Operto, Grégory, Ziukelis, Elina T, Jones, Peter Simon, Low, Audrey, Swann, Peter, Newton, Coco, Terrera, Graciela Muniz, Malhotra, Paresh, Koychev, Ivan, Falcon, Carles, Mackay, Clare, Lawlor, Brian, Naci, Lorina, Wells, Katie, Ritchie, Craig, Ritchie, Karen, Su, Li, and Gispert, Juan Domingo

Published
2024
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34. Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review.

Author

Borchert, Robin J., Azevedo, Tiago, Badhwar, AmanPreet, Bernal, Jose, Betts, Matthew, Bruffaerts, Rose, Burkhart, Michael C., Dewachter, Ilse, Gellersen, Helena M., Low, Audrey, Lourida, Ilianna, Machado, Luiza, Madan, Christopher R., Malpetti, Maura, Mejia, Jhony, Michopoulou, Sofia, Muñoz‐Neira, Carlos, Pepys, Jack, Peres, Marion, and Phillips, Veronica

Abstract

Introduction: Artificial intelligence (AI) and neuroimaging offer new opportunities for diagnosis and prognosis of dementia. Methods: We systematically reviewed studies reporting AI for neuroimaging in diagnosis and/or prognosis of cognitive neurodegenerative diseases. Results: A total of 255 studies were identified. Most studies relied on the Alzheimer's Disease Neuroimaging Initiative dataset. Algorithmic classifiers were the most commonly used AI method (48%) and discriminative models performed best for differentiating Alzheimer's disease from controls. The accuracy of algorithms varied with the patient cohort, imaging modalities, and stratifiers used. Few studies performed validation in an independent cohort. Discussion: The literature has several methodological limitations including lack of sufficient algorithm development descriptions and standard definitions. We make recommendations to improve model validation including addressing key clinical questions, providing sufficient description of AI methods and validating findings in independent datasets. Collaborative approaches between experts in AI and medicine will help achieve the promising potential of AI tools in practice. Highlights: There has been a rapid expansion in the use of machine learning for diagnosis and prognosis in neurodegenerative diseaseMost studies (71%) relied on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset with no other individual dataset used more than five timesThere has been a recent rise in the use of more complex discriminative models (e.g., neural networks) that performed better than other classifiers for classification of AD vs healthy controlsWe make recommendations to address methodological considerations, addressing key clinical questions, and validationWe also make recommendations for the field more broadly to standardize outcome measures, address gaps in the literature, and monitor sources of bias [ABSTRACT FROM AUTHOR]

Published
2023
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36. Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design

Author

Brown, Robin, Low, Audrey, Markus, Hugh S, Brown, Robin [0000-0003-0431-7841], Low, Audrey [0000-0002-2520-454X], Markus, Hugh S [0000-0002-9794-5996], and Apollo - University of Cambridge Repository

Subjects
medicine.medical_specialty, Population, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, mental disorders, medicine, Humans, education, Clinical Trials as Topic, education.field_of_study, business.industry, Surrogate endpoint, Clinical study design, White Matter, Hyperintensity, Clinical trial, Psychiatry and Mental health, Research Design, Sample size determination, Cerebral Small Vessel Diseases, Meta-analysis, Population study, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

BackgroundWhite matter hyperintensities (WMHs) are a highly prevalent MRI marker of cerebral small vessel disease (SVD), which predict stroke and dementia risk, and are being increasingly used as a surrogate marker in clinical trials. However, the influence of study population selection on WMH progression rate has not been studied and the effect of individual patient factors for WMH growth are not fully understood.MethodsWe performed a systematic review and meta-analysis of the literature on progression of WMHs in longitudinal studies to determine rates of WMH growth, and how these varied according to population characteristics and cardiovascular risk factors. We used these data to calculate necessary sample sizes for clinical trials using WMH as an endpoint.ResultsWMH growth rate was highest in SVD (2.50cc/year), intermediate in unselected stroke patients (1.29cc/year) and lower in patients with non-stroke cardiovascular disease, and with cognitive impairment. Age was significantly associated with progression (correlation coefficient 0.15cc/year, 95% CI 0.02 to 0.28cc/year) as was baseline lesion volume (0.6cc/year, 95% CI 0.13 to 1.06 cc/year). Both hypertension (OR 1.72, 95% CI 1.19 to 2.46) and current smoking (OR 1.48, 95% CI 1.02 to 2.16) were associated with WMH growth. Sample sizes for a clinical trial varied greatly with patient population selection and baseline lesion volume; estimates are provided.ConclusionsWMH progression varies markedly according to the characteristics of the population being studied and this will have a major impact on sample sizes required in a clinical trial. Our sample size estimates provide data for planning clinical trials using WMH as an outcome measure.PROSPERO registration numberCRD42020191781.

Published
2021
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37. sj-pdf-1-jcb-10.1177_0271678X231173587 - Supplemental material for Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife

Author

Dounavi, Maria-Eleni, Mak, Elijah, Swann, Peter, Low, Audrey, Muniz-Terrera, Graciela, McKeever, Anna, Pope, Marianna, Williams, Guy B, Wells, Katie, Lawlor, Brian, Naci, Lorina, Malhotra, Paresh, Mackay, Clare, Koychev, Ivan, Ritchie, Karen, Su, Li, Ritchie, Craig W, and O’Brien, John T

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231173587 for Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife by Maria-Eleni Dounavi, Elijah Mak, Peter Swann, Audrey Low, Graciela Muniz-Terrera, Anna McKeever, Marianna Pope, Guy B Williams, Katie Wells, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Karen Ritchie, Li Su, Craig W Ritchie and John T O’Brien: on behalf of the SVDs@target consortium in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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38. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Izadi, Zara, primary, Gianfrancesco, Milena A, additional, Schmajuk, Gabriela, additional, Jacobsohn, Lindsay, additional, Katz, Patricia, additional, Rush, Stephanie, additional, Ja, Clairissa, additional, Taylor, Tiffany, additional, Shidara, Kie, additional, Danila, Maria I, additional, Wysham, Katherine D, additional, Strangfeld, Anja, additional, Mateus, Elsa F, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson-Tovey, Saskia, additional, Kearsley-Fleet, Lianne, additional, Schaefer, Martin, additional, Al-Emadi, Samar, additional, Sparks, Jeffrey A, additional, Hsu, Tiffany Y-T, additional, Patel, Naomi J, additional, Wise, Leanna, additional, Gilbert, Emily, additional, Duarte-García, Alí, additional, Valenzuela-Almada, Maria O, additional, Ugarte-Gil, Manuel F, additional, Ljung, Lotta, additional, Scirè, Carlo A, additional, Carrara, Greta, additional, Hachulla, Eric, additional, Richez, Christophe, additional, Cacoub, Patrice, additional, Thomas, Thierry, additional, Santos, Maria J, additional, Bernardes, Miguel, additional, Hasseli, Rebecca, additional, Regierer, Anne, additional, Schulze-Koops, Hendrik, additional, Müller-Ladner, Ulf, additional, Pons-Estel, Guillermo, additional, Tanten, Romina, additional, Nieto, Romina E, additional, Pisoni, Cecilia N, additional, Tissera, Yohana S, additional, Xavier, Ricardo, additional, Lopes Marques, Claudia D, additional, Pileggi, Gecilmara C S, additional, Robinson, Philip C, additional, Machado, Pedro M, additional, Sirotich, Emily, additional, Liew, Jean W, additional, Hausmann, Jonathan S, additional, Sufka, Paul, additional, Grainger, Rebecca, additional, Bhana, Suleman, additional, Gore-Massy, Monique, additional, Wallace, Zachary S, additional, Yazdany, Jinoos, additional, Dahou, Brahim, additional, Gómez, Gimena, additional, Roberts, Karen, additional, Baez, Roberto M, additional, Castro Coello, Vanessa V, additional, Haye Salinas, María J, additional, Maldonado, Federico N, additional, Reyes, Alvaro A, additional, Alle, Gelsomina, additional, Maldonado Ficco, Hernán, additional, Nieto, Romina, additional, Gobbi, Carla, additional, Tissera, Yohana, additional, Pisoni, Cecilia, additional, Paula, Alba, additional, Albiero, Juan A, additional, Schmid, Maria M, additional, Cosatti, Micaela, additional, Gamba, Maria J, additional, Leandro, Carlevaris, additional, Cusa, María A, additional, German, Noelia, additional, Bellomio, Veronica, additional, Takashima, Lorena, additional, Pera, Mariana, additional, Cogo, Karina, additional, Gálvez Elkin, Maria S, additional, Medina, María A, additional, Savio, Veronica, additional, Rojas Tessel, Romina, additional, Alamino, Rodolfo P, additional, Werner, Marina L, additional, Ornella, Sofía, additional, Casalla, Luciana, additional, de la Vega, Maria, additional, Severina, María, additional, García, Mercedes, additional, Gonzalez Lucero, Luciana, additional, Romeo, Cecilia, additional, Moyano, Sebastián, additional, Barbich, Tatiana, additional, Bertoli, Ana, additional, Baños, Andrea, additional, Petruzzelli, Sandra, additional, Matellan, Carla, additional, Conti, Silvana, additional, Lazaro, Maria A, additional, Rodriguez Gil, Gustavo F, additional, Risueño, Fabian, additional, Quaglia, Maria I, additional, Scafati, Julia, additional, Cuchiaro, Natalia L, additional, Rebak, Jonathan E, additional, Pineda, Susana I, additional, Calvo, María E, additional, Picco, Eugenia, additional, Yanzi, Josefina G, additional, Maid, Pablo, additional, Guaglianone, Debora, additional, Morbiducci, Julieta S, additional, Porta, Sabrina, additional, Herscovich, Natalia, additional, Velasco Zamora, José L, additional, Kisluk, Boris, additional, Castaños Menescardi, Maria S, additional, Gallo, Rosana, additional, Martire, María V, additional, Maldini, Carla, additional, Goizueta, Cecilia, additional, de la Vega Fernandez, Sabrina S, additional, Aeschlimann, Carolina, additional, Subils, Gisela, additional, Rath, Eva, additional, Piette, Yves, additional, Devinck, Mieke, additional, Maeyaert, Bea, additional, Machado Ribeiro, Francinne, additional, Euzebio Ribeiro, Sandra L, additional, Pinheiro, Marcelo, additional, Ibáñez, Sebastián, additional, Chassin Trubert, Anne-Marie, additional, Dong, Lingli, additional, Cajas, Lui, additional, Barešić, Marko, additional, Anić, Branimir, additional, Ćulo, Melanie-Ivana, additional, Pavelić, Tea A, additional, Stranski, Kristina K, additional, Karanovic, Boris, additional, Vencovsky, Jiri, additional, Píchová, Marta, additional, Filkova, Maria, additional, Hamoud, Hesham, additional, Vassilopoulos, Dimitrios, additional, Guzman Melgar, Gabriela M, additional, So, Ho, additional, Király, Márta, additional, Vojdanian, Mahdi, additional, Balbir Gurman, Alexandra, additional, Abutiban, Fatemah, additional, Zepa, Julija, additional, Bulina, Inita, additional, Bukauskiene, Loreta, additional, Zazueta Montiel, Beatriz E, additional, Castillo Ortiz, Angel A, additional, Zamora Tehozol, Erick, additional, Vega Morales, David, additional, Cervántes Rosete, Diana, additional, Martín Nares, Eduardo, additional, Rodriguez Reyna, Tatiana S, additional, Rull Gabayet, Marina, additional, Alpízar Rodríguez, Deshiré, additional, Irazoque, Fedra, additional, Jimenez, Xochitl, additional, Geurts van Bon, Lenny, additional, Zijlstra, Theo, additional, Hoekstra, Monique, additional, Al Adhoubi, Nasra, additional, Salim, Babur, additional, Giraldo, Enrique, additional, Salinas, Ariel, additional, Ugarte Gil, Manuel, additional, Nowakowski, Jarosław, additional, Conway, Richard, additional, Flood, Rachael, additional, McCarthy, Geraldine, additional, Felea, Ioana, additional, Filipescu, Ileana, additional, Rednic, Simona, additional, Groseanu, Laura, additional, Tamas, Maria M, additional, Mlynarikova, Vanda, additional, Skamlova, Martina, additional, Zlnay, Martin, additional, Mičeková, Dagmar, additional, Capova, Lubica, additional, Macejova, Zelmira, additional, Šteňová, Emőke, additional, Raffayova, Helena, additional, Belakova, Gabriela, additional, Strakova, Eva, additional, Senčarová, Marieta, additional, Žlnayová, Soňa, additional, Sabová, Anna, additional, Spisakova, Daniela, additional, Oetterová, Mária, additional, Lukacova, Olga, additional, Bakosova, Martina, additional, Hocevar, Alojzija, additional, de la Torre Rubio, Natalia, additional, Alegre Sancho, Juan J, additional, Corteguera Coro, Montserrat, additional, Cobeta Garcia, Juan C, additional, Torres Martin, Maria C, additional, Campos, Jose, additional, Gomez Puerta, Jose A, additional, Yardimci, Gozd K, additional, Akar, Servet, additional, Icacan, Ozan C, additional, ÇELİK, Selda, additional, Vasylets, Viktoriia, additional, Yeoh, Su-Ann, additional, Vandevelde, Claire, additional, Dunt, Sasha, additional, Leeder, Jane, additional, Macphie, Elizabeth, additional, Salerno, Rosaria, additional, Graver, Christine, additional, Williams, Katie, additional, O'Reilly, Sheila, additional, Devine, Kirsty, additional, Tyler, Jennifer, additional, Warner, Elizabeth, additional, Pilcher, James, additional, Patel, Samir, additional, Nikiphorou, Elena, additional, Chadwick, Laura, additional, Jones, Caroline M, additional, Harrison, Beverley, additional, Thornton, Lucy, additional, O'Kane, Diana, additional, Fusi, Lucia, additional, Low, Audrey, additional, Horton, Sarah, additional, Jatwani, Shraddha, additional, Baig, Sara, additional, Bajwa, Hammad, additional, Berglund, Vernon, additional, Dahle, Angela, additional, Dorman, Walter, additional, Hargrove, Jody, additional, Hilton, Maren, additional, Lebedoff, Nicholas, additional, Leonard, Susan, additional, Morgan, Jennifer, additional, Pfeifer, Emily, additional, Skemp, Archibald, additional, Wilson, Jeffrey, additional, Wolff, Anne, additional, Cepeda, Eduardo, additional, Todd, Derrick, additional, Hare, Denise, additional, Calabrese, Cassandra, additional, Adams, Christopher, additional, Khosroshahi, Arezou, additional, Kilian, Adam, additional, White, Douglas, additional, Winter, Melanie, additional, Fields, Theodore, additional, Siegel, Caroline, additional, Daver, Nicole, additional, Harvey, Melissa, additional, Kramer, Neil, additional, Lamore, Concetta, additional, Hogarty, Suneya, additional, Yeter, Karen, additional, Siddique, Faizah, additional, Ban, Byung, additional, Tanner, Tamar, additional, Ruderman, Eric, additional, Davis, William, additional, Quinet, Robert, additional, Scopelitis, Evangeline, additional, Toribio, Karen, additional, Webb Detiege, Tameka, additional, Zakem, Jerald, additional, Abbass, Khurram, additional, Kepecs, Gilbert, additional, Miranda, Lilliam, additional, Guma, Michael, additional, Haikal, Ammar, additional, Mody, Sushama, additional, Mueller, Daric, additional, Jayatilleke, Arundathi, additional, Zell, JoAnn, additional, Bays, Alison, additional, Dao, Kathryn, additional, Ezzati, Fatemeh, additional, Parks, Deborah, additional, Karp, David, additional, and Quiceno, Guillermo, additional

Published
2022
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39. Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Author

Mercer, Louise K, Galloway, James B, Lunt, Mark, Davies, Rebecca, Low, Audrey L S, Dixon, William G, Watson, Kath D, Symmons, Deborah P M, Hyrich, Kimme L, Maiden, Nicola, Price, Tom, Hopkinson, Neil, OʼReilly, Sheila, Hordon, Lesley, Griffiths, Ian, Porter, Duncan, Madhok, R, Hassell, Andy, Cooper, R G, Choy, Ernest, Walsh, David, Emery, Professor Paul, Knight, Susan, Bruce, Ian, Taggart, Allister, Scott, Professor David, Thompson, Paul, McCrae, Fiona, Goodfellow, Rhian, Kitas, Professor George, Jubb, Ronald, Abernethy, Rikki, Green, Sandra, Sanders, Paul, Coulson, Amanda, Harrison, Bev, Bukhari, Marwan, and Klimiuk, Peter

Published
2017
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42. Additional file 1 of Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study

Author

Low, Audrey, Prats-Sedano, Maria A., McKiernan, Elizabeth, Carter, Stephen F., Stefaniak, James D., Nannoni, Stefania, Su, Li, Dounavi, Maria-Eleni, Muniz-Terrera, Graciela, Ritchie, Karen, Lawlor, Brian, Naci, Lorina, Malhotra, Paresh, Mackay, Clare, Koychev, Ivan, Ritchie, Craig W., Markus, Hugh S., and O’Brien, John T.

Abstract

Additional file 1: Supplementary Table 1. Scoring of global cerebral small vessel disease (SVD) burden, hypertensive arteriopathy, and cerebral amyloid angiopathy scores. Supplementary Table 2. Factor loadings from confirmatory factor analysis of measurement models.

Published
2022
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43. CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study

Author

Low, Audrey, primary, Prats-Sedano, Maria A, additional, Stefaniak, James D, additional, McKiernan, Elizabeth Frances, additional, Carter, Stephen F, additional, Douvani, Maria-Eleni, additional, Mak, Elijah, additional, Su, Li, additional, Stupart, Olivia, additional, Muniz, Graciela, additional, Ritchie, Karen, additional, Ritchie, Craig W, additional, Markus, Hugh S, additional, and O'Brien, John Tiernan, additional

Published
2022
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45. Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice

Author

Casu, Carla, primary, Liu, Alison, additional, De Rosa, Gianluca, additional, Low, Audrey, additional, Suzuki, Aae, additional, Sinha, Sayantani, additional, Ginzburg, Yelena Z., additional, Abrams, Charles, additional, Aghajan, Mariam, additional, Guo, Shuling, additional, and Rivella, Stefano, additional

Published
2021
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46. The effects of age and hypertension on cerebral small‐vessel disease differ between men and women at midlife: The PREVENT Dementia study

Author

Low, Audrey, primary, Prats‐Sedano, Maria, additional, Stefaniak, James D, additional, Dounavi, Maria‐Eleni, additional, McKiernan, Elizabeth, additional, Carter, Stephen F, additional, Mak, Elijah, additional, Su, Li, additional, Muñiz‐Terrera, Graciela, additional, Ritchie, Karen, additional, Ritchie, Craig W, additional, Markus, Hugh S, additional, and O'Brien, John T, additional

Published
2021
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47. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Sattui, Sebastian E, primary, Conway, Richard, additional, Putman, Michael S, additional, Seet, Andrea M, additional, Gianfrancesco, Milena A, additional, Beins, Kaley, additional, Hill, Catherine, additional, Liew, David, additional, Mackie, Sarah L, additional, Mehta, Puja, additional, Neill, Lorna, additional, Gomez, Gimena, additional, Salinas, Maria Isabel Haye, additional, Maldonado, Federico Nicolas, additional, Mariz, Henrique Ataide, additional, de Sousa Studart, Samia Araujo, additional, Araujo, Nafice Costa, additional, Knight, Ann, additional, Rozza, Davide, additional, Quartuccio, Luca, additional, Samson, Maxime, additional, Bally, Stéphane, additional, Maria, Alexandre TJ, additional, Chazerain, Pascal, additional, Hasseli, Rebecca, additional, Müller-Ladner, Ulf, additional, Hoyer, Bimba F, additional, Voll, Reinhard, additional, Torres, Rita Pinheiro, additional, Luis, Mariana, additional, Ribeirio, Sandra Lucia Euzebio, additional, Al-Emadi, Samar, additional, Sparks, Jeffrey A, additional, Hsu, Tiffany Y-T, additional, D’Silva, Kristin M, additional, Patel, Naomi J, additional, Wise, Leanna, additional, Gilbert, Emily, additional, Almada, Maria Valenzuela, additional, Duarte-García, Alí, additional, Ugarte-Gil, Manuel, additional, Jacobsohn, Lindsay, additional, Izadi, Zara, additional, Strangfeld, Anja, additional, Mateus, Elsa F, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson-Tovey, Saskia, additional, Kearsley-Fleet, Lianne, additional, Schaefer, Martin, additional, Sirotich, Emily, additional, Hausmann, Jonathan S, additional, Sufka, Paul, additional, Bhana, Suleman, additional, Liew, Jean W, additional, Grainger, Rebecca, additional, Machado, Pedro M, additional, Wallace, Zachary S, additional, Yazdany, Jinoos, additional, Robinson, Philip C, additional, Dahou, Brahim, additional, Rath, Eva, additional, Piette, Yves, additional, Devinck, Mieke, additional, Maeyaert, Bea, additional, Machado Ribeiro, Francinne, additional, Euzebio Ribeiro, Sandra Lucia, additional, Pinheiro, Marcelo, additional, Quintana, Rosana, additional, Gómez, Gimena, additional, Roberts, Karen, additional, Baez, Roberto Miguel, additional, Castro Coello, Vanessa, additional, Haye Salinas, María J., additional, Reyes Torres, Alvaro Andres, additional, Alle, Gelsomina, additional, Tanten, Romina, additional, Maldonado Ficco, Hernán, additional, Nieto, Romina, additional, Gobbi, Carla, additional, Tissera, Yohana, additional, Pisoni, Cecilia, additional, Paula, Alba, additional, Albiero, Juan Alejandro, additional, Schmid, Maria Marcela, additional, Cosatti, Micaela, additional, Gamba, Maria Julieta, additional, Leandro, Carlevaris, additional, Cusa, María Alejandra, additional, German, Noelia, additional, Bellomio, Veronica, additional, Takashima, Lorena, additional, Pera, Mariana, additional, Cogo, Karina, additional, Gálvez Elkin, Maria Soledad, additional, Medina, María Alejandra, additional, Savio, Veronica, additional, Rojas Tessel, Ivana Romina, additional, Perez Alamino, Rodolfo, additional, Werner, Marina Laura, additional, Ornella, Sofía, additional, Casalla, Luciana, additional, de la Vega, Maria, additional, Severina, María, additional, García, Mercedes, additional, Gonzalez Lucero, Luciana, additional, Romeo, Cecilia, additional, Moyano, Sebastián, additional, Barbich, Tatiana, additional, Bertoli, Ana, additional, Baños, Andrea, additional, Petruzzelli, Sandra, additional, Matellan, Carla, additional, Conti, Silvana, additional, Lazaro, Ma. Alicia, additional, Rodriguez Gil, Gustavo Fabián, additional, Risueño, Fabian, additional, Quaglia, Maria Isabel, additional, Scafati, Julia, additional, Cuchiaro, Natalia Lili, additional, Rebak, Jonathan Eliseo, additional, Pineda, Susana Isabel, additional, Calvo, María Elena, additional, Picco, Eugenia, additional, Gallino Yanzi, Josefina, additional, Maid, Pablo, additional, Guaglianone, Debora, additional, Morbiducci, Julieta Silvana, additional, Porta, Sabrina, additional, Herscovich, Natalia, additional, Velasco Zamora, José Luis, additional, Kisluk, Boris, additional, Castaños Menescardi, Maria Sol, additional, Gallo, Rosana, additional, Martire, María Victoria, additional, Maldini, Carla, additional, Goizueta, Cecilia, additional, de la Vega Fernandez, Sabrina Solange, additional, Aeschlimann, Carolina, additional, Subils, Gisela, additional, Ibáñez, Sebastián, additional, Chassin-Trubert, Anne-Marie, additional, Dong, Lingli, additional, Cajas, Lui, additional, Barešic, 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Lucia, additional, Low, Audrey, additional, Horton, Sarah, additional, Jatwani, Shraddha, additional, Baig, Sara, additional, Bajwa, Hammad, additional, Berglund, Vernon, additional, Dahle, Angela, additional, Dorman, Walter, additional, Hargrove, Jody, additional, Hilton, Maren, additional, Lebedoff, Nicholas, additional, Leonard, Susan, additional, Morgan, Jennifer, additional, Pfeifer, Emily, additional, Skemp, Archibald, additional, Wilson, Jeffrey, additional, Wolff, Anne, additional, Cepeda, Eduardo, additional, D'Silva, Kristin, additional, Hsu, Tiffany, additional, Patel, Naomi, additional, Sparks, Jeffrey, additional, Todd, Derrick, additional, Wallace, Zachary, additional, Hare, Denise, additional, Calabrese, Cassandra, additional, Adams, Christopher, additional, Khosroshahi, Arezou, additional, Kilian, Adam, additional, White, Douglas, additional, Winter, Melanie, additional, Fields, Theodore, additional, Siegel, Caroline, additional, Daver, Nicole, additional, Harvey, Melissa, additional, Kramer, Neil, additional, Lamore, Concetta, additional, Hogarty, Suneya, additional, Yeter, Karen, additional, Siddique, Faizah, additional, Ban, Byung, additional, Tanner, Tamar, additional, Ruderman, Eric, additional, Davis, William, additional, Quinet, Robert, additional, Scopelitis, Evangeline, additional, Toribio Toribio, Karen, additional, Webb-Detiege, Tameka, additional, Zakem, Jerald, additional, Abbass, Khurram, additional, Kepecs, Gilbert, additional, Miranda, Lilliam, additional, Guma, Michael, additional, Haikal, Ammar, additional, Mody, Sushama, additional, Mueller, Daric, additional, Jayatilleke, Arundathi, additional, Zell, JoAnn, additional, Bays, Alison, additional, Dao, Kathryn, additional, Fatemeh, Ezzati, additional, Parks, Deborah, additional, Karp, David, additional, and Quiceno, Guillermo, additional

Published
2021
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49. Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Author

Mercer, Louise K, Lunt, Mark, Low, Audrey L S, Dixon, William G, Watson, Kath D, Symmons, Deborah P M, Hyrich, Kimme L, Maiden, Nicola, Price, Tom, Hopkinson, Neil, OʼReilly, Sheila, Hordon, Lesley, Griffiths, Ian, Porter, Duncan, Madhok, R, Hassell, Andy, Cooper, R G, Choy, Ernest, Walsh, David, Emery, Paul, Knight, Susan, Bruce, Ian, Taggart, Allister, Scott, David, Thompson, Paul, McCrae, Fiona, Goodfellow, Rhian, Kitas, George, Jubb, Ronald, Abernethy, Rikki, Green, Sandra, Sanders, Paul, Coulson, Amanda, Harrison, Bev, Bukhari, Marwan, and Klimiuk, Peter

Published
2015
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50. Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Author

Anderson, Brooke A, primary, Freestone, Graeme C, additional, Low, Audrey, additional, De-Hoyos, Cheryl L, additional, III, William J Drury, additional, Østergaard, Michael E, additional, Migawa, Michael T, additional, Fazio, Michael, additional, Wan, W Brad, additional, Berdeja, Andres, additional, Scandalis, Eli, additional, Burel, Sebastien A, additional, Vickers, Timothy A, additional, Crooke, Stanley T, additional, Swayze, Eric E, additional, Liang, Xuehai, additional, and Seth, Punit P, additional

Published
2021
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