31 results on '"Lowe CH"'
Search Results
2. New enzymen sensors for morphine and codeine based on morphine dehydrogenase and laccase
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Bauer, Christian G., Kühn, A., Gajovic, Nenad, Skorobogatko, O. V., Holt, P. J., Bruce, N. C., Makower, Alexander, Lowe, Ch. R., and Scheller, Frieder W.
- Subjects
Institut für Biochemie und Biologie - Published
- 1999
3. Estimation of future nutrient enrichment in Europes regional seas.
- Author
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Gilbert, A., Artioli, Y., Daunys, D., Friedrich, Jana, Humborg, Ch., Lowe, Ch., McQuatters-Gallop, A., Mee, L. D., Olenin, S., Palmeri, L., Gilbert, A., Artioli, Y., Daunys, D., Friedrich, Jana, Humborg, Ch., Lowe, Ch., McQuatters-Gallop, A., Mee, L. D., Olenin, S., and Palmeri, L.
- Published
- 2007
4. Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics
- Author
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Burren Oliver S, Healy Barry C, Lam Alex C, Schuilenburg Helen, Dolman Geoffrey E, Everett Vincent H, Laneri Davide, Nutland Sarah, Rance Helen E, Payne Felicity, Smyth Deborah, Lowe Chris, Barratt Bryan J, Twells Rebecca CJ, Rainbow Daniel B, Wicker Linda S, Todd John A, Walker Neil M, and Smink Luc J
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type 1 diabetes ,complex disease ,genome informatics ,data management ,genetics ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract The genetic dissection of complex disease remains a significant challenge. Sample-tracking and the recording, processing and storage of high-throughput laboratory data with public domain data, require integration of databases, genome informatics and genetic analyses in an easily updated and scaleable format. To find genes involved in multifactorial diseases such as type 1 diabetes (T1D), chromosome regions are defined based on functional candidate gene content, linkage information from humans and animal model mapping information. For each region, genomic information is extracted from Ensembl, converted and loaded into ACeDB for manual gene annotation. Homology information is examined using ACeDB tools and the gene structure verified. Manually curated genes are extracted from ACeDB and read into the feature database, which holds relevant local genomic feature data and an audit trail of laboratory investigations. Public domain information, manually curated genes, polymorphisms, primers, linkage and association analyses, with links to our genotyping database, are shown in Gbrowse. This system scales to include genetic, statistical, quality control (QC) and biological data such as expression analyses of RNA or protein, all linked from a genomics integrative display. Our system is applicable to any genetic study of complex disease, of either large or small scale.
- Published
- 2004
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5. The transcriptome of the novel dinoflagellate Oxyrrhis marina (Alveolata: Dinophyceae): response to salinity examined by 454 sequencing
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Montagnes David JS, Martin Laura E, Samatar Najma, Mello Luciane V, Lowe Chris D, and Watts Phillip C
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Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background The heterotrophic dinoflagellate Oxyrrhis marina is increasingly studied in experimental, ecological and evolutionary contexts. Its basal phylogenetic position within the dinoflagellates make O. marina useful for understanding the origin of numerous unusual features of the dinoflagellate lineage; its broad distribution has lent O. marina to the study of protist biogeography; and nutritive flexibility and eurytopy have made it a common lab rat for the investigation of physiological responses of marine heterotrophic flagellates. Nevertheless, genome-scale resources for O. marina are scarce. Here we present a 454-based transcriptome survey for this organism. In addition, we assess sequence read abundance, as a proxy for gene expression, in response to salinity, an environmental factor potentially important in determining O. marina spatial distributions. Results Sequencing generated ~57 Mbp of data which assembled into 7, 398 contigs. Approximately 24% of contigs were nominally identified by BLAST. A further clustering of contigs (at ≥ 90% identity) revealed 164 transcript variant clusters, the largest of which (Phosphoribosylaminoimidazole-succinocarboxamide synthase) was composed of 28 variants displaying predominately synonymous variation. In a genomic context, a sample of 5 different genes were demonstrated to occur as tandem repeats, separated by short (~200-340 bp) inter-genic regions. For HSP90 several intergenic variants were detected suggesting a potentially complex genomic arrangement. In response to salinity, analysis of 454 read abundance highlighted 9 and 20 genes over or under expressed at 50 PSU, respectively. However, 454 read abundance and subsequent qPCR validation did not correlate well - suggesting that measures of gene expression via ad hoc analysis of sequence read abundance require careful interpretation. Conclusion Here we indicate that tandem gene arrangements and the occurrence of multiple transcribed gene variants are common and indicate potentially complex genomic arrangements in O. marina. Comparison of the reported data set with existing O. marina and other dinoflagellates ESTs indicates little sequence overlap likely as a result of the relatively limited extent of genome scale sequence data currently available for the dinoflagellates. This is one of the first 454-based transcriptome surveys of an ancestral dinoflagellate taxon and will undoubtedly prove useful for future comparative studies aimed at reconstructing the origin of novel features of the dinoflagellates.
- Published
- 2011
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6. Contrasting genetic association of IL2RA with SLE and ANCA – associated vasculitis
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Todd John A, Lowe Christopher E, Clatworthy Menna R, Carr Edward J, Wong Andrew, Vyse Timothy J, Kamesh Lavanya, Watts Richard A, Lyons Paul A, and Smith Kenneth GC
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Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Autoimmune diseases are complex and have genetic and environmental susceptibility factors. The objective was to test the genetic association of systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic antibody (ANCA) – associated systemic vasculitis (AAV) with SNPs in the IL2RA region and to correlate genotype with serum levels of IL-2RA. Methods Using a cohort of over 700 AAV patients, two SLE case-control studies and an SLE trio collection (totalling over 1000 SLE patients), and a TaqMan genotyping approach, we tested 3 SNPs in the IL2RA locus, rs11594656, rs2104286 & rs41295061, each with a prior association with autoimmune disease; rs11594656 and rs41295061 with type 1 diabetes (T1D) and rs2104286 with multiple sclerosis (MS) and T1D. Results We show that SLE is associated with rs11594656 (P = 3.87 × 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D – associated SNP in the IL2RA locus, is not associated with either SLE or AAV. Conclusion We have confirmed a previous suggestion that the IL2RA locus is associated with SLE and showed some evidence of association with AAV. Soluble IL-2RA concentrations correlate with rs11594656 genotype in quiescent disease in both AAV and SLE. Differential association of autoimmune diseases and SNPs within the IL2RA locus suggests that the IL2RA pathway may prove to play differing, as yet undefined, roles in each disease.
- Published
- 2009
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7. Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11
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Barratt Bryan J, Twells Rebecca, Smith Anne, Walker Neil M, Nutland Sarah, Stevens Helen, Burren Oliver, Lam Alex, Godfrey Lisa, Masters Jennifer, Payne Felicity, Lowe Christopher E, Bailey Rebecca, Smyth Deborah, Smink Luc J, Nejentsev Sergey, Wright Charmain, French Lisa, Chen Yuan, Deloukas Panagiotis, Rogers Jane, Dunham Ian, and Todd John A
- Subjects
Genetics ,QH426-470 - Abstract
Abstract Background In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D. Results Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs) and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 – 0.0026), located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively). Conclusion We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region.
- Published
- 2007
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8. Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes
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Smink Luc J, Walker Neil M, Burren Oliver, Lam Alex C, Healy Barry C, Nutland Sarah, Bailey Rebecca, Smyth Deborah J, Cooper Jason D, Lowe Christopher E, Taniguchi Hidenori, Wicker Linda S, and Todd John A
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Genetics ,QH426-470 - Abstract
Abstract Background Type 1 diabetes (T1D) is a common autoimmune disease resulting from T-cell mediated destruction of pancreatic beta cells. Decay accelerating factor (DAF, CD55), a glycosylphosphatidylinositol-anchored membrane protein, is a candidate for autoimmune disease susceptibility based on its role in restricting complement activation and evidence that DAF expression modulates the phenotype of mice models for autoimmune disease. In this study, we adopt a linkage disequilibrium (LD) mapping approach to test for an association between the DAF gene and T1D. Results Initially, we used HapMap II genotype data to examine LD across the DAF region. Additional resequencing was required, identifying 16 novel polymorphisms. Combining both datasets, a LD mapping approach was adopted to test for association with T1D. Seven tag SNPs were selected and genotyped in case-control (3,523 cases and 3,817 controls) and family (725 families) collections. Conclusion We obtained no evidence of association between T1D and the DAF region in two independent collections. In addition, we assessed the impact of using only HapMap II genotypes for the selection of tag SNPs and, based on this study, found that HapMap II genotypes may require additional SNP discovery for comprehensive LD mapping of some genes in common disease.
- Published
- 2006
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9. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
- Author
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Walker Neil M, Nutland Sarah, Lam Alex C, Dahlman Ingrid, Vella Adrian, Hulme John S, Cooper Jason D, Lowe Christopher E, Holland Kieran, Bailey Rebecca, Maier Lisa M, Payne Felicity, Howson Joanna MM, Smyth Deborah J, Twells Rebecca CJ, and Todd John A
- Subjects
Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease development. Some genes have been shown to affect several immune-mediated diseases. Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D. Methods We resequenced and genotyped tag single nucleotide polymorphisms (SNPs) from two genes, CRP and FCER1B, and genotyped 27 disease-associated polymorphisms from thirteen gene regions, namely FCRL3, CFH, SLC9A3R1, PADI4, RUNX1, SPINK5, IL1RN, IL1RA, CARD15, IBD5-locus (including SLC22A4), LAG3, ADAM33 and NFKB1. These genes have been associated previously with susceptibility to a range of immune-mediated diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Graves' disease (GD), psoriasis, psoriatic arthritis (PA), atopy, asthma, Crohn disease and multiple sclerosis (MS). Our T1D collections are divided into three sample subsets, consisting of set 1 families (up to 754 families), set 2 families (up to 743 families), and a case-control collection (ranging from 1,500 to 4,400 cases and 1,500 to 4,600 controls). Each SNP was genotyped in one or more of these subsets. Our study typically had approximately 80% statistical power for a minor allele frequency (MAF) >5% and odds ratios (OR) of 1.5 with the type 1 error rate, α = 0.05. Results We found no evidence of association with T1D at most of the loci studied 0.02
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- 2006
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10. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes
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Lam Alex C, Healy Barry C, Walker Neil M, Hulme John S, Godfrey Lisa, Vella Adrian, Payne Felicity, Cooper Jason D, Lowe Christopher E, Morris Gerard AJ, Lyons Paul A, and Todd John A
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Genetics ,QH426-470 - Abstract
Abstract Background The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initiation and/or pathogenic process of autoimmunity. In the present report, we have adopted a linkage disequilibrium (LD) mapping approach to test for an association between T1D and three regions encompassing 13 interferon alpha (IFNA) genes, interferon omega-1 (IFNW1), interferon beta-1 (IFNB1), interferon gamma (IFNG) and the interferon consensus-sequence binding protein 1 (ICSBP1). Results We identified 238 variants, most, single nucleotide polymorphisms (SNPs), by sequencing IFNA, IFNB1, IFNW1 and ICSBP1, 98 of which where novel when compared to dbSNP build 124. We used polymorphisms identified in the SeattleSNP database for INFG. A set of tag SNPs was selected for each of the interferon and interferon-related genes to test for an association between T1D and this complex gene family. A total of 45 tag SNPs were selected and genotyped in a collection of 472 multiplex families. Conclusion We have developed informative sets of SNPs for the interferon and interferon related genes. No statistical evidence of a major association between T1D and any of the interferon and interferon related genes tested was found.
- Published
- 2006
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11. Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes
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Savage David A, Ionescu-Tîrgovişte Constantin, Guja Cristian, Rønningen Kjersti S, Undlien Dag E, Nutland Sarah, Walker Neil, Chamberlain Giselle, Hunter Kara M, Moule Carolyn, Fraser Heather, Smink Luc J, Hulme John, Lowe Christopher, Pask Rebecca, Cooper Jason D, Payne Felicity, Vella Adrian, Smyth Deborah J, Maier Lisa M, Strachan David P, Peterson Laurence B, Todd John A, Wicker Linda S, and Twells Rebecca C
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Genetics ,QH426-470 - Abstract
Abstract Background One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 diabetes. Linkage and congenic strain analyses have identified several NOD mouse Idd (insulin dependent diabetes) loci, which have been mapped to small chromosome intervals, for which the orthologous regions in the human genome can be identified. Here, we have conducted re-sequencing and association analysis of six orthologous genes identified in NOD Idd loci: NRAMP1/SLC11A1 (orthologous to Nramp1/Slc11a1 in Idd5.2), FRAP1 (orthologous to Frap1 in Idd9.2), 4-1BB/CD137/TNFRSF9 (orthologous to 4-1bb/Cd137/Tnrfrsf9 in Idd9.3), CD101/IGSF2 (orthologous to Cd101/Igsf2 in Idd10), B2M (orthologous to B2m in Idd13) and VAV3 (orthologous to Vav3 in Idd18). Results Re-sequencing of a total of 110 kb of DNA from 32 or 96 type 1 diabetes cases yielded 220 single nucleotide polymorphisms (SNPs). Sixty-five SNPs, including 54 informative tag SNPs, and a microsatellite were selected and genotyped in up to 1,632 type 1 diabetes families and 1,709 cases and 1,829 controls. Conclusion None of the candidate regions showed evidence of association with type 1 diabetes (P values > 0.2), indicating that common variation in these key candidate genes does not play a major role in type 1 diabetes susceptibility in the European ancestry populations studied.
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- 2005
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12. Pediatric bipolar disorder versus severe mood dysregulation: risk for manic episodes on follow-up.
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Stringaris A, Baroni A, Haimm C, Brotman M, Lowe CH, Myers F, Rustgi E, Wheeler W, Kayser R, Towbin K, Leibenluft E, Stringaris, Argyris, Baroni, Argelinda, Haimm, Caroline, Brotman, Melissa, Lowe, Catherine H, Myers, Frances, Rustgi, Eileen, Wheeler, Wanda, and Kayser, Reilly
- Abstract
Objective: An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD).Method: Patients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes.Results: Only one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72).Conclusions: These data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes. [ABSTRACT FROM AUTHOR]- Published
- 2010
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13. Clinical correlates of episodicity in juvenile mania.
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Bhangoo RK, Dell ML, Towbin K, Myers FS, Lowe CH, Pine DS, and Leibenluft E
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- Adolescent, Age of Onset, Attention Deficit Disorder with Hyperactivity complications, Attention Deficit Disorder with Hyperactivity psychology, Attention Deficit and Disruptive Behavior Disorders complications, Attention Deficit and Disruptive Behavior Disorders psychology, Bipolar Disorder drug therapy, Bipolar Disorder epidemiology, Child, Child Behavior Disorders epidemiology, Child Behavior Disorders psychology, Depressive Disorder complications, Depressive Disorder psychology, Female, Hospitalization, Humans, Interview, Psychological, Longitudinal Studies, Male, Parents, Psychiatric Status Rating Scales, Psychotic Disorders complications, Psychotic Disorders psychology, Psychotropic Drugs therapeutic use, Suicide, Attempted, Bipolar Disorder psychology
- Abstract
Objective: Researchers debate whether the diagnostic criteria for mania should differ between children and adults. Specifically, although the Diagnostic and Statistical Manual of Mental Disorders (fourth edition; DSM-IV) requires episodic mood changes, children commonly are diagnosed as manic on the basis of chronic irritability. In this preliminary study, children carrying a diagnosis of bipolar disorder (BPD) in the community were classified as having either episodic or chronic symptoms. We hypothesized that the episodic group would be more likely to have a history of psychosis and a parental history of BPD, whereas the chronic group would be more likely to have conduct disorder., Methods: Parents of children carrying the BPD diagnosis were interviewed on the telephone to obtain psychiatric and family histories. Children were considered episodic (n = 34) if they had a history of one or more DSM-IV manic/hypomanic episodes meeting full duration criteria and chronic (n = 53) if they had no discernable episodes., Results: The episodic group was more likely to have had psychosis, parental history of BPD, and to have experienced each manic symptom except for irritability and psychomotor agitation. Children in the episodic group were also more likely to have had a depressive episode meeting full DSM-IV criteria and were more likely to have made a suicide attempt. Children in the chronic group were not more likely to meet criteria for conduct disorder but were more likely to exhibit violence toward others., Conclusions: These preliminary data indicate that, among children being treated for BPD in the community, those with discrete episodes of mania may be more likely to have a lifetime history of psychosis and a parental history of BPD. The latter hypothesis should be tested in a sample where relatives are interviewed directly.
- Published
- 2003
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14. Medication use in children and adolescents treated in the community for bipolar disorder.
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Bhangoo RK, Lowe CH, Myers FS, Treland J, Curran J, Towbin KE, and Leibenluft E
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- Adolescent, Anticonvulsants therapeutic use, Antimanic Agents adverse effects, Bipolar Disorder epidemiology, Bipolar Disorder psychology, Child, Data Collection, Drug Therapy, Combination, Female, Humans, Male, Selective Serotonin Reuptake Inhibitors adverse effects, United States epidemiology, Antimanic Agents therapeutic use, Bipolar Disorder drug therapy, Selective Serotonin Reuptake Inhibitors therapeutic use
- Abstract
We assessed the use of mood stabilizers, stimulants, antipsychotic medication, and selective serotonin reuptake inhibitors in children being treated in the community for bipolar disorder (BPD). One hundred eleven patients were screened via parent phone interview for possible inclusion in a phenomenological study of BPD. Data were obtained on the patients' medication trials and side effects. The results of the study indicated that children and adolescents who carry a diagnosis of BPD are treated with a mean of 3.40 +/- 1.48 medications and have had a mean of 6.32 +/- 3.67 trials of psychotropic medication in the past. Ninety-eight percent have had a trial of a mood stabilizer or anticonvulsant, with the most common being valproate (79%), lithium (51%), and gabapentin (29%).
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- 2003
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15. Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder.
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Turner EH, Schwartz PJ, Lowe CH, Nawab SS, Feldman-Naim S, Drake CL, Myers FS, Barnett RL, and Rosenthal NE
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- Adult, Antidepressive Agents adverse effects, Combined Modality Therapy, Cross-Over Studies, Depressive Disorder, Major diagnosis, Depressive Disorder, Major psychology, Dopamine Agonists administration & dosage, Dopamine Agonists adverse effects, Double-Blind Method, Down-Regulation drug effects, Female, Humans, Male, Metergoline adverse effects, Middle Aged, Phototherapy, Receptors, Serotonin drug effects, Seasonal Affective Disorder diagnosis, Seasonal Affective Disorder psychology, Serotonin Antagonists adverse effects, Antidepressive Agents therapeutic use, Depressive Disorder, Major drug therapy, Metergoline administration & dosage, Seasonal Affective Disorder drug therapy, Serotonin Antagonists administration & dosage
- Abstract
A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the opposite effect. They decided to follow up on this finding with this formal study. The study followed a double-blind, randomized cross-over design. Sixteen untreated, depressed patients with SAD received single oral doses of metergoline 8 mg and of placebo, spaced 1 week apart. Fourteen patients were restudied after 2 weeks of light treatment. Depression ratings using the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version were performed at baseline and at 3 and 6 days after each intervention. These data were analyzed by baseline-corrected repeated measures with analysis of variance. In the off-lights condition, severity of depression was diminished after metergoline compared with placebo administration (p = 0.001). Patient daily self-ratings suggested that the peak effect occurred 2 to 4 days after study drug administration. In contrast, after 2 weeks of treatment with bright artificial light, metergoline did not demonstrate a significant effect on mood. These data suggest that single doses of metergoline may have antidepressant effects that last several days. Possible mechanisms include 5-hydroxytryptamine(2) receptor downregulation and dopamine agonism.
- Published
- 2002
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16. Treatment of rapidly cycling bipolar patient by using extended bed rest and darkness to stabilize the timing and duration of sleep.
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Wehr TA, Turner EH, Shimada JM, Lowe CH, Barker C, and Leibenluft E
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- Bipolar Disorder diagnosis, Bipolar Disorder psychology, Follow-Up Studies, Humans, Male, Middle Aged, Polysomnography, Signal Processing, Computer-Assisted, Sleep Initiation and Maintenance Disorders diagnosis, Sleep Initiation and Maintenance Disorders psychology, Bed Rest, Bipolar Disorder therapy, Circadian Rhythm, Darkness, Sleep Initiation and Maintenance Disorders therapy
- Abstract
Background: The modern practice of using artificial light to extend waking activities into the nighttime hours might be expected to precipitate or exacerbate bipolar illness, because it has been shown that modifying the timing and duration of sleep can induce mania in susceptible individuals. With this possibility in mind, we treated a patient with rapidly cycling bipolar illness by creating an environment that was likely to increase and to stabilize the number of hours that he slept each night., Methods: We asked the patient to remain at bed rest in the dark for 14 hours each night (later this was gradually reduced to 10 hours). Over a period of several years, his clinical state was assessed with twice-daily self-ratings, once-weekly observer ratings, and continuous wrist motor activity recordings. Times of sleeping and waking were recorded with sleep logs, polygraphic recordings, and computer-based event recordings., Results: The patient cycled rapidly between depression and mania and experienced marked fluctuations in the timing and duration of sleep when he slept according to his usual routine, but his sleep and mood stabilized when he adhered to a regimen of long nightly periods of enforced bed rest in the dark., Conclusions: Fostering sleep and stabilizing its timing by scheduling regular nightly periods of enforced bed rest in the dark may help to prevent mania and rapid cycling in bipolar patients.
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- 1998
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17. Case series: pediatric seasonal affective disorder. A follow-up report.
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Giedd JN, Swedo SE, Lowe CH, and Rosenthal NE
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- Adolescent, Child, Comorbidity, Disease Progression, Female, Follow-Up Studies, Humans, Male, Phototherapy, Seasonal Affective Disorder physiopathology, Seasonal Affective Disorder therapy
- Abstract
Six subjects who as children had received a diagnosis of seasonal affective disorder consented to participate in a 7-year follow-up study. Structured and semistructured interviews were conducted to assess the course of illness, response to treatment, and current clinical state. Seasonal patterns of symptoms and response to light therapy remained relatively stable over a 7-year period. Two subjects were using adjunctive fluoxetine. Seasonal affective disorder can occur in children and adolescents, responds to light therapy, and should be considered in the differential diagnosis of pediatric affective symptoms or cyclic school performance.
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- 1998
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18. Validation of the hypomania interview guide-seasonal affective disorder (HIGH-SAD) version in patients with rapid cycling bipolar disorder.
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Feldman-Naim S, Lowe CH, Myers FS, Turner EH, Weinstock LM, and Leibenluft E
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- Adult, Bipolar Disorder psychology, Female, Humans, Male, Reproducibility of Results, Seasonal Affective Disorder psychology, Severity of Illness Index, Bipolar Disorder diagnosis, Psychiatric Status Rating Scales, Seasonal Affective Disorder diagnosis
- Abstract
We validated the Hypomania Interview Guide-Seasonal Affective Disorder version (HIGH-SAD) in patients with rapid cycling bipolar disorder (RCBD). Fourteen outpatients were rated on six separate occasions (total = 84 visits). On each visit the patients were rated with the HIGH-SAD and the Young Mania Rating Scale (YMRS) in a counterbalanced order. Clinical assessment was completed at the end of the visit by the treating psychiatrist. Patients were assessed as hypomanic/manic on 22 of the visits. Pearson correlation coefficient between the YMRS total scores and the HIGH-SAD total scores for those 22 visits in which patients were hypomanic/manic was r = 0.629 (P < 0.05) and for all visits was r = 0.769 (P < 0.0001). Analysis with only one rating per patient yielded a Pearson correlation coefficient of r = 0.792 (P < 0.0004). We found that the HIGH-SAD was a valid scale for the measurement of hypomania in patients with RCBD. However, the scale does not differentiate hypomania from mania in this group of patients.
- Published
- 1998
19. Influence of formulation on ketoconazole pharmacokinetics in man: comparison of standard tablet versus capsule containing citric acid.
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Daneshmend TK, Mason AR, Lowe CH, Warnock DW, and Johnson EM
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- Capsules, Citrates administration & dosage, Citric Acid, Ketoconazole metabolism, Tablets, Ketoconazole administration & dosage
- Published
- 1986
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20. Variation in the circumtesticular Leydig cell tunic of teiid lizards (Cnemidophorus and Ameiva).
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Lowe CH and Goldberg SR
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- Animals, Male, Reptiles, Testis anatomy & histology
- Published
- 1966
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21. Karyotype evolution and speciation in lizards (genus Sceloporus) during evolution of the North American desert.
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Lowe CH, Cole CJ, and Patton JL
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- Animals, Arizona, Karyotyping, Mexico, New Mexico, Utah, Biological Evolution, Cytogenetics, Lizards
- Published
- 1967
22. The Saguaro: A Population in Relation to Environment.
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Niering WA, Whittaker RH, and Lowe CH
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- 1963
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23. Natural free-running period in vertebrate animal populations.
- Author
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Lowe CH, Hinds DS, Lardner PJ, and Justice KE
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- Animals, Behavior, Animal, Circadian Rhythm, Reptiles physiology, Rodentia physiology
- Abstract
Regression analysis (analysis of covariance) is contrasted with the conventional "mean period length" for estimating the length of period of the spontaneous activity frequency (free-running period) in population samples of Gila monsters (Heloderma suspectum) and kangaroo rats (Dipodomys merriami) in the Sonoran Desert. The mean period length in each population does not differ significantly from 24:00 hours (P > .05) and it does not differ significantly (P > .05) between the species studied; the probability that the free-running period a(in constant dark) in natural populations of Gila monsters and kangaroo rats is different from 24:00.0 is less than 1 in 1000 (P < .001). The so-called "mean period length" is of little or no use for precise determination of the period and phase relationships in circadian rhythms; moreover, it is entirely without value for statistical testing of differences either within or between populations.
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- 1967
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24. Sex chromosomes in lizards.
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Cole CJ, Lowe CH, and Wright JW
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- Animals, Cell Division, Female, Karyotyping, Male, Spermatozoa, Reptiles, Sex Chromatin
- Abstract
Karyotypes of many species of the genus Sceloporus support the generalization that there are no morphologically recognizable sex chromosomes in lizards; however, there is a marked sexual dimorphism in the karyotypes of Sceloporus jarrovi and Sceloporus poinsetti. During meiosis in males, whose diploid number of chromosomes is 31, preferential segregation of chromosomes from a trivalent results in heterogamety.
- Published
- 1967
- Full Text
- View/download PDF
25. The treatment of poisonous bites and stings. I. Rattlesnake bite.
- Author
-
LIMBACHER HP and LOWE CH Jr
- Subjects
- Animals, Humans, Bites and Stings, Crotalus, Dental Occlusion, Snake Bites therapy
- Published
- 1959
26. The treatment of poisonous bites and stings. II. Arizona coral snake and Gila monster bite.
- Author
-
LOWE CH Jr and LIMBACHER HP
- Subjects
- Animals, Arizona, Humans, Bites and Stings therapy, Elapidae, Lizards, Snake Bites therapy
- Published
- 1961
27. REPRODUCTIVE CYCLES OF THE IGUANID LIZARDS UROSAURUS ORNATUS AND UTA STANSBURIANA IN SOUTHEASTERN ARIZONA.
- Author
-
ASPLUND KK and LOWE CH
- Subjects
- Animals, Arizona, Male, Anatomy, Epididymis, Histology, Iguanas, Lizards, Ovum, Physiology, Reproduction, Reptiles, Research, Seasons, Seminal Vesicles, Testis
- Published
- 1964
- Full Text
- View/download PDF
28. The reproductive cycle of the western whiptail lizard (Cnemidophorus tigris) in Southern Arizona.
- Author
-
Goldberg SR and Lowe CH
- Subjects
- Animals, Arizona, Epididymis anatomy & histology, Female, Male, Seasons, Seminal Vesicles anatomy & histology, Ovary physiology, Reproduction physiology, Reptiles physiology, Testis anatomy & histology, Testis physiology
- Published
- 1966
- Full Text
- View/download PDF
29. Supercooling in reptiles and other vertebrates.
- Author
-
Lowe CH, Lardner PJ, and Halpern EA
- Subjects
- Animals, Anura, Blood, Body Temperature Regulation, Bufo marinus, Bufonidae, Chemical Phenomena, Chemistry, Physical, Chickens, Cold Temperature, Fishes, Freezing, Humans, Lizards, Rana catesbeiana, Rana pipiens, Rats, Seawater, Snakes, Species Specificity, Turtles, Water, Acclimatization, Body Temperature, Reptiles physiology
- Published
- 1971
- Full Text
- View/download PDF
30. Acclimation of the Critical Thermal Maximum of the Reptile Urosaurus ornatus.
- Author
-
Lowe CH Jr and Vance VJ
- Published
- 1955
- Full Text
- View/download PDF
31. Physiological effects of labial gland secretion from Heloderma (gila monster) upon Heloderma.
- Author
-
BROWN WH and LOWE CH Jr
- Subjects
- Animals, Humans, Lip, Lizards, Salivary Glands, Minor
- Published
- 1954
- Full Text
- View/download PDF
Catalog
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