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Your search keyword '"Lu, Chun-Chi"' showing total 146 results
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146 results on '"Lu, Chun-Chi"'

7. Rituximab induction and reinduction in granulomatosis with polyangiitis and microscopic polyangiitis: A retrospective multicenter study in Taiwan.

Author

Hsieh, Tsu‐Yi, Chen, Ming‐Han, Wu, Chen‐Ching, Hong, Wei‐Jhe, Lu, Cheng‐Hsun, Lu, Chun‐Chi, Lu, Ling‐Ying, Hsieh, Song‐Chou, Tsai, Chang‐Youh, and Wu, Chien‐Sheng

Subjects
MICROSCOPIC polyangiitis, GRANULOMATOSIS with polyangiitis, RITUXIMAB, CHRONIC kidney failure, RENAL replacement therapy
Abstract

Objectives: This study aimed to investigate the clinical outcomes of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) under rituximab induction and reinduction therapy in Taiwan. Methods: We performed a retrospective study in patients with GPA or MPA receiving rituximab therapy from August 2008 to July 2020 in seven medical centers in Taiwan. The clinical characteristics and outcomes of these patients were analyzed. Results: In total, 53 patients (18 with GPA and 35 with MPA) were included. Kidney involvement (82.9% vs. 22.2%, p <.001) and initial creatinine (3.25 ± 2.37 vs. 1.07 ± 0.82, p <.001) were significantly higher in MPA. Within 24 weeks after the first course of rituximab, there were seven deaths (five due to infection and two due to active disease) in patients with MPA (7/35, 20%) compared to 0 in patients with GPA. Of 33 patients receiving rituximab for kidney involvement, 23 survived and were free from renal replacement therapy at 24 weeks. Their chronic kidney disease (CKD) stages improved in 2 but progressed in 7, while 24 had stable CKD stages. Death or end‐stage renal disease (ESRD) was associated with infection and higher initial creatinine. Reinduction therapy for relapse was required in 18 (39.1%) of 46 survivors, which was associated with anti‐proteinase 3 (PR3) positive (odds ratio 3.667, p =.049) and younger age with a cutoff of 49.4 (AUC = 0.679, p =.030, sensitivity = 66.67%, specificity = 75%). Conclusion: Significant mortality occurred after rituximab induction, especially in patients with MPA. In survivors, age younger than 50 and anti‐PR3 positive were associated with the risk of relapse requiring reinduction. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Case report: Vaccine-induced immune thrombotic thrombocytopenia complicated by acute cerebral venous thrombosis and hemorrhage after AstraZeneca vaccines followed by Moderna COVID-19 vaccine booster and surgery

Author

Chen, Quan-Ting, primary, Liu, Yi, additional, Chen, Yeu-Chin, additional, Chou, Chung-Hsing, additional, Lin, Yu-Pang, additional, Lin, Yun-Qian, additional, Tsai, Ming-Chen, additional, Chang, Bo-Kang, additional, Ho, Tsung-Han, additional, Lu, Chun-Chi, additional, and Sung, Yueh-Feng, additional

Published
2022
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27. MRI Contributes to Accurate and Early Diagnosis of Non-Radiographic HLA-B27 Negative Axial Spondyloarthritis

Author

LU, CHUN-CHI, primary, Huang, Guo-Shu, additional, Lee, Tony Szu-Hsien, additional, Chao, En, additional, Chen, Hsiang-Cheng, additional, Yong-Si, Guo, additional, Shi-Jye, Chu, additional, Feng-Cheng, Liu, additional, Kao, San-Yuan, additional, Hou, Tsung-Yun, additional, Chen, Chen-Hung, additional, Chang, Deh-Ming, additional, and Lyu, Sin-Yi, additional

Published
2020
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41. Application of classification criteria of Sjogren syndrome in patients with sicca symptoms: Real-world experience at a medical center.

Author

Chiu, Yu-Hsiang, Szu-Hsien Lee, Tony, Chao, En, Chen, I-Feng, Liu, Feng-Cheng, Chiu, Chung-Hsin, Chen, Hsiang-Cheng, Chang, Deh-Ming, Chu, Shi-Jye, Kuo, San-Yuan, and Lu, Chun-Chi

Subjects
SJOGREN'S syndrome, MEDICAL centers, ELECTRONIC health records, DRY eye syndromes, SALIVARY glands
Abstract

Patients who have symptoms of sicca, such as dry eyes and mouth, may have Sjögren's syndrome (SS). However, the conservative culture makes patients hesitate to undergo an invasive biopsy, which contributes to the difficulty of confirming a diagnosis. We aimed to identify the characteristics of patients with sicca symptoms to develop a better predictive value for each item included in the three different diagnostic criteria for SS and clarify the best diagnostic tools for the local population. This is a single-center retrospective case-control study from January 2016 to December 2017. Patients who underwent sialoscintigraphy because of clinical symptoms of xerostomia and xerophthalmia at one medical center were reviewed via the patients' electronic medical records. Of 515 patients enrolled, the severity of results for sialoscintigraphy and Schirmer's test was correlated with a diagnosis of SS and generated receiver operator characteristic curve. The area under curve (AUC) was 0.603 for positive Schirmer's test, 0.687 for positive anti-Ro/La results, 0.893 for a positive salivary gland biopsy. The AUC was 0.626 and 0.602 for Schirmer's test which is redefined as <10 mm/5 minutes in either eye and according to 2016 the American College of Rheumatology/ European League Against Rheumatism criteria, respectively. Our results indicate the cut-off point for defining a positive test result in the Schirmer's test is worth modified to <10 mm/5 minutes in either eye. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Progressive white matter disease in Sjögren's syndrome.

Author

Cheng, Yung-Wen, Chen, Hsiang-Cheng, Lyu, Sin-Yi, Li, Yao-Feng, and Lu, Chun-Chi

Subjects
DIAGNOSIS of brain diseases, DISEASE progression, PROTEINS, BRAIN, ELECTROENCEPHALOGRAPHY, BIOPSY, MAGNETIC resonance imaging, DIFFERENTIAL diagnosis, WHITE matter (Nerve tissue), SJOGREN'S syndrome, SEIZURES (Medicine)
Abstract

The article presents a case report of a woman in her 60s who was diagnosed with vasculitis, acute disseminated encephalomyelitis, multiple sclerosis (MS), and Sjören's syndrome (SS). Examinations showed an unusual SS case with rapidly progressive white matter disease. Imaging differential diagnoses including immune reconstitution inflammatory syndrome, progressive multifocal leukoencephalopathy (PML), and autoimmune encephalitis were excluded based on the pathology.

Published
2021
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47. COVID limb on FDG‐PET/CT imaging.

Author

Kuo, San‐Yuan, Chu, Chen‐Chih, and Lu, Chun‐Chi

Subjects
COVID-19, RESPIRATORY diseases, COMPUTED tomography, COVID-19 pandemic, MYOSITIS
Abstract

Fluoro-2-deoxy-d-glucose (FDG) -positron emission tomography and computed tomography scan (PETC/CT) 2 weeks after the vaccination demonstrated hypermetabolism in the left shoulder with the forearm prominent (maximum standardized uptake value 7.5) but did not show lymphadenopathy in the axillary region (Figure 1, arrow). COVID limb on FDG-PET/CT imaging Here, we report the Spikevax-relevant diffuse and persistent inflammation of muscles, illustrated by the FDG PET/CT scan. [Extracted from the article]

Published
2022
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