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4. Implementation of NUDT15 Genotyping to Prevent Azathioprine‐Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population

Author

Wang, Chuang‐Wei, Chi, Min‐Hui, Tsai, Tsen‐Fang, Yu, Kuang‐Hui, Kao, Hsiao‐Wen, Chen, Hsiang‐Cheng, Chen, Chun‐Bing, Lu, Chun‐Wei, Chen, Wei‐Ti, Chang, Ya‐Ching, Chang, Chih‐Jung, Chang, Yun‐Ting, Wu, Yeong‐Jian Jan, Chang, Chee‐Jen, Huang, Yu Huei, Ng, Chau‐Yee, Huang, Po‐Wei, Lin, Yu‐Jr, Hui, Rosaline Chung‐Yee, Chung, Wen‐Hung, and Consortium, Taiwan Asian Severe Cutaneous Adverse Reaction

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Human Genome, Prevention, Genetics, Detection, screening and diagnosis, 2.1 Biological and endogenous factors, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Humans, Azathioprine, Prospective Studies, Genotype, Pyrophosphatases, Leukopenia, Immunosuppressive Agents, Autoimmune Diseases, Thrombocytopenia, Methyltransferases, Taiwan/Asian Severe Cutaneous Adverse Reaction Consortium, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia. Recent studies have identified genetic NUDT15 variants strongly associated with AZA-induced leukopenia in Asian patients. This study aimed to investigate the strength of above genetic association and evaluate the usefulness of prospective screening of the NUDT15 variants to prevent AZA-induced leukopenia in Chinese patients. AZA-induced leukopenia in patients with autoimmune disorders were enrolled from multiple medical centers in Taiwan/China between 2012 and 2017 to determine the strength of genetic association of NUDT15 or TPMT variants by whole exome sequencing (WES). Furthermore, a prospective study was conducted between 2018 and 2021 to investigate the incidence of AZA-induced leukopenia with and without genetic screening. The WES result showed the genetic variants of NUDT15 R139C (rs116855232) (P = 3.7 × 10-25 , odds ratio (OR) = 21.7, 95% confidence interval (95% CI) = 12.1-38.8) and NUDT15 rs746071566 (P = 4.2 × 10-9 , OR = 7.1, 95% CI = 3.7-13.7), but not TPMT, were associated with AZA-induced leukopenia and NUDT15 R139C variant shows the highest sensitivity with 92.5%. Furthermore, the targeted screening of 1,013 participants for NUDT15 R139C enabled those identified as carriers to use alternative immunosuppressants. This strategy resulted in a significant decrease in the incidence of AZA-induced leukopenia compared with historical incidence (incidence rate = from 7.6% decreased to 0.4%; P = 9.3 × 10-20 ). In conclusion, the NUDT15 R139C variant was strongly associated with AZA-induced leukopenia in Chinese patients. The genetic screening of NUDT15 R139C followed by use of alternative immunosuppressants in identified carriers effectively decreased the incidence of AZA leukopenia for patients with autoimmune disorders.

Published
2022

7. Frailty and Cognitive Function in Middle-Aged and Older Adults With Congenital Heart Disease

Author

Sasikumar, Navaneetha, Enomoto, Junko, Mizuno, Yoshiko, Leong, Ming Chern, Binto Sabran, Izzatun Nafsi, Ladak, Laila Akbar, Hasan, Babar, Siddiqui, Ayat, Moon, Ju Ryoung, Huh, June, Yang, Hsiao-Ling, Wang, Jou-Kou, Lu, Chun-Wei, Demir, Fatma, Öden, Tuğba, Tefera, Endale, Mwita, Julius, Ambassa, Jean-Claude, Mvondo, Charles, Fanka, Marcel, Yadeta, Dejuma, Alemayehu, Mulualem, Leye, Mohamed, Gueye, Khadija, Gabriel, Harald, Svhneider, Matthias, Seeliger, Selina, Budts, Werner, Van De Bruaene, Alexander, Moons, Philip, Goossens, Eva, Van Bulck, Liesbet, Rassart, Jessica, Luyckx, Koen, De Hosson, Michele, De Backer, Julie, Kaneva, Anna, Markova, Mila, Lykkeberg, Birgitte, Biyai, Miriam, Ladouceur, Magalie, Boubrit, Anissa, Thambo, Jean-Benoît, Ruissel, Amandine, Jore, Cecile, Amedro, Pascal, Abassi, Hamouda, Soltani, Sonia, Bredy, Charlene, Giannakoulas, George, Kosmidis, Diamantis, Ntiloudi, Despina, Callus, Edward, Pagliuca, Silvana, Bertoldo, Enrico Giuseppe, Fiolo, Valentina, Caruana, Maryanne, Swain, Justine, Grech, Neil, Xuereb, Rachel, Craus, Sarah, Bonello, Maria, Borg, Darren, Farrugia, Paul, Cardona, Joanne, Estensen, Mette-Elise, Andresen, Brith, Eriksen, Katrine, Areias, Maria Emília, Miranda, Joana, Areias, José Carlos, Cruz, Cristina, Macedo, Filipe, Ribeiro Nunes, Filipa Manuela, Barbosa de Bessa, Ana Maria, Espírito Santo, Sara Mafalda, Brito, Paula, Pereira, Marisa, Teixeira, Sofia, Marques, Brenda, Marques, Ana Raquel, Johansson, Bengt, Sandberg, Camilla, Cronesten, Helena, Dellborg, Mikael, Mandalenakis, Zacharias, Mattson, Eva, Christersson, Christina, Robertsson, Louise, Hlebowicz, Joanna, Ternrud, Linda, Thomet, Corina, Ruperti, Javier, Bouchardy, Judith, Brand, Fanny, Rutz, Tobias, Blanche, Coralie, van Melle, Joost P., Boer, Anna, Constantine, Andrew, Gatzoulis, Michael A., Dimopoulos, Konstantinos, Coats, Louise, McParlin, Debbie, Khairy, Paul, Proietti, Anna, Roy, Veronique, Windram, Jonathan, Jandura, Deborah, Jameson, Susan, Major, Melissa, Mahadevan, Vaikom Subremanian, Nguyen, Thomas, Sarwary, Shabir, Saidi, Arwa, Breault, Leah, Colon, Dalia Lopez, Cedars, Ari, Kutty, Shelby, Ko, Jong, Valente, Anne Marie, Brainard, Sarah, Reichman, Jeffrey, Zaidi, Ali, Amlani, Amrin, Jackson, Jamie, Swenski, Taylor, Neville, Steven, Kovacs, Adrienne, McGrath, Lidija, Taunton, Marshall, Kim, Yuli, Carducci, Jessica, Bashey, Saffy, Alday, Luis, Lousararian, Marina, Maisuls, Héctor, Quinteros, Marisa, Lucero, Mónica, Ortiz, Lucia, Amaral, Fernando, Schmidt, Andre, Manso, Paulo Henrique, Pavão, Rafael Brolio, Reyes, Fernando Baraona, Arancibia, M. Francisca, Araujo, John Jairo, Súarez, Alberto Hernadez, Menahem, Samuel, Wijayarathne, Pasangi Madhuka, Daelman, Bo, Kovacs, Adrienne H., Schmidt, André, and de Hosson, Michèle

Published
2024
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8. Anxiety and Depression in Adults With Congenital Heart Disease

Author

Kovacs, Adrienne H., Luyckx, Koen, Thomet, Corina, Budts, Werner, Enomoto, Junko, Sluman, Maayke A., Lu, Chun-Wei, Jackson, Jamie L., Khairy, Paul, Cook, Stephen C., Chidambarathanu, Shanthi, Alday, Luis, Estensen, Mette-Elise, Dellborg, Mikael, Berghammer, Malin, Johansson, Bengt, Mackie, Andrew S., Menahem, Samuel, Caruana, Maryanne, Veldtman, Gruschen, Soufi, Alexandra, Jameson, Susan M., Callus, Edward, Kutty, Shelby, Oechslin, Erwin, Van Bulck, Liesbet, and Moons, Philip

Published
2024
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18. Taiwanese Dermatological Association consensus recommendations for the diagnosis, treatment, and management of generalized pustular psoriasis

Author

Hsu, Chao-Kai, primary, Huang, Yu-Huei, additional, Chang, Chung-Hsing, additional, Chen, Yi-Ju, additional, Chiu, Tsu-Man, additional, Chung, Wen-Hung, additional, Jang, Chiau-Sheng, additional, Lin, Shang-Hung, additional, Lu, Chun-Wei, additional, Wu, Nan-Lin, additional, Yu, Sebastian, additional, and Tsai, Tsen-Fang, additional

Published
2024
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26. Risk Factors of Long-Term Sequelae After Transcatheter Closure of Perimembranous Ventricular Septal Defect in Young Children

Author

Chin, Chia-Yi, primary, Chen, Chun-An, additional, Fu, Chun-Min, additional, Hsu, Jui-Yu, additional, Lin, Hsin-Chia, additional, Chiu, Shuenn-Nan, additional, Chang, Ya-Mei, additional, Lu, Chun-Wei, additional, Chou, Heng-Wen, additional, Huang, Shu-Chien, additional, Chen, Yih-Sharng, additional, Wu, Mei-Hwan, additional, Wang, Jou-Kou, additional, and Lin, Ming-Tai, additional

Published
2024
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28. Disseminated intravascular coagulation in Stevens-Johnson syndrome and toxic epidermal necrolysis

Author

Chen, Chun-Bing, Hsu, Tsun-Hao, Chung-Yee Hui, Rosaline, Lu, Chun-Wei, Chen, Wei-Ti, Chiang, Pin-Hsuan, Wang, Chuang-Wei, Chuang, Shiow-Shuh, Yang, Jui-Yung, Yang, Shih-Yi, Chang, Shu-Ying, Hsiao, Yen-Chang, Kao, Kuo-Chin, Hu, Han-Chung, Wu, Ting-Shu, Hsu, Chao-Wei, Hui-Kang Ma, David, Chen, Shin-Yi, Tian, Ya-Chung, Cheng, Chi-Yuan, Chen, Chi-Hua, Chi, Min-Hui, Wu, Ming-Ying, Liu, Ren-Feng, Wang, Chi-Hui, Chang, Ya-Ching, Lin, Jing-Yi, Ho, Hsin-Chun, Yu-Wei Lin, Yang, Chang, Chee Jen, Lin, Yu-Jr, Ku, Cheng-Lung, Hung, Shuen-Iu, and Chung, Wen-Hung

Published
2021
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30. Atrial arrhythmias and patient-reported outcomes in adults with congenital heart disease: An international study

Author

Casteigt, Benjamin, Samuel, Michelle, Laplante, Laurence, Shohoudi, Azadeh, Apers, Silke, Kovacs, Adrienne H., Luyckx, Koen, Thomet, Corina, Budts, Werner, Enomoto, Junko, Sluman, Maayke A., Lu, Chun-Wei, Jackson, Jamie L., Cook, Stephen C., Chidambarathanu, Shanthi, Alday, Luis, Eriksen, Katrine, Dellborg, Mikael, Berghammer, Malin, Johansson, Bengt, Mackie, Andrew S., Menahem, Samuel, Caruana, Maryanne, Veldtman, Gruschen, Soufi, Alexandra, Fernandes, Susan M., White, Kamila, Callus, Edward, Kutty, Shelby, Brouillette, Judith, Moons, Philip, and Khairy, Paul

Published
2021
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32. Detecting Lesional Granulysin Levels for Rapid Diagnosis of Cytotoxic T lymphocyte–Mediated Bullous Skin Disorders

Author

Chen, Chun-Bing, Kuo, Kang-Ling, Wang, Chuang-Wei, Lu, Chun-Wei, Chung-Yee Hui, Rosaline, Lu, Kun-Lin, Chang, Wan-Chun, Chen, Wei-Ti, Yun, Fu, Teng, Yu-Chuan, Lee, Hua-En, Lin, Jing-Yi, Ho, Hsin-Chun, Chi, Min-Hui, Yu-Wei Lin, Yang, Chang, Chee Jen, Lin, Yu, Jr., Ku, Cheng-Lung, Hung, Shuen-Iu, Chang, Ya-Ching, and Chung, Wen-Hung

Published
2021
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33. Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries

Author

Moons, Philip, Luyckx, Koen, Thomet, Corina, Budts, Werner, Enomoto, Junko, Sluman, Maayke A., Lu, Chun-Wei, Jackson, Jamie L., Khairy, Paul, Cook, Stephen C., Chidambarathanu, Shanthi, Alday, Luis, Eriksen, Katrine, Dellborg, Mikael, Berghammer, Malin, Johansson, Bengt, Mackie, Andrew S., Menahem, Samuel, Caruana, Maryanne, Veldtman, Gruschen, Soufi, Alexandra, Fernandes, Susan M., White, Kamila, Callus, Edward, Kutty, Shelby, Ombelet, Fouke, Apers, Silke, and Kovacs, Adrienne H.

Published
2021
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36. Liver fibrosis detected by diffusion-weighted magnetic resonance imaging and its functional correlates in Fontan patients.

Author

Lu, Chun-Wei, Wu, Chih-Horng, Huang, Miao-Tzu, Lee, Chee-Seng, Chen, Huey-Ling, Lin, Ming-Tai, Chiu, Shuenn-Nan, Tseng, Wei-Chieh, Chen, Chun-An, Wang, Jou-Kou, and Wu, Mei-Hwan

Subjects
*DIFFUSION magnetic resonance imaging, *HEPATIC fibrosis, *MAGNETIC resonance imaging, *FUNCTIONAL magnetic resonance imaging, *CARDIAC surgery
Abstract

OBJECTIVES The evaluation of Fontan-associated liver disease is often challenging. Diffusion-weighted magnetic resonance imaging can detect hepatic fibrosis from capillary perfusion and diffusion abnormalities from extracellular matrix accumulation. This study investigated its role in the evaluation of liver disease in Fontan patients and explored possible diagnostic methods for early detection of advanced liver fibrosis. METHODS Stable adult Fontan patients who could safely be examined with magnetic resonance imaging were enrolled, and blood biomarkers, transient elastography were also examined. RESULTS Forty-six patients received diffusion-weighted imaging; and 58.7% were diagnosed with advanced liver fibrosis (severe liver fibrosis, 37.0%, and cirrhosis 21.7%). Two parameters of hepatic dysfunction, platelet counts (Spearman's ρ: –0.456, P  = 0.001) and cholesterol levels (Spearman's ρ: –0.383, P  = 0.009), decreased with increasing severity of fibrosis. Using transient elastography, a cut-off value of 14.2 kPa predicted the presence of advanced liver fibrosis, but with a low positive predictive value. When we included platelet count, cholesterol, post-Fontan years and transient elastography values as a composite, the capability of predicting advanced liver fibrosis was the most satisfactory (C statistic 0.817 ± 0.071, P  < 0.001). A cut-off value of 5.0 revealed a sensitivity of 78% and a specificity of 82%. CONCLUSIONS In Fontan patients, diffusion-weighted imaging was helpful in detecting liver fibrosis that was correlated with hepatic dysfunction. A simple score was proposed for long-term surveillance and early detection of advanced liver disease in adult Fontan patients. For adult Fontan patients with a calculated score > 5.0, we may consider timely diffusion-weight imaging and early management for liver complications. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Health-promoting lifestyle and life satisfaction in full-time employed adults with congenital heart disease: grit as a mediator.

Author

Liu, Yu-Shiu, Lu, Chun-Wei, Chung, Hung-Tao, Wang, Jou-Kou, Su, Wen-Jen, and Chen, Chi-Wen

Subjects
*EMPLOYEE psychology, *CONGENITAL heart disease, *LIFESTYLES, *CROSS-sectional method, *PEARSON correlation (Statistics), *SATISFACTION, *T-test (Statistics), *STRESS management, *INCOME, *RESEARCH funding, *QUESTIONNAIRES, *SEX distribution, *DESCRIPTIVE statistics, *CHI-squared test, *AGE distribution, *SEVERITY of illness index, *HEALTH behavior, *STATISTICS, *PERSONALITY, *MARITAL status, *COURAGE, *DATA analysis software, *CONFIDENCE intervals, *SOCIAL support, *EDUCATIONAL attainment, *CARDIAC surgery, *ADULTS
Abstract

Aims Enhancing life satisfaction is vital for adults with congenital heart disease (ACHD). Life satisfaction potentially correlates with a health-promoting lifestyle and grit. However, the mediating role of grit—a trait marked by perseverance and long-term goal-oriented passion—between a health-promoting lifestyle and life satisfaction in ACHD remains unverified. This study aimed to examine the relationships between health-promoting lifestyle, grit, and life satisfaction in full-time employed ACHD and to confirm the mediating role of grit. Methods and results A total of 181 full-time employed ACHD aged 20–59 years with patient-reported New York Heart Association classes I–IV were recruited from two medical centres in northern Taiwan. Participants completed questionnaires, including the short version of the Chinese Health-Promoting Lifestyle Profile Scale, Grit-10 Scale, and Satisfaction with Life Scale between February and December 2022. Data analysis employed the Hayes PROCESS macro. Health-promoting lifestyle, grit, and life satisfaction were discovered to be positively correlated. Overall grit score was a partial mediator between a health-promoting lifestyle and life satisfaction, accounting for 20% of the total variation. Of the grit domains, perseverance served as a partial mediator between a health-promoting lifestyle and life satisfaction, accounting for 32% of the total variation, whereas passion had a nonsignificant mediation effect. Conclusion A health-promoting lifestyle boosts ACHD individuals' life satisfaction through grit, particularly perseverance. Integrating grit into such a lifestyle could benefit from comprehending support systems and influential factors aiding grit development for enhanced life satisfaction. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Implantable cardioverter-defibrillators and patient-reported outcomes in adults with congenital heart disease: An international study

Author

Lévesque, Valérie, Laplante, Laurence, Shohoudi, Azadeh, Apers, Silke, Kovacs, Adrienne H., Luyckx, Koen, Thomet, Corina, Budts, Werner, Enomoto, Junko, Sluman, Maayke A., Lu, Chun-Wei, Jackson, Jamie L., Cook, Stephen C., Chidambarathanu, Shanthi, Alday, Luis, Eriksen, Katrine, Dellborg, Mikael, Berghammer, Malin, Johansson, Bengt, Mackie, Andrew S., Menahem, Samuel, Caruana, Maryanne, Veldtman, Gruschen, Soufi, Alexandra, Fernandes, Susan M., White, Kamila, Callus, Edward, Kutty, Shelby, Brouillette, Judith, Casteigt, Benjamin, Moons, Philip, and Khairy, Paul

Published
2020
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39. A structured approach with Swiss cheese model to reduce vascular adverse events of filler injections.

Author

Huang, Yau‐Li, Chi, Ching‐Chi, Chang, Shyue‐Luen, Hu, Sindy, Lee, Mei‐Ching, Lu, Chun‐Wei, Chung, Wen‐Hung, Lin, Tsai‐Ming, and Cheng, Chun‐Yu

Subjects
ARRAIGNMENT, INJECTIONS, CHEESE, RISK assessment
Abstract

Background: Filler injection is among the most popular nonsurgical aesthetic procedures worldwide. Though relatively noninvasive, filler injection can lead to severe vascular adverse events. Even though the incidence is rare, it may cause devastating and irreversible outcomes. A Swiss cheese model has been widely applied for risk analysis and management approach in medical field. Aims: In this review article, we adopt the Swiss cheese model and create a structured approach to prevent severe vascular complications caused by filler injections. Methods: We reviewed the current literature regarding the knowledge and techniques of preventing vascular adverse events in the filler injection. Results: We propose four structured strategies in this model to reduce the risk of severe vascular adverse events of filler injections, including clinical facial anatomy, safe filler injection principles, real time imaging and auxiliary instruments, and implication of checklist. Conclusion: This review provides clinicians a structured approach before and during the filler injection procedure to reduce the risk of vascular adverse events and improve its safety and outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Normal ECG standards and percentile charts for infants, children and adolescents

Author

Lue, Hung-Chi, primary, Wu, Mei-Hwan, additional, Wang, Jou-Kou, additional, Lin, Ming-Tai, additional, Lu, Chun-Wei, additional, Chiu, Shuenn-Nan, additional, Chen, Chun-An, additional, Wu, En-Ting, additional, Wang, Ching-Chia, additional, Fu, Chun-Min, additional, Tseng, Wei-Chieh, additional, Chang, Wei-Hsuan, additional, and Lee, Meng-Chang, additional

Published
2023
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50. Characteristics of immune response profile in patients with immediate allergic and autoimmune urticarial reactions induced by SARS-CoV-2 vaccines

Author

Wang, Chuang-Wei, primary, Chen, Chun-Bing, additional, Lu, Chun-Wei, additional, Chen, Wei-Ti, additional, Hui, Rosaline Chung-Yee, additional, Chiu, Tsu-Man, additional, Chi, Min-Hui, additional, Lin, Jing-Chi, additional, Huang, Yu-Huei, additional, Chang, Ya-Ching, additional, Wu, Jennifer, additional, Chen, Kuan-Yu, additional, Lin, Yang Yu-Wei, additional, Ger, Tzong-Yun, additional, Lin, Jing Yi, additional, Tsai, Wan-Ting, additional, Pan, Yen-Ju, additional, and Chung, Wen-Hung, additional

Published
2023
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