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20 results on '"Lu, Gonggong"'

7. Dopamine‐Integrated Nanointerface between Fibrillar Matrix and Hydrophilic Nanohydroxyapatite Regulates Immune Microenvironment to Boost Endogenous Bone Regeneration (Adv. Funct. Mater. 16/2023)

Author

Li, Xing, primary, Li, Zhulian, additional, Wang, Peilei, additional, Lu, Gonggong, additional, Tong, Lei, additional, Liu, Quanying, additional, Chen, Yafang, additional, Lin, Jiangli, additional, Luo, En, additional, Liang, Jie, additional, Jiang, Qing, additional, Fan, Yujiang, additional, Zhang, Xingdong, additional, and Sun, Yong, additional

Published
2023
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9. Covalently Grafted Biomimetic Matrix Reconstructs the Regenerative Microenvironment of the Porous Gradient Polycaprolactone Scaffold to Accelerate Bone Remodeling

Author

Liu, Quanying, primary, Chen, Manyu, additional, Gu, Peiyang, additional, Tong, Lei, additional, Wang, Peilei, additional, Zhu, Jiayi, additional, Xu, Yang, additional, Lu, Gonggong, additional, Luo, En, additional, Liang, Jie, additional, Fan, Yujiang, additional, Zhang, Xingdong, additional, and Sun, Yong, additional

Published
2023
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15. DNA Origami Enhanced Cytokine Immunotherapy for Alleviating Renal Ischemia-Reperfusion Injury

Author

Fan, Yu, Wang, Chengshi, Dai, Wenshu, Zhou, Yaojia, Lu, Gonggong, Li, Wei, Li, Ling, and Lin, Tao

Abstract

Renal ischemia-reperfusion injury (IRI) is a major contributing factor to the development of acute kidney injury (AKI) and has resulted in considerable morbidity and mortality. Persistent inflammatory responses and excessive reactive oxygen species (ROS) in the kidney following IRI can severely delay tissue repair, making it challenging to effectively promote IRI regeneration. Herein, we report an approach to enhance immunotherapy using interleukin-10 (IL-10) to promote IRI regeneration by loading IL-10 onto rectangular DNA origami nanostructures (rDON). rDON can significantly enhance the renal accumulation and retention time of IL-10, enabling it to effectively polarize type 1 macrophages into type 2 macrophages, thereby significantly reducing proinflammatory factors and increasing anti-inflammatory factors. In addition, DNA origami helps mitigate the harmful effects of ROS during renal IRI. The administration of IL-10-loaded DNA origami effectively improves kidney function, resulting in a notable reduction in blood urea nitrogen, serum uric acid, and serum creatinine levels. Our study demonstrates that the integration of anti-inflammatory cytokines within DNA origami holds promise as a strategic approach for cytokine immunotherapy in patients with AKI and other renal disorders.

Published
2024
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19. Synthesis and photoluminescence characteristics of Sm3+-doped Bi4Si3O12 red-emitting phosphor.

Author

Lu, Gonggong, Qiu, Kehui, Li, Junfeng, Zhang, Wentao, and Yuan, Xiqiang

Abstract

A series of novel red-emitting Sm3+-doped bismuth silicate phosphors, Bi4Si3O12:xSm3+ (0.01 ≤ x ≤ 0.06), were prepared via the sol-gel route. The phase of the synthesized samples calcinated at 800 °C is isostructural with Bi4Si3O12 according to X-ray diffraction results. Under excitation with 405 nm light, some typical peaks of Sm3+ ions centered at 566, 609, 655 and 715 nm are found in the emission spectra of the Sm3+-doped Bi4Si3O12 phosphors. The strongest peak located at 609 nm is due to 4G5/2-6H7/2 transition of Sm3+. The luminescence intensity reaches its maximum value when the Sm3+ ion content is 4 mol%. The results suggest that Bi4Si3O12:Sm3+ may be a potential red phosphor for white light-emitting diodes. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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20. Synthesis and photoluminescence characteristics of Sm 3 + -doped Bi 4 Si 3 O 12 red-emitting phosphor.

Author

Lu G, Qiu K, Li J, Zhang W, and Yuan X

Subjects
Photochemical Processes, Bismuth chemistry, Luminescence, Oxygen chemistry, Samarium chemistry, Silicon chemistry
Abstract

A series of novel red-emitting Sm 3 + -doped bismuth silicate phosphors, Bi 4 Si 3 O 12 :xSm 3 + (0.01 ≤ x ≤ 0.06), were prepared via the sol-gel route. The phase of the synthesized samples calcinated at 800 °C is isostructural with Bi 4 Si 3 O 12 according to X-ray diffraction results. Under excitation with 405 nm light, some typical peaks of Sm 3 + ions centered at 566, 609, 655 and 715 nm are found in the emission spectra of the Sm 3 + -doped Bi 4 Si 3 O 12 phosphors. The strongest peak located at 609 nm is due to 4 G 5 /2 - 6 H 7 /2 transition of Sm 3 + . The luminescence intensity reaches its maximum value when the Sm 3 + ion content is 4 mol%. The results suggest that Bi 4 Si 3 O 12 :Sm 3 + may be a potential red phosphor for white light-emitting diodes. Copyright © 2016 John Wiley & Sons, Ltd., (Copyright © 2016 John Wiley & Sons, Ltd.)

Published
2017
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