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32 results on '"Lu, Hui-Meng"'

3. Phylogenomic analyses provide insights into primate evolution

Author

Shao, Yong, primary, Zhou, Long, additional, Li, Fang, additional, Zhao, Lan, additional, Zhang, Bao-Lin, additional, Shao, Feng, additional, Chen, Jia-Wei, additional, Chen, Chun-Yan, additional, Bi, Xupeng, additional, Zhuang, Xiao-Lin, additional, Zhu, Hong-Liang, additional, Hu, Jiang, additional, Sun, Zongyi, additional, Li, Xin, additional, Wang, Depeng, additional, Rivas-González, Iker, additional, Wang, Sheng, additional, Wang, Yun-Mei, additional, Chen, Wu, additional, Li, Gang, additional, Lu, Hui-Meng, additional, Liu, Yang, additional, Kuderna, Lukas F. K., additional, Farh, Kyle Kai-How, additional, Fan, Peng-Fei, additional, Yu, Li, additional, Li, Ming, additional, Liu, Zhi-Jin, additional, Tiley, George P., additional, Yoder, Anne D., additional, Roos, Christian, additional, Hayakawa, Takashi, additional, Marques-Bonet, Tomas, additional, Rogers, Jeffrey, additional, Stenson, Peter D., additional, Cooper, David N., additional, Schierup, Mikkel Heide, additional, Yao, Yong-Gang, additional, Zhang, Ya-Ping, additional, Wang, Wen, additional, Qi, Xiao-Guang, additional, Zhang, Guojie, additional, and Wu, Dong-Dong, additional

Published
2023
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4. iORbase: A database for the prediction of the structures and functions of insect olfactory receptors.

Author

Li, Qian, Zhang, Yi‐Feng, Zhang, Tian‐Min, Wan, Jia‐Hui, Zhang, Yu‐Dan, Yang, Hui, Huang, Yuan, Xu, Chang, Li, Gang, and Lu, Hui‐Meng

Subjects
INSECT olfactory receptors, OLFACTORY receptors, PROTEIN structure prediction, DATABASES, INSECT pheromones, INSECT behavior
Abstract

Insect olfactory receptors (iORs) with atypical 7‐transmembrane domains, unlike Chordata olfactory receptors, are not in the GPCR protein family. iORs selectively bind to volatile ligands in the environment and affect essential insect behaviors. In this study, we constructed a new platform (iORbase, https://www.iorbase.com) for the structural and functional analysis of iORs based on a combined algorithm for gene annotation and protein structure prediction. Moreover, it provides the option to calculate the binding affinities and binding residues between iORs and pheromone molecules by virtual screening of docking. Furthermore, iORbase supports the automatic structural and functional prediction of user‐submitted iORs or pheromones. iORbase contains the well‐analyzed results of approximately 6 000 iORs and their 3D protein structures identified from 59 insect species and 2 077 insect pheromones from the literature, as well as approximately 12 million pairs of simulated interactions between functional iORs and pheromones. We also built 4 online modules, iORPDB, iInteraction, iModelTM, and iOdorTool to easily retrieve and visualize the 3D structures and interactions. iORbase can help greatly improve the experimental efficiency and success rate, identify new insecticide targets, or develop electronic nose technology. This study will shed light on the olfactory recognition mechanism and evolutionary characteristics from the perspectives of omics and macroevolution. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Phylogenomic analyses provide insights into primate evolution

Author

Shao, Yong, Zhou, Long, Li, Fang, Zhao, Lan, Zhang, Bao Lin, Shao, Feng, Chen, Jia Wei, Chen, Chun Yan, Bi, Xupeng, Zhuang, Xiao Lin, Zhu, Hong Liang, Hu, Jiang, Sun, Zongyi, Li, Xin, Wang, Depeng, Rivas-González, Iker, Wang, Sheng, Wang, Yun Mei, Chen, Wu, Li, Gang, Lu, Hui Meng, Liu, Yang, Kuderna, Lukas F.K., Farh, Kyle Kai How, Fan, Peng Fei, Yu, Li, Li, Ming, Liu, Zhi Jin, Tiley, George P., Yoder, Anne D., Roos, Christian, Hayakawa, Takashi, Marques-Bonet, Tomas, Rogers, Jeffrey, Stenson, Peter D., Cooper, David N., Schierup, Mikkel Heide, Yao, Yong Gang, Zhang, Ya Ping, Wang, Wen, Qi, Xiao Guang, Zhang, Guojie, and Wu, Dong Dong

Abstract

Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, including 27 genomes first reported here, with many from previously less well represented groups, the New World monkeys and the Strepsirrhini. Our analyses reveal heterogeneous rates of genomic rearrangement and gene evolution across primate lineages. Thousands of genes under positive selection in different lineages play roles in the nervous, skeletal, and digestive systems and may have contributed to primate innovations and adaptations. Our study reveals that many key genomic innovations occurred in the Simiiformes ancestral node and may have had an impact on the adaptive radiation of the Simiiformes and human evolution.

Published
2023

6. Predicting Drug-Target Interactions Between New Drugs and New Targets via Pairwise K-nearest Neighbor and Automatic Similarity Selection

Author

Shi, Jian-Yu, Li, Jia-Xin, Lu, Hui-Meng, Zhang, Yong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, He, Xiaofei, editor, Gao, Xinbo, editor, Zhang, Yanning, editor, Zhou, Zhi-Hua, editor, Liu, Zhi-Yong, editor, Fu, Baochuan, editor, Hu, Fuyuan, editor, and Zhang, Zhancheng, editor

Published
2015
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7. Comparative mitochondrial genomes of four species of Sinopodisma and phylogenetic implications (Orthoptera, Melanoplinae)

Author

Huang Yuan, Lu Hui-Meng, Li Xia, Qiu Zhongying, Yuan Feng Hao, Chang Huihui, and Gou Xingchun

Subjects
0106 biological sciences, 0301 basic medicine, Insecta, Arthropoda, Orthoptera, Locus (genetics), mitogenome phylogeny Sinopodisma, phylogeny, 010603 evolutionary biology, 01 natural sciences, Genome, 03 medical and health sciences, Monophyly, Phylogenetics, lcsh:Zoology, Animalia, lcsh:QL1-991, Gene, Ecology, Evolution, Behavior and Systematics, Sinopodisma, biology, Phylogenetic tree, mitogenome, biology.organism_classification, Acrididae, 030104 developmental biology, Evolutionary biology, Melanoplinae, Animal Science and Zoology, Acridoidea
Abstract

In this study, the whole mitochondrial genomes (mitogenomes) from four species were sequenced. The complete mitochondrial genomes of Sinopodisma pieli, S. houshana, S. qinlingensis, and S. wulingshanensis are 15,857 bp, 15,818 bp, 15,843 bp, and 15,872 bp in size, respectively. The 13 protein-coding genes (PCGs) begin with typical ATN codons, except for COXI in S. qinlingensis, which begins with ACC. The highest A+T content in all the sequenced orthopteran mitogenomes is 76.8% (S. qinlingensis), followed by 76.5% (S. wulingshanensis), 76.4% (S. pieli) and 76.4% (S. houshana) (measured on the major strand). The long polythymine stretches (T-stretch) in the A+T-rich region of the four species are not adjacent to the trnI locus but are inside the stem-loop sequences on the major strand. Moreover, several repeated elements are found in the A+T-rich region of the four species. Phylogenetic analysis based on 53 mitochondrial genomes using Bayesian Inference (BI) and Maximum Likelihood (ML) revealed that Melanoplinae (Podismini) was a monophyletic group; however, the monophyly of Sinopodisma was not supported. These data will provide important information for a better understanding of the phylogenetic relationship of Melanoplinae.

Published
2020

12. Recent treatment progress of triple negative breast cancer

Author

Lu Hui-Meng, Gong Zi-Qian, Yang Chang-Qing, Zhao Shi-Qi, Zhang Chen-Yan, Zhao Gang, Liu Jie, Yin Dachuan, Zhou Ren-Bin, Xu Ran, and Zhu Kun

Subjects
Oncology, medicine.medical_specialty, Chemotherapy, Side effect, business.industry, medicine.medical_treatment, Biophysics, Estrogen receptor, Triple Negative Breast Neoplasms, Disease, medicine.disease, Prognosis, Metastasis, Breast cancer, Internal medicine, Progesterone receptor, medicine, Humans, Neoplasm Metastasis, business, Molecular Biology, Triple-negative breast cancer, Signal Transduction
Abstract

Breast cancer (BC) is a serious worldwide disease that threatens women's health. Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other BC types due to its high molecular heterogeneity, metastatic potential and poor prognosis. TNBC lacks of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), so there are still no effective treatment methods for TNBC. Here, we reviewed the classification of TNBC, its molecular mechanisms of pathogenesis, treatment methods and prognosis. Finding effective targets is critical for the treatment of TNBC. Also, refining the classification of TNBC is benefited to choose the treatment of TNBC, because the sensitivity of chemotherapy is different in different TNBC. Some new treatment methods have been proposed in recent years, such as nutritional therapy and noncoding RNA treatment methods. There are some disadvantages, such as the side effect on normal cells after nutrient deprivation, low specificity and instability of noncoding RNA. More studies are necessary to improve the treatment of TNBC.

Published
2019

15. Uncertainties in crystallization of hen-egg white lysozyme: reproducibility issue

Author

Yin, Da-Chuan, Lu, Hui-Meng, Ye, Ya-Jing, Li, Hai-Sheng, Luo, Hui-Min, Wakayama, Nobuko I., and Inatomi, Yuko

Subjects
Reproducibility, Materials science, Analytical chemistry, Nucleation, General Chemistry, Condensed Matter Physics, Isothermal process, law.invention, Tetragonal crystal system, Temperature gradient, chemistry.chemical_compound, Crystallography, chemistry, law, General Materials Science, Orthorhombic crystal system, Crystallization, Lysozyme
Abstract

Accepted: 2007-10-04, 資料番号: SA1000028000

Published
2008

19. Effect of Audible Sound on Protein Crystallization

Author

Zhang, Chen-Yan, primary, Wang, Yan, additional, Schubert, Robin, additional, Liu, Yue, additional, Wang, Meng-Yin, additional, Chen, Da, additional, Guo, Yun-Zhu, additional, Dong, Chen, additional, Lu, Hui-Meng, additional, Liu, Yong-Ming, additional, Wu, Zi-Qing, additional, Betzel, Christian, additional, and Yin, Da-Chuan, additional

Published
2016
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20. A protein crystallisation screening kit designed using polyethylene glycol as major precipitant

Author

Liu, Yue, primary, Zhang, Xian-Fang, additional, Zhang, Chen-Yan, additional, Guo, Yun-Zhu, additional, Xie, Si-Xiao, additional, Zhou, Ren-Bin, additional, Cheng, Qing-Di, additional, Yan, Er-Kai, additional, Liu, Ya-Li, additional, Lu, Xiao-Li, additional, Lu, Qin-Qin, additional, Lu, Hui-Meng, additional, Ye, Ya-Jing, additional, and Yin, Da-Chuan, additional

Published
2015
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21. A quality comparison of protein crystals grown under containerless conditions generated by diamagnetic levitation, silicone oil and agarose gel. Erratum

Author

Cao, Hui-Ling, primary, Sun, Li-Hua, additional, Li, Jian, additional, Tang, Lin, additional, Lu, Hui-Meng, additional, Guo, Yun-Zhu, additional, He, Jin, additional, Liu, Yong-Ming, additional, Xie, Xu-Zhuo, additional, Shen, He-Fang, additional, Zhang, Chen-Yan, additional, Guo, Wei-Hong, additional, Huang, Lin-Jun, additional, Shang, Peng, additional, He, Jian-Hua, additional, and Yin, Da-Chuan, additional

Published
2013
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29. Interferometry measurement of protein concentration evolution during crystallization and dissolution with improved reliability and versatility

Author

Yin, Da-Chuan, Luo, Hui-Meng, Li, Hai-Sheng, Lu, Hui-Meng, Ye, Ya-Jing, Inatomi, Yuko, and Wakayama, Nobuko I.

Subjects
Materials science, business.industry, Applied Mathematics, System of measurement, Crystal growth, law.invention, Interferometry, Optics, law, Time course, Crystallization, business, Biological system, Instrumentation, Engineering (miscellaneous), Dissolution, Protein concentration, Reliability (statistics)
Abstract

Interferometry is a widely used technique for real-time monitoring of concentration variation during processes in a solution like crystal growth and dissolution. This paper reports a protein concentration measurement system using a conventional Mach–Zehnder interferometer that allows monitoring the time course evolution of the protein concentration distribution during the processes of crystallization or dissolution. The demonstrated method showed improved reliability and versatility in that it (1) enables measurements under versatile temperature conditions and (2) eliminates the unpredictable errors caused by the environmental disturbances. The measurement system described in this paper can also be applied in measurements in other solution systems.

Published
2008

31. On the evolutionary trail of MagRs.

Author

Zhang J, Chang Y, Zhang P, Zhang Y, Wei M, Han C, Wang S, Lu HM, Cai T, and Xie C

Subjects
Animals, Biological Evolution, Evolution, Molecular, Phylogeny, Iron metabolism, Iron-Sulfur Proteins genetics, Iron-Sulfur Proteins metabolism, Iron-Sulfur Proteins chemistry
Abstract

Magnetic sense, or termed magnetoreception, has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and navigation. MagRs, highly conserved A-type iron-sulfur proteins, are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster biogenesis. However, the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain unclear. In this study, MagR sequences from 131 species, ranging from bacteria to humans, were selected for analysis, with 23 representative sequences covering species from prokaryotes to Mollusca, Arthropoda, Osteichthyes, Reptilia, Aves, and mammals chosen for protein expression and purification. Biochemical studies revealed a gradual increase in total iron content in MagRs during evolution. Three types of MagRs were identified, each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability, indicating continuous expansion of the functional roles of MagRs during speciation and evolution. This evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

Published
2024
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32. [Investigations of drug addiction mechanism in planarians].

Author

Lu HM, Yin DC, and Xu C

Subjects
Animals, Models, Animal, Drug Design, Planarians drug effects, Planarians physiology, Substance-Related Disorders
Abstract

Drug abuse harms people's health and lead to a series of economic, social and political problems. However, the problems of physical damage, physical dependence and withdrawal syndrome caused by drug abuse still exist. Planarians have been a new animal experimental model in vivo for neuropharmacology, because they possess a primitive central nervous system and neurotransmitter systems similarly to mammalians. In addition, they have the advantage of convenience and low cost and no ethics problems compared with mammalian models. The advantages of planarian as experimental model in vivo and the progress of the investigations of drug addiction mechanism in planarians are summarized, and the trends in this field are discussed in this review.

Published
2009

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