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19 results on '"Lu, Qiongyu"'

3. Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗

Author

Lu, Qiongyu, primary, Liu, Ziting, additional, Zhao, Luyao, additional, Xu, Linru, additional, Liu, Chu, additional, Li, Ling, additional, Cao, Yiren, additional, Li, Fengchan, additional, Wu, Lili, additional, Wang, Lei, additional, Chen, Ting, additional, You, Tao, additional, Ren, Lijie, additional, Wang, Guixue, additional, Tang, Chaojun, additional, and Zhu, Li, additional

Published
2023
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4. Single‐cell RNA‐seq reveals the links between the metabolic heterogeneity and cell identity in NBM and AML.

Author

Lu, Qiongyu, Qu, Wenqiang, Wen, Yuxin, Ke, Peng, Zhao, Luyao, Wang, Qingyuan, Chen, Suning, and Zeng, Zhao

Subjects
*ACUTE myeloid leukemia, *METABOLOMICS, *RNA sequencing, *HETEROGENEITY, *HEMATOPOIETIC stem cells, *CYTOTOXIC T cells
Abstract

This article explores the metabolic heterogeneity of acute myeloid leukemia (AML) at the single-cell level. The study reveals that AML cells exhibit distinct metabolic features and that metabolic heterogeneity is correlated with cell differentiation and certain genetic alterations. The researchers also found that primitive cell types in both normal bone marrow and AML display higher metabolic heterogeneity. The findings highlight the importance of understanding metabolic heterogeneity for identifying drug-resistant subtypes of cells and improving therapeutic interventions for AML. [Extracted from the article]

Published
2024
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7. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.

Author

Tang, Chaojun, Chen, Guona, Wu, Fan, Cao, Yiren, Yang, Fei, You, Tao, Liu, Chu, Li, Menglu, Hu, Shuhong, Ren, Lijie, Lu, Qiongyu, Deng, Wei, Xu, Ying, Wang, Guixue, Jo, Hanjoong, Zhang, Yonghong, Wu, Yi, Zabel, Brian A, and Zhu, Li

Subjects
INTEGRINS, ATHEROSCLEROTIC plaque, CHEMERIN, ATHEROSCLEROSIS, MONOCYTES, WESTERN diet
Abstract

Aims Chemoattractants and their cognate receptors are essential for leucocyte recruitment during atherogenesis, and atherosclerotic plaques preferentially occur at predilection sites of the arterial wall with disturbed flow (d-flow). In profiling the endothelial expression of atypical chemoattractant receptors (ACKRs), we found that Ackr5 (CCRL2) was up-regulated in an endothelial subpopulation by atherosclerotic stimulation. We therefore investigated the role of CCRL2 and its ligand chemerin in atherosclerosis and the underlying mechanism. Methods and results By analysing scRNA-seq data of the left carotid artery under d-flow and scRNA-seq datasets GSE131776 of ApoE−/− mice from the Gene Expression Omnibus database, we found that CCRL2 was up-regulated in one subpopulation of endothelial cells in response to d-flow stimulation and atherosclerosis. Using CCRL2−/−ApoE−/− mice, we showed that CCRL2 deficiency protected against plaque formation primarily in the d-flow areas of the aortic arch in ApoE−/− mice fed high-fat diet. Disturbed flow induced the expression of vascular endothelial CCRL2, recruiting chemerin, which caused leucocyte adhesion to the endothelium. Surprisingly, instead of binding to monocytic CMKLR1, chemerin was found to activate β2 integrin, enhancing ERK1/2 phosphorylation and monocyte adhesion. Moreover, chemerin was found to have protein disulfide isomerase-like enzymatic activity, which was responsible for the interaction of chemerin with β2 integrin, as identified by a Di-E-GSSG assay and a proximity ligation assay. For clinical relevance, relatively high serum levels of chemerin were found in patients with acute atherothrombotic stroke compared to healthy individuals. Conclusions Our findings indicate that d-flow-induced CCRL2 promotes atherosclerotic plaque formation via a novel CCRL2-chemerin-β2 integrin axis, providing potential targets for the prevention or therapeutic intervention of atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2023
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14. The global food governance system

Author

Oledinma, Akunna and Lu, Qiongyu

Abstract

Food governance has necessitated the monitoring of food along the supply chain especially where food import is becoming more popular in recent times.

Published
2018

17. Increased Levels of Plasma Soluble Sema4D in Patients with Heart Failure

Author

Lu, Qiongyu, primary, Dong, Ningzheng, additional, Wang, Qi, additional, Yi, Wenxiu, additional, Wang, Yuxin, additional, Zhang, Shengjie, additional, Gu, Haibo, additional, Zhao, Xin, additional, Tang, Xiaorong, additional, Jin, Boquan, additional, Wu, Qingyu, additional, Brass, Lawrence F., additional, and Zhu, Li, additional

Published
2013
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