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4. HYDROLYSATES OF SWIM BLADDER COLLAGEN FROM MIIUY CROAKER, MIICHTHYS MIIUY, ENHANCES LEARNING AND MEMORY IN MICE.

Author

Lu, Xin J., Jiong Chen, Chen, Mei Z., Lü, Ji N., Shi, Yu H., and Li, Hao Y.

Subjects
*MEMORY testing, *LEARNING ability testing, *COLLAGEN, *FUNCTIONAL foods, *SWIMMING, *MAZE tests, *FISH as food, *LABORATORY mice
Abstract

In East Asia, the swim bladder of miiuy croaker, Miichthys miiuy (SBM), is a traditional functional food to enhance learning and memory, but this concept is not confirmed by scientific methods. In this study, we isolated and hydrolyzed the SBM collagen (SBMC). Hydrolysates of SBMC were orally administrated for 28 days followed by the measurement of learning and memory in the Morris water maze. Learning and memory were enhanced in the SBMC- treated mice compared with the control. However, the SBMC treatment did not change the swim speed and visual acuity for performance in the water maze of mice. The mRNA expressions of learning and memory related genes were up-regulated in hippocampus of SBMC-treated mice. This study provides a kind of new prospective food to possibly enhance cognition in human. [ABSTRACT FROM AUTHOR]

Published
2010

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