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247 results on '"Lu, Xin-Jiang"'

13. TFPI from Erythroblasts Drives Heme Production in Central Macrophages Promoting Erythropoiesis in Polycythemia

Author

Lu, Xin-Jiang, primary, Ma, Jun-Kai, additional, Su, Lida, additional, Feng, Lin-Lin, additional, Pan, Li, additional, Danzeng, Qupei, additional, Li, Yanwei, additional, Shang, Tongyao, additional, Zhan, Xiao-Lin, additional, Chen, Si-Ying, additional, Ying, Shi-Bo, additional, Hu, Jian-Rao, additional, Chen, Xue Qun, additional, Zhang, Qi, additional, and Liang, Tingbo, additional

Published
2023
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15. CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia

Author

Wang, Tong Ying, primary, Xia, Fang Yuan, additional, Gong, Jing Wen, additional, Xu, Xiao Kang, additional, Lv, Min Chao, additional, Chatoo, Mahanand, additional, Shamsi, Bilal Haider, additional, Zhang, Meng Chen, additional, Liu, Qian Ru, additional, Liu, Tian Xing, additional, Zhang, Dan Dan, additional, Lu, Xin Jiang, additional, Zhao, Yang, additional, Du, Ji Zeng, additional, and Chen, Xue Qun, additional

Published
2022
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17. Wall temperature effects on shock wave/turbulent boundary layer interaction via direct numerical simulation

Author

Lu-Xin Jiang, Weidong Liu, Zhiwei Hu, Mingbo Sun, Ke Zhu, and Qian-cheng Wang

Subjects
Shock wave, 020301 aerospace & aeronautics, Materials science, Bubble, Root-mean-square speed, Direct numerical simulation, Aerospace Engineering, 02 engineering and technology, Mechanics, 01 natural sciences, Vortex, Physics::Fluid Dynamics, Boundary layer, 0203 mechanical engineering, Parasitic drag, 0103 physical sciences, Turbulence kinetic energy, 010303 astronomy & astrophysics
Abstract

Shockwave/turbulent boundary layer interaction on flat plate are investigated by using direct numerical simulation at different wall temperature of T w / T r = 0.5 , 1.0 , 2.0 respectively. Responses of skin friction, velocity profile and root mean square velocity profile are examined. Analysis on velocity profiles indicate that streamwise velocity in the outer part of boundary layer experiences a reduction with wall temperature going up. Skin friction decreases while wall is heating mainly caused by a lower velocity gradient near the wall at a high temperature. A lower skin friction on high wall temperature results in a stronger separation. The comparison of root mean square velocity profile shows turbulent kinetic energy is augmented on a heating wall. The maximum value moves closer to the wall with wall temperature increasing. The scale of separation bubble is amplified with wall temperature increasing. Near-wall streaks become unstable and get an increment in spanwise distance. The process of near-wall strip vortices evolving to complicated 3-dimonsional structures is accelerated and amplified in a high wall temperature. Counter-rotating vortex in reattachment process is evaluated in the three cases. The scale of such vortex gets larger when wall temperature gets higher. The spanwise distance between counter-rotating vortices rises obviously and break down to smaller coherent structures quicker.

Published
2021

30. Editorial: The Function of Phagocytes in Non-Mammals

Author

Lu, Xin-Jiang, Deng, Qing, and Thompson, Kim Dawn

Subjects
hemocytes, B cells, Phagocytes, Editorial, teleost, neutrophils, macrophage polarization, Immunology, Animals, non-mammals, macrophages
Published
2020

45. The interleukin-6 regulates the function of monocytes/macrophages (MO/MФ) via the interleukin-6 receptor β in ayu (Plecoglossus altivelis).

Author

Zhu, Kai, Lu, Xin-Jiang, Jian-Fei Lu, and Chen, Jiong

Subjects
*INTERLEUKIN-6 receptors, *RECOMBINANT proteins, *VIBRIO infections, *VIBRIO anguillarum, *INTERLEUKIN-6, *MONOCYTES
Abstract

Interleukin-6 (IL-6) is one of the most pleiotropic cytokines because of its wide range of effects on cells of the immune and non-immune systems in the body. However, the role of IL-6 in fish monocytes/macrophages (MO/MФ) is poorly understood. In this study, we cloned the cDNA sequence of the IL-6 gene from ayu (Plecoglossus altivelis) and demonstrated using a tissue distribution assay that ayu interleukin-6 (PaIL-6) mRNA is expressed in all tested tissues. Changes in expression were observed in immune tissues as well as in MO/MФ after a Vibrio anguillarum infection; subsequently, PaIL-6 was expressed and purified to prepare anti-PaIL-6 antibodies. Recombinant PaIL-6 protein (rPaIL-6) treatment enhanced pro-inflammatory cytokine expression. Ayu interleukin-6 receptor β (PaIL-6Rβ) knockdown resulted in decreased pro-inflammatory cytokine expression in MO/MФ treated with rPaIL-6, whereas no significant changes were observed after ayu interleukin-6 receptor α (PaIL-6Rα) knockdown in MO/MФ. PaIL-6 and PaIL-6Rβ knockdown in MO/MФ inhibited the phosphorylation of signal transducer and activator of transcription 1. Moreover, PaIL-6Rβ knockdown inhibited the phagocytic and bactericidal ability of ayu MO/MФ treated with rPaIL-6. These data indicate that PaIL-6 may be able to regulate the function of ayu MO/MФ. • We characterized an IL-6 gene from ayu. • IL-6 transcripts were altered in ayu upon Vibrio anguillarum infection. • Infection stimulated IL-6 expression in ayu monocytes/macrophages. • IL-6 regulated the functions of monocyte/macrophage. [ABSTRACT FROM AUTHOR]

Published
2019
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