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403 results on '"Lu, Zhihua"'

15. Impaired contractility of the circular striated urethral sphincter muscle may contribute to stress urinary incontinence in female zucker fatty rats

Author

Lee, Yung‐Chin, Lin, Guiting, Wang, Guifang, Reed‐Maldonado, Amanda, Lu, Zhihua, Wang, Lin, Banie, Lia, and Lue, Tom F

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Nutrition, Urologic Diseases, Neurosciences, Obesity, Animals, Electric Stimulation, Female, Muscle Contraction, Muscle, Skeletal, Rats, Rats, Zucker, Urethra, Urinary Bladder, Urinary Incontinence, Stress, electrical field stimulation, female rats, obesity, organ bath, urethral sphincter, Clinical Sciences, Urology & Nephrology, Clinical sciences
Abstract

AimObesity has been an independent risk factor for female stress urinary incontinence (SUI), the mechanism of this association remains unknown. The aim of this study is to validate the hypothesis that urethral dysfunction is a possible contributor to SUI in obese women.MethodsTen Zucker Fatty (ZF) (ZUC-Leprfa 185) and 10 Zucker Lean (ZL) (ZUC-Leprfa 186) female rats at 12-week-old were used in this experiment. The urethral sphincter rings were harvested from the bladder neck through to the most proximal 2/3 regions. In the organ bath study, single pulses of electrical field stimulation (EFS) were applied. For the fatiguing stimulation, repeated multi-pulse EFS with 70 mA were applied at frequency of 5 Hz for 5 min. Caffeine-containing Krebs' solution was administrated to contract the urethra until the contraction began to reach a plateau for 10 min. We performed immunofluorescence staining of the urethra after the experiment was finished.ResultsCompared to ZL controls, ZF rats had significantly impaired muscle contractile activity (MCA) (P

Published
2017

16. Artificial intelligence iterative reconstruction in abdominal CT of patients with irregular arm positioning: a case-by-case evaluation.

Author

Li, Jin, Meng, Ting, Zhang, Guozhi, Yu, Xiang, Lu, Zhihua, and Zhang, Weiguo

Subjects
COMPUTED tomography, ARTIFICIAL intelligence, CYSTIC kidney disease, SPLEEN, CIRRHOSIS of the liver
Abstract

Background: Streak artifacts induced by irregular arm positioning have been an issue in diagnosing the abdomen. Purpose: To illustrate the risk of misdiagnosis in abdominal computed tomography (CT) of patients with irregular arm positioning through a case-by-case evaluation and to test if it can be solved by the artificial intelligence iterative reconstruction (AIIR) algorithm. Material and Methods: By reviewing 5220 cases of chest and thoracoabdominal CT, 64 patients with irregular arm positioning were enrolled, whose image data were reconstructed using AIIR in addition to routine hybrid iterative reconstruction (HIR). Lesion detection for livers, spleens, kidneys, gallbladders, and pancreas on AIIR images, performed by two radiologists, was compared with those on HIR images. Discrepancies arising from AIIR images included both cases with additional abnormalities and those with corrections made on previous detections. For cases with discrepancies, artifact scores for organs where discrepancies were found, and contrast-to-noise ratios (CNRs) of cysts with discrepancies were compared between two image sets. Results: Additional abnormalities were detected for 15 cases: additional liver cirrhosis (n=2); additional gallbladder stone (n=1); additional cholecystitis (n=1), additional spleen nodule (n=1); additional kidney cysts (n=8); additional liver cysts (3); and additional spleen cyst (n=1). A spleen contusion was corrected for one case. All involved artifact scores were improved on AIIR images. CNRs of involved liver, kidney, and spleen cysts were improved by up to 539.7%, 538.5%, and 245.5%, respectively. Conclusion: Irregular arm positioning may induce a variety of misdiagnoses in abdominal CT, which is almost totally avoidable by the AIIR algorithm. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Akkermansia muciniphila alleviates colonic epithelial endoplasmic reticulum stress through activation of farnesoid X receptors in murine experimental colitis

Author

Bu, Fan, primary, Zhou, Qiao, additional, Dong, Yuwei, additional, Bao, Han, additional, Lu, Zhihua, additional, Yuan, Xiaomin, additional, Chen, Chen, additional, Jiang, Feng, additional, Tao, Yu, additional, Zhang, Wei, additional, Zhang, Dan, additional, Chen, Yugen, additional, and Wang, Qiong, additional

Published
2022
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50. High-efficiency synthesis of Co, N-doped carbon nanocages by ball milling-hard template method as an active catalyst for oxygen reduction reaction

Author

Lu Zhihua, Shuhan Yang, Wang Jing, Wenna Song, Jianhua Zhao, Jiang Liang, and Zhai Qianqian

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Electron transfer, Fuel Technology, Nanocages, chemistry, Chemical engineering, Hydrogen fuel, Methanol, 0210 nano-technology, Ball mill, Carbon, Template method pattern
Abstract

A facile and scalable method is developed for the high-efficiency synthesis of Co, N-doped carbon nanocages catalyst for the oxygen reduction reaction (ORR). During the synthesis, the precursors are uniformly distributed on the surface of potassium chloride (KCl) by high-energy ball milling. As evidenced, the N and Co elements are successfully doped and distributed uniformly on the surface of carbon nanocages. Owing to the distinctive nanocage architecture and the synergistic effects of Co, N and Co-NX coordination, the obtained Co, N–CNC-800 shows efficient ORR catalytic activity with an onset potential of 0.924 V (vs. RHE), and the number of electron transfer (n) is approximately 3.4. Furthermore, its stability and methanol tolerance are far superior to those of commercial 40% Pt/C. This simple and universal synthesis strategy is expected to be widely applied in the preparation of other heteroatom-doped carbon nanocages as catalysts in hydrogen fuel cells.

Published
2020

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