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13 results on '"Lu He Jun"'

5. Bis-perfluoroalkylation of aromatic compounds with sodium perfluoroalkanesulfinates

Author

Liu Jin‐Tao and Lu He‐Jun

Subjects
chemistry.chemical_compound, chemistry, Nucleophilic aromatic substitution, Sodium, Quinoline, Pyridine, Organic chemistry, chemistry.chemical_element, General Chemistry, Anisole, Excess sodium
Abstract

Bis-perfluoroalkylation of aromatic compounds such as dimethoxybenzenes (2, 4, 6), anisole (8), pyridine (10) and quinoline (13) was accomplished by reaction with excess sodium perfluoroalkanesulfinates, RFSO2Na (1), in the presence of Mn(OAc)3·2H2O under mild conditions. The reaction provides a facile method for the synthesis of bis-perfluoroalkylated aromatic compounds.

Published
2010
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6. Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

Author

Feng Ying, Feng Jun, Shen Guang Yuan, Leng Ying, Lin Zhi Gang, Wang Yang, Mong Xian Tai, Tang Peng Cho, Lu He Jun, Yan Pang Ke, Fu Jian Hong, Zhang Lei, Guan Dong Liang, Wang Lin, Yang Fang Long, Gong Ai Shen, She Gao Hong, Luo Jing Jing, and Wang Dan

Subjects
Dipeptidyl Peptidase 4, Clinical Biochemistry, Pharmaceutical Science, Type 2 diabetes, Biochemistry, Rats, Sprague-Dawley, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Pharmacokinetics, Oral glucose tolerance, Molecular Biology, Dipeptidyl peptidase-4, Octane, Biological evaluation, Dipeptidyl-Peptidase IV Inhibitors, Mice, Inbred ICR, Chemistry, Organic Chemistry, Glucose Tolerance Test, Octanes, medicine.disease, Rats, Diabetes Mellitus, Type 2, Molecular Medicine, Azo Compounds, Methyl group
Abstract

A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity.

Published
2010
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