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5 results on '"Lubczynska, MJ"'

1. Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence

Author

Binter AC, Kusters MSW, van den Dries MA, Alonso L, Lubczynska MJ, Hoek G, White T, Iñiguez C, Tiemeier H, and Guxens M

Subjects
Time series, Air pollution, Cohort studies, Neuroimaging, Child development
Abstract

Air pollution exposure during early-life is associated with altered brain development, but the precise periods of susceptibility are unknown. We aimed to investigate whether there are periods of susceptibility of air pollution between conception and preadolescence in relation to white matter microstructure and brain volumes at 9-12 years old. We used data of 3515 children from the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands (2002-2006). We estimated daily levels of nitrogen dioxide (NO2), and particulate matter (PM2.5 and PM2.5absorbance) at participants' homes during pregnancy and childhood using land-use regression models. Diffusion tensor and structural brain images were obtained when children were 9-12 years of age, and we calculated fractional anisotropy and mean diffusivity, and several brain structure volumes. We performed distributed lag non-linear modeling adjusting for socioeconomic and lifestyle characteristics. We observed specific periods of susceptibility to all air pollutants from conception to age 5 years in association with lower fractional anisotropy and higher mean diffusivity that survived correction for multiple testing (e.g., -0.85 fractional anisotropy (95%CI -1.43; -0.27) per 5 µg/m(3) increase in PM2.5 between conception and 4 years of age). We also observed certain periods of susceptibility to some air pollutants in relation to global brain and some subcortical brain volumes, but only the association between PM2.5 and putamen survived correction for multiple testing (172 mm(3) (95%CI 57; 286) per 5 µg/m(3) increase in PM2.5 between 4 months and 1.8 year of age). This study suggested that conception, pregnancy, infancy, toddlerhood, and early childhood seem to be susceptible periods to air pollution exposure for the development of white matter microstructure and the putamen volume. Longitudinal studies with repeated brain outcome measurements are needed for understanding the trajectories and the long-term effects of exposure to air pollution.

Published
2022

2. Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents

Author

Lubczynska, MJ, Muetzel, Ryan, El Marroun, Hanan, Hoek, G, Kooter, IM, Thomson, EM, Hillegers, Manon, Vernooij, Meike, White, Tonya, Tiemeier, Henning, Guxens Junyent, Monica, Lubczynska, MJ, Muetzel, Ryan, El Marroun, Hanan, Hoek, G, Kooter, IM, Thomson, EM, Hillegers, Manon, Vernooij, Meike, White, Tonya, Tiemeier, Henning, and Guxens Junyent, Monica

Abstract

Background: Studies investigating the relationship between exposure to air pollution and brain development using magnetic resonance images are emerging. However, most studies have focused only on prenatal exposures, and have included a limited selection of pollutants. Here, we aim to expand the current knowledge by studying pregnancy and childhood exposure to a wide selection of pollutants, and brain morphology in preadolescents. Methods: We used data from 3133 preadolescents from a birth cohort from Rotterdam, the Netherlands (enrollment: 2002–2006). Concentrations of nitrogen oxides, coarse, fine, and ultrafine particles, and composition of fine particles were estimated for participant's home addresses in pregnancy and childhood, using land use regression models. Structural brain images were obtained at age 9–12 years. We assessed the relationships of air pollution exposure, with brain volumes, and surface-based morphometric data, adjusting for socioeconomic and life-style characteristics, using single as well as multi-pollutant approach. Results: No associations were observed between air pollution exposures and global volumes of total brain, and cortical and subcortical grey matter. However, we found associations between higher pregnancy and childhood air pollution exposures with smaller corpus callosum, smaller hippocampus, larger amygdala, smaller nucleus accumbens, and larger cerebellum (e.g. -69.2mm3 hippocampal volume [95%CI -129.1 to -9.3] per 1ng/m3 increase in pregnancy exposure to polycyclic aromatic hydrocarbons). Higher pregnancy exposure to air pollution was associated with smaller cortical thickness while higher childhood exposure was associated with predominantly larger cortical surface area. Conclusion: Higher pregnancy or childhood exposure to several air pollutants was associated with altered volume of several brain structures, as well as with cortical thickness and surface area. Associations showed some similarity to del

Published
2021

4. Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

Author

Jorcano, A, Lubczynska, MJ, Pierotti, L, Altug, H, Ballester, F, Cesaroni, G, El Marroun, Hanan, Fernandez-Somoano, A, Freire, C, Hanke, W, Hoek, G, Ibarluzea, J, Iniguez, C, Jansen, Pauline, Lepeule, J, Markevych, I, Polanska, K, Porta, D, Schikowski, T, Slama, R, Standl, M, Tardon, A, Vrijkotte, TG, von Berg, A, Tiemeier, Henning, Sunyer, J, Guxens Junyent, Monica, Jorcano, A, Lubczynska, MJ, Pierotti, L, Altug, H, Ballester, F, Cesaroni, G, El Marroun, Hanan, Fernandez-Somoano, A, Freire, C, Hanke, W, Hoek, G, Ibarluzea, J, Iniguez, C, Jansen, Pauline, Lepeule, J, Markevych, I, Polanska, K, Porta, D, Schikowski, T, Slama, R, Standl, M, Tardon, A, Vrijkotte, TG, von Berg, A, Tiemeier, Henning, Sunyer, J, and Guxens Junyent, Monica

Published
2019

5. Associations of Air Pollution on the Brain in Children: A Brain Imaging Study.

Author

Guxens M, Lubczynska MJ, Perez-Crespo L, Muetzel RL, El Marroun H, Basagana X, Hoek G, and Tiemeier H

Subjects
Adolescent, Brain diagnostic imaging, Child, Child, Preschool, Diffusion Tensor Imaging, Female, Humans, Nitrogen Dioxide toxicity, Particulate Matter adverse effects, Pregnancy, Vehicle Emissions analysis, Air Pollutants adverse effects, Air Pollution adverse effects, Prenatal Exposure Delayed Effects epidemiology
Abstract

Introduction: Epidemiological studies are highlighting the negative effects of the exposure to air pollution on children's neurodevelopment. However, most studies assessed children's neurodevelopment using neuropsychological tests or questionnaires. Using magnetic resonance imaging (MRI) to precisely measure global and region-specific brain development would provide details of brain morphology and connectivity. This would help us understand the observed cognitive and behavioral changes related to air pollution exposure. Moreover, most studies assessed only a few air pollutants. This project investigates whether air pollution exposure to many pollutants during pregnancy and childhood is associated with the morphology and connectivity of the brain in school-age children and pre-adolescents., Methods: We used data from the Generation R Study, a population-based birth cohort set up in Rotterdam, the Netherlands in 2002-2006 (n = 9,610). We used land-use regression (LUR) models to estimate the levels of 14 air pollutants at participant's homes during pregnancy and childhood: nitrogen oxides (NO x ), nitrogen dioxide (NO 2 ), particulate matter with aerodynamic diameter ≤10 μm (PM 10 ) or ≤2.5 μm (PM 2.5 ), PM between 10 μm and 2.5 μm (PM COARSE ), absorbance of the PM 2.5 fraction - a measure of soot (PM 2.5 absorbance), the composition of PM 2.5 such as polycyclic aromatic hydrocarbons (PAHs), organic carbon (OC), copper (Cu), iron (Fe), silicon (Si), zinc (Zn), and the oxidative potential of PM 2.5 evaluated using two acellular methods: dithiothreitol (OP DTT ) and electron spin resonance (OP ESR ). We performed MRI measurements of structural morphology (i.e., brain volumes, cortical thickness, and cortical surface area) using T 1 -weighted images in 6- to 10-year-old school-age children and 9- to 12-year-old pre-adolescents, structural connectivity (i.e., white matter microstructure) using diffusion tensor imaging (DTI) in pre-adolescents, and functional connectivity (i.e., connectivity score between brain areas) using resting-state functional MRI (rs-fMRI) in pre-adolescents. We assessed cognitive function using the Developmental Neuropsychological Assessment test (NEPSY-II) in school-age children. For each outcome, we ran regression analysis adjusted for several socioeconomic and lifestyle characteristics. We performed single-pollutant analyses followed by multipollutant analyses using the deletion/substitution/addition (DSA) approach., Results: The project has air pollution and brain MRI data for 783 school-age children and 3,857 pre-adolescents. First, exposure to air pollution during pregnancy or childhood was not associated with global brain volumes (e.g., total brain, cortical gray matter, and cortical white matter) in school-age children or pre-adolescents. However, higher pregnancy or childhood exposure to several air pollutants was associated with a smaller corpus callosum and hippocampus, and a larger amygdala, nucleus accumbens, and cerebellum in pre-adolescents, but not in school-age children. Second, higher exposure to several air pollutants during pregnancy was associated with a thinner cortex in various regions of the brain in both school-age children and pre-adolescents. Higher exposure to air pollution during childhood was also associated with a thinner cortex in a single region in pre-adolescents. A thinner cortex in two regions mediated the association between higher exposure to air pollution during pregnancy and an impaired inhibitory control in school-age children. Third, higher exposure to air pollution during childhood was associated with smaller cortical surface areas in various regions of the brain except in a region where we observed a larger cortical surface area in pre-adolescents. In relation to brain structural connectivity, higher exposure to air pollution during pregnancy and childhood was associated with an alteration in white matter microstructure in pre-adolescents. In relation to brain functional connectivity, a higher exposure to air pollution, mainly during pregnancy and early childhood, was associated with a higher brain functional connectivity among several brain regions in pre-adolescents. Overall, we identified several air pollutants associated with brain structural morphology, structural connectivity, and functional connectivity, such as NO x , NO 2 , PM of various size fractions (i.e., PM 10 , PM COARSE , and PM 2.5 ), PM 2.5 absorbance, PAHs, OC, three elemental components of PM 2.5 (i.e., Cu, Si, Zn), and the oxidative potential of PM 2.5., Conclusions: The results of this project suggest that exposure to air pollution during pregnancy and childhood play an adverse role in brain development. We observed this relationship even at levels of exposure that were below the European Union legislations. We acknowledge that identifying the independent effects of specific pollutants was particularly challenging. Most of our conclusions generally refer to traffic-related air pollutants. However, we did identify pollutants specifically originating from brake linings, tire wear, and tailpipe emissions from diesel combustion. The current direction toward innovative solutions for cleaner energy vehicles is a step in the right direction. However, our findings indicate that these measures might not be completely adequate to mitigate health problems attributable to traffic-related air pollution, as we also observed associations with markers of brake linings and tire wear., (© 2022 Health Effects Institute. All rights reserved.)

Published
2022

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