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1. Effects of tricuspid transcatheter edge-to-edge repair on tricuspid annulus diameter - Data from the TriValve registry

Author

Russo, G, Hahn, R, Alessandrini, H, Andreas, M, Badano, L, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hausleiter, J, Himbert, D, Kalbacher, D, Latib, A, Lubos, E, Ludwig, S, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Praz, F, Rodes-Cabau, J, Rommel, K, Schofer, J, Sievert, H, Tang, G, Thiele, H, Unterhuber, M, von Bardeleben, R, Webb, J, Windecker, S, Leon, M, Maisano, F, Taramasso, M, Russo G., Hahn R. T., Alessandrini H., Andreas M., Badano L. P., Braun D., Connelly K. A., Denti P., Estevez-Loureiro R., Fam N., Gavazzoni M., Hausleiter J., Himbert D., Kalbacher D., Latib A., Lubos E., Ludwig S., Lurz P., Monivas V., Nickenig G., Pedicino D., Pedrazzini G., Pozzoli A., Praz F., Rodes-Cabau J., Rommel K. -P., Schofer J., Sievert H., Tang G., Thiele H., Unterhuber M., von Bardeleben R. S., Webb J., Windecker S., Leon M., Maisano F., Taramasso M., Russo, G, Hahn, R, Alessandrini, H, Andreas, M, Badano, L, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hausleiter, J, Himbert, D, Kalbacher, D, Latib, A, Lubos, E, Ludwig, S, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Praz, F, Rodes-Cabau, J, Rommel, K, Schofer, J, Sievert, H, Tang, G, Thiele, H, Unterhuber, M, von Bardeleben, R, Webb, J, Windecker, S, Leon, M, Maisano, F, Taramasso, M, Russo G., Hahn R. T., Alessandrini H., Andreas M., Badano L. P., Braun D., Connelly K. A., Denti P., Estevez-Loureiro R., Fam N., Gavazzoni M., Hausleiter J., Himbert D., Kalbacher D., Latib A., Lubos E., Ludwig S., Lurz P., Monivas V., Nickenig G., Pedicino D., Pedrazzini G., Pozzoli A., Praz F., Rodes-Cabau J., Rommel K. -P., Schofer J., Sievert H., Tang G., Thiele H., Unterhuber M., von Bardeleben R. S., Webb J., Windecker S., Leon M., Maisano F., and Taramasso M.

Abstract

Aims: T-TEER is an effective therapy for the treatment of tricuspid regurgitation (TR). However, the effects of leaflets clipping on tricuspid valve annulus (TA) have not been investigated in detail. The aim of this study is to investigate the effects of tricuspid transcatheter edge-to-edge repair (T-TEER) on TA diameter. Methods and results: The TriValve registry (Transcatheter Tricuspid Valve Therapies, NCT03416166) collected 556 patients from 22 European and North American centres undergoing transcatheter tricuspid valve interventions from 2016 to 2022. Patients undergoing T-TEER with available pre- and post-procedural data on TA diameter measured in the apical 4-chamber view on transthoracic echocardiography were selected for this study. Primary end-point was the reduction of TA diameter after T-TEER. A total of 186 patients were included in the study. In 115 patients (62%) TA diameter was reduced by at least 1 mm as compared to baseline. A significant reduction of TA dimension was observed following T-TEER (mean 2.3 mm [from pre-procedural diameter 46.7 mm to post-procedural diameter 44.4 mm], p < 0.001). In particular, the greatest reduction was observed in those with T-TEER in antero-septal commissure (mean 2.7 mm [from 47.1 mm to 44.4 mm], p < 0.001) as compared to those combining both antero-septal and postero-septal commissures (mean 1.4, from 46.0 mm to 44.6 mm, P = 0.06). A significant reduction of TA dimension was recorded in patients with 1 or 2 clips implanted but not in those patients with ≥3 clips implanted. Conclusions: In almost two third of patients T-TEER reduces TA diameter in addition to leaflet approximation. Condensed abstract: The effects of tricuspid transcatheter edge-to-edge repair (T-TEER) on tricuspid valve annulus (TA) have not been studied in details. This study investigates TA diameter as measured in apical 4-chamber view on transthoracic echocardiography before and after T-TEER. A total of 186 patients from the TriValve regis

Published
2024

2. Prognostic Implications of Residual Tricuspid Regurgitation Grading After Transcatheter Tricuspid Valve Repair

Author

Dreyfus, J, Taramasso, M, Kresoja, K, Omran, H, Iliadis, C, Russo, G, Weber, M, Nombela-Franco, L, Estevez Loureiro, R, Hausleiter, J, Latib, A, Stolz, L, Praz, F, Windecker, S, Zamorano, J, von Bardeleben, R, Tang, G, Hahn, R, Lubos, E, Webb, J, Schofer, J, Fam, N, Lauten, A, Pedrazzini, G, Rodes-Cabau, J, Nejjari, M, Badano, L, Alessandrini, H, Himbert, D, Sievert, H, Piayda, K, Donal, E, Modine, T, Nickenig, G, Pfister, R, Rudolph, V, Bernick, J, Wells, G, Bax, J, Lurz, P, Enriquez-Sarano, M, Maisano, F, Messika-Zeitoun, D, Ajmone-Marsan, N, Bartko, P, Bazire, B, Benfari, G, Bohbot, Y, Carnero-Alcazar, M, Chan, V, Coisne, A, Crestanello, J, De Bonis, M, Doguet, F, Eggenspieler, F, Eixeres-Esteve, A, Loureiro, R, Eyharts, D, Flagiello, M, Galloo, X, Gavazzoni, M, Habib, G, Heitzinger, G, Iung, B, Juarez-Casso, F, Lavie-Badie, Y, Le Tourneau, T, Lim, P, Mbaki, Y, Michelena, H, Muraru, D, Nicol, M, Obadia, J, Radu, C, El Idrissi, K, Riant, E, Ruf, T, Sala, A, Selton-Suty, C, Senage, T, Tomasi, J, Topilsky, Y, Tribouilloy, C, Viau, F, Dreyfus J., Taramasso M., Kresoja K. -P., Omran H., Iliadis C., Russo G., Weber M., Nombela-Franco L., Estevez Loureiro R., Hausleiter J., Latib A., Stolz L., Praz F., Windecker S., Zamorano J. L., von Bardeleben R. S., Tang G. H. L., Hahn R., Lubos E., Webb J., Schofer J., Fam N., Lauten A., Pedrazzini G., Rodes-Cabau J., Nejjari M., Badano L., Alessandrini H., Himbert D., Sievert H., Piayda K., Donal E., Modine T., Nickenig G., Pfister R., Rudolph V., Bernick J., Wells G. A., Bax J., Lurz P., Enriquez-Sarano M., Maisano F., Messika-Zeitoun D., Ajmone-Marsan N., Bartko P., Bazire B., Benfari G., Bohbot Y., Carnero-Alcazar M., Chan V., Coisne A., Crestanello J., De Bonis M., Doguet F., Eggenspieler F., Eixeres-Esteve A., Loureiro R. E., Eyharts D., Flagiello M., Galloo X., Gavazzoni M., Habib G., Heitzinger G., Iung B., Juarez-Casso F., Lavie-Badie Y., Le Tourneau T., Lim P., Mbaki Y., Michelena H., Muraru D., Nicol M., Obadia J. -F., Radu C., El Idrissi K. R., Riant E., Ruf T., Sala A., Selton-Suty C., Senage T., Tomasi J., Topilsky Y., Tribouilloy C., Viau F., Dreyfus, J, Taramasso, M, Kresoja, K, Omran, H, Iliadis, C, Russo, G, Weber, M, Nombela-Franco, L, Estevez Loureiro, R, Hausleiter, J, Latib, A, Stolz, L, Praz, F, Windecker, S, Zamorano, J, von Bardeleben, R, Tang, G, Hahn, R, Lubos, E, Webb, J, Schofer, J, Fam, N, Lauten, A, Pedrazzini, G, Rodes-Cabau, J, Nejjari, M, Badano, L, Alessandrini, H, Himbert, D, Sievert, H, Piayda, K, Donal, E, Modine, T, Nickenig, G, Pfister, R, Rudolph, V, Bernick, J, Wells, G, Bax, J, Lurz, P, Enriquez-Sarano, M, Maisano, F, Messika-Zeitoun, D, Ajmone-Marsan, N, Bartko, P, Bazire, B, Benfari, G, Bohbot, Y, Carnero-Alcazar, M, Chan, V, Coisne, A, Crestanello, J, De Bonis, M, Doguet, F, Eggenspieler, F, Eixeres-Esteve, A, Loureiro, R, Eyharts, D, Flagiello, M, Galloo, X, Gavazzoni, M, Habib, G, Heitzinger, G, Iung, B, Juarez-Casso, F, Lavie-Badie, Y, Le Tourneau, T, Lim, P, Mbaki, Y, Michelena, H, Muraru, D, Nicol, M, Obadia, J, Radu, C, El Idrissi, K, Riant, E, Ruf, T, Sala, A, Selton-Suty, C, Senage, T, Tomasi, J, Topilsky, Y, Tribouilloy, C, Viau, F, Dreyfus J., Taramasso M., Kresoja K. -P., Omran H., Iliadis C., Russo G., Weber M., Nombela-Franco L., Estevez Loureiro R., Hausleiter J., Latib A., Stolz L., Praz F., Windecker S., Zamorano J. L., von Bardeleben R. S., Tang G. H. L., Hahn R., Lubos E., Webb J., Schofer J., Fam N., Lauten A., Pedrazzini G., Rodes-Cabau J., Nejjari M., Badano L., Alessandrini H., Himbert D., Sievert H., Piayda K., Donal E., Modine T., Nickenig G., Pfister R., Rudolph V., Bernick J., Wells G. A., Bax J., Lurz P., Enriquez-Sarano M., Maisano F., Messika-Zeitoun D., Ajmone-Marsan N., Bartko P., Bazire B., Benfari G., Bohbot Y., Carnero-Alcazar M., Chan V., Coisne A., Crestanello J., De Bonis M., Doguet F., Eggenspieler F., Eixeres-Esteve A., Loureiro R. E., Eyharts D., Flagiello M., Galloo X., Gavazzoni M., Habib G., Heitzinger G., Iung B., Juarez-Casso F., Lavie-Badie Y., Le Tourneau T., Lim P., Mbaki Y., Michelena H., Muraru D., Nicol M., Obadia J. -F., Radu C., El Idrissi K. R., Riant E., Ruf T., Sala A., Selton-Suty C., Senage T., Tomasi J., Topilsky Y., Tribouilloy C., and Viau F.

Abstract

Background: The safety profile of transcatheter tricuspid valve (TTV) repair techniques is well established, but residual tricuspid regurgitation (TR) remains a concern. Objectives: The authors sought to assess the impact of residual TR severity post–TTV repair on survival. Methods: We evaluated the survival rate at 2 years of 613 patients with severe isolated functional TR who underwent TTV repair in TRIGISTRY according to the severity of residual TR at discharge using a 3-grade (mild, moderate, and severe) or 4-grade scheme (mild, mild to moderate, moderate to severe, and severe). Results: Residual TR was none/mild in 33%, moderate in 52%, and severe in 15%. The 2-year adjusted survival rates significantly differed between the 3 groups (85%, 70%, and 44%, respectively; restricted mean survival time [RMST]: P = 0.0001). When the 319 patients with moderate residual TR were subdivided into mild to moderate (n = 201, 33%) and moderate to severe (n = 118, 19%), the adjusted survival rate was also significantly different between groups (85%, 80%, 55%, and 44%, respectively; RMST: P = 0.001). Survival was significantly lower in patients with moderate to severe residual TR compared to patients with mild to moderate residual TR (P = 0.006). No difference in survival rates was observed between patients with no/mild and mild to moderate residual TR (P = 0.67) or between patients with moderate to severe and severe residual TR (P = 0.96). Conclusions: The moderate residual TR group was heterogeneous and encompassed patients with markedly different clinical outcomes. Refining TR grade classification with a more granular 4-grade scheme improved outcome prediction. Our results highlight the importance of achieving a mild to moderate or lower residual TR grade during TTV repair, which could define a successful intervention.

Published
2024

3. Prediction of Mortality and Heart Failure Hospitalization After Transcatheter Tricuspid Valve Interventions: Validation of TRISCORE

Author

Adamo, M, Russo, G, Pagnesi, M, Pancaldi, E, Alessandrini, H, Andreas, M, Badano, L, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hahn, R, Harr, C, Hausleiter, J, Himbert, D, Kalbacher, D, Ho, E, Latib, A, Lubos, E, Ludwig, S, Lupi, L, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Marafon, D, Pastorino, R, Praz, F, Rodes-Cabau, J, Besler, C, Schober, A, Schofer, J, Scotti, A, Piayda, K, Sievert, H, Tang, G, Sticchi, A, Messika-Zeitoun, D, Thiele, H, Schlotter, F, von Bardeleben, R, Webb, J, Dreyfus, J, Windecker, S, Leon, M, Maisano, F, Metra, M, Taramasso, M, Adamo M., Russo G., Pagnesi M., Pancaldi E., Alessandrini H., Andreas M., Badano L. P., Braun D., Connelly K. A., Denti P., Estevez-Loureiro R., Fam N., Gavazzoni M., Hahn R. T., Harr C., Hausleiter J., Himbert D., Kalbacher D., Ho E., Latib A., Lubos E., Ludwig S., Lupi L., Lurz P., Monivas V., Nickenig G., Pedicino D., Pedrazzini G., Pozzoli A., Marafon D. P., Pastorino R., Praz F., Rodes-Cabau J., Besler C., Schober A. R., Schofer J., Scotti A., Piayda K., Sievert H., Tang G. H. L., Sticchi A., Messika-Zeitoun D., Thiele H., Schlotter F., von Bardeleben R. S., Webb J., Dreyfus J., Windecker S., Leon M., Maisano F., Metra M., Taramasso M., Adamo, M, Russo, G, Pagnesi, M, Pancaldi, E, Alessandrini, H, Andreas, M, Badano, L, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hahn, R, Harr, C, Hausleiter, J, Himbert, D, Kalbacher, D, Ho, E, Latib, A, Lubos, E, Ludwig, S, Lupi, L, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Marafon, D, Pastorino, R, Praz, F, Rodes-Cabau, J, Besler, C, Schober, A, Schofer, J, Scotti, A, Piayda, K, Sievert, H, Tang, G, Sticchi, A, Messika-Zeitoun, D, Thiele, H, Schlotter, F, von Bardeleben, R, Webb, J, Dreyfus, J, Windecker, S, Leon, M, Maisano, F, Metra, M, Taramasso, M, Adamo M., Russo G., Pagnesi M., Pancaldi E., Alessandrini H., Andreas M., Badano L. P., Braun D., Connelly K. A., Denti P., Estevez-Loureiro R., Fam N., Gavazzoni M., Hahn R. T., Harr C., Hausleiter J., Himbert D., Kalbacher D., Ho E., Latib A., Lubos E., Ludwig S., Lupi L., Lurz P., Monivas V., Nickenig G., Pedicino D., Pedrazzini G., Pozzoli A., Marafon D. P., Pastorino R., Praz F., Rodes-Cabau J., Besler C., Schober A. R., Schofer J., Scotti A., Piayda K., Sievert H., Tang G. H. L., Sticchi A., Messika-Zeitoun D., Thiele H., Schlotter F., von Bardeleben R. S., Webb J., Dreyfus J., Windecker S., Leon M., Maisano F., Metra M., and Taramasso M.

Abstract

Background: Data on the prognostic role of the TRI-SCORE in patients undergoing transcatheter tricuspid valve intervention (TTVI) are limited. Objectives: The aim of this study was to evaluate the performance of the TRI-SCORE in predicting outcomes of patients undergoing TTVI. Methods: TriValve (Transcatheter Tricuspid Valve Therapies) is a large multicenter multinational registry including patients undergoing TTVI. The TRI-SCORE is a risk model recently proposed to predict in-hospital mortality after tricuspid valve surgery. The TriValve population was stratified based on the TRI-SCORE tertiles. The outcomes of interest were all-cause death and all-cause death or heart failure hospitalization. Procedural complications and changes in NYHA functional class were also reported. Results: Among the 634 patients included, 223 patients (35.2%) had a TRI-SCORE between 0 and 5, 221 (34.8%) had 6 or 7, and 190 (30%) had ≥8 points. Postprocedural blood transfusion, acute kidney injury, new atrial fibrillation, and in-hospital mortality were more frequent in the highest TRI-SCORE tertile. Postprocedure length of stay increased with a TRI-SCORE increase. A TRI-SCORE ≥8 was associated with an increased risk of 30-day all-cause mortality and all-cause mortality and the composite endpoint assessed at a median follow-up of 186 days (OR: 3.00; 95% CI: 1.38-6.55; HR: 2.17; 95% CI: 1.78-4.13; HR: 2.08, 95% CI: 1.57-2.74, respectively) even after adjustment for procedural success and EuroSCORE II or Society of Thoracic Surgeons Predicted Risk of Mortality. The NYHA functional class improved across all TRI-SCORE values. Conclusions: In the TriValve registry, the TRI-SCORE has a suboptimal performance in predicting clinical outcomes. However, a TRISCORE ≥8 is associated with an increased risk of clinical events and a lack of prognostic benefit after successful TTVI.

Published
2024

8. Impact of anaemia and iron deficiency on long-term outcomes following transcatheter edge-to-edge repair in degenerative vs. secondary mitral regurgitation: results from a large single-center study

Author

Khurrami, S, primary, Koell, B, additional, Ludwig, S, additional, Pauschinger, C, additional, Weimann, J, additional, Reichenspurner, H, additional, Conradi, L, additional, Schaefer, A, additional, Blankenberg, S, additional, Lubos, E, additional, Schofer, N, additional, and Kalbacher, D, additional

Published
2023
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9. Long- term results of interventional treatment of paravalvular leaks after prosthetic valve replacement with plug devices. Results from a prospective registry

Author

Zahn, R, primary, Kment, H, additional, Werner, N, additional, Ouarrak, T, additional, Blankenberg, S, additional, Schofer, J, additional, Lubos, E, additional, Geist, V, additional, Eggebrecht, H, additional, Butter, C, additional, Schaefer, U, additional, Schumacher, B, additional, and Schneider, S, additional

Published
2023
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12. Characteristics and outcomes of patients with atrial versus ventricular secondary tricuspid regurgitation undergoing tricuspid transcatheter edge-to-edge repair - Results from the TriValve registry

Author

Russo, G, Badano, L, Adamo, M, Alessandrini, H, Andreas, M, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hahn, R, Harr, C, Hausleiter, J, Himbert, D, Kalbacher, D, Ho, E, Latib, A, Lubos, E, Ludwig, S, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Marafon, D, Pastorino, R, Praz, F, Rodes-Cabau, J, Besler, C, Schofer, J, Scotti, A, Piayda, K, Sievert, H, Tang, G, Thiele, H, Schlotter, F, von Bardeleben, R, Webb, J, Windecker, S, Leon, M, Maisano, F, Metra, M, Taramasso, M, Connelly, KA, Hahn, RT, Marafon, DP, Tang, GHL, von Bardeleben, RS, Russo, G, Badano, L, Adamo, M, Alessandrini, H, Andreas, M, Braun, D, Connelly, K, Denti, P, Estevez-Loureiro, R, Fam, N, Gavazzoni, M, Hahn, R, Harr, C, Hausleiter, J, Himbert, D, Kalbacher, D, Ho, E, Latib, A, Lubos, E, Ludwig, S, Lurz, P, Monivas, V, Nickenig, G, Pedicino, D, Pedrazzini, G, Pozzoli, A, Marafon, D, Pastorino, R, Praz, F, Rodes-Cabau, J, Besler, C, Schofer, J, Scotti, A, Piayda, K, Sievert, H, Tang, G, Thiele, H, Schlotter, F, von Bardeleben, R, Webb, J, Windecker, S, Leon, M, Maisano, F, Metra, M, Taramasso, M, Connelly, KA, Hahn, RT, Marafon, DP, Tang, GHL, and von Bardeleben, RS

Abstract

Aim Functional or secondary tricuspid regurgitation (STR) is the most common phenotype of tricuspid regurgitation (TR) with atrial STR (ASTR) and ventricular STR (VSTR) being recently identified as two distinct entities. Data on tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with STR according to phenotype (i.e. ASTR vs. VSTR) are lacking. The aim of this study was to assess characteristics and outcomes of patients with ASTR versus VSTR undergoing T-TEER. Methods and results Patients with STR undergoing T-TEER were selected from the Transcatheter Tricuspid Valve Therapies (TriValve) registry. ASTR was defined by (i) left ventricular ejection fraction >= 50%, (ii) atrial fibrillation, and (iii) systolic pulmonary artery pressure <50 mmHg. Patients not matching these criteria were classified as VSTR. Patients with primary TR and cardiac implantable electronic device were excluded. Key endpoints included procedural success and survival at follow-up. A total of 298 patients were enrolled in the study: 65 (22%) with ASTR and 233 (78%) with VSTR. Procedural success was similar in the two groups (80% vs. 83% for ASTR vs. VSTR, p = 0.56) and TEER was effective in reducing TR in both groups (from 97% of patients with baseline TR >= 3+ to 23% in ASTR and to 15% in VSTR, all p = 0.001). At 12-month follow-up, survival was significantly higher in the ASTR versus VSTR cohort (91% vs. 72%, log-rank p = 0.02), with VSTR being an independent predictor of mortality at multivariable analysis (hazard ratio 4.75). Conclusions In a real-world, multicentre registry, T-TEER was effective in reducing TR grade in both ASTR and VSTR. At 12-month follow-up, ASTR showed better survival than VSTR.

Published
2023

14. Critical evaluation of the MitraClip system in the management of mitral regurgitation

Author

Deuschl F, Schofer N, Lubos E, Blankenberg S, and Schäfer U

Subjects
MitraClip, Mitral Regurgitation, Percutaneous Mitral Valve Repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Florian Deuschl* Niklas Schofer* Edith Lubos, Stefan Blankenberg, Ulrich Schäfer Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany *These authors contributed equally to this work Abstract: The MitraClip (MC) system is a device for percutaneous, transseptal edge-to-edge reconstruction of the mitral valve (MV) in patients with severe mitral regurgitation (MR) not eligible for surgery. Recently, a number of studies have underlined the therapeutic benefit of the MC system for patients with extreme and high risk for MV surgery suffering from either degenerative or functional MR. The MC procedure shows negligible intraprocedural mortality, low periprocedural complication rates, and a significant reduction in MR, as well as an improvement in functional capacity and most importantly quality of life. Presently, the MC system has become an additional interventional tool in the concert of surgical methods. It hereby enlarges the spectrum of MV repair for the Heart Team. Lately, many reviews focused on the MC system. The current review describes the developments in the treatment of MR with the MC system. Keywords: MitraClip, mitral regurgitation, percutaneous mitral valve repair

Published
2016

15. Addendum to the position paper of the German Cardiac Society Interventional treatment of AV valvular diseases-Criteria for certification of mitral valve centers

Author

Baldus, S., Bardeleben, R. S., V, Eggebrecht, H., Elsasser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V, Schulze, P. C., Schlitt, A., Stellbrink, C., Moellmann, H., Baldus, S., Bardeleben, R. S., V, Eggebrecht, H., Elsasser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V, Schulze, P. C., Schlitt, A., Stellbrink, C., and Moellmann, H.

Published
2022

17. Outcomes of patients with severe mitral regurgitation treated with transcatheter mitral valve implantation or medical therapy

Author

Ludwig, S, primary, Sedighian, S, additional, Weimann, J, additional, Koell, B, additional, Waldschmidt, L, additional, Schaefer, A, additional, Seiffert, M, additional, Westermann, D, additional, Reichenspurner, H, additional, Blankenberg, S, additional, Schofer, N, additional, Lubos, E, additional, Conradi, L, additional, and Kalbacher, D, additional

Published
2022
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20. Impact of the cardio-hepatic syndrome on outcomes after transcatheter mitral valve edge-to-edge repair

Author

Stolz, L, primary, Orban, M, additional, Karam, N, additional, Lubos, E, additional, Wild, M, additional, Praz, F, additional, Braun, D, additional, Doldi, P, additional, Tence, N, additional, Hagl, C, additional, Mayerle, J, additional, Naebauer, M, additional, Kalbacher, D, additional, Massberg, S, additional, and Hausleiter, J, additional

Published
2021
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21. Long-Term survival and functional status in patients with elevated mitral valve pressure gradient after transcatheter mitral valve repair

Author

Koell, B, primary, Ludwig, S, additional, Weimann, J, additional, Waldschmidt, L, additional, Schofer, N, additional, Seiffert, M, additional, Schirmer, J, additional, Westermann, D, additional, Reichenspurner, H, additional, Blankenberg, S, additional, Lubos, E, additional, Conradi, L, additional, and Kalbacher, D, additional

Published
2021
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22. Combined Tricuspid and Mitral Versus Isolated Mitral Valve Repair for Severe MR and TR: An Analysis From the TriValve and TRAMI Registries

Author

Mehr M, Karam N, Taramasso M, Ouarrak T, Schneider S, Lurz P, von Bardeleben RS, Fam N, Pozzoli A, Lubos E, Boekstegers P, Schillinger W, Plicht B, Eggebrecht H, Baldus S, Senges J, Maisano F, Hausleiter J, TriValve, Investigators T, Mehr, M, Karam, N, Taramasso, M, Ouarrak, T, Schneider, S, Lurz, P, von Bardeleben, R, Fam, N, Pozzoli, A, Lubos, E, Boekstegers, P, Schillinger, W, Plicht, B, Eggebrecht, H, Baldus, S, Senges, J, Maisano, F, Hausleiter, J, Trivalve, and Investigators, T

Published
2020

32. Interventional treatment of AV valvular diseases-Criteria for certification of mitral valve centers Position paper of the German Cardiac Society

Author

Baldus, S., Bardeleben, R. S., V, Eggebrecht, H., Elsaesser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V, Schulze, P. C., Schlitt, A., Stellbrink, C., Moellmann, H., Baldus, S., Bardeleben, R. S., V, Eggebrecht, H., Elsaesser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V, Schulze, P. C., Schlitt, A., Stellbrink, C., and Moellmann, H.

Abstract

Mitral and tricuspid regurgitation are highly prevalent types of valvular heart disease, important drivers of a poor prognosis and subject to catheter-based treatment. The transcatheter reconstruction of the valves has meanwhile evolved as an important alternative to pure medicinal treatment and surgical interventions. Whereas transcatheter treatment of tricuspid valve insufficiency has recently shown effectiveness and safety in the first registries, transcatheter treatment of mitral valve insufficiency has meanwhile been tested in several randomized trials. This paper comments on the results of these trials and presents recommendations regarding the indications for the interventional treatment modalities available for mitral and tricuspid valve regurgitation. As part of this manuscript and in an effort to further improve the quality of care, the German Cardiac Society has updated the criteria for the certification of centers for transcatheter treatment of mitral valve insufficiency.

Published
2020

33. Interventional treatment of AV valvular diseases-Criteria for certification of mitral valve centers. Position paper of the German Cardiac Society (vol 14, pg 339, 2020)

Author

Baldus, S., V. Bardeleben, R. S., Eggebrecht, H., Elsaesser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V., Schulze, P. C., Schlitt, A., Stellbrink, C., Moellmann, H., Baldus, S., V. Bardeleben, R. S., Eggebrecht, H., Elsaesser, A., Hausleiter, J., Ince, H., Kelm, M., Kuck, K. H., Lubos, E., Nef, H., Raake, P., Rillig, A., Rudolph, V., Schulze, P. C., Schlitt, A., Stellbrink, C., and Moellmann, H.

Published
2020

36. 1000 MitraClip™ procedures

Author

Kalbacher, D, primary, Ludwig, S, additional, Schofer, N, additional, Schirmer, J, additional, Reichenspurner, H, additional, Conradi, L, additional, Blankenberg, S, additional, and Lubos, E, additional

Published
2019
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38. 1385Combined tricuspid and mitral vs. isolated mitral valve repair for severe mitral and tricuspid regurgitation: An analysis from TriValve and TRAMI registries

Author

Mehr, M, primary, Taramasso, M, additional, Ourrak, T, additional, Lurz, P, additional, Von Bardeleben, R S, additional, Fam, N, additional, Lubos, E, additional, Boekstegers, P, additional, Schillinger, W, additional, Plicht, B, additional, Eggebrecht, H, additional, Baldus, S, additional, Senges, J, additional, Maisano, F, additional, and Hausleiter, J, additional

Published
2019
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39. P4730Underweight is associated with unfavourable short- and long-term outcomes after MitraClip therapy: a body mass index derived subgroup analysis of the German Transcatheter Mitral Valve Interventions (

Author

Kalbacher, D, primary, Tigges, E P, additional, Boekstegers, P, additional, Puls, M, additional, Plicht, B, additional, Eggebrecht, H, additional, Nickenig, G, additional, Von Bardeleben, R S, additional, Zuern, C S, additional, Franke, J, additional, Sievert, H, additional, Ouarrak, T, additional, Senges, J, additional, and Lubos, E, additional

Published
2019
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44. P6031Prevalence and prognostic impact of prosthesis-patient mismatch after transcatheter aortic valve implantation

Author

Schofer, N, primary, Deuschl, F D, additional, Ruebsamen, N R, additional, Seiffert, M S, additional, Voigtlaender, L V, additional, Schaefer, A S, additional, Schneeberger, Y S, additional, Schirmer, J S, additional, Lubos, E L, additional, Reichenspurner, H R, additional, Blankenberg, S B, additional, Conradi, L C, additional, and Schaefer, U S, additional

Published
2018
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49. Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure

Author

Huenlich, M., Lubos, E., Beuthner, B. E., Puls, M., Bleckmann, A., Beissbarth, T., Tichelbaecker, T., Rudolph, V., Baldus, S., Schaefer, U., Treede, H., Von Bardeleben, R. S., Blankenberg, S., Schillinger, W., Huenlich, M., Lubos, E., Beuthner, B. E., Puls, M., Bleckmann, A., Beissbarth, T., Tichelbaecker, T., Rudolph, V., Baldus, S., Schaefer, U., Treede, H., Von Bardeleben, R. S., Blankenberg, S., and Schillinger, W.

Abstract

Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hypertension, and right heart failure as a result of left heart disease were treated in the heart centers Hamburg and Gottingen. Immediately after successful MitraClip implantation, a reduction of the RVOT diameter from 3.52 cm to 3.44 cm was observed reaching a statistically significant value of 3.39 cm after 12 months. In contrast, there was a significant reduction in the velocity of the tricuspid regurgitation (TR) from 4.17 m/s to 3.11 m/s, the gradient of the TR from 48.5 mmHg to 39.3 mmHg, and the systolic pulmonary artery pressure (PAPsyst) from 58.6 mmHg to 50.0 mmHg. This decline continued in the following months (V-max TR 3.09 m/s, peak TR 38.6 mmHg, and PAPsyst 47.4 mmHg). The tricuspid annular plane systolic excursion (TAPSE) increased from 16.5 mm to 18.9 mm after 12 months. MitraClip implantation improves pulmonary artery pressure, tricuspid regurgitation, and TAPSE after 12 months. At the same time, there is a decrease in the RVOT diameter without significant changes in other right ventricular and right atrial dimensions.

Published
2018

50. Long-term follow-up in the German TRAnscatheter mitral valve Interventions (TRAMI) registry: survival and predictors of mortality

Author

Kalbacher, D., Schaefer, U., Von Bardeleben, R. S., Eggebrecht, H., Sievert, H., Nickenig, G., Butter, C., Ouarrak, T., Zahn, R., Baldus, S., Ince, H., Schillinger, W., Boekstegers, P., Senges, J., Lubos, E., Kalbacher, D., Schaefer, U., Von Bardeleben, R. S., Eggebrecht, H., Sievert, H., Nickenig, G., Butter, C., Ouarrak, T., Zahn, R., Baldus, S., Ince, H., Schillinger, W., Boekstegers, P., Senges, J., and Lubos, E.

Published
2018

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