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1. Hematopoietic Stem/Progenitor Cells and Engineering: LONG-TERM DATA ON IMMUNE MONITORING OF CHILDREN GIVEN TCRαβ/CD19 CELL DEPLETED HLA-HAPLOIDENTICAL STEM TRANSPLANTATION (HAPLO-HSCT)

Author

Bertaina, V., primary, Sborgia, R., additional, Marini, O., additional, De Luca, C., additional, Carta, R., additional, Becilli, M., additional, Pagliara, D., additional, Quagliarella, F., additional, Lucarelli, B., additional, Boccieri, E., additional, Velardi, E., additional, Algeri, M., additional, Merli, P., additional, Galaverna, F., additional, and Locatelli, F., additional

Published
2023
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5. RESULTS OF HLA-HAPLOIDENTICAL STEM CELL TRANSPLANTATION AFTER REMOVAL OF ALPHA/BETA+ T CELLS AND OF CD19+ B CELLS IN CHILDREN WITH ACUTE LEUKEMIA: PH-O106

Author

Bertaina, A., Pagliara, D., Pende, D., Rutella, S., Falco, Emma M., Bauquet, A., Spagnoli, A., Lucarelli, B., Brescia, Pomponia L., Merli, P., Andreani, M., Pira, G. Li, Ceccarelli, S., Grapulin, L., Palumbo, G., Bernardo, M. E., Biagini, S., Moretta, F., Milano, Maria G., Airoldi, I., Moretta, A., Moretta, L., and Locatelli, F.

Published
2014

7. The East Asian financial meltdown

Author

Lucarelli, B.

Subjects
International economic relations -- Analysis, Monetary policy -- Analysis, East Asia -- Statistics, East Asia -- Economic aspects
Published
2002

13. T-cell depleted HLA-haploidentical HSCT in a child with neuromyelitis optica

Author

Ceglie, G., Papetti, L., Figa Talamanca, L., Lucarelli, B., Algeri, M., Gaspari, S., Li Pira, G., Colafati, G. -S., Montanari, M., Valeriani, M., Locatelli, Franco, Merli, P., Locatelli F. (ORCID:0000-0002-7976-3654), Ceglie, G., Papetti, L., Figa Talamanca, L., Lucarelli, B., Algeri, M., Gaspari, S., Li Pira, G., Colafati, G. -S., Montanari, M., Valeriani, M., Locatelli, Franco, Merli, P., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Neuromyelitis optica is an immune-mediated disease characterized by a relapsing course, resulting in progressive disability. In children, given the long life expectancy, a disease-modifying treatment could be particularly desirable. Unfortunately, the currently available treatment strategies with this potential are scarce. Very limited data are available about the use of allogeneic hematopoietic stem cell transplantation (HSCT) for autoimmune neurological diseases. In this report, we present a pediatric case successfully treated with allogeneic HSCT from an HLA-haploidentical donor, after ex vivo TCR/CD19-depletion of the graft. To the best of our knowledge, this is the first case of a pediatric patient to benefit from such a treatment.

Published
2019

14. Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

Author

Barzaghi, F., Hernandez, L.C.A., Neven, B., Ricci, S., Kucuk, Z.Y., Bleesing, J.J., Nademi, Z., Slatter, M.A., Ulloa, E.R., Shcherbina, A., Roppelt, A., Worth, A., Silva, J., Aiuti, A., Murguia-Favela, L., Speckmann, C., Carneiro-Sampaio, M., Fernandes, J.F., Baris, S., Ozen, A., Karakoc-Aydiner, E., Kiykim, A., Schulz, A., Steinmann, S., Notarangelo, L.D., Gambineri, E., Lionetti, P., Shearer, W.T., Forbes, L.R., Martinez, C., Moshous, D., Blanche, S., Fisher, A., Ruemmele, F.M., Tissandier, C., Ouachee-Chardin, M., Rieux-Laucat, F., Cavazzana, M., Qasim, W., Lucarelli, B., Albert, M.H., Kobayashi, I., Alonso, L., Heredia, C.D. de, Kanegane, H., Lawitschka, A., Seo, J.J., Gonzalez-Vicent, M., Diaz, M.A., Goyal, R.K., Sauer, M.G., Yesilipek, A., Kim, M., Yilmaz-Demirdag, Y., Bhatia, M., Khlevner, J., Padilla, E.J.R., Martino, S., Montin, D., Neth, O., Molinos-Quintana, A., Valverde-Fernandez, J., Broides, A., Pinsk, V., Ballauf, A., Haerynck, F., Bordon, V., Dhooge, C., Garcia-Lloret, M.L., Bredius, R.G., Kawak, K., Haddad, E., Seidel, M.G., Duckers, G., Pai, S.Y., Dvorak, C.C., Ehl, S., Locatelli, F., Goldman, F., Gennery, A.R., Cowan, M.J., Roncarolo, M.G., Bacchetta, R., PIDTC, IEWP, European Soc Blood Marrow, Barzaghi, Federica, Hernandez, Laura Cristina Amaya, Neven, Benedicte, Ricci, Silvia, Kucuk, Zeynep Yesim, Bleesing, Jack J., Nademi, Zohreh, Slatter, Mary Anne, Ulloa, Erlinda Rose, Shcherbina, Anna, Roppelt, Anna, Worth, Austen, Silva, Juliana, Aiuti, Alessandro, Murguia-Favela, Luis, Speckmann, Carsten, Carneiro-Sampaio, Magda, Fernandes, Juliana Folloni, Baris, Safa, Ozen, Ahmet, Karakoc-Aydiner, Elif, Kiykim, Ayca, Schulz, Ansgar, Steinmann, Sandra, Notarangelo, Lucia Dora, Gambineri, Eleonora, Lionetti, Paolo, Shearer, William Thomas, Forbes, Lisa R., Martinez, Caridad, Moshous, Despina, Blanche, Stephane, Fisher, Alain, Ruemmele, Frank M., Tissandier, Come, Ouachee-Chardin, Marie, Rieux-Laucat, Frederic, Cavazzana, Marina, Qasim, Waseem, Lucarelli, Barbarella, Albert, Michael H., Kobayashi, Ichiro, Alonso, Laura, De Heredia, Cristina Diaz, Kanegane, Hirokazu, Lawitschka, Anita, Seo, Jong Jin, Gonzalez-Vicent, Marta, Diaz, Miguel Angel, Goyal, Rakesh Kumar, Sauer, Martin G., Yesilipek, Akif, Kim, Minsoo, Yilmaz-Demirdag, Yesim, Bhatia, Monica, Khlevner, Julie, Padilla, Erick J. Richmond, Martino, Silvana, Montin, Davide, Neth, Olaf, Molinos-Quintana, Agueda, Valverde-Fernandez, Justo, Broides, Arnon, Pinsk, Vered, Ballauf, Antje, Haerynck, Filomeen, Bordon, Victoria, Dhooge, Catharina, Garcia-Lloret, Maria Laura, Bredius, Robbert G., Kalwak, Krzysztof, Haddad, Elie, Seidel, Markus Gerhard, Duckers, Gregor, Pai, Sung-Yun, Dvorak, Christopher C., Ehl, Stephan, Locatelli, Franco, Goldman, Frederick, Gennery, Andrew Richard, Cowan, Mort J., Roncarolo, Maria-Grazia, Bacchetta, Rosa, Amaya Hernandez, Laura Cristina, Murguia-Favela, Lui, Shearer, William Thoma, Rieux-Laucat, Frédéric, Diaz De Heredia, Cristina, Richmond Padilla, Erick J., and Kałwak, Krzysztof

Subjects
0301 basic medicine, Male, Allergy, medicine.medical_treatment, Medizin, Disease, Hematopoietic stem cell transplantation, SIROLIMUS, Regenerative Medicine, primary immune deficiency, Medicine and Health Sciences, IPEX, Immunology and Allergy, 2.1 Biological and endogenous factors, Enteropathy, Aetiology, POLYENDOCRINOPATHY, Child, Pediatric, CÉLULAS-TRONCO, immunosuppression, Hematopoietic Stem Cell Transplantation, Genetic Diseases, X-Linked, Immunosuppression, Forkhead Transcription Factors, X-LINKED SYNDROME, Allografts, Survival Rate, surgical procedures, operative, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Immune System Diseases, Genetic Diseases, Child, Preschool, hematopoietic stem cell transplantation, Female, hematopoietic stem, neonatal diabetes, FOXP3, Primary Immune Deficiency, Treg cells, enteropathy, genetic autoimmunity, rapamycin, Type 1, Diarrhea, Adult, medicine.medical_specialty, Adolescent, Immunology, Neonatal onset, Article, Disease-Free Survival, 03 medical and health sciences, Neonatal diabete, Clinical Research, Internal medicine, IMMUNODYSREGULATION, medicine, Primary Immune Deficiency Treatment Consortium (PIDTC) and the Inborn Errors Working Party (IEWP) of the European Society for Blood and Marrow Transplantation, Diabetes Mellitus, Genetics, Humans, REGULATORY T-CELLS, cell transplantation, Preschool, Retrospective Studies, Immunosuppression Therapy, Transplantation, IMMUNE DYSREGULATION, business.industry, MUTATIONS, Infant, Retrospective cohort study, STEM-CELL TRANSPLANTATION, IPEX syndrome, X-Linked, medicine.disease, Stem Cell Research, BONE-MARROW-TRANSPLANTATION, Treg cell, FOXP3 MUTATIONS, Diabetes Mellitus, Type 1, 030104 developmental biology, ENGRAFTMENT, Mutation, business, Follow-Up Studies
Abstract

Background Immunodysregulation polyendocrinopathy enteropathy x-linked(IPEX) syndromeis a monogenic autoimmune disease caused by FOXP3 mutations. Because it is a rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) and immunosuppression (IS), have not been thoroughly examined. Objective This analysis sought to evaluate disease onset, progression, and long-term outcome of the 2 main treatments in long-term IPEX survivors. Methods Clinical histories of 96 patients with a genetically proven IPEX syndrome were collected from 38 institutions worldwide and retrospectively analyzed. To investigate possible factors suitable to predict the outcome, an organ involvement (OI) scoring system was developed. Results We confirm neonatal onset with enteropathy, type 1 diabetes, and eczema. In addition, we found less common manifestations in delayed onset patients or during disease evolution. There is no correlation between the site of mutation and the disease course or outcome, and the same genotype can present with variable phenotypes. HSCT patients (n = 58) had a median follow-up of 2.7 years (range, 1 week-15 years). Patients receiving chronic IS (n = 34) had a median follow-up of 4 years (range, 2 months-25 years). The overall survival after HSCT was 73.2% (95% CI, 59.4-83.0) and after IS was 65.1% (95% CI, 62.8-95.8). The pretreatment OI score was the only significant predictor of overall survival after transplant (P = .035) but not under IS. Conclusions Patients receiving chronic IS were hampered by disease recurrence or complications, impacting long-term disease-free survival. When performed in patients with a low OI score, HSCT resulted in disease resolution with better quality of life, independent of age, donor source, or conditioning regimen., GRAPHICAL ABSTRACT

Published
2018

15. A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia

Author

Torraco, A, Bianchi, M, Verrigni, D, Gelmetti, V, Riley, L, Niceta, M, Martinelli, D, Montanari, A, Guo, Y, Rizza, T, Diodato, D, Di Nottia, M, Lucarelli, B, Sorrentino, F, Piemonte, F, Francisci, S, Tartaglia, M, Valente, EM, Dionisi-Vici, C, Christodoulou, J, Bertini, E, Carrozzo, R, Torraco, A, Bianchi, M, Verrigni, D, Gelmetti, V, Riley, L, Niceta, M, Martinelli, D, Montanari, A, Guo, Y, Rizza, T, Diodato, D, Di Nottia, M, Lucarelli, B, Sorrentino, F, Piemonte, F, Francisci, S, Tartaglia, M, Valente, EM, Dionisi-Vici, C, Christodoulou, J, Bertini, E, and Carrozzo, R

Abstract

NDUFB11, a component of mitochondrial complex I, is a relatively small integral membrane protein, belonging to the "supernumerary" group of subunits, but proved to be absolutely essential for the assembly of an active complex I. Mutations in the X-linked nuclear-encoded NDUFB11 gene have recently been discovered in association with two distinct phenotypes, i.e. microphthalmia with linear skin defects and histiocytoid cardiomyopathy. We report on a male with complex I deficiency, caused by a de novo mutation in NDUFB11 and displaying early-onset sideroblastic anemia as the unique feature. This is the third report that describes a mutation in NDUFB11, but all are associated with a different phenotype. Our results further expand the molecular spectrum and associated clinical phenotype of NDUFB11 defects.

Published
2017

16. Outcome of children with acute leukemia given HLA-haploidentical HSCT after ab T-cell and B-cell depletion

Author

Locatelli, Franco, Merli, P., Pagliara, D., Li Pira, G., Falco, M., Pende, D., Rondelli, R., Lucarelli, B., Brescia, L. P., Masetti, R., Milano, G. M., Bertaina, V., Algeri, M., Pinto, R. M., Strocchio, L., Meazza, R., Grapulin, L., Handgretinger, R., Moretta, A., Bertaina, A., Moretta, L., Locatelli F. (ORCID:0000-0002-7976-3654), Locatelli, Franco, Merli, P., Pagliara, D., Li Pira, G., Falco, M., Pende, D., Rondelli, R., Lucarelli, B., Brescia, L. P., Masetti, R., Milano, G. M., Bertaina, V., Algeri, M., Pinto, R. M., Strocchio, L., Meazza, R., Grapulin, L., Handgretinger, R., Moretta, A., Bertaina, A., Moretta, L., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-haploidentical relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either relapsed or at high-risk of treatment failure. We developed a novel method of graft manipulation based on negative depletion of ab T and B cells and conducted a prospective trial evaluating the outcome of children with AL transplanted with this approach. Eighty AL children, transplanted between September 2011 and September 2014, were enrolled in the trial. All children were given a fully myeloablative preparative regimen. Anti–T-lymphocyte globulin from day 25 to 23 was used for preventing graft rejection and graft-versus-host disease (GVHD); no patient received any posttransplantation GVHD prophylaxis. Two children experienced primary graft failure. The cumulative incidence of skin-only, grade 1-2 acute GVHD was 30%; no patient developed extensive chronic GVHD. Four patients died, the cumulative incidence of nonrelapse mortality being 5%, whereas 19 relapsed, resulting in a 24% cumulative incidence of relapse. With a median follow-up of 46 months for surviving patients, the 5-year probability of chronic GVHD-free, relapse-free survival (GRFS) is 71%. Total body irradiation–containing preparative regimen was the only variable favorably influencing relapse incidence and GRFS. The outcomes of these 80 patients are comparable to those of 41 and 51 children given transplantation from an HLA-identical sibling or a 10/10 allelic-matched unrelated donor in the same period. These data indicate that haplo-HSCT after ab T- and B-cell depletion represents a competitive alternative for children with AL in need of urgent allograft. This trial was registered at www.clinicaltrials.gov as #NCT01810120.

Published
2017

17. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy

Author

Girmenia, C, Rossolini, Gm, Piciocchi, A, Bertaina, A, Pisapia, G, Pastore, D, Sica, S, Severino, A, Cudillo, L, Ciceri, F, Scimè, R, Lombardini, L, Viscoli, C, Rambaldi, A, the Gruppo Italiano Trapianto Midollo Osseo (GITMO), Frigeni, M, Corti, C, Mometto, G, Annaloro, C, Casari, E, Castagna, L, Rossi, G, Cattaneo, C, Russo, D, Cancelli, V, Alessandrino, Ep, Ripamonti, F, Pavan, F, Rovelli, A, Pecoraro, C, Busca, A, Carraro, F, Fagioli, F, Gallo, S, Caravelli, D, De Gobbi, M, Saglio, G, Castellino, C, Mordini, N, Gaidano, G, Nassi, L, Raimondi, R, Vespignani, M, Scattolin, Am, Panizzolo, Is, Cesaro, S, Candoni, A, Patriarca, F, Bacigalupo, A, Raiola, A, Castagnola, E, Lanino, E, Stanzani, M, Bandini, G, Massaccesi, E, Prete, A, Bassi, S, Vallisa, D, Caramatti, C, Aversa, F, Zuffa, E, Guidi, S, Bosi, A, Tintori, V, Iori, Ap, Capria, S, Arcese, W, Dentamaro, T, Fabritiis, Pd, Anaclerico, B, Chierichini, A, Piedimonte, M, Ferrari, A, Marchesi, F, Mengarelli, A, Cerchiara, E, Tirindelli, Mc, Gaziev, J, Majolino, I, Chiusolo, P, Lucarelli, B, Massei, Ms, Carotti, A, Perruccio, K, Caniglia, M, Santarone, S, Bartolomeo, Pd, Mazzotta, S, Galieni, P, Olivieri, A, Rosa, Gd, Risitano, A, Delia, M, Specchia, G, Palazzo, G, Messina, G, Irrera, G, Angelucci, E, Baronciani, D, Vacca, A, Crescimanno, A, Musso, M, Imbriani, A, Milone, G., Girmenia, C, Rossolini, Gm, Piciocchi, A, Bertaina, A, Pisapia, G, Pastore, D, Sica, S, Severino, A, Cudillo, L, Ciceri, Fabio, Scime, R, Lombardini, L, Viscoli, C, Rambaldi, A, and and the Gruppo Italiano Trapianto Midollo Osseo, (GITMO)

Subjects
Male, Klebsiella pneumoniae, Carbapenem resistant Klebsiella pneumoniae, Drug Resistance, carbapenem-resistant Klebsiella pneumoniae, colonization, sepsis, Allogeneic Hematopoietic Stem Cell Transplantation, Hematologic Diseases, hemic and lymphatic diseases, polycyclic compounds, Medicine, Adolescent, Adult, Aged, Allografts, Autografts, Female, Humans, Italy, Klebsiella Infections, Middle Aged, Retrospective Studies, Carbapenems, Drug Resistance, Bacterial, Stem Cell Transplantation, Hematology, Transplantation, biology, Bacterial, humanities, surgical procedures, operative, medicine.medical_specialty, Retrospective survey, Internal medicine, business.industry, Retrospective cohort study, Klebsiella infections, biology.organism_classification, Settore MED/15, infection, body regions, Settore MED/15 - MALATTIE DEL SANGUE, Immunology, business
Abstract

Infections by carbapenem-resistant Klebsiella pneumoniae (CRKp) represent a challenging problem after SCT. A retrospective survey (January 2010 to July 2013) involving 52 Italian centers was performed to assess the epidemiology and the prognostic factors of CRKp infections in auto- and allo-SCT. Cases of CRKp infection were reported in 53.4% of centers. CRKp infections were documented in 25 auto-SCTs and 87 allo-SCTs, with an incidence of 0.4% (from 0.1% in 2010 to 0.7% in 2013) and 2% (from 0.4% in 2010 to 2.9% in 2013), respectively. A CRKp colonization documented before or after transplant was followed by an infection in 25.8% of auto-SCT and 39.2% of allo-SCT patients. The infection-related mortality rates were 16% and 64.4%, respectively. A pre-transplant CRKp infection (hazard ratio (HR) 0.33, 95% confidence intervals (CIs) 0.15-0.74; P = 0.007) and a not CRKp-targeted first-line treatment (HR 2.67, 95% CI 1.43-4.99; P = 0.002) were independent factors associated with an increased mortality in allo-SCT patients who developed a CRKp infection. Our study shows challenging findings of CRKp infections in SCT patients in Italy particularly after allo-SCT. The detection of carriers and the definition of early therapeutic strategies represent critical aspects of the management of CRKp infections after SCT. OI Aversa, Franco/0000-0002-8871-6817; de Fabritiis, Paolo/0000-0002-1835-0581; TIRINDELLI, MARIA CRISTINA/0000-0003-4645-4465; cudillo, laura/0000-0002-6828-9707

Published
2015

18. The generation of human innate lymphoid cells is influenced by the source of hematopoietic stem cells and by the use of G-CSF

Author

Moretta, F., Petronelli, F., Lucarelli, B., Pitisci, A., Bertaina, A., Locatelli, Franco, Mingari, M. C., Moretta, L., Montaldo, E., Locatelli F. (ORCID:0000-0002-7976-3654), Moretta, F., Petronelli, F., Lucarelli, B., Pitisci, A., Bertaina, A., Locatelli, Franco, Mingari, M. C., Moretta, L., Montaldo, E., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

NK cells play a central role in the haploidentical HSC transplantation (HSCT) to cure high-risk leukemias. Other innate lymphoid cells (ILCs) have been proposed to exert a protective role in graft-versus-host disease and could also contribute to anti-microbial defence and to lymphoid tissue remodeling. Thus, we investigated the ILC differentiation potential of HSCs isolated from BM, mobilized peripheral blood (PB), and umbilical cord blood (UCB). BM CD34+ cells are enriched in lymphoid-committed precursors, while PB CD34+ cells preferentially contain myeloid precursors. In vitro differentiation experiments revealed that the highest and the lowest CD56+CD161+ ILC recovery was detected in UCB and PB HSC cultures, respectively. Among CD56+CD161+ ILCs, the ratio between NK cells and ILC3s was similar for all HSC analyzed. ILC recovery in PB CD34+ cultures was lower for G-CSF-mobilized HSCs (good mobilizers) than for G-CSF+plerixafor-mobilized HSC (poor mobilizers). Moreover, G-CSF inhibited in vitro ILC recovery and the degree of inhibition was proportional to the time of exposure to the cytokine. Thus, although all common sources of HSC for transplant differentiate towards ILCs, substantial differences exist among different sources and G-CSF may influence ILC recovery. These data offer new clues for a better understanding of the immune reconstitution after HSCT.

Published
2016

19. Strategies to accelerate immune recovery after allogeneic hematopoietic stem cell transplantation

Author

Lucarelli, B., Merli, P., Bertaina, V., Locatelli, Franco, Locatelli F. (ORCID:0000-0002-7976-3654), Lucarelli, B., Merli, P., Bertaina, V., Locatelli, Franco, and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

The interplay existing between immune reconstitution and patient outcome has been extensively demonstrated in allogeneic hematopoietic stem cell transplantation. One of the leading causes of infection-related mortality is the slow recovery of T-cell immunity due to the conditioning regimen and/or age-related thymus damage, poor naïve T-cell output, and restricted T-cell receptor (TCR) repertoires. With the aim of improving posttransplantation immune reconstitution, several immunotherapy approaches have been explored. Donor leukocyte infusions are widely used to accelerate immune recovery, but they carry the risk of provoking graft-versus-host disease. This review will focus on sophisticated strategies of thymus function-recovery, adoptive infusion of donor-derived, allodepleted T cells, T-cell lines/clones specific for life-threatening pathogens, regulatory T cells, and of T cells transduced with suicide genes.

Published
2016

20. Tr1 cells in allogeneic transplantations

Author

Bachetta R, Gregori S, Lucarelli B, BATTAGLIA, MARCO MARIA, Ciceri F, Roncarolo MG, Bachetta, R, Gregori, S, Lucarelli, B, Battaglia, MARCO MARIA, Ciceri, F, and Roncarolo, Mg

Published
2011

21. Interleukin-10 Anergized Donor T Cell Infusion Improves Immune Reconstitution without Severe Graft-Versus-Host-Disease After Haploidentical Hematopoietic Stem Cell Transplantation

Author

Bacchetta R, Sartirana C, Lucarelli B, Miqueu P, Stanghellini MTL, Greco R, Velardi A, Aversa F, Martelli MF, Gregori S, Zappone E, Fleischhauer K, Bernardi M, Peccatori J, Roncarolo MG, CICERI , FABIO, Bacchetta, R, Sartirana, C, Lucarelli, B, Miqueu, P, Stanghellini, Mtl, Greco, R, Velardi, A, Aversa, F, Martelli, Mf, Gregori, S, Zappone, E, Fleischhauer, K, Bernardi, M, Peccatori, J, Ciceri, Fabio, and Roncarolo, Mg

Published
2009

22. A novel mutation inNDUFB11unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia

Author

Torraco, A., primary, Bianchi, M., additional, Verrigni, D., additional, Gelmetti, V., additional, Riley, L., additional, Niceta, M., additional, Martinelli, D., additional, Montanari, A., additional, Guo, Y., additional, Rizza, T., additional, Diodato, D., additional, Di Nottia, M., additional, Lucarelli, B., additional, Sorrentino, F., additional, Piemonte, F., additional, Francisci, S., additional, Tartaglia, M., additional, Valente, E.M., additional, Dionisi‐Vici, C., additional, Christodoulou, J., additional, Bertini, E., additional, and Carrozzo, R., additional

Published
2016
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23. T Cell Immunotherapy for Immune Reconstitution and GVHD Prevention After Allogeneic Hematopoietic Stem Cell Transplantation

Author

Lucarelli, B., Merli, P., Strocchio, L., Cefalo, M. G., Brescia, L. P., Locatelli, Franco, Locatelli F. (ORCID:0000-0002-7976-3654), Lucarelli, B., Merli, P., Strocchio, L., Cefalo, M. G., Brescia, L. P., Locatelli, Franco, and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Many different studies have demonstrated that early recovery of the adaptive immune system after allogeneic hematopoietic stem cell transplantation (HSCT) is predominantly sustained by peripheral expansion of donor-derived, mature lymphocytes transferred with the graft. Different approaches based on the infusion of donor T cells after HSCT have been developed mainly to accelerate immune recovery and to treat/prevent (a) malignancy recurrence, (b) life-threatening infections, and (c) immune-mediated disorders, such as graft-versus-host disease (GVHD). For many years, donor lymphocyte infusion (DLI) has been a widely used approach to prevent and to treat leukemia recurrence, to convert mixed chimerism into complete donor chimerism, and to accelerate immune reconstitution of patients after HSCT. More sophisticated strategies of adoptive infusion of T cell lines/clones capable of mediating a graft-versus-leukemia (GVL) response, while avoiding GVHD occurrence, or specific for the most life-threatening pathogens (e.g., cytomegalovirus, Epstein-Barr virus, and adenovirus) have been envisaged and successfully tested in pilot trials in the early post-transplantation period. Also, ex vivo expanded regulatory T (Treg) cells have been shown to be beneficial for preventing GVHD post-HSCT. In this review, we will focus on DLI as well as more complex cellular therapies that require extensive cell manipulation.

Published
2015

24. Money and Keynesian Uncertainty

Author

Lucarelli, B.

Subjects
uncertainty, money, liquidity preference, crisis, investment, jel:B50, jel:B31, jel:A10, jel:B10, jel:A20, jel:D53, jel:B22
Abstract

Keynes’s theory of a monetary economy and his liquidity preference theory of investment will be examined in order to highlight the essential properties of money under the conditions of uncertainty, which inevitably prefigures the existence of involuntary unemployment and could – within a laissez faire, deregulated financial system – induce phases of endemic financial instability and crises.

Published
2010

35. Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO study

Author

Alessandrino, E. P., primary, Porta, M. G. D., additional, Bacigalupo, A., additional, Malcovati, L., additional, Angelucci, E., additional, Van Lint, M. T., additional, Falda, M., additional, Onida, F., additional, Bernardi, M., additional, Guidi, S., additional, Lucarelli, B., additional, Rambaldi, A., additional, Cerretti, R., additional, Marenco, P., additional, Pioltelli, P., additional, Pascutto, C., additional, Oneto, R., additional, Pirolini, L., additional, Fanin, R., additional, and Bosi, A., additional

Published
2009
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37. Unrelated cord blood transplant in children with high-risk acute lymphoblastic leukemia: a long-term follow-up

Author

Iori, A. P., primary, Arcese, W., additional, Milano, F., additional, Calabrese, E., additional, Torelli, G. F., additional, Barberi, W., additional, Mascolo, M. G., additional, De Felice, L., additional, Screnci, M., additional, Lucarelli, B., additional, Malandruccolo, L., additional, Perrone, M. P., additional, Salvatori, S., additional, Laurenti, L., additional, Iannella, E., additional, Ricci, R., additional, Moleti, M. L., additional, and Foa, R., additional

Published
2007
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41. Distributed Energy Systems in California's Future: A Preliminary Report Volume 2

Author

Balderston, F., primary, Blatman, P., additional, Bradshaw, T., additional, Brown, P., additional, Carroll, O., additional, Christensen, M., additional, Craig, P., additional, Finnegan, S., additional, Glassey, R., additional, Greene, B., additional, Groth, A., additional, Gruener, G., additional, Holdren, J., additional, Horovitz, M., additional, Hoos, I., additional, Kahn, E., additional, Kanin, J., additional, Klein, W., additional, LaPorte, T., additional, Lucarelli, B., additional, McGuire, B., additional, Mintzer, I., additional, Moyer, G., additional, Nader, L., additional, Nathans, R., additional, Palacio, J., additional, Pollock, P., additional, Rich, C., additional, Rochlin, G., additional, Rosow, G., additional, Rubin, B., additional, Schutz, H., additional, Simmons, M., additional, Smith, P., additional, Tourinho, O., additional, Twiss, R., additional, Vine, E., additional, and Wilson, N., additional

Published
1977
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47. Surgical site infection after caesarean section: Space for post-discharge surveillance improvements and reliable comparisons

Author

Ferraro, Federica, Pierluca Piselli, Pittalis, Silvia, Ruscitti, Luca E., Cimaglia, Claudia, Ippolito, Giuseppe, Puro, Vincenzo, Centro di Riferimento per le Infezioni associate alle Pratiche Assistenziali Latium Region Group, Allocca, A., Conti, E., Marzuillo, C., Villari, P., Vullo, V., Zaino, P., Fioriello, C., Farino, F., Orazi, D., Mondillo, V., Baccaro, G., Pignataro, R., Fiore, R., Primave, A., Verginelli, F., Raponi, R., Renda, V., Barboni, P., Belvisi, V., Colazingari, G., Del Bargo, C., Mastroianni, C., Parrocchia, S., Soscia, F., Marrone, R., Serafini, G., Spaziani, C., Clerici Bagozzi, F., La Mura, A., Montesano, P., Saccoccio, O., Saviano, R., Ullucci, M., Dalla Vecchia, D., Manzi, P., Morgante, A. S., Moscardini, M. L., Natalini Raponi, G., Pitorri, A., Masala, P., Pallozzi, L., Silvestri, A., Vagni, V., Zarelli, L., Caterini, A., Curzi, M., Beggiato, S., Moscatelli, M. M., Sguazzini, G., Panepuccia, L., Pizziconi, G., Salvati, O., Bianchi, U., Lucarelli, B., Bianchini, C., Cava, M. C., Piscioneri, C., Tana, M., Ascenzi, M. P., Cicogna, V. A., Colantuono, G., Cammarota, M., Salera, E., Celiberti, A., Carbone, A., Ciavarella, M., Ciccotosto, N., Quintavalle, G., Riccioni, C., Squarcione, S., Lanini, S., Grilli, E., and Agresta, A.

Subjects
Time Factors, Cesarean Section, Incidence, caesarean section, post-discharge surveillance, surgical site infection, microbiology (medical), Patient Discharge, Anti-Bacterial Agents, Pregnancy, Risk Factors, Population Surveillance, Humans, Surgical Wound Infection, Female
Abstract

Surgical site infections (SSI) after caesarean section (CS) represent a substantial health system concern. Surveying SSI has been associated with a reduction in SSI incidence. We report the findings of three (2008, 2011 and 2013) regional active SSI surveillances after CS in community hospital of the Latium region determining the incidence of SSI. Each CS was surveyed for SSI occurrence by trained staff up to 30 post-operative days, and association of SSI with relevant characteristics was assessed using binomial logistic regression. A total of 3,685 CS were included in the study. A complete 30 day post-operation follow-up was achieved in over 94% of procedures. Overall 145 SSI were observed (3.9% cumulative incidence) of which 131 (90.3%) were superficial and 14 (9.7%) complex (deep or organ/space) SSI; overall 129 SSI (of which 89.9% superficial) were diagnosed post-discharge. Only higher NNIS score was significantly associated with SSI occurrence in the regression analysis. Our work provides the first regional data on CS-associated SSI incidence, highlighting the need for a post-discharge surveillance which should assure 30 days post-operation to not miss data on complex SSI, as well as being less labour intensive.

49. YEN BLOC (Book).

Author

Lucarelli, B.

Subjects
*JAPANESE yen, *NONFICTION
Abstract

Reviews the book 'Yen Bloc: Towards Economic Integration in Asia,' by Kwan C.H.

Published
2002

50. 15 - Hematopoietic Stem/Progenitor Cells and Engineering: LONG-TERM DATA ON IMMUNE MONITORING OF CHILDREN GIVEN TCRαβ/CD19 CELL DEPLETED HLA-HAPLOIDENTICAL STEM TRANSPLANTATION (HAPLO-HSCT).

Author

Bertaina, V., Sborgia, R., Marini, O., De Luca, C., Carta, R., Becilli, M., Pagliara, D., Quagliarella, F., Lucarelli, B., Boccieri, E., Velardi, E., Algeri, M., Merli, P., Galaverna, F., and Locatelli, F.

Subjects
*HEMATOPOIETIC stem cell transplantation, *PROGENITOR cells, *ENGINEERING, *TISSUE engineering
Published
2023
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