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Abstract Separated endodontics instruments and high-density obturating materials produce metal artifacts on cone-beam computed tomography (CBCT) scans. This study evaluated a novel methodology to detect separated instruments using artifact suppression and color map algorithms with CBCT post-processing software and compared with periapical radiographs (PRs). Endodontic instruments were incorporated into 168 root canals filled with four sealers. Additionally, 40 root canals were only filled, serving as control. CBCT scans were acquired in PreXion-3D-Elite, and digital PRs were taken in distoradial, mesioradial, orthoradial, and proximal directions. The treated teeth were analyzed using an artifact suppression algorithm combined with a color map algorithm. The separated instruments appear in the color map with larger expansion in red to allow identification. This map provides valuable information by showing dynamic visualization toward the point of expansion of the high-density object, hence suggesting a separated instrument. The chi-square test was used to compare the separated instruments among the imaging methods. Bonferroni correction was used for multiple comparisons. Statistical significance was considered P

Electric vehicles (EVs) are the best solution to tackle the critical challenge of reducing carbon emissions in the transportation sector. However, the widespread adoption of EVs relies on advancing fast-charging infrastructure technology. This includes overcoming challenges related to operating under disturbed conditions, which can impact the stability of the internal control loop. This article presents a method for robustly tuning a generalized predictive control (GPC) for an EV charger grid converter. This approach aims to enhance its performance in the face of disturbances in the grid voltage and internal filter parameters. One significant scientific gap in applying GPC in grid-tied converters concerns systematic tuning. This article addresses this gap by explicitly analyzing the impact of tuning on the stability and robustness of the GPC controller. The concept of robust stability margin, derived from singular value decomposition, is used for this purpose. Experimental results obtained from an EV charger prototype validated the tuning proposal aimed at maximizing the robustness and performance of the grid converter. The tests with different internal filters guaranteed a performance level within the defined error band. Furthermore, experimental tests have shown that the proposed controller is more robust than conventional MPC.

Objetivo: Analisar a eficácia da reabilitação da marcha de idosos submetidos à artroplastia total de quadril (ATQ). Método: Foi conduzida uma revisão sistemática da literatura nas bases de dados MedLine, SciELO, PEDro e Cochrane. Os artigos identificados pela estratégia de busca inicial foram avaliados conforme os seguintes critérios de inclusão: (1) desenho de estudo: ensaio clínico aleatorizado (ECA), (2) população de idosos com média de idade acima de 60 anos, submetidos à ATQ, (3) comparação de efeitos de intervenção entre dois ou mais grupos, (4) desfecho relacionado à análise da marcha. Resultados: Foram encontrados 6 ECAs cuja qualidade metodológica variou entre 3 e 7 (4,33 ± 1,37) de acordo com a escala PEDro. O protocolo de reabilitação e as medidas utilizadas apresentaram considerável variação entre estudos, porém foi possível observar que o grupo experimental, em todos os estudos analisados, apresentou resultados significativamente superiores aos obtidos pelo grupo controle em variáveis relacionadas à marcha, tais como: dor, distância caminhada e capacidade física. Conclusão: Apesar do número limitado de estudos e de suas diferenças metodológicas, foi possível observar evidências que apoiam a realização de exercícios terapêuticos variados no processo de reabilitação dessa população.

Abstract: Cone beam computed tomography (CBCT) is an imaging exam used increasingly in various fields of dentistry, and a greater number of endodontists are progressively gaining access to this technology. This study focused on applying an artifact suppression algorithm featured in CBCT software, and designed specifically to address artifacts related to root canal filling materials. Method The sample consisted of eighty-four mandibular molars, with mesial root canals endodontically treated by using the lateral condensation technique. Four root canal sealers were applied: G1 – Sealapex®, G2 – AH Plus®, G3 – Endofill®, and G4 – Bio-C Sealer. CBCT scans were taken using PreXion 3D Elite®. Initially, the diameter of the root canal filling (in the mesiodistal and buccolingual directions) was measured using a digital micrometer (control). Next, these diameters were reevaluated in the CBCT images using the blooming artifact reduction (BAR) tool of the e-Vol DX software. The Van der Waerden nonparametric analysis of variance was performed, followed by applying the Tukey test to the normalized data. The significance level was set at α = 5%. Results There were no statistically significant differences (p>0.05) in the measurement of original root canal filling materials obtained by the micrometer versus the e-Vol DX software in the mesiodistal and buccolingual directions. Conclusions The tested software algorithm effectively suppressed artifacts resulting from obturation materials.

Objetivo: caracterizar o perfil de gestantes que não praticam exercícios físicos. Métodos: pesquisa descritiva de abordagem quantitativa, realizada no período entre outubro e dezembro de 2021, por meio de questionário disponibilizado pelo Google Forms® com 65 gestantes que não praticavam exercícios físicos. As participantes foram captadas por meio da técnica bola de neve. Os dados foram analisados com recurso da estatística descritiva simples em frequência absoluta e relativa. Foram respeitados todos os aspectos éticos em pesquisa com seres humanos e o projeto foi aprovado pelo Comitê de Ética em Pesquisa com parecer nº 5.047.268. Resultados: o perfil de gestantes que não praticam exercício físico evidenciou que elas são, em sua maioria, casadas (69,23%), possuem ensino superior completo (36,92%) e renda familiar acima de três salários mínimos (36,92%). Os motivos mais comuns para não praticar exercícios físicos foram falta de tempo para ir à academia (33,84%) e ausência do hábito de praticar exercício físico (29,24%). Conclusão: reforça-se a necessidade de intervenção em prol da promoção de saúde nas gestantes, tendo em vista os múltiplos benefícios que a prática de exercício físico desencadeia para o binômio mãe-bebê.

El objetivo del trabajo fue evaluar la composición nutricional del orujo de ciruela, digestibilidad total y la degradabilidad ruminal de la materia seca y la fracción fibra en cabras. Se utilizaron 4 cabrillas y se suministraron 2 dietas: heno a base de alfalfa (SOC); heno a base de alfalfa + orujo de ciruela (0,5% del PV/día) (COC). Se determinó el consumo total, la digestibilidad total aparente in vivo, la degradabilidad ruminal in vitro de la materia seca y la fibra detergente neutra a las 24 y 48 horas de incubación. El consumo del heno de alfalfa, el de materia seca total y la tasa de sustitución, no observaron diferencias entre tratamientos (p=0,143; p=0,540 y p=0,528, respectivamente). La digestibilidad total aparente de la materia seca consumida, entre COC y SOC arrojaron valores similares (p=0,881). La degradabilidad ruminal in vitro de la materia seca del orujo de ciruela a las 24 y 48 h de incubación fue semejante al heno de alfalfa. La degradabilidad ruminal in vitro de la FDN del heno de alfalfa a las 24 de incubación, no arrojó diferencias (p>0,05) entre COC y SOC. La degradabilidad de la FDN a las 48 h de incubación, fue menor en COC (p

ABSTRACT Objective: The aim of the present study is to evaluate the occurrence of dentinal defects on the apical surface after rotary instrumentation at different working lengths with Trunatomy Prime system, with or without the use of a glide path file. Methods: Twenty human single-rooted mandibular premolars were selected and divided into 2 experimental groups (n=10). GTP group (Glide Path + Trunatomy Prime), the TP group (Trunatomy Prime). Results: To check the agreement between the examiners, the Kappa test was performed. Subsequently, the results were subjected to the Shapiro-Wilk normality test. The sample showed abnormal behavior and were subjected to the non-parametric Mann Whitney test with a significance level of 5%. No significant difference was found between the groups. Conclusion: It is concluded that there was no causal relationship with the formation of dentin defects with and without the use of glide path files at different limits of instrumentation with Trunatomy files.

Plantas de feijão podem ter seu desenvolvimento estimulado através da associação com bactérias promotoras do crescimento de plantas, como por exemplo as bactérias do gênero Azospirillum, No entanto, a forma de aplicação e a dose de inoculante bacteriano utilizado podem interferir nos resultados. Objetivo do trabalho foi verificar a influência da forma de aplicação, foliar ou na semente, de diferentes doses de Azospirillum, no desenvolvimento do feijão carioca. Foi realizado um experimento em telado, coberto com plástico transparente e no entorno cercado por sombrite, pertencente ao Viveiro da Universidade Federal de Mato Grosso, Campus de Sinop. O solo foi coletado do subsolo na reserva de mata da UFMT/ Sinop, (Latossolo Vermelho Escuro Distrófico, camada de 20-40 cm). O solo foi seco ao ar, peneirado em peneira de 4 mm e autoclavado (40 minutos a 121ºAtm). A calagem e adubação foi realizada em função da análise de fertilidade do solo. Foram utilizadas para a semeadura sementes de feijão carioca ANfc9. Os tratamentos foram constituídos por diferentes doses de Azospirillum brasilense (inoculante líquido comercial contendo a estirpe Ab-V5 com concentração 1x108 UFC/mL), sendo as aplicações realizadas sobre as sementes na semeadura e via foliar no estádio vegetativo V3. Sendo constituídos dos seguintes tratamentos: T1 - Inoculação na semente (0 mL/25 kg de semente); T2 - Inoculação via foliar em V3 (0 mL/25 kg de semente); T3 - Inoculação na semente (250 mL/25 kg de semente); T4 - Inoculação via foliar em V3 (250 mL/25 kg de semente); T5 - Inoculação na semente (500 mL/25 kg de semente); T6 - Inoculação via foliar em V3 (500 mL/25 kg de semente ); T7 - Inoculação na semente (750 mL/25 kg de semente); T8 - Inoculação via foliar em V3 (750 mL/25 kg de semente); T9 - Inoculação na semente (1000 mL/25 kg de semente); T10 - Inoculação via foliar em V3 (1000 mL/25 kg de semente). O delineamento experimental foi de blocos casualizados (DBC) com 10 tratamentos e 4 blocos. O teor de clorofila foi avaliado aos 13, 34 e 40 dias após a semeadura. O experimento foi conduzido até o início do período reprodutivo (estádio R5), quando as plantas foram coletas e avaliados: o diâmetro do caule, a altura da planta, o comprimento dos entrenós, a área foliar e o acúmulo de massa seca da parte aérea e da raiz. A forma de aplicação do inoculante não interferiu no desenvolvimento das plantas. A massa seca da parte aérea foi positivamente influenciada pelo aumento da dose de inoculante contendo Azospirillum brasilense aplicado nas plantas de feijão.

The aim of the following work was to evaluate a diet formulated with byproducts from the brewing and wine industry for lactating goats and quantify its potential in terms of nutritional quality and quantity. Twelve multiparous Nubian x Saanen goats, 2.75 years old (+ 1,24) during an experimental period of 12 weeks: 2 weeks of habituation and 10 weeks of testing. In both diets the goats grazed 6 hours on natural grass. Diet T0 (n = 6): Commercial feed: 500 g/day/goat (16% CP and 2.6 Mcal ME/kg DM) and diet T1 (n = 6): non-traditional balanced feed: 500 g/day/goat (16% CP and 2.6 Mcal ME/kg DM). Productive performance and health parameters were evaluated in goats fed with both diets during a period of 5 weeks starting 35 days postpartum. Total dry matter intake (DMI), milk production and corrected (MY and MYC), live weight (BW), body condition score (BCS), degree of FAMACHA© and quantitative coproparasitological diagnosis (EPG and OPG) were measured. A greater DMI was observed at T0 compared to T1 (p < 0.05). MY, MYC, BW, BCS, FAMACHA©, EPG and OPG did not show significant differences (p > 0.05) between both diets (T0 vs T1) throughout the experimental period evaluated. Goat health parameters throughout the study were within the physiological range during the production cycle and did not interfere with dietary treatments. The formulation of the diet with barley bagasse and grape pomace in dairy goats had a productive behaviour and health parameters like those of the commercial diet evaluated, without affecting milk production.

Abstract This paper presents an analysis of the fault current contributions of small‐scale single‐phase photovoltaic inverters under grid‐connected operation and their potential impact on the protection of distribution systems. To conduct this analysis, an autotransformer‐based voltage dip generator is proposed as a means to test the photovoltaic inverters' contribution to short‐circuit currents. Laboratory tests are then performed to obtain the short‐circuit current contribution of eight single‐phase photovoltaic inverters. Using the short‐circuit current data obtained, a behaviour model is developed and simulated on Matlab‐Simulink. The model is then applied to a real distribution system and case studies are conducted to simulate the potential impacts on the protection system. Results indicate that while the massive penetration of small‐scale single‐phase photovoltaic inverters can alter the protection system's operating time, the impacts are not significant. Only in very specific scenarios, such as events related to high impedance faults, some impact can be observed. In these situations, the presence of photovoltaic inverters further complicates the already difficult task of identifying high impedance faults through conventional overcurrent protections. This study provides valuable insights into the integration of photovoltaic inverters into distribution systems, and can aid in the development of effective protection measures for future grid designs.

Abstract Papaya (Carica papaya) is a trioecious species with female, male, and hermaphrodite plants. Given the sex segregation, selecting hermaphroditic plants is vital for orchard establishment due to their greater commercial value. However, selecting hermaphrodite plants through sexing is laborious and costly. Moreover, environmental stressors can exacerbate the issue by potentially inducing abnormal flower development, thus affecting fruit quality. Despite these challenges, the molecular mechanisms governing sex development in papaya remain poorly understood. Thus, this study aimed to identify proteins associated with sex development in female and hermaphrodite flowers of papaya through comparative proteomic analysis. Proteins from flower buds at the early and late developmental stages of three papaya genotypes (UENF-CALIMAN 01, JS12, and Sunrise Solo 72/12) were studied via proteomic analysis via the combination of the shotgun method and nanoESI-HDMSE technology. In buds at an early stage of development, 496 (35.9%) proteins exhibited significantly different abundances between sexes for the SS72/12 genotype, 139 (10%) for the JS12 genotype, and 165 (11.9%) for the UC-01 genotype. At the final stage of development, there were 181 (13.5%) for SS72/12, 113 (8.4%) for JS12, and 125 (9.1%) for UC-01. The large group of differentially accumulated proteins (DAPs) between the sexes was related to metabolism, as shown by the observation of only the proteins that exhibited the same pattern of accumulation in the three genotypes. Specifically, carbohydrate metabolism proteins were up-regulated in hermaphrodite flower buds early in development, while those linked to monosaccharide and amino acid metabolism increased during late development. Enrichment of sporopollenin and phenylpropanoid biosynthesis pathways characterizes hermaphrodite samples across developmental stages, with predicted protein interactions highlighting the crucial role of phenylpropanoids in sporopollenin biosynthesis for pollen wall formation. Most of the DAPs played key roles in pectin, cellulose, and lignin synthesis and were essential for cell wall formation and male flower structure development, notably in the pollen coat. These findings suggest that hermaphrodite flowers require more energy for development, likely due to complex pollen wall formation. Overall, these insights illuminate the molecular mechanisms of papaya floral development, revealing complex regulatory networks and energetic demands in the formation of male reproductive structures.

Southern leaf blight (SLB), caused by Bipolaris maydis, poses a significant threat to maize and popcorn production. To understand the molecular mechanisms underlying SLB resistance, we conducted a high-throughput proteomic analysis comparing SLB-resistant (L66) and SLB-susceptible (L51) popcorn genotypes at four and ten days after inoculation (DAI). A total of 717 proteins were identified, with 151 differentially accumulated proteins (DAPs) between the genotypes. Eighteen DAPs exhibited the same regulatory pattern in both the SLB-resistant and SLB-susceptible genotypes at four (R4/S4) and ten (R10/S10) DAI. The protein-protein interaction (PPI) network of differentially accumulated proteins (DAPs) linked to SLB resistance and susceptibility enriched specific metabolic pathways in the SLB response, including photosynthesis, ribosome, ascorbate and aldarate metabolism, glutathione metabolism, and carbon metabolism. Proteins such as photosystem II 11 kD protein (B4FRJ4, PSB27-1), which was up-regulated at both time points (R4/S4 and R10/S10), and 60S acidic ribosomal protein P0 (A0A1D6LEZ7, RPP0B), which was unique to the resistant genotype at both time points (R4 and R10), highlighted the importance of maintaining photosynthetic efficiency and protein synthesis during pathogen attack. Additionally, dehydroascorbate reductase like-3 (B4F817, DHAR3) was consistently up-regulated at both time points in resistant genotypes, emphasizing its role in redox balance and ROS detoxification. In contrast, glyceraldehyde-3-phosphate dehydrogenase (K7UGF5, GAPC2), a glycolytic enzyme, was unique to the susceptible genotype, suggesting its involvement in managing energy metabolism under stress conditions. Our findings suggest that resistance to SLB in popcorn involves a combination of enhanced photosynthetic repair, redox homeostasis, and ribosomal protein activity, providing new potential molecular targets, such as DHAR3 and RPP0B, for genetic improvement in SLB resistance. These results offer valuable insights into breeding programs aimed at developing SLB-resistant popcorn varieties.

ABSTRACT Light stress damages the photochemical apparatus and affects seedling growth of forest species. Using potassium silicate (K2SiO3) can mitigate these deleterious effects and contribute to the acclimatization and robustness of seedlings. This study evaluated the effect of K2SiO3 and shading levels on the photochemical and growth of Alibertia edulis (Rich) A. Rich seedlings. The experiment was arranged under three light conditions based on shading levels of 0 % (full sun), 30 %, and 70 %. Four doses of K2SiO3 applied through foliar spray were tested: 0.0, 2.5, 5.0, and 10.0 mL L–1. Cultivation under full sun and under 70 % of shade was stressful for A. edulis, while cultivation under 30 % of shade improved plant growth. Increasing application of K2SiO3 in seedlings under full sun damaged the reaction center, causing lower photochemical yields, but increased the photochemical efficiency of photosystem II under 30 % of shade. Using K2SiO3 contributed to leaf water regulation while applying 10.0 mL L–1 increased chlorophyll indices, leaf area, physiological indices, and the quality of seedlings cultivated under full sun and 30 % of shade. Using 10.0 mL L–1 K2SiO3 mitigated the negative effects of light stress under full sun. It provided high photochemical efficiency, morphology aspects, and Dickson quality index A. edulis seedlings in environments with high or moderate light availability.

Objective: To analyze variability in the distance between the Anterior Ethmoidal Artery (AEA) and the anterior Skull Base (SB), as well as the frequency of lateral asymmetry in a Latin American population using computed tomography. Methods: A total of 250 computed tomography scans of paranasal sinuses in coronal reconstruction (500 AEAs) were analyzed. After determining the image with the best anatomical view of the artery, the distance between its midpoint and the ethmoidal roof was measured, and the images were independently interpreted by 2 physicians. Results: Of the 500 AEAs, 279 (55.8%) adhered to or passed through the SB at a distance of 0 mm. A total of 221 AEAs (44.2%) were at some distance from the SB, of which 107 (48.4%) were on the right side, ranging from 1.18 to 6.75 mm, and 114 (51.5%) were on the left side, ranging from 1.15 to 6.04 mm. The overall mean distance between the AEA and SB was 1.22 (SD = 1.57) mm, increasing to 2.77 (SD = 1.14) when the arteries adhered to the SB were excluded. Seventy-six individuals (30.4%) had a lateral distance variation > 1 mm. Conclusion: Our study includes the largest sample of AEA analyzed with computed tomography scans of paranasal sinuses. There was some distance between the AEA and SB in almost half the patients, and we found a high rate of lateral variability >1 mm. Level of evidence: Level 3.

ABSTRACT Objective: Substance misuse can lead to several consequences for physical and mental health. Physical exercise is an important ally to pharmacological and psychotherapeutic treatment for substance use. However, the literature is still scarce regarding long-term interventions. Thus, this study aims to describe the acceptability and effects of combined physical training intervention (aerobic and strength). Methods: This study comprises an n-of-1 clinical trial that was performed with a 64-year-old male individual with alcohol use disorder. The treatment lasted 12 weeks and evaluated the association of multidisciplinary interventions on quality of life, depressive symptoms, cognitive impairment, and anxiety. Results: The participant improved general quality of life (12.5%), no alterations were found for depressive symptoms, there was an improvement in cognition (20%), as well a reduction in the trait (16.2%) and state (14.7%) anxiety symptoms of the participant. Conclusions: These findings allude to the importance of non-drug therapeutic resources such as structured physical exercise, associated with other offers in the treatment of alcohol use disorder.

Abstract Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma and hepatocellular carcinoma). We discovered mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers. As in human cancer, TP53 is the most commonly mutated gene, detected in 22.5% of canine tumors overall. Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include NRAS G61R and PIK3CA H1047R in hemangiosarcoma, ERBB2 V659E in pulmonary carcinoma, and BRAF V588E (equivalent of V600E in humans) in urothelial carcinoma. Our findings better position canines as a translational model of human cancer to investigate a wide spectrum of targeted therapies.

Background/Objectives: The aim of this study was to evaluate incidental findings in the mandible after the placement of dental implants using a new cone–beam computed tomography (CBCT) software. Methods: The initial sample consisted of 2872 CBCT scans of patients of both sexes. The parameters evaluated in this study were the location of the implants in the mandible, implant length, anatomical relationship of the implant with the mandibular canal, presence or absence of damage to the adjacent teeth, presence or absence of implant fractures, and presence or absence of bone support. Fisher’s exact test was performed to compare the variables. The significance level was set at p = 0.05. Results: Out of 2872 CBCT scans, 214 images of patients with an average age of 44.5 years were included. The most frequent location of the implants was the posterior region (93.5%), with 54% of the implants having a length between 9 and 14 mm. It was found that 92% of the implants were positioned above the mandibular canal. Damage to adjacent teeth was observed, with no correlation with the implant positioning (p = 1.000). In 100% of cases of implants in the anterior region, there was bone support. Fracture was observed in 1.7% of implants with a length between 9 and 14 mm. Conclusions: The installation of implants in the mandible occurs more frequently in the posterior region, with a high presence of bone support and a low incidence of damage to adjacent teeth, anatomical structures, and fractures.

The use of high-quality Urochloa decumbens seeds is an essential factor for the establishment of pastures, and osmopriming under stress conditions may improve seed performance. This study was conducted at the Universidade Federal de Viçosa in a completely randomized design and aimed to evaluate the effects of osmopriming and its relationship with physical and physiological attributes of U. decumbens seeds subjected to water deficit. Seeds from ten lots were primed in H2O (0 MPa) and PEG (−0.8 MPa), KNO3 (0.2%), and SNP (0.10 mmol L−1) solutions for 24 hours. Unprimed seeds were used as control. The seeds were evaluated in two trials after osmopriming. Trial I consisted of the X-ray test to evaluate physical attributes and germination and vigor tests. In Trial II, the seeds were placed to germinate under favorable (0 MPa) and water deficit conditions (−0.2 MPa) to evaluate physiological attributes. In general, osmopriming of U. decumbens seeds assisted in increasing physical attributes such as area, gray scale, perimeter, and tissue density. Osmopriming does not contribute to the best physiological performance of U. decumbens seeds under ideal germination conditions (0 MPa). However, osmopriming with SNP (0.10 mmol L−1) and PEG (−0.8 MPa) for 24 hours contributes to the better physiological performance of seeds under water deficit.

Enteropathies are prevalent in dog internal medicine, and their diagnosis involves a lengthy process. One of the tests requested is for biomarkers, which are important as they can provide data on intestinal functionality, intensity of inflammation, and response to treatment, and can help determine the prognosis. This study aimed to conduct a literature review on the main serum and fecal intestinal biomarkers in dogs and proposed to refine the correlations between these indicators and enteropathies. It was observed that the main biomarkers used in the intestinal evaluation of dogs were alpha 1-proteinase inhibitory factor, immunoglobulin A, methylmalonic acid, serum folate, serum cobalamin, C-reactive protein, fecal and serum calprotectin, and dysbiosis index. However, we suggest that more research be carried out to clarify the relationship between enteropathies and intestinal biomarkers. We noticed a lack of studies on specific intestinal markers and indicator variables in healthy dogs and those with various enteropathies; moreover, no data are available on the association of these laboratory parameters.

Abstract Spontaneous tumors in canines share significant genetic and histological similarities with human tumors, positioning them as valuable models to guide drug development. However, current translational studies have limited real world evidence as cancer outcomes are dispersed across veterinary clinics and genomic tests are rarely performed on dogs. In this study, we aim to expand the value of canine models by systematically characterizing genetic mutations in tumors and their response to targeted treatments. In total, we collect and analyze survival outcomes for 2119 tumor-bearing dogs and the prognostic effect of genomic alterations in a subset of 1108 dogs. Our analysis identifies prognostic concordance between canines and humans in several key oncogenes, including TP53 and PIK3CA. We also find that several targeted treatments designed for humans are associated with a positive prognosis when used to treat canine tumors with specific genomic alterations, underscoring the value of canine models in advancing drug discovery for personalized oncology.

Introduction Chagas disease is an important public health problem in Latin American countries, affecting ∼ 6 million people within the region. In patients with chronic Chagas disease who undergo some type of immunosuppression reactivation of the acute form may occur, and manifestations involve many organs, including the central nervous system. Tumor-like brain reactivations are well described in patients with acquired immunodeficiency syndrome; however, this is a very rare event among Chagasic patients immunosuppressed after a heart transplantation.

ABSTRACT Objective: To evaluate the clinical and epidemiological profile of patients diagnosed with spinal fractures treated at Hospital Regional de São José Dr. Homero de Miranda Gomes (HRSJ), from the municipality of São José/SC, from March 2020 to March 2021. Methods: An observational study was carried out with a cross-sectional design and analysis of secondary data obtained by reviewing electronic medical records of patients diagnosed with spinal fractures treated during the study period. Associations of categorical variables were tested using Pearson’s chi-square test. The statistical significance level adopted was 5% (p

ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and secretions in children without symptoms of COVID-19, with no history of recent upper airway infection. We studied 48 children undergoing tonsillectomy due to snoring/OSA or recurrent tonsillitis between October 2020 and September 2021. Nasal cytobrushes, nasal washes, and tonsillar tissue fragments obtained at surgery were tested by RT-qPCR, immunohistochemistry (IHC), flow cytometry, and neutralization assay. We detected the presence of SARS-CoV-2 in at least one specimen tested in 27% of patients. IHC revealed the presence of the viral nucleoprotein in epithelial surface and in lymphoid cells in both extrafollicular and follicular regions, in adenoids and palatine tonsils. Also, IHC for the SARS-CoV-2 non-structural protein NSP-16 indicated the presence of viral replication in 53.8% of the SARS-CoV-2-infected tissues. Flow cytometry showed that CD20+ B lymphocytes were the most infected phenotypes, followed by CD4+ lymphocytes and CD123 dendritic cells, CD8+ T lymphocytes, and CD14+ macrophages. Additionally, IF indicated that infected tonsillar tissues had increased expression of ACE2 and TMPRSS2. NGS sequencing demonstrated the presence of different SARS-CoV-2 variants in tonsils from different tissues. SARS-CoV-2 antigen detection was not restricted to tonsils but was also detected in nasal cells from the olfactory region. Palatine tonsils and adenoids are sites of prolonged RNA presence by SARS-CoV-2 in children, even without COVID-19 symptoms. IMPORTANCE This study shows that SRS-CoV-2 of different lineages can infect tonsils and adenoids in one quarter of children undergoing tonsillectomy. These findings bring advancement to the area of SARS-CoV-2 pathogenesis, by showing that tonsils may be sites of prolonged infection, even without evidence of recent COVID-19 symptoms. SARS-CoV-2 infection of B and T lymphocytes, macrophages, and dendritic cells may interfere with the mounting of immune responses in these secondary lymphoid organs. Moreover, the shedding of SARS-CoV-2 RNA in respiratory secretions from silently infected children raises concern about possible diagnostic confusion in the presence of symptoms of acute respiratory infections caused by other etiologies.

Abstract: The demand for techniques that make it possible to assess the physiological potential of seeds quickly and assertively make near-infrared spectroscopy (FT-NIR) and seedling analysis using ILASTIK software promising tools. The aim of this study was to evaluate the physiological potential of Urochloa decumbens seeds using near-infrared spectroscopy (FT-NIR) and ILASTIK software. Seeds from 10 lots of U. decumbens were classified according to their physiological potential (germination and vigor) and then FT-NIR spectra were obtained from individual seed samples, the original spectra being pre-processed with different dispersion correction methods used for the construction of a classification model through partial least squares discriminant analysis (PSL-DA). For the ILASTIK evaluation, the seedlings were photographed at 7 and 14 days of germination and the trained classifier was applied to the images, generating data on the numbers of strong seedlings, weak seedlings and non-germinated seeds. With data from the FT-NIR technique pre-processed by the 2nd derivative of Savitzky-Golay, it was possible to obtain a classification model with high efficiency to discriminate the classes regarding the physiological potential of the seeds. ILASTIK was efficient to classify seeds according to their physiological potential after only 7 days of germination. FT-NIR and ILASTIK analyses are non-destructive and fast alternatives, with great potential for quality control of U. decumbens seed lots.

Este artigo apresenta algumas reflexões sobre a discriminação à população negra no Brasil, a partir de pesquisa realizada no Estágio de Práticas Investigativas II e III do curso de graduação em Psicologia da Pontifícia Universidade Católica de Minas Gerais, unidade Coração Eucarístico. Na análise do histórico brasileiro encontram-se estudos que revelam a grande importância que se tem ao investigar as consequências sociais e culturais da escravidão no Brasil, pois são perceptíveis os resquícios desse ocorrido nos dias atuais. Diante das pesquisas e análises infere-se a imprescindibilidade dos estudos sobre os impactos desse dado histórico, inseridos em uma instituição social fundamental, a escola. Para melhor compreensão do tema, o método qualitativo tornou-se ferramenta para a elaboração da pesquisa descritiva relatada e discutida neste trabalho, com base em uma entrevista semiestruturada com um estudante negro, graduando em Psicologia, realizada em tempo real em ambiente virtual de comunicação instantânea. Os resultados apontam a presença de uma lacuna que ainda deve ser trabalhada, manifestada e preenchida pela construção de identidade e extensão das referências negras dentro da escola. Portanto, verifica-se que sem âmbito para dialogar um determinado fato não há condições para deliberações. O movimento negro tem alcançado diversas conquistas nos últimos anos, contudo, ainda há outras ocorrências que demandam mudanças.

Introdução: As características clínicas da leishmaniose dependem das propriedades do parasita (infecciosidade, patogenicidade, virulência) e fatores do hospedeiro (idade, estado nutricional, imunidade inata e celular). A reativação espontânea da leishmaniose, rara em pacientes imunocompetentes, geralmente ocorre devido à resistência a medicamentos ou inadequação terapêutica. Este relato de caso objetiva demonstrar uma apresentação rara de leishmaniose. O quadro é atípico pelo envolvimento da epiglote e evolução inesperada para um paciente imunocompetente. Descrição do caso: Paciente masculino, 51 anos, lavrador aposentado, tabagista 56 maços-ano, residiu em Marabá-PA por 30 anos, com histórico de leishmaniose cutânea aos 14 anos (lesões ulceradas crônicas em face e membros). Em 2010, apresentou febres vespertinas, emagrecimento, tosse e odinofagia, com ressurgimento de lesões em região nasal e cavidade oral em 2014. Foi tratado em 2018 com anfotericina B lipossomal 2700mg e em 2019, por recidiva, com nova dose 2500mg. Em 2022, interna por quadro de disfagia, odinofagia, disfonia, escarros hemoptóicos, perda ponderal e febre vespertina, com lesão erosiva em septo e desabamento de pirâmide nasal. Escarro e baciloscopia para tuberculose negativos. Tomografia mostra palato mole deslocado e aderido à parede posterior da rinofaringe, com obliteração da coluna aérea; epiglote não caracterizada, formação tecidual de aspecto expansivo em sua topografia e obliteração subtotal da valécula. À laringoscopia: importante deformação anatômica com ausência de epiglote, extensas áreas infiltradas com granulações e placas de fibrina em cordas vocais. Biópsia incisional da lesão laríngea evidenciou inflamação crônica inespecífica com presença de escassas amastigotas. Evoluiu com necessidade de traqueostomia e gastrostomia e realizado novo tratamento com anfotericina B lipossomal 3000 mg. Apresentou boa evolução clínica, recebendo alta para seguimento ambulatorial. Comentários: A leishmaniose mucocutânea pode simular condições infecciosas e neoplásicas, tornando o diagnóstico desafiador. A falha no diagnóstico precoce e a inadequação terapêutica podem resultar em pior prognóstico e maior chance de recidiva. Ambos os fatores foram determinantes na evolução do caso relatado e na disfunção orotraqueal perpetuada no paciente. Por fim, o tratamento, quando corretamente instituído, gera excelente resposta clínica e laboratorial, sendo imprescindível à contenção do quadro.

Resenha do Livro História das Mulheres, Relações de Gênero e Sexualidades em Goiás

Severe traumatic brain injury (sTBI) is an important cause of disability and mortality and affects people of all ages. Current scientific evidence indicates that motor dysfunction and cognitive impairment are the main limiting factors in patients with sTBI. Transcranial direct current stimulation (tDCS) seems to be a good therapeutic option, but when it comes to patients with sTBI, the results are inconclusive, and some protocols have not yet been tested. In addition, there is still a lack of information on tDCS-related physiological mechanisms, especially during the acute phase. In the present study, based on current evidence on tDCS mechanisms of action, we hypothesized that performing tDCS sessions in individuals with sTBI, especially in the acute and subacute phases, together with conventional therapy sessions, could improve cognition and motor function in this population. This hypothesis presents a new possibility for treating sTBI, seeking to elucidate the extent to which early tDCS may affect long-term clinical outcomes.

(1) Background/Objectives: Accurate determination of chronological age is crucial in legal dental identification. This study aimed to compare the effectiveness of different formulas in estimating the age of a Brazilian subpopulation by analyzing the pulp/tooth ratio of the maxillary canine and mandibular second premolar in panoramic and periapical radiographs. (2) Methods: The sample consisted of panoramic and periapical radiographs of 247 individuals. The file of each radiograph was opened in the Adobe Photoshop CS4® program to outline and obtain values in pixels for calculating the pulp/tooth ratio. Statistical analysis was conducted using the SPSS program, with a significance level set at 5%. (3) Results: The interclass correlation coefficient demonstrated excellent intra-observer agreement (0.990–0.999). The determination coefficients (R2) suggested that only 30–35% of the actual age results could be explained by the pulp/tooth ratio. The smallest differences were observed with Cameriere’s formula for the mandibular second premolar on panoramic radiographs (+4.1 years). The greatest differences were found with the formulas for the mandibular second premolar in panoramic radiographs of the Korean (+12.5 years) and Portuguese (−12.1 years) populations. (4) Conclusions: The equations employed showed little agreement between the actual age and the estimated age.

(1) Background: This study assessed the spatial position and anatomical features associated with impacted third molars through a map-reading strategy employing cone-beam computed tomography (CBCT). (2) Methods: The positioning of impacted third molars on CBCT was assessed using Winter’s and Pell and Gregory’s classifications. External root resorption in mandibular second molars was categorized according to Herman’s classification. Additionally, the relationship between the mandibular third molar root apex and the mandibular canal was examined. Comparative statistical analysis was conducted using Fisher’s exact test, with a significance level considered as 5%. (3) Results: The results indicated that, based on Winter’s classification, 48.06 % of impacted teeth were positioned mesioangularly. Employing Pell and Gregory’s classification, 43.22% of the impacted molars fell into positions B and C, with 54.2% classified as Class II. A notable 69.7% of teeth exhibited no contact between the root apex and the mandibular canal, and external root resorption in the distal aspect of the second molar was absent in 88.7% of cases. (4) Conclusions: Utilizing the map-reading strategy with CBCT scans to assess the anatomical positions and characteristics of impacted third molars enhances professional confidence and sets a standard for quality and safety in the surgical procedure for patients.

Coronavirus disease (COVID-19) is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus and may lead to severe respiratory failure and the need for mechanical ventilation (MV). At hospital admission, patients can present with severe hypoxemia and dyspnea requiring increasingly aggressive MV strategies according to the clinical severity: noninvasive respiratory support (NRS), MV, and the use of rescue strategies such as extracorporeal membrane oxygenation (ECMO). Among NRS strategies, new tools have been adopted for critically ill patients, with advantages and disadvantages that need to be further elucidated. Advances in the field of lung imaging have allowed better understanding of the disease, not only the pathophysiology of COVID-19 but also the consequences of ventilatory strategies. In cases of refractory hypoxemia, the use of ECMO has been advocated and knowledge on handling and how to personalize strategies have increased during the pandemic. The aims of the present review are to: (1) discuss the evidence on different devices and strategies under NRS; (2) discuss new and personalized management under MV based on the pathophysiology of COVID-19; and (3) contextualize the use of rescue strategies such as ECMO in critically ill patients with COVID-19.

The study of trafficking in persons for prostitution requires systematic and in-depth analysis, as it is a complex phenomenon resulting from multiple variables. Therefore, this work aims to map human trafficking, especially in the Brazilian context, by examining international norms and their impact on Brazilian law. At the same time, the study sheds light on the relationship between organized crime and human trafficking, considering human trafficking for sexual exploitation as a form of control of female bodies. The argument builds on the analysis of statistical data and scientific works dealing with human trafficking, prostitution, and organized crime.

Sex segregation increases the cost of Carica papaya production through seed-based propagation. Therefore, in vitro techniques are an attractive option for clonal propagation, especially of hermaphroditic plants. Here, we performed a temporal analysis of the proteome of C. papaya calli aiming to identify the key players involved in embryogenic callus formation. Mature zygotic embryos used as explants were treated with 20 μM 2,4-dichlorophenoxyacetic acid to induce embryogenic callus. Total proteins were extracted from explants at 0 (zygotic embryo) and after 7, 14, and 21 days of induction. A total of 1407 proteins were identified using a bottom-up proteomic approach. The clustering analysis revealed four distinct patterns of protein accumulation throughout callus induction. Proteins related to seed maturation and storage are abundant in the explant before induction, decreasing as callus formation progresses. Carbohydrate and amino acid metabolisms, aerobic respiration, and protein catabolic processes were enriched throughout days of callus induction. Protein kinases associated with auxin responses, such as SKP1-like proteins 1B, accumulated in response to callus induction. Additionally, regulatory proteins, including histone deacetylase (HD2C) and argonaute 1 (AGO1), were more abundant at 7 days, suggesting their role in the acquisition of embryogenic competence. Predicted protein–protein networks revealed the regulatory role of proteins 14-3-3 accumulated during callus induction and the association of proteins involved in oxidative phosphorylation and hormone response. Our findings emphasize the modulation of the proteome during embryogenic callus initiation and identify regulatory proteins that might be involved in the activation of this process.

A implementação de sistemas de informação exige esforços para condução e otimização, de forma cíclica, da operacionalização do tratamento e da recuperação de dados e informações, o que, muitas vezes, envolve dados pessoais. O papel das políticas de privacidade em sistemas de informação evidencia a exigência legal de proteção de dados pessoais. Este trabalho analisa a política de privacidade do site do Sistema Nacional de Juventude, como modelo oriundo da adaptação de um sistema de informação governamental, ao uso de identificação pessoal dos usuários por meio de mídias sociais. O modelo proposto atende ao direito de privacidade, em particular, à proteção de dados pessoais, buscando examinar aspectos gerais dos sistemas de informação e sua relação com a Ciência da Informação. Além disso, o trabalho discorre sobre privacidade e proteção de dados pessoais pelo poder público e apresenta o papel das políticas de privacidade nos sistemas de informação. Como metodologia, foi adotada uma pesquisa qualitativa alinhada a estudos da Ciência da Computação. Ao final, foram descritos os principais aspectos utilizados na adaptação do sistema de informação governamental, em particular, a política de privacidade do site mencionado, apresentando, como resultado, seu delineamento a fim de atender a Lei Geral de Proteção de Dados pessoais.

Abstract Background Transcranial direct current stimulation (tDCS) has the potential to modulate cortical excitability and enhance the effects of walking training in people with Parkinson’s disease. This study will examine the efficacy of the addition of tDCS to a task-specific walking training to improve walking and mobility and to reduce falls in people with Parkinson’s disease. Methods This is a two-arm, prospectively registered, randomized trial with concealed allocation, blinded assessors, participants and therapists, and intention-to-treat analysis. Twenty-four individuals with Parkinson’s disease, categorized as slow or intermediate walkers (walking speeds ≤ 1.0 m/s), will be recruited. The experimental group will undertake a 30-min walking training associated with tDCS, for 4 weeks. The control group will undertake the same walking training, but with sham-tDCS. The primary outcome will be comfortable walking speed. Secondary outcomes will include walking step length, walking cadence, walking confidence, mobility, freezing of gait, fear of falling, and falls. Outcomes will be collected by a researcher blinded to group allocation at baseline (week 0), after intervention (week 4), and 1 month beyond intervention (week 8). Discussion tDCS associated with walking training may help improve walking of slow and intermediate walkers with Parkinson’s disease. If walking is enhanced, the benefits may be accompanied by better mobility and reduced fear of falling, and individuals may experience greater free-living physical activity at home and in the community. Trial registration Brazilian Registry of Clinical Trials (ReBEC) RBR-6bvnx6 . Registered on September 23, 2019

ABSTRACT There is currently a lack of information regarding the performance of cover crops grown in the Coastal Tablelands region in the North of the Brazilian state of Espírito Santo, where zero tillage is increasingly being adopted. The objective of this study was to evaluate the agronomic performance of six cover crops (ruzi grass, jack bean, and the millets ADR 300, ADR 500, ADRf 6010, and BRS 1501) under two irrigation regimes. A field experiment setup was based on randomized blocks with split plots and four repetitions. Shoot dry matter content, plant height, leaf area, chlorophyll fluorescence, and root growth of the cover crops were evaluated. The irrigation regime influences the agronomic performance of most of the cover crops, with the exception of jack bean and ADRf 6010 millet, which were tolerant to water deficiency, based on our evaluations of the variables shoot dry matter, plant height, and leaf area. In terms of biomass production, ADRf 6010 millet is the most suitable crop for use in conservation systems under conditions of water stress in this region.

O Ensino Remoto Emergencial (ERE) tem sido a alternativa para muitas universidades públicas federais, desde as orientações normativas do Ministério da Educação (MEC), diante da rápida infecção pelo novo Coronavírus (COVID-19). Assim, nossa proposta, neste artigo, é apresentar, por meio de uma reflexão crítica, considerações sobre a aplicação e o uso de tecnologias digitais no ERE, como forma de contribuir à formação de professores para contextos diversos, considerando nossas experiências de ensino-aprendizagem durante esse período. O percurso teórico-metodológico deu-se na interface entre Teoria da Complexidade, conforme proposta por Morin (2007) e Moraes (2007) e o viés dos estudos do Letramento Digital, segundo Soares (2002, 2014) e Multiletramentos, de acordo com Coscarelli (2007). Como resultados, entendemos que as tecnologias digitais podem servir de trampolim à prática docente no período ERE, mas requer um pensamento sistêmico com vistas ao pensamento complexo a fim de dar conta das intercorrências e imprevisibilidades emergentes.

Objective: To compare the marginal degradation (susceptibility to marginal adaptation and marginal discoloration) of composite restorations placed in class II and V cavities using conventional and bulk-fill resin composites. Material and Methods: This study was approved by PROSPERO database (#42020201596). PubMed, Scopus, Embase, Web of Science, Lilacs, Cochrane, Open Grey, Clinical Trials, and Rebec databases were searched by three independent investigators using MeSH terms, supplementary concepts, synonyms, and free keywords, based on the PICOS strategy (P, population: restoration in permanent teeth; I, intervention: bulk-fill resin composite; C, comparison: conventional resin composite; O, outcome: marginal discoloration and adaptation; and S, study design: randomized and non-randomized clinical trials). The risk of bias was evaluated according to the Cochrane Collaboration’s tool, the meta-analyses by RevMan software, the certainty of evidence by the Grading of Recommendations Assessment, Development, and Evaluation, and the leave-one-out sensitivity test. The prevalence of successful events and the total number of restorations were used to calculate the risk difference at a confidence interval of 95%, according to a fixed-effect model. The heterogeneity was evaluated using the I2 index. Results: 16 from 10,780 studies were selected and included for qualitative and quantitative analysis. Two studies were considered as high risk of bias, one showing some concerns, and 13 as low risk of bias. Four meta-analyses evaluated the marginal adaptation and marginal discoloration in class II and V cavities, with a non-significant heterogeneity (I2 = 0%, p>0.05). The certainty of evidence was considered high, except for two subgroups of each outcome. Conclusion: There is evidence that composite restorations using conventional and bulk-fill resin composites present similar clinical performance related to marginal degradation.

A inclusão da Educação Financeira na Base Nacional Comum Curricular, principalmente na área de Matemática, requer que discussões sobre essa temática sejam realizadas na formação inicial e continuada de professores de Matemática, visando o preparo para a abordagem desse tema. Nesse sentido, objetivamos apresentar e discutir possíveis contribuições de monitorias relacionadas a Educação Financeira para a formação inicial de futuros professores de Matemática. Para tanto, consideramos ações realizadas no Curso de Licenciatura em Matemática da Universidade Estadual Paulista (Unesp), durante o primeiro semestre de 2020, em que as atividades se realizaram de modo remoto em decorrência da pandemia COVID-19. Por meio das atividades realizadas, apontamos a necessidade de estudos sobre Educação Financeira na formação inicial e continuada de professores de Matemática e contribuições de monitorias na formação de licenciandos.

Introduction: Burns are in fourth place as the most common type of trauma globally, generating a challenge due to the severity of patients' injuries. This study investigates the epidemiological profile of patients treated at the Burn Treatment Center (BTC) outpatient clinic of the Hospital Municipal do Tatuapé (HMT/SP). Methods: Data obtained from the outpatient records of the BTC outpatient clinic of the HMT/SP were analyzed from January 2019 to January 2020, using the following variables: gender, age, causal agent, burn extension, and affected region. Results: Higher predominance of burns in males (55.3%). There was a higher percentage in the population between 21 and 30 years (15.9%), followed closely by children under 10 years of age (15.8%). The leading causative agent was scalded/heated liquids (56.8%); followed by contact burn (14.7%), the vast majority of patients were affected by medium-sized burn (90.1%), i.e., between 11 and 20% of the burned body surface and the thorax/abdomen the most affected region. Conclusion: The epidemiological profile demonstrated in this study was compatible, in most data, with the profile found in other centers specialized in treating burns.

A doença renal crônica (DRC), enfermidade caracterizada pela inflamação túbulo-intersticial, atrofia tubular e fi-brose intersticial com perda progressiva da função renal, tem se tornado uma afecção relativamente comum em cães e gatos. Devido ao fato de o transplante renal ainda não ser uma opção viável na medicina veterinária, surgi-ram estudos para avaliar a possibilidade de tratamento de DRC com células-tronco mesenquimais (CTMs), em ra-zão dos efeitos anti-inflamatórios, anti-oxidantes, anti-fibróticos e imunomoduladores que essas células possuem. Onze pacientes portadores de DRC (6 cães e 5 gatos) foram avaliados e submetidos à terapia com CTMs halógenas. Todos os 5 gatos e 4 dos 6 cães tiveram diminuição nas taxas de creatinina sérica após o transplante de células, indicando que houve diminuição significativa para a creatinina em cães (p=0.0238). Houve, também, considerável diminuição na frequência de vômitos (p

Abstract The word venomics was coined to acknowledge the studies that use omics to investigate venom proteins and peptides. Venomics has evolved considerably over the last 20 years. The first works on scorpion or spider venomics were published in the early 2000’s. Such studies relied on peptide mass fingerprinting (PMF) to characterize venom complexity. After the introduction of new mass spectrometers with higher resolution, sensitivity and mass accuracy, and the next-generation nucleotide sequencing, the complexity of data reported in research on scorpion and spider venomics increased exponentially, which allowed more comprehensive studies. In the present review article, we covered key publications on scorpion venomics and spider venomics, presenting historical grounds and implemented technologies over the last years. The literature presented in this review was selected after searching the PubMed database using the terms “(scorpion venom) AND (proteome)” for scorpion venomics, and “(spider venom) AND (proteome)” for publications on spider venomics. We presented the key aspects related to proteomics in the covered papers including, but not restricted to, the employed proteomic strategy (i.e., PMF, two-dimensional gel electrophoresis, shotgun/bottom-up and/or top-down/peptidome), and the type of mass spectrometer used. Some conclusions can be drawn from the present study. For example, the scorpion genus Tityus is the most studied concerning venomics, followed by Centruroides; whereas for spiders the studied genera were found more equally distributed. Another interesting conclusion is the lack of high throughput studies on post-translational modifications (PTMs) of scorpion and spider proteins. In our opinion, PTMs should be more studied as they can modulate the activity of scorpion and spider toxins.

RESUMO (Caracterização genética no crescimento inicial de progênies de Eremanthus erythropappus (DC.) MacLeish em Aiuruoca, MG, Brasil). Eremanthus erythropappus (DC.) MacLeish é uma espécie nativa, apreciada economicamente devido a sua madeira e à extração de óleo essencial, cujo princípio ativo é o alfabisabolol, porém os estudos em melhoramento genético dessa espécie ainda são escassos. Objetivou-se com este trabalho avaliar a sobrevivência e estimar parâmetros genéticos em progênies de E. erythropappus em campo aos 15, 22 e 30 meses de idade. O experimento foi instalado na Fazenda Guapiara, em Aiuruoca, MG, onde foram plantadas mudas de 15 progênies em delineamento de blocos casualizados, com cinco repetições e seis plantas por parcela. Foram realizadas avaliações da altura das plantas e procederam-se aos estudos genéticos no software SELEGEN por meio do método REML/BLUP. Aos 30 meses, foi avaliado o percentual de sobrevivência das mudas. Verificou-se diferenças significativas entre as progênies, e as maiores estimativas de h2mp (0,48) e de Acprog (0,69) foram encontradas aos 30 meses. Portanto, mesmo em estágio juvenil, foi possível identificar variabilidade genética e analisar a sua expressão ao longo do tempo, o que possibilita dar continuidade aos estudos visando o melhoramento genético da espécie.

Arachnoid cysts are benign intracranial lesions. They are usually located in the middle fossa, but can be found in other locations. We present a case of symptomatic Meckel cave (MC) arachnoid cyst - a very rare location - and a treatment strategy not elsewhere described before for this condition. A 54-year-old female with trigeminal neuralgia with previous history of radiofrequency rhizotomy treatment 6 years before admission had been experiencing pain recurrence with progression, which required successive increases in carbamazepine dosage. Magnetic Resonance Imaging (MRI) showed dilatation of the right MC with extension to the petrous apex. The lesion was compatible with arachnoid cyst, and due to the worsening of the clinical condition, surgical treatment was chosen. Percutaneous puncture of the cyst through the foramen ovale with injection of intracystic fibrin sealant was performed. The patient woke up from anesthesia with pain improvement and was discharged asymptomatic the next day. After 12 months of follow-up, she remained pain-free. In the literature review, we found only eight cases reported as MC arachnoid cyst. These are likely to progress and become symptomatic owing to their communication with the subarachnoid space and a unidirectional valve mechanism. Pain improvement with this technique is probably secondary to the interruption of these mechanisms.

Este artigo visa analisar os índices obtidos na prova de 400 metros rasos por uma geração de militares (4.429 indivíduos, saudáveis, com idade 20 a 23 anos) que compuseram o segundo ano do Curso de Formação de Oficiais da Academia Militar das Agulhas Negras (AMAN) de 2009 a 2018, verificando estatisticamente as notas obtidas durante o teste físico. Para realizar esta análise foi utilizado o software BioEstat 5.0 e os dados foram coletados na Seção de Educação Física da AMAN. Os resultados do teste Kolmogorov – Smirnof apontaram que as notas de nenhuma das turmas respeitaram a uma normalidade estatística. O teste de Mann-Whitney indicou que não houve diferenças significativas entre as notas das turmas de 2009 e 2010; 2010 e 2011; 2011 e 2012; 2012 e 2013; 2013 e 2014; 2014 e 2015; 2016 e 2017. O mesmo teste indicou que há diferenças significativas entre as notas das turmas de 2015 e 2016 e entre a turma de 2017 e 2018. Houve uma diminuição significativa de 2015 para 2016 e um aumento considerável da média em 2018 em relaç

O objetivo do presente estudo foi comparar o efeito agudo do Turkish Get-Up (TGU) e do alongamento estático (AE) sobre a mobilidade articular de homens fisicamente ativos. Vinte estudantes universitários do sexo masculino participaram do presente estudo. Os sujeitos foram submetidos a um protocolo de AE que era composto por três diferentes movimentos realizados de forma unilateral com duração de 30 segundos em duas séries com intervalo de 30 segundos entre elas. O outro protocolo foi um exercício de estabilidade dinâmica que é denominado TGU que consiste em um exercício com kettlebell no qual o sujeito deve começar deitado e realizar uma transição até a posição em pé, estabilizando o kettlebell acima da cabeça em duas repetições para cada lado com intervalo de 30 segundos entre os lados. Os protocolos foram antecedidos de um pré-teste no banco de Wells com o registro da melhor tentativa de três oportunidades e de um pós-teste e os resultados comparados. Os protocolos foram realizados por meio de duas visitas com intervalo de uma semana entre elas. Os resultados demonstram que no AE a diferença média entre o pré-teste e pós-teste foi de 2,3cm, já para o TGU foi de 4cm. Dessa maneira, os dois protocolos foram capazes de melhorar a flexibilidade, porém o TGU foi superior ao AE.

Studying the causes of food waste and potential interventions for minimizing it is one of the main concerns of those who work with food on all levels. Food in the education sector, which includes dining halls in higher education institutions, is among the sectors that deserve attention, since its consumers generate significant amounts of food waste. There is still a lack of studies, however, addressing the problem of food waste in dining halls. The general objective of this study is to investigate food waste in a Brazilian university dining hall, and consumer perceptions of the meals. By means of a questionnaire, it was possible to investigate the main perceptions of consumers, and what might be behind the waste generated. Spearman’s correlation was performed in order to verify the correlation between consumer food waste and consumer perceptions as to the reasons behind the food waste that is generated. It was found that average waste was 68g/consumer. It was also observed that consumers who placed their food in trays wasted more food than those who chose to eat from a dish. All the collected information was used to propose potential interventions to reduce food waste in university dining halls.

Abstract: About one-third of the world's food production is lost or wasted annually at different stages of food supply chains (FSCs). Food loss usually occurs in the early stages of FSCs, while waste is more prevalent in their final stages. Thus, the main objectives of the present study were to investigate the causes of loss and waste, as well as strategies that can minimize them. Decreasing food waste in collective catering organizations, including university restaurants, is situated in the context of these concerns. In order to contribute to this discussion, the authors investigated the causes of wastage in university restaurants and possible interventions recommended in the literature to reduce it. A search considering the “food waste” and “university restaurant” constructs in five different databases found 352 publications related to the theme, of which 21 supported to answer the two questions that guided this search: Q1: “What are the causes that contribute to food waste in university restaurants?” and Q2: “What are the interventions that can be or are used in university restaurants to reduce food waste?” The literature search identified 13 causes (portion size; quality; price; emotion; palatability; preparation/cooking; menu; time; satiety; storage; service; overbuying; security) and 14 possible interventions (campaigns; trayless systems; waste management; portion size; quality; changing menus; planning; preordering; charity/donations; nutritional information; coercion; changing the dishes; preparation/cooking; storage). From this perspective, the present article provides a holistic view of food waste in university restaurants, in order to guide mitigation interventions and future research on this theme.