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2. Contributors

Author

Acampora, Gregory Alexander, primary, Ahmad, Zeba N., additional, Alpay, Menekse, additional, Alpert, Jonathan E., additional, Babadi, Baktash, additional, Baek, Ji Hyun, additional, Baig, Mizra, additional, Bains, Ashika, additional, Baker, Amanda Waters, additional, Baldi, Olivia, additional, Beach, Scott R., additional, Beck, BJ, additional, Beckwith, Noor, additional, Benedek, David M., additional, Beresin, Eugene V., additional, Biederman, Joseph, additional, Bird, Suzanne A., additional, Blais, Mark A., additional, Bosson, Rahel, additional, Brendel, Rebecca Weintraub, additional, Bui, Eric, additional, Camprodon, Joan A., additional, Capawana, Michael R., additional, Caplan, Jason P., additional, Carter, Christopher, additional, Cassano, Paolo, additional, Cather, Corinne, additional, Celano, Christopher M., additional, Chang, Trina E., additional, Charoenpong, Prangthip, additional, Chemali, Zeina N., additional, Chen, Justin, additional, Chopra, Amit, additional, Choukas, Nathaniel, additional, Chung, Sun Young, additional, Cohen, Jonah, additional, Cohen, Lee S., additional, Colvin, Mary K. (Molly), additional, Conteh, Nkechi, additional, Crain, Laura D., additional, Cremens, M. Cornelia, additional, Cusin, Cristina, additional, Dekel, Sharon, additional, Denysenko, Lex, additional, Dickerson, Bradford C., additional, Donovan, Abigail L., additional, Doorley, James, additional, Dougherty, Darin D., additional, Ducharme, Simon, additional, Eddy, Kamryn T., additional, Edersheim, Judith G., additional, Evanoff, Anastasia B., additional, Fava, Maurizio, additional, Finn, Christine T., additional, Fernandez-Robles, Carlos, additional, Fishel, Anne K., additional, Forchelli, Gina, additional, Freudenreich, Oliver, additional, Fricchione, Gregory L., additional, Friedman, Nora D.B., additional, Gatchel, Jennifer R., additional, Gelaye, Bizu, additional, Georgiopoulos, Anna M., additional, Ghaznavi, Sharmin, additional, Ginsburg, Richard, additional, Gold, Alexandra K., additional, Gordon, Christopher D., additional, Gray, Caroline A., additional, Greenberg, Donna B., additional, Greer, Joseph, additional, Hazen, Eric P., additional, Henry, Michael E., additional, Herman, John B., additional, Himes, Susan, additional, Hogan, Charlotte, additional, Holt, Daphne J., additional, Huffman, Jeffery C., additional, Huguenel, Brynn, additional, Ipek, Simay, additional, Irwin, Kelly Edwards, additional, Ivkovic, Ana, additional, Jacobs, Jamie, additional, Jagodnik, Kathleen M., additional, Jain, Felipe A., additional, Jankauskaite, Greta, additional, Januzzi, James L., additional, Jenike, Michael A., additional, Jenkins, Jonathan, additional, Johnson, Justin M., additional, Julian, John N., additional, Kamali, Masoud, additional, Kaneko, Yoshio A., additional, Katz, Tamar C., additional, Keuroghlian, Alex, additional, Keuthen, Nancy J., additional, Khoshbin, Shahram, additional, Kim, Hyun-Hee, additional, Kim, Youngjung R., additional, Koh, Katherine A., additional, Kohrman, Samuel I., additional, Kontos, Nicholas, additional, Lagomasino, Isabel T., additional, Leval, Rebecca, additional, Leveroni, Catherine, additional, Lim, Carol, additional, Luccarelli, James, additional, Madarasmi, Saira, additional, Madva, Elizabeth N., additional, McCoy, Thomas H., additional, Milosavljevic, Nada, additional, Mischoulon, David, additional, Miyares, Peyton, additional, Morelli, Leah W., additional, Rodriguez, Alejandra E. Morfin, additional, Murray, Evan D., additional, Murray, Helen Burton, additional, Nejad, Shamim H., additional, Newhouse, Amy L., additional, Nicolson, Stephen E., additional, Nierenberg, Andrew A., additional, Nisavic, Mladen, additional, Nonacs, Ruta M., additional, Öngür, Dost, additional, Onyeaka, Henry, additional, Orr, Scott P., additional, Ostacher, Michael J., additional, Pace-Schott, Edward F., additional, Papakostas, George I., additional, Paudel, Shreedhar, additional, Peay, Celeste, additional, Pederson, Aderonke Bamgbose, additional, Penava, Susan J., additional, Perez, David L., additional, Perlis, Roy H., additional, Peters, Amy T., additional, Pinsky, Elizabeth G., additional, Pollak, Lauren Norton, additional, Pollastri, Alisha R., additional, Post, Loren M., additional, Powell, Alicia D., additional, Prager, Laura M., additional, Praschan, Nathan, additional, Price, Bruce H., additional, Prince, Jefferson B., additional, Probert, Julia M., additional, Prom, Maria C., additional, Punko, Diana, additional, Rauch, Scott L., additional, Raviola, Giuseppe J., additional, Reilly-Harrington, Noreen A., additional, Ritchie, Elspeth Cameron, additional, Rivas-Vazquez, Rafael, additional, Robinson, Ellen M., additional, Roffman, Joshua L., additional, Rubin, David H., additional, Ruchensky, Jared R., additional, Salvi, Joshua D., additional, Sanders, Kathy M., additional, Sanders, Wesley M., additional, Schlozman, Steven C., additional, Schouten, Ronald, additional, Schuster, Randi, additional, Shafer, Linda C., additional, Sheets, Jennifer, additional, Sher, Yelizaveta, additional, Sherman, Janet Cohen, additional, Sinclair, Samuel Justin, additional, Smith, Felicia A., additional, Sockalingam, Sanjeev, additional, Sogg, Stephanie, additional, Sorg, Emily M., additional, Sprich, Susan E., additional, Stein, Michelle B., additional, Stern, Theodore A., additional, Stoler, Joan M., additional, Stone, Mira, additional, Surman, Craig B.H., additional, Sylvia, Louisa G., additional, Tanev, Kaloyan S., additional, Tayeb, Haythum O., additional, Taylor, John B., additional, Thom, Robyn P., additional, Thomas, Jennifer J., additional, Tillman, Emma M., additional, Traeger, Lara, additional, Trinh, Nhi-Ha, additional, Uchida, Mai, additional, Ulman, Kathleen Hubbs, additional, Valera, Eve M., additional, Van Alphen, Manjola U., additional, Vazquez, Rafael, additional, Viguera, Adele C., additional, Wang, Betty, additional, Weilburg, Jeffrey B., additional, Weinberg, Marc, additional, Weinstein, Sylvie J., additional, Weisholtz, Daniel, additional, Wilens, Timothy E., additional, Wilhelm, Sabine, additional, Winkelman, John W., additional, Wright, Christopher L., additional, Wynn, Gary H., additional, Yeung, Albert, additional, Zakhary, Lisa, additional, and Zambrano, Juliana, additional

Published
2025
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22. Diagnostic and demographic factors of pediatric and adult catatonia hospitalizations: A 2016–2020 National Inpatient Sample Study.

Author

Luccarelli, James, Kalinich, Mark, Fricchione, Gregory, Smith, Felicia, Beach, Scott R., and Smith, Joshua R.

Subjects
*LENGTH of stay in hospitals, *CONSULTATION-liaison psychiatry, *CHILD patients, *RESTRAINT of patients, *NEUROBEHAVIORAL disorders
Abstract

Objective: Catatonia is a neuropsychiatric disorder that can occur in patients of any age, but it is uncertain whether patient demographics or underlying diagnoses differ between pediatric and adult patients. This study investigates patients of all ages diagnosed with catatonia during acute care hospitalizations in the United States over a 5‐year period. Method: The National Inpatient Sample, an all‐payors database of acute care hospital discharges, was queried for patients with a discharge diagnosis of catatonia between 2016 and 2020 with patients stratified by age as pediatric (≤18 years) or adult (>18 years). Results: Among 174,776,205 hospitalizations recorded in the NIS from 2016 to 2020, 61,990 (95% CI: 60,257 to 63,723; 0.035%) involved a diagnosis of catatonia. Of these, 3255 were for pediatric patients and 58,735 were for adult patients. Compared with adult patients, pediatric catatonia patients were more likely to be male and non‐White. Diagnostically, psychotic disorders, encephalitis, and neurodevelopmental disorders were more common primary discharge diagnoses in pediatric patients, while adult patients more frequently were diagnosed with mood disorders. Length of stay was not significantly different between pediatric and adult catatonia hospitalizations. Physical restraints were commonly applied for patients with catatonia. Conclusion: Pediatric and adult catatonia patients differed in sex, race, and diagnosis, although hospital length of stay was not different between pediatric and adult catatonia hospitalizations. These results may inform catatonia diagnosis in the hospital setting and point to disparities that could be targets of quality improvement efforts. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Conformational control by intramolecular hydrogen bonding

Author

Luccarelli, James Walter and Hamilton, Andrew D.

Subjects
621.01575, Biophysical chemistry, Chemical biology, Computational chemistry, Computer aided molecular and material design, Chemistry & allied sciences, Organic chemistry, NMR spectroscopy, peptidomimetics, Grb2, Gab2, protein-protein interactions
Abstract

Hydrogen bonds are directional, non-covalent interactions between hydrogen and electronegative atoms. Although generally weak, these interactions are critical to the stability of many biological systems including proteins and DNA. This dissertation explores small molecules in which an intramolecular hydrogen bond is the key determinant of conformation. Chapter 1 introduces the protein Grb2 SH3C, details its role in cancer signalling, and delineates the idea of peptidomimetics—small molecules which are functionalized to mimic the structure of a peptide and disrupt protein-protein interactions. Chapter 2 describes a virtual screen for binders to Grb2 SH3C. From a library of 6.3 million compounds, 34 were tested in vitro and two found to bind to the protein in two orthogonal assays. Chapter 3 describes mimics of the polyproline II helix using a benzoylurea scaffold. A small library of these compounds was synthesized and tested for binding to Grb2 SH3C using SPR, a competition assay, and NMR. Chapter 4 describes attempts to mimic a 310 helix using benzamide-based peptidomimetics. The synthesis and in vitro evaluation of these molecules as ligands of Grb2 SH3C is described. Chapter 5 uses quantum chemical calculations to assess the energies of a series of molecular switches. These calculations benchmark a range of modern density functional theory calculations, and attempt to quantify the accuracy of these methods for a large, flexible system. The role of solvation, entropy, geometry, and torsional angles are assessed in accurately calculating the energies of the critical hydrogen bonds.

Published
2013

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