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1. Clinical and Ultrasonographic Remission in Bio-naïve and Bio-failure Patients with Rheumatoid Arthritis at 24 Weeks of Upadacitinib Treatment: The UPARAREMUS Real-Life Study

Author

Picchianti Diamanti, Andrea, Cattaruzza, Maria Sofia, Salemi, Simonetta, Di Rosa, Roberta, Sesti, Giorgio, De Lorenzo, Chiara, Felice, Gloria Maria, Frediani, Bruno, Baldi, Caterina, Chimenti, Maria Sole, D’Antonio, Arianna, Crepaldi, Gloria, Luchetti, Michele Maria, Paci, Valentino, Zabotti, Alen, Giovannini, Ivan, Canzoni, Marco, Sebastiani, Giandomenico, Scirocco, Chiara, Perricone, Carlo, Laganà, Bruno, and Iagnocco, Annamaria

Published
2024
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3. Worlds, Algorithms, and Niches: The Feedback-Loop Idea in Kuhn’s Philosophy

Author

De Benedetto, Matteo, Luchetti, Michele, Renn, Jürgen, Series Editor, Patton, Lydia, Series Editor, McLaughlin, Peter, Associate Editor, Divarci, Lindy, Managing Editor, Cohen, Robert S., Founding Editor, Gavroglu, Kostas, Editorial Board Member, Glick, Thomas F., Editorial Board Member, Heilbron, John, Editorial Board Member, Kormos-Buchwald, Diana, Editorial Board Member, Nieto-Galan, Agustí, Editorial Board Member, Ordine, Nuccio, Editorial Board Member, Simões, Ana, Editorial Board Member, Stachel, John J., Editorial Board Member, Zhang, Baichun, Editorial Board Member, and Shan, Yafeng, editor

Published
2024
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7. Theory Choice as Niche Construction: The Feedback Loop between Scientific Theories and Epistemic Values.

Author

De Benedetto, Matteo and Luchetti, Michele

Abstract

We focus on a neglected aspect of scientific theory choice: how the selection of theories affects epistemic values. Building on Kuhn, we provide a general characterization of the feedback-loop dynamic between theories and values in theory choice as analogous to the relationship between organisms and the environment in niche construction. We argue that understanding theory choice as niche construction can explain how certain values acquire more weight and a specific application over time, and how resistance to scientific change can, therefore, arise. We illustrate our picture by looking at the Mendelian–biometrician controversy. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Clinical and patient reported outcomes of the multidisciplinary management in patients with inflammatory bowel disease-associated spondyloarthritis

Author

Luchetti, Michele Maria, Benfaremo, Devis, Bendia, Emanuele, Bolognini, Laura, Fava, Giammarco, Marini, Francesco, Di Sario, Antonio, Ciferri, Monia, Di Nicola, Francesca, Marconi, Valentina, Perini, Lucia, Manfredi, Lucia, Pomponio, Giovanni, Mosca, Piergiorgio, Benedetti, Antonio, and Gabrielli, Armando

Published
2019
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18. Management of Concomitant Inflammatory Bowel Disease or Uveitis in Patients With Psoriatic Arthritis: An Updated Review Informing the 2021 GRAPPA Treatment Recommendations

Author

Jadon, Deepak R., primary, Corp, Nadia, additional, van der Windt, Danielle A., additional, Coates, Laura C., additional, Soriano, Enrique R., additional, Kavanaugh, Arthur, additional, Raine, Tim, additional, Rieder, Florian, additional, Siebert, Stefan, additional, Zummer, Michel, additional, Schwartzman, Sergio, additional, Rosenbaum, James T., additional, Michelsen, Brigitte, additional, Laxminarayan, Ramasharan, additional, Wu, Dongze, additional, Gupta, Latika, additional, Ng, Beverly, additional, Jethwa, Hannah, additional, De Windt, Nick, additional, Gudu, Tania, additional, Hutton, Joseph, additional, O'Sullivan, Denis, additional, Luchetti, Michele M., additional, Stoll, Matthew, additional, Singh, Jasvinder A., additional, Peluso, Rosario, additional, Rademacher, Judith, additional, and Husni, M. Elaine, additional

Published
2022
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19. Specialisation by Value Divergence: The Role of Epistemic Values in the Branching of Scientific Disciplines.

Author

De Benedetto, Matteo and Luchetti, Michele

Subjects
*VALUES (Ethics), *GENETIC speciation, *MOLECULAR biology, *ANALOGY
Abstract

According to Kuhn's speciation analogy, scientific specialisation is fundamentally analogous to biological speciation. In this paper, we extend Kuhn's original language-centred formulation of the speciation analogy, to account for episodes of scientific specialisation centred around methodological differences. Building upon recent views in evolutionary biology about the process of speciation by genetic divergence, we will show how these methodology-centred episodes of scientific specialisation can be understood as cases of specialisation driven by value divergence. We will apply our model of specialisation by value divergence to an episode of methodology-centred scientific specialisation: the emergence of molecular biology. [ABSTRACT FROM AUTHOR]

Published
2023
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22. An Italian Disease-Based Registry of Axial and Peripheral Spondyloarthritis: The SIRENA Study

Author

Zabotti, Alen, primary, Luchetti, Michele Maria, additional, Selmi, Carlo Francesco, additional, Ramonda, Roberta, additional, Grembiale, Rosa Daniela, additional, Dagna, Lorenzo, additional, D'Angelo, Salvatore, additional, Cafaro, Giacomo, additional, De Vita, Salvatore, additional, Felicetti, Mara, additional, Marelli, Silvia, additional, Frigerio, Daniela, additional, and Favalli, Ennio Giulio, additional

Published
2021
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23. Management of Concomitant Inflammatory Bowel Disease or Uveitis in Patients with Psoriatic Arthritis: An Updated Review Informing the 2021 GRAPPA Treatment Recommendations

Author

Jadon, Deepak R., Corp, Nadia, van der Windt, Danielle A., Coates, Laura C., Soriano, Enrique R., Kavanaugh, Arthur, Raine, Tim, Rieder, Florian, Siebert, Stefan, Zummer, Michel, Schwartzman, Sergio, Rosenbaum, James T., Michelsen, Brigitte, Laxminarayan, Ramasharan, Wu, Dongze, Gupta, Latika, Ng, Beverly, Jethwa, Hannah, De Windt, Nick, Gudu, Tania, Hutton, Joseph, O’Sullivan, Denis, Luchetti, Michele M., Stoll, Matthew, Singh, Jasvinder A., Peluso, Rosario, Rademacher, Judith, and Husni, M. Elaine

Abstract

ObjectiveSeveral advanced therapies have been licensed across the related conditions of psoriatic arthritis (PsA), Crohn disease (CD), ulcerative colitis (UC), and noninfectious uveitis. We sought to summarize results from randomized controlled trials (RCTs) investigating the efficacy and safety of advanced therapies for these related conditions in patients with PsA.MethodsWe updated the previous systematic search conducted in 2013 with literature reviews of MEDLINE, Embase, and the Cochrane Library (from February 2013 to August 2020) on this subject; only those new studies are presented here. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework.ResultsThe number of RCTs meeting eligibility criteria were 12 for CD, 15 for UC, and 5 for uveitis. The tumor necrosis factor inhibitor (TNFi) class appears to be efficacious and safe across CD, UC, and uveitis, with the exception of etanercept. Interleukin 12/23 inhibitors (IL-12/23i) are efficacious for CD and UC. Phase II and III RCTs of Janus kinase inhibitors (JAKi) and IL-23i in CD and UC are promising in terms of efficacy and safety. IL-17i must be used with great caution in patients with PsA at high risk of inflammatory bowel disease (IBD). RCTs in uveitis have mainly studied adalimumab.ConclusionWe have identified 32 recent RCTs in IBD and uveitis and updated recommendations for managing patients with PsA and these related conditions. A multispecialty approach is essential to effectively, safely, and holistically manage such patients. Advanced therapies are not equally efficacious across these related conditions, with dosing regimens and safety varying.

Published
2023
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25. Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications

Author

Pagnini, Cristiano, primary, Picchianti-Diamanti, Andrea, additional, Bruzzese, Vincenzo, additional, Lorenzetti, Roberto, additional, Luchetti, Michele Maria, additional, Martin Martin, Louis Severino, additional, Pica, Roberta, additional, Scolieri, Palma, additional, Scribano, Maria Lia, additional, Zampaletta, Costantino, additional, Chimenti, Maria Sole, additional, and Lagana, Bruno, additional

Published
2021
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26. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis

Author

Baroni, Silvia Svegliati; Santillo, Mariarosaria; Bevilacqua, Federica, Luchetti, Michele; Spadoni, Tatiana; Mancini, Matteo; Fraticelli, Paolo, Sambo, Paola; Funaro, Ada; Kazlauskas, Andrius, and Avvedimento, Enrico V.; Gabrielli, Armando

Subjects
Platelet-derived growth factor -- Health aspects, Gene expression -- Research, Scleroderma (Disease) -- Genetic aspects, Systemic scleroderma -- Genetic aspects
Abstract

The hypothesis that patients with scleroderma have serum autoantibodies that stimulate the platelet-derived growth factor (PDGF) receptor (PDGFR), activating collagen-gene expression is tested. The purification of anti-PDGFR reactive oxygen species (ROS)-stimulating antibodies and the results of tests of their biologic activity as purified clones strongly argue that these antibodies have a causal role in the pathogenesis of scleroderma.

Published
2006

28. Corrigendum to: Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis

Author

Luchetti, Michele Maria, primary, Ciccia, Francesco, additional, Avellini, Chiara, additional, Benfaremo, Devis, additional, Rizzo, Aroldo, additional, Spadoni, Tatiana, additional, Svegliati, Silvia, additional, Marzioni, Daniela, additional, Santinelli, Alfredo, additional, Costantini, Andrea, additional, Viola, Nadia, additional, Berretta, Antonella, additional, Ciferri, Monia, additional, Mattioli Belmonte Cima, Monica, additional, Mosca, Piergiorgio, additional, Benedetti, Antonio, additional, and Gabrielli, Armando, additional

Published
2020
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30. Skin involvement in SARS‐CoV‐2 infection: Case series

Author

Diotallevi, Federico, primary, Campanati, Anna, additional, Bianchelli, Tommaso, additional, Bobyr, Ivan, additional, Luchetti, Michele Maria, additional, Marconi, Barbara, additional, Martina, Emanuela, additional, Radi, Giulia, additional, and Offidani, Annamaria, additional

Published
2020
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31. Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis

Author

Luchetti, Michele Maria, primary, Ciccia, Francesco, additional, Avellini, Chiara, additional, Benfaremo, Devis, additional, Rizzo, Aroldo, additional, Spadoni, Tatiana, additional, Svegliati, Silvia, additional, Marzioni, Daniela, additional, Santinelli, Alfredo, additional, Costantini, Andrea, additional, Viola, Nadia, additional, Berretta, Antonella, additional, Ciferri, Monia, additional, Mattioli Belmonte Cima, Monica, additional, Mosca, Piergiorgio, additional, Benedetti, Antonio, additional, and Gabrielli, Armando, additional

Published
2020
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32. FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

Author

Ramadori, Giorgio, primary, Ioris, Rafael M., additional, Villanyi, Zoltan, additional, Firnkes, Raquel, additional, Panasenko, Olesya O., additional, Allen, George, additional, Konstantinidou, Georgia, additional, Aras, Ebru, additional, Brenachot, Xavier, additional, Biscotti, Tommasina, additional, Charollais, Anne, additional, Luchetti, Michele, additional, Bezrukov, Fedor, additional, Santinelli, Alfredo, additional, Samad, Muntaha, additional, Baldi, Pierre, additional, Collart, Martine A., additional, and Coppari, Roberto, additional

Published
2020
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33. Enteropathic spondyloarthritis: Results from a large nationwide database analysis

Author

Picchianti-Diamanti, Andrea, primary, Lorenzetti, Roberto, additional, Chimenti, Maria Sole, additional, Luchetti, Michele Maria, additional, Conigliaro, Paola, additional, Canofari, Claudia, additional, Benfaremo, Devis, additional, Bruzzese, Vincenzo, additional, Laganà, Bruno, additional, Perricone, Roberto, additional, Zullo, Angelo, additional, Caso, Francesco, additional, Costa, Luisa, additional, Tomietto, Paola, additional, Fabio, Fischetti, additional, Scolieri, Palma, additional, Navarini, Luca, additional, Cuccagna, Elisa, additional, Severino Martin-Martin, Luis, additional, Lia Scribano, Maria, additional, Faggiani, Roberto, additional, Pagnini, Cristiano, additional, Mocci, Giammarco, additional, Demurtas, Mauro, additional, Tursi, Antonio, additional, Festa, Stefano, additional, Zerboni, Giulia, additional, Pica, Roberta, additional, Ridola, Lorenzo, additional, Paroli, Marino, additional, Baccini, Flavia, additional, Baincone, Livia, additional, Gabrielli, Armando, additional, Afeltra, Antonella, additional, and Scarpa, Raffaele, additional

Published
2020
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35. Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs

Author

Benfaremo, Devis, Luchetti, Michele Maria, and Gabrielli, Armando

Subjects
Article Subject
Abstract

Inflammatory bowel disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. Since inflammatory bowel disease-associated spondyloarthritis has been associated with a significant diagnostic delay, which may lead to poor quality of life and progression of joint damage, efforts to discover new reliable and noninvasive diagnostic biomarkers have been made. We reviewed the state of the art of biomarker research in inflammatory bowel disease-associated spondyloarthritis, showing that to date it has been largely unsatisfactory. Only a few of the biomarkers that have been investigated are likely to enter the clinical practice upon further validation in independent cohorts. The research of new and innovative biomarkers for inflammatory bowel disease-associated spondyloarthritis is warranted.

Published
2019
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42. Multicenter Validation of the DETAIL Questionnaire for the Screening of Spondyloarthritis in Patients With Inflammatory Bowel Diseases.

Author

Benfaremo, Devis, Luchetti, Michele Maria, Di Carlo, Marco, Laganà, Bruno, Picchianti-Diamanti, Andrea, Carubbi, Francesco, Pica, Roberta, Chimenti, Maria Sole, Lorenzetti, Roberto, Scolieri, Palma, Bruzzese, Vincenzo, Benedetti, Antonio, Ramonda, Roberta, Giacomelli, Roberto, Salaffi, Fausto, Gabrielli, Armando, and GRADES-IBD Study Group

Published
2021
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43. Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis.

Author

Luchetti, Michele Maria, Ciccia, Francesco, Avellini, Chiara, Benfaremo, Devis, Rizzo, Aroldo, Spadoni, Tatiana, Svegliati, Silvia, Marzioni, Daniela, Santinelli, Alfredo, Costantini, Andrea, Viola, Nadia, Berretta, Antonella, Ciferri, Monia, Cima, Monica Mattioli Belmonte, Mosca, Piergiorgio, Benedetti, Antonio, and Gabrielli, Armando

Subjects
*BACTERIAL physiology, *ENZYME-linked immunosorbent assay, *EPITHELIUM, *FLOW cytometry, *ILEUM, *IMMUNE system, *INFLAMMATORY bowel diseases, *INTESTINAL mucosa, *POLYMERASE chain reaction, *SPONDYLOARTHROPATHIES, *STAINS & staining (Microscopy), *GUT microbiome, *LIPOPOLYSACCHARIDES, *DISEASE complications, *DISEASE risk factors
Abstract

Objectives Gut microbiota has been widely reported to be involved in systemic inflammation through microbial translocation and T cell activation in several diseases. In this work we aimed to investigate bacterial infiltration and epithelial impairment in the gut of patients with IBD-associated SpA (SpA-IBD), as well as the relationship of microbial translocation with immune system activation and their putative role in the pathogenesis of joint inflammation in IBD patients. Methods Tight-junction proteins (TJPs) occludin and claudin-1/-4 and bacteria were assessed by real-time PCR analysis and immunohistochemical staining of the ileum. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharides (LPS), soluble CD14 (sCD14), sclerostin and anti-sclerostin antibodies (anti-sclerostin-IgG) were assayed with ELISAs and peripheral mononuclear blood cells with flow cytometry. LPS and sCD14 were used in vitro to stimulate a human osteoblast cell line. Results Compared with IBD, ileal samples from SpA-IBD patients showed bacterial infiltration, epithelial damage and downregulation of TJPs. In sera, they showed higher serum levels of I-FABP, LPS, sCD14 (the latter correlating with sclerostin and anti-sclerostin-IgG) and higher CD80+/CD163+ and lower CD14+ mononuclear cells. In vitro experiments demonstrated that only the LPS and sCD14 synergic action downregulates sclerostin expression in osteoblast cells. Conclusion SpA-IBD patients are characterized by gut epithelium impairment with consequent translocation of microbial products into the bloodstream, immune system activation and an increase of specific soluble biomarkers. These findings suggest that gut dysbiosis could be involved in the pathogenesis of SpA-IBD and it could hopefully prompt the use of these biomarkers in the follow-up and management of IBD patients. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Induction of Scleroderma Fibrosis in Skin-Humanized Mice by Administration of Anti−Platelet-Derived Growth Factor Receptor Agonistic Autoantibodies

Author

Luchetti, Michele M, Moroncini, Gianluca, Jose Escamez, Maria, Svegliati Baroni, Silvia, Spadoni, Tatiana, Grieco, Antonella, Paolini, Chiara, Funaro, Ada, AVVEDIMENTO, VITTORIO ENRICO, Larcher, Fernando, Del Rio, Marcela, Gabrielli, Armando, Luchetti, Michele M, Moroncini, Gianluca, Jose Escamez, Maria, Svegliati Baroni, Silvia, Spadoni, Tatiana, Grieco, Antonella, Paolini, Chiara, Funaro, Ada, Avvedimento, VITTORIO ENRICO, Larcher, Fernando, Del Rio, Marcela, and Gabrielli, Armando

Subjects
Rheumatology, Immunology, Immunology and Allergy
Abstract

To describe a skin-SCID mouse chimeric model of systemic sclerosis (SSc; scleroderma) fibrosis based on engraftment of ex vivo-bioengineered skin using skin cells derived either from scleroderma patients or from healthy donors.

Published
2016

46. Abnormal liver function tests predict transfer to intensive care unit and death in COVID‐19.

Author

Piano, Salvatore, Dalbeni, Andrea, Vettore, Elia, Benfaremo, Devis, Mattioli, Massimo, Gambino, Carmine G., Framba, Viviana, Cerruti, Lorenzo, Mantovani, Anna, Martini, Andrea, Luchetti, Michele M., Serra, Roberto, Cattelan, Annamaria, Vettor, Roberto, and Angeli, Paolo

Subjects
COVID-19, LIVER function tests, INTENSIVE care units, ACUTE kidney failure, HOSPITAL admission & discharge
Abstract

Background: The pandemic of coronavirus disease 2019 (COVID‐19) has emerged as a relevant threat for humans worldwide. Abnormality in liver function tests (LFTs) has been commonly observed in patients with COVID‐19, but there is controversy on its clinical significance. The aim of this study was to assess the prevalence, the characteristics and the clinical impact of abnormal LFTs in hospitalized, non‐critically ill patients with COVID‐19. Methods: In this multicentre, retrospective study, we collected data about 565 inpatients with COVID‐19. Data on LFTs were collected at admission and every 7 ± 2 days during the hospitalization. The primary outcome was a composite endpoint of death or transfer to intensive care unit (ICU). Results: Upon admission 329 patients (58%) had LFTs abnormality. Patients with abnormal LFTs had more severe inflammation and higher degree of organ dysfunction than those without. During hospitalization, patients with abnormal LFTs had a higher rate of transfer to ICU (20% vs 8%; P <.001), acute kidney injury (22% vs 13%, P =.009), need for mechanical ventilation (14% vs 6%; P =.005) and mortality (21% vs 11%; P =.004) than those without. In multivariate analysis, patients with abnormal LFTs had a higher risk of the composite endpoint of death or transfer to ICU (OR = 3.53; P <.001). During the hospitalization, 86 patients developed de novo LFTs abnormality, which was associated with the use of tocilizumab, lopinavir/ritonavir and acetaminophen and not clearly associated with the composite endpoint. Conclusions: LFTs abnormality is common at admission in patients with COVID‐19, is associated with systemic inflammation, organ dysfunction and is an independent predictor of transfer to ICU or death. [ABSTRACT FROM AUTHOR]

Published
2020
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