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4 results on '"Lucia Perez-Cebey"'

1. Left ventricular torsion and circumferential strain responses to exercise in patients with ischemic coronary artery disease

Author

Dolores Martínez, Gabriel Sanchez-Fernandez, Cayetana María Barbeito, Javier Broullon, Jesús Peteiro, Lucia Perez-Cebey, Alberto Bouzas-Mosquera, and José Manuel Vázquez-Rodríguez

Subjects
Male, medicine.medical_specialty, Myocardial Ischemia, Torsion, Mechanical, Ischemia, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, Circumferential strain, Radiology, Nuclear Medicine and imaging, In patient, 030212 general & internal medicine, Exercise, Cardiac imaging, Aged, business.industry, Middle Aged, medicine.disease, Adaptation, Physiological, Myocardial Contraction, Exercise echocardiography, Biomechanical Phenomena, Case-Control Studies, Exercise Test, Cardiology, Female, Stress, Mechanical, Ventricular torsion, Cardiology and Cardiovascular Medicine, business, Echocardiography, Stress
Abstract

LV torsion during exercise in patients with coronary artery disease (CAD) is not well known. Circumferential strain (CS) and left ventricular (LV) torsion (Tor) have not been evaluated during ischemia in these patients. We aimed to assess the effect of ischemia during exercise echocardiography (ExE) on CS and Tor. We studied a group of 73 patients with true positive ExE results (Ischemic group: ischemia plus an abnormal coronary angiogram) and a matched control group of 66 patients with negative ExE and either normal coronary angiography or low post-test probability of CAD. Basal rotation (Rot) and apical rotation and basal and apical CS were studied by speckle tracking at rest and exercise. Apical CS and apical and basal Rot values were similar between groups at rest, except basal CS which was already worse in the ischemic group. At exercise, all rotational and CS parameters were impaired in the ischemic in comparison with the control group (basal CS: −18 ± 5 vs. −25 ± 7 %, p

Published
2016
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2. Outcome by Exercise Echocardiography in Patients with Low Pretest Probability of Coronary Artery Disease

Author

Alberto Bouzas-Mosquera, José Manuel Vázquez-Rodríguez, Lucia Perez-Cebey, Javier Broullon, Juan C. Yáñez, Dolores Martínez, Jesús Peteiro, and Gabriel Sanchez-Fernandez

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Population, Myocardial Ischemia, Comorbidity, Coronary Artery Disease, 030204 cardiovascular system & hematology, Revascularization, Risk Assessment, Sensitivity and Specificity, Coronary artery disease, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Internal medicine, Outcome Assessment, Health Care, Prevalence, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, education, Retrospective Studies, education.field_of_study, Ejection fraction, business.industry, Reproducibility of Results, Percutaneous coronary intervention, Middle Aged, Prognosis, medicine.disease, Survival Rate, Pre- and post-test probability, Death, Sudden, Cardiac, Treatment Outcome, Spain, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Mace, Echocardiography, Stress
Abstract

Recommendations for testing in patients with low pretest probability of coronary artery disease differ in guidelines from no testing at all to different tests. The aim of this study was to assess the value of exercise echocardiography (ExE) to define outcome in this population.A retrospective analysis was conducted of 1,436 patients with low pretest probability of coronary artery disease (15%) who underwent initial ExE. Overall mortality, major adverse cardiac events (MACEs), defined as cardiac death or nonfatal myocardial infarction, and revascularization during follow-up, were assessed. Ischemia (development of new wall motion abnormalities with exercise) and fixed wall motion abnormalities were measured.The mean age was 50 ± 12 years. Resting wall motion abnormalities were seen in 13 patients (0.9%) and ischemia in 108 (7.5%). During follow-up, 38 patients died, 10 of cardiac death (annualized death rate, 0.39%); 20 patients had MACEs (annualized MACE rate, 0.21%); and 48 patients (29 with ischemia) underwent revascularization (annualized revascularization rate, 0.51%). The number and percentage of MACEs in the abnormal and normal ExE groups were similar (two [1.7%] vs 18 [1.4%], P = .70), as was the annualized MACE rate (0.31% vs 0.21%, P = .50). Peak left ventricular ejection fraction exhibited a nonsignificant trend for predicting MACEs (P = .11). The number of studies needed to detect an abnormal finding was 12.6 and to detect a patient with extensive ischemia was 26.1.ExE offers limited prognostic information in patients with low pretest probability of coronary artery disease. The small number of abnormal findings on ExE and low event rates and the large number of studies needed to detect an abnormal finding limit further the value of imaging in this population.

Published
2016
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3. Impacto del tiempo de intervención en pacientes con IAMSEST: diseño del estudio IMPACT-TIMING-GO

Author

Felipe Díez-Delhoyo, Pablo Díez-Villanueva, María Thiscal López Lluva, María Abellas, Ignacio Amat-Santos, Pablo Bazal-Chacón, Anna Carrasquer, Miguel Corbí, David Escribano, Ane Elorriaga, Sergio García-Blas, Teresa Giralt-Borrell, Alfonso Jurado-Román, Isaac Llaó, Lucía Matute-Blanco, Martín Negreira-Caamaño, Lucía Pérez-Cebey, Ricardo Rivera-López, Carolina Robles-Gamboa, Pablo Salinas, Fernando José Torres Mezcúa, Iván Olavarri-Miguel, Jessica Vaquero-Luna, and Pedro Cepas-Guillén

Subjects
Síndrome coronario agudo, Infarto agudo de miocardio, Síndrome coronario agudo sin elevación del segmento ST, Doble antiagregación plaquetaria, Pretratamiento, Coronariografía precoz, Guía ESC, Diabetes mellitus, Hemorragia, Revascularización, Internal medicine, RC31-1245
Abstract

RESUMEN Introducción y objetivos: El momento óptimo para la realización de un cateterismo diagnóstico en pacientes con síndrome coronario agudo sin elevación del segmento ST (SCASEST) y la necesidad de pretratamiento con doble antiagregación son motivo de controversia. Este estudio pretende conocer el abordaje diagnóstico y terapéutico actual, así como la evolución clínica de los pacientes con SCASEST en España. Métodos: El estudio IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation. ManaGement and Outcomes (IMPACT-TIMING-GO) es un registro nacional observacional, prospectivo y multicéntrico, que incluirá pacientes consecutivos con diagnóstico de SCASEST tratados con coronariografía diagnóstica y que presenten enfermedad coronaria aterosclerótica inestable o causal en 24 centros españoles. El objetivo primario del estudio es conocer el grado de cumplimiento de las recomendaciones de las guías de práctica clínica en pacientes que ingresan por SCASEST tratados con coronariografía en España, describir el uso del tratamiento antitrombótico antes del cateterismo y determinar el tiempo hasta este en la práctica clínica real. Se describirán también los eventos adversos cardiovasculares mayores: mortalidad por cualquier causa, infarto no fatal e ictus no fatal, y también la incidencia de hemorragia mayor según la escala BARC (Bleeding Academic Research Consortium) durante el seguimiento a 1 y 3 años. Resultados: Este registro permitirá mejorar el conocimiento en relación con el abordaje terapéutico inicial en pacientes que ingresan por SCASEST en España. Contribuirá a conocer sus características basales y su evolución clínica, así como el grado de adherencia y cumplimiento de las recomendaciones de las que se dispone actualmente. Conclusiones: Se trata del primer estudio prospectivo realizado en España que permitirá conocer las estrategias terapéuticas iniciales, tanto farmacológicas como intervencionistas, que se realizan en nuestro país en pacientes con SCASEST tras la publicación de las guías europeas de 2020, y la evolución clínica de estos pacientes a corto y largo plazo.

Published
2023
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4. Impact of time of intervention in patients with NSTEMI. The IMPACT-TIMING-GO trial design

Author

Felipe Díez-Delhoyo, Pablo Díez-Villanueva, María Thiscal López Lluva, María Abellas, Ignacio Amat-Santos, Pablo Bazal-Chacón, Anna Carrasquer, Miguel Corbí, David Escribano, Ane Elorriaga, Sergio García-Blas, Teresa Giralt-Borrell, Alfonso Jurado-Román, Isaac Llaó, Lucía Matute-Blanco, Martín Negreira-Caamaño, Lucía Pérez-Cebey, Ricardo Rivera-López, Carolina Robles-Gamboa, Pablo Salinas, Fernando José Torres Mezcúa, Iván Olavarri-Miguel, Jessica Vaquero-Luna, and Pedro Cepas-Guillén

Subjects
Acute coronary syndrome, Acute myocardial infarction, Non-ST-segment elevation acute coronary syndrome, Dual antiplatelet therapy, Pretreatment, Early invasive strategy, ESC guidelines, Diabetes mellitus, Hemorrhage, Revascularization, Medicine
Abstract

ABSTRACT Introduction and objectives: The optimal time to perform a diagnostic coronary angiography in patients admitted due to non-ST-segment elevation acute coronary syndrome (NSTEACS) and start pretreatment with dual antiplatelet therapy is controversial. Our study aims to identify the current diagnostic and therapeutic approach, and clinical progression of patients with NSTEACS in our country. Methods: The IMPACT-TIMING-GO trial (Impact of time of intervention in patients with myocardial infarction with non-ST segment elevation. Management and outcomes) is a national, observational, prospective, and multicenter registry that will include consecutive patients from 24 Spanish centers with a clinical diagnosis of NSTEACS treated with diagnostic coronary angiography and with present unstable or causal atherosclerotic coronary artery disease. The study primary endpoint is to assess the level of compliance to clinical practice guidelines in patients admitted due to NSTEACS undergoing coronary angiography in Spain, describe the use of antithrombotic treatment prior to cardiac catheterization, and register the time elapsed until it is performed. Major adverse cardiovascular events will also be described like all-cause mortality, non-fatal myocardial infarction and non-fatal stroke, and the rate of major bleeding according to the BARC (Bleeding Academic Research Consortium) scale at 1- and 3-year follow-up. Results: This study will provide more information on the impact of different early management strategies in patients admitted with NSTEACS in Spain, and the degree of implementation of current recommendations into the routine clinical practice. It will also provide information on these patients’ baseline and clinical characteristics. Conclusions: This is the first prospective study conducted in Spain that will be reporting on the early therapeutic strategies—both pharmacological and interventional—implemented in our country in patients with NSTEACS after the publication of the 2020 European guidelines, and on the clinical short- and long-term outcomes of these patients.

Published
2023
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