1. Success of Testicular Sperm Injection and Intracytoplasmic Sperm Injection in Men with Klinefelter Syndrome
- Author
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Gianpiero D. Palermo, Peter N. Schlegel, Marc Goldstein, Zev Rosenwaks, Jonathan D. Schiff, and Lucinda L. Veeck
- Subjects
Azoospermia ,endocrine system ,medicine.medical_specialty ,In vitro fertilisation ,urogenital system ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Biochemistry (medical) ,Clinical Biochemistry ,Semen ,Biology ,medicine.disease ,Biochemistry ,Sperm ,Testicular sperm extraction ,Intracytoplasmic sperm injection ,Andrology ,Endocrinology ,Internal medicine ,Sperm Retrieval ,medicine ,Klinefelter syndrome ,reproductive and urinary physiology - Abstract
Purpose: The aim of this study was to report the successful fertility treatment of men with Klinefelter syndrome using testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). Methods: A total of 42 men with Klinefelter syndrome who underwent 54 TESE procedures were identified. Before TESE, patients with serum testosterone levels less than 15.6 nmol/liter were treated with an aromatase inhibitor. Sperm retrieval rates and results of ICSI, including fertilization and clinical pregnancy, were collected. Results: Mean pretreatment FSH and testosterone levels were 33.2 IU/liter and 9.8 nmol/liter. During medical therapy, the mean testosterone level rose to 17.0 nmol/liter (P < 0.01). Spermatozoa were found during 39 microdissection TESE procedures, on the day before, or day of oocyte retrieval during a programmed in vitro fertilization cycle. The sperm retrieval rate was 72% (39 of 54) per TESE attempt, and 29 of the 42 different men (69%) had adequate sperm found for ICSI. Thirty-three...
- Published
- 2005