154 results on '"Luigi Pellegrino"'
Search Results
2. La ricerca del Collettivo Bohob su Catania: frammenti 'squisiti'
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Laura La Rosa, Luigi Pellegrino, and Matteo Pennisi
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archeologia ,città ,progetto ,Catania ,disegno ,Drawing. Design. Illustration ,NC1-1940 ,Visual arts ,N1-9211 - Abstract
Il contributo indaga la ricerca che il Collettivo di architettura Bohob sta portando avanti sulla città di Catania attraverso due binari paralleli: il disegno della città e i progetti minimi, tenuti insieme dal disegno d’architettura inteso come strumento cardine della disciplina architettonica. La Pianta topografica della città di Catania di Sebastiano Ittar del 1832 rappresenta una città in cui un nuovo impianto è pregiudicato dal permanere di frammenti antichi. Questa è la base teorica sulla quale fondare il disegno della città del collettivo Bohob, con l’obiettivo di elaborare un disegno in continuità con l’idea di Ittar, proponendo uno scarto minimo ma decisivo. I progetti minimi nascono dall’esigenza di costruire luoghi urbani in prossimità delle aree archeologiche nel centro di Catania, attualmente percepite come marginali. Consistono in una famiglia di preziose teche elaborate attraverso il trittico, un metodo di disegno che tiene insieme simultaneamente tre scale: la planimetria 1:200, la scala della città; la pianta 1:50, la scala dell’edificio; la sezione-prospetto 1:10, la scala del costrutto architettonico. Al trittico, come appendice necessaria, si aggiunge la vista, non tanto la simulazione di una realtà futura ma la rappresentazione evocativa dell’idea alla base del progetto: la città, l’archeologia e il progetto minimo sulla soglia fra le due.
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- 2023
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3. Safe Robotized Polishing of Plastic Optical Fibers for Plasmonic Sensors.
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Francesco Arcadio, Marco Costanzo, Giulio Luongo, Luigi Pellegrino, Nunzio Cennamo, and Ciro Natale
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- 2022
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4. Near zero vascular complications using echo‐guided puncture during catheter ablation of arrhythmias: A retrospective study and literature review
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Pier Luigi Pellegrino, Antonio Di Monaco, Francesco Santoro, Massimo Grimaldi, Girolamo D'Arienzo, Grazia Casavecchia, Riccardo Ieva, Matteo Di Biase, Massimo Iacoviello, and Natale Daniele Brunetti
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cardiac arrhythmias ,catheter ablation ,ultrasound‐guided vascular puncture ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Catheter ablation (CA) is routinely used for the treatment of arrhythmias. Vascular complications are the most common complications during these procedures. Previous data reported that ultrasound (US)‐guided puncture is a useful method to avoid vascular complications. We reported our experience using US‐guided puncture in patients undergoing CA for arrhythmias. Methods A total of 273 patients (mean age 57 ± 17 years; 58% male) were referred to our center for CA of arrhythmias from January 2016 to December 2019. All procedures were performed by expert operators, and US‐guided vascular access was performed on all patients. Doppler sonography was performed the day after the procedure on all patients. Results Eighty‐four patients (31%) underwent atrioventricular nodal reentrant tachycardia ablation, 49 patients (18%) atrioventricular reentrant tachycardia ablation, 14 patients (5%) atrial tachycardia ablation, 25 patients (9%) atrial flutter ablation, 63 patients (23%) atrial fibrillation ablation, and 38 patients (14%) ventricular tachycardia ablation. Vascular pseudo‐aneurysms and arteriovenous fistula were defined as major complications; furthermore, venous thrombosis and inguinal hematomas were as defined minor complications. The percentage of major vascular complications was 0.3% (1 arteriovenous fistula) and the percentage of minor vascular complications was 0.3% (1 venous thrombosis). Discussion Ultrasound‐guided vascular puncture in patients undergoing CA is useful to improve procedural success and reduce complications.
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- 2022
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5. Application of a Testing Chain Methodology for Improving Power Converter Controllers.
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Merkebu Z. Degefa, Henning Taxt, Luigi Pellegrino, Julia Merino, Adrian Jimenez, Anand Narayan, Catalin Gavriluta, and Thomas I. Strasser
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- 2020
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6. Biomass-Based Renewable Energy Community: Economic Analysis of a Real Case Study
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Francesca Ceglia, Elisa Marrasso, Carlo Roselli, Maurizio Sasso, Guido Coletta, and Luigi Pellegrino
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smart energy community ,renewable energy community ,biomass-based cogeneration system ,district heating network ,Technology - Abstract
Renewable energy communities are catalysts of social innovation, the citizens’ engagement in energy actions, and the exploitation of local resources. Thus, this paper defines a model for analyzing and optimally sizing energy systems serving renewable energy communities. Then, the proposed and replicable model was tailored to the economic feasibility analysis of a renewable energy community in the municipality of Tirano (Northern Italy). An energy audit was carried out to identify the electricity production and consumption within the perimeter of the primary substation and the thermal energy demand of the existing district heating network. The technical features of the energy conversion systems serving the renewable energy community were determined: an organic Rankine cycle biomass-based cogeneration plant, a mini-hydro plant, and a distributed photovoltaic system. Moreover, several different scenarios have been identified, in terms of cogeneration operating mode, photovoltaic penetration, and thermal energy economic value. The results show that, moving from 4.22 MW to 5.22 MW of photovoltaic peak power, the annual renewable electricity production increases by 10.1%. In particular, the simple pay back ranges between 4.90 and 4.98 years and the net present value between EUR 12.4 and 13.3 M for CHP operating at full power mode, considering that thermal energy available from the cogeneration unit is sold at EUR 49.2/MWh. These outcomes demonstrate the economic feasibility of wood-biomass-based renewable energy communities, which may help to enlarge the contribution of renewable technologies other than photovoltaic.
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- 2022
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7. Fever following Covid‐19 vaccination in subjects with Brugada syndrome: Incidence and management
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Francesco Santoro, Pasquale Crea, Pier Luigi Pellegrino, Rosa Cetera, Domenico Gianfrancesco, Mohammad Abumayyaleh, Dattilo Giuseppe, Marta Allegra, Nastasia Mancini, Girolamo D'Arienzo, Andreas Mȕgge, Assem Aweimer, Francesco Bartolomucci, Ibrahim Akin, Ibrahim El‐Battrawy, and Natale Daniele Brunetti
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Adult ,Male ,Antipyretics ,COVID-19 Vaccines ,Fever ,Incidence ,Vaccination ,COVID-19 ,Middle Aged ,Defibrillators, Implantable ,Electrocardiography ,Physiology (medical) ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,Brugada Syndrome - Abstract
Fever is a potential side effect of the Covid-19 vaccination. Patients with Brugada syndrome (BrS) have an increased risk of life-threatening arrhythmias when experiencing fever. Prompt treatment with antipyretic drugs is suggested in these patients.To evaluate the incidence and management of fever within 48 h from Covid-19 vaccination among BrS patients.One hundred sixty-three consecutive patients were enrolled in a prospective registry involving five European hospitals with a dedicated inherited disease ambulatory.The mean age was 50 ± 14 years and 121 (75%) patients were male. Prevalence of Brugada electrocardiogram (ECG) pattern type-1, -2, and -3 was 32%, 44%, and 24%, respectively. Twenty-eight (17%) patients had an implantable cardioverter-defibrillator (ICD). Fever occurred in 32 (19%) BrS patients after 16 ± 10 h from vaccination, with a peak of body temperature of 37.9° ± 0.5°. Patients with fever were younger (39 ± 13 vs. 48 ± 13 years, p = .04). No additional differences in terms of sex and cardiovascular risk factors were found between patients with fever and not. Twenty-seven (84%) out of 32 patients experienced mild fever and five (16%) moderate fever. Pharmacological treatment with antipyretic drugs was required in 18 (56%) out of 32 patients and was associated with the resolution of symptoms. No patient required hospital admission and no arrhythmic episode was recorded in patients with ICD within 48 h after vaccination. No induced type 1 BrS ECG pattern and new ECG features were found among patients with moderate fever.Fever is a common side effect in BrS patients after the Covid-19 vaccination. Careful evaluation of body temperature and prompt treatment with antipyretic drugs may be needed.
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- 2022
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8. Remote Laboratory Testing Demonstration
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Luigi Pellegrino, Carlo Sandroni, Enea Bionda, Daniele Pala, Dimitris T. Lagos, Nikos Hatziargyriou, and Nabil Akroud
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HIL ,CHIL ,integrated laboratories ,real-time communication platform ,power system testing ,Technology - Abstract
The complexity of a smart grid with a high share of renewable energy resources introduces several issues in testing power equipment and controls. In this context, real-time simulation and Hardware in the Loop (HIL) techniques can tackle these problems that are typical for power system testing. However, implementing a convoluted HIL setup in a single infrastructure can be physically impossible or can increase the time required to test a smart grid application in detail. This paper introduces the Joint Test Facility for Smart Energy Networks with Distributed Energy Resources (JaNDER) that allows users to exchange data in real-time between two or more infrastructures. This tool enables the integration of infrastructures, exploiting the synergies between them, and creating a virtual infrastructure that can perform more experiments using a combination of the resources installed in each infrastructure. In particular, JaNDER can extend a HIL setup. In order to validate this new testing concept, a coordinated voltage controller has been tested in a Controller HIL setup where JaNDER was used to interact with an actual On Load Tap Changer (OLTC) controller located in a remote infrastructure. The results show that the latency introduced by JaNDER is not critical; hence, under certain circumstances, it can be used to expand the real-time testing without affecting the stability of the experiment.
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- 2020
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9. Il territorio: palinsesto del progetto. Experience della Scuola di Architettura di Siracusa
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Luigi Pellegrino and Fabio Foti
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- 2023
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10. New methods for the drawing of the Archaeological Forma Urbis: Bohob’s research in Catania
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Laura La Rosa, Luigi Pellegrino, and Matteo Pennisi
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Archaeology ,City ,Architecture - Abstract
Nowadays, in the centre of Catania, the several visible archaeologies seem more irrelevant objects than ancient treasures. This is due to fact they are fenced in scattered holes without any common idea. “Bohob”, the group of architects we belong to, is conducting a research in order to address this burning problem by means of a two-pronged approach. On one hand, by the Drawing of the City, a large plan of Catania including all the archaeological ruins representing their integral role in the building of the city and in forcing the shape of the modern town; on the other hand, by the Minimum Projects, consisting of shrines on a citywide scale in which the ruins are enclosed as well as appearing as gems and not as temporary objects in the urban pattern. The core essence of the research is studying the relationship between the archae-ology and the city via an interdisciplinary method based on the brand-new digital forms of representation; starting from considering the ancient as “active part” in the construction of the town and its little fragments as gems mounted in the urban pattern.
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- 2022
11. Exploitation of Distributed Energy Resources for local services on power distribution network
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Luigi Pellegrino, Riccardo Lazzari, Dario Ronzio, Gaetano Iannarelli, Alessandro Cirocco, and Andrea Ruffini
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- 2022
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12. Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry
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Gabriele Dell'Era, Natale Daniele Brunetti, Enrico Boggio, Pier Luigi Pellegrino, Antonio Dello Russo, Germano Gaggioli, Alessandro Guido, Mauro Biffi, Gerardo Nigro, Ernesto Ammendola, Giuseppe Patti, Mattia Laffi, Matteo Ziacchi, Federico Guerra, Pietro Palmisano, Vittorio Aspromonte, Lorenzo Pimpini, Cardiac Pacing, Michele Accogli, and Francesco Santoro
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Male ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Syncope ,Bifascicular block ,03 medical and health sciences ,Orthostatic vital signs ,0302 clinical medicine ,Heart Rate ,Recurrence ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,In patient ,Prospective Studies ,Registries ,030212 general & internal medicine ,Vasovagal syncope ,Collapse (medical) ,Aged ,biology ,business.industry ,Incidence ,Cardiac Pacing, Artificial ,Syncope (genus) ,Atrial fibrillation ,medicine.disease ,biology.organism_classification ,Italy ,Chronic Disease ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Atrioventricular block ,Follow-Up Studies - Abstract
Background Few studies have examined the causes of syncope/collapse recurrences in patients with a previously implanted pacemaker for bradyarrhythmic syncope. Objective The purpose of this study was to assess the causes of syncope/collapse recurrences after pacemaker implantation for bradyarrhythmic syncope in a large patient population. Methods The SYNCOpal recurrences in patients treated with permanent PACing for bradyarrhythmic syncope (SYNCOPACED) registry was a prospective multicenter observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for bradyarrhythmic syncope. During follow-up, the time to the first syncope/collapse recurrence was recorded. Patients with syncope/collapse recurrences underwent a predefined diagnostic workup aimed at establishing the mechanism of syncope/collapse. Results During a median follow-up of 50 months, 213 patients (15.6%) reported at least 1 syncope/collapse recurrence. The risk of syncope/collapse recurrence was highest in patients who underwent implantation for cardioinhibitory vasovagal syncope (26.4%), followed by unexplained syncope and chronic bifascicular block (21.5%), cardioinhibitory carotid sinus syndrome (17.2%), atrial fibrillation needing pacing (15.5%), atrioventricular block (13.6%), and sinus node disease (12.5%) (P = .017). The most frequent cause of syncope/collapse recurrence was reflex syncope (27.7%), followed by orthostatic hypotension (26.3%), pacemaker or lead malfunction (5.6%), structural cardiac disease (5.2%), and atrial and ventricular tachyarrhythmias (4.7% and 3.8%, respectively). In 26.8% of cases, the mechanism of syncope/collapse remained unexplained. Conclusion In patients receiving a pacemaker for bradyarrhythmic syncope, reflex syncope and orthostatic hypotension are the most frequent mechanisms of syncope/collapse recurrence after implantation. Pacing system malfunction, structural cardiac diseases, and tachyarrhythmias are rare mechanisms. The mechanism remains unexplained in >25% of patients.
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- 2021
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13. Atrial fibrillation ablation: is common practice far from guidelines’ world? The Italian experience from a national survey
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Maria Lucia Narducci, Antonio Di Monaco, Pietro Guida, Gemma Pelargonio, Massimo Grimaldi, Massimo Tritto, Pier Luigi Pellegrino, and Pasquale Vergara
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medicine.medical_specialty ,medicine.medical_treatment ,Population ,Catheter ablation ,030204 cardiovascular system & hematology ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Atrial Fibrillation ,medicine ,Humans ,Vitamin K Inhibitors ,030212 general & internal medicine ,education ,education.field_of_study ,business.industry ,General surgery ,Atrial fibrillation ,Patient data ,medicine.disease ,Ablation ,Treatment Outcome ,Italy ,Pulmonary Veins ,Catheter Ablation ,Oral anticoagulant ,Cardiology and Cardiovascular Medicine ,business - Abstract
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, occurring in 1–2% of the general population. Catheter ablation has become an important treatment modality for patients with symptomatic drug-refractory AF. We report data regarding the AF ablation approaches and modalities in the Italian “real world.” The survey was set-up to collect data on ablation procedure across Italy. All centers performing AF ablation were invited, regardless of the number of annual procedures, to complete a questionnaire regarding their ablation approaches. All centers reported data regarding procedures performed during the year 2017. A total of 3260 procedures were reported from 49 participating hospitals. Most of Italian regions were included in the study. The majority of the centers performed “Always” pulmonary vein isolation (PVI) in paroxysmal and persistent AF catheter ablation, while adjunctive lesions in persistent AF ablation were planned in most of them but not all, and 16% never performed lesions other than PVI. During ablation procedure, vitamin k inhibitors were uninterrupted in 55% of centers, while direct oral anticoagulant in 44% of centers was used uninterruptedly. No relationship was observed between patient data and the number of procedures performed at each center. This survey suggests that the adherence of Italian centers to the most recent European Society of Cardiology guidelines for AF ablation is reasonably high.
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- 2021
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14. Risk of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: role of correlation between symptoms and electrocardiogram findings
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Gabriele Dell'Era, Enrico Boggio, Matteo Ziacchi, Francesco Santoro, Ernesto Ammendola, Giuseppe Patti, Mattia Laffi, Alessandro Guido, Federico Guerra, Vittorio Aspromonte, Michele Accogli, Pietro Palmisano, Germano Gaggioli, Mauro Biffi, Gerardo Nigro, Natale Daniele Brunetti, Lorenzo Pimpini, Pier Luigi Pellegrino, and Antonio Dello Russo
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Bradycardia ,Pacemaker, Artificial ,medicine.medical_specialty ,Population ,Syncope ,law.invention ,Electrocardiography ,Recurrence ,Tilt-Table Test ,law ,Physiology (medical) ,Internal medicine ,Syncope, Vasovagal ,medicine ,Humans ,In patient ,Prospective Studies ,education ,education.field_of_study ,biology ,business.industry ,Hazard ratio ,Cardiac Pacing, Artificial ,Syncope (genus) ,biology.organism_classification ,Treatment Outcome ,Etiology ,Cardiology ,Artificial cardiac pacemaker ,Observational study ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Aims To evaluate the risk of syncopal recurrences after pacemaker implantation in a population of patients with syncope of suspected bradyarrhythmic aetiology. Methods and results Prospective, multicentre, observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for syncope of bradyarrhythmic aetiology (proven or presumed). Before pacemaker implantation, all patients underwent a cardiac work-up in order to establish the bradyarrhythmic aetiology of syncope. According to the results of the diagnostic work-up, patients were divided into three groups: Group A, patients in whom a syncope-electrocardiogram (ECG) correlation was established (n = 329, 24.1%); Group B, those in whom clinically significant bradyarrhythmias were detected without a documented syncope-ECG correlation (n = 877, 64.3%); and Group C, those in whom bradyarrhythmias were not detected and the bradyarrhythmic origin of syncope remained presumptive (n = 158, 11.6%). During a median follow-up of 50 months, 213 patients (15.6%) reported at least one syncopal recurrence. Patients in Groups B and C showed a significantly higher risk of syncopal recurrences than those in Group A [hazard ratios (HRs): 1.60 and 2.66, respectively, P Conclusion In selecting patients with syncope of suspected bradyarrhythmic aetiology for pacemaker implantation, establishing a correlation between syncope and bradyarrhythmias maximizes the efficacy of pacing and reduces the risk of syncopal recurrences.
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- 2020
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15. Concealed structural heart disease discovered at cardiac magnetic resonance in patients with ventricular extrasystoles from ventricular outflow tract and apparently normal hearts
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Matteo Di Biase, Francesca Guastafierro, Pier Luigi Pellegrino, Matteo Gravina, Luca Macarini, Luigi Di Biase, Natale Daniele Brunetti, Grazia Casavecchia, Giuseppe Carpagnano, Francesco Santoro, and Jorge Romero
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medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Heart disease ,Heart Ventricles ,Contrast Media ,Gadolinium ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,Fibrosis ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Ventricular outflow tract ,cardiovascular diseases ,030212 general & internal medicine ,Interventricular septum ,business.industry ,medicine.disease ,Ventricular Premature Complexes ,medicine.anatomical_structure ,Ventricle ,Dysplasia ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Cardiac magnetic resonance - Abstract
Outflow tract (OT) premature ventricular contractions (PVCs) are commonly found in clinical practice; in most cases, PVCs are benign and observed in structurally normal hearts, not requiring any therapeutic intervention. In this study, we therefore sought to evaluate with cardiac magnetic resonance (CMR) patients with PVC and apparently normal heart at echocardiographic examination, in order to identify possible substrates linked with higher prevalence of arrhythmias or structural heart disease. Thirty-three consecutive patients with frequent PVCs originating from the ventricular OT (right and left) were enrolled in the study and assessed by echocardiography and CMR. All patients had normal baseline electrocardiogram. CMR showed structural changes in 5 patients out of 33; in 3 cases, areas of fibrosis limited in one case to the middle basal segments of the interventricular septum and in two patients to the middle basal segments of the inferior-lateral wall were found. In 2 other cases, however, late gadolinium enhancement showed significant anomalies characterized in one patient by extensive areas of subepicardial fibrosis of the left ventricle, suitable with arrhythmogenic left dominant dysplasia; in another patient, a marked trabeculation of left ventricular medium apical segments suitable with non-compaction myocardium was present. CMR may identify cases of structural heart disease in subjects with OT PVCs and apparently normal electrocardiogram and echocardiogram examinations. A preliminary screening with CMR may be considered before any further invasive electrophysiology assessment and therapeutic planning.
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- 2020
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16. Design, realization, and high power test of high gradient, high repetition rate brazing-free S-band photogun
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David Alesini, Antonio Battisti, Marco Bellaveglia, Fabio Cardelli, Antonio Falone, Alessandro Gallo, Valerio Lollo, Dennis Thomas Palmer, Luigi Pellegrino, Luca Piersanti, Stefano Pioli, Alessandro Variola, Valerio Pettinacci, and Luigi Palumbo
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
rf photoguns find several types of applications as high brightness electron sources for free-electron lasers, energy recovery linacs, Compton and Thomson sources, and high-energy linear colliders. The high peak current and low transverse emittance of the generated beam are obtained with the combination of a high peak electric field (>100 MV/m) at the cathode surface, a proper choice of the solenoid field around, or immediately after, the gun, and special fabrication and treatments of the cathode itself. On the other hand, to increase the average electron current, a high repetition rate (>100 Hz) and/or a multibunch rf gun have to be developed. These types of devices are, in general, fabricated by brazing processes of copper machined parts. The brazing processes require a large vacuum furnace, are very expensive, and pose a not negligible risk of failure. A new fabrication technique for this type of structure has been recently developed and implemented at the Laboratories of Frascati of the National Institute of Nuclear Physics (INFN-LNF, Italy) and already applied to an rf gun now operating at a relatively low cathode peak field and low repetition rate [D. Alesini et al., Phys. Rev. Accel. Beams 18, 092001 (2015)]. It is based on the use of special rf-vacuum gaskets that allow a brazing-free realization process. The S-band gun of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System, under construction in Magurele (Bucharest, Romania), has been realized with this new technique and represents a further and fundamental step toward the consolidation of this technology for high gradient particle accelerator fabrication. It operates at 100 Hz with a 120 MV/m cathode peak field and 1.5-μs-long rf pulses to house the 32 bunches necessary to reach the target gamma flux. High gradient tests, performed at full power and a full repetition rate, have shown the extremely good performances of the structure in terms of the breakdown rate and conditioning time and definitively demonstrated the reliability and suitability of such fabrication process for high gradient structure realization. In this paper, we report and discuss the electromagnetic and thermomechanical design, the realization process, and all the experimental results at low and high power at a full repetition rate.
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- 2018
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17. Management of older patients with unexplained, recurrent, traumatic syncope and bifascicular block: Implantable loop recorder versus empiric pacemaker implantation-Results of a propensity-matched analysis
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Pietro Palmisano, Federico Guerra, Vittorio Aspromonte, Gabriele Dell’Era, Pier Luigi Pellegrino, Mattia Laffi, Carlo Uran, Silvana De Bonis, Michele Accogli, Antonio Dello Russo, Giuseppe Patti, Francesco Santoro, Antonella Torriglia, Gerardo Nigro, Antonio Bisignani, Giovanni Coluccia, Giulia Stronati, Vincenzo Russo, Ernesto Ammendola, Palmisano, Pietro, Guerra, Federico, Aspromonte, Vittorio, Dell'Era, Gabriele, Pellegrino, Pier Luigi, Laffi, Mattia, Uran, Carlo, De Bonis, Silvana, Accogli, Michele, Dello Russo, Antonio, Patti, Giuseppe, Santoro, Francesco, Torriglia, Antonella, Nigro, Gerardo, Bisignani, Antonio, Coluccia, Giovanni, Stronati, Giulia, Russo, Vincenzo, and Ammendola, Ernesto
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Aged, 80 and over ,Male ,Pacemaker, Artificial ,Unexplained syncope ,Bundle-Branch Block ,Empiric pacemaker implantation ,Bradyarrhythmia ,Syncope ,Bifascicular block ,Pacemaker ,Traumatic syncope ,Implantable loop recorder ,Insertable cardiac monitor ,Physiology (medical) ,Bradycardia ,Electrocardiography, Ambulatory ,Humans ,Female ,Prospective Studies ,Cardiology and Cardiovascular Medicine ,Aged - Abstract
In patients with unexplained syncope and bifascicular block (BFB), syncope may be caused by intermittent atrioventricular (AV) block. When a correlation between syncope and bradyarrhythmia is not documented in these patients, 2 alternative management strategies can be adopted: (1) empiric pacemaker (PM) implantation or (2) long-term continuous electrocardiographic monitoring by implantable loop recorder (ILR).The purpose of this study was to compare the risk of syncope recurrence associated with empiric PM implantation or ILR monitoring.A prospective, multicenter, observational study enrolled consecutive patients with unexplained, recurrent, traumatic syncope and BFB who underwent ILR monitoring or empiric PM implantation. The risk and causes of syncope recurrence were assessed and compared between the 2 groups. Individual 1:1 propensity matching of baseline characteristics was performed.A total of 309 consecutive patients (age 77.2 ± 12.2 years; 60.8% male) were enrolled. Propensity matching yielded 89 matched pairs. After median follow-up of 33 months, empiric PM implantation was associated with a significantly lower risk of syncope recurrence than ILR monitoring (19.1 vs 46.1%; P.001). A total of 35 patients (39.3%) who underwent ILR monitoring developed bradyarrhythmias (68.6% paroxysmal AV block) requiring PM implantation during follow-up. Excluding bradyarrhythmic syncope, the most frequent causes of syncope recurrence in both study groups were reflex syncope and orthostatic hypotension.In patients with unexplained, recurrent, traumatic syncope and BFB, empiric PM implantation significantly reduced the risk of syncope recurrence in comparison with ILR monitoring. A high rate of patients who underwent ILR monitoring developed bradyarrhythmias requiring PM implantation.
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- 2022
18. Catania, ciudad de lava sobre el mar. La casa como construcción del paisaje
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Luigi Pellegrino
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bosque ,sea ,città ,ciudad ,Etna, Catania, lava, mar, ciudad, bosque, casa, paisaje ,landscape ,house ,lava ,bosco ,paesaggio ,settlement ,mar ,Etna, Catania, lava, sea, settlement, wood, house, landscape ,mare ,casa ,paisaje ,Etna ,Catania ,Etna, Catania, lava, mare, città, bosco, casa, paesaggio ,wood - Abstract
Por medio de algunos mapas y vistas se reconoce la particularísima relación entre Catania y el Etna: la ciudad está asentada sobre el volcán que llega hasta el mar. La Veduta dalla parte meridionale grabada por Sebastiano Ittar -casi un frente más que perspectiva- permite distinguir cuatro paisajes sucesivos.
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- 2022
19. Battery lifetime of electric vehicles by novel rainflow-counting algorithm with temperature and C-rate dynamics: Effects of fast charging, user habits, vehicle-to-grid and climate zones
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Davide Fioriti, Claudio Scarpelli, Luigi Pellegrino, Giovanni Lutzemberger, Enrica Micolano, and Sara Salamone
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Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering - Published
- 2023
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20. A Novel DLG1 Variant in a Family with Brugada Syndrome: Clinical Characteristics and In Silico Analysis
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Maria d’Apolito, Francesco Santoro, Rosa Santacroce, Giorgia Cordisco, Ilaria Ragnatela, Girolamo D’Arienzo, Pier Luigi Pellegrino, Natale Daniele Brunetti, and Maurizio Margaglione
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Genetics ,Brugada syndrome ,DLG1 ,gene ,Genetics (clinical) - Abstract
Background: Brugada syndrome (BrS) is an inherited primary channelopathy syndrome associated to sudden cardiac death. Overall, variants have been identified in eighteen genes encoding for ion channel subunits and seven genes for regulatory proteins. Recently, a missense variant in DLG1 has been found within a BrS phenotype-positive patient. DLG1 encodes for synapse associated protein 97 (SAP97), a protein characterized by the presence of multiple domains for protein–protein interactions including PDZ domains. In cardiomyocytes, SAP97 interacts with Nav1.5, a PDZ binding motif of SCN5A and others potassium channel subunits. Aim of the Study: To characterize the phenotype of an Italian family with BrS syndrome carrying a DLG1 variant. Methods: Clinical and genetic investigations were performed. Genetic testing was performed with whole-exome sequencing (WES) using the Illumina platform. According to the standard protocol, a variant found by WES was confirmed in all members of the family by bi-directional capillary Sanger resequencing. The effect of the variant was investigated by using in silico prediction of pathogenicity. Results: The index case was a 74-year-old man with spontaneous type 1 BrS ECG pattern that experienced syncope and underwent ICD implantation. WES of the index case, performed assuming a dominant mode of inheritance, identified a heterozygous variant, c.1556G>A (p.R519H), in the exon 15 of the DLG1 gene. In the pedigree investigation, 6 out of 12 family members had the variant. Carriers of the gene variant all had BrS ECG type 1 drug induced and showed heterogeneous cardiac phenotypes with two patients experiencing syncope during exercise and fever, respectively. The amino acid residue #519 lies near a PDZ domain and in silico analysis suggested a causal role for the variant. Modelling of the resulting protein structure predicted that the variant disrupts an H-bond and a likelihood of being pathogenic. As a consequence, it is likely that a conformational change affects protein functionality and the modulating role on ion channels. Conclusions: A DLG1 gene variant identified was associated with BrS. The variant could modify the formation of multichannel protein complexes, affecting ion channels to specific compartments in cardiomyocytes.
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- 2023
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21. Embryonic twin cities
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Dario Musolino and Luigi Pellegrino
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Geography ,Economic geography ,Twin cities - Published
- 2021
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22. Optimal Design of Energy Communities in the Italian Regulatory Framework
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Guido Coletta and Luigi Pellegrino
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- 2021
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23. Command and control system for the STAR X-ray source
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Luca Serafini, Riccardo Barberi, Matteo Nobili, Gaetano Catuscelli, Daniela Cucè, Gianluca Borgese, Luigi Pellegrino, Riccardo Lisi, Ezio Puppin, Andrea Solano, Raffaele Giuseppe Agostino, Giuseppe Razzano, Alessandro Schisano, Joseph Beltrano, Alberto Bacci, Dario Leone, Giovanni Di Maio, and Andrea Ghigo
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Computer science ,01 natural sciences ,Collimated light ,Linear particle accelerator ,Command and control system ,EPICS ,Particle accelerator ,Thomson back-scattering ,X-ray source ,Civil and Structural Engineering ,Nuclear Energy and Engineering ,Materials Science (all) ,Mechanical Engineering ,010305 fluids & plasmas ,law.invention ,Software ,law ,0103 physical sciences ,General Materials Science ,010306 general physics ,business.industry ,Electrical engineering ,Process (computing) ,Laser ,Control system ,Scalability ,business - Abstract
The Southern Europe Thomson Backscattering Source for Applied Research (STAR) is a compact hard Xray source designed by INFN, for advanced applied materials-science research. It is funded by Progetto MaTeRiA, a partnership between the University of Calabria and CNISM (Consorzio Nazionale Interuniversitario per le Scienze fisiche della Materia). The machine has been installed at the University of Calabria (UNICAL); the X-ray beam is produced using the Thomson Back-scattering process, where relativistic electron bunches, accelerated by a 60 MeV Linear Accelerator (LINAC), interact with very short photon pulses, produced a by a 30 mJ@5 ps IR (Infrared) Pulsed Laser. The EPICS-based command/control system (ComConS) of the STAR machine has been designed and currently is under commissioning, using state of the art technologies and making extensive use of COTS hardware and software, assuring full control and supervision of the whole machine and all relevant subsystems: Beam diagnostics, Magnets power supplies, RF devices, Laser systems, Vacuum subsystem, Machine Protection System, Personnel Protection System and Trigger and Timing system. A growth potential has been considered since design phase, in order to take into account any future expansions of the control system during the lifecycle of the facility, without impact on the performance. Scalability of systems is also a crucial issue. The current design allows to generate tunable collimated monochromatic X-rays in the range between 10 and 200 keV. Possible future evolution will be to obtain a machine to generate higher energy X-ray beams, towards the MeV. The control system from both SW and HW points of view has to accommodate this need, as well as operating the machine for a long lifecycle.
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- 2019
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24. An online state of health estimation method for lithium-ion batteries based on time partitioning and data-driven model identification
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Marco Mussi, Luigi Pellegrino, Marcello Restelli, and Francesco Trovò
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Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering - Published
- 2022
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25. The impact of Energy Communities on the Italian distribution systems
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Guido Coletta and Luigi Pellegrino
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Distribution system ,Order (exchange) ,business.industry ,Energy (esotericism) ,Key (cryptography) ,Production (economics) ,media_common.cataloged_instance ,Electricity ,Environmental economics ,European union ,business ,Renewable energy ,media_common - Abstract
After a decade since the 20-20-20 Climate-Energy package, there are still many challenges to be faced in order to achieve decarbonisation of the electric energy sector. The European Union has set very challenging objectives for 2030 by providing for an even more massive diffusion of the distributed renewable generation units. In order to do so, the active participation of citizens in the mechanisms of production and sale of electricity has been identified as key factor for achieving these objectives. For this reason, RED-II and IEM directives introduced new entities, which allow citizens to become active players in the electricity system by producing, storing and selling self-produced renewable electricity. This research paper aims at analysing the Renewable Energy Community scheme resulting from the Italian implementation of EU regulations and how it will impact on the electric distribution systems. The study has been performed considering national statistics and shows that Renewable Energy Community can contribute to achieve 63% of the 2030 target of the renewable energy sources installation.
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- 2021
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26. Design of high gradient, high repetition rate damped C-band rf structures
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David Alesini, Marco Bellaveglia, Simone Bini, Alessandro Gallo, Valerio Lollo, Luigi Pellegrino, Luca Piersanti, Fabio Cardelli, Mauro Migliorati, Andrea Mostacci, Luigi Palumbo, Simone Tocci, Luca Ficcadenti, and Valerio Pettinacci
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The gamma beam system of the European Extreme Light Infrastructure–Nuclear Physics project foresees the use of a multibunch train colliding with a high intensity recirculated laser pulse. The linac energy booster is composed of 12 traveling wave C-band structures, 1.8 m long with a field phase advance per cell of 2π/3 and a repetition rate of 100 Hz. Because of the multibunch operation, the structures have been designed with a dipole higher order mode (HOM) damping system to avoid beam breakup (BBU). They are quasiconstant gradient structures with symmetric input couplers and a very effective damping of the HOMs in each cell based on silicon carbide (SiC) rf absorbers coupled to each cell through waveguides. An optimization of the electromagnetic and mechanical design has been done to simplify the fabrication and to reduce the cost of the structures. In the paper, after a review of the beam dynamics issues related to the BBU effects, we discuss the electromagnetic and thermomechanic design criteria of the structures. We also illustrate the criteria to compensate the beam loading and the rf measurements that show the effectiveness of the HOM damping.
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- 2017
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27. EuPRAXIA conceptual design report
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Ke Wang, A. Y. Molodozhentsev, L. Boulton, Barbara Marchetti, Maria Weikum, Giuseppe Dattoli, Ulrich Schramm, P. Delinikolas, Victor Malka, T. L. Audet, Anna Giribono, Cristina Vaccarezza, Erik Bründermann, Marco Bellaveglia, Fernando Brandi, Vladimir Shpakov, F. Massimo, Dimitris N. Papadopoulos, D. Ullmann, Manuel Kirchen, Christophe Simon-Boisson, Axel Bernhard, Luca Piersanti, Marco Galimberti, Masaki Kando, Federico Nguyen, Suming Weng, Dario Giove, Thomas M. Spinka, Barbara Patrizi, A. Ghigo, R. Pattathil, M. A. Pocsai, Arie Irman, A. Chancé, Y. Zhao, Hao Zhang, Zulfikar Najmudin, Vladimir Litvinenko, Fabrice Marteau, G. Kirwan, U. Rotundo, Florian Grüner, L. O. Silva, F. Falcoz, Joana Luis Martins, D. Alesini, D. Khikhlukha, Francesco Iungo, Z. Mazzotta, Angelo Biagioni, A. F. Habib, Wim Leemans, S. Jaster-Merz, Alessandro Vannozzi, Leonida A. Gizzi, Fabien Briquez, S. Bartocci, Petra Koester, Tamina Akhter, Phu Anh Phi Nghiem, G. C. Bussolino, Jorge Vieira, Adolfo Esposito, D. Di Giovenale, Jens Osterhoff, Sergio Cantarella, Kristjan Poder, Bernhard Holzer, Nicolas Delerue, Brigitte Cros, Fabio Villa, Igor Andriyash, Alessandro Stecchi, Paul Crump, Sally Wiggins, Constantin Haefner, A. Del Dotto, Oscar Jakobsson, Alessandro Gallo, Emily Sistrunk, G. Di Pirro, Olena Kononenko, Yang Li, P. Campana, A. Martinez de la Ossa, Anke-Susanne Müller, Christoph Lechner, Brendan A. Reagan, Stuart Mangles, Andrew Sutherland, D. Kocon, E. N. Svystun, Simon M. Hooker, Ruggero Ricci, Javier Resta-López, C. D. Murphy, R. Walczak, Dino A. Jaroszynski, M. Yabashi, Chan Joshi, P. Santangelo, Maria Pia Anania, Konstantin Kruchinin, C. Simon, M. Hübner, C. A. Lindstrøm, Markus Büscher, Ulrich Dorda, J. Wolfenden, Alvin C. Erlandson, G. Korn, Sergey Mironov, Alessandro Rossi, Carl Schroeder, Zheng-Ming Sheng, Olle Lundh, T. Silva, Lucas Schaper, A. Ferran Pousa, M. Del Franco, Audrey Beluze, M. H. Bussmann, Alberto Marocchino, Gilles Maynard, Min Chen, Andrea Mostacci, Alexander Knetsch, Renato Fedele, M. Rossetti Conti, Amin Ghaith, G. Costa, R. Brinkmann, Gaetano Fiore, Claes-Göran Wahlström, J. Fils, Luca Serafini, Fabrizio Bisesto, J. Cowley, X. Li, Andreas Lehrach, Augusto Marcelli, Vittoria Petrillo, M. Ibison, Antonio Falone, A. Beck, Bruno Buonomo, D. Oumbarek Espinos, Daria Pugacheva, Stefan Karsch, A. Beaton, A. Nutter, Carsten Welsch, F. Mathieu, Christophe Szwaj, R. Fiorito, Paul Scherkl, C. Le Blanc, Arie Zigler, J. Scifo, Malte C. Kaluza, Craig W. Siders, Angelo Stella, Mathieu Valléau, Ujjwal Sinha, M. J. V. Streeter, A. Welsch, Efim A. Khazanov, Eléonore Roussel, Gianluca Sarri, Lucia Sabbatini, Silvia Morante, T. Heinemann, A. Aschikhin, G. Di Raddo, L. Pribyl, S. Romeo, Alberto Bacci, N. E. Andreev, Matteo Vannini, A. Bonatto, Francesco Filippi, Klaus Ertel, Riccardo Pompili, Ricardo Fonseca, Olivier Marcouillé, E. Di Pasquale, Jason Cole, M. Artioli, R. D'Arcy, Giovanni Franzini, Marco Diomede, Andreas Maier, I. Kostyukov, A. Specka, Serge Bielawski, Wei Lu, F. Cioeta, A. Mosnier, Grace Manahan, S. Vescovi, Alessandro Cianchi, P. Niknejadi, Francesco Stellato, Luigi Pellegrino, Oliver Karger, A. Helm, Bernhard Hidding, Paolo Tomassini, J. A. Clarke, A. Petralia, Davide Terzani, Enrica Chiadroni, Ralph Assmann, Alexandra Alexandrova, Paul Mason, R. Rossmanith, Jun Zhu, Thomas C. Galvin, R. Torres, Agustin Lifschitz, M. E. Couprie, Massimo Ferrario, F. Brottier, S. De Nicola, Kevin Cassou, Tomonao Hosokai, Andy J. Bayramian, J. L. Paillard, Gabriele Tauscher, P. A. Walker, Geetanjali Sharma, P. Lee, Guido Toci, Farzad Jafarinia, Simona Incremona, Imre Ferenc Barna, Charles Kitegi, D. R. Symes, M. Croia, Vladyslav Libov, J. M. Dias, Guoxing Xia, L. Labate, Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Brundermann, E., Buscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chance, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D'Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. M., Di Giovenale, D., Diomede, M., Di Pasquale, E., Di Pirro, G., Di Raddo, G., Dorda, U., Erlandson, A. C., Ertel, K., Esposito, A., Falcoz, F., Falone, A., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fils, J., Fiore, G., Fiorito, R., Fonseca, R. A., Franzini, G., Galimberti, M., Gallo, A., Galvin, T. C., Ghaith, A., Ghigo, A., Giove, D., Giribono, A., Gizzi, L. A., Gruner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Helm, A., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Hubner, M., Ibison, M., Incremona, S., Irman, A., Iungo, F., Jafarinia, F. J., Jakobsson, O., Jaroszynski, D. A., Jaster-Merz, S., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Kirchen, M., Kirwan, G., Kitegi, C., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Le Blanc, C., Lechner, C., Lee, P., Leemans, W., Lehrach, A., Li, X., Li, Y., Libov, V., Lifschitz, A., Lindstrom, C. A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marcelli, A., Marchetti, B., Marcouille, O., Marocchino, A., Marteau, F., Martinez de la Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Mironov, S., Molodozhentsev, A. Y., Morante, S., Mosnier, A., Mostacci, A., Muller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Nutter, A., Osterhoff, J., Oumbarek Espinos, D., Paillard, J. -L., Papadopoulos, D. N., Patrizi, B., Pattathil, R., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Reagan, B. A., Resta-Lopez, J., Ricci, R., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Rotundo, U., Roussel, E., Sabbatini, L., Santangelo, P., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sharma, G., Sheng, Z. M., Shpakov, V., Siders, C. W., Silva, L. O., Silva, T., Simon, C., Simon-Boisson, C., Sinha, U., Sistrunk, E., Specka, A., Spinka, T. M., Stecchi, A., Stella, A., Stellato, F., Streeter, M. J. V., Sutherland, A., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Valleau, M., Vannini, M., Vannozzi, A., Vescovi, S., Vieira, J. M., Villa, F., Wahlstrom, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, A., Welsch, C. P., Weng, S. M., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhang, H., Zhao, Y., Zhu, J., Zigler, A., Deutsches Elektronen-Synchrotron [Hamburg] (DESY), Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (INFN, Sezione di Napoli), Istituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali di Frascati (LNF), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Engineering & Physical Science Research Council (EPSRC), Science and Technology Facilities Council (STFC), and EuPRAXIA
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Technology ,electron: energy ,AMPLIFIED SPONTANEOUS-EMISSION ,wake field [plasma] ,General Physics and Astronomy ,costs ,plasma: wake field ,free electron laser ,GeV ,01 natural sciences ,7. Clean energy ,wake field [acceleration] ,010305 fluids & plasmas ,law.invention ,Laser technology ,acceleration: wake field ,Conceptual design ,FREE-ELECTRON LASER ,AT-SPARC-LAB ,law ,IN-CELL CODE ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,PLASMA-WAKEFIELD ACCELERATION ,General Materials Science ,LATERAL SHEARING INTERFEROMETRY ,media_common ,Applied Physics ,Settore FIS/01 ,02 Physical Sciences ,T1 ,light source ,Physics ,Settore FIS/07 ,accelerator: plasma ,Schedule (project management) ,Physical Sciences ,Systems engineering ,positron ,Plasma acceleration ,X rays ,compact accelerators ,performance ,WAKE-FIELD ACCELERATION ,X-RAY SOURCE ,Project implementation ,Fluids & Plasmas ,Physics, Multidisciplinary ,accelerator [electron] ,Physics and Astronomy(all) ,HIGH PEAK POWER ,electron: accelerator ,horizon ,medicine: imaging ,X-ray ,accelerators ,Materials Science(all) ,0103 physical sciences ,media_common.cataloged_instance ,ddc:530 ,European union ,Physical and Theoretical Chemistry ,010306 general physics ,energy [electron] ,01 Mathematical Sciences ,plasma: acceleration ,acceleration [plasma] ,Electron energy ,Science & Technology ,imaging [medicine] ,plasma [accelerator] ,Particle accelerator ,plasmas ,Accelerators and Storage Rings ,laser ,Automatic Keywords ,gamma ray ,linear collider ,ddc:600 ,CHIRPED-PULSE AMPLIFICATION - Abstract
European physical journal special topics 229(24), 3675 - 4284 (2020). doi:10.1140/epjst/e2020-000127-8, This report presents the conceptual design of a new European research infrastructure EuPRAXIA. The concept has been established over the last four years in a unique collaboration of 41 laboratories within a Horizon 2020 design study funded by the European Union. EuPRAXIA is the first European project that develops a dedicated particle accelerator research infrastructure based on novel plasma acceleration concepts and laser technology. It focuses on the development of electron accelerators and underlying technologies, their user communities, and the exploitation of existing accelerator infrastructures in Europe. EuPRAXIA has involved, amongst others, the international laser community and industry to build links and bridges with accelerator science — through realising synergies, identifying disruptive ideas, innovating, and fostering knowledge exchange. The Eu-PRAXIA project aims at the construction of an innovative electron accelerator using laser- and electron-beam-driven plasma wakefield acceleration that offers a significant reduction in size and possible savings in cost over current state-of-the-art radiofrequency-based accelerators. The foreseen electron energy range of one to five gigaelectronvolts (GeV) and its performance goals will enable versatile applications in various domains, e.g. as a compact free-electron laser (FEL), compact sources for medical imaging and positron generation, table-top test beams for particle detectors, as well as deeply penetrating X-ray and gamma-ray sources for material testing. EuPRAXIA is designed to be the required stepping stone to possible future plasma-based facilities, such as linear colliders at the high-energy physics (HEP) energy frontier. Consistent with a high-confidence approach, the project includes measures to retire risk by establishing scaled technology demonstrators. This report includes preliminary models for project implementation, cost and schedule that would allow operation of the full Eu-PRAXIA facility within 8—10 years., Published by Springer, Heidelberg
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- 2020
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28. Research Infrastructures integration to foster Smart Grid testing
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Ricardo Lazzari, Maurizio Verga, Luigi Pellegrino, and Carlo Sandroni
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Scope (project management) ,business.industry ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,System testing ,02 engineering and technology ,Energy transition ,Electrical grid ,Smart grid ,Distributed generation ,Component (UML) ,0202 electrical engineering, electronic engineering, information engineering ,Systems engineering ,Real-time data ,business - Abstract
The energy transition is changing the electrical power system. The increasing number of distributed energy resources in the distribution system and the digitalisation of most of the sensors and actuators are bringing the electrical grid to became a Smart Grid. Component and system testing for Smart Grid topics can introduce many challenges. ERIGrid Project tried to Figure out some of the upcoming issues investigating the possibility to expand Smart Grids laboratories potentialities and capabilities by means of research institutes cooperation and Research Infrastructures integration. Different tools for laboratory integration have been developed in the project. Among them a new methodology, called Holistic Test Description, has been developed with the goal to help researchers to clearly identify the test scope and the best test procedure to be adopted. Moreover a new communication tool, called JaNDER, has been developed by Ricerca sul Sistema Energetico (RSE) which is also member of the consortium of ERIGrid Project. This tool allows real time data communication between Research Infrastructures in an easy and effective way enabling a virtual connection between laboratories. These tools have been successfully tested and proved in the Distributed Energy Resources Test Facility (DER-TF) of RSE both by RSE researchers and also external users demonstrating the possibility to largely extend Smart Grid laboratories experimental potentialities. This paper shows some of the developed tools and presents some tests performed in RSE DER-TF that demonstrate how laboratories integration can reduce test set-up timing, optimise laboratory usage and improve the quality of experimental testing activities.
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- 2020
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29. An Investigation of V2G Profitability with Robust Optimization and Bidding Price Heuristics
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Antonio Gatti, Luigi Pellegrino, Riccardo Vignali, and S. Canevese
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Stochastic control ,Mathematical optimization ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,Robust optimization ,02 engineering and technology ,Bidding ,Optimal control ,Charging station ,Electric power system ,0202 electrical engineering, electronic engineering, information engineering ,Profitability index ,Heuristics - Abstract
Over the last years the number of Electric Vehicles (EVs) has been growing more than expected, and a massive growth is foreseen for the next decade. An increase of consumption due to EV charging is then expected, with possible drawbacks, like undesired peaks, for distribution and transmission system operators. However, EVs are indeed storage systems, and, therefore, they can be employed to provide flexibility to the power system: this is known as the Vehicle-to-Grid (V2G) concept. This paper aims at investigating a V2G control strategy for the EV charging stations in a public or private parking lot, in order to provide flexibility services by participating in the Ancillary Service Market (ASM).The energy to be exchanged on the ASM, and also on the Day-Ahead Market (DAM), is obtained by solving an optimal control problem that maximizes the EV charging station operator’s daily profit while ensuring the desired minimum State of Charge (SoC) of each EV at the end of the recharge. The cycling aging of EV batteries is considered in particular via the price of the discharged energy. The problem is formulated in a robust way to take into account uncertainties on ASM bid acceptance. The bidding prices on the ASM act as problem inputs, and therefore have to be suitably chosen. The different heuristic strategies proposed here for this choice are based on an analysis performed on one-year data of the Italian ASM. The mixed heuristic and robust approach yields different economic results, depending on the adopted bidding price strategy. The results provide interesting input for further developments of business cases for V2G applications.
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- 2020
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30. Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study
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Vittorio Aspromonte, Antonio Dello Russo, Michele Accogli, Federico Guerra, Miriam Gravellone, Gabriele Dell'Era, Natale Daniele Brunetti, Pasquale Paolisso, Giulia Stronati, Angelo Carbone, Alessandro Guido, Matteo Ziacchi, Pietro Palmisano, Roberto Floris, Giampiero Maglia, Roberto Antonicelli, Ernesto Ammendola, Gerardo Nigro, Lorenzo Pimpini, Pier Luigi Pellegrino, Giuseppe Del Giorno, Francesco Santoro, and Michele Cannone
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Comorbidity ,Sacubitril ,Ventricular Function, Left ,Sudden cardiac death ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Prospective Studies ,education ,Aged ,Pharmacology ,Heart Failure ,education.field_of_study ,Ejection fraction ,business.industry ,Aminobutyrates ,Biphenyl Compounds ,General Medicine ,Middle Aged ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Drug Combinations ,Valsartan ,Heart failure ,Cardiology ,Female ,business ,Sacubitril, Valsartan ,medicine.drug - Abstract
Sacubitril/valsartan has been associated with a positive reverse left ventricular remodelling in patients with heart failure with reduced ejection fraction (HFrEF). These patients may also benefit from an ICD implant. We aimed to assess EF improvement after 6 months of treatment with sacubitril/valsartan, evaluating when ICD as primary prevention was no longer indicated.Multicentre, observational, prospective study enrolling all consecutive patients with HFrEF and EF ≤ 35% with an ICD as primary prevention and starting treatment with sacubitril/valsartan (NCT03935087). Resynchronization therapy and patients experiencing appropriate ICD therapies before sacubitril/valsartan were excluded.Two-hundred-and-thirty patients were enrolled (73.9% males, mean age 64.3 ± 12.1 years) After 6 months of treatment, a reduction in left ventricular end-diastolic and end-systolic volumes was noted and LVEF increased from 28.3 ± 5.6% to 32.2 ± 6.5% (p 0.001). At 6 months, a non-ischemic aetiology of cardiomyopathy and a final dose of sacubitril/valsartan 24/26 mg twice daily were associated with a higher probability of an absolute increase of 5% in LVEF. A total of 5.3% of primary prevention patients still had an arrhythmic event in the first 6 months after treatment with sacubitril/valsartan started.Sacubitril/valsartan improves systolic function in HFrEF, mainly due to reverse left ventricular remodelling. Improvement in EF after 6 months of treatment could help prevent ICD implantation in nearly one out of four patients, with important clinical and economic implications. However, the risk of sudden cardiac death in this recovered HFrEF population has not been thoroughly studied, and the present data should be interpreted only as hypothesis-generating.
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- 2020
31. Laboratory coupling approach
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Van Hoa Nguyen, Quoc Tuan Tran, R. Bhandia, Vetrivel Subramaniam Rajkumar, J. Jimeno, Dimitris T. Lagos, Efren Guillo-Sansano, Mazheruddin H. Syed, Nabil Akroud, Marios Maniatopoulos, Kai Heussen, Julia Merino, Enea Bionda, Daniele Pala, Luigi Pellegrino, Panos Kotsampopoulos, Oliver Gehrke, Strasser, Thomas I., de Jong, Erik C. W., and Sosnina, Maria
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Coupling ,Electric power system ,Smart grid ,Computer science ,TK ,Electronic engineering ,Joint (building) ,System configuration ,Reference implementation - Abstract
This chapter deals with the coupling of smart grid laboratories for joint experiments. Therefore, various possibilities are outlined and a reference implementation is introduced. Finally, the vision of a distributed, virtual research infrastructure is presented.
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- 2020
32. Optimal sizing of residential battery systems with multi-year dynamics and a novel rainflow-based model of storage degradation: An extensive Italian case study
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Luigi Pellegrino, Davide Poli, Giovanni Lutzemberger, Enrica Micolano, and Davide Fioriti
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Battery (electricity) ,Long-term optimization ,Computer science ,Photovoltaic system ,Domestic microgrid ,Heuristic optimization ,Hybrid energy home systems design ,Lithium Battery Energy Storage System (BESS) ,State-of-Health (SoH) ,Scheduling (production processes) ,Energy Engineering and Power Technology ,Investment (macroeconomics) ,Net present value ,Sizing ,Reliability engineering ,Profitability index ,Electrical and Electronic Engineering ,Load shifting - Abstract
Residential battery storage to perform load shifting and demand side management has become of utmost importance to improve hosting capacity, increase renewable energy penetration and meet environmental targets, especially with energy community policies. As the lifetime of electrochemical batteries depends upon their scheduling and environmental conditions, the multi-year effects of operational strategies can affect the economics of the investment. However, rarely complete long-term simulations of the operation of storage systems are performed to assess the battery profitability including the operational effects of aging, and limited studies account for a large statistics of consumers. In this study, we propose a multi-year sizing methodology for residential applications, where the complete lifetime of batteries is simulated at 15-min time resolution till complete degradation using an improved non-linear non-convex degradation model; the photovoltaic plant aging is also considered. An extensive analysis on the economics and commercial size best suited for 399 real load profiles in Italy is proposed. Results suggest that the break-even price of the storage is about 400 €/kWh, which is lower than the average commercial price, and that, as reviewed, current market components may be unfit for consumers with low energy demand. Net Present Value (NPV) and Discounted PayBack Time (DPBT) can reach 500-1500 € and 8-11 years.
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- 2022
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33. A voltage dynamic-based state of charge estimation method for batteries storage systems
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Marcello Restelli, Francesco Trovò, Luigi Pellegrino, and Marco Mussi
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Battery (electricity) ,Lithium-ion batteries ,Offset (computer science) ,Renewable Energy, Sustainability and the Environment ,Computer science ,Energy Engineering and Power Technology ,Internal resistance ,Energy storage ,Power (physics) ,State of charge ,State of charge estimation ,Electronic engineering ,Online model ,Electrical and Electronic Engineering ,Energy (signal processing) ,Voltage - Abstract
In recent years, the use of Lithium-ion batteries in smart power systems and hybrid/electric vehicles has become increasingly popular since they provide a flexible and cost-effective way to store and deliver power. Their full integration into more complex systems requires an accurate estimate of the energy a battery is currently storing, a.k.a. State of Charge (SoC). However, the standard techniques present in the literature provide an accurate estimation of the SoC only having a priori knowledge about the battery. Moreover, their accuracy degrades if the battery working conditions (e.g., external temperature) are variable over time, or battery measurements necessary for the SoC estimation are affected by offset or gain biases. To overcome these limitations, this paper proposes a novel data-driven optimization based methodology for battery SoC estimation, namely VDB-SE. The proposed methodology provides accurate SoC estimations without knowing battery model parameters, such as capacity and internal resistance, whose characterization would require complex and long laboratory tests. Experimental verification and comparisons demonstrate that VDB-SE performance are comparable to the state-of-the-art algorithms over a wide range of working conditions. Indeed, the difference in terms of performance is smaller than 0.2%. Moreover, experimental results showed that on a real energy storage system the proposed method provides a SoC estimation with an error of less than 2.1%.
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- 2021
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34. Dynamic changes of QTc interval and prognostic significance in takotsubo (stress) cardiomyopathy
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Armando Ferraretti, Francesca Guastafierro, Luigi Di Martino, Jorge Romero, Natale Daniele Brunetti, Pier Luigi Pellegrino, Francesco Santoro, Riccardo Ieva, Matteo Di Biase, Nicola Tarantino, and Luigi Di Biase
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ST depression ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Proportional hazards model ,ST elevation ,Hazard ratio ,General Medicine ,030204 cardiovascular system & hematology ,QT interval ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,030212 general & internal medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Prospective cohort study ,Electrocardiography - Abstract
Background Prolonged QT corrected (QTc) intervals are associated with adverse cardiovascular outcomes both in healthy and high-risk populations. Our objective was to evaluate the QTc intervals during a takotsubo cardiomyopathy (TTC) episodes and their potential prognostic role. Hypothesis Dynamic changes of QTc interval during hospitalization for TTC could be associated with outcome at follow-up. Methods Fifty-two consecutive patients hospitalized for TTC were enrolled. Twelve-lead electrocardiogram (ECG) was performed within 3 h after admission and repeated after 3, 5, and 7 days. Patients were classified in 2 groups: group 1 presented the maximal QTc interval length at admission and group 2 developed maximal QTc interval length after admission. Results Mean admission QTc interval was 493 ± 71 ms and mean QTc peak interval was 550 ± 76 ms (P
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- 2017
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35. Thermal behavior of the optical transition radiation screens for the ELI-NP Compton Gamma source
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D. Alesini, Massimo Ciambrella, V. Lollo, Alessandro Variola, Luigi Palumbo, Fara Cioeta, Alessandro Cianchi, Valerio Pettinacci, Luigi Pellegrino, Enrica Chiadroni, Cristina Vaccarezza, Anna Giribono, Marco Marongiu, and Andrea Mostacci
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Nuclear and High Energy Physics ,Brightness ,Compton Gamma Source, Optical Transition Radiation, Thermal Issue ,02 engineering and technology ,Compton Gamma Source ,Radiation ,01 natural sciences ,Optics ,0103 physical sciences ,Thermal ,Instrumentation ,Physics ,Luminosity (scattering theory) ,Interaction point ,010308 nuclear & particles physics ,business.industry ,Thermal Issue ,Settore FIS/01 - Fisica Sperimentale ,021001 nanoscience & nanotechnology ,Optical Transition Radiation ,Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) ,Bunches ,Physics::Accelerator Physics ,Optical radiation ,0210 nano-technology ,business ,Beam (structure) - Abstract
A high brightness electron Linac is being built in the Compton Gamma Source at the ELI Nuclear Physics facility in Romania. To achieve the design luminosity, a train of 32, 16 ns spaced, bunches with a nominal charge of 250 pC will collide with the laser beam in the interaction point. Electron beam spot size is measured with optical transition radiation profile monitors. In order to measure the beam properties along the train, the screens must sustain the thermal stress due to the energy deposited by the bunches; moreover, the optical radiation detecting system must have the necessary accuracy and resolution. This paper deals with the analytical studies as well as numerical simulations to investigate the thermal behavior of the screens impinged by the nominal bunch; the design and the performance of the optical detection line is discussed as well. In particular with the numerical simulations the behavior of the aluminum and silicon under thermal stress can be studied. The simulations allow us to see how the heat spreads on the OTR screen and frame, and what are their deformations during the heating.
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- 2017
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36. Las historias de vida en el método de planificación pastoral ver-juzgar-actuar
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Luigi Pellegrino
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060303 religions & theology ,Philosophy ,05 social sciences ,Religious studies ,050109 social psychology ,06 humanities and the arts ,0603 philosophy, ethics and religion ,autobiografía ,ver-juzgar-actuar ,historias de vida ,0501 psychology and cognitive sciences ,método pastoral ,Planificación - Abstract
Es bien conocido el aprecio que desde hace tiempo tiene la Iglesia por el método ver-juzgar-actuar, sin embargo, las reflexiones de la filosofía y la sociología hacen considerar hoy la necesidad de enriquecer el momento del ver, con unos elementos fenomenológicos y hermenéuticos que lo hagan más histórico y menos objetivista y de lograr además una mayor interacción entre los tres momentos. En este sentido, la investigación propone la inserción de las historias de vida de las personas y las comunidades como un camino nuevo de conocimiento de la realidad. En efecto, la realidad no sólo consiste en el hecho desnudo, sino también en el hecho tal y como lo percibe el sujeto; no sólo es suceso, sino también narración. Así, las historias de vida, y el consecuente método autobiográfico constituyen, según la investigación, un recurso vital en la planificación pastoral; no simplemente un apéndice secundario o un recurso simplemente aplicativo, sino, un momento intrínseco de la reflexión y de la experiencia teológica y pastoral.
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- 2017
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37. Test Procedure and Description for System Testing
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Quoc Tuan Tran, Thomas Strasser, P. Teimourzadeh Baboli, Luigi Pellegrino, Henning Taxt, Kai Heussen, Davood Babazadeh, Tue Vissing Jensen, Panos Kotsampopoulos, Julia Merino, Evangelos Rikos, Van Hoa Nguyen, A. Moghim Khavari, and Merkebu Z. Degefa
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Smart grid ,Test procedures ,Computer science ,Order (business) ,System testing ,Plan (drawing) ,Reliability engineering ,Test (assessment) - Abstract
In order to systematically plan, specify, and execute system-level test for smart grids in a cyber-physical and multi-domain manner, the ERIGrid holistic testing approach is introduced. Also, the corresponding test description and templates are discussed.
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- 2020
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38. Temporary transvenous cardiac pacing: a survey on current practice
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Antonio Rossillo, Renato Pietro Ricci, Enrico Chieffo, Massimo Zoni Berisso, Igor Diemberger, Daniela Dugo, Maurizio Landolina, Fabrizio Guarracini, Giulia Massaro, Giuseppe Boriani, Francesco Perna, Roberto De Ponti, Pier Luigi Pellegrino, Diemberger I., Massaro G., Rossillo A., Chieffo E., Dugo D., Guarracini F., Pellegrino P.L., Perna F., Landolina M., De Ponti R., Berisso M.Z., Ricci R.P., and Boriani G.
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Bradycardia ,Pacemaker, Artificial ,medicine.medical_specialty ,Cardiac pacing ,MEDLINE ,030204 cardiovascular system & hematology ,Standard procedure ,temporary transvenous cardiac pacing ,03 medical and health sciences ,Cardiologists ,0302 clinical medicine ,current clinical practice ,interventional cardiologists ,Italian survey ,prevention of complications ,interventional cardiologist ,medicine ,Humans ,030212 general & internal medicine ,Healthcare Disparities ,Practice Patterns, Physicians' ,prevention of complication ,business.industry ,Cardiac Pacing, Artificial ,General Medicine ,Advanced Atrioventricular Block ,Italy ,Current practice ,Health Care Surveys ,Emergency medicine ,Cardiac Electrophysiology ,medicine.symptom ,Electrophysiologic Techniques, Cardiac ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Temporary transvenous cardiac pacing (TTCP) is a standard procedure in current practice, despite limited coverage in consensus guidelines. However, many authors reported several complications associated with TTCP, especially development of infections of cardiac implantable electronic devices (CIED). The aim of this survey was to provide a country-wide picture of current practice regarding TTCP. Methods Data were collected using an online survey that was administered to members of the Italian Association of Arrhythmology and Cardiac Pacing. Results We collected data from 102 physicians, working in 81 Italian hospitals from 17/21 regions. Our data evidenced that different strategies are adopted in case of acute bradycardia with a tendency to limit TTCP mainly to advanced atrioventricular block. However, some centers reported a greater use in elective procedures. TTCP is usually performed by electrophysiologists or interventional cardiologists and, differently from previous reports, mainly by a femoral approach and with nonfloating catheters. We found high inhomogeneity regarding prevention of infections and thromboembolic complications and in post-TTCP management, associated with different TTCP volumes and a strategy for management of acute bradyarrhythmias. Conclusion This survey evidenced a high inhomogeneity in the approaches adopted by Italian cardiologists for TTCP. Further studies are needed to explore if these divergences are associated with different long-term outcomes, especially incidence of CIED-related infections.
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- 2020
39. From Scenarios to Use Cases, Test Cases and Validation Examples
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Dimitris T. Lagos, Kai Heussen, Panos Kotsampopoulos, Henning Taxt, Kari Mäki, Anna Kulmala, Evangelos Rikos, Oliver Gehrke, Luigi Pellegrino, Julia Merino, Merkebu Z. Degefa, Carlo Sandroni, and M. Rossi
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Test case ,business.industry ,Computer science ,Context (language use) ,Use case ,Artificial intelligence ,System validation ,business ,Machine learning ,computer.software_genre ,computer - Abstract
Selected validation scenarios and corresponding test cases in the context of the ERIGrid project are presented in this chapter. Furthermore, the benefits of using the ERIGrid validation method and testing tools are discussed on the realized system validation examples.
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- 2020
40. Erratum to: EuPRAXIA Conceptual Design Report – Eur. Phys. J. Special Topics 229, 3675-4284 (2020), https://doi.org/10.1140/epjst/e2020-000127-8
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Arie Zigler, Manuel Kirchen, Ruggero Ricci, Javier Resta-López, Eléonore Roussel, Dario Giove, A. Ghaith, Arie Irman, Vladyslav Libov, J. M. Dias, Fabio Villa, Fabrizio Bisesto, Augusto Marcelli, Bruno Buonomo, Matteo Vannini, R. Pattathil, Wim Leemans, S. Jaster-Merz, Audrey Beluze, G. C. Bussolino, Anna Giribono, Riccardo Pompili, P. Lee, Farzad Jafarinia, A. Del Dotto, Alberto Marocchino, Oscar Jakobsson, J. Scifo, R. Fiorito, Mathieu Valléau, Constantin Haefner, T. L. Audet, T. Spinka, Ujjwal Sinha, P. Santangelo, Carsten Welsch, F. Mathieu, Z. Mazzotta, Barbara Marchetti, M. A. Pocsai, Lucia Sabbatini, L. Labate, Silvia Morante, S. Romeo, Alberto Bacci, T. Heinemann, Francesco Filippi, Angelo Biagioni, A. F. Habib, D. Ullmann, Axel Bernhard, M. Artioli, Craig W. Siders, Sergio Cantarella, Alessandro Gallo, D. Kocon, C. A. Lindstrøm, Ulrich Dorda, M. Croia, Sally Wiggins, E. N. Svystun, Gabriele Tauscher, Suming Weng, Francesco Iungo, F. Massimo, Malte C. Kaluza, A. Ghigo, P. A. Walker, Fernando Brandi, Vladimir Shpakov, Anke-Susanne Müller, Ricardo Fonseca, Marie-Emmanuelle Couprie, Luca Piersanti, D. Khikhlukha, Guoxing Xia, Olle Lundh, Brendan A. Reagan, Stuart Mangles, Y. Zhao, S. Vescovi, D. Alesini, Brigitte Cros, Sergey Mironov, Andreas Lehrach, Zulfikar Najmudin, Fabrice Marteau, Oliver Karger, Kevin Cassou, Tomonao Hosokai, Markus Büscher, Vittoria Petrillo, Thomas C. Galvin, Geetanjali Sharma, C. D. Murphy, R. Walczak, Paul Crump, G. Di Pirro, Min Chen, R. Torres, A. Aschikhin, Emily Sistrunk, G. Di Raddo, Lucas Schaper, L. O. Silva, Zheng-Ming Sheng, M. Del Franco, Guido Toci, G. Kirwan, Alessandro Cianchi, Florian Grüner, M. Yabashi, Chan Joshi, Andy J. Bayramian, Marco Diomede, J. L. Paillard, Simona Incremona, Giovanni Franzini, Adolfo Esposito, D. Di Giovenale, Agustin Lifschitz, F. Falcoz, Alessandro Vannozzi, Kristjan Poder, Bernhard Holzer, Nicolas Delerue, Serge Bielawski, Olena Kononenko, Alvin C. Erlandson, G. Korn, J. Cowley, R. Brinkmann, Imre Ferenc Barna, Gaetano Fiore, Luca Serafini, Dino A. Jaroszynski, C. Simon, Enrica Chiadroni, M. Rossetti Conti, Francesco Stellato, D. Pugacheva, M. Ibison, R. Rossmanith, A. Beck, Alexandra Alexandrova, Paul Mason, Jun Zhu, Andrew Sutherland, Gianluca Sarri, Yang Li, Fabien Briquez, R. D'Arcy, Charles Kitegi, Klaus Ertel, Claes-Göran Wahlström, M. Hübner, Leonida A. Gizzi, Tamina Akhter, D. R. Symes, Stefan Karsch, A. Nutter, P. Delinikolas, J. A. Clarke, Paul Scherkl, Antonio Falone, C. Le Blanc, P. Campana, A. Martinez de la Ossa, Jason Cole, Marco Bellaveglia, G. Costa, Maria Pia Anania, Massimo Ferrario, M. J. V. Streeter, Nikolay Andreev, Konstantin Kruchinin, Ke Wang, M. H. Bussmann, Grace Manahan, Gilles Maynard, Igor Andriyash, I. Kostyukov, Dimitris N. Papadopoulos, Wei Lu, Christophe Simon-Boisson, A. Mosnier, F. Brottier, Barbara Patrizi, Alessandro Stecchi, A. Ferran Pousa, Bernhard Hidding, S. De Nicola, J. Wolfenden, Federico Nguyen, A. Y. Molodozhentsev, D. Oumbarek Espinos, Simon M. Hooker, A. Helm, Paolo Tomassini, A. Chancé, Hao Zhang, Phu Anh Phi Nghiem, A. Welsch, L. Pribyl, Christophe Szwaj, Joana Luis Martins, Maria Weikum, Efim A. Khazanov, Giuseppe Dattoli, Jens Osterhoff, A. Bonatto, S. Bartocci, Petra Koester, L. Boulton, Carl Schroeder, Angelo Stella, E. Di Pasquale, Cristina Vaccarezza, Davide Terzani, Victor Malka, P. Niknejadi, Andrea Mostacci, A. Petralia, Ralph Assmann, Christoph Lechner, U. Rotundo, Olivier Marcouillé, F. Cioeta, T. Silva, Luigi Pellegrino, J. Fils, X. Li, Jorge Vieira, Andreas Maier, A. Specka, Alessandro Rossi, Alexander Knetsch, Renato Fedele, Ulrich Schramm, Erik Bründermann, Vladimir Litvinenko, Marco Galimberti, Masaki Kando, and A. Beaton
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Technology ,Applied physics ,Conceptual design ,Calculus ,General Physics and Astronomy ,General Materials Science ,Physical and Theoretical Chemistry ,ddc:600 ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,GeneralLiterature_MISCELLANEOUS - Abstract
Figure 20.1 was not correct in the published article. The original article has been corrected. The published apologizes for the inconvenience.
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- 2020
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41. Aggregation of residential Energy Storage Systems
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Carlo Sandroni and Luigi Pellegrino
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Residential energy ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,02 engineering and technology ,Energy margin ,Grid ,Automotive engineering ,Energy storage ,Power (physics) ,Technical feasibility ,0202 electrical engineering, electronic engineering, information engineering ,Metre ,Pv plant - Abstract
This paper aims to perform a technical feasibility study of a Virtual Energy Storage System (VESS) composed of 1400 residential users with a PV plant and a Battery Energy Storage System (BESS). A control strategy has been developed and applied to find out the amount of grid services that the VESS is able to provide. The results show that, aggregating hundreds of residential users with a BESS, there is sufficient power and energy margin to provide grid services ensuring the services behind the meter such as the self-consumption functionality. The results of the feasibility study are quite promising: the VESS is able to provide up to 49 MWh of grid services, both upward and downward, over the day.
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- 2019
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42. Aging test protocol for Lithium-ion cells
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Luigi Pellegrino and Enrica Micolano
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Protocol (science) ,Computer science ,Test procedures ,020209 energy ,020208 electrical & electronic engineering ,chemistry.chemical_element ,02 engineering and technology ,Aging test ,Lithium-ion battery ,Reliability engineering ,chemistry ,0202 electrical engineering, electronic engineering, information engineering ,Lithium ,Test protocol - Abstract
The paper describes a test protocol developed in order to build the aging model of electrochemical accumulators and estimate the expected lifetime with different operating conditions. The test procedure has been verified performing aging tests on three lithium-ion cells. The paper presents and comments the results and provides suggestions for further aging tests on batteries.
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- 2019
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43. A reliable Energy Storage System model for the energy community management
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Luigi Pellegrino, Matteo Redaelli, and Edoardo Corsetti
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Computer science ,020209 energy ,State of energy ,Estimator ,02 engineering and technology ,Energy storage ,System model ,Reliability engineering ,Energy management system ,020401 chemical engineering ,0202 electrical engineering, electronic engineering, information engineering ,Energy community ,Microgrid ,0204 chemical engineering ,Reliability (statistics) - Abstract
This paper presents the experimental activities performed in a microgrid to demonstrate the advantages of a State of Energy (SoE) estimator for a Battery Energy Storage System (BESS) model integrated into the Energy Management System (EMS) of an energy community. The improved model of the BESS in the EMS, compared to the classical one, allows to increase the reliability of the SoE estimation, hence the results of the micro-grid management optimization.
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- 2019
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44. Improvement in Endothelium Dysfunction in Diabetics Treated with Statins: A Randomized Comparison of Atorvastatin 20 mg versus Rosuvastatin 10 mg
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BRUNETTI, NATALE DANIELE, MAULUCCI, GUGLIELMO, CASAVECCHIA, GRAZIA PIA, DISTASO, CARLO, DE GENNARO, LUISA, LUIGI PELLEGRINO, PIER, and DI BIASE, MATTEO
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- 2007
45. Catecholaminergic polymorphic ventricular tachycardia associated with sinus node dysfunction and junctional rhythm: Case report and literature review
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Matteo Di Biase, Francesco Santoro, Pier Luigi Pellegrino, Rafel Sai, Antonio Gaglione, Luigi Ziccardi, Girolamo D'Arienzo, and Natale Daniele Brunetti
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Adult ,Tachycardia ,medicine.medical_specialty ,Sinus bradycardia ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Catecholaminergic polymorphic ventricular tachycardia ,Sick sinus syndrome ,Diagnosis, Differential ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Sick Sinus Syndrome ,Evidence-Based Medicine ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Long QT Syndrome ,Anesthesia ,Tachycardia, Ventricular ,cardiovascular system ,Cardiology ,Female ,Electrical conduction system of the heart ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Junctional rhythm - Abstract
We report the case of a 38-year-old woman with history of syncope and polymorphic ventricular tachycardia; tachycardia was inducible at exercise stress test, not at electrophysiologic study. Phases of QT prolongation were found at ambulatory electrocardiogram monitoring. The woman came to our attention for periodic control of implantable loop recorder. Rest electrocardiogram at admission unexpectedly showed sinus bradycardia, junctional rhythm, and ventricular premature beats. Furthermore, loop recorder control revealed a short run of bidirectional tachycardia, not associated with syncope. Final diagnosis was catecholaminergic polymorphic ventricular tachycardia, and the patient was implanted with an ICD. We therefore report an unusual case of bidirectional ventricular tachycardia associated with sinus node dysfunction and junctional escape rhythm. We hypothesize that a diffuse dysfunction of cardiac conduction system, presumably based on diffuse disorder of calcium handling, may be responsible for both sinus node failure and ventricular tachycardia.
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- 2016
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46. Left Atrial Appendage Closure Guided by 3D Printed Cardiac Reconstruction: Emerging Directions and Future Trends
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Claudio Tondo, Pier Luigi Pellegrino, Gaetano Fassini, and Matteo Di Biase
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Appendage ,medicine.medical_specialty ,Percutaneous ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Atrial Appendage ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,Physiology (medical) ,Internal medicine ,Occlusion ,Angiography ,medicine ,Cardiology ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Cardiac catheterization - Abstract
Emerging Directions and Future Trends Introduction Percutaneous left atrial appendage (LAA) occlusion has emerged as an alternative therapeutic approach to medical therapy for stroke prevention in patients with atrial fibrillation. 3D printing is a novel technology able to create a patient specific model of any given anatomical portion of the heart. Results Herein we report the first 2 cases of LAA occlusion procedure with 2 different systems, the Wave Crest device (Coherex Medical, Inc., USA) and the Amplatzer Amulet device (St. Jude Medical, St. Paul, MN, USA), in which a 3D printed LAA model (Care Tronik, Prato, Italy) was used in a rehearse phase. Both patients had history of paroxysmal AF and previous transient ischemic attack (TIA) occurred during oral anticoagulation with correct INR. In the first patient the occlusive device was positioned within the LAA after a rehearse occlusion using the 3D printed LAA plus a 27 mm Coherex Wavecrest device, demonstrating a good compression and sealing, particularly considering a proximal lobe of the appendage. In the second patient an attempt with the 27 mm Amulet device delivered within the 3D printed LAA, based on angiography and transesophageal echocardiographic (TEE), revealed insufficient covering of the proximal part of LAA vestibule; the device was released only after a second test with the 31 mm Amulet demonstrating a good sealing. Conclusion These 2 cases demonstrated that 3D model could help in finding the correct position within LAA, sizing the device and guiding the choice of the closure device despite the measurements provided by angiography and TEE.
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- 2016
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47. Delayed ventricular pacing failure and correlations between pacing thresholds, left ventricular ejection fraction, and QTc values in a male with Takotsubo cardiomyopathy
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Luigi Ziccardi, Girolamo D'Arienzo, Natale Daniele Brunetti, Francesco Santoro, Pier Luigi Pellegrino, Rafel Sai, and Matteo Di Biase
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Male ,medicine.medical_specialty ,Time Factors ,Cardiomyopathy ,Clinical Investigations ,Action Potentials ,030204 cardiovascular system & hematology ,Chest pain ,QT interval ,Ventricular Function, Left ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Heart Rate ,Takotsubo Cardiomyopathy ,Internal medicine ,Atrial Fibrillation ,medicine ,Acute chest pain ,Humans ,cardiovascular diseases ,Treatment Failure ,Aged ,Dual Chamber Pacemaker ,Sick Sinus Syndrome ,Ejection fraction ,business.industry ,Cardiac Pacing, Artificial ,030208 emergency & critical care medicine ,Stroke Volume ,General Medicine ,Ventricular pacing ,After discharge ,medicine.disease ,Cardiology ,cardiovascular system ,Ventricular Function, Right ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND: Transient pacing failure caused by transient increased pacing threshold has been reported in patients with transient left ventricular apical dysfunction (Takotsubo cardiomyopathy [TC]). Normal pacing thresholds usually recover after normalization of systolic dysfunction. HYPOTHESIS: Pacing failure correlates with clinics of TC. METHODS: We report the case of a 76‐year‐old man with a dual chamber pacemaker, admitted for acute chest pain and dyspnea and final diagnosis of TC. One month after index admission, the patient came back complaining again of chest pain. Unexpectedly, admission electrocardiogram showed ventricular pacing failure and an increased pacing threshold. In the following weeks, pacing threshold gradually recovered with left ventricular ejection fraction and QTc values. RESULTS: Ventricular pacing threshold correlated directly to QTc values and inversely to left ventricular ejection fraction over time (P
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- 2018
48. Design, realization, and high power test of high gradient, high repetition rate brazing-free S-band photogun
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Luigi Palumbo, Alessandro Gallo, Alessandro Variola, Marco Bellaveglia, Valerio Pettinacci, V. Lollo, Antonio Battisti, Dennis Palmer, Luigi Pellegrino, Antonio Falone, Fabio Cardelli, Stefano Pioli, Luca Piersanti, and David Alesini
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Physics ,Nuclear and High Energy Physics ,Physics and Astronomy (miscellaneous) ,010308 nuclear & particles physics ,business.industry ,Particle accelerator ,Solenoid ,Surfaces and Interfaces ,Electron ,Type (model theory) ,01 natural sciences ,Cathode ,law.invention ,Radio frequency ,Room temperature ,RF Accelerators & Beams ,Optics ,law ,0103 physical sciences ,Physics::Accelerator Physics ,lcsh:QC770-798 ,Thermal emittance ,lcsh:Nuclear and particle physics. Atomic energy. Radioactivity ,010306 general physics ,business ,Realization (systems) ,Electron gun - Abstract
rf photoguns find several types of applications as high brightness electron sources for free-electron lasers, energy recovery linacs, Compton and Thomson sources, and high-energy linear colliders. The high peak current and low transverse emittance of the generated beam are obtained with the combination of a high peak electric field ($g100\text{ }\text{ }\mathrm{MV}/\mathrm{m}$) at the cathode surface, a proper choice of the solenoid field around, or immediately after, the gun, and special fabrication and treatments of the cathode itself. On the other hand, to increase the average electron current, a high repetition rate ($g100\text{ }\text{ }\mathrm{Hz}$) and/or a multibunch rf gun have to be developed. These types of devices are, in general, fabricated by brazing processes of copper machined parts. The brazing processes require a large vacuum furnace, are very expensive, and pose a not negligible risk of failure. A new fabrication technique for this type of structure has been recently developed and implemented at the Laboratories of Frascati of the National Institute of Nuclear Physics (INFN-LNF, Italy) and already applied to an rf gun now operating at a relatively low cathode peak field and low repetition rate [D. Alesini et al., Phys. Rev. Accel. Beams 18, 092001 (2015)]. It is based on the use of special rf-vacuum gaskets that allow a brazing-free realization process. The $S$-band gun of the Extreme Light Infrastructure-Nuclear Physics Gamma Beam System, under construction in Magurele (Bucharest, Romania), has been realized with this new technique and represents a further and fundamental step toward the consolidation of this technology for high gradient particle accelerator fabrication. It operates at 100 Hz with a $120\text{ }\text{ }\mathrm{MV}/\mathrm{m}$ cathode peak field and $1.5\text{\ensuremath{-}}\ensuremath{\mu}\mathrm{s}$-long rf pulses to house the 32 bunches necessary to reach the target gamma flux. High gradient tests, performed at full power and a full repetition rate, have shown the extremely good performances of the structure in terms of the breakdown rate and conditioning time and definitively demonstrated the reliability and suitability of such fabrication process for high gradient structure realization. In this paper, we report and discuss the electromagnetic and thermomechanical design, the realization process, and all the experimental results at low and high power at a full repetition rate.
- Published
- 2018
49. New State of Energy estimator for a lead-acid battery
- Author
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Gianluca Alimonti, Matteo Redaelli, and Luigi Pellegrino
- Subjects
business.industry ,Computer science ,Control theory ,020209 energy ,Computer data storage ,State of energy ,0202 electrical engineering, electronic engineering, information engineering ,Estimator ,02 engineering and technology ,State (computer science) ,business ,Lead–acid battery ,Electrochemical energy storage - Abstract
The article describes a new State of Energy estimator that can be applied to an electrochemical Energy Storage System. The developed estimator was tested on a lead-acid storage system, already aged, connected to a real micro-grid. The results show an accuracy four times better than the state of the art, in particular its average error is 6%.
- Published
- 2018
- Full Text
- View/download PDF
50. Energetic and economical analysis for a LVDC residential district
- Author
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Luigi Pellegrino, Riccardo Lazzari, and Fabio Almasio
- Subjects
0209 industrial biotechnology ,business.industry ,Computer science ,020208 electrical & electronic engineering ,Direct current ,Context (language use) ,02 engineering and technology ,Converters ,Grid ,Energy storage ,law.invention ,Reliability engineering ,Renewable energy ,020901 industrial engineering & automation ,law ,Distributed generation ,0202 electrical engineering, electronic engineering, information engineering ,business ,Alternating current - Abstract
Distributed generation, energy storage systems and a growing number of loads are interfaced to the grid through power electronic converters. In this context, a distributed system in direct current could guarantee advantages from different points of view. This paper assesses, through an analytical study, the energetic and economic savings achievable by the adoption of a low voltage direct current distribution grid in order to replace the traditional grid in alternating current to supply a residential district. According to the analyses carried out appears that the benefits achievable by the adoption of distributed grids in direct current are reduced from energy and economic point of view. The economic benefits occur for the single user when the distribution grid, starting from secondary substation, is completely in direct current. This causes an higher cost for the distribution system operator in the realization of the secondary substation, where must be installed a suitable power converter. The distribution system operator could however achieve many benefits from technical point of view because the adoption of distributed grids in direct current allows a better and simple integration of renewable sources and storage systems.
- Published
- 2018
- Full Text
- View/download PDF
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