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Cristina Lalmolda,1,2 Pablo Flórez,1 Marta Corral,3 Ana Hernández Voth,3 Carles Grimau,1 Javier Sayas,2 Manel Luján1,2,4 1Pneumology Department, Corporació Sanitària I Universitària Parc Taulí, Sabadell, Barcelona, Spain; 2CIBERES, Centro de Investigación Biomédica en red, Mallorca, Spain; 3Pneumology Department, Hospital 12 de Octubre, Madrid, Spain; 4Universitat Autònoma de Barcelona, Bellaterra, Barcelona, SpainCorrespondence: Manel LujánPneumology Department, Corporació Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí 1, 08208 Sabadell, Campus de la UAB, Plaça Cívica, Bellaterra, 08193, Barcelona, SpainTel +34937231010Email mlujan@tauli.catPurpose: The European Task Force for chronic non-invasive ventilation in stable COPD recommends the use of high pressure-support (PS) level to maximize the decrease in PaCO2. It is possible that the ventilator model can influence the need for higher or lower pressure levels.Research Question: To determine the differences between ventilators in a bench model with an increased inspiratory demand; and to compare the degree of muscular unloading measured by parasternal electromyogram (EMGpara) provided by the different ventilators in real patients with stable COPD.Patients and Methods: Bench: four levels of increasing progressive effort were programmed. The response of nine ventilators to four levels of PS and EPAP of 5 cm H2O was studied. The pressure-time product was determined at 300 and 500 msec (PTP 300/500).Clinical Study: The ventilators were divided into two groups, based on the result of the bench test. Severe COPD patients with non-invasive ventilation (NIV) were studied, randomly comparing the performance of one ventilator from each group. Muscle unloading was measured by the decrease in EMGpara from its baseline value.Results: There were significant differences in PTP 300 and PTP 500 in the bench study. Based on these results, home ventilators were classified into two groups; group 1 included four models with higher PTP 300. Ten COPD patients were recruited for the clinical study. Group 1 ventilators showed greater muscle unloading at the same PS than group 2.Conclusion: The scale of pressure support in NIV for high intensity ventilation may be influenced by the ventilator model.Clinical Trials.gov: NCT03373175.Keywords: chronic obstructive pulmonary disease, parasternal electromyogram, pressure support, pressure-time product, respiratory muscle unloading, rise time

El presente trabajo se realizó en el arroyo El Chacay y en el río Las Albahacas desde la primavera de 1999 hasta la primavera de 2000. El objetivo de esta investigación fue comparar la composición y abundancia de la comunidad diatómica en ríos y arroyos serranos de la cuenca del río Piedra Blanca, durante un ciclo anual. En total, 121 taxa (especies, variedades y formas) fueron registrados a partir del análisis taxonómico. El orden Pennales predominó en número de especies y porcentaje de frecuencia relativa. El género con mayor número de especies fue Navicula. El número de especies osciló entre un mínimo de 21 en invierno de 2000 en el río Las Albahacas (aguas arriba del balneario) y un máximo de 49 en verano de 2000 en el arroyo El Chacay y en primavera de 2000 en el río Las Albahacas (aguas arriba del balneario), respectivamente. El mayor número de especies corresponde a los menores porcentajes de frecuencia. La densidad osciló entre 1 org.ml-1 en otoño de 2000 en el río Las Albahacas, aguas arriba del balneario y 1596,40 org.ml-1 registrados en primavera de 1999 en el arroyo El Chacay. Los parámetros fisicoquímicos y la composición de especies determinaron una mayor afinidad entre los sitios en la estación de primavera.The present work was developed in El Chacay Creek and Las Albahacas River from 1999 spring to 2000 spring. The aim of this investigation was to compare the composition and abundance of the diatom communities of a highland water stream and a river within the Piedra Blanca River basin, during an annual cycle. As a result of a taxonomic analysis a total of 121 taxa (species, varieties and forms) were recorded. The Order Pennales predominated in number of species and relative frequency. The genus with the highest number of species was Navicula. The total number of species varied from a minimum of 21 in 2000 winter season in the Las Albahacas River (upstream riverside resort) to a maximun of 49 in 2000 summer in the El Chacay Creek and during 2000 spring in the Las Albahacas River (upstream riverside resort) respectively. The occurrence of a number of species with low frequency was noticed. The density varied from a minimun of 1 org.ml-1 in 2000 fall in the Las Albahacas River, upstream riverside resort, to a maximum of 1596,4 org.ml-1 in 1999 spring at El Chacay Creek. The physical and chemical factors as well as the species composition, a more similarity was found for the spring season in all studied spots.

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In recent decades, recommendations on dietary protein content have been considerably reduced, while fibre content has been increased. Under these conditions, an adequate dietary amino acid balance could be crucial to optimise feed efficiency. Plasma urea nitrogen (PUN) level could be a good indicator of an amino acid imbalance and its potential has already been studied in other species, but not yet in rabbits. The main objective of the present work was to detect the possible interest of PUN in pinpointing amino acid deficiencies in rabbits. Two experimental diets were formulated from the same basal mixture, following all the recommendations for growing rabbits, except lysine, whose content was variable, following current guidelines in diet P8.1 or lower from those in P4.4 (with 8.1 and 4.4 g/kg dry matter of lysine and with 757 and 411 mg of lysine per MJ of digestible energy). Three different trials were designed: one where the animals were fed ad libitum (AL) and two others in which fasting periods of 10 h were included; one where feeding was restored at 08:00 h (Fast8h) and the other at 18:00 h (Fast18h). A total of 72 three-way crossbred growing rabbits (24 animals for each trial in a split-plot trial) up to a total of 12 recordings were used. Blood samples were taken every 4 h in AL trial and every hour after refeeding up to a total of six controls, in trials Fast8h and Fast18h. The differences between balanced and unbalanced diets in lysine were highest (P<0.001) between 04:00 h and 12:00 h in animals fed ad libitum, and at 3 h after refeeding (21:00 h) in Fast18h. These results suggest that PUN could be an adequate indicator to detect deficiencies in amino acids in growing rabbit diets. [ABSTRACT FROM AUTHOR]