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Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC.

Background: This audit provides baseline data on the prevalence, testing pattern and yield of electrophoresis tests performed over a 6-year period in a tertiary academic China hospital. To evaluate the adequacy of the electrophoresis test request. Methods: This was a retrospective audit of all SPE, UPE and IFE tests performed on new and follow-up adult patients (aged ≥18 years) from 2014 to 2019, using data from the Department of Laboratory Science of Jiangsu Province Hospital laboratory information system database. Results: A total of 47,940 cases of electrophoresis, there are 15,473 cases SPE tests (of which 25.6% were follow-up tests); have 12,531 cases UPE tests (10.2% of the tests were follow-up tests); have 19,327 cases SIFE tests (31.6% of which were follow-up tests). Hematology was the highest rate of submission and positive. SPE testing before IFE tests can effectively increase the positive rate of IFE. Conclusion: This audit provides baseline data on the prevalence of test requests, their source and the yield of electrophoresis testing in our laboratory. An increasing trend in SIFE and UIFE was evident.

Objective: Recently, the incidence of MM (Multiple myeloma, MM) in the elderly has gradually increased. We explored the diagnosis efficiency of urine light chain ratio combined with immunofixation electrophoresis for preliminary screening elderly MM patients who had renal injury as the first symptom. Methods: A total of 981 elderly outpatients, newly diagnosed with renal injury, in our hospital from January 2017 to February 2019 were retrospectively reviewed. According to the results of immunofixation electrophoresis, they were divided into M-protein group and non-M-protein group. The laboratory test data of each group were collected. Results: Among the 981 enrolled cases, 84 cases were in the M-protein group, accounting for 8.6%. There was no statistically significant difference in Crea and eGFR between the M-protein group and the non-M-protein group. The KAP/LAM ratio was higher in the non-M group then that in the M-protein group with LAM type light chain expression, and was lower in the M-protein group with KAP type light chain expression (PP Conclusion: Urine light chain ratio had a higher specificity for initial screening of elderly MM patients with renal injury as the first symptom. It could reflect the degree of monoclonal proliferation. Moreover, it was easy to be accepted by patients and suitable for health checkup or preliminary screening of suspected MM patients.

The endocrine system is the collection of glands that produce hormones that regulate metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood. In human beings, the major endocrine glands are the thyroid gland and the adrenal glands. In all vertebrates, the hypothalamus is the neural control center for all endocrine systems. Several glands that signal each other successively are usually referred to as axis. Besides, many other organs that are part of other body systems, including bone, pancreas, kidney, liver, heart, and gonads, have secondary endocrine functions.

Immunoglobulin G4-related disease (IgG4-RD) is a chronic progressive autoimmune disease. Mammary gland, parotid gland and orbit involvement in IgG4-RD is extremely rare. Herein, we report a case of IgG4-RD presenting with pain in breasts, parotid masses and bilateral exophthalmos. A 52-year-old woman came to our breast disease clinic for treatment, because of pain in her breasts. After examination, eliminated the possibility of breast cancer. Physical examination indicated bilateral parotid hypertrophy and a small amount of clear liquid flowed out while pressed lightly, space-occupying lesions in the upper and outer orbits of the both eyes, this condition had been existing for 6 years. The results of immunohistochemical staining indicated IgG4-positive plasma cells in parotid masses and laboratory tests revealed elevated serum IgG4 (1480 mg/dL, normal range: 3-201 mg/dL), a diagnosis of IgG4-RD of the mammary gland, parotid gland and orbit was formulated.

To meet the needs of management of medical case information and biospecimen simultaneously, we developed a novel medical case information system integrating with biospecimen management. The database established by MS SQL Server 2000 covered, basic information, clinical diagnosis, imaging diagnosis, pathological diagnosis and clinical treatment of patient; physicochemical property, inventory management and laboratory analysis of biospecimen; users log and data maintenance. The client application developed by Visual C++ 6.0 was used to implement medical case and biospecimen management, which was based on Client/Server model. This system can perform input, browse, inquest, summary of case and related biospecimen information, and can automatically synthesize case-records based on the database. Management of not only a long-term follow-up on individual, but also of grouped cases organized according to the aim of research can be achieved by the system. This system can improve the efficiency and quality of clinical researches while biospecimens are used coordinately. It realizes synthesized and dynamic management of medical case and biospecimen, which may be considered as a new management platform.