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This paper aims to construct an evaluation index system for the transformation and development of application-oriented undergraduate colleges based on improving the ability of social service, in order to provide reference for application-oriented undergraduate colleges and universities to help them better carry out transformation and development. This paper constructs an evaluation index system for the transformation and development of application-oriented undergraduate colleges based on improving social service ability. The index system includes 11 indicators in four aspects: social service ability, teacher team construction, school-enterprise cooperation and innovation and entrepreneurship education. Finally, this paper assigns and analyzes the index system, and puts forward the improvement measures of applied undergraduate colleges in different indicators. The research conclusion of this paper will help applied undergraduate colleges to better understand the current situation and problems of their transformation and development, and provide reference and guidance for them to further improve their social service ability and transformation and development level.

The purpose of this study is to explore the internal relationship between the transformation development of new application-oriented undergraduate colleges and the enhancement of social service ability. Firstly, the paper analyzes the factors influencing the transformation and development of new application-oriented undergraduate colleges from the aspects of discipline construction, teaching quality and scientific research ability, innovation ability and internationalization degree. Secondly, it analyzes the importance of improving social service ability from the aspects of serving society, promoting the cooperation between industry, university and research, and transforming scientific and technological achievements. Furthermore, the paper puts forward the internal correlation between the transformation and development of newly built application-oriented undergraduate colleges and universities and the improvement of social service ability, that is, by improving teaching quality and scientific research ability, enhancing innovation ability and internationalization degree, newly built application-oriented undergraduate colleges and universities can improve their comprehensive strength and competitiveness, and thus improve the ability to serve the society. At the same time, improving the ability of social service can further promote the transformation and development of newly built application-oriented undergraduate colleges, promote the cooperation between production, university and research, transform scientific research results into technologies and products with practical application value, and make greater contribution to the development of local economy. Finally, it puts forward corresponding policy suggestions, including increasing policy and financial support, optimizing discipline structure, strengthening industry-university-research cooperation, and establishing evaluation mechanism and incentive mechanism, so as to promote the transformation and development of newly built application-oriented undergraduate colleges and universities and improve their social service ability.

The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patients. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS.

This study was conducted to evaluate effects of dietary Mulberry leaves on growth performance, carcass traits and meat quality in finishing pigs. Here, a total of 72 crossbred [(Landrace × Yorkshire) × Duroc] pigs with an average initial body weight of 70.03 ± 0.48 kg were used in this 45-day feeding trial. The pigs were randomly divided into three groups (6 pigs/pen and 4 replicates/group). Dietary treatments included a control diet (without any Mulberry leaves) and diets supplemented with 5% non- or fermented Mulberry leaf powder (MF or FMF respectively). The present findings indicated that compared with the control group, administration of MF or FMF significantly improved gain: feed ratio (p < .05) and reduced the backfat thickness (p < .05). Meanwhile, dietary MF and FMF significantly enhanced triglyceride deposition in Longissimus dorsi muscles (p < .05). Besides, both of MF and FMF could effectively improve the antioxidant capacity by increasing the content of T-AOC and SOD in serum and reduce the rancidity of pork. In conclusion, supplementary MF and FMF could promote gain: feed ratio, reduce backfat thickness, increase fat deposition in muscle and reduce the rancidity of pork.

Fermentation has attracted increasing attention in pig industry, because of low costs and numerous benefits on pig growth and health as well as environmental improvement, although the mechanisms remain largely unknown. In the present study, fermented corn-soybean meal significantly improved average daily gain and gain:food ratio (P < 0.05). Fermented feed (FF) significantly increased insulin-like growth factor 1 (IGF1) transcription in liver (P < 0.05). Meanwhile, fermented meal significantly enhanced the binding of CCAAT/enhancer-binding protein beta (C/EBPβ) to IGF1 promoter and C/EBPβ expression in liver (both P < 0.05). FF tended to increase IGF1 proteins in liver and serum too (both 0.05 < P < 0.10). Meanwhile, FF slightly but significantly increased hepatic and circulating triglyceride and total cholesterol levels, as well as serum ratio of high-density to low-density cholesterol (all P < 0.05). Our data indicated that FF could significantly augment the binding of C/EBPβ to IGF1 promoter and promote hepatic IGF1 expression and production, thus boost pig growth.

Fermented corn-soybean meal (fermented feed, FF) is commonly used in swine production, but the effects of FF on gut health remain unclear. In this study, serum immunity, mRNA abundances of antimicrobial peptides (AMPs) and Toll-like receptors (TLR1-9), bacterial abundance in the duodenum and colon, and colonic metabolic phenotypes were determined in crossbred barrows (Duroc × Landrace × Large White) fed FF or normal feed (unfermented feed, UF) (n = 6). When compared to the UF group, the results showed that serum levels of IgG and IgM were significantly increased in FF group pigs (P < 0.05). FF significantly decreased the abundances of Bacteroides and Verrucomicrobia in the duodenum and decreased the abundances of Bacteroides, Proteobacteria, and Verrucomicrobia in the colon while it significantly increased the abundances of Firmicutes and Actinobacteria (P < 0.05). Furthermore, a Spearman’s correlation analysis showed that serum immunity and the expression of genes related to gut immunity were associated with bacterial strains at the family level. Moreover, differentially abundant colonic microbiota were associated with colonic metabolites. LC-MS data analyses identified a total of 1,351 metabolites that markedly differed between the UF and FF groups. C5-Branched dibasic acid metabolism was significantly upregulated whereas the purine metabolism was significantly downregulated (P < 0.05) in the colonic digesta of pigs in the FF meal group compared to the UF meal group. Collectively, these results indicated that FF meal could influence serum immunity and the expression of genes related to gut immunity, correlating with the gut microbiota and bacterial metabolites in grower-finisher pigs. This study may provide an alternative strategy for improving the intestinal health of grower-finisher pigs.

Mulberry leaves are the dry leaves of Morus nigra L. trees, which are widely cultivated in central and southern China. Mulberry has a long history of medicinal use, such as anti-stress, lowering blood glucose and anti-obesity.Explore the effects of mulberry leaves on fat deposition as well as the underlying mechanisms.Total of 48 fattening pigs weighing about 70 kg were randomly allotted to normal diet or die supplemented with 5% (w/w) mulberry leave powder. Changes of fat mass, indicated by backfat thickness was measured with Piggyback tester, blood triglyceride and cholesterol were tested using commercial biochemical kits, serum hormones were estimated by ELISA, and leptin-related signaling activity were assessed using western-blot.Supplementation with Mulberry leaf feed (MF) significantly reduced serum triglyceride and free cholesterol concentrations and increased the ratio of high-density lipoprotein cholesterol (HDL-c) to low-density lipoprotein cholesterol (LDL-c), while serum glucose and free fatty acids remained unchanged. Dietary MF resulted in a significant reduction in the size of adipocytes and backfat thickness (P 0.05). Accordingly, hormone-sensitive lipase (HSL) in backfat was significantly up-regulated and fatty acid synthase (FAS) was down-regulated by MF supplementation (both P 0.05). Furthermore, MF supplementation significantly elevated circulating leptin and adiponectin without influencing serum insulin and glucocorticoid. Moreover, significantly higher leptin receptor (Leptin-R) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) were detected in MF-supplemented pigs, suggesting an enhanced leptin signaling induced by MF in the subcutaneous fat.Mulberry leaves have obvious anti-obesity effects, providing a theoretical basis for the development of mulberry leaves as a drug against obesity.

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Fermentation has attracted increasing attention in pig industry, because of low costs and numerous benefits on pig growth and health as well as environmental improvement, although the mechanisms remain largely unknown. In the present study, fermented corn-soybean meal significantly improved average daily gain and gain:food ratio (P < 0.05). Fermented feed (FF) significantly increased insulin-like growth factor 1 (IGF1) transcription in liver (P < 0.05). Meanwhile, fermented meal significantly enhanced the binding of CCAAT/enhancer-binding protein beta (C/EBPβ) to IGF1 promoter and C/EBPβ expression in liver (both P < 0.05). FF tended to increase IGF1 proteins in liver and serum too (both 0.05 < P < 0.10). Meanwhile, FF slightly but significantly increased hepatic and circulating triglyceride and total cholesterol levels, as well as serum ratio of high-density to low-density cholesterol (all P < 0.05). Our data indicated that FF could significantly augment the binding of C/EBPβ to IGF1 promoter and promote hepatic IGF1 expression and production, thus boost pig growth.

With the accelerated process of globalization and the knowledge economy, cultural -creative industries in many countries or regions become the pillar industries reflecting the comprehensive competitiveness and economic and social development. Through the use of PLS path analysis, multidimensional perspective analysis of the policy implications related to how the development of cultural- creative industries affected areas and to verify the potential role for the regional development by cultural-creative industries. Starting from the interaction between cultural- creative industries and regional development, a theoretical model which reveals the role of cultural-creative industries on regional development was established.