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23 results on '"Lulla, Anju"'

4. Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites

Author

Chakraborty, Saroj, primary, Lulla, Anju, additional, Cheng, Xi, additional, Yeo, Ji-Youn, additional, Mandal, Juthika, additional, Yang, Tao, additional, Mei, Xue, additional, Saha, Piu, additional, Golonka, Rachel M., additional, Yeoh, Beng San, additional, Mell, Blair, additional, Jia, Wei, additional, Putluri, Vasanta, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Putluri, Nagireddy, additional, Sreekumar, Arun, additional, Meyer, Katie, additional, Vijay-Kumar, Matam, additional, and Joe, Bina, additional

Published
2023
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12. Batch effects removal for microbiome data via conditional quantile regression (ConQuR)

Author

Ling, Wodan, primary, Zhao, Ni, additional, Lulla, Anju, additional, Plantinga, Anna M., additional, Fu, Weijia, additional, Zhang, Angela, additional, Liu, Hongjiao, additional, Li, Zhigang, additional, Chen, Jun, additional, Randolph, Timothy, additional, Koay, Wei Li A., additional, White, James R., additional, Launer, Lenore J., additional, Fodor, Anthony A., additional, Meyer, Katie A., additional, and Wu, Michael C., additional

Published
2021
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13. Physical activity and diet associations with the gut microbiota in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Author

Memili, Aylin, Lulla, Anju, Liu, Hongwei, Shikany, James M., Jacobs, David R., Langsetmo, Lisa, North, Kari E., Jones, Corbin, Launer, Lenore J., and Meyer, Katie A.

Abstract

Gut microbiota may influence metabolic pathways related to chronic health conditions. Evidence for physical activity and diet influences on gut microbial composition exists, but data from diverse population-based cohort studies are limited.

Published
2023
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14. SEX AND SALT-RESPONSIVE CONJUGATION OF BILE ACIDS BY THE HOLOBIONT REGULATES HYPERTENSION

Author

Chakraborty, Saroj Chakrabort, primary, Lulla, Anju, additional, Cheng, Xi, additional, Mccarthy, Cameron G, additional, Yeo, Ji-Youn, additional, Alimadadi, Ahmad, additional, Mandal, Juthika, additional, Saha, Piu, additional, Yeoh, Beng San, additional, Louis, Evangelina F, additional, Mell, Blair, additional, Jia, Wei, additional, Wenceslau, Camilla F, additional, Vijay-Kumar, Matam, additional, Meyer, Katie, additional, and Joe, Bina, additional

Published
2021
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15. Abstract P238: Bile Acid Metabolites Modulate Hypertension

Author

CHAKRABORTY, Saroj, primary, Lulla, Anju, additional, Cheng, Xi, additional, McCarthy, Cam, additional, Yeo, Ji-Youn, additional, Mandal, Juthika, additional, Alimadadi, Ahmad, additional, Saha, Piu, additional, Yeoh, Beng San, additional, Mell, Blair, additional, Jia, Wei, additional, Putluri, Vasanta, additional, Putluri, Nagireddy, additional, Sreekumar, Arun, additional, Wenceslau, Camilla F, additional, Kumar, Matam Vijay, additional, Meyer, Katie A, additional, and Joe, Bina, additional

Published
2020
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16. Sex differences in salt‐responsive modulation of bile acids by microbiota regulates Hypertension

Author

Chakraborty, Saroj, primary, Lulla, Anju, additional, Cheng, Xi, additional, McCarthy, Cameron G., additional, Yeo, Ji-Youn, additional, Alimadadi, Ahmad, additional, Mandal, Juthika, additional, Saha, Piu, additional, Yeoh, Beng San, additional, Louis, Evangelina F, additional, Mell, Blair, additional, Jia, Wei, additional, Wenceslau, Camilla F., additional, Kumar, Matam Vijay, additional, and Meyer, Katie, additional

Published
2020
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17. Abstract P174: Adiposity Mediates the Association Between Gut Microbial Diversity and Hypertension: Cardia Study

Author

Yano, Yuichiro, primary, Lulla, Anju, additional, Howard, Annie Green, additional, Gidding, Samuel, additional, Muntner, Paul, additional, Lewis, Cora, additional, Blewer, Audrey L, additional, Hatano, Yu, additional, Lloyd-jones, Donald M, additional, Launer, Lenore J, additional, Bress, Adam, additional, and Meyer, Katie A, additional

Published
2020
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18. Microbial Community Composition and Antibiotic Resistance Genes within a North Carolina Urban Water System

Author

Lambirth, Kevin, primary, Tsilimigras, Matthew, additional, Lulla, Anju, additional, Johnson, James, additional, Al-Shaer, Abrar, additional, Wynblatt, Orion, additional, Sypolt, Shannon, additional, Brouwer, Cory, additional, Clinton, Sandra, additional, Keen, Olya, additional, Redmond, Molly, additional, Fodor, Anthony, additional, and Gibas, Cynthia, additional

Published
2018
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21. Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine.

Author

Lulla, Anju, Reznik, Sandra, Trombetta, Louis, and Billack, Blase

Subjects
NITROGEN mustards, LABORATORY rats, ALKYLATING agents, NITROGEN compounds, MECHLORETHAMINE, ARABIDOPSIS thaliana genetics, ORGANOSELENIUM compounds
Abstract

ABSTRACT Previous studies in this and other laboratories have demonstrated that ebselen (EB-1), an organoselenium compound, spares cells from mechlorethamine (HN2) toxicity in vitro. In the present study, the hypothesis that EB-1 will reduce dermal toxicity of HN2 in vivo is put forward and found to have merit. Using the mouse ear vesicant model (MEVM), HN2, applied topically, showed a dose-dependent effect upon ear swelling and thickness 24 h after treatment; whereas tissue injury consistent with vesication was observed at the higher test doses of HN2 (≥ 0.250 µmol per ear). To examine HN2 countermeasure activity using the MEVM, either hydrocortisone (HC), as a positive control, or EB-1, the test countermeasure, was administered as three topical treatments 15 min, 4 and 8 h after HN2 exposure. Using this approach, both HC and EB-1 were found to reduce tissue swelling associated with HN2 toxicity 24 h after exposure to the vesicant. Taken together, these data demonstrate for the first time the effectiveness of EB-1 as a vesicant countermeasure in a relevant in vivo model. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2014
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22. Choline metabolites and incident cardiovascular disease in a prospective cohort of adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

Shea, Jonathan W., Jacobs, David R., Howard, Annie Green, Lulla, Anju, Lloyd-Jones, Donald M., Murthy, Venkatesh L., Shah, Ravi V., Trujillo-Gonzalez, Isis, Gordon-Larsen, Penny, and Meyer, Katie A.

Abstract

The potential role for choline metabolite trimethylamine N-oxide (TMAO) in cardiovascular disease (CVD) has garnered much attention, but there have been limited data from diverse population-based cohorts. Furthermore, few studies have included circulating choline and betaine, which can serve as precursors to TMAO and may independently influence CVD.

Published
2023
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23. Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Author

Sprinkles JK, Lulla A, Hullings AG, Trujillo-Gonzalez I, Klatt KC, Jacobs DR Jr, Shah RV, Murthy VL, Howard AG, Gordon-Larsen P, and Meyer KA

Abstract

Objective: The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted in samples of older adults, often with a high prevalence of risk factors., Research Design and Methods: Participants were from year 15 of follow-up (2000-2001) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 3,133, aged 33-45 years) with plasma choline metabolite (choline, betaine, and trimethylamine N-oxide [TMAO]) data. We quantified associations between choline metabolites and 15-year risk of incident diabetes (n = 387) among participants free of diabetes at baseline using Cox proportional hazards regression models adjusted for sociodemographics, health behaviors, and clinical variables., Results: Betaine was inversely associated with 15-year risk of incident diabetes (hazard ratio 0.76 [95% CI 0.67, 0.88] per 1-SD unit betaine), and TMAO was positively associated with 15-year risk of incident diabetes (1.11 [1.01, 1.22] per 1-SD unit). Choline was not significantly associated with 15-year risk of incident diabetes (1.05 [0.94, 1.16] per 1-SD)., Conclusions: Our findings are consistent with other published literature supporting a role for choline metabolism in diabetes. Our study extends the current literature by analyzing a racially diverse population-based cohort of early middle-aged individuals in whom preventive activities may be most relevant., (© 2024 by the American Diabetes Association.)

Published
2024
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