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1. iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

Author

Park, Dong Shin, Kozaki, Tatsuya, Tiwari, Satish Kumar, Moreira, Marco, Khalilnezhad, Ahad, Torta, Federico, Olivié, Nicolas, Thiam, Chung Hwee, Liani, Oniko, Silvin, Aymeric, Phoo, Wint Wint, Gao, Liang, Triebl, Alexander, Tham, Wai Kin, Gonçalves, Leticia, Kong, Wan Ting, Raman, Sethi, Zhang, Xiao Meng, Dunsmore, Garett, Dutertre, Charles Antoine, Lee, Salanne, Ong, Jia Min, Balachander, Akhila, Khalilnezhad, Shabnam, Lum, Josephine, Duan, Kaibo, Lim, Ze Ming, Tan, Leonard, Low, Ivy, Utami, Kagistia Hana, Yeo, Xin Yi, Di Tommaso, Sylvaine, Dupuy, Jean-William, Varga, Balazs, Karadottir, Ragnhildur Thora, Madathummal, Mufeeda Changaramvally, Bonne, Isabelle, Malleret, Benoit, Binte, Zainab Yasin, Wei Da, Ngan, Tan, Yingrou, Wong, Wei Jie, Zhang, Jinqiu, Chen, Jinmiao, Sobota, Radoslaw M., Howland, Shanshan W., Ng, Lai Guan, Saltel, Frédéric, Castel, David, Grill, Jacques, Minard, Veronique, Albani, Salvatore, Chan, Jerry K. Y., Thion, Morgane Sonia, Jung, Sang Yong, Wenk, Markus R., Pouladi, Mahmoud A., Pasqualini, Claudia, Angeli, Veronique, Cexus, Olivier N. F., and Ginhoux, Florent

Published
2023
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3. Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

Author

del Rosario, Ricardo C. H., Poschmann, Jeremie, Lim, Carey, Cheng, Catherine Y., Kumar, Pavanish, Riou, Catherine, Ong, Seow Theng, Gerges, Sherif, Hajan, Hajira Shreen, Kumar, Dilip, Marzuki, Mardiana, Lu, Xiaohua, Lee, Andrea, Wijaya, Giovani Claresta, Rayan, Nirmala Arul, Zhuang, Zhong, Du Bruyn, Elsa, Chee, Cynthia Bin Eng, Lee, Bernett, Lum, Josephine, Zolezzi, Francesca, Poidinger, Michael, Rotzschke, Olaf, Khor, Chiea Chuen, Wilkinson, Robert J., Wang, Yee T., Chandy, George K, De Libero, Gennaro, Singhal, Amit, and Prabhakar, Shyam

Published
2022
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4. Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

Author

Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chan, Yi-Hao, Goh, Yun Shan, Amrun, Siti Naqiah, Ang, Nicholas, Rajapakse, Menaka Priyadharsani, Lum, Josephine, Foo, Shihui, Lee, Cheryl Yi-Pin, Carissimo, Guillaume, Chee, Rhonda Sin-Ling, Torres-Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Poh, Chek Meng, Young, Barnaby Edward, Tambyah, Paul A., Kalimuddin, Shirin, Leo, Yee-Sin, Lye, David C., Lee, Bernett, Biswas, Subhra, Howland, Shanshan Wu, Renia, Laurent, and Ng, Lisa F. P.

Published
2022
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6. Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

Author

del Rosario, Ricardo C. H., Poschmann, Jeremie, Lim, Carey, Cheng, Catherine Y., Kumar, Pavanish, Riou, Catherine, Ong, Seow Theng, Gerges, Sherif, Hajan, Hajira Shreen, Kumar, Dilip, Marzuki, Mardiana, Lu, Xiaohua, Lee, Andrea, Wijaya, Giovani Claresta, Rayan, Nirmala Arul, Zhuang, Zhong, Du Bruyn, Elsa, Chee, Cynthia Bin Eng, Lee, Bernett, Lum, Josephine, Zolezzi, Francesca, Poidinger, Michael, Rotzschke, Olaf, Khor, Chiea Chuen, Wilkinson, Robert J., Wang, Yee T., Chandy, George K, De Libero, Gennaro, Singhal, Amit, and Prabhakar, Shyam

Published
2022
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8. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses

Author

Chong, Shu Zhen, Evrard, Maximilien, Devi, Sapna, Chen, Jinmiao, Lim, Jyue Yuan, See, Peter, Zhang, Yiru, Adrover, José M, Lee, Bernett, Tan, Leonard, Li, Jackson LY, Liong, Ka Hang, Phua, Cindy, Balachander, Akhila, Boey, Adrian, Liebl, David, Tan, Suet Mien, Chan, Jerry KY, Balabanian, Karl, Harris, John E, Bianchini, Mariaelvy, Weber, Christian, Duchene, Johan, Lum, Josephine, Poidinger, Michael, Chen, Qingfeng, Rénia, Laurent, Wang, Cheng-I, Larbi, Anis, Randolph, Gwendalyn J, Weninger, Wolfgang, Looney, Mark R, Krummel, Matthew F, Biswas, Subhra K, Ginhoux, Florent, Hidalgo, Andrés, Bachelerie, Françoise, and Ng, Lai Guan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Good Health and Well Being, Animals, Antigens, Ly, Bone Marrow Cells, Cell Differentiation, Circadian Rhythm, Endotoxins, Female, Gene Expression Profiling, Lung, Mice, Inbred C57BL, Monocytes, Receptors, CXCR4, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

It is well established that Ly6Chi monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6Chi monocytes are not a homogenous population, as current data would suggest. Using computational analysis approaches to interpret multidimensional datasets, we demonstrate that BM Ly6Chi monocytes consist of two distinct subpopulations (CXCR4hi and CXCR4lo subpopulations) in both mice and humans. Transcriptome studies and in vivo assays revealed functional differences between the two subpopulations. Notably, the CXCR4hi subset proliferates and is immobilized in the BM for the replenishment of functionally mature CXCR4lo monocytes. We propose that the CXCR4hi subset represents a transitional premonocyte population, and that this sequential step of maturation from cMoPs serves to maintain a stable pool of BM monocytes. Additionally, reduced CXCR4 expression on monocytes, upon their exit into the circulation, does not reflect its diminished role in monocyte biology. Specifically, CXCR4 regulates monocyte peripheral cellular activities by governing their circadian oscillations and pulmonary margination, which contributes toward lung injury and sepsis mortality. Together, our study demonstrates the multifaceted role of CXCR4 in defining BM monocyte heterogeneity and in regulating their function in peripheral tissues.

Published
2016

9. Correction to: Robust Virus‐Specific Adaptive Immunity in COVID‐19 Patients with SARS‐CoV‐2 Δ382 Variant Infection

Author

Fong, Siew‐Wai, Yeo, Nicholas Kim‐Wah, Chan, Yi‐Hao, Goh, Yun Shan, Amrun, Siti Naqiah, Ang, Nicholas, Rajapakse, Menaka Priyadharsani, Lum, Josephine, Foo, Shihui, Lee, Cheryl Yi‐Pin, Carissimo, Guillaume, Chee, Rhonda Sin‐Ling, Torres‐Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Poh, Chek Meng, Young, Barnaby Edward, Tambyah, Paul A., Kalimuddin, Shirin, Leo, Yee‐Sin, Lye, David C., Lee, Bernett, Biswas, Subhra, Howland, Shanshan Wu, Renia, Laurent, and Ng, Lisa F. P.

Published
2022
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10. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL‐2, IL‐3, IL‐4, IL‐5, IL‐9, and IL‐13

Author

Lee, Wendy W. L., primary, Puan, Kia Joo, additional, Lee, Bernett, additional, Chua, Celine, additional, Koh, Ser Mei, additional, Yusof, Nurhashikin, additional, Tan, Kim Peng, additional, Luis, Boris San, additional, Ong, Jocelyn, additional, Merid, Simon Kebede, additional, Ang, Rachel, additional, Chan, Xue Ying, additional, Hui, Low Jing, additional, Terenzani, Elisa, additional, Lum, Josephine, additional, Foo, Shihui, additional, Zolezzi, Francesca, additional, Yan, Annabelle Tay Sok, additional, Melen, Erik, additional, Yi, Soh Jian, additional, Rotzschke, Olaf, additional, and Andiappan, Anand Kumar, additional

Published
2023
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12. Mapping the human DC lineage through the integration of high-dimensional techniques

Author

Dutertre, Charles-Antoine, See, Peter, Chen, Jinmiao, Günther, Patrick, McGovern, Naomi, Irac, Sergio Erdal, Gunawan, Merry, Beyer, Marc, Händler, Kristian, Duan, Kaibo, Sumatoh, Hermi Rizal Bin, Ruffin, Nicolas, Jouve, Mabel, Gea-Mallorquí, Ester, Hennekam, Raoul C. M., Lim, Tony, Yip, Chan Chung, Wen, Ming, Malleret, Benoit, Low, Ivy, Shadan, Nurhidaya Binte, Fen, Charlene Foong Shu, Tay, Alicia, Lum, Josephine, Zolezzi, Francesca, Larbi, Anis, Poidinger, Michael, Chan, Jerry K. Y., Chen, Qingfeng, Rénia, Laurent, Haniffa, Muzlifah, Benaroch, Philippe, Schlitzer, Andreas, Schultze, Joachim L., Newell, Evan W., and Ginhoux, Florent

Published
2017

13. Tropical urban environments reveal a strong association of CD45RB lo TH2A subset to allergic rhinitis

Author

Andiappan, Anand Kumar, primary, Lee, Wendy W.L., additional, PUAN, Kia Joo, additional, Lee, Bernett, additional, Chua, Celine, additional, Koh, Ser Mei, additional, YUSOF, Nurhashikin, additional, Tan, Kim Peng, additional, Luis, Boris San, additional, Ong, Jocelyn, additional, Merid, Simon, additional, Ang, Rachel, additional, Chan, Xue Ying, additional, Jing, Low, additional, Terenzani, Eliza, additional, Lum, Josephine, additional, Foo, Shihui, additional, Zolezzi, Francesca, additional, Yan, Annabelle Tay Sok, additional, Melén, Erik, additional, Yi, Soh Jian, additional, and Rotzschke, Olaf, additional

Published
2023
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14. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Author

Böhme, Julia, Martinez, Nuria, Li, Shamin, Lee, Andrea, Marzuki, Mardiana, Tizazu, Anteneh Mehari, Ackart, David, Frenkel, Jessica Haugen, Todd, Alexandra, Lachmandas, Ekta, Lum, Josephine, Shihui, Foo, Ng, Tze Pin, Lee, Bernett, Larbi, Anis, Netea, Mihai G., Basaraba, Randall, van Crevel, Reinout, Newell, Evan, Kornfeld, Hardy, and Singhal, Amit

Published
2020
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15. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Author

Kared, Hassen, Tan, Shu Wen, Lau, Mai Chan, Chevrier, Marion, Tan, Crystal, How, Wilson, Wong, Glenn, Strickland, Marie, Malleret, Benoit, Amoah, Amanda, Pilipow, Karolina, Zanon, Veronica, Govern, Naomi Mc, Lum, Josephine, Chen, Jin Miao, Lee, Bernett, Florian, Maria Carolina, Geiger, Hartmut, Ginhoux, Florent, Ruiz-Mateos, Ezequiel, Fulop, Tamas, Rajasuriar, Reena, Kamarulzaman, Adeeba, Ng, Tze Pin, Lugli, Enrico, and Larbi, Anis

Published
2020
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16. Doxycycline host-directed therapy in human pulmonary tuberculosis

Author

Miow, Qing Hao, Vallejo, Andres F., Wang, Yu, Hong, Jia Mei, Bai, Chen, Teo, Felicia S.W., Wang, Alvin D.Y., Loh, Hong Rong, Tan, Tuan Zea, Ding, Ying, She, Hoi Wah, Gan, Suay Hong, Paton, Nicholas I., Lum, Josephine, Tay, Alicia, Chee, Cynthia B.E., Tambyah, Paul A., Polak, Marta E., Wang, Yee Tang, Singhal, Amit, Elkington, Paul T., Friedland, Jon S., and Ong, Catherine W.M.

Subjects
Pulmonary tuberculosis -- Drug therapy, Doxycycline -- Testing, Host-bacteria relationships -- Health aspects, Molecular targeted therapy -- Testing, Health care industry
Abstract

BACKGROUND. Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial investigating doxycycline, a licensed broad-spectrum MMP inhibitor, in patients with pulmonary TB. METHODS. Thirty patients with pulmonary TB were enrolled within 7 days of initiating anti-TB treatment and randomly assigned to receive either 100 mg doxycycline or placebo twice a day for 14 days, in addition to standard care. RESULTS. Whole blood RNA-sequencing demonstrated that doxycycline accelerated restoration of dysregulated gene expression in TB towards normality, rapidly down-regulating type I and II interferon and innate immune response genes, and up-regulating B-cell modules relative to placebo. The effects persisted for 6 weeks after doxycycline discontinuation, concurrent with suppressed plasma MMP- 1. Doxycycline significantly reduced sputum MMP-1, -8, -9, -12 and -13, suppressed type I collagen and elastin destruction, reduced pulmonary cavity volume without altering sputum mycobacterial loads, and was safe. CONCLUSION. Adjunctive doxycycline with standard anti-TB treatment suppressed pathological MMPs in PTB patients. Larger studies on adjunctive doxycycline to limit TB immunopathology are merited. TRIAL REGISTRATION. ClinicalTrials.gov NCT02774993. FUNDING. Singapore National Medical Research Council (NMRC/CNIG/1120/2014, NMRC/Seedfunding/0010/2014, NMRC/ CISSP/2015/009a); the Singapore Infectious Diseases Initiative (SIDI/2013/013); National University Health System (PFFR-28 January 14, NUHSRO/2014/039/BSL3- SeedFunding/Jul/01); the Singapore Immunology Network Immunomonitoring platform (BMRC/IAF/311006, H16/99/b0/011, NRF2017_SISFP09); an ExxonMobil Research Fellowship, NUHS Clinician Scientist Program (NMRC/TA/0042/2015, CSAINV17nov014); the UK Medical Research Council (MR/P023754/1, MR/N006631/1); a NUS Postdoctoral Fellowship (NUHSRU/2017/073/PDF/03); The Royal Society Challenge Grant (CHG\R1\170084); the Sir Henry Dale Fellowship, Wellcome Trust (109377/Z/15/Z); and A*STAR., Introduction Globally, an estimated 10 million people develop tuberculosis (TB) each year, and this disease remains a leading cause of death from a single infectious agent (1). Standard short-course anti-TB [...]

Published
2021
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19. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL‐2, IL‐3, IL‐4, IL‐5, IL‐9, and IL‐13.

Author

Lee, Wendy W. L., Puan, Kia Joo, Lee, Bernett, Chua, Celine, Koh, Ser Mei, Yusof, Nurhashikin, Tan, Kim Peng, Luis, Boris San, Ong, Jocelyn, Merid, Simon Kebede, Ang, Rachel, Chan, Xue Ying, Hui, Low Jing, Terenzani, Elisa, Lum, Josephine, Foo, Shihui, Zolezzi, Francesca, Yan, Annabelle Tay Sok, Melen, Erik, and Yi, Soh Jian

Subjects
TH2 cells, ALLERGIC rhinitis, ATOPY
Abstract

Allergic airway diseases such as allergic rhinitis (AR) affects more than 400 million individuals worldwide and afflicts substantial health and economic morbidity.[1] AR is strongly associated with a Type 2 response, characterized by the cytokines IL-5, IL-4, and IL-13. Thus, the severity of eosinophilic airway allergies such as AR seems to be driven by an activated terminally differentiated CD161 SP + sp Th2 subset that is able to secrete a complex set of inflammatory cytokines. Eosinophilic allergic rhinitis is strongly associated with the CD45RBlo subset of CD161+ Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13 Scatterplots showing (D) proportion of CD161+ Th2 and (E) CD45RB expression on CD161+ Th2 comparison between non-AR and AR individuals. [Extracted from the article]

Published
2023
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20. Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology

Author

Kvedaraite, Egle, primary, Milne, Paul, additional, Khalilnezhad, Ahad, additional, Chevrier, Marion, additional, Sethi, Raman, additional, Lee, Hong Kai, additional, Hagey, Daniel W., additional, von Bahr Greenwood, Tatiana, additional, Mouratidou, Natalia, additional, Jädersten, Martin, additional, Lee, Nicole Yee Shin, additional, Minnerup, Lara, additional, Tan, Yingrou, additional, Dutertre, Charles-Antoine, additional, Benac, Nathan, additional, Hwang, You Yi, additional, Lum, Josephine, additional, Loh, Amos Hong Pheng, additional, Jansson, Jessica, additional, Teng, Karen Wei Weng, additional, Khalilnezhad, Shabnam, additional, Xu, Weili, additional, Resteu, Anastasia, additional, Tey, Hong Liang, additional, Guan, Ng Lai, additional, Larbi, Anis, additional, Howland, Shanshan Wu, additional, Arnell, Henrik, additional, Andaloussi, Samir E. L., additional, Braier, Jorge, additional, Rassidakis, Georgios, additional, Galluzzo, Laura, additional, Dzionek, Andrzej, additional, Henter, Jan-Inge, additional, Chen, Jinmiao, additional, Collin, Matthew, additional, and Ginhoux, Florent, additional

Published
2022
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21. Systematic characterization of basophil anergy

Author

Puan, Kia Joo, Andiappan, Anand Kumar, Lee, Bernett, Kumar, Dilip, Lai, Tuck Siong, Yeo, Giminna, Bercin, Derya, Starke, Mireille, Haase, Doreen, Lum, Josephine, Chew, Fook Tim, Connolly, John, Wong, Siew Cheng, Zolezzi, Francesca, Poidinger, Michael, Wang, De Yun, and Rötzschke, Olaf

Published
2017
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22. Transcriptomics of rhinovirus persistence reveals sustained expression of RIG‐I and interferon‐stimulated genes in nasal epithelial cells in vitro

Author

Ong, Hsiao Hui, primary, Andiappan, Anand Kumar, additional, Duan, Kaibo, additional, Lum, Josephine, additional, Liu, Jing, additional, Tan, Kai Sen, additional, Howland, Shanshan, additional, Lee, Bernett, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Chow, Vincent T., additional, and Wang, De‐Yun, additional

Published
2022
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23. Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize NSAID-exacerbated respiratory disease

Author

Andiappan, Anand Kumar, Asad, Mohammad, Chua, Celine, Sehanobish, Esha, Ren, Zhen, Chan, Xue Ying, Lum, Josephine, Ang, Nicholas, Duan, Kaibo, Gersten, Adam, Abuzeid, Waleed M., Akbar, Nadeem, Gibber, Marc, Howland, Shanshan, Lee, Bernett, Rotzschke, Olaf, Porcelli, Steven A., and Jerschow, Elina

Subjects
Inflammation, Nasal Mucosa, Nasal Polyps, Chronic Disease, Anti-Inflammatory Agents, Humans, Sinusitis, Article, Rhinitis
Published
2021

24. Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non‐steroidal anti‐inflammatory drug exacerbated respiratory disease

Author

Andiappan, Anand Kumar, primary, Asad, Mohammad, additional, Chua, Celine, additional, Sehanobish, Esha, additional, Ren, Zhen, additional, Chan, Xue Ying, additional, Lum, Josephine, additional, Ang, Nicholas, additional, Duan, Kaibo, additional, Gersten, Adam, additional, Abuzeid, Waleed M., additional, Akbar, Nadeem, additional, Gibber, Marc, additional, Howland, Shanshan, additional, Lee, Bernett, additional, Rotzschke, Olaf, additional, Porcelli, Steven A., additional, and Jerschow, Elina, additional

Published
2021
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25. Correction to: Robust Virus‐Specific Adaptive Immunity in COVID‐19 Patients with SARS‐CoV‐2 Δ382 Variant Infection

Author

Fong, Siew‐Wai, primary, Yeo, Nicholas Kim‐Wah, additional, Chan, Yi‐Hao, additional, Goh, Yun Shan, additional, Amrun, Siti Naqiah, additional, Ang, Nicholas, additional, Rajapakse, Menaka Priyadharsani, additional, Lum, Josephine, additional, Foo, Shihui, additional, Lee, Cheryl Yi‐Pin, additional, Carissimo, Guillaume, additional, Chee, Rhonda Sin‐Ling, additional, Torres‐Ruesta, Anthony, additional, Tay, Matthew Zirui, additional, Chang, Zi Wei, additional, Poh, Chek Meng, additional, Young, Barnaby Edward, additional, Tambyah, Paul A., additional, Kalimuddin, Shirin, additional, Leo, Yee‐Sin, additional, Lye, David C., additional, Lee, Bernett, additional, Biswas, Subhra, additional, Howland, Shanshan Wu, additional, Renia, Laurent, additional, and Ng, Lisa F. P., additional

Published
2021
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26. Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

Author

Fong, Siew-Wai, primary, Yeo, Nicholas Kim-Wah, additional, Chan, Yi-Hao, additional, Goh, Yun Shan, additional, Amrun, Siti Naqiah, additional, Ang, Nicholas, additional, Rajapakse, Menaka Priyadharsani, additional, Lum, Josephine, additional, Foo, Shihui, additional, Lee, Cheryl Yi-Pin, additional, Carissimo, Guillaume, additional, Chee, Rhonda Sin-Ling, additional, Torres-Ruesta, Anthony, additional, Tay, Matthew Zirui, additional, Chang, Zi Wei, additional, Poh, Chek Meng, additional, Young, Barnaby Edward, additional, Tambyah, Paul A., additional, Kalimuddin, Shirin, additional, Leo, Yee-Sin, additional, Lye, David C., additional, Lee, Bernett, additional, Biswas, Subhra, additional, Howland, Shanshan Wu, additional, Renia, Laurent, additional, and Ng, Lisa F. P., additional

Published
2021
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27. Disrupted epithelial barrier in nasal polyps characterizes aspirin exacerbated respiratory disease

Author

Andiappan, Anand Kumar, primary, Asad, Mohammad, additional, Chua, Celine, additional, Sehanobish, Esha, additional, Ren, Zhen, additional, Chan, Xue Ying, additional, Lum, Josephine, additional, Ang, Nicholas, additional, Duan, Kaibo, additional, Gersten, Adam, additional, Abuzeid, Waleed M., additional, Akbar, Nadeem, additional, Gibber, Marc, additional, Howland, Shanshan, additional, Lee, Bernett, additional, Rotzschke, Olaf, additional, Porcelli, Steven A., additional, and Jerschow, Elina, additional

Published
2021
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28. A subset of Kupffer cells regulates metabolism through the expression of CD36

Author

Blériot, Camille, primary, Barreby, Emelie, additional, Dunsmore, Garett, additional, Ballaire, Raphaelle, additional, Chakarov, Svetoslav, additional, Ficht, Xenia, additional, De Simone, Giorgia, additional, Andreata, Francesco, additional, Fumagalli, Valeria, additional, Guo, Wei, additional, Wan, Guochen, additional, Gessain, Gregoire, additional, Khalilnezhad, Ahad, additional, Zhang, Xiao Meng, additional, Ang, Nicholas, additional, Chen, Ping, additional, Morgantini, Cecilia, additional, Azzimato, Valerio, additional, Kong, Wan Ting, additional, Liu, Zhaoyuan, additional, Pai, Rhea, additional, Lum, Josephine, additional, Shihui, Foo, additional, Low, Ivy, additional, Xu, Connie, additional, Malleret, Benoit, additional, Kairi, Muhammad Faris Mohd, additional, Balachander, Akhila, additional, Cexus, Olivier, additional, Larbi, Anis, additional, Lee, Bernett, additional, Newell, Evan W., additional, Ng, Lai Guan, additional, Phoo, Wint Wint, additional, Sobota, Radoslaw M., additional, Sharma, Ankur, additional, Howland, Shanshan W., additional, Chen, Jinmiao, additional, Bajenoff, Marc, additional, Yvan-Charvet, Laurent, additional, Venteclef, Nicolas, additional, Iannacone, Matteo, additional, Aouadi, Myriam, additional, and Ginhoux, Florent, additional

Published
2021
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29. High-fat diet induces a predisposition to follicular hyperkeratosis and neutrophilic folliculitis in mice

Author

Nakamizo, Satoshi, primary, Honda, Tetsuya, additional, Sato, Tomohito, additional, Al Mamun, Md., additional, Chow, Zachary, additional, Duan, Kaibo, additional, Lum, Josephine, additional, Tan, Kahbing Jasmine, additional, Tomari, Kaori, additional, Sato, Reiko, additional, Kitoh, Akihiko, additional, Tay, Angeline S.L., additional, Common, John E.A., additional, Guan, Ng Lai, additional, Setou, Mitsutoshi, additional, Ginhoux, Florent, additional, and Kabashima, Kenji, additional

Published
2021
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31. C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Author

Hoeffel, Guillaume, Chen, Jinmiao, Lavin, Yonit, Low, Donovan, Almeida, Francisca F., See, Peter, Beaudin, Anna E., Lum, Josephine, Low, Ivy, Forsberg, Camilla E., Poidinger, Michael, Zolezzi, Francesca, Larbi, Anis, Ng, Lai Guan, Chan, Jerry K.Y., Greter, Melanie, Becher, Burkhard, Samokhvalov, Igor M., Merad, Miriam, and Ginhoux, Florent

Published
2015
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33. Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Author

Nakamizo, Satoshi, primary, Dutertre, Charles-Antoine, additional, Khalilnezhad, Ahad, additional, Zhang, Xiao Meng, additional, Lim, Shawn, additional, Lum, Josephine, additional, Koh, Geraldine, additional, Foong, Charlene, additional, Yong, Pearly Jean Ai, additional, Tan, Kahbing Jasmine, additional, Sato, Reiko, additional, Tomari, Kaori, additional, Yvan-Charvet, Laurent, additional, He, Helen, additional, Guttman-Yassky, Emma, additional, Malleret, Benoit, additional, Shibuya, Rintaro, additional, Iwata, Masashi, additional, Janela, Baptiste, additional, Goto, Tsuyoshi, additional, Lucinda, Tan Siyun, additional, Tang, Mark B.Y., additional, Theng, Colin, additional, Julia, Valerie, additional, Hacini-Rachinel, Feriel, additional, Kabashima, Kenji, additional, and Ginhoux, Florent, additional

Published
2021
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34. Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells

Author

Andiappan, Anand Kumar, primary, Puan, Kia Joo, additional, Lee, Bernett, additional, Yeow, Poh Tuang, additional, Yusof, Nurhashikin, additional, Merid, Simon Kebede, additional, Kumar, Dilip, additional, Lum, Josephine, additional, Foo, Shihui, additional, Koh, Geraldine, additional, Poidinger, Michael, additional, Zolezzi, Francesca, additional, Wang, De Yun, additional, Melén, Erik, additional, and Rotzschke, Olaf, additional

Published
2021
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35. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Author

McGovern, Naomi, Shin, Amanda, Low, Gillian, Low, Donovan, Duan, Kaibo, Yao, Leong Jing, Msallam, Rasha, Low, Ivy, Shadan, Nurhidaya Binte, Sumatoh, Hermi R, Soon, Erin, Lum, Josephine, Mok, Esther, Hubert, Sandra, See, Peter, Kunxiang, Edwin Huang, Lee, Yie Hou, Janela, Baptiste, Choolani, Mahesh, Mattar, Citra Nurfarah Zaini, Fan, Yiping, Lim, Tony Kiat Hon, Chan, Dedrick Kok Hong, Tan, Ker-Kan, Tam, John Kit Chung, Schuster, Christopher, Elbe-Brger, Adelheid, Wang, Xiao-nong, Bigley, Venetia, Collin, Matthew, Haniffa, Muzlifah, Schlitzer, Andreas, Poidinger, Michael, Albani, Salvatore, Larbi, Anis, Newell, Evan W, Chan, Jerry Kok Yen, and Ginhoux, Florent

Subjects
Dendritic cells -- Physiological aspects, Immune response -- Observations, T cells -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Naomi McGovern [1]; Amanda Shin [1, 2]; Gillian Low [1]; Donovan Low [1]; Kaibo Duan [1]; Leong Jing Yao [3]; Rasha Msallam [1]; Ivy Low [1]; Nurhidaya Binte Shadan [...]

Published
2017
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37. Single cell RNA-seq reveals immunosuppressive gastric stem-like cancer cells as a poor prognostic factor

Author

Lee, Hong Kai, primary, Ang, Kok Siong, additional, Chevrier, Marion, additional, Goh, Michelle, additional, Ling, Jingjing, additional, Koh, Vivien, additional, Zhang, Xiaomeng, additional, Tan, Jia Chi, additional, Lee, Nicole, additional, Erdal Irac, Sergio, additional, Lim, Ze Ming, additional, Lum, Josephine, additional, Tay, Alicia, additional, Antoine Dutertre, Charles, additional, Tang, Carolyn, additional, Wong, Calista, additional, Lau, Mai Chan, additional, Lim, Chun Jye, additional, Chuah, Samuel Wen Jin, additional, Lim, Sherlly, additional, Yeong, Joe Poh Sheng, additional, Chew, Valerie, additional, Larbi, Anis, additional, Singhal, Amit, additional, Poidinger, Michael, additional, Ng, Matthew Chau Hsien, additional, Wu Howland, Shanshan, additional, Tan, Patrick, additional, Ginhoux, Florent, additional, So, Jimmy, additional, Yong, Wei Peng, additional, and Chen, Jinmiao, additional

Published
2020
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38. Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

Author

Chaudhary, Deepika, primary, Marzuki, Mardiana, additional, Lee, Andrea, additional, Bouzeyen, Rania, additional, Singh, Avantika, additional, Gosain, Tannu Priya, additional, Kidwai, Saqib, additional, Grady, Courtney, additional, Tsotetsi, Kholiswa, additional, Chawla, Kiran, additional, Shihui, Foo, additional, Lum, Josephine, additional, Gupta, Sonu Kumar, additional, Agarwal, Nisheeth, additional, Tsenova, Liana, additional, Kumar, Yashwant, additional, Lee, Bernett, additional, Kumar, Pradeep, additional, Thakur, Krishan Gopal, additional, Singh, Ramandeep, additional, and Singhal, Amit, additional

Published
2020
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39. Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells

Author

Böhme, Julia, primary, Martinez, Nuria, additional, Li, Shamin, additional, Lee, Andrea, additional, Marzuki, Mardiana, additional, Tizazu, Anteneh Mehari, additional, Ackart, David, additional, Frenkel, Jessica Haugen, additional, Todd, Alexandra, additional, Lachmandas, Ekta, additional, Lum, Josephine, additional, Shihui, Foo, additional, Ng, Tze Pin, additional, Lee, Bernett, additional, Larbi, Anis, additional, Netea, Mihai G, additional, Basaraba, Randall, additional, van Crevel, Reinout, additional, Newell, Evan, additional, Kornfeld, Hardy, additional, and Singhal, Amit, additional

Published
2020
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40. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

Author

Takata, Kazuyuki, primary, Kozaki, Tatsuya, additional, Lee, Christopher Zhe Wei, additional, Thion, Morgane Sonia, additional, Otsuka, Masayuki, additional, Lim, Shawn, additional, Utami, Kagistia Hana, additional, Fidan, Kerem, additional, Park, Dong Shin, additional, Malleret, Benoit, additional, Chakarov, Svetoslav, additional, See, Peter, additional, Low, Donovan, additional, Low, Gillian, additional, Garcia-Miralles, Marta, additional, Zeng, Ruizhu, additional, Zhang, Jinqiu, additional, Goh, Chi Ching, additional, Gul, Ahmet, additional, Hubert, Sandra, additional, Lee, Bernett, additional, Chen, Jinmiao, additional, Low, Ivy, additional, Shadan, Nurhidaya Binte, additional, Lum, Josephine, additional, Wei, Tay Seok, additional, Mok, Esther, additional, Kawanishi, Shohei, additional, Kitamura, Yoshihisa, additional, Larbi, Anis, additional, Poidinger, Michael, additional, Renia, Laurent, additional, Ng, Lai Guan, additional, Wolf, Yochai, additional, Jung, Steffen, additional, Önder, Tamer, additional, Newell, Evan, additional, Huber, Tara, additional, Ashihara, Eishi, additional, Garel, Sonia, additional, Pouladi, Mahmoud A., additional, and Ginhoux, Florent, additional

Published
2020
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41. CD27 hiCD38 hi Plasmablasts are Activated B Cells of Mixed Origin with Distinct Function

Author

Rouers, Angeline, primary, Appanna, Ramapraba, additional, Chevrier, Marion, additional, Lum, Josephine, additional, Lau, MaiChan, additional, Tan, Lingqiao, additional, Tay, Alicia, additional, Sathiakumar, Durgalakshmi, additional, Kaur, Kaval, additional, Boehme, Julia, additional, Leo, Yee-Sin, additional, Howland, Shanshan W., additional, Singhal, Amit, additional, Chen, Jinmiao, additional, and Fink, Katja, additional

Published
2020
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42. Immune Landscape of 382-Nt Deleted SARS-CoV-2 Reveals Heightened Adaptive Response Indicating Prophylactic Potential Against COVID-19

Author

Fong, Siew-Wai, primary, Yeo, Nicholas Kim-Wah, additional, Chan, Yi-Hao, additional, Goh, Yun Shan, additional, Amrun, Siti Naqiah, additional, Ang, Nicholas, additional, Lum, Josephine, additional, Shihui, Foo, additional, Lee, Cheryl Yi-Pin, additional, Carissimo, Guillaume, additional, Chee, Rhonda Sin-Ling, additional, Torres-Ruesta, Anthony, additional, Tay, Matthew Zirui, additional, Chang, Zi Wei, additional, Poh, Chek Meng, additional, Young, Barnaby E., additional, Tambyah, Paul A., additional, Kalimuddin, Shirin, additional, Leo, Yee-Sin, additional, Lye, David Chien, additional, Lee, Bernett, additional, Biswas, Subhra, additional, Howland, Shanshan W., additional, Renia, Laurent, additional, and Ng, Lisa F.P., additional

Published
2020
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44. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

45. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

46. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Author

Thion, Morgane Sonia, Low, Donovan, Silvin, Aymeric, Chen, Jinmiao, Grisel, Pauline, Schulte-Schrepping, Jonas, Blecher, Ronnie, Ulas, Thomas, Squarzoni, Paola, Hoeffel, Guillaume, Coulpier, Fanny, Siopi, Eleni, David, Friederike Sophie, Scholz, Claus, Shihui, Foo, Lum, Josephine, Amoyo, Arlaine Anne, Larbi, Anis, Poidinger, Michael, Buttgereit, Anne, Lledo, Pierre-Marie, Greter, Melanie, Chan, Jerry Kok Yen, Amit, Ido, Beyer, Marc, Schultze, Joachim Ludwig, Schlitzer, Andreas, Pettersson, Sven, Ginhoux, Florent, Garel, Sonia, Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Bonn = University of Bonn, Weizmann Institute of Science [Rehovot, Israël], Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Perception et Mémoire / Perception and Memory, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), National Cancer Centre Singapore, Universität Zürich [Zürich] = University of Zurich (UZH), KK Women's and Children's Hospital [Singapore], Karolinska Institute, This work was supported by grants from the LKC School of Medicine, SCELSE, MOE (Tier1 grant), NIMBLE grant NTU, NTU GUTME grant, Swedish Medical Council (VR to S.P.), the DFG (SFB704 to J.L.S., M.B., and T.U. and SCHL 2116/1-1 to A.S.), the Federal Ministry for Economic Affairs and Energy (BMWi Project FASTGENOMICS to J.L.S.), the European Union’s Horizon 2020 (733100-SYSCID to M.B., J.S.S., and J.L.S.), INSERM, CNRS, the ERC Consolidator (NImO 616080 to S.G.), and from the Merlion Program (to S.G and F.G.). M.B., A.S., and J.L.S. are members of the Excellence Cluster ImmunoSensation. F.G. and S.G. are EMBO YIP awardees., Lee Kong Chian School of Medicine (LKCMedicine), School of Biological Sciences, Agency for science, technology and research [Singapore] (A*STAR), GenomiqueENS (Genomique ENS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, National Cancer Centre Singapore (NCCS), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Nanyang Technological University [Singapour], Karolinska Institutet [Stockholm], European Project: 616080,EC:FP7:ERC,ERC-2013-CoG,NIMO(2014), DUMENIL, Anita, Neural and Immune Orchestrators of Forebrain Wiring - NIMO - - EC:FP7:ERC2014-09-01 - 2019-08-31 - 616080 - VALID, University of Bonn, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), THION, Morgane Sonia, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
Male, prenatal, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV]Life Sciences [q-bio], microbiology [Prenatal Exposure Delayed Effects], microbiome, metabolism [Microglia], [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Article, antibiotics, neuroinflammation, Mice, Sex Factors, embryology [Brain], Antibiotics, Pregnancy, [SDV.BDD] Life Sciences [q-bio]/Development Biology, cytology [Microglia], sex, Animals, Germ-Free Life, Humans, ddc:610, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS, Cells, Cultured, CXCR4, cytology [Brain], Macrophages, neurodevelopmental disorders, Microbiota, Brain, Cell Differentiation, Chromatin Assembly and Disassembly, Mice, Inbred C57BL, metabolism [Brain], germ-free, Prenatal Exposure Delayed Effects, [SDV.IMM]Life Sciences [q-bio]/Immunology, embryogenesis, Female, Microglia, Transcriptome
Abstract

Summary Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion. Finally, human fetal microglia exhibited significant overlap with the murine transcriptomic signature. Our study shows that microglia respond to environmental challenges in a sex- and time-dependent manner from prenatal stages, with major implications for our understanding of microglial contributions to health and disease., Graphical Abstract, Highlights • Microglia undergo sequential phases of differentiation during development • The maternal microbiome influences microglial properties during prenatal stages • The absence of the microbiome has a sex- and time-specific impact on microglia • Microbiome depletions have acute and long-term effects on microglial properties, Microglia respond to environmental challenges, such as signals from the gut microbiome, in a sex- and time-dependent manner.

Published
2018

47. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles-Antoine, primary, Becht, Etienne, additional, Irac, Sergio Erdal, additional, Khalilnezhad, Ahad, additional, Narang, Vipin, additional, Khalilnezhad, Shabnam, additional, Ng, Pei Y., additional, van den Hoogen, Lucas L., additional, Leong, Jing Yao, additional, Lee, Bernett, additional, Chevrier, Marion, additional, Zhang, Xiao Meng, additional, Yong, Pearly Jean Ai, additional, Koh, Geraldine, additional, Lum, Josephine, additional, Howland, Shanshan Wu, additional, Mok, Esther, additional, Chen, Jinmiao, additional, Larbi, Anis, additional, Tan, Henry Kun Kiaang, additional, Lim, Tony Kiat Hon, additional, Karagianni, Panagiota, additional, Tzioufas, Athanasios G., additional, Malleret, Benoit, additional, Brody, Joshua, additional, Albani, Salvatore, additional, van Roon, Joel, additional, Radstake, Timothy, additional, Newell, Evan W., additional, and Ginhoux, Florent, additional

Published
2019
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48. RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications

Author

Tan, Kai Sen, primary, Andiappan, Anand Kumar, additional, Lee, Bernett, additional, Yan, Yan, additional, Liu, Jing, additional, Tang, See Aik, additional, Lum, Josephine, additional, He, Ting Ting, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Lim, Hui Fang, additional, Choi, Hyung Won, additional, Rotzschke, Olaf, additional, Chow, Vincent T, additional, and Wang, De Yun, additional

Published
2019
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49. Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps

Author

Peng, Yang, primary, Zi, Xiao-Xue, additional, Tian, Teng-Fei, additional, Lee, Bernett, additional, Lum, Josephine, additional, Tang, See Aik, additional, Tan, Kai Sen, additional, Qiu, Qian-Hui, additional, Ye, Jing, additional, Shi, Li, additional, Guan, Wei-Jie, additional, Andiappan, Anand Kumar, additional, and Wang, De Yun, additional

Published
2019
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