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3. Predictive modeling toward refinement of behavior-based pain assessment in horses

Author

Trindade, Pedro Henrique Esteves, Barreto da Rocha, Paula, Driessen, Bernd, McDonnell, Sue M., Hopster, Klaus, Zarucco, Laura, Gozalo-Marcilla, Miguel, Hopster-Iversen, Charlotte, Rocha, Thamiris Kristine Gonzaga da, Taffarel, Marilda Onghero, Alonso, Bruna Bodini, Schauvliege, Stijn, Mello, João Fernando Serrajordia Rocha de, and Luna, Stelio Pacca Loureiro

Published
2023
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7. Development and Validation of the Unesp-Botucatu Goat Acute Pain Scale

Author

Fonseca, Mariana Werneck, primary, Trindade, Pedro Henrique Esteves, additional, Pinho, Renata Haddad, additional, Justo, André Augusto, additional, Tomacheuski, Rubia Mitalli, additional, Silva, Nuno Emanuel de Oliveira Figueiredo da, additional, Gonçalves, Heraldo Cesar, additional, and Luna, Stelio Pacca Loureiro, additional

Published
2023
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8. Automated Pain Recognition in Rabbits

Author

Feighelstein, Marcelo, primary, Ehrlich, Yamit, additional, Naftaly, Li, additional, Alpin, Miriam, additional, Nadir, Shenhav, additional, Shimshoni, Ilan, additional, Pinho, Renata Haddad, additional, Luna, Stelio Pacca Loureiro, additional, and Zamansky, Anna, additional

Published
2023
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15. Comparison of morphine, ketoprofen and Arnica montana 6x and 30x per oral transmucosal or subcutaneous route for control of postoperative pain in cats subjected to hysterectomy with bilateral salpingo-oophorectomy/Comparacao de morfina, cetoprofeno e Arnica montana 6x e 30x por via transmucosa oral ou subcutanea para control e de dor pos-operatoria em gatas submetidas a histerectomia e ooforectomia bilateral

Author

de Fatima Rodrigues, Denise, Luna, Stelio Pacca Loureiro, Brondani, Juliana Tabarelli, and Minto, Bruno Watanabe

Published
2016
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17. Validation of the rabbit pain behaviour scale (RPBS) to assess acute postoperative pain in rabbits (Oryctolagus cuniculus)

Author

Haddad Pinho, Renata, primary, Luna, Stelio Pacca Loureiro, additional, Esteves Trindade, Pedro Henrique, additional, Augusto Justo, André, additional, Santilli Cima, Daniela, additional, Werneck Fonseca, Mariana, additional, Watanabe Minto, Bruno, additional, Del Lama Rocha, Fabiana, additional, Miller, Amy, additional, Flecknell, Paul, additional, and Leach, Matthew C., additional

Published
2022
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22. A critical evaluation for validation of composite and unidimensional postoperative pain scales in horses

Author

Barreto da Rocha, Paula, primary, Driessen, Bernd, additional, McDonnell, Sue M., additional, Hopster, Klaus, additional, Zarucco, Laura, additional, Gozalo-Marcilla, Miguel, additional, Hopster-Iversen, Charlotte, additional, Esteves Trindade, Pedro Henrique, additional, Gonzaga da Rocha, Thamiris Kristine, additional, Taffarel, Marilda Onghero, additional, Alonso, Bruna Bodini, additional, Schauvliege, Stijn, additional, and Luna, Stelio Pacca Loureiro, additional

Published
2021
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23. A critical evaluation for validation of composite and unidimensional postoperative pain scales in horses

Author

da Rocha, Paula Barreto, Driessen, Bernd, McDonnell, Sue M., Hopster, Klaus, Zarucco, Laura, Gozalo-Marcilla, Miguel, Hopster-Iversen, Charlotte, Trindade, Pedro Henrique Esteves, da Rocha, Thamiris Kristine Gonzaga, Taffarel, Marilda Onghero, Alonso, Bruna Bodini, Schauvliege, Stijn, Luna, Stelio Pacca Loureiro, da Rocha, Paula Barreto, Driessen, Bernd, McDonnell, Sue M., Hopster, Klaus, Zarucco, Laura, Gozalo-Marcilla, Miguel, Hopster-Iversen, Charlotte, Trindade, Pedro Henrique Esteves, da Rocha, Thamiris Kristine Gonzaga, Taffarel, Marilda Onghero, Alonso, Bruna Bodini, Schauvliege, Stijn, and Luna, Stelio Pacca Loureiro

Abstract

Proper pain therapy requires adequate pain assessment. This study evaluated the reliability and validity of the Unesp-Botucatu horse acute pain scale (UHAPS), the Orthopedic Composite Pain Scale (CPS) and unidimensional scales in horses admitted for orthopedic and soft tissue surgery. Forty-two horses were assessed and videotaped before surgery, up to 4 hours postoperatively, up to 3 hours after analgesic treatment, and 24 hours postoperatively (168 video clips). After six evaluators viewing each edited video clip twice in random order at a 20-day interval, they chose whether analgesia would be indicated and applied the Simple Descriptive, Numeric and Visual Analog scales, CPS, and UHAPS. For all evaluators, intraobserver reliability of UHAPS and CPS ranged from 0.70 to 0.97. Reproducibility was variable among the evaluators and ranged from poor to very good for all scales. Principal component analysis showed a weak association among 50% and 62% of the UHAPS and CPS items, respectively. Criterion validity based on Spearman correlation among all scales was above 0.67. Internal consistency was minimally acceptable (0.51-0.64). Item-total correlation was acceptable (0.3-0.7) for 50% and 38% of UHAPS and CPS items, respectively. UHAPS and CPS were specific (90% and 79% respectively), but both were not sensitive (43 and 38%, respectively). Construct validity (responsiveness) was confirmed for all scales because pain scores increased after surgery. The cut-off point for rescue analgesia was ≥ 5 and ≥ 7 for the UHAPS and CPS, respectively. All scales presented adequate repeatability, criterion validity, and partial responsiveness. Both composite scales showed poor association among items, minimally acceptable internal consistency, and weak sensitivity, indicating that they are suboptimal instruments for assessing postoperative pain. Both composite scales require further refinement with the exclusion of redundant or needless items and reduction of their maximum score app

Published
2021

33. Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells

Author

OKAMOTO-OKUBO, Celina Emiko, primary, CASSU, Renata Navarro, additional, JOAQUIM, Jean Guilherme Fernandes, additional, REIS MESQUITA, Luciane dos, additional, RAHAL, Sheila Canevese, additional, OLIVEIRA, Hugo S Salvador, additional, TAKAHIRA, Regina, additional, ARRUDA, Isadora, additional, MAIA, Leandro, additional, CRUZ LANDIM, Fernanda da, additional, and LUNA, Stelio Pacca Loureiro, additional

Published
2021
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39. Validation of the UNESP-Botucatu pig composite acute pain scale (UPAPS)

Author

Luna, Stelio Pacca Loureiro, primary, de Araújo, Ana Lucélia, additional, da Nóbrega Neto, Pedro Isidro, additional, Brondani, Juliana Tabarelli, additional, de Oliveira, Flávia Augusta, additional, Azerêdo, Liliane Marinho dos Santos, additional, Telles, Felipe Garcia, additional, and Trindade, Pedro Henrique Esteves, additional

Published
2020
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40. AVALIAÇÃO DO EFEITO DA ACUPUNTURA E TÉCNICAS AFINS E PERFIL CLÍNICO E EPIDEMIOLÓGICO DE CÃES COM DOENÇAS NEUROLÓGICAS E OSTEOMUSCULARES ATENDIDOS EM SERVIÇO DE REABILITAÇÃO VETERINÁRIA

Author

Figueiredo, Nuno Emanuel Oliveira, Luna, Stelio Pacca Loureiro, Joaquim, Jean Guilherme Fernandes, and Coutinho, Heloisa Dellacqua

Subjects
eletroacupuntura, disco intervertebral, electroacupuncture, intervertebral disc, osteoarthrosis, dor crônica, chronic pain, osteoartrose
Abstract

Resumo Este estudo retrospectivo avaliou 181 cães com doenças neurológicas e osteomusculares atendidos em um serviço de reabilitação e dor crônica, durante o período de 2013 a 2015. Objetivou-se caracterizar o perfil epidemiológico e clínico dos animais e analisar a eficácia da acupuntura (AP) e terapias afins e respectiva evolução clínica. O diagnóstico baseou-se no exame físico, neurológico, ortopédico e de imagem. As afecções mais prevalentes foram as do sistema nervoso central, sobretudo doença do disco toracolombar e traumas vertebromedulares agudos. Nas enfermidades neurológicas, o tratamento foi considerado eficaz quando os pacientes foram capazes de recuperar a deambulação e para as lesões medulares, quando houve melhora clínica do quadro neurológico avaliado por meio de escores. O sucesso obtido nos quatro segmentos medulares foi de 69,5%. Nas enfermidades osteomusculares, 47% dos cães apresentavam lesões no joelho e 44% displasia coxofemoral (DCF). Adotou-se a escala analógica visual (EAV) de locomoção para definir o sucesso do tratamento nestas doenças, que foi de 52,8%. As técnicas que mais se associaram à AP manual foram, por ordem decrescente, a eletroacupuntura, a ozonioterapia e o LASER. O número de sessões de AP foi em média de 7,6±3,5. Conclui-se que a AP e técnicas afins melhoraram o escore de déficit neurológico nas doenças neurológicas avaliadas quando usadas de forma isolada e quando associadas à medicina convencional. Abstract This retrospective study evaluated the clinical outcome of 181 dogs with neurologic and musculoskeletal diseases treated with acupuncture and related therapies at a rehabilitation service from 2013 to 2015. The diagnosis was based on physical, neurological and orthopedic examination, and radiography, MRI or CT. Neurological cases were the most prevalent, particularly intervertebral disk disease and spinal cord acute trauma. Treatment was considered successful in neurological cases when animals regained independent locomotion or in cases of spinal disease, when neurological scores changed from V, IV or III to II or I. The success achieved in the four spinal cord segments was 69.5%. For musculoskeletal diseases, 47% of the dogs had knee injuries and 24% had hip dysplasia. The visual analogue scale (VAS) of locomotion was adopted to define the success of treatment in these diseases, which was 52.8%. The techniques most associated with manual AP were in descending order electroacupuncture, ozone therapy and LASER. The mean number of AP sessions was 7.6±3.5. We concluded that AP and related techniques were effective to treat neurological diseases in dogs when used isolated or associated with conventional medicine.

Published
2018

45. Comparison of morphine, ketoprofen and arnica montana 6x and 30x per oral transmucosal or subcutaneous route for control of postoperative pain in cats subjected to hysterectomy with bilateral salpingo-oophorectomy

Author

Rodrigues, Denise de Fátima [UNESP], Luna, Stelio Pacca Loureiro [UNESP], Brondani, Juliana Tabarelli [UNESP], Minto, Bruno Watanabe [UNESP], and Universidade Estadual Paulista (Unesp)

Subjects
Spay, Homeopathy, Ovariohysterectomy, Analgesia
Abstract

Made available in DSpace on 2018-12-11T17:26:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-01. Added 1 bitstream(s) on 2019-10-09T18:32:20Z : No. of bitstreams: 1 S0103-84782016000200330.pdf: 291534 bytes, checksum: 802852fdcee8020e611ef226e9484f58 (MD5) The postoperative analgesic effect of Arnica montana (Arnica) was compared to morphine and ketoprofen in 50 cats following hysterectomy with bilateral salpingo-oophorectomy (HSO). Cats were randomly allocated to five groups (n=10) and were treated 30 minutes before surgery and over 72 hours with 1ml of Arnica 30x per subcutaneous (SC) route (GA30SC); Arnica 30x per oral transmucosal route (P.O.) (GA30PO); Arnica 6x P.O. (GA6PO); morphine 0.1mg kg1 SC (GM) SID or ketoprofen 2mg kg-1 SC (GK) before and 1mg kg1 after surgery. Sedation and postoperative pain were assessed by means of a dynamic and interactive visual analogue scale (DIVAS) and variable count scale (VCS) and hyperalgesia using an esthesiometer. Whenever the VAS and VCS scores attained 33% of the maximum value, rescue analgesia was performed with morphine 0.3mg kg1 per the intramuscular (IM) route. Other variables assessed were vomiting, defecation, urination, body weight and wound healing. Vomiting only occurred in animals treated with morphine. The groups did not differ in defecation, urination, body weight or wound healing. Hyperalgesia was detected only on the occasions that the criterion for rescue analgesia was met. One animal in GK and one in GM required rescue analgesia, differing from groups GA30SC, GA30PO and GA6PO, in which 4, 4 and 5 animals, respectively, required rescue analgesia. It can be concluded that ketoprofen and morphine were more efficacious than Arnica and that there was no difference among the various potencies and routes of administration of Arnica for postoperative analgesia in cats undergoing HSO. Faculdade de Medicina Veterinária e Zooctecnia (FMVZ) Universidade Estadual Paulista (UNESP) UNESP Faculdade de Medicina Veterinária e Zooctecnia (FMVZ) Universidade Estadual Paulista (UNESP) UNESP

Published
2016

47. Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets

Author

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, Barticciotto, Leticia Sturlini; Secretaria de Agricultura e Abastecimento do Estado de São Paulo, Luna, Stelio Pacca Loureiro; Faculdade de Medicina Veterinária e Zootecnia, Lorena, Sílvia Elaine Rodolfo de Sá; Universidade Federal Rural de Pernambuco, Telles, Filipe Garcia; Faculdade de Medicina Veterinária e Zootecnia, Berto, Dirlei Antônio; Faculdade de Medicina Veterinária e Zootecnia, Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, Barticciotto, Leticia Sturlini; Secretaria de Agricultura e Abastecimento do Estado de São Paulo, Luna, Stelio Pacca Loureiro; Faculdade de Medicina Veterinária e Zootecnia, Lorena, Sílvia Elaine Rodolfo de Sá; Universidade Federal Rural de Pernambuco, Telles, Filipe Garcia; Faculdade de Medicina Veterinária e Zootecnia, and Berto, Dirlei Antônio; Faculdade de Medicina Veterinária e Zootecnia

Abstract

The aim of this study was to investigate the effect of intratesticular local anesthesia on weight gain and behavioral and cortisol changes in piglets submitted to castration. Study design was a randomized controlled trial. Twenty-nine male Landrace crossbred piglets aged 3 to 6 days were used. The piglets were randomly divided into two groups: orchiectomy with anesthesia (A, n = 15) and orchiectomy without anesthesia (NOA, n = 14). Piglets in the A and NOA groups were treated with 0.5 mL of intratesticular 2% lidocaine with a vasoconstrictor in each testicle and 0.5 mL of intratesticular 0.9% sodium chloride, respectively. Blood samples were collected from all animals immediately after surgery and at 3 and 6 days postoperatively for measurement of the serum cortisol concentration. Behavior was assessed daily for 6 days by two observers blinded to the treatment. Weight was measured at the same time as cortisol measurement. Analysis of variance followed by the Student-Newman-Keuls test was used to investigate differences in time within and between the two groups. Mean times of six evaluations done for 90 minutes during 6 days of each behavior were compared by Tukey t test. The level of statistical significance was 5%. The serum cortisol concentration was higher immediately after surgery than at 3 and 6 days postoperatively in both groups. Weight gain was greater at 3 and 6 days postoperatively in the A group than in the NOA group. Intratesticular local anesthesia before castration in piglets is technically practical, is in accordance with good welfare practice, and improves short-term weight gain in piglets submitted to castration., O objetivo deste estudo foi investigar o efeito da anestesia local intratesticular prévia à castração sobre o ganho de peso, comportamento e alterações no cortisol de leitões. O delineamento experimental adotado foi inteiramente casualisado. Foram utilizados vinte e nove leitões mestiços Landrace – Large White do sexo masculino com idade de 3 a 6 dias. Os leitões foram divididos aleatoriamente em dois grupos: orquiectomia com anestesia (A, n = 15) e orquiectomia sem anestesia (NOA, n = 14). Aos leitões do grupo A foi administrado 0,5 mL de lidocaína 2% intratesticular com vasoconstritor em cada testículo, e no grupo NOA administrou-se 0,5 mL de NaCl 0,9% intra testicular também em cada testículo. Amostras de sangue foram coletadas de todos os animais imediatamente após a cirurgia e posteriormente aos 3 e 6 dias após a cirurgia para a medição da concentração de cortisol sérico. O comportamento foi avaliado diariamente durante 6 dias por dois observadores que desconheciam o tratamento. O peso foi medido ao mesmo tempo que o cortisol sanguíneo. Foi realizada a análise de variância, e o teste Student-Newman- Keuls para contraste entre médias. O tempo médio de seis avaliações realizadas por 90 minutos durante 6 dias para cada comportamento foi comparado pelo teste de Tukey. O nível de significância estatística foi de 5%. A concentração de cortisol sérico foi maior imediatamente após a cirurgia do que após 3 e 6 dias de pós-operatório em ambos os grupos. O ganho de peso foi superior aos 3 e 6 dias após a cirurgia no grupo A em relação ao grupo NOA. A anestesia local intratesticular antes da orquiectomia em leitões é prática, auxilia na manutenção das boas práticas de bem-estar animal, e melhora o ganho de peso a curto prazo em leitões submetidos à castração.

Published
2016

48. Efeitos hemodinâmicos da anestesia em plano profundo com infusão intravenosa contínua de propofol ou propofol associado à lidocaína em cães

Author

Mannarino, Rodrigo, Luna, Stelio Pacca Loureiro, Monteiro, Eduardo Raposo, Suzano, Sara Maria de Carvalho e, and Bressan, Thais Feres

Subjects
anestesia balanceada, eletroencefalografia, sistema cardiovascular, intravenous, balanced anesthesia, cardiovascular system, anesthesia, electroencephalography, anestesia intravenosa
Abstract

Os efeitos hemodinâmicos da anestesia total intravenosa com propofol ou propofol associado à lidocaína foram estudados em 12 cães. No grupo P (n=6), os animais receberam bolus de 6mg kg-1 de propofol e infusão contínua de 1,25mg kg-1 min-1. No grupo PL (n=6), os animais receberam bolus de 6mg kg-1 de propofol e 1,5mg kg-1 de lidocaína, seguido de infusão de 1,0mg kg-1 min-1 e 0,25mg kg-1 min-1, dos mesmos fármacos, respectivamente. Os animais foram instrumentados para mensuração das variáveis hemodinâmicas e do índice bispectral (BIS), aos 75, 90, 105 e 120 minutos de anestesia. Foram observados valores menores de índice cardíaco, índice sistólico, pressões arteriais sistólica, diastólica e média no grupo P do que no grupo PL (P

Published
2014

49. Medicina Veterinária: estudos resultantes do processo de articulação e integração dos cursos de Medicina Veterinária da UNESP

Author

Amorim, Rogério Martins [UNESP], Carvalho, Adolorata Aparecida Bianco [UNESP], Nunes, Cáris Maroni [UNESP], Macoris, Delphim da Graça [UNESP], Sartori, Denise Rangel da Silva [UNESP], Toniollo, Gilson Hélio [UNESP], Ferraz, Guilherme de Camargo [UNESP], Ciarlini, Luciana Del Rio Pinoti [UNESP], Mamprim, Maria Jaqueline [UNESP], Lopes, Raimundo Souza [UNESP], Luna, Stelio Pacca Loureiro [UNESP, Curvelo, Eliana [UNESP], and Universidade Estadual Paulista (Unesp)

Subjects
Universidade Estadual Paulista – Cursos de Medicina Veterinária
Abstract

Made available in DSpace on 2016-05-18T19:18:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-05-18T19:19:36Z : No. of bitstreams: 1 ISBN9788561134150.pdf: 12328795 bytes, checksum: 6f3ceb10cd76d868694f5197990c499d (MD5)

Published
2014

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