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21,793 results on '"Lund University [Lund]"'

1. Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation (STEPCARE)

Author: Lund University, Lund, Sweden, Copenhagen Trial Unit, Center for Clinical Intervention Research, The George Institute for Global Health, Australia, HUS Helsinki University Hospitals, Helsinki, Finland, and Medical Research Institute of New Zealand Rangahautia Te Ora, Wellington, New Zealand
Published: 2024

2. Trade‐Offs for Climate‐Smart Forestry in Europe Under Uncertain Future Climate

Author: Gregor, Konstantin, Knoke, Thomas, Krause, Andreas, Reyer, Christopher P. O., Lindeskog, Mats, Papastefanou, Phillip, Smith, Benjamin, Lansø, Anne‐Sofie, Rammig, Anja, 1 TUM School of Life Sciences Technical University of Munich Freising Germany, 2 Potsdam Institute for Climate Impact Research Member of the Leibniz Association Potsdam Germany, 3 Department of Physical Geography and Ecosystem Science Lund University Lund Sweden, 5 Department of Environmental Science Aarhus University Aarhus Denmark, Technische Universität München = Technical University of Munich (TUM), Potsdam Institute for Climate Impact Research (PIK), Lund University [Lund], Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Aarhus University [Aarhus]
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, SHORT-ROTATION COPPICE, UNMANAGED FORESTS, VEGETATION DYNAMICS, climate‐smart forestry, LAND-USE, forest management, substitution effects, robust optimization, ECOSYSTEM SERVICES, climate change mitigation, ddc, CARBON SEQUESTRATION, climate-smart forestry, ddc:634.9, Earth and Planetary Sciences (miscellaneous), MANAGEMENT, ddc:630, GREENHOUSE-GAS CONCENTRATIONS, LPJ-GUESS V4.0, ecosystem services, BIOMASS PRODUCTIVITY, GENERAL, Climate and interannual variability, Numerical modeling, NATURAL HAZARDS, Atmospheric, Geological, Oceanic, Physical modeling, Climate impact, Risk, Disaster risk analysis and assessment, OCEANOGRAPHY: PHYSICAL, Air/sea interactions, Decadal ocean variability, Ocean influence of Earth rotation, Sea level: variations and mean, Surface waves and tides, Tsunamis and storm surges, PALEOCEANOGRAPHY, POLICY SCIENCES, Benefit-cost analysis, RADIO SCIENCE, Radio oceanography, SEISMOLOGY, Earthquake ground motions and engineering seismology, Volcano seismology, TECTONOPHYSICS, Evolution of the Earth, VOLCANOLOGY, Volcano/climate interactions, Atmospheric effects, Volcano monitoring, Effusive volcanism, Mud volcanism, Explosive volcanism, Volcanic hazards and risks, GEOGRAPHIC LOCATION, Europe, Research Article, robust optimization [ATMOSPHERIC COMPOSITION AND STRUCTURE, Air/sea constituent fluxes, Biosphere/atmosphere interactions, Evolution of the atmosphere, Volcanic effects, BIOGEOSCIENCES, Modeling, Climate dynamics, COMPUTATIONAL GEOPHYSICS, Numerical solutions, CRYOSPHERE, Avalanches, Mass balance, GEODESY AND GRAVITY, Ocean monitoring with geodetic techniques, Ocean/Earth/atmosphere/hydrosphere/cryosphere interactions, Global change from geodesy, GLOBAL CHANGE, Impacts of global change, Land/atmosphere interactions, Abrupt/rapid climate change, Atmosphere, Climate variability, Earth system modeling, Oceans, Regional climate change, Sea level change, Solid Earth, Water cycles, HYDROLOGY, Climate impacts, Hydrological cycles and budgets, INFORMATICS, MARINE GEOLOGY AND GEOPHYSICS, Gravity and isostasy, ATMOSPHERIC PROCESSES, Climate change and variability, Climatology, General circulation, Ocean/atmosphere interactions, Regional modeling, Theoretical modeling, OCEANOGRAPHY], [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, General Environmental Science
Abstract: Forests mitigate climate change by storing carbon and reducing emissions via substitution effects of wood products. Additionally, they provide many other important ecosystem services (ESs), but are vulnerable to climate change; therefore, adaptation is necessary. Climate‐smart forestry combines mitigation with adaptation, whilst facilitating the provision of many ESs. This is particularly challenging due to large uncertainties about future climate. Here, we combined ecosystem modeling with robust multi‐criteria optimization to assess how the provision of various ESs (climate change mitigation, timber provision, local cooling, water availability, and biodiversity habitat) can be guaranteed under a broad range of climate futures across Europe. Our optimized portfolios contain 29% unmanaged forests, and implicate a successive conversion of 34% of coniferous to broad‐leaved forests (11% vice versa). Coppices practically vanish from Southern Europe, mainly due to their high water requirement. We find the high shares of unmanaged forests necessary to keep European forests a carbon sink while broad‐leaved and unmanaged forests contribute to local cooling through biogeophysical effects. Unmanaged forests also pose the largest benefit for biodiversity habitat. However, the increased shares of unmanaged and broad‐leaved forests lead to reductions in harvests. This raises the question of how to meet increasing wood demands without transferring ecological impacts elsewhere or enhancing the dependence on more carbon‐intensive industries. Furthermore, the mitigation potential of forests depends on assumptions about the decarbonization of other industries and is consequently crucially dependent on the emission scenario. Our findings highlight that trade‐offs must be assessed when developing concrete strategies for climate‐smart forestry., Plain Language Summary: Forests help mitigate climate change by storing carbon and via avoided emissions when wood products replace more carbon‐intensive materials. At the same time, forests provide many other “ecosystem services (ESs)” to society. For example, they provide timber, habitat for various species, and they cool their surrounding regions. They are, however, also vulnerable to ongoing climate change. Forest management must consider all these aspects, which is particularly challenging considering the uncertainty about future climate. Here, we propose how this may be tackled by computing optimized forest management portfolios for Europe for a broad range of future climate pathways. Our results show that changes to forest composition are necessary. In particular, increased shares of unmanaged and broad‐leaved forests are beneficial for numerous ESs. However, these increased shares also lead to decreases in harvest rates, posing a conflict between wood supply and demand. We further show that the mitigation potential of forests strongly depends on how carbon‐intensive the replaced materials are. Consequently, should these materials become “greener” due to new technologies, the importance of wood products in terms of climate change mitigation decreases. Our study highlights that we cannot optimize every aspect, but that trade‐offs between ESs need to be made., Key Points: Strategies for climate‐smart forestry under a range of climate scenarios always lead to trade‐offs between different ecosystem services (ESs). Higher shares of unmanaged and broad‐leaved forests are beneficial for numerous ESs, but lead to decreased timber provision. The mitigation potential of forests strongly relies on substitution effects which depend on the carbon‐intensity of the alternative products., European Forest Institute (EFI) Networking Fund http://dx.doi.org/10.13039/501100013942, Bayerisches Staatsministerium für Wissenschaft und Kunst, Bayerisches Netzwerk für Klimaforschung (BayKliF) http://dx.doi.org/10.13039/501100004563, Swedish Research Council Formas, German Federal Office for Agriculture and Food (BLE), https://doi.org/10.5281/zenodo.6667489, https://doi.org/10.5281/zenodo.6612953
Published: 2022
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3. Origin and fate of dissolved organic matter in four shallow Baltic Sea estuaries

Author: Voss, Maren, Asmala, Eero, Bartl, Ines, Carstensen, Jacob, Conley, Daniel J., Dippner, Joachim W., Humborg, Christoph, Lukkari, Kaarina, Petkuviene, Jolita, Reader, Heather, Stedmon, Colin, Vybernaite-Lubiene, Irma, Wannicke, Nicola, Zilius, Mindaugas, Biological Oceanography, Leibniz Institute for Baltic Sea Research, Warnemünde, Germany, Tvärminne Zoological Station, University of Helsinki, Hanko, Finland, Department of Bioscience, Aarhus University, Roskilde, Denmark, Department of Geology, Lund University, Lund, Sweden, Stockholms Universitets Östersjöcentrum, Stockholm, Sweden, Finnish Environment Institute, Marine Research Centre, Helsinki, Finland, Marine Research Institute, Klaipeda University, Klaipeda, Lithuania, Department of Chemistry, Memorial University of Newfoundland, St. John’s, Canada, National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark, Leibniz Institute für Plasmaforschung und Technologie e.V., Greifswald, Germany, Ecosystems and Environment Research Programme, Biological stations, Marine Ecosystems Research Group, Tvärminne Zoological Station, and Aquatic Biogeochemistry Research Unit (ABRU)
Subjects: 1171 Geosciences, DYNAMICS, 0106 biological sciences, Freshwater inflow, Baltic Sea, 010504 meteorology & atmospheric sciences, BIOAVAILABILITY, Fjord, Riverine input, 01 natural sciences, CARBON, coastal systems, dissolved organic matter, Dissolved organic carbon, Tributary, Environmental Chemistry, Coastal systems, Dissolved organic matter, Organic matter, 14. Life underwater, SDG 15 - Life on Land, 0105 earth and related environmental sciences, Earth-Surface Processes, Water Science and Technology, chemistry.chemical_classification, geography, geography.geographical_feature_category, LAND-USE, Brackish water, 010604 marine biology & hydrobiology, RIVER PLUME, CONSUMPTION, Estuary, 6. Clean water, NITROGEN, PHOSPHORUS, Oceanography, chemistry, 13. Climate action, EUTROPHICATION, ddc:551.9, Environmental science, Eutrophication, MARINE
Abstract: Coastal waters have strong gradients in dissolved organic matter (DOM) quantity and characteristics, originating from terrestrial inputs and autochthonous production. Enclosed seas with high freshwater input therefore experience high DOM concentrations and gradients from freshwater sources to more saline waters. The brackish Baltic Sea experiences such salinity gradients from east to west and from river mouths to the open sea. Furthermore, the catchment areas of the Baltic Sea are very diverse and vary from sparsely populated northern areas to densely populated southern zones. Coastal systems vary from enclosed or open bays, estuaries, fjords, archipelagos and lagoons where the residence time of DOM at these sites varies and may control the extent to which organic matter is biologically, chemically or physically modified or simply diluted with transport off-shore. Data of DOM with simultaneous measurements of dissolved organic (DO) nitrogen (N), carbon (C) and phosphorus (P) across a range of contrasting coastal systems are scarce. Here we present data from the Roskilde Fjord, Vistula and Öre estuaries and Curonian Lagoon; four coastal systems with large differences in salinity, nutrient concentrations, freshwater inflow and catchment characteristics. The C:N:P ratios of DOM of our data, despite high variability, show site specific significant differences resulting largely from differences residence time. Microbial processes seemed to have minor effects, and only in spring did uptake of DON in the Vistula and Öre estuaries take place and not at the other sites or seasons. Resuspension from sediments impacts bottom waters and the entire shallow water column in the Curonian Lagoon. Finally, our data combined with published data show that land use in the catchments seems to impact the DOC:DON and DOC:DOP ratios of the tributaries most., Academy of Sciences of Finland, Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659, BONUS COCOA and Bundesministerium für Bildung und Forschung, Academy of Finland, Danish Research Council for Independent Research, BONUS COCOA Project, Leibniz-Institut für Ostseeforschung Warnemünde (IOW) (3484)
Published: 2020
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4. Fourth European stroke science workshop

Author: Paris 5, INSERM U894, Paris, France (JCB), Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland (KN), Stroke Trials Unit, University of Nottingham, Nottingham NG5 1PB UK (PMB), Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (TJQ), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (ER), Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany (UZ), Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany (AL, MDü), Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (AL, MDü), Department of Medicine, University of Thessaly, Larissa, Greece (GN), Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA (CI), Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom (KRL), University of Copenhagen, Bispebjerg Hospital, Department of Neurology, Copenhagen, Denmark (HC), Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA (SJvW), Sydney Medical School, University of Sydney, Sydney, Australia (CSA), Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton, UK (CAM), Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, Bordeaux School of Public. Health, Bordeaux, France (CD), CHU de Bordeaux, Pôle de santé, publique, Bordeaux, France (CD), Center of Functionally Integrative Neuroscience, 53154 Aarhus University, Aarhus, Denmark (LO), Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (NJS), Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Switzerland (UF, HM), Radboud University Nijmegen Medical Center, Donders Institute Brain Cognition & Behaviour, Center for Neuroscience Department of Neurology, Nijmegen, The Netherlands (FEdL), Department of Neurology, Lund University, Lund, Sweden (BN), Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER), Univ. Lille, Inserm, CHU Lille, Degenerative and Vascular Cognitive Disorders, Lille, France (CC), Department of Neurology, Sainte-Anne Hospital, INSERM 894, DHU NeuroVasc Sorbonne Paris-Cité, Paris Descartes University, Paris, France (JLM), Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (VC), Department of Neurology, Charité, Universitätsmedizin Berlin, Berlin, Germany (EM), on behalf of the European Stroke Science Workshop Presenters and Co-convenors, INSERM U1161, UFR de médecine Paris Diderot, France (ETL), Department of Neurology, Cologne University Hospital, Köln, Germany (CG), HRB Stroke Clinical Trials Network Ireland, University College Dublin Ireland (PJK), University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom (KM), Dept of Internal Medicine, Oslo University Hospital, Oslo, and Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway (EB), Sorbonne Universités, UPMC Université, Paris 06, INSERM UMR-S 1166, F-75013, Paris, France (DAT), ICAN Institute for Cardiometabolism and Nutrition, Paris, France (DAT), University Hospital of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom (CR), Department Neurosciences and Preventive Medicine, Danube University Krems, Austria (MB), Department of Neurosurgery, Bern University Hospital, Inselspital, Bern, Switzerland (JB), Department of Neurology, University of Heidelberg, Heidelberg, Germany (TS), Department of Neurology, Slotervaart Medical Center, Amsterdam, The Netherlands (LMdL), University Paris Diderot, Paris, France (EJ), Department of Neurology, University of Heidelberg, Heidelberg, Germany (RV), and Department of Neurology, Hopital Sainte-Anne, Université
Subjects: Stroke, small vessel disease, stroke therapy, thrombectomy, genomics, Clinical Neurology, stroke recovery, Cardiology and Cardiovascular Medicine, intracerebral hemorrhage, vascular cognitive impairment
Abstract: Lake Eibsee, Garmisch-Partenkirchen, 16 to 18 November, 2017: The European Stroke Organisation convened >120 stroke experts from 21 countries to discuss latest results and hot topics in clinical, translational and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a cornerstone of European Stroke Organisation’s academic activities and a major highlight for researchers in the field. Participants include stroke researchers at all career stages and with different backgrounds, who convene for plenary lectures and discussions. The workshop was organised in seven scientific sessions focusing on the following topics: (1) acute stroke treatment and endovascular therapy; (2) small vessel disease; (3) opportunities for stroke research in the omics era; (4) vascular cognitive impairment; (5) intracerebral and subarachnoid haemorrhage; (6) alternative treatment concepts and (7) neural circuits, recovery and rehabilitation. All sessions started with a keynote lecture providing an overview on current developments, followed by focused talks on a timely topic with the most recent findings, including unpublished data. In the following, we summarise the key contents of the meeting. The program is provided in the online only Data Supplement. The workshop started with a key note lecture on how to improve the efficiency of clinical trial endpoints in stroke, which was delivered by Craig Anderson (Sydney, Australia) and set the scene for the following discussions.
Published: 2018

5. Systematic trends in beta-delayed particle emitting nuclei: The case of βpα emission from 21 Mg

Author: Lund, M.V.Department of Physics and Astronomy, Aarhus University, Aarhus C, DK-8000, Denmark, Borge, M.J.G.(ISOLDE, PH Department, CERN, Geneve 23, CH-1211, Switzerland), Briz, J.A.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Cederkäll, J.(Department of Nuclear Physics, Lund University, Lund, SE-221 00, Sweden), Fynbo, H.O.U.(Department of Physics and Astronomy, Aarhus University, Aarhus C, DK-8000, Denmark), Jensen, J.H.(Department of Physics and Astronomy, Aarhus University, Aarhus C, DK-8000, Denmark), Jonson, B.(Fundamental Fysik, Chalmers Tekniska Högskola, Göteborg, SE-41296, Sweden), Laursen, K.L.(Department of Physics and Astronomy, Aarhus University, Aarhus C, DK-8000, Denmark), Nilsson, T.(Fundamental Fysik, Chalmers Tekniska Högskola, Göteborg, SE-41296, Sweden), Perea, A.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Pesudo, V.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Riisager, K.(Department of Physics and Astronomy, Aarhus University, Aarhus C, DK-8000, Denmark), and Tengblad, O.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain)
Subjects: Physics::Accelerator Physics, Nuclear Experiment
Abstract: We have observed β+ -delayed α and pα emission from the proton-rich nucleus 21 Mg produced at the ISOLDE facility at CERN. The assignments were cross-checked with a time distribution analysis. This is the third identified case of βpα emission. We discuss the systematic of beta-delayed particle emission decays, show that our observed decays fit naturally into the existing pattern, and argue that the patterns are to a large extent caused by odd–even effects.
Published: 2015

6. A model to predict cardiovascular events in patients with newly diagnosed Wegener's granulomatosis and microscopic polyangiitis

Author: University of Michigan, Ann Arbor ; Dr. McCune has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Genentech and has received research support from Genentech and Human Genome Sciences., Nuffield Orthopaedic Centre, Oxford, UK ; Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK, Oxford National Institute for Health Research and University of Oxford, Oxford, UK, Addenbrooke's Hospital, Cambridge, UK, University of Birmingham, Birmingham, UK, Lund University, Lund, Sweden, Norfolk and Norwich University Hospital, Norwich, UK, Genentech Corporation, South San Francisco, and University of California, San Francisco, Cleveland Clinic, Cleveland, Ohio, Boston University School of Medicine, Boston, Massachusetts, Duke University, Durham, North Carolina, Johns Hopkins University, Baltimore, Maryland, Hospital for Special Surgery, New York, New York, Massachusetts General Hospital, Boston, Nuffield Orthopaedic Centre, Oxford National Institute for Health Research, and University of Oxford, Oxford, UK, Suppiah, Ravi, Judge, Andrew, Batra, Rajbir, Flossmann, Oliver, Harper, Lorraine, H??glund, Peter, Javaid, M. Kassim, Jayne, David, Mukhtyar, Chetan, Westman, Kerstin, Davis, John C., Hoffman, Gary S., McCune, W. Joseph, Merkel, Peter A., St. Clair, E. William, Seo, Philip, Spiera, Robert, Stone, John H., Luqmani, Raashid, University of Michigan, Ann Arbor ; Dr. McCune has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Genentech and has received research support from Genentech and Human Genome Sciences., Nuffield Orthopaedic Centre, Oxford, UK ; Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK, Oxford National Institute for Health Research and University of Oxford, Oxford, UK, Addenbrooke's Hospital, Cambridge, UK, University of Birmingham, Birmingham, UK, Lund University, Lund, Sweden, Norfolk and Norwich University Hospital, Norwich, UK, Genentech Corporation, South San Francisco, and University of California, San Francisco, Cleveland Clinic, Cleveland, Ohio, Boston University School of Medicine, Boston, Massachusetts, Duke University, Durham, North Carolina, Johns Hopkins University, Baltimore, Maryland, Hospital for Special Surgery, New York, New York, Massachusetts General Hospital, Boston, Nuffield Orthopaedic Centre, Oxford National Institute for Health Research, and University of Oxford, Oxford, UK, Suppiah, Ravi, Judge, Andrew, Batra, Rajbir, Flossmann, Oliver, Harper, Lorraine, H??glund, Peter, Javaid, M. Kassim, Jayne, David, Mukhtyar, Chetan, Westman, Kerstin, Davis, John C., Hoffman, Gary S., McCune, W. Joseph, Merkel, Peter A., St. Clair, E. William, Seo, Philip, Spiera, Robert, Stone, John H., and Luqmani, Raashid
Abstract: Objective To create a prognostic tool to quantify the 5-year cardiovascular (CV) risk in patients with newly diagnosed Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) without premorbid CV disease. Methods We reviewed CV outcomes during the long-term followup of patients in the first 4 European Vasculitis Study Group (EUVAS) trials of WG and MPA. CV events were defined as CV death, stroke, myocardial infarction, coronary artery bypass graft, or percutaneous coronary intervention. Logistic regression was performed to create a model to predict the absolute risk of a CV event. The model was tested using the Wegener's Granulomatosis Etanercept Trial (WGET) cohort. Results Seventy-four (13.8%) of 535 patients with 5 years of followup from the EUVAS trials had at least 1 CV event: 33 (11.7%) of 281 WG versus 41 (16.1%) of 254 MPA. The independent determinants of CV outcomes were older age (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.11???1.90), diastolic hypertension (OR 1.97, 95% CI 0.98???3.95), and positive proteinase 3 (PR3) antineutrophil cytoplasmic antibody (ANCA) status (OR 0.39, 95% CI 0.20???0.74). The model was validated using the WGET cohort (area under the receiver operating characteristic curve of 0.80). Conclusion Within 5 years of diagnosis of WG or MPA, 14% of patients will have a CV event. We have constructed and validated a tool to quantify the risk of a CV event based on age, diastolic hypertension, and PR3 ANCA status in patients without prior CV disease. In patients with vasculitis, PR3 ANCA is associated with a reduced CV risk compared to myeloperoxidase ANCA or negative ANCA status.
Published: 2011

7. Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

Author: 1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., Gordon, C., 1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., and Gordon, C.
Abstract: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files, OBJECTIVE: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. METHODS: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the revised SELENA flare index [rSFI]). The 451 patient case histories were distributed to 18 pairs of physicians, carefully randomized in a manner designed to ensure a fair case mix and equal distribution of flare according to severity. RESULTS: The 3-physician assessment of flare matched the level of flare using the 3 indices, with 67% for BILAG 2004, 72% for SFI, and 70% for rSFI. The corresponding weighted kappa coefficients for each instrument were 0.82, 0.59, and 0.74, respectively. We undertook a detailed analysis of the discrepant cases and several factors emerged, including a tendency to score moderate flares as severe and persistent activity as flare, especially when the SFI and rSFI instruments were used. Overscoring was also driven by scoring treatment change as flare, even if there were no new or worsening clinical features. CONCLUSION: Given the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.

8. The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics

Author: [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, Olsen, Jørgen H., [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, and Olsen, Jørgen H.
Abstract: To access publisher's full text version of this article click on the hyperlink at the bottom of the page, Background. During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Procedure. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. Results. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. Conclusion. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood.

9. The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics

Author: [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, Olsen, Jørgen H., [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, and Olsen, Jørgen H.
Abstract: To access publisher's full text version of this article click on the hyperlink at the bottom of the page, Background. During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Procedure. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. Results. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. Conclusion. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood.

10. The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics

Author: [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, Olsen, Jørgen H., [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, and Olsen, Jørgen H.
Abstract: To access publisher's full text version of this article click on the hyperlink at the bottom of the page, Background. During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Procedure. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. Results. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. Conclusion. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood.

11. The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics

Author: [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, Olsen, Jørgen H., [ 1 ] Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus N, Denmark [ 2 ] Danish Canc Soc, Res Ctr, Copenhagen, Denmark [ 3 ] Landspitali Univ Hosp, Childrens Hosp Iceland, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital [ 4 ] Lund Univ, Dept Clin Sci, Canc Epidemiol, Lund, Sweden [ 5 ] Finnish Canc Registry, FIN-00170 Helsinki, Finland [ 6 ] Jorvi Cent Hosp, Dept Pediat, Espoo, Finland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 8 ] Iceland Canc Registry, Reykjavik, Iceland [ 9 ] Norwegian Canc Registry, Oslo, Norway [ 10 ] Lund Univ, Skane Univ Hosp, Dept Clin Sci Pediat Oncol & Hematol, Lund, Sweden, Department of Pediatrics; Aarhus University Hospital; Aarhus Denmark, Danish Cancer Society Research Center; Copenhagen; Denmark, Department of Clinical Sciences; Lund, Cancer Epidemiology, Lund University; Sweden, Finnish Cancer Registry; Helsinki; Finland, Faculty of Medicine; University of Iceland; Reykjavik Iceland, Norwegian Cancer Registry; Oslo; Norway, Department of Clinical Sciences; Pediatric Oncology and Hematology, Skåne University Hospital, Lund University; Lund Sweden, Asdahl, Peter H., Winther, Jeanette F., Bonnesen, Trine G., De Fine Licht, Sofie, Gudmundsdottir, Thorgerdur, Anderson, Harald, Madanat-Harjuoja, Laura, Tryggvadottir, Laufey, Småstuen, Milada Cvancarova, Holmqvist, Anna Sällfors, Hasle, Henrik, and Olsen, Jørgen H.
Abstract: To access publisher's full text version of this article click on the hyperlink at the bottom of the page, Background. During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Procedure. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. Results. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. Conclusion. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood.

12. DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.

Author: Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 2Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. 3Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. 4Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. 5Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain. 6IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. 7Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain. 8Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 9Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain. 10Oncogenetics Laboratory, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Institut de Recerca (VHIR), and Universitat Autonoma de Barcelona, Barcelona, Spain. 11Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 12Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece. 13Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain. 14Medical Oncology Service, Hospital Clínico Lozano Blesa, San Juan Bosco, Zaragoza, Spain. 15Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada. 16Department of Oncology, Lund University, Lund, Sweden. 17Department of Oncology, Karolinska University Hospital, Stockholm, Sweden. 18Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. 19Department of Oncology, Lund University Hospital, Lund, Sweden. 20Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. 21Center for Clinical Cancer Genet, Osorio, Ana, Milne, Roger L, Kuchenbaecker, Karoline, Vaclová, Tereza, Pita, Guillermo, Alonso, Rosario, Peterlongo, Paolo, Blanco, Ignacio, de la Hoya, Miguel, Duran, Mercedes, Díez, Orland, Mai, Phuong L, Neuhausen, Susan L, Lejbkowicz, Flavio, Ottini, Laura, Lee, Andrew, Buys, Saundra S, Thomassen, Mads, Zaffaroni, Daniela, Andrulis, Irene, Benitez, Javier, Schmutzler, Rita Katharina, Eccles, Diana, Swe-Brca, Platte, Radka, Hodgson, Shirley, Tischkowitz, Marc, Meindl, Alfons, van Deurzen, Carolien H M, Nathanson, Katherine, Donaldson, Alan, Varon-Mateeva, Raymonda, Teulé, Alex, Walsh, Christine, Poppe, Bruce, Ditsch, Nina, Arver, Brita, Morrison, Patrick, Plendl, Hans Jörg, Sutter, Christian, Rantala, Johanna, Johannsson, Oskar Th, Janavicius, Ramunas, Wappenschmidt, Barbara, Stoppa-Lyonnet, Dominique, Brewster, Wendy, Olswold, Curtis, Ding, Yuan Chun, Rookus, Matti A, Lester, Jenny, John, Esther M, Gehrig, Andrea, Herzog, Josef, Lalloo, Fiona, Kauff, Noah, Whittemore, Alice S, Rau-Murthy, Rohini, Weeman, Kisa, Claes, Kathleen, Rutherford, Thomas, Gómez Garcia, Encarna B, Berger, Andreas, Bonanni, Bernardo, Hebon, Hansen, Thomas V O, Rhiem, Kerstin, Jønson, Lars, Wakeley, Katie, Garber, Judy, Foo, Claire, Toland, Amanda Ewart, Ejlertsen, Bent, Pedersen, Inge Sokilde, Ellis, Steve, van Os, Theo A M, Collée, J Margriet, van der Luijt, Rob B, Lubinski, Jan, Simard, Jacques, Izatt, Louise, Teixeira, Manuel R, Mariette, Frederique, Piedmonte, Marion, Volorio, Sara, Hoogerbrugge, Nicoline, Porteous, Mary, Mazoyer, Sylvie, Wang-Gohrke, Shan, Martínez-Bouzas, Cristina, Viel, Alessandra, Soucy, Penny, Side, Lucy, Olah, Edith, Jaworska-Bieniek, Katarzyna, Maugard, Christine, Vijai, Joseph, Beattie, Mary S, Godwin, Andrew K, Investigators, Kconfab, Geschwantler Kaulich, Daphne, Eeles, Ros, van der Kolk, Lizet, Adlard, Julian, Durda, Katarzyna, Steinemann, Doris, Nevanlinna, Heli, Douglas, Fiona, Lázaro, Conxi, Davidson, Rosemarie, Engel, Christoph, Robson, Mark, Preisler-Adams, Sabine, Healey, Sue, Zhang, Liying, Fink-Retter, Anneliese, Mulligan, Anna Marie, Terry, Mary B, Damiola, Francesca, Tea, Muy-Kheng, Friedman, Eitan, Tucker, Kathy, Couch, Fergus J, Glendon, Gord, Kast, Karin, Pfeiler, Georg, Bojesen, Anders, Sunde, Lone, Ramón Y Cajal, Teresa, Moreno, Leticia Thais, Aittomäki, Kristiina, Shimon, Shani Paluch, Loman, Niklas, Scuvera, Giulietta, de Lange, J L, Rebbeck, Timothy R, Konstantopoulou, Irene, Backes, Floor, Laitman, Yael, Andrés Conejero, Raquel, McGuffog, Lesley, Rodríguez, Gustavo, Radice, Paolo, Devilee, Peter, Chenevix-Trench, Georgia, Olopade, Olufunmilayo I, Daly, Mary B, Evans, Gareth, Menéndez, Mireia, Dorfling, Cecilia M, Meijers-Heijboer, Hanne E J, van der Hout, A H, Ehrencrona, Hans, Montagna, Marco, Phelan, Catherine M, Cook, Jackie, van Asperen, Christi J, Brewer, Carole, Tognazzo, Silvia, Arun, Banu K, Hopper, John, Gerdes, Anne-Marie, Kennedy, John, Guidugli, Lucia, Manoukian, Siranoush, Jakubowska, Anna, Antoniou, Antonis C, Cybulski, Cezary, Southey, Melissa, Singer, Christian F, Easton, Douglas F, Arnold, Norbert, Gronwald, Jacek, Niederacher, Dieter, Rappaport, Christine, van Rensburg, Elizabeth J, Herráez, Belén, Weitzel, Jeffrey N, Varesco, Liliana, Sinilnikova, Olga M, Greene, Mark H, Frost, Debra, Lindor, Noralane, Karlan, Beth Y, Slager, Susan, Infante, Mar, Kruse, Torben A, Domchek, Susan M, Barrowdale, Daniel, Steele, Linda, Szabo, Csilla I, Papi, Laura, Jensen, Uffe Birk, Peissel, Bernard, Tibiletti, Maria Grazia, Yannoukakos, Drakoulis, Cole, Trevor, Caldés, Trinidad, Offit, Kenneth, Fineberg, Elena, Walker, Lisa, Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 2Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. 3Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. 4Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. 5Genotyping Unit (CeGen), Spanish National Cancer Centre (CNIO), Madrid, Spain. 6IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy. 7Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain. 8Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 9Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain. 10Oncogenetics Laboratory, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Institut de Recerca (VHIR), and Universitat Autonoma de Barcelona, Barcelona, Spain. 11Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 12Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece. 13Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain. 14Medical Oncology Service, Hospital Clínico Lozano Blesa, San Juan Bosco, Zaragoza, Spain. 15Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada. 16Department of Oncology, Lund University, Lund, Sweden. 17Department of Oncology, Karolinska University Hospital, Stockholm, Sweden. 18Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. 19Department of Oncology, Lund University Hospital, Lund, Sweden. 20Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. 21Center for Clinical Cancer Genet, Osorio, Ana, Milne, Roger L, Kuchenbaecker, Karoline, Vaclová, Tereza, Pita, Guillermo, Alonso, Rosario, Peterlongo, Paolo, Blanco, Ignacio, de la Hoya, Miguel, Duran, Mercedes, Díez, Orland, Mai, Phuong L, Neuhausen, Susan L, Lejbkowicz, Flavio, Ottini, Laura, Lee, Andrew, Buys, Saundra S, Thomassen, Mads, Zaffaroni, Daniela, Andrulis, Irene, Benitez, Javier, Schmutzler, Rita Katharina, Eccles, Diana, Swe-Brca, Platte, Radka, Hodgson, Shirley, Tischkowitz, Marc, Meindl, Alfons, van Deurzen, Carolien H M, Nathanson, Katherine, Donaldson, Alan, Varon-Mateeva, Raymonda, Teulé, Alex, Walsh, Christine, Poppe, Bruce, Ditsch, Nina, Arver, Brita, Morrison, Patrick, Plendl, Hans Jörg, Sutter, Christian, Rantala, Johanna, Johannsson, Oskar Th, Janavicius, Ramunas, Wappenschmidt, Barbara, Stoppa-Lyonnet, Dominique, Brewster, Wendy, Olswold, Curtis, Ding, Yuan Chun, Rookus, Matti A, Lester, Jenny, John, Esther M, Gehrig, Andrea, Herzog, Josef, Lalloo, Fiona, Kauff, Noah, Whittemore, Alice S, Rau-Murthy, Rohini, Weeman, Kisa, Claes, Kathleen, Rutherford, Thomas, Gómez Garcia, Encarna B, Berger, Andreas, Bonanni, Bernardo, Hebon, Hansen, Thomas V O, Rhiem, Kerstin, Jønson, Lars, Wakeley, Katie, Garber, Judy, Foo, Claire, Toland, Amanda Ewart, Ejlertsen, Bent, Pedersen, Inge Sokilde, Ellis, Steve, van Os, Theo A M, Collée, J Margriet, van der Luijt, Rob B, Lubinski, Jan, Simard, Jacques, Izatt, Louise, Teixeira, Manuel R, Mariette, Frederique, Piedmonte, Marion, Volorio, Sara, Hoogerbrugge, Nicoline, Porteous, Mary, Mazoyer, Sylvie, Wang-Gohrke, Shan, Martínez-Bouzas, Cristina, Viel, Alessandra, Soucy, Penny, Side, Lucy, Olah, Edith, Jaworska-Bieniek, Katarzyna, Maugard, Christine, Vijai, Joseph, Beattie, Mary S, Godwin, Andrew K, Investigators, Kconfab, Geschwantler Kaulich, Daphne, Eeles, Ros, van der Kolk, Lizet, Adlard, Julian, Durda, Katarzyna, Steinemann, Doris, Nevanlinna, Heli, Douglas, Fiona, Lázaro, Conxi, Davidson, Rosemarie, Engel, Christoph, Robson, Mark, Preisler-Adams, Sabine, Healey, Sue, Zhang, Liying, Fink-Retter, Anneliese, Mulligan, Anna Marie, Terry, Mary B, Damiola, Francesca, Tea, Muy-Kheng, Friedman, Eitan, Tucker, Kathy, Couch, Fergus J, Glendon, Gord, Kast, Karin, Pfeiler, Georg, Bojesen, Anders, Sunde, Lone, Ramón Y Cajal, Teresa, Moreno, Leticia Thais, Aittomäki, Kristiina, Shimon, Shani Paluch, Loman, Niklas, Scuvera, Giulietta, de Lange, J L, Rebbeck, Timothy R, Konstantopoulou, Irene, Backes, Floor, Laitman, Yael, Andrés Conejero, Raquel, McGuffog, Lesley, Rodríguez, Gustavo, Radice, Paolo, Devilee, Peter, Chenevix-Trench, Georgia, Olopade, Olufunmilayo I, Daly, Mary B, Evans, Gareth, Menéndez, Mireia, Dorfling, Cecilia M, Meijers-Heijboer, Hanne E J, van der Hout, A H, Ehrencrona, Hans, Montagna, Marco, Phelan, Catherine M, Cook, Jackie, van Asperen, Christi J, Brewer, Carole, Tognazzo, Silvia, Arun, Banu K, Hopper, John, Gerdes, Anne-Marie, Kennedy, John, Guidugli, Lucia, Manoukian, Siranoush, Jakubowska, Anna, Antoniou, Antonis C, Cybulski, Cezary, Southey, Melissa, Singer, Christian F, Easton, Douglas F, Arnold, Norbert, Gronwald, Jacek, Niederacher, Dieter, Rappaport, Christine, van Rensburg, Elizabeth J, Herráez, Belén, Weitzel, Jeffrey N, Varesco, Liliana, Sinilnikova, Olga M, Greene, Mark H, Frost, Debra, Lindor, Noralane, Karlan, Beth Y, Slager, Susan, Infante, Mar, Kruse, Torben A, Domchek, Susan M, Barrowdale, Daniel, Steele, Linda, Szabo, Csilla I, Papi, Laura, Jensen, Uffe Birk, Peissel, Bernard, Tibiletti, Maria Grazia, Yannoukakos, Drakoulis, Cole, Trevor, Caldés, Trinidad, Offit, Kenneth, Fineberg, Elena, and Walker, Lisa
Abstract: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access., Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7 × 10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03-1.21, p = 4.8 × 10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.

13. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score

Author: Amanda J. Cross, Kristin Benjaminsen Borch, Anne Kirstine Eriksen, Elio Riboli, José María Huerta, H. Bas Bueno-de-Mesquita, Giovanna Masala, Núria Sala, Anne Tjønneland, Anika Hüsing, Rudolf Kaaks, Sara Grioni, Anne M. May, Fanny Artaud, Antonia Trichopoulou, Pilar Amiano, Eleni Peppa, Marc J. Gunter, Timothy J. Key, Aurelio Barricarte Gurrea, Jonna Berntsson, Anna Karakatsani, Mazda Jenab, Elisabete Weiderpass, Isabel Drake, Christina C. Dahm, Torkjel M. Sandanger, Bethany Van Guelpen, Robin Reichmann, María José Sánchez, Guri Skeie, Konstantinos K. Tsilidis, Gianluca Severi, Carlotta Sacerdote, Sjoerd G. Elias, José Ramón Quirós, Marie-Christine Boutron-Ruault, Salvatore Panico, Krasimira Aleksandrova, Rosario Tumino, Sophia Harlid, Elom K. Aglago, [Aleksandrova,K, Reichmann,R] Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. [Aleksandrova,K, Reichmann,R] Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. [Aleksandrova,K] Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. [Kaaks,R, Hüsing,A] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Jenab,M, Weiderpass,E, Aglago,EK, Gunter,MJ] International Agency for Research on Cancer, World Health Organization, Lyon, France. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Bueno-de-Mesquita,HB, Cross,AJ, Tsilidis,KK, Riboli,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Dahm,CC] Department of Public Health, Aarhus University, Aarhus, Denmark. [Eriksen,AK, Tjønneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Artaud,F, Boutron-Ruault,MC, Severi,G] CESP, Faculté de Medicine, Université Paris-Saclay, Villejuif, France. [Artaud,F, Severi,G] Institut Gustave Roussy, Villejuif, France. [Severi,G] Dipartimento di Statistica, Informatica e Applicazioni 'G. Parenti' (DISIA), University of Florence, Florence, Italy. [Trichopoulou,A, Karakatsani,A, Peppa,E] Hellenic Health Foundation, Athens, Greece. [Karakatsani,A] 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, 'ATTIKON' University Hospital, Haidari, Greece. [Panico,S] EPIC Centre of Naples, Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy. [Masala,G] 1Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy. [Grioni,S] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. [Sacerdote,C] Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy. [Tumino,R] Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy. [Elias,SG, May,AM] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. [Borch,KB, Sandanger,TM, Skeie,G] Department of Community Medicine, Health Faculty, UiT-the Arctic university of Norway, Tromsø, Norway. [Sánchez,MJ] Escuela Andaluza de Salud Pública (EASP), Granada, Spain. [Sánchez,MJ] Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. [Sánchez,MJ, Huerta,JM, Gurrea,AB, Amiano,P] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Sánchez,MJ] Universidad de Granada, Granada, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Sala,N] Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Barcelona, Spain. [Sala,N] Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Gurrea,AB] Navarra Public Health Institute, Pamplona, Spain. [Gurrea,AB] Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Amiano,P] Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain. [Berntsson,J] Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden. [Drake,I] Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. [van Guelpen,B, Harlid,S] Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. [van Guelpen,B] Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. [Key,T] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Tsilidis,KK] Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., This work was supported by the German Research Foundation (DFG) (grant AL 1784/3-1), which funded the research position of Dr. Aleksandrova for organizing study conduct and analysis. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) and Federal Ministry of Education and Research (BMBF) (Germany), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), Health Research Fund (FIS), Instituto de salud Carlos III PI13/00061 to Granada, PI13/ 01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236), Navarra and Catalonia (Catalan Institute of Oncology – ICO-IDIBELL) (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), and Cancer Research UK (C864/A14136 to EPIC-Norfolk and C8221/A19170 to EPICOxford), Medical Research Council (MR/N003284/1 and MC-UU_12015/1 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford) (United Kingdom). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Open Access funding enabled and organized by Projekt DEAL.
Subjects: Male, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings], lcsh:Medicine, Cancer prevention, Cohort Studies, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Calibration [Medical Subject Headings], 0302 clinical medicine, Risk Factors, Neoplasias colorrectales, Medicine, 030212 general & internal medicine, Prospective Studies, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings], 10. No inequality, Prospective cohort study, 11 Medical and Health Sciences, Framingham Risk Score, Risk screening, Lifestyle behaviour, Risk prediction, Colorectal cancer, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, 030220 oncology & carcinogenesis, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings], Female, Risk assessment, Colorectal Neoplasms, Research Article, Cohort study, Estils de vida, Waist, Lifestyles, Nutritional Status, Check Tags::Male [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Estil de vida, Risk Assessment, Riesgo, Estilo de vida, 03 medical and health sciences, Càncer colorectal, General & Internal Medicine, Humans, Life Style, business.industry, lcsh:R, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Probability::Risk [Medical Subject Headings], Technology and Food and Beverages::Food and Beverages::Food::Vegetables [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style [Medical Subject Headings], Nomogram, Lifestyle, Diet, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Check Tags::Female [Medical Subject Headings], Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], business, Prevención de Enfermedades, Demography
Abstract: Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). Conclusions: LiFeCRC score based on age and lifestyle data accurately identifies individuals at risk for incident colorectal cancer in European populations and could contribute to improved prevention through motivating lifestyle change at an individual level., German Research Foundation (DFG) AL 1784/3-1, European Commission European Commission Joint Research Centre, International Agency for Research on Cancer, Danish Cancer Society, Ligue Contre le Cancer (France), Institut Gustave Roussy (France), Mutuelle Generale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) (Germany), Federal Ministry of Education & Research (BMBF), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro (AIRC), Consiglio Nazionale delle Ricerche (CNR), Netherlands Government, World Cancer Research Fund International (WCRF), Instituto de Salud Carlos III PI13/00061 PI13/01162, Junta de Andalucia, Regional Government of Asturias (Spain), Regional Government of Basque Country (Spain), Regional Government of Murcia (Spain) 6236, Regional Government of Navarra (Spain), Regional Government of Catalonia (Catalan Institute of Oncology -ICO-IDIBELL) (Spain), Swedish Cancer Society, Swedish Research Council, County Council of Skane (Sweden), County Council of Vasterbotten (Sweden), Cancer Research UK C864/A14136 C8221/A19170, UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MR/N003284/1 MC-UU_12015/1 MR/M012190/1, Projekt DEAL
Published: 2021
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14. Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin

Author: Guenievre Roussel, Bruno Lebrun, Vincent Prevot, Michel Dallaporta, Marie-Christine Tonon, Damien Lanfray, André Jean, Manon Duquenne, Florent Guillebaud, Jean-Denis Troadec, Seddik Riad, Mehdi Djelloul, Jérôme Leprince, Clément Pierre, Kevin Poirot, Stéphanie Gaigé, Fabrice Morin, Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cell Stem Cell Laboratory for CNS Disease Modeling, Physiologie et physiopathologie du système nerveux somato-moteur et neurovégétatif (PPSN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lille Neurosciences & Cognition - U 1172 (LilNCog), Lund Stem Cell Center, Lund University [Lund]-Lund University [Lund], and ANR-16-CE14-0011,EZICROM,Rôle des endozépines dans la régulation centrale normale et pathologique du métabolisme énergétique(2016)
Subjects: 0301 basic medicine, MAPK/ERK pathway, medicine.medical_specialty, Endozepine, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.medical_treatment, Neuroscience (miscellaneous), Context (language use), [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, Biology, Energy homeostasis, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, Leptin receptor, [SCCO.NEUR]Cognitive science/Neuroscience, Insulin, Leptin, digestive, oral, and skin physiology, 030104 developmental biology, Endocrinology, Neurology, chemistry, Hypothalamus, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: Research on energy homeostasis has focused on neuronal signaling; however, the role of glial cells has remained little explored. Glial endozepines exert anorexigenic actions by mechanisms which remain poorly understood. In this context, the present study was designed to decipher the mechanisms underlying the anorexigenic action of endozepines and to investigate their potential curative effect on high-fat diet-induced obesity. We carried out a combination of physiological, pharmacological, and molecular analyses together to dissect the underlying mechanisms of endozepine-induced hypophagia. To evaluate the potential anti-obesity effect of endozepines, different model of obesity were used, i.e., ob/ob and diet-induced obese mice. We show that the intracerebral administration of endozepines enhances satiety by targeting anorexigenic brain circuitry and induces STAT3 phosphorylation, a hallmark of leptin signaling. Strikingly, endozepines are entirely ineffective at reducing food intake in the presence of a circulating leptin antagonist and in leptin-deficient mice (ob/ob) but potentiate the reduced food intake and weight loss induced by exogenous leptin administration in these animals. Endozepines reversed high fat diet-induced obesity by reducing food intake and restored leptin-induced STAT3 phosphorylation in the hypothalamus. Interestingly, we observed that glucose and insulin synergistically enhance tanycytic endozepine expression and release. Finally, endozepines, which induce ERK activation necessary for leptin transport into the brain in cultured tanycytes, require tanycytic leptin receptor expression to promote STAT3 phosphorylation in the hypothalamus. Our data identify endozepines as potential anti-obesity compounds in part through the modulation of the LepR-ERK-dependent tanycytic leptin shuttle.
Published: 2020
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15. Big Data Palaeoecology reveals significant variation in Black Death mortality in Europe [Preprint]

Author: Izdebski, A., Guzowski, P., Poniat, R., Masci, L., Palli, J., Vignola, C., Bauch, M., Cocozza, C., Fernandes, R., Ljungqvist, F. C., Newfield, T., Seim, A., Abel-Schaad, D., Alba-Sánchez, F., Björkman, L., Brauer, A., Brown, A., Czerwiński, S., Ejarque, A., Fiłoc, M., Florenzano, A., Fredh, E. D., Fyfe, R., Jasiunas, N., Kołaczek, P., Kouli, K., 1, Kozáková, R., Kupryjanowicz, M., Lagerås, P., Lamentowicz, M., Lindbladh, M., López-Sáez, J. A., Luelmo-Lautenschlaeger, R., Marcisz, K., Mazier, F., Mensing, S., Mercuri, A. M., Milecka, K., Miras, Y., Noryśkiewicz, A. M., Novenko, E., Obremska, M., Panajiotidis, S., Papadopoulou, M. L., Pędziszewska, A., Pérez-Díaz, S., Piovesan, G., Pluskowski, A., Pokorny, P., Poska, A., Reitalu, T., Rösch, M., Sadori, L., Sá Ferreira, C., Sebag, D., Słowiński, M., Stančikaitė, M., Stivrins, N., Tunno, I., Veski, S., Wacnik, A., Masi, A., Universidad de Cantabria, Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Bialystok, Department of Earth Sciences, Sapienza University of Rome, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Environmental Biology, Sapienza University of Rome, Università degli studi della Tuscia [Viterbo], Leibniz Institute for the History and Culture of Eastern Europe (GWZO), Universität Leipzig, ArchaeoBioCenter, Ludwig-Maximilians-Universität München, München, Germany, School of Archaeology, University of Oxford, Oxford, UK, Masaryk University [Brno] (MUNI), Stockholm University, Bolin Centre for Climate Research, Swedish Collegium for Advanced Study [Uppsala], Department of History, Georgetown University, Washington DC, USA, Department of biology, georgetown University, Washington DC, Chair of Forest Growth and Dendroecology, University of Freiburg, Institute of Botany [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, Universidad de Granada = University of Granada (UGR), Viscum Pollenanalys & Miljöhistoria, Nässjö, Sweden, German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Institute of Geosciences [Potsdam], University of Potsdam = Universität Potsdam, Wessex Archaeology [Salisbury], Department of Archaeology and Centre for Past Climate Change, University of Reading, Reading, UK, Adam Mickiewicz University in Poznań (UAM), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Department of Palaeobiology, Faculty of Biology, University of Białystok, Białystok, Poland, Laboratory of Palynology and Palaeobotany, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy, The Arctic University of Norway [Tromsø, Norway] (UiT), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, University of Latvia (LU), National and Kapodistrian University of Athens (NKUA), Institute of Archaeology of the Czech Academy of Sciences, Prague, The Archaeologists, National Historical Museums, Lund, Sweden, Southern Swedish Forest Research Centre, Swedish University of Agricultural Sciences (SLU), Environmental Archaeology Research Group, Institute of History, CSIC, Madrid, Spain, Department of Geography, Universidad Autónoma de Madrid, Madrid, Spain, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Geography, University of Nevada, Reno, USA, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Nicolaus Copernicus University [Toruń], MSU Faculty of Geography [Moscow], Lomonosov Moscow State University (MSU), Institute of Geography, Russian Academy of Sciences, Moscow, Russian Federation, Institute of Geological Sciences, Polish Academy of Sciences, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Laboratory of Forest Botany-Geobotany, School of Forestry and Natural Environment, Aristotle University of Thessaloniki, Thessaloniki, Greece, University of Cologne, Faculty of Biology [Gdansk, Poland], University of Gdańsk (UG), Department of Geography, Urban and Regional Planning, Universidad de Cantabria, Santander, Spain., Centre for Theoretical Studies, Charles University, Czechia (CTS), Charles University [Prague] (CU)-Czech Academy of Sciences [Prague] (CAS), Institute of Geology at Tallinn, Tallinn University of Technology (TTÜ), Universität Heidelberg [Heidelberg] = Heidelberg University, Queen's University [Belfast] (QUB), IFP Energies nouvelles (IFPEN), Institute of Geography and Spatial Organization, Polish Academy of Sciences, Nature Research Centre, Institute of Geology and Geography, Vilnius, Lithuania, Center for Accelerator Mass Spectrometry (CAMS), Lawrence Livermore National Laboratory, Lawrence, CA, USA, W. Szafer Institute of Botany, Polish Academy of Sciences, European Project: 263735,EC:FP7:ERC,ERC-2010-StG_20091209,TEC(2010), Max Planck Institute for the Science of Human History, Kahlaische Str. 10, 07745, Jena, Germany, Faculty of History and International Relations, University of Bialystok, Bialystok, Poland, Department of Earth Science, Sapienza University of Rome, Rome, Italy, Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy, Leibniz Institute for the History and Culture of Eastern Europe (GWZO), Leipzig, Germany, Swedish Collegium for Advanced Study, Uppsala, Sweden, Chair of Forest Growth and Dendroecology, Institute of Forest Sciences, Albert-Ludwigs-University Freiburg, Freiburg, Universität Innsbruck [Innsbruck], GFZ-German Research Centre for Geosciences, Section Climate Dynamics and Landscape Evolution, Potsdam, Germany, Institute of Geosciences, University of Potsdam, Potsdam, Germany, Wessex Archaeology, Portway House, Salisbury, UK, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), The Arctic University of Norway (UiT), Institute of Archeology, Academy of Sciences of the Czech Republic, Prague, Czech Republi, Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Faculty of Geography, Lomonosov Moscow State University, Moscow, Russia., Department of Quaternary Research, Institute of Geography Russian Academy of Science, Moscow, Russia, Institute of Geological Sciences, Polish Academy of Sciences, Warsaw, Poland., Laboratory of Palaeoecology and Archaeobotany, Department of Plant Ecology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland., Charles University [Prague] (CU), Department of Geology, Tallinn University of Technology, Tallinn, Estonia, Lund University [Lund], Department of Geology, Tallinn University of Technology, Tallinn, Estonia., Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia, University of Tartu, Universität Heidelberg [Heidelberg], IFP Energies Nouvelles, Earth Sciences and Environmental Technologies Division, Rueil-Malmaison, Rueil-Malmaison, Past Landscape Dynamics Laboratory, Institute of Geography and Spatial Organization, Polish Academy of Sciences, Warsaw, Poland., 3 Department of Geology, Tallinn University of Technology, Tallinn, Estonia, W. Szafer Institute of Botany, Polish Academy of Sciences, Kraków, Poland., Institute of History, Jagiellonian University in Krakow, Krakow, Poland, Department of Agriculture and Forest Sciences (Dafne), University of Tuscia, Viterbo, Italy, Department of Ecological and Biological Sciences (Deb), University of Tuscia, Viterbo, Italy., Faculty of Arts, Masaryk University, Brno, Czech Republic, Department of Botany, University of Innsbruck, Innsbruck, Austria, Department of Botany, University of Granada, Granada, Spain, Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland., Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), ISEM, UMR 5554, Université Montpellier, CNRS, EPHE, IRD, Montpellier, Museum of Archaeology, University of Stavanger, Stavanger, Norway, School of Geography, Earth and Environmental Science, University of Plymouth, Plymouth, UK, Department of Geography, University of Latvia, Riga, Latvia., Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland, Department of Geology and Geoenvironment, National and Kapodistrian University of Athens, Athens, Greece, Southern Swedish Forest Research Centre, Swedish University of Agricultural Sciences, Alnarp, Sweden, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Anthropocene Research Unit, Faculty of Geographical and Geological Sciences, Adam Mickiewicz University, Poznań, CNRS, HNHP UMR 7194, Muséum National d’Histoire Naturelle, Institut de Paléontologie Humaine, Paris, France, Institute of Archaeology, Faculty of History, Nicolaus Copernicus University, Toruń, Poland., Centre for Climate Change Research, Nicolaus Copernicus University, Toruń, Poland, Institute of Geography, University of Cologne, Cologne, Germany, Department of Ecological and Biological Sciences (Deb), University of Tuscia, Viterbo, Italy, Centre for Theoretical Study, Charles University and Academy of Sciences of the Czech Republic, Prague, Czech Republic., Department of Physical Geography and Ecosystem Science, Lund University, Lund, Sweden, Department of Pre- and Early History and West Asian Archaeology, University of Heidelberg, Heidelberg, Germany, School of Natural and Built Environment, Queen’s University, Belfast, Northern Ireland, Department of Geography, University of Latvia, Riga, Latvia, Institute of Latvian History, University of Latvia, Riga, Latvia., Max Planck Society, Estonian Research Council, European Research Council, Latvian Council of Science, Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Swedish Research Council, Volkswagen Foundation, Ministerio de Ciencia e Innovación (España), López Sáez, José Antonio [0000-0002-3122-2744], López Sáez, José Antonio, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)
Subjects: Land-use changes, Ecology, black death pandemic, Humaniora: 000::Arkeologi: 090 [VDP], palaeoecological data, [SHS.GEO]Humanities and Social Sciences/Geography, paleoecology, palynology, big data, paleoecology, Europe, big data, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SDE]Environmental Sciences, [SHS.HIST]Humanities and Social Sciences/History, palynology, Ecology, Evolution, Behavior and Systematics
Abstract: The authors acknowledge the following funding sources: Max Planck Independent Research Group, Palaeo-Science and History Group (A.I., A.M. and C.V.); Estonian Research Council #PRG323, PUT1173 (A.Pos., T.R., N.S. and S.V.); European Research Council #FP7 263735 (A.Bro. and A.Plu.), #MSC 655659 (A.E.); Georgetown Environmental Initiative (T.N.); Latvian Council of Science #LZP-2020/2-0060 (N.S. and N.J.); LLNL-JRNL-820941 (I.T.); NSF award #GSS-1228126 (S.M.); Polish-Swiss Research Programme #013/2010 CLIMPEAT (M.Lam.), #086/2010 CLIMPOL (A.W.); Polish Ministry of Science and Higher Education #N N306 275635 (M.K.); Polish National Science Centre #2019/03/X/ST10/00849 (M.Lam.), #2015/17/B/ST10/01656 (M.Lam.), #2015/17/B/ST10/03430 (M.So.), #2018/31/B/ST10/02498 (M.So.), #N N304 319636 (A.W.); SCIEX #12.286 (K.Mar.); Spanish Ministry of Economy and Competitiveness #REDISCO-HAR2017-88035-P (J.A.L.S.); Spanish Ministry of Education, Culture and Sports #FPU16/00676 (R.L.L.); Swedish Research Council #421-2010-1570 (P.L.), #2018-01272 (F.C.L. and A.S.); Volkswagen Foundation Freigeist Fellowship Dantean Anomaly (M.B.), Spanish Ministry of Science and Innovation #RTI2018-101714-B-I00 (F.A.S. and D.A.S.), OP RDE, MEYS project #CZ.02.1.01/0.0/0.0/16_019/0000728 (P.P.)., The Black Death (1347–1352 ce) is the most renowned pandemic in human history, believed by many to have killed half of Europe’s population. However, despite advances in ancient DNA research that conclusively identified the pandemic’s causative agent (bacterium Yersinia pestis), our knowledge of the Black Death remains limited, based primarily on qualitative remarks in medieval written sources available for some areas of Western Europe. Here, we remedy this situation by applying a pioneering new approach, ‘big data palaeoecology’, which, starting from palynological data, evaluates the scale of the Black Death’s mortality on a regional scale across Europe. We collected pollen data on landscape change from 261 radiocarbon-dated coring sites (lakes and wetlands) located across 19 modern-day European countries. We used two independent methods of analysis to evaluate whether the changes we see in the landscape at the time of the Black Death agree with the hypothesis that a large portion of the population, upwards of half, died within a few years in the 21 historical regions we studied. While we can confirm that the Black Death had a devastating impact in some regions, we found that it had negligible or no impact in others. These inter-regional differences in the Black Death’s mortality across Europe demonstrate the significance of cultural, ecological, economic, societal and climatic factors that mediated the dissemination and impact of the disease. The complex interplay of these factors, along with the historical ecology of plague, should be a focus of future research on historical pandemics., Max Planck Independent Research Group, Palaeo-Science and History Group, Estonian Research Council PRG323 PUT1173, European Research Council (ERC) European Commission FP7 263735 MSC 655659, Georgetown Environmental Initiative, Latvian Ministry of Education and Science LZP-2020/2-0060 LLNL-JRNL-820941, National Science Foundation (NSF) GSS-1228126, Polish-Swiss Research Programme 013/2010 086/2010, Ministry of Science and Higher Education, Poland N306 275635, Polish National Science Centre 2019/03/X/ST10/00849 2015/17/B/ST10/01656 2015/17/B/ST10/03430 2018/31/B/ST10/02498 N N304 319636, SCIEX 12.286, Spanish Government REDISCO-HAR2017-88035-P FPU16/00676, Swedish Research Council, European Commission 421-2010-1570 2018-01272, Volkswagen Foundation Freigeist Fellowship Dantean Anomaly, Spanish Government RTI2018-101714-B-I00, OP RDE, MEYS project CZ.02.1.01/0.0/0.0/16_019/0000728
Published: 2022
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16. Measuring, comparing and interpreting phenotypic selection on floral scent

Author: Øystein H. Opedal, Karin Gross, Elodie Chapurlat, Amy Parachnowitsch, Nina Joffard, Nina Sletvold, Otso Ovaskainen, Magne Friberg, Biosciences, Organismal and Evolutionary Biology Research Programme, Otso Ovaskainen / Principal Investigator, Department of Agricultural Sciences, Department of Biology, Lund University, Lund, Sweden, Lund University [Lund], Paris Lodron University of Salzburg - Department of Environment and Biodiversity, Uppsala University, Swedish University of Agricultural Sciences (SLU), University of New Brunswick, Fredericton, Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP)), Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Jyväskylä (JYU), Organismal and Evolutionary Biology [Helsinki], Viikki Plant Science Centre (ViPS), Faculty of Biological and Environmental Sciences [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Biological and Environmental Sciences [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Department of Biology [Trondheim] (IBI NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), and Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU)
Subjects: reduced-rank regression, Flowers, NURSERY POLLINATION, PREFERENCES, ECOLOGY, selection gradient, kukat (kasvit), Pheromones, PRIVATE CHANNEL, CHEMISTRY, kasvit, Animals, Pollination, pölyttäjät, Ecology, Evolution, Behavior and Systematics, Ekologi, floral scent, Volatile Organic Compounds, Evolutionary Biology, SMELL, plant–pollinator interactions, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], luonnonvalinta, Ecology, tuoksu, natural selection, EVOLUTION, NATURAL-SELECTION, Phenotype, floral fragrance, POLLINATOR ATTRACTION, Odorants, 1181 Ecology, evolutionary biology, TRAITS, plant-pollinator interactions
Abstract: Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointly estimate a scent composite trait under selection and the strength of selection acting on this trait. To assess and compare variation in selection on scent across species, time and space, we reanalyse 22 datasets on six species from four previous studies. The results agreed qualitatively with previous analyses in terms of identifying populations and scent compounds subject to stronger selection but also allowed us to evaluate and compare the strength of selection on scent across studies. Doing so revealed that selection on floral scent was highly variable, and overall about as common and as strong as selection on other phenotypic traits involved in pollinator attraction or pollen transfer. These results are consistent with an important role of floral scent in pollinator attraction. Our approach should be useful for further studies of plant-animal communication and for studies of selection on other high-dimensional phenotypes. In particular, our approach will be useful for studies of pollinator-mediated selection on complex scent blends comprising many volatiles, and when no prior information on the physiological responses of pollinators to scent compounds is available.
Published: 2022
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17. Fracture behavior of a composite of bone and calcium sulfate/hydroxyapatite

Author: Joeri Kok, Elin Törnquist, Deepak Bushan Raina, Sophie Le Cann, Vladimir Novak, Aurimas Širka, Lars Lidgren, Lorenzo Grassi, Hanna Isaksson, Lund University [Lund], Laboratoire Modélisation et Simulation Multi-Echelle (MSME), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, The Swiss Light Source (SLS) (SLS-PSI), Paul Scherrer Institute (PSI), Lithuanian University of Health Sciences [Kaunas, Lithuania], Swiss Light Source, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen, Lithuania University of Health Science, A.Mickeviciaus ave.2, Kaunas, Department of Biomedical Engineering, Lund University, 22100 Lund, Sweden, Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden, and LE CANN, Sophie
Subjects: [SPI] Engineering Sciences [physics], Sulfates, Biomedical Engineering, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Biocompatible Materials, Calcium Sulfate, Bone and Bones, Biomaterials, [SPI]Engineering Sciences [physics], Fractures, Bone, Durapatite, Mechanics of Materials, Humans, ComputingMilieux_MISCELLANEOUS
Abstract: Calcium sulfate/hydroxyapatite (CaS/HA) biomaterials have been investigated for use in several orthopedic applications. However, the mechanical interactions between the composite of CaS/HA and bone at the microscale are still unknown. The aim of this study was to determine if and how augmentation with CaS/HA alters the fracture behavior of bone. Eleven cylinders of trabecular bone were drilled from human femoral heads and cleaned from bone marrow. Among them, five cylinders were injected with CaS/HA to generate composite specimens, while the others were kept intact. One extra specimen of pure CaS/HA was prepared. All specimens were compressed in situ using synchrotron X-ray tomography and imaged at ∼2% strain intervals. Structural properties were calculated from the images in unloaded state and mechanical properties were determined from the load-curves. CaS/HA alone displayed the highest peak force and stiffness and the lowest strain at fracture. All composite specimens had a higher peak force than the pure bone specimens and the composite specimens had higher toughness than the pure CaS/HA specimen. Furthermore, the fracture behavior was analyzed further to characterize the local deformations. The pure bone specimens presented damage in multiple trabeculae and the CaS/HA specimen displayed sharp transition in strains, with low strain in one load step and large cracks in the next. The composite specimens deformed uniformly, with the CaS/HA preventing tissue damage and the bone preventing cracks in the CaS/HA from propagating through the specimen. In conclusion, using tomography with in situ loading, it was possible to show how CaS/HA can help prevent bone tissue damage before global failure.
Published: 2021
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18. Dual modality neutron and x-ray tomography for enhanced image analysis of the bone-metal interface

Author: Deepak Bushan Raina, Nicolas Lenoir, Johan Hektor, Stephen Hall, Hanna Isaksson, Alessandro Tengattini, Edward Andò, Magnus Tägil, Sophie Le Cann, Elin Törnquist, Erika Tudisco, Lund University [Lund], Laboratoire Modélisation et Simulation Multi-Echelle (MSME), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Institut Laue-Langevin (ILL), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Lund Institute of Advanced Neutron and X-ray Science (LINXS) , Lund, Sweden, Department of Biomedical Engineering, Lund University, 22100 Lund, Sweden, Division of Geotechnical Engineering, Lund University, Sweden, ILL, LUNARC — Centre for Scienti ﬁ c and Technical Computing at Lund University, Lund University, Lund, Sweden, Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden, and Division of Solid Mechanics, Lund University, Sweden
Subjects: Materials science, Image registration, 030209 endocrinology & metabolism, Bone tissue, Bone and Bones, 03 medical and health sciences, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Histogram, Image Processing, Computer-Assisted, medicine, Animals, Radiology, Nuclear Medicine and imaging, Segmentation, Neutron, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Neutrons, 0303 health sciences, Radiological and Ultrasound Technology, Neutron tomography, Rats, medicine.anatomical_structure, Metals, Implant, Tomography, Tomography, X-Ray Computed, Biomedical engineering
Abstract: The bone tissue formed at the contact interface with metallic implants, particularly its 3D microstructure, plays a pivotal role for the structural integrity of implant fixation. X-ray tomography is the classical imaging technique used for accessing microstructural information from bone tissue. However, neutron tomography has shown promise for visualising the immediate bone-metal implant interface, something which is highly challenging with x-rays due to large differences in attenuation between metal and biological tissue causing image artefacts. To highlight and explore the complementary nature of neutron and x-ray tomography, proximal rat tibiae with titanium-based implants were imaged with both modalities. The two techniques were compared in terms of visualisation of different material phases and by comparing the properties of the individual images, such as the contrast-to-noise ratio. After superimposing the images using a dedicated image registration algorithm, the complementarity was further investigated via analysis of the dual modality histogram, joining the neutron and x-ray data. From these joint histograms, peaks with well-defined grey value intervals corresponding to the different material phases observed in the specimens were identified and compared. The results highlight differences in how neutrons and x-rays interact with biological tissues and metallic implants, as well as the benefits of combining both modalities. Future refinement of the joint histogram analysis could improve the segmentation of structures and tissues, and yield novel information about specimen-specific properties such as moisture content.
Published: 2021
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19. 3D X-ray tomographic analysis reveals how coesite is preserved in Muong Nong-type tektites

Author: Stefano Peres, Sounthone Singsoupho, Pierre Rochette, F. Campanale, Matteo Masotta, Nicolas Gueninchault, Luigi Folco, Billy P. Glass, Francesco Radica, Lucia Mancini, Enrique Navarro, University of Pisa - Università di Pisa, XRD2 beamline, Elettra - Sincrotrone Trieste S.C.p.A., Strada Statale 14- km 163,5 in AREA Science Park, 34149 Basovizza, Trieste, Italy, Lund University [Lund], Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Delaware [Newark], Zeiss Research Microscopy Solutions, Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), National University of Laos, Universidad Nacional Autónoma de Managua [Nicaragua], Lund Institute of advanced Neutron and X-ray Science (LINXS), Lund University, Lund, Sweden, Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Università degli Studi Roma Tre, Masotta, M, Peres, S, Folco, L, Mancini, L, Rochette, P, Glass, B, Campanale, F, Gueninchault, N, Radica, F, Singsoupho, S, and Navarro, E
Subjects: Materials science, 010504 meteorology & atmospheric sciences, Nucleation, Mineralogy, lcsh:Medicine, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, Strewn field, Article, Coesite, lcsh:Science, Quartz, 0105 earth and related environmental sciences, Multidisciplinary, Tektite, Vesicle, lcsh:R, Meteoritics, engineering, Muong Nong‐type tektites, ctesite survival, x-ray tomography, lcsh:Q, Inclusion (mineral), Earth (classical element)
Abstract: Muong Nong-type (MN) tektites are a layered type of tektite associated to the Australasian strewn field, the youngest (790 kyr) and largest on Earth. In some MN tektites, coesite is observed in association with relict quartz and silica glass within inclusions surrounded by a froth layer. The formation of coesite-bearing frothy inclusions is here investigated through a 3D textural multiscale analysis of the vesicles contained in a MN tektite sample, combined with compositional and spectroscopic data. The vesicle size distribution testifies to a post-shock decompression that induced melting and extensive vesiculation in the tektite melt. Compared to free vesicles, nucleated homogeneously in the tektite melt, froth vesicles nucleated heterogeneously on relict quartz surfaces at the margins of coesite-bearing inclusions. The rapid detachment of the froth vesicles and prompt reactivation of the nucleation site favoured the packing of vesicles and the formation of the froth structure. Vesicle relaxation time scales suggest that the vesiculation process lasted few seconds. The formation of the froth layer was instrumental for the preservation of coesite, promoting quenching of the inclusion core through the subtraction of heat during froth expansion, thereby physically insulating the inclusion until the final quench of the tektite melt.
Published: 2020
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20. A Review of Terminology Used to Describe Soot Formation and Evolution under Combustion and Pyrolytic Conditions

Author: Hai Wang, J. Houston Miller, Brian S. Haynes, Pascale Desgroux, Meredith B. Colket, Per-Erik Bengtsson, Hope A. Michelsen, Andrea D’Anna, Heinz Pitsch, Graham J. Nathan, Department of Combustion Physics, Lund Institute of Technology, Lund University [Lund]-Lund University [Lund], Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522 (PC2A), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Michelsen, H. A., Colket, M. B., Bengtsson, P. -E., D'Anna, A., Desgroux, P., Haynes, B. S., Miller, J. H., Nathan, G. J., Pitsch, H., and Wang, H.
Subjects: Glossary, Computer science, General Physics and Astronomy, Particle, 02 engineering and technology, 010402 general chemistry, medicine.disease_cause, Combustion, 01 natural sciences, Terminology, Aggregation, [SPI]Engineering Sciences [physics], Lead (geology), Soot, medicine, Incipient, General Materials Science, Brown carbon, ComputingMilieux_MISCELLANEOUS, Confusion, Particulate, Agglomeration, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, General Engineering, Carbonization, 021001 nanoscience & nanotechnology, Data science, 0104 chemical sciences, Inception, Nucleation, medicine.symptom, 0210 nano-technology, Nascent
Abstract: This review presents a glossary and review of terminology used to describe the chemical and physical processes involved in soot formation and evolution and is intended to aid in communication within the field and across disciplines. There are large gaps in our understanding of soot formation and evolution and inconsistencies in the language used to describe the associated mechanisms. These inconsistencies lead to confusion within the field and hinder progress in addressing the gaps in our understanding. This review provides a list of definitions of terms and presents a description of their historical usage. It also addresses the inconsistencies in the use of terminology in order to dispel confusion and facilitate the advancement of our understanding of soot chemistry and particle characteristics. The intended audience includes senior and junior members of the soot, black carbon, brown carbon, and carbon black scientific communities, researchers new to the field, and scientists and engineers in associated fields with an interest in carbonaceous material production via hightemperature hydrocarbon chemistry. © 2020 American Chemical Society.
Published: 2020
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21. Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider

Author: Garcia-Revilla, Juan, Deierborg, Tomas, Venero, Jose Luis, Boza-Serrano, Antonio, [Garcia-Revilla,J, Venero,JL, Boza-Serrano,A] Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Deierborg,T] Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, BMC, Lund University, Lund, Sweden. [Boza-Serrano,A] Department of Experimental Medical Sciences, Experimental Dementia Research Laboratory, BMC, Lund University, Lund, Sweden., This work was supported by grants from the Swedish Research Council (2019-06333, AB-S), and the Strong Research Environment MultiPark (Multidisciplinary Research in Parkinson’s and Alzheimer’s Disease at Lund University), Bagadilico (Linné consortium sponsored by the Swedish Research Council), the Swedish Alzheimer’s Foundation, Swedish Brain Foundation, A.E. Berger Foundation, Gyllenstiern-ska Krapperup Foundation, the Royal Physiographic Society, Crafoord Foundation, Olle Engkvist Byggmästare Foundation, Wiberg Foundation, G&J Kock Foundation, Stohnes Foundation, and Swedish Dementia Association and the Medical Faculty at Lund University. This perspective was also funded by the Spanish Ministerio de Ciencia, Innovación y Universidades/FEDER/UE RTI2018-098645-B-100, FEDER I+D+i-USE US-1265062, and US-1264806. JG-R has been funded by a grant from the Spanish Ministerio de Economia y Competitividad SAF2015-64171-R (MINECO/FEDER, EU)., Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Swedish Research Council, Lund University, Swedish Alzheimer Foundation, Swedish Brain Foundation, Royal Physiographic Society of Lund, Crafoord Foundation, Olle Engkvist Foundation, Ake Wiberg Foundation, Gun and Bertil Stohnes Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, and Ministerio de Economía y Competitividad (España)
Subjects: Galectina 3, Galectin 3, Galectins, Pulmonary Fibrosis, Infecciones por coronavirus, Immunology, Pneumonia, Viral, Peptidyl-Dipeptidase A, Cytokine storm, Severity of Illness Index, Betacoronavirus, Animals, Humans, Galectin-3, Molecular Targeted Therapy, Diseases::Respiratory Tract Diseases::Lung Diseases::Pulmonary Fibrosis [Medical Subject Headings], Pandemics, Inflammation, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines [Medical Subject Headings], Inflamación, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Galectins::Galectin 3 [Medical Subject Headings], SARS-CoV-2, COVID-19, Citocinas, Blood Proteins, Biomarker, Prognosis, Fibrosis, Diseases::Respiratory Tract Diseases::Lung Diseases::Pneumonia [Medical Subject Headings], Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Perspective, Host-Pathogen Interactions, Spike Glycoprotein, Coronavirus, Disease Progression, biomarker, Cytokines, Angiotensin-Converting Enzyme 2, Biomarcadores ambientales, Coronavirus Infections, Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Biomarkers
Abstract: COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach., This work was supported by grants from the Swedish Research Council (2019-06333, AB-S), and the Strong Research Environment MultiPark (Multidisciplinary Research in Parkinson’s and Alzheimer’s Disease at Lund University), Bagadilico (Linné consortium sponsored by the Swedish Research Council), the Swedish Alzheimer’s Foundation, Swedish Brain Foundation, A.E. Berger Foundation, Gyllenstiern-ska Krapperup Foundation, the Royal Physiographic Society, Crafoord Foundation, Olle Engkvist Byggmästare Foundation, Wiberg Foundation, G&J Kock Foundation, Stohnes Foundation, and Swedish Dementia Association and the Medical Faculty at Lund University. This perspective was also funded by the Spanish Ministerio de Ciencia, Innovación y Universidades/FEDER/UE RTI2018-098645-B-100, FEDER ICDCi-USE US-1265062, and US-1264806. JG-R has been funded by a grant from the Spanish Ministerio de Economia y Competitividad SAF2015-64171-R (MINECO/FEDER, EU).
Published: 2020

22. Bone Damage Evolution Around Integrated Metal Screws Using X-Ray Tomography — in situ Pullout and Digital Volume Correlation

Author: Le Cann, Sophie, Tudisco, Erika, Tägil, Magnus, Hall, Stephen, Isaksson, Hanna, Department of Biomedical Engineering, Lund University, 22100 Lund, Sweden, Division of Geotechnical Engineering, Lund University, Sweden, Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden, Division of Solid Mechanics, Lund University, Sweden, and Lund Institute of advanced Neutron and X-ray Science (LINXS), Lund University, Lund, Sweden
Subjects: Histology, [SDV]Life Sciences [q-bio], Biomedical Engineering, Bioengineering and Biotechnology, Bioengineering, metallic screw, bone, [SPI]Engineering Sciences [physics], Digital Volume Correlation, X-ray tomography, in situ loading, ComputingMilieux_MISCELLANEOUS, Original Research, Biotechnology
Abstract: Better understanding of the local deformation of the bone network around metallic implants subjected to loading is of importance to assess the mechanical resistance of the bone-implant interface and limit implant failure. In this study, four titanium screws were osseointegrated into rat tibiae for 4 weeks and screw pullout was conducted in situ under x-ray microtomography, recording macroscopic mechanical behavior and full tomographies at multiple load steps before failure. Images were analyzed using Digital Volume Correlation (DVC) to access internal displacement and deformation fields during loading. A repeatable failure pattern was observed, where a ∼300–500 μm-thick envelope of bone detached from the trabecular structure. Fracture initiated close to the screw tip and propagated along the implant surface, at a distance of around 500 μm. Thus, the fracture pattern appeared to be influenced by the microstructure of the bone formed closely around the threads, which confirmed that the model is relevant for evaluating the effect of pharmacological treatments affecting local bone formation. Moreover, cracks at the tibial plateau were identified by DVC analysis of the tomographic images acquired during loading. Moderate strains were first distributed in the trabecular bone, which localized into higher strains regions with subsequent loading, revealing crack-formation not evident in the tomographic images. The in situ loading methodology followed by DVC is shown to be a powerful tool to study internal deformation and fracture behavior of the newly formed bone close to an implant when subjected to loading. A better understanding of the interface failure may help improve the outcome of surgical implants.
Published: 2020
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23. Heat flux reconstruction by inversion of experimental infrared temperature measurements – Application to the impact of a droplet in the film boiling regime

Author: Jean-François Pierson, Guillaume Castanet, Ophélie Caballina, William Chaze, Fabrice Lemoine, Denis Maillet, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Division of Combustion Physics, Lund Institute of Technology, Lund University [Lund]-Lund University [Lund], Institut Jean Lamour (IJL), and Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Fluid Flow and Transfer Processes, Materials science, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, Mechanical Engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Thermal conduction, 01 natural sciences, Temperature measurement, Leidenfrost effect, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 010305 fluids & plasmas, Drop impact, Physics::Fluid Dynamics, Boiling point, Heat flux, 0103 physical sciences, Heat transfer, Thermal, [SPI.MECA.THER]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Thermics [physics.class-ph], Composite material, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: An Inverse Heat Conduction Problem (IHCP) is considered in order to estimate the transient heat flux extracted from a hot solid surface by an impinging droplet. The resolution of the IHCP is made with the so-called quadrupole method, which provides an analytical expression of the temperature and the heat flux at the front surface of the solid wall, where the drop impact takes place. In the experiments, the thermal response of the front surface is recorded using IR thermography. For that, sapphire is chosen as the material of the solid wall, and the front surface is coated with a thin TiAlN ceramic layer (thickness of 300 nm). The latter is highly emissive and opaque in the IR while sapphire is transparent at the same wavelengths. This feature allows the surface impacted by the droplet to be viewed from the bottom by the IR camera. This approach has been implemented to gain some insights into the heat transfer from the solid surface as well as the formation and growth of the vapor film, which appears under the droplet in the regime of film boiling, when the solid temperature is much higher than the boiling temperature of the liquid. Due to the small thickness of the vapor film, heat conduction is predominant in the vapor layer. Hence, the thickness of the vapor film can be deduced from the value of the reconstructed local heat flux, assuming a linear profile of temperature between the liquid interface of the droplet at the saturation temperature and the solid surface measured by IR thermometry.
Published: 2019
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24. Resting metabolic rate in migratory and non-migratory geese following range expansion; go south, go low

Author: Dennis Hasselquist, Manfred R. Enstipp, Götz Eichhorn, Jean-Yves Georges, Bart A. Nolet, Department of Animal Ecology (NIOO-KNAW), Netherlands Institute of Ecology (NIOO-KNAW), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Biology, Lund University, Lund, Sweden, Lund University [Lund, Sweden], Theoretical and computational Ecology, University of Amsterdam, Dutch Centre for Avian Migration & Demography, Animal Ecology (AnE), and Theoretical and Computational Ecology (IBED, FNWI)
Subjects: 0106 biological sciences, Branta leucopsis, Range (biology), Ontogeny, growth, Foraging, Zoology, Biology, migration, 010603 evolutionary biology, 01 natural sciences, moult, arctic, Juvenile, Ecology, Evolution, Behavior and Systematics, metabolic rate, 010604 marine biology & hydrobiology, life-history, latitude, Interspecific competition, biology.organism_classification, body mass, plasticity, international, Basal metabolic rate, [SDE]Environmental Sciences, Moulting
Abstract: While many species suffer from human activities, some like geese benefit and may show range expansions. In some cases geese (partially) gave up migration and started breeding at wintering and stopover grounds. Range expansion may be facilitated and accompanied by physiological changes, especially when associated with changes in migratory behaviour. Interspecific comparisons found that migratory tendency is associated with a higher basal or resting metabolic rate (RMR). We compared RMR of individuals belonging to a migratory and a sedentary colony of barnacle geese Branta leucopsis. The migratory colony is situated in the traditional arctic breeding grounds (Russia), whereas the sedentary colony has recently been established in the now shared wintering area (the Netherlands). We measured RMR by oxygen consumption (urn:x-wiley:00301299:media:oik12892:oik12892-math-0001) during two ontogenetic phases (juvenile growth and adult wing moult). We also investigated juvenile growth rates and adult body mass dynamics. Mass‐independent urn:x-wiley:00301299:media:oik12892:oik12892-math-0002 was 13.6% lower in goslings from the sedentary colony than in goslings from the migratory colony. Similarly, in adult geese, mass‐independent urn:x-wiley:00301299:media:oik12892:oik12892-math-0003 was 15.5% lower in sedentary than in migratory conspecifics. Goslings in the Netherlands grew 36.2% slower than goslings in Russia, while we found no differences in body dimensions in adults. Adult geese from both colonies commenced wing moult with similar body stores, but whereas Russian barnacle geese maintained this level throughout moult, body stores in geese from the Netherlands fell, being 8.5% lower half‐way through the moult. We propose that the colony differences in resting metabolic rate, growth rate and body mass dynamics during moult can be explained by environmental and behavioural differences. The less stringent time constraints combined with poorer foraging opportunities allow for a smaller ‘metabolic machinery’ in non‐migratory geese. Our analysis suggests that range expansion may be associated with changes in physiology, especially when paired with changes in migratory tendency.
Published: 2019
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25. Backward lasing of singly ionized nitrogen ions pumped by femtosecond laser pulses

Author: Zhengquan Fan, André Mysyrowicz, Pengji Ding, Yi Liu, Qingqing Liang, Aurélien Houard, Vladimir Tikhonchuk, Chenhao Kou, Rostyslav Danylo, Xiang Zhang, Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Interaction Laser-Matière (ILM), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Division of Combustion Physics, Lund Institute of Technology, Lund University [Lund]-Lund University [Lund], Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), ELI Beamlines, and European Project
Subjects: [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Materials science, Nonlinear optics, Physics and Astronomy (miscellaneous), General Engineering, General Physics and Astronomy, Plasma, Ultrashort laser, Laser, 01 natural sciences, Ion, law.invention, 010309 optics, Filamentation, law, Ionization, 0103 physical sciences, Femtosecond, Lasing effect, Atomic physics, 010306 general physics, Radiant intensity, Lasing threshold, Excitation, Filamentation laser
Abstract: International audience; We report on the observation of backward lasing at 391.4 nm of nitrogen ions pumped by linearly polarized intense femtosecond pulses at 800 nm. The strongly enhanced spectral intensity at 391.4 nm, as well as the amplification of an externally injected backward seeding pulse, confirm that the backward 391.4 nm signal is due to optical amplification in the nitrogen gas plasma. Compared to the forward emission at 391.4 nm, the optimal backward emission is achieved at a lower gas pressure around 10 mbar, which is due to asymmetry of the backward and forward directions rooted in the traveling excitation geometry. Comparison of the signals in pure nitrogen and air revealed a strong quenching effect of the oxygen molecules, preventing backward lasing action in ambient air.
Published: 2020
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26. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries

Author: NCD Risk Factor Collaboration (NCD-RisC), [missing], Taddei, Cristina, Jackson, Rod, Zhou, Bin, Bixby, Honor, Danaei, Goodarz, Di Cesare, Mariachiara, Kuulasmaa, Kari, Hajifathalian, Kaveh, Bentham, James, Bennett, James E, Aekplakorn, Wichai, Cifkova, Renata, Dallongeville, Jean, DeBacquer, Dirk, Giampaoli, Simona, Gudnason, Vilmundur, Khang, Young-Ho, Laatikainen, Tiina, Mann, JimI, Marques-Vidal, Pedro, Mensah, George A, Müller-Nurasyid, Martina, Ninomiya, Toshiharu, Petkeviciene, Janina, Rodríguez-Artalejo, Fernando, Servais, Jennifer, Söderberg, Stefan, Stavreski, Bill, Wilsgaard, Tom, Zdrojewski, Tomasz, Zhao, Dong, Stevens, Gretchen A, Savin, Stefan, Cowan, Melanie J, Riley, Leanne M, Ezzati, Majid, Adams, Robert J, Ahrens, Wolfgang, Amouyel, Philippe, Amuzu, Antoinette, Anderssen, Sigmund A, Ariansen, Inger, Arveiler, Dominique, Aspelund, Thor, Auvinen, Juha, Avdicová, Mária, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Bata, Iqbal, Baur, Louise A, Beaglehole, Robert, Bernotiene, Gailute, Bi, Yufang, Bienek, Asako, Björkelund, Cecilia, Bo, Simona, Boehm, Bernhard O, Bonaccio, Marialaura, Bongard, Vanina, Borchini, Rossana, Borghs, Herman, Breckenkamp, Juergen, Brenner, Hermann, Bruno, Graziella, Busch, Markus A, Cabrera de León, Antonio, Capuano, Vincenzo, Casanueva, Felipe F, Casas, Juan-Pablo, Caserta, Carmelo A, Censi, Laura, Chen, Fangfang, Chen, Shuohua, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Chudek, Jerzy, Claessens, Frank, Clarke, Janine, Clays, Els, Cooper, Cyrus, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Crujeiras, Ana B, Cui, Liufu, D'Arrigo, Graziella, Dauchet, Luc, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, De Smedt, Delphine, Dennison, Elaine, Deschamps, Valérie, DiCastelnuovo, Augusto, Dobson, Annette J, Donfrancesco, Chiara, Döring, Angela, Drygas, Wojciech, Du, Yong, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, Elosua, Roberto, Eriksson, Johan G, Evans, Alun, Faeh, David, Felix-Redondo, Francisco J, Fernández-Bergés, Daniel, Ferrari, Marika, Ferrieres, Jean, Finn, Joseph D, Forslund, Ann-Sofie, Forsner, Maria, Frontera, Guillermo, Fujita, Yuki, Gaciong, Zbigniew, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Goltzman, David, GonzalezGross, Marcela, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Gregor, Ronald D, Grodzicki, Tomasz, Grosso, Giuseppe, Gruden, Grabriella, Gu, Dongfeng, Guallar-Castillón, Pilar, Gudmundsson, Elias F, Guessous, Idris, Gunnlaugsdottir, Johanna, Gutzwiller, Felix, Hardy, Rebecca, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuna, Herrala, Sauli, TapaniHihtaniemi, Ilpo, Hobbs, Michael, Hopman, Wilma M, MaríaHuerta, José, Huybrechts, Inge, Iacoviello, Licia, Iannone, Anna G, Ikeda, Nayu, Iwasaki, Masanori, Jamrozik, Konrad, Janszky, Imre, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jennings, Garry, Jeong, Seung-lyeal, QiangJiang, Chao, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Jóźwiak, Jacek, Kajantie, Eero O, Kauhanen, Jussi, Keil, Ulrich, Keinänen-Kiukaanniemi, Sirkka, Kersting, Mathilde, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Kim, Jeongseon, Kim, Yeon-Yong, Klumbiene, Jurate, Knoflach, Michael, Ko, Stephanie, Kolle, Elin, Korpelainen, Raija, Koskinen, Seppo, Kouda, Katsuyasu, Kratzer, Wolfgang, Kriemler, Susi, Krokstad, Steinar, Kujala, Urho M, Kurjata, Pawel, HingLam, Tai, Lanska, Vera, Lappas, Georg, Laugsand, Lars E, Lee, Jeonghee, Lehtimäki, Terho, Li, Yanping, Lilly, Christa L, Lin, Xu, Lind, Lars, Lissner, Lauren, Liu, Jing, Lopez-Garcia, Esther, Lorbeer, Roberto, EugenioLozano, José, Luksiene, Dalia, Lundqvist, Annamari, Lundqvist, Robert, Lytsy, Per, Ma, Guansheng, Machi, Suka, Maggi, Stefania, Magliano, Dianna J, Manzato, Enzo, Mathiesen, Ellisiv B, McLachlan, Stela, McLean, Rachael M, McLean, Scott B, Meirhaeghe, Aline, Meisinger, Christa, Metcalf, Patricia, Mi, Jie, Miller, Jody C, Moreno, Luis A, Morin, Suzanne, Mossakowska, Malgorzata, Muiesan, Maria L, Mursu, Jaakko, Nakamura, Harunobu, Námešná, Jana, Nauck, Matthias, MariaNavarrete-Muñoz, Eva, Neal, William A, Nenko, Ilona, Niiranen, Teemu J, Ning, Guang, Noale, Marianna, Norie, Sawada, Noto, Davide, O'Neill, Terence, O'Reilly, Dermot, Oh, Kyungwon, Olafsson, Örn, MichelPaccaud, Fred, Pajak, Andrzej, Palmieri, Luigi, Panza, Francesco, Parnell, Winsome R, Peltonen, Markku, Peters, Annette, Petersmann, Astrid, Pigeot, Iris, Pilotto, Lorenza, Piwonska, Aleksandra, Plans-Rubió, Pedro, Porta, Miquel, Price, Jacqueline F, Puder, Jardena J, Puhakka, Soile E, Radisauskas, Ricardas, Raitakari, Olli, Ramos, Rafel, Redon, Josep, Rigo, Fernando, Rodriguez-Perez, MaríadelCristo, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Roy, Joel G R, Ruidavets, Jean-Bernard, Rutkowski, Marcin, Salanave, Benoit, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sans, Susana, Saramies, Jouko L, Saum, Kai-Uwe, Scheidt-Nave, Christa, Schienkiewitz, Anja, Schipf, Sabine, Schmidt, Carsten O, Schöttker, Ben, Sebert, Sylvain, Sen, Abhijit, Shaw, Jonathan E, Shibuya, Kenji, WookShin, Dong, Shiri, Rahman, Simons, Judith, Simons, Leon A, Sjöström, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Solfrizzi, Vincenzo, Sonestedt, Emily, Soumare, Aicha, Staessen, Jan A, Stathopoulou, Maria G, Steene-Johannessen, Jostein, Stehle, Peter, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Sundström, Johan, Suriyawongpaisal, Paibul, Tamosiunas, Abdonas, JooTan, Eng, Taylor, Anne, Tell, Grethe, Thijs, Lutgarde, Tolonen, HannaK, Topór-Madry, Roman, JoséTormo, María, Torrent, Maties, Tsugane, Shoichiro, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Tzourio, Christophe, Uusitalo, Hannu M T, Van Herck, Koen, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lars, Vega, Tomas, Veronesi, Giovanni, Vioque, Jesus, Virtanen, JyrkiK, Visvikis-Siest, Sophie, Vollenweider, Peter, Voutilainen, Sari, Vrijheid, Martine, Wagner, Aline, Wagner, Anne, Wang, Ming-Dong, Wang, Qian, XingWang, Ya, Wannamethee, S Goya, Wei, Wenbin, Whincup, Peter H, Wiecek, Andrzej, Willeit, Johann, Willeit, Peter, Wojtyniak, Bogdan, Wong, Andrew, Woodward, Mark, GiwercmanWu, Aleksander, Wu, Frederick C, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yoshihara, Akihiro, Zambon, Sabina, Zhao, Wenhua, Imperial College London, University of Auckland [Auckland], Harvard T.H. Chan School of Public Health, Middlesex University, National Institute for Health and Welfare [Helsinki], Weill Medical College of Cornell University [New York], University of Kent [Canterbury], Mahidol University [Bangkok], Charles University [Prague] (CU), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Universiteit Gent = Ghent University [Belgium] (UGENT), Istituto Superiore di Sanita [Rome], Icelandic Heart Association [Kopavogur, Iceland] (IHA), Seoul National University [Seoul] (SNU), University of Otago [Dunedin, Nouvelle-Zélande], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Helmholtz-Zentrum München (HZM), Kyushu University [Fukuoka], Universidad Autonoma de Madrid (UAM), CIBER de Epidemiología y Salud Pública (CIBERESP), Umeå University, The Arctic University of Norway (UiT), Medical University of Gdańsk, Capital University of Medical Sciences [Beijing] (CUMS), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Adelaide, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), London School of Hygiene and Tropical Medicine (LSHTM), Norwegian School of Sport Sciences = Norges idrettshøgskole [Oslo] (NIH), Norwegian Institute of Public Health [Oslo] (NIPH), Université de Strasbourg (UNISTRA), University of Iceland [Reykjavik], University of Oulu, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Medical University of Łódź (MUL), Università degli studi di Palermo - University of Palermo, Dalhousie University [Halifax], The University of Sydney, Public Health Agency of Canada, University of Gothenburg (GU), University of Turin, Nanyang Technological University [Singapour], Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Faculté de Médecine [Rangueil], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse], Universität Bielefeld = Bielefeld University, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Robert Koch Institute [Berlin] (RKI), Universidad de La Laguna [Tenerife - SP] (ULL), Universidade de Santiago de Compostela [Spain] (USC ), University College of London [London] (UCL), University of Silesia in Katowice, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Southampton, Biomolécules et inflammation pulmonaire, Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Santé publique France - French National Public Health Agency [Saint-Maurice, France], University of Queensland [Brisbane], IMIM-Hospital del Mar, Generalitat de Catalunya, Queen's University [Belfast] (QUB), Universität Zürich [Zürich] = University of Zurich (UZH), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Manchester [Manchester], Kindai University, Medical University of Warsaw - Poland, Università degli studi di Catania [Catania], Geneva University Hospital (HUG), Universitá degli Studi dell’Insubria, McGill University = Université McGill [Montréal, Canada], Universidad Politécnica de Madrid (UPM), Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institute for Clinical and Experimental Medicine (IKEM), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Bergen (UiB), Tulane University, Chinese Center for Disease Control and Prevention, Oulu University Hospital [Oulu], The University of Western Australia (UWA), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Niigata University, Norwegian University of Science and Technology (NTNU), Simon Fraser University (SFU.ca), University of Eastern Finland, Westfälische Wilhelms-Universität Münster (WWU), Innsbruck Medical University [Austria] (IMU), Universitätsklinikum Ulm - University Hospital of Ulm, University of Jyväskylä (JYU), The University of Hong Kong (HKU), Sahlgrenska Academy at University of Gothenburg [Göteborg], Tampere University Hospital, University of Tampere [Finland], West Virginia University [Morgantown], University of Chinese Academy of Sciences [Beijing] (UCAS), Uppsala Universitet [Uppsala], Universität Greifswald - University of Greifswald, Peking University [Shenzhen], The Jikei University School of Medicine, Baker Heart and Diabetes Institute (AUSTRALIA), Universita degli Studi di Padova, University of Edinburgh, University of Zaragoza - Universidad de Zaragoza [Zaragoza], International Institute of Molecular and Cell Biology [Warsaw] (IIMCB), Università degli Studi di Brescia [Brescia], Konan University [Kobe, Japan], University of Turku, Shanghai Jiao Tong University School of Medicine, Department of Epidemiology and Biostatistics, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, Department of Epidemiology, Health Economics and Public Health, UMR 558 INSERM, Université de Toulouse, Centre Hospitalier Universitaire de Toulouse, Unité de Surveillance et d'Epidémiologie Nutritionnelle (USEN), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut de Veille Sanitaire (INVS)-Université Paris 13 (UP13), Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain, parent, Department of Chronic Disease Prevention, Institute for plasma research, Institute for Plasma Research, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], Department of Reproductive Endocrinology, University of Bari Aldo Moro (UNIBA), Nutritional Epidemiology, Department of Clinical Sciences, Clinical Research Center, Lund University [Lund]-Lund University [Lund], Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Applied Food Science, Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Research Unit Hypertension and Cardiovascular Epidemiology [Louvain, Belgique], Studies Coordinating Centre [Louvain, Belgique], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), National Cancer Center, University of Kuopio, Epidémiologie cardiovasculaire et métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Tampere University, Department of Andrology and Endocrinology, Katholieke Universiteit Leuven, Norwegian University of Science and Technology [Trondheim] (NTNU), Departamento de Salud Pública, Universidad Miguel Hernández [Elche] (UMH), Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Department of Internal Medicine, School of Public Health and Clinical Nutrition, Epidemiologia Ambiental, Centre for Research in Environmental Epidemiology (CREAL)-Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) of Pamplona-Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Department of Epidemiology and Public Health, EA 3430, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Medical University of Silesia (SUM), University of Innsbruck, National Institute of Hygiene Warsaw, The Georges Institute for International Health, Naval Research Laboratory (NRL), Grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z, Ministry of Health of the Czech Republic (grant number 15-27109A), UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología, HUS Children and Adolescents, Department of Public Health, Universidad Autónoma de Madrid (UAM), Università degli studi di Torino = University of Turin (UNITO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), CHU Toulouse [Toulouse], Université Paris 13 (UP13)-Institut de Veille Sanitaire (INVS)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM), Taddei, C, Zhou, B, Bixby, H, Danaei, G, Di Cesare, M, Kuulasmaa, K, Hajifathalian, K, Bentham, J, Bennett, JE, Aekplakorn, W, Cifkova, R, Dallongeville, J, DeBacquer, D, Giampaoli, S, Gudnason, V, Khang, Y-O, Laatikainen, T, Mann, JI, Marques-Vidal, P, Mensah, GA, Müller-Nurasyid, M, Ninomiya, T, Petkeviciene, J, Rodríguez-Artalejo, F, Servais, J, Söderberg, S, Stavreski, B, Wilsgaard, T, Zdrojewski, T, Zhao, D, Stevens, GA, Savin, S, Cowan, Mj, Riley, LM, Ezzati, M, Adams, R, Ahrens, W, Amouyel, P, Amuzu, A, Anderssen, SA, Ariansen, I, Arveiler, D, Aspelund, T, Auvinen, A, Avdicová, M, Banach, M, Bandosz, P, Banegas. JR, Barbagallo, CM, Bata, I, Baur, LA, Beaglehole, R, Bennet, JE, Bernotiene, G, Bi, Y, Bienek, A, Björkelund, C, Bo, S, Boehm, BO, Bonaccio, M, Bongard, V, Borchini, R, Borghs, H, Breckenkamp, J, Brenner, H, Bruno, G, Busch, MA, CabreradeLeón, A, Capuano, V, Casanueva, FF, Casas, J-P, Caserta, CA, Censi, L, Chen, F, Chen, S, Chirlaque, M-D, Cho, B, Cho, Y, Chudek, J, Claessens, F, Clarke, J, Clays, E, Cooper, C, Costanzo, S, Cottel, D, Cowell C, Crujeiras, AB, Cui, L, D'Arrigo, G, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Dennison, E, Desschamps, V, Di Castelnuovo, A, Dobson, AJ, Donfrancesco, C, Döring, A, Doua, K, Drygas, W, Du, Y, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, Elousa, R, Eriksson, JG, Evans, A, Faeh, D, Felix-Redondo, FJ, Fernández-Bergés, D, Ferrari, M, Ferrieres, J, Finn, JD, Forslund, A-S, Forsner, M, Frontera, G, Fujita, Y, Gaciong, Z, Galvano, F, Gao, J, Garcia-de-la-Hera, M, Garnett, SP, Gaspoz, J-M, Gasul, L, Gates, L, Gianfagna, F, Gill, TK, Giovannelli, J, Goltzman, D, GonzalezGross, M, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Gregor, RD, Grodzicki, T, Grosso, G, Gruden, G, Gu, D, Guallar-Castillón, P, Gudmundsson, EF, Guessous, I, Gunnlaugsdottir J, Gutzwiller, F, Hardy, R, Hata, J, Haugsgjerd, T, Hayes, AJ, He, H, He, Y, Herrala, S, Hihtaniemi, IP, Hobbs, M, Hopman, WM, Huerta, JM, Huybrechts, I, Iacoviello, L, Iannone, AG, Ikeda, N, Iwasaki, M, Jackson, R, Jamrozi, K, Janszky, I, Jarvelin, M-R, Jasienska, G, Jennings, G, Jeong, S-L, Jiang, CQ, Joffres, M, Jokelainen, JJ, Jonas, JB, Jóźwiak, J, Kajantie, EO, Kauhanen, K, Keil, U, Keinänen-Kiukaanniemi, S, Kersting, M, Khang, Y-H, Kiechl-Kohlendorfer, U, Kiechl, S, Kim, J, Kim, Y-Y, Klumbiene, J, Knoflach, M, Ko, S, Kolle, E, Korpelainen, R, Koskinen, S, Kouda, K, Kratzer, W, Kriemler, S, Krokstad, S, Kujala,UM, Kurjata, P, Lam, TH, Lanska, V, Lappas , G, Laugsand, LE, Lee, J, Lehtimäki, T, Li, Y, Lilly, C, Lin, X, Lind, L, Lissner, L, Liu, J, Lopez-Garcia, E, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lundqvist, R, Lytsy, P, Ma, G, Machi, S, Maggi, S, Magliano, DJ, Manzato, E, Mathiesen, EB, McLachlan, S, McLean, RM, Meirhaeghe, A, Metcalf, P, Mi, JM, Miller, JC, Moreno, LA, Morin, S, Mossakowska, M, Muiesan, ML, Mursu, J, Nakamura, H, Námešná, J, Navarrete-Muñoz, EM, Neal, WA, Nenko, I, Niiranen, T, Ning, G, Noale, M, Norie, S, Noto, Davide, O’Neill, T, O'Reilly, D, Oh, K, Olafsson, O, Paccaud, F, Pajak, A, Palmieri, L, Panza, F, Parnell, WR, Peltonen, M, Peters, A, Petersmann, A, P Pigeot, I, Pilotto, L, Piwonska, A, Pedro Plans-Rubió, P, Porta, M, Price, JF, Puder, JJ, Puhakka, SE, Radisauskas, R, Raitakari, O, Ramos, R, Redon, J, Rigo, F, Rodriguez-Perez, MdC, Romaguera, D, Ronkainen, K, Rosengren, A, Roy, JGR, Ruidavets, JB, Rutkowski, M, Salanave, B, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Sans, S, Saramies, JL, Saum, K-U, Scheidt-Nave, C, Schienkiewitz, A, Schipf, S, Schmidt, CO, Schottker, B, Sebert S, Sen, A, Shaw, JE, Shibuya, K, Shin, DO, Shiri, R, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stieber, J, Stöckl, D, Stokwiszewski, J, Sundström, J, Suriyawongpaisal, P, Tamosiunas, A, Tan, E, Taylor, A, Tell, G, Thijs, L, Tolonen, HK, Topór-Madry, R, Tormo, MJ, Torrent, M, Tsugane, S, Tuomainen, T-P, Tuomilehto, J, Tzourio, C, Uusitalo, HMT, Van Herck, K, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Veronesi, G, Vioque, P, Virtanen, JK, Visvikis-Siest, S, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wagner, A, Wang, M-D, Wang, Q, Wang YX, Wannamethee, SG, Wei, W, Whincup, PH, Wiecek, A, Willeit, J, Willeit, P, Wojtyniak, B, Wong, A, Woodward, M, Wu, FC, JianFeng Wu, JF, Wu, SL, Xu, H, Xu, L, Yan, W, Yang, X, Ye, X, Yoshihara, A, Zambon, S, Zhao, W, NCD Risk Factor Collaboration (NCD-RisC), Jackson, R., Zhou, B., Bixby, H., Danaei, G., Di Cesare, M., Kuulasmaa, K., Hajifathalian, K., Bentham, J., Bennett, J.E., Aekplakorn, W., Cifkova, R., Dallongeville, J., DeBacquer, D., Giampaoli, S., Gudnason, V., Khang, Y.H., Laatikainen, T., Mann, J., Marques-Vidal, P., Mensah, G.A., Müller-Nurasyid, M., Ninomiya, T., Petkeviciene, J., Rodríguez-Artalejo, F., Servais, J., Söderberg, S., Stavreski, B., Wilsgaard, T., Zdrojewski, T., Zhao, D., Stevens, G.A., Savin, S., Cowan, M.J., Riley, L.M., Ezzati, M., Adams, R.J., Ahrens, W., Amouyel, P., Amuzu, A., Anderssen, S.A., Ariansen, I., Arveiler, D., Aspelund, T., Auvinen, J., Avdicová, M., Banach, M., Bandosz, P., Banegas, J.R., Barbagallo, C.M., Bata, I., Baur, L.A., Beaglehole, R., Bernotiene, G., Bi, Y., Bienek, A., Björkelund, C., Bo, S., Boehm, B.O., Bonaccio, M., Bongard, V., Borchini, R., Borghs, H., Breckenkamp, J., Brenner, H., Bruno, G., Busch, M.A., Cabrera de León, A., Capuano, V., Casanueva, F.F., Casas, J.P., Caserta, C.A., Censi, L., Chen, F., Chen, S., Chirlaque, M.D., Cho, B., Cho, Y., Chudek, J., Claessens, F., Clarke, J., Clays, E., Cooper, C., Costanzo, S., Cottel, D., Cowell, C., Crujeiras, A.B., Cui, L., D'Arrigo, G., Dauchet, L., De Backer, G., De Bacquer, D., de Gaetano, G., De Henauw, S., De Smedt, D., Dennison, E., Deschamps, V., DiCastelnuovo, A., Dobson, A.J., Donfrancesco, C., Döring, A., Drygas, W., Du, Y., Dziankowska-Zaborszczyk, E., Eggertsen, R., Ekelund, U., Elosua, R., Eriksson, J.G., Evans, A., Faeh, D., Felix-Redondo, F.J., Fernández-Bergés, D., Ferrari, M., Ferrieres, J., Finn, J.D., Forslund, A.S., Forsner, M., Frontera, G., Fujita, Y., Gaciong, Z., Galvano, F., Gao, J., Garcia-de-la-Hera, M., Garnett, S.P., Gaspoz, J.M., Gasull, M., Gates, L., Gianfagna, F., Gill, T.K., Giovannelli, J., Goltzman, D., GonzalezGross, M., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Gregor, R.D., Grodzicki, T., Grosso, G., Gruden, G., Gu, D., Guallar-Castillón, P., Gudmundsson, E.F., Guessous, I., Gunnlaugsdottir, J., Gutzwiller, F., Hardy, R., Hata, J., Haugsgjerd, T., Hayes, A.J., He, J., He, Y., Herrala, S., TapaniHihtaniemi, I., Hobbs, M., Hopman, W.M., MaríaHuerta, J., Huybrechts, I., Iacoviello, L., Iannone, A.G., Ikeda, N., Iwasaki, M., Jamrozik, K., Janszky, I., Jarvelin, M.R., Jasienska, G., Jennings, G., Jeong, S.L., QiangJiang, C., Joffres, M., Jokelainen, J.J., Jonas, J.B., Jóźwiak, J., Kajantie, E.O., Kauhanen, J., Keil, U., Keinänen-Kiukaanniemi, S., Kersting, M., Kiechl-Kohlendorfer, U., Kiechl, S., Kim, J., Kim, Y.Y., Klumbiene, J., Knoflach, M., Ko, S., Kolle, E., Korpelainen, R., Koskinen, S., Kouda, K., Kratzer, W., Kriemler, S., Krokstad, S., Kujala, U.M., Kurjata, P., HingLam, T., Lanska, V., Lappas, G., Laugsand, L.E., Lee, J., Lehtimäki, T., Li, Y., Lilly, C.L., Lin, X., Lind, L., Lissner, L., Liu, J., Lopez-Garcia, E., Lorbeer, R., EugenioLozano, J., Luksiene, D., Lundqvist, A., Lundqvist, R., Lytsy, P., Ma, G., Machi, S., Maggi, S., Magliano, D.J., Manzato, E., Mathiesen, E.B., McLachlan, S., McLean, R.M., McLean, S.B., Meirhaeghe, A., Meisinger, C., Metcalf, P., Mi, J., Miller, J.C., Moreno, L.A., Morin, S., Mossakowska, M., Muiesan, M.L., Mursu, J., Nakamura, H., Námešná, J., Nauck, M., MariaNavarrete-Muñoz, E., Neal, W.A., Nenko, I., Niiranen, T.J., Ning, G., Noale, M., Norie, S., Noto, D., O'Neill, T., O'Reilly, D., Oh, K., Olafsson, Ö., MichelPaccaud, F., Pajak, A., Palmieri, L., Panza, F., Parnell, W.R., Peltonen, M., Peters, A., Petersmann, A., Pigeot, I., Pilotto, L., Piwonska, A., Plans-Rubió, P., Porta, M., Price, J.F., Puder, J.J., Puhakka, S.E., Radisauskas, R., Raitakari, O., Ramos, R., Redon, J., Rigo, F., Rodriguez-Perez, M., Romaguera, D., Ronkainen, K., Rosengren, A., Ruidavets, J.B., Rutkowski, M., Salanave, B., Salmerón, D., Salomaa, V., Salonen, J.T., Salvetti, M., Sans, S., Saramies, J.L., Saum, K.U., Scheidt-Nave, C., Schienkiewitz, A., Schipf, S., Schmidt, C.O., Schöttker, B., Sebert, S., Sen, A., Shaw, J.E., Shibuya, K., WookShin, D., Shiri, R., Simons, J., Simons, L.A., Sjöström, M., Slowikowska-Hilczer, J., Slusarczyk, P., Solfrizzi, V., Sonestedt, E., Soumare, A., Staessen, J.A., Stathopoulou, M.G., Steene-Johannessen, J., Stehle, P., Stieber, J., Stöckl, D., Stokwiszewski, J., Sundström, J., Suriyawongpaisal, P., Tamosiunas, A., JooTan, E., Taylor, A., Tell, G., Thijs, L., Tolonen, H., Topór-Madry, R., JoséTormo, M., Torrent, M., Tsugane, S., Tuomainen, T.P., Tuomilehto, J., Tzourio, C., Van Herck, K., Vanderschueren, D., Vanuzzo, D., Vatten, L., Vega, T., Veronesi, G., Vioque, J., Virtanen, J., Visvikis-Siest, S., Vollenweider, P., Voutilainen, S., Vrijheid, M., Wagner, A., Wang, M.D., Wang, Q., XingWang, Y., Wannamethee, S.G., Wei, W., Whincup, P.H., Wiecek, A., Willeit, J., Willeit, P., Wojtyniak, B., Wong, A., Woodward, M., GiwercmanWu, A., Wu, F.C., Wu, S., Xu, H., Xu, L., Yan, W., Yang, X., Ye, X., Yoshihara, A., Zambon, S., Zhao, W., Universiteit Gent = Ghent University (UGENT), Istituto Superiore di Sanità (ISS), Helmholtz Zentrum München = German Research Center for Environmental Health, Kyushu University, The Arctic University of Norway [Tromsø, Norway] (UiT), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Catania = University of Catania (Unict), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Università degli Studi di Padova = University of Padua (Unipd), Università degli Studi di Brescia = University of Brescia (UniBs), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Laboratoire Chrono-environnement (UMR 6249) (LCE), Leopold Franzens Universität Innsbruck - University of Innsbruck, National Institute of Public Health - National Institute of Hygiene [Poland], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Medical University of Silesia, Katowice, University of Helsinki, National Institute for Health and Welfare, University of Helsinki, University of Helsinki, and University of Helsinki, Finnish Institute of Occupational Health
Subjects: Male, gupo de ascendencia continental asiática, Settore MED/09 - Medicina Interna, Total Cholesterol, Ldl Cholesterol, Hdl Cholesterol, Blood Lipids, Multi-country Study, Epidemiology, kolesteroli, humanos, Blood lipids, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, triglicéridos, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, HDL cholesterol, Medicine and Health Sciences, CARDIOVASCULAR RISK-FACTORS, Medicine, 030212 general & internal medicine, mediana edad, lípidos, Public, Environmental & Occupational Health, 2. Zero hunger, anciano, education.field_of_study, Age Factors, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Middle Aged, colesterol, adulto, kansainvälinen vertailu, Lipids, 3142 Public health care science, environmental and occupational health, 3. Good health, Europe, Cholesterol, Population Surveillance, LDL cholesterol, SERUM-LIPIDS, Female, lipids (amino acids, peptides, and proteins), Life Sciences & Biomedicine, Adult, Asian Continental Ancestry Group, Canada, Total cholesterol, blood lipids, multi-country study, medicine.medical_specialty, Asia, Medicina, European Continental Ancestry Group, Population, Nursing, HDL-kolesteroli, White People, DIETARY-FAT, 03 medical and health sciences, Sex Factors, Asian People, kansanterveys, vigilancia de la población, Humans, CORONARY-HEART-DISEASE, ddc:610, LDL-kolesteroli, education, Triglycerides, METAANALYSIS, Aged, INDIVIDUAL DATA, Science & Technology, business.industry, Omvårdnad, blood lipid, Cholesterol, HDL, Ecological study, nutritional and metabolic diseases, Cholesterol, LDL, United States, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Cholesterol/blood, Lipids/blood, Population Surveillance/methods, Triglycerides/blood, chemistry, WORLDWIDE TRENDS, Multi-country study, grupo de ascendencia continental europea, business, HIGH-DENSITY-LIPOPROTEIN, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography, Lipoprotein
Abstract: Artículo con numerosos autores. Sólo quedan reflejados el primero, los pertenecientes a la UAM y el colectivo, Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol., This work was supported by the Wellcome Trust (grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z). R.C. acknowledges funding from the Ministry of Health of the Czech Republic (grant number 15-27109A)
Published: 2020
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27. A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Author: Christian Hammer, Lluis Quintana-Murci, Allyson L. Byrd, Jacques Fellay, Cécile Alanio, Petar Scepanovic, Valentin Partula, Mathilde Touvier, Olivier Lantz, Stanislas Mondot, Jacob Bergstedt, Etienne Patin, Darragh Duffy, Matthew L. Albert, Flavia Hodel, Ecole Polytechnique Fédérale de Lausanne (EPFL), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Genentech, Inc. [San Francisco], Perelman School of Medicine, University of Pennsylvania [Philadelphia], Lund University [Lund], Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunobiologie des Cellules dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Swiss Institute of Bioinformatics [Genève] (SIB), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), This work benefited from the support of the French government’s Invest in the Future Program, managed by the Agence Nationale de la Recherche (ANR, reference 10-LABX-69-01). It was also supported by a grant from the Swiss National Science Foundation (31003A_175603 to JF)., We would like to thank to all the donors for their contribution to the study. The Milieu Intérieur Consortium is composed of the following team leaders: Laurent Abel (Hôpital Necker, Paris, France), Andres Alcover (Institut Pasteur, Paris, France), Hugues Aschard (Institut Pasteur, Paris, France), Kalla Astrom (Lund University, Lund, Sweden), Philippe Bousso (Institut Pasteur, Paris, France), Pierre Bruhns (Institut Pasteur, Paris, France), Ana Cumano (Institut Pasteur, Paris, France), Caroline Demangel (Institut Pasteur, Paris, France), Ludovic Deriano (Institut Pasteur, Paris, France), James Di Santo (Institut Pasteur, Paris, France), Françoise Dromer (Institut Pasteur, Paris, France), Darragh Duffy (Institut Pasteur, Paris, France), Gérard Eberl (Institut Pasteur, Paris, France), Jost Enninga (Institut Pasteur, Paris, France), Jacques Fellay (EPFL, Lausanne, Switzerland), Odile Gelpi (Institut Pasteur, Paris, France), Ivo Gomperts-Boneca (Institut Pasteur, Paris, France), Milena Hasan (Institut Pasteur, Paris, France), Serge Hercberg (Université Paris 13, Paris, France), Olivier Lantz (Institut Curie, Paris, France), Claude Leclerc (Institut Pasteur, Paris, France), Hugo Mouquet (Institut Pasteur, Paris, France), Sandra Pellegrini (Institut Pasteur, Paris, France), Stanislas Pol (Hôpital Côchin, Paris, France), Antonio Rausell (INSERM UMR 1163 – Institut Imagine, Paris, France), Lars Rogge (Institut Pasteur, Paris, France), Anavaj Sakuntabhai (Institut Pasteur, Paris, France), Olivier Schwartz (Institut Pasteur, Paris, France), Benno Schwikowski (Institut Pasteur, Paris, France), Spencer Shorte (Institut Pasteur, Paris, France), Vassili Soumelis (Institut Curie, Paris, France), Frédéric Tangy (Institut Pasteur, Paris, France), Eric Tartour (Hôpital Européen George Pompidou, Paris, France), Antoine Toubert (Hôpital Saint-Louis, Paris, France), Mathilde Touvier (Université Paris 13, Paris, France), Marie-Noëlle Ungeheuer (Institut Pasteur, Paris, France), Matthew L. Albert (Roche Genentech, South San Francisco, CA, USA), and Lluis Quintana-Murci (Institut Pasteur, Paris, France). Matthew L. Albert and Lluis Quintana-Murci are the co-coordinators of the consortium. Additional information can be found at http://www.milieuinterieur.fr/en., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Vougny, Marie-Christine, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pennsylvania, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France - Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Institut Curie-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR: 10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Fellay, Jacques [0000-0002-8240-939X], Apollo - University of Cambridge Repository, and Fellay, Jacques
Subjects: Male, population-structure, imputation, Genome-wide association study, dna, Cohort Studies, Feces, 0302 clinical medicine, GWAS, Gut, 16S rRNA gene sequencing, media_common, milieu-interieur, 0303 health sciences, dynamics, Genomics, Middle Aged, Healthy Volunteers, 3. Good health, 030220 oncology & carcinogenesis, Cohort, Medical genetics, lcsh:QR100-130, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Demographics, Sex ratio, Human, Adult, Microbiology (medical), medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, media_common.quotation_subject, Single-nucleotide polymorphism, Biology, Environment, Microbiology, lcsh:Microbial ecology, Young Adult, 03 medical and health sciences, Genetic variation, medicine, Humans, Microbiome, genome, Life Style, Aged, Demography, 030304 developmental biology, inference, Healthy, Bacteria, Host (biology), Research, Gastrointestinal Microbiome, extraction, 030217 neurology & neurosurgery, Imputation (genetics), Diversity (politics)
Abstract: Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Intérieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stratified across five decades of life (age 20–69), were recruited. We generated 16S ribosomal RNA profiles from stool samples for 858 participants. We investigated genetic and non-genetic factors that contribute to individual differences in fecal microbiome composition. Results Among 110 demographic, clinical, and environmental factors, 11 were identified as significantly correlated with α-diversity, ß-diversity, or abundance of specific microbial communities in multivariable models. Age and blood alanine aminotransferase levels showed the strongest associations with microbiome diversity. In total, all non-genetic factors explained 16.4% of the variance. We then searched for associations between > 5 million single nucleotide polymorphisms and the same indicators of fecal microbiome diversity, including the significant non-genetic factors as covariates. No genome-wide significant associations were identified after correction for multiple testing. A small fraction of previously reported associations between human genetic variants and specific taxa could be replicated in our cohort, while no replication was observed for any of the diversity metrics. Conclusion In a well-characterized cohort of healthy individuals, we identified several non-genetic variables associated with fecal microbiome diversity. In contrast, host genetics only had a negligible influence. Demographic and environmental factors are thus the main contributors to fecal microbiome composition in healthy individuals. Trial registration ClinicalTrials.gov identifier NCT01699893
Published: 2019
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28. Raman spectroscopy of mini-CAST soot with various fractions of organic compounds: Structural characterization during heating treatment from 25 °C to 1000 °C

Author: Sandra Tӧrӧk, Van Thai Pham, Per-Erik Bengtsson, Kim Cuong Le, Jonatan Henriksson, Thomas Pino, Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Combustion Physics, Lund Institute of Technology, and Lund University [Lund]-Lund University [Lund]
Subjects: Materials science, Photoluminescence, 020209 energy, General Chemical Engineering, Atom and Molecular Physics and Optics, Analytical chemistry, General Physics and Astronomy, Energy Engineering and Power Technology, 02 engineering and technology, Thermal treatment, medicine.disease_cause, complex mixtures, Physical Chemistry, symbols.namesake, 020401 chemical engineering, Soot, Vaporization, Organic compounds, 0202 electrical engineering, electronic engineering, information engineering, medicine, 0204 chemical engineering, Inert gas, ComputingMilieux_MISCELLANEOUS, Inert, General Chemistry, Condensed Matter Physics, Fuel Technology, 13. Climate action, Raman spectroscopy, symbols, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Volatility (chemistry)
Abstract: Soot particles undergo considerable changes in composition, morphology, as well as in internal structure during formation from the incipient particles to more mature aggregates, and still there is a lack of understanding of these mechanisms. In this study, soot produced by a mini-CAST soot generator was probed using Raman spectroscopy with focus on soot with large variation in size and fraction of organic compounds. The volatility of organic compounds and changes in internal bonding structures of the soot was surveyed by heating the samples from room temperature up to 1000 °C in a flow of inert N2 gas. The soot rich in organics showed more complex Raman spectra and stronger photoluminescence background. In particular, Raman signatures interpreted as the C H “out-of-plane” mode, ethers C O C, and carbonyl C O groups were observed. During the heating treatment, these signatures disappeared, which was related to vaporization of the organics. Moreover, an enhancement of Raman band intensity of mature soot during heating treatment was observed for the first time. Our study thus brings new information on structural and compositional changes for soot during heating treatment in an inert atmosphere.
Published: 2019
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29. Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls

Author: Caterina Terrile, Juliette Bouchereau, Valeria Tiranti, Marina Paviolo, Paule Bénit, Manuel Schiff, Malgorzata Rak, Allan G. Rasmusson, Holger Prokisch, Arcangela Iuso, Thomas Schwarzmayr, Pierre Rustin, Alessia Catania, Laura S. Kremer, Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unit of Medical Genetics and Neurogenetics [Milan, Italy], Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Institute of Human Genetics [Neuherberg] (IHG), Helmholtz-Zentrum München (HZM), Institute of Human Genetics [Munich, Germany], Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Centre de référence pour les erreurs innées du métabolisme [Hôpital Robert Debré - APHP], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Biology [Lund, Sweden] (Biology building A), Lund University [Lund, Sweden], Department of Pediatrics [Munich, Germany] (Dr. von Hauner Children’s Hospital), Ludwig-Maximilians-Universität München (LMU), This study was supported by the German BMBF and Horizon2020 through E-Rare project GENOMIT (01GM1603 and 01GM1906B to H.P.), Horizon2020 Project SOUND (633974 to H.P.), German Network for Mitochondrial Disorders (mitoNET 01GM1113C to H.P.), AMMi (Association contre les Maladies Mitochondriales) grants to M.P., P.R., P.B. and M.S., E-Rare project GENOMIT (ANR-15-RAR3–0012 to P.R., A.C. and M.S.), Italian Ministry of Health (RF-2016-02361495 to A.C.), Mitocon (Grant no. 2018–01 to V.T.), Mariani Foundation (V.T.)., ANR-15-RAR3-0012,GENOMIT,Mitochondrial Disorders- from a pan-European Registry to medical genetics, toward molecular mechanisms and new therapeutic options(2015), European Project: 633974,H2020,H2020-PHC-2014-two-stage,SOUND(2015), Helmholtz Zentrum München = German Research Center for Environmental Health, Lund University [Lund], Rak, Malgorzata, Mitochondrial Disorders- from a pan-European Registry to medical genetics, toward molecular mechanisms and new therapeutic options - - GENOMIT2015 - ANR-15-RAR3-0012 - E-Rare-3 - VALID, and Statistical multi-Omics UNDerstanding of Patient Samples - SOUND - - H20202015-09-01 - 2018-08-31 - 633974 - VALID
Subjects: 0301 basic medicine, Arabidopsis thaliana, [SDV]Life Sciences [q-bio], Arabidopsis, lcsh:Medicine, Mitochondrion, medicine.disease_cause, 0302 clinical medicine, NADH, NADPH Oxidoreductases, Pharmacology (medical), [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Cells, Cultured, Genetics (clinical), chemistry.chemical_classification, biology, Chemistry, NADH dehydrogenase, Mitochondria, Mitochondrial Diseases, Complex I, Alternative Dehydrogenases, Arabidopsis Thaliana, Atnda2, General Medicine, AtNDA2, ddc, [SDV] Life Sciences [q-bio], Mitochondrial respiratory chain, Biochemistry, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Mitochondrial diseases, Transfection, 03 medical and health sciences, Oxidoreductase, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Alternative dehydrogenases, Electron Transport Complex I, Arabidopsis Proteins, Superoxide Dismutase, Research, lcsh:R, NADPH Dehydrogenase, Fibroblasts, biology.organism_classification, Yeast, 030104 developmental biology, biology.protein, 030217 neurology & neurosurgery, Oxidative stress
Abstract: Background Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is permanently active in yeast naturally devoid of CI, plant alternative NADH dehydrogenases (NDH-2) support the oxidation of NADH only when the CI is metabolically inactive and conceivably when the concentration of matrix NADH exceeds a certain threshold. We therefore explored the feasibility of CI rescue by NDH-2 from Arabidopsis thaliana (At) in human CI defective fibroblasts. Results We showed that, other than ScNDI1, two different NDH-2 (AtNDA2 and AtNDB4) targeted to the mitochondria were able to rescue CI deficiency and decrease oxidative stress as indicated by a normalization of SOD activity in human CI-defective fibroblasts. We further demonstrated that when expressed in human control fibroblasts, AtNDA2 shows an affinity for NADH oxidation similar to that of CI, thus competing with CI for the oxidation of NADH as opposed to our initial hypothesis. This competition reduced the amount of ATP produced per oxygen atom reduced to water by half in control cells. Conclusions In conclusion, despite their promising potential to rescue CI defects, due to a possible competition with remaining CI activity, plant NDH-2 should be regarded with caution as potential therapeutic tools for human mitochondrial diseases.
Published: 2019
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30. An Optical Power Limiting and Ultrafast Photophysics Investigation of a Series of Multi-Branched Heavy Atom Substituted Fluorene Molecules

Author: Mikael Lindgren, Cyrille Monnereau, Chantal Andraud, Hampus Lundén, Jean Christophe Mulatier, Didrik K. Hopen, Pavel Chábera, Cesar Lopes, Iulia Minda, Adrien Liotta, Stephane Parola, Delphine Pitrat, Tõnu Pullerits, Swedish Defence Research Agency [Stockholm] (FOI), Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Chemical Physics and NanoLund, Lund University, Lund, Sweden, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Lund University [Lund]
Subjects: excited state absorption, Materials science, Atom and Molecular Physics and Optics, reverse saturable absorption, 02 engineering and technology, Fluorene, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, Photochemistry, 7. Clean energy, 01 natural sciences, Inorganic Chemistry, chemistry.chemical_compound, lcsh:Inorganic chemistry, Molecule, Moiety, optical power limiting, ultra-fast pump-probe spectroscopy, Spectroscopy, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Nanosecond, 021001 nanoscience & nanotechnology, lcsh:QD146-197, 0104 chemical sciences, Microsecond, Intersystem crossing, chemistry, Excited state, Atom- och molekylfysik och optik, 0210 nano-technology, ultra-fast pump–probe spectroscopy
Abstract: A common molecular design paradigm for optical power limiting (OPL) applications is to introduce heavy atoms that promote intersystem crossing and triplet excited states. In order to investigate this effect, three multi-branched fluorene molecules were prepared where the central moiety was either an organic benzene unit, para-dibromobenzene, or a platinum(II)&ndash, alkynyl unit. All three molecules showed good nanosecond OPL performance in solution. However, only the dibromobenzene and Pt&ndash, alkynyl compounds showed strong microsecond triplet excited state absorption (ESA). To investigate the photophysical cause of the OPL, especially for the fully organic molecule, photokinetic measurements including ultrafast pump&ndash, probe spectroscopy were performed. At nanosecond timescales, the ESA of the organic molecule was larger than the two with intersystem crossing (ISC) promoters, explaining its good OPL performance. This points to a design strategy where the singlet-state ESA is balanced with the ISC rate to increase OPL performance at the beginning of a nanosecond pulse.
Published: 2019
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31. Farm establishment, abandonment and agricultural practices during the last 1,300 years: a case study from southern Sweden based on pollen records and the LOVE model

Author: Anna Broström, Florence Mazier, Erik Daniel Fredh, Per Lagerås, Matts Lindbladh, Leif Björkman, Swedish National Heritage Board, Swedish National Heritage Board-Swedish National Heritage Board, Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Geobiosphere Science Centre, Lund University, Geobiosphere Science Centre, and Lund University [Lund]-Lund University [Lund]
Subjects: 010506 paleontology, Archeology, Climate change, Plant Science, Woodland, medicine.disease_cause, 01 natural sciences, Agricultural land, Pollen, medicine, 0601 history and archaeology, Charcoal, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, 060102 archaeology, business.industry, Abandonment (legal), Paleontology, 06 humanities and the arts, Vegetation, Geography, Agriculture, visual_art, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, visual_art.visual_art_medium, Physical geography, business
Abstract: The aim of the study was to identify changes in agricultural practices and periods of agricultural expansion and regression during the last 1,300 years in the South-Swedish Uplands. Sediments from the small lake of Skarpingsgolen (1.2 ha) were used to quantify land-cover at a local scale (c. 1 km radius) in 50-year intervals based on pollen analysis and the LOVE model (Local Vegetation Estimates). The results showed a dramatic change in land-cover, starting c. ad 1150, from a grazed, deciduous woodland, dominated by Corylus, Betula and Quercus, to a semi-open landscape dominated by Picea and open agricultural land. A hamlet, situated next to the lake, was probably established during the 12th century, abandoned during the late medieval crisis (late 14th century) and re-colonized during the 16th century. High values of Cannabis-type pollen (up to 10% of the pollen sum) suggest that hemp retting was carried out in the lake from the 13th to the 17th centuries, while elevated levels of microscopic charcoal indicate that slash-and-burn cultivation was practiced during the early 14th and the 16th–18th centuries. The LRA-based estimates of vegetation show that the modern landscape, dominated by managed coniferous woodlands, is very different from the landscape only 50–100 years ago. This type of study is useful for comparisons with historical and archaeological records, and provides sufficient temporal and spatial resolution to identify short-lived abandonments and shifts in agricultural practices.
Published: 2019
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32. Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

Author: Markus Otto, Henrik Zetterberg, Piotr Lewczuk, Oskar Hansson, Sylvain Lehmann, Clinical Memory Research Unit [Malmö, Suède], Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède]-Lund University [Malmö, Suède], Memory Clinic [Malmö, Suède], Skåne University Hospital [Malmö, Suède], Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Neurology [Ulm, Allemagne], Universität Ulm - Ulm University [Ulm, Allemagne], Clinical Neurochemistry Laboratory [Göteborg, Suède], Department of Psychiatry and Neurochemistry [Goteborg], Institute of Neuroscience and Physiology [Göteborg]-Sahlgrenska Academy at University of Gothenburg [Göteborg]-Institute of Neuroscience and Physiology [Göteborg]-Sahlgrenska Academy at University of Gothenburg [Göteborg], Department of Neurodegenerative Disease [Londres, Royaume-Uni], Institute of Neurology [London], University College of London [London] (UCL)-University College of London [London] (UCL), UK Dementia Research Institute (UK DRI), University College of London [London] (UCL), Department of Psychiatry and Psychotherapy [Erlangen, Allemagne], Universitätsklinikum Erlangen [Erlangen, Allemagne], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Department of Neurodegeneration Diagnostics [Bialystok, Pologne], Medical University of Bialystok [Bialystok, Pologne], Lab for Clinical Neurochemistry and Neurochemical Dementia Diagnostics [Erlangen, Allemagne], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Universitätsklinikum Erlangen [Erlangen, Allemagne], Fujirebio Europe sponsored this paper, however, it had no influence on its factual content. PL was supported by the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement n° 115372, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. OH has acquired research support (for the institution) from Roche, GE Healthcare, Biogen, AVID Radiopharmaceuticals, Fujirebio and Euroimmun. HZ’s research is supported by the Swedish Research Council, the European Research Council, the Knut and Alice Wallenberg Foundation, the Olav Thon Foundation, the UK Dementia Research Institute at UCL and Swedish State Support for Clinical Research (ALFGBG)., Lund University [Lund]-Lund University [Lund], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Medical University of Białystok (MUB), and Bodescot, Myriam
Subjects: 0301 basic medicine, Oncology, medicine.medical_specialty, Neurology, Amyloid β, Cognitive Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Diagnostic accuracy, Disease, Review, Aβ 42/40 ratio, Alzheimer's Disease, lcsh:RC346-429, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Medizinische Fakultät, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, ddc:610, Alzheimer’s Disease, Cognitive impairment, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biochemical markers, lcsh:Neurology. Diseases of the nervous system, Cerebrospinal Fluid, Amyloid beta-Peptides, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, business.industry, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.disease, Peptide Fragments, 030104 developmental biology, Aβ42/40 ratio, Neurology (clinical), business, 030217 neurology & neurosurgery, Amyloidβ Peptides, Biomarkers
Abstract: International audience; The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer's Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of Aβ42 to Aβ40 (Aβ42/40 Ratio) has been suggested to be superior to the concentration of Aβ42 alone when identifying patients with AD. This article reviews the available evidence on the use of the CSF Aβ42/40 ratio in the diagnosis of AD. Based on the body of evidence presented herein, it is the conclusion of the current working group that the CSF Aβ42/40 ratio, rather than the absolute value of CSF Aβ42, should be used when analysing CSF AD biomarkers to improve the percentage of appropriately diagnosed patients.
Published: 2019
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33. P-Tevolution of Precambrian eclogite in the Sveconorwegian orogen, SW Sweden

Author: Pavel Pitra, Charlotte Möller, Lorraine Tual, Department of geology, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund]-Lund University [Lund], Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), 61-1420/2010, Sveriges Geologiska Undersökning, 20110817, Crafoordska Stiftelsen, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, 010504 meteorology & atmospheric sciences, Continental crust, [SDU.STU.PE]Sciences of the Universe [physics]/Earth Sciences/Petrography, Geochemistry, Geology, 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Kyanite, Matrix (geology), Nappe, Precambrian, Tectonics, Geochemistry and Petrology, visual_art, visual_art.visual_art_medium, Baltica, Eclogite, 0105 earth and related environmental sciences
Abstract: International audience; Conditions of the prograde, peak-pressure and part of the decompressional P–T path of two Precambrian eclogites in the eastern Sveconorwegian orogen have been determined using the pseudosection approach. Cores of garnet from a Fe-Ti-rich eclogite sample record a first prograde and syn-deformational stage along a Barrovian geothermal gradient from ~670 °C and 7 kbar to 710 °C and 8.5 kbar. Garnet rims grew during further burial to 16.5-19 kbar at ~850-900 °C, along a steep dP/dT gradient. The pseudosection model of a kyanite-bearing eclogite sample of more magnesian bulk composition confirms the peak conditions. Matrix reequilibration associated with subsequent near-isothermal decompression and partial exhumation produced plagioclase-bearing symplectites replacing kyanite and clinopyroxene and is estimated at 850-870 °C and 10-11 kbar. The validity of the pseudosections is discussed in detail. It is shown that in pseudosection modelling the fractionation of FeO in accessory sulphides may cause a significant shift of field boundaries (here displaced by up to 1.5 kbar and 70 °C) and must not be neglected. Fast burial, exhumation and subsequent cooling are supported by the steepness of both the prograde and the decompressional P–T paths as well as the preservation of garnet growth zoning and the symplectitic reaction textures. These features are compatible with deep tectonic burial of the eclogite-bearing continental crust as part of the underthrusting plate (Eastern Segment, continent Baltica) in a collisional setting that led to an effectively doubled crustal thickness and subsequent exhumation of the eclogites through tectonic extrusion. Our results are in accordance with regional structural and petrological relationships, which demonstrate foreland-vergent partial exhumation of the eclogite-bearing nappe along a basal thrust zone and support a major collisional stage at c. 1 Ga. We argue that the similarities between Sveconorwegian and Himalayan eclogite occurrences emphasize the modern style of Grenvillian-aged tectonics.
Published: 2017
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34. Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Author: Luigi Mori, Sara González, Elia Grau, Dieter Niederacher, Alexandra C. Kölbl, Ares Solanes, Cassandra B. Nichols, Marine Guillaud-Bataille, Ulrike Schoenwiese, Katherine L. Nathanson, Alfons Meindl, Ellen Honisch, Hans Ehrencrona, Ute Enders, Anke Waha, Trinidad Caldés, Inge Søkilde Pedersen, Ana Blanco, Emma Tudini, Conxi Lázaro, Paolo Radice, Torben A Kruse, María Concepción Alonso-Cerezo, Chantal Farra, Shan Wang-Gohrke, Wilko Weichert, Heli Nevanlinna, Setareh Moghadasi, Bernd Auber, Carla Bruzzone, Aliana Guerrieri-Gonzaga, Sabine Grill, Raymonda Varon, Nicolas Derive, Ana Vega, Nicolai Maass, Åke Borg, Cora M. Aalfs, Nadia Naldi, Silvia Iglesias, Kai Ren Ong, Encarna B. Gomez Garcia, Karl Hackmann, Emma R. Woodward, Norbert Arnold, David E. Goldgar, Bernard Peissel, Karolin Bucksch, Berardino Porfirio, Françoise Révillion, Angel Izquierdo, Isabell Witzel, Sebastian Wagner, Silke Zachariae, Elisa Alducci, Mads Thomassen, Jesús del Valle, Valentina Zampiga, Kerstin Rhiem, Lidia Moserle, Edenir Inêz Palmero, Maaike P.G. Vreeswijk, Christoph Mundhenke, Laura Papi, Alejandro Moles-Fernández, Paula Rofes, Ulrike Faust, Andrea Gehrig, Sandrine M. Caputo, Logan C. Walker, Fiona Lalloo, Ute Felbor, Joan Brunet, Henriette Roed Nielsen, Sean V. Tavtigian, Beatrice Bortesi, Thomas Hansen, Maria Grazia Tibiletti, Estela Carrasco, Lisa Wiesmüller, Viviana Gismondi, Sophie Krieger, Pedro Pérez-Segura, Esther Pohl-Rescigno, Emanuela Lucci-Cordisco, Barbara Wappenschmidt, Rui Manuel Reis, Gabriele Lorenzo Capone, Ileana Carnevali, Christi J. van Asperen, KCon Fab Investigators, Jochen Seggewiß, Rhiannon J. Walters, Irmgard Debatin, Susan M. Domchek, Marco Montagna, Francesca Gensini, Kristiina Aittomäki, Véronique Dutrannoy, Arcangela De Nicolo, Giulia Cagnoli, Elisa J. Cops, Henrique de Campos Reis Galvão, Giulia Cini, Barbara Riboli, Eva Tornero, Paul A. James, Judith Balmaña, Anne-Marie Gerdes, Heide Hellebrand, Miriam Fine, Mathias Stiller, Aldo Germani, Diana Eccles, Britta Blümcke, Dominique Stoppa-Lyonnet, Elena Leinert, Alexandra Lewis, Daniela Rivera, Verena Hübbel, Fergus J. Couch, Gunnar Schmidt, Katharina Keupp, Bernhard H. F. Weber, Tilman Heinrich, Mariarosaria Calvello, Michael Dean, Udo Jeschke, Vanessa Lattimore, Linda A.M. Janssen, Siranoush Manoukian, Eva Gross, Kelly J. Sullivan, Doris Steinemann, Susanne Ledig, Alessandra Viel, Christoph Engel, Ana Sánchez de Abajo, Nina Ditsch, Sandra Bonache, Maria A. Caligo, Katharina Pfeifer, Thomas Haaf, Christian Sutter, Eric Hahnen, Laura Matricardi, Marc Tischkowitz, Alex Teulé, Katherine M. Tucker, Jutta Giesecke, Silvia Tognazzo, Gemma Montalban, Carolina Gómez, Anders Kvist, Joanna Lim, Alison H. Trainer, Rachel Susman, Judit Horvath, Amanda B. Spurdle, Mirjam Larsen, Therese Törngren, Mónica Salinas, Nicholas Pachter, Rachel Austin, Nicola K. Poplawski, C Zeder-Göß, Juliane Ramser, Julia Ritter, Anne Sophie Vesper, Paola Concolino, D. Gareth Evans, Clemens R. Müller, Matilde Navarro, Sara Torres-Esquius, Claus R. Bartram, Laura Cortesi, Jacopo Azzollini, Marion Harris, Edward M. Clarke, Marion Kiechle, Lídia Feliubadaló, Almuth Caliebe, Karen N. Herold, Charlotte Kvist Lautrup, Anne S. Quante, Gardenia Vargas-Parra, Michael T. Parsons, Pietro Cavalli, Hongyan Li, Rodrigo Augusto Depieri Michelli, Irene Feroce, Achim Wöckel, Kerstin Wieland, Silke Kaulfuß, Soo Hwang Teo, Angela Velasco, Capucine Delnatte, Marta Pineda, Marion van Mackelenbergh, Eva Montes, Angela Toss, Rita K. Schmutzler, William D. Foulkes, Alvaro N.A. Monteiro, Jan Hauke, Monica Marabelli, Miguel de la Hoya, Sara Gutiérrez-Enríquez, Esther Darder, Simona Agata, Amanda E. Toland, Bernardo Bonanni, Liliana Varesco, Orland Diez, Andreas Rump, Virginie Caux-Moncoutier, Gaetana Gambino, Markus Loeffler, Claude Houdayer, Elena Barbieri, Adrià López-Fernández, et. al., Universidade do Minho, QIMR Berghofer Medical Research Institute, Chinese Academy of Geological Sciences [Beijing] (CAGS), Ministry of Land and Resources (MLR), Department of Gynaecology and Obstetrics, University Hospital of Cologne [Cologne]-Centre of Familial Breast and Ovarian Cancer-Centre for Integrated Oncology (CIO), Programa de Càncer Hereditari, Unitat de Diagnòstic Molecular, Laboratori de Recerca Translacional, Institut Català d'Oncologia-IDIBELL, Department of Clinical Genetics, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Helsinki University Central Hospital, University Hospital of Schleswig-Holstein-Christian-Albrechts-Universität zu Kiel (CAU), Università degli Studi di Milano [Milano] (UNIMI), Medical Oncology Department, Vall d'Hebron University Hospital [Barcelona], Institute of Human Genetics, Universität Heidelberg [Heidelberg], Fundación Pública Galega de Medicina Xenómica-SERGAS & Grupo de Medicina Xenómica-USC, CIBER-ER, Division of Cancer Prevention and Genetics, Department of Oncology, Clinical Sciences, Lund University [Lund]-Skåne University Hospital, Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, Molecular Oncology Laboratory, Hospital Clínico San Carlos, Institut Curie [Paris], Programa de Consell Genètic en Càncer, Institut Català d'Oncologia, Girona-IdIBGi, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Centre René Gauducheau, CRLCC René Gauducheau, Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Oncogenetics Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Ludwig-Maximilians-Universität München (LMU), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Genetics, University of Southampton, Departament of Genetics and Pathology, Uppsala University-Rudbeck Laboratory, Department of Genomic Medicine, University of Manchester [Manchester], Department of Medical Genetics, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU)-Centre of Familial Breast and Ovarian Cancer, Obstetrics and Gynaecology, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Institüt für Humangenetik [Würzburg], Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Institute of Chemistry [Budapest], Faculty of Sciences [Budapest], Eötvös Loránd University (ELTE)-Eötvös Loránd University (ELTE), Service de Biochimie et de Biologie Moléculaire [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), I. Frauenklinik, Klinikum der Ludwig-Maximilians-Universitaet, Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Department of Oncology, Lund University [Lund]-Clinical Sciences, Genetic Medicine, Manchester Academic Health Sciences Centre-Central Manchester University Hospitals, Institute for Medical Informatics, Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale Tumouri (INT), Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, University Medical Center Kiel, Department of Obstetrics and Gynecology, University Hospital Düsseldorf-Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Medical Genetics Unit, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Department of Biochemistry, Section of Molecular Diagnostics, Laboratoire d'Oncologie Moléculaire Humaine, Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER, Institute of Cell and Molecular Pathology, Medizinische Hochschule Hannover (MHH), University of California [Santa Cruz] (UCSC), University of California, Heidelberg University Hospital [Heidelberg], International Agency for Cancer Research (IACR), Programa de Consejo Genético en Cáncer, Instituto Catalán de Oncología-IDIBELL, L'Hospitalet, Programa de Diagnòstic Molecular de Càncer Hereditari, Laboratori de Recerca Translacional, Institut Català d'Oncologia-IDIBELL, Hospital Duran i Reynals, Hospitalet de Llobregat, Unit of Hereditary Cancers, Istituto Nazionale per la Ricerca sul Cancro, CIBER de Enfermedades Raras (CIBERER), Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, University of Otago [Dunedin, Nouvelle-Zélande], Institute of Pathology, Department of Gynecology, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), King‘s College London, Molecular Diagnostic Unit, IDIBELL-Catalan Institute of Oncology, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumouri (INT)-Fondazione Istituto FIRC di Oncologia Molecolare, Institute for Medical Informatics, Statistics and Epidemiology [Leipzig] (IMISE), Universität Leipzig [Leipzig], Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, Clinical Center University of Cologne, Medicum, Research Programs Unit, Genome-Scale Biology (GSB) Research Program, Kristiina Aittomäki / Principal Investigator, HUSLAB, Department of Medical and Clinical Genetics, HUS Gynecology and Obstetrics, University Management, University of Helsinki, Università degli Studi di Milano = University of Milan (UNIMI), Universität Heidelberg [Heidelberg] = Heidelberg University, Department of Genetics and Pathology, Uppsala University, Julius-Maximilians-Universität Würzburg (JMU)-Centre of Familial Breast and Ovarian Cancer, Julius-Maximilians-Universität Würzburg (JMU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Firenze = University of Florence (UniFI), Université de Lille-UNICANCER-Université de Lille-UNICANCER, University of California [Santa Cruz] (UC Santa Cruz), University of California (UC), Universität Leipzig, University of Cologne, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Polikliniek (9), and Klinische Genetica
Subjects: Male, Multifactorial Inheritance, BRCA1, BRCA2, classification, clinical, multifactorial, quantitative, uncertain significance, variant, Alternative Splicing, BRCA1 Protein, BRCA2 Protein, Computational Biology, Early Detection of Cancer, Female, Genetic Predisposition to Disease, Humans, Likelihood Functions, Neoplasms, Mutation, Missense, Medicina Básica [Ciências Médicas], Settore MED/03 - GENETICA MEDICA, GUIDELINES, Genetic analysis, CLINGEN, SEQUENCE VARIANTS, Missense mutation, FUNCTIONAL ASSAYS, Genetics (clinical), BRCA1, BRCA2, quantitative, clinical, classification, multifactorial, variant, uncertain significance, 0303 health sciences, education.field_of_study, 030305 genetics & heredity, 1184 Genetics, developmental biology, physiology, SPLICING ANALYSIS, OVARIAN, BRCA2 Protein/genetics, 3. Good health, ddc, Mutation (genetic algorithm), Ciências Médicas::Medicina Básica, Medical genetics, Special Articles, medicine.medical_specialty, Posterior probability, Population, Computational biology, Biology, INTEGRATED EVALUATION, 03 medical and health sciences, Special Article, medicine, Genetics, BREAST-CANCER, Genetic variability, ddc:610, education, 030304 developmental biology, Tumors, Science & Technology, Proteins, Computational Biology/methods, RISKS, Mutation, BRCA1 Protein/genetics, 3111 Biomedicine, Missense, Proteïnes, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Genètica, Neoplasms/diagnosis
Abstract: The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification., Ohio State University Comprehensive Cancer Center Barretos Cancer Hospital. Grant Number: FINEP ‐ CT‐INFRA (02/2010) Breast Cancer Foundation of New Zealand Canadian Institutes of Health Research. Grant Number: PSR‐SIIRI‐701 Cancer Research UK. Grant Numbers: C8197/A16565, C5047/A8384, C1281/A12014, C12292/A11174, C1287/A10710, C1287/A10118, C1287/A16563, C5047/A10692, C5047/A15007 Department of Defence, USA. Grant Number: W81XWH‐10‐1‐0341 Helsinki University Hospital Research fund Scientific Foundation Asociación Española Contra el Cáncer Leiden University Medical Centre. Grant Number: Grant 30.925 Generalitat de Catalunya. Grant Numbers: PERIS_MedPerCan, URDCat, 2017SGR1282, 2017SGR496 Royal Society of New Zealand Cancer Council Victoria Netherlands Organization for Scientific Research (NWO). Grant Number: Grant 017.008.022 Breast Cancer Research Foundation Cancer Foundation of Western Australia EU H2020. Grant Number: 634935 Fundación Mutua Madrileña Seventh Framework Programme. Grant Numbers: 634935, 223175, 633784 Cancer Council South Australia Government of Galicia. Grant Number: Consolidation and structuring program: IN607B Cancer Council Tasmania Italian Association of Cancer Research. Grant Number: 15547 Queensland Cancer Fund AstraZeneca National Institute of Health (USA). Grant Numbers: 1U19 CA148065‐01, CA128978, CA192393, 1U19 CA148537, P50 CA1162091, CA116167, 1U19 CA148112 Newcastle University Dutch Cancer Society KWF. Grant Numbers: KWF/Pink Ribbon‐11704, UL2012‐5649 National Institute for Health Research. Grant Number: Manchester Biomedical Research centre (IS‐BRC‐1215 National Council of Technological and Scientific Development (CNPq) Instituto de Salud Carlos III. Grant Numbers: FIS PI15/00355, FIS PI13/01711, CIBERONC, FIS PI16/01218, PI16/00563 French National Institute of Cancer National Breast Cancer Foundation National Health and Medical Research Council. Grant Numbers: ID1061778, ID1104808 Carlos III National Health Centro de Investigación Biomédica en Red de Enferemdades Raras. Grant Number: ACCI 2016: ER17P1AC7112/2018 Cancer Council NSW Deutsche Krebshilfe. Grant Numbers: (#110837, #70111850 Fondazione Pisa. Grant Number: Grant “Clinical characterization of BRCA 1/2 Mis
Published: 2019
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35. Direct observation of aliphatic structures in soot particles produced in low-pressure premixed ethylene flames via online Raman spectroscopy

Author: Thomas Pino, Kim Cuong Le, Christophe Lefumeux, Per-Erik Bengtsson, Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Combustion Physics, Lund Institute of Technology, and Lund University [Lund]-Lund University [Lund]
Subjects: Ethylene, Materials science, Nanostructure, General Chemical Engineering, Nucleation, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, symbols.namesake, Phase (matter), medicine, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Mechanical Engineering, 021001 nanoscience & nanotechnology, Soot, 0104 chemical sciences, Aerosol, chemistry, 13. Climate action, symbols, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], 0210 nano-technology, Raman spectroscopy, Carbon
Abstract: Raman spectra of soot particles were monitored in the gaseous flow extracted from the burning regions of two low-pressure premixed ethylene flames, for the first time. The flame conditions were chosen to explore the diversity of soot nanostructure in slightly sooting flames. Evaluation of the Raman spectral parameters revealed that the soot particles exhibited a strongly disordered structure and a large proportion of sp hybridization of the carbon. The appearance of sp carbon chains composing up to 30% of the total carbon content as well as an olefinic component may indicate their important role in soot nucleation and growth in low pressure ethylene flames. Hence, Raman spectroscopy of soot particles in the aerosol phase revealed that accretion and cyclization of the aliphatic carbon including sp carbon chains could thus be of importance for the initial soot growth and require more investigation.
Published: 2019
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36. Adiabatic Elimination and Sub-space Evolution of Open Quantum Systems

Author: Ibrahim Saideh, Daniel Finkelstein-Shapiro, A. Keller, Thorsten Hansen, David Viennot, Tõnu Pullerits, Lund University [Lund], Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris Diderot - Paris 7 (UPD7), Université Paris-Saclay, Department of Chemistry [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), and Chemical Physics and NanoLund, Lund University, Lund, Sweden
Subjects: Density matrix, Trace (linear algebra), Atomic Physics (physics.atom-ph), Population, Degrees of freedom (statistics), FOS: Physical sciences, 01 natural sciences, 010305 fluids & plasmas, Physics - Atomic Physics, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Physics - Chemical Physics, 0103 physical sciences, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Statistical physics, 010306 general physics, Adiabatic process, education, ComputingMilieux_MISCELLANEOUS, Physics, Chemical Physics (physics.chem-ph), education.field_of_study, Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Detailed balance, Final value theorem, [SDU]Sciences of the Universe [physics], Quantum Physics (quant-ph), Subspace topology
Abstract: Efficient descriptions of open quantum systems can be obtained by performing an adiabatic elimination of the fast degrees of freedom and formulating effective operators for the slow degrees of freedom in reduced dimensions. Here, we perform the construction of effective operators in frequency space, and using the final value theorem or alternatively the Keldysh theorem, we provide a correction for the trace of the density matrix which takes into account the non trace-preserving character of the evolution. We illustrate our results with two different systems, ones where the eliminated fast subspace is constituted by a continuous set of states and ones with discrete states. Furthermore, we show that the two models converge for very large dissipation and at coherent population trapping points. Our results also provide an intuitive picture of the correction to the trace of the density matrix as a detailed balance equation., Comment: 12 pages, 9 figures, improved literature review
Published: 2019
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37. Raman spectroscopy of Mini-CAST soot with various fractions of organic compounds: structural characterization during heating treatment from 25 o C to 1000 o C

Author: Cuong Le, Kim, PINO, THOMAS, Pham, Van, Henriksson, Jonatan, Tӧrӧk, Sandra, Bengtsson, Erik, Pino, Thomas, Department of Combustion Physics, Lund Institute of Technology, Lund University [Lund]-Lund University [Lund], Institut des Sciences Moléculaires d'Orsay (ISMO), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI]Engineering Sciences [physics], [SPI] Engineering Sciences [physics], Raman spectroscopy, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], complex mixtures, soot, organic compounds, thermal treatment, [PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
Abstract: International audience; Soot particles undergo considerable changes in composition, morphology, as well as in internal structure during formation from the incipient particles to more mature aggregates, and still there is a lack of understanding of these mechanisms. In this study, soot produced by a mini-CAST soot generator was probed using Raman spectroscopy with focus on soot with large variation in size and fraction of organic compounds. The volatility of organic compounds and changes in internal bonding structures of the soot was surveyed by heating the samples from room temperature up to 1000 o C in a flow of inert N2 gas. The soot rich in organics showed more complex Raman spectra and stronger photoluminescence background. In particular, Raman signatures interpreted as the C-H "out-of-plane" mode, ethers CO -C, and carbonyl C=O groups were observed. During the heating treatment, these signatures disappeared, which was related to vaporization of the organics. Moreover, an enhancement of Raman band intensity of mature soot during heating treatment was observed for the first time. Our study thus brings new information on structural and compositional changes for soot during heating treatment in an inert atmosphere.
Published: 2019

38. 2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson’s disease

Author: Luc Bousset, Ivan G. Scheblykin, Daniela Täuber, Jia-Yi Li, Juanzi Shi, Christian Hansen, Ronald Melki, Rafael Camacho, Lund University [Lund], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Leibniz Institute of Photonic Technology (IPHT), Leibniz Association, Institute of Solid State Physics, FSU Jena (IFK), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Neuronal Survival Unit, BMC B11, Department of Experimental Medical Science, Department of Experimental Medical Sciences [Lund, Sweden], Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institute of Health Sciences, China Medical University, Shenyang, China, Chemical Physics and NanoLund, Lund University, Lund, Sweden, Department of Chemistry, KU Leuven, Leuven, Belgium, Centre National de la Recherche Scientifique (CNRS)-Service MIRCEN (MIRCEN), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: 0301 basic medicine, Parkinson's disease, Chemistry, Medicine (miscellaneous), Polarization imaging, medicine.disease, Fluorescence, Article, General Biochemistry, Genetics and Molecular Biology, nervous system diseases, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, lcsh:Biology (General), Biophysics, medicine, α synuclein, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, General Agricultural and Biological Sciences, lcsh:QH301-705.5, 030217 neurology & neurosurgery, Fluorescence anisotropy, Ex vivo, ComputingMilieux_MISCELLANEOUS
Abstract: A hallmark of Parkinson’s disease is the formation of large protein-rich aggregates in neurons, where α-synuclein is the most abundant protein. A standard approach to visualize aggregation is to fluorescently label the proteins of interest. Then, highly fluorescent regions are assumed to contain aggregated proteins. However, fluorescence brightness alone cannot discriminate micrometer-sized regions with high expression of non-aggregated proteins from regions where the proteins are aggregated on the molecular scale. Here, we demonstrate that 2-dimensional polarization imaging can discriminate between preformed non-aggregated and aggregated forms of α-synuclein, and detect increased aggregation in brain tissues of transgenic mice. This imaging method assesses homo-FRET between labels by measuring fluorescence polarization in excitation and emission simultaneously, which translates into higher contrast than fluorescence anisotropy imaging. Exploring earlier aggregation states of α-synuclein using such technically simple imaging method could lead to crucial improvements in our understanding of α-synuclein-mediated pathology in Parkinson’s Disease., Camacho et al. show detection of non-aggregated and aggregated α-synuclein in brain tissue from a mouse model of Parkinson’s disease using 2-dimensional polarization imaging. This fluorescence imaging method will allow for early detection of pathogenic α-synuclein aggregates associated with neurodegenerative illnesses.
Published: 2018
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39. MicroRNAs Are Involved in the Hypothalamic Leptin Sensitivity

Author: Derghal, Adel, Djelloul, Mehdi, Azzarelli, Myriam, Degonon, Sébastien, Tourniaire, Franck, Landrier, Jean-Francois, Mounien, Lourdes, Physiologie et physiopathologie du système nerveux somato-moteur et neurovégétatif (PPSN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU), Cell Stem Cell Laboratory for CNS Disease Modeling, Lund Stem Cell Center, Lund University [Lund]-Lund University [Lund], Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), PACA, CG13, Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre recherche en CardioVasculaire et Nutrition (C2VN)
Subjects: endocrine system, nervous system, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV]Life Sciences [q-bio], digestive, oral, and skin physiology, pro - opiomelanocortin, brown adipose tissue, hypothalamus, DICER, leptin, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, hormones, hormone substitutes, and hormone antagonists, micro RNA
Abstract: International audience; The central nervous system monitors modifications in metabolic parameters or hormone levels (leptin) and elicits adaptive responses such as food intake and glucose homeostasis regulation. Particularly, within the hypothalamus, pro-opiomelanocortin (POMC) neurons are crucial regulators of energy balance. Consistent with a pivotal role of the melanocortin system in the control of energy homeostasis, disruption of the Pomcgene causes hyperphagia and obesity. Pomcgene expression is tightly controlled by different mechanisms. Interestingly, recent studies pointed to a key role for microribonucleic acid (miRNAs) in the regulation of gene expression. However, the role of miRNAs in the leptin sensitivity in hypothalamic melanocortin system has never been assessed. We developed a transgenic mouse model (PDKO) with a partial deletion of the miRNA processing enzyme DICER specifically in POMC neurons. PDKO mice exhibited a normal body weight but a decrease of food intake. Interestingly, PDKO mice had decreased metabolic rate by reduction of VO2 consumption and CO2 production which could explain that PDKO mice have normal weight while eating less. Interestingly, we observed an increase of leptin sensitivity in the POMC neurons of PDKO mice which could explain the decrease of food intake in this model. We also observed an increase in the expression of genes involved in the function of brown adipose tissue that is in polysynaptic contact with the POMC neurons. In summary, these results support the hypothesis that Dicer-derived miRNAs may be involved in the effect of leptin on POMC neurons activity.
Published: 2018
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40. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Author: Yiallouros, Panayiotis K., Escobedo-de la Peña, Jorge, Zhou, Bin, Bentham, James, Di Cesare, Mariachiara, Bixby, Honor, Danaei, Goodarz, Hajifathalian, Kaveh, Taddei, Cristina, Carrillo-Larco, Rodrigo M., Djalalinia, Shirin, Khatibzadeh, Shahab, Lugero, Charles, Peykari, Niloofar, Zhang, Wan Zhu, Bennett, James, Bilano, Ver, Stevens, Gretchen A., Cowan, Melanie J., Riley, Leanne M., Chen, Zhengming, Hambleton, Ian R., Jackson, Rod T., Kengne, Andre Pascal, Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Malekzadeh, Reza, Neuhauser, Hannelore K., Sorić, Maroje, Starc, Gregor, Sundström, Johan, Woodward, Mark, Ezzati, Majid, Abarca-Gómez, Leandra, Abdeen, Ziad A., Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Noor Ani, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, Akhtaeva, Nazgul, Al-Raddadi, Rajaa, Ali, Mohamed M., Ali, Osman, Alkerwi, Ala'a, Aly, Eman, Amarapurkar, Deepak N., Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Ängquist, Lars H., Anjana, Ranjit Mohan, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assunção, Maria Cecília F., Avdicová, Mária, Azevedo, Ana, Azizi, Fereidoun, Babu, Bontha V., Bahijri, Suhad, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R., Barbagallo, Carlo M., Barceló, Alberto, Barkat, Amina, Barros, Aluisio J. D., Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Romdhane, Habiba Ben, Benet, Mikhail, Benson, Lowell S., Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Yufang, Bikbov, Mukharram, Bista, Bihungum, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Björkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boeing, Heiner, Boggia, Jose G., Boissonnet, Carlos P., Bongard, Vanina, Borchini, Rossana, Bovet, Pascal, Braeckman, Lutgart, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Bruno, Graziella, Bueno-de-Mesquita, H. B(as), Bugge, Anna, Burns, Con, Bursztyn, Michael, de León, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cameron, Christine, Can, Günay, Cândido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carlsson, Axel C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Cheng, Ching-Yu, Dekkaki, Imane Cherkaoui, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cinteza, Eliza, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., Cruz, Juan J., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Dankner, Rachel, Dantoft, Thomas M., Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Smedt, Delphine, Deepa, Mohan, Dehghan, Abbas, Delisle, Hélène, Deschamps, Valérie, Dhana, Klodian, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dickerson, Ty T., Do, Ha T. 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Donfrancesco, Chiara, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Doua, Kouamelan, Drygas, Wojciech, Dulskiene, Virginija, Džakula, Aleksandar, Dzerve, Vilni, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, El Ati, Jalila, Elliott, Paul, Elosua, Roberto, Erasmus, Rajiv T, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Evans, Alun, Faeh, David, Fall, Caroline H, Farzadfar, Farshad, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D, Fischer, Krista, Föger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fouad, Heba M, Francis, Damian K, do Carmo Franco, Maria, Franco, Oscar H, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Galvano, Fabio, Garcia-de-la-Hera, Manoli, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M, Ghasemian, Anoosheh, Ghimire, Anup, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Goldsmith, Rebecca A, Gonçalves, Helen, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gorbea, Mariano Bonet, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Grøntved, Ander, Grosso, Giuseppe, Gruden, Gabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idri, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Halkjær, Jytte, Hardy, Rebecca, Hari Kumar, Rachakulla, Hata, Jun, Hayes, Alison J, He, Jiang, He, Yuna, Elisabeth, Marleen, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Dinc, Gonul Horasan, Horimoto, Andrea R V R, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Than Htike, Maung Maung, Hu, Yonghua, Huerta, José María, Huisman, Martijn, Husseini, Abdullatif S, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G, Ibrahim, Mohsen M, Wong, Norazizah Ibrahim, Ikeda, Nayu, Ikram, M Arfan, Irazola, Vilma E, Islam, Muhammad, al-Safi Ismail, Aziz, Ivkovic, Vanja, Iwasaki, Masanori, Jacobs, Jeremy M, Jaddou, Hashem, Jafar, Tazeen, Jamrozik, Konrad, Janszky, Imre, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jeong, Seung-lyeal, Jiang, Chao Qiang, Joffres, Michel, Johansson, Mattia, Jokelainen, Jari J, Jonas, Jost B, Jørgensen, Torben, Joshi, Pradeep, Jóźwiak, Jacek, Juolevi, Anne, Jurak, Gregor, Jureša, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kajantie, Eero O, Kalter-Leibovici, Ofra, Kamaruddin, Nor Azmi, Karki, Khem B, Kasaeian, Amir, Katz, Joanne, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Boker, Lital Keinan, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kemper, Han C G, Kengne, Andre P, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khateeb, Mohammad, Khaw, Kay-Tee, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kim, Yeon-Yong, Klumbiene, Jurate, Knoflach, Michael, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Kowlessur, Sudhir, Koziel, Slawomir, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M, Kulaga, Zbigniew, Krishna Kumar, R, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Laatikainen, Tiina, Lachat, Carl, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Laugsand, Lars E, Le Nguyen Bao, Khanh, Le, Tuyen D, Leclercq, Catherine, Lee, Jeannette, Lee, Jeonghee, Lehtimäki, Terho, León-Muñoz, Luz M, Levitt, Naomi S, Li, Yanping, Lilly, Christa L, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lin, Xu, Lind, Lar, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Lorbeer, Roberto, Lotufo, Paulo A, Lozano, José Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L L, Machi, Suka, Maggi, Stefania, Magliano, Dianna J, Magriplis, Emmanuella, Majer, Marjeta, Makdisse, Marcia, Malhotra, Rahul, Mallikharjuna Rao, Kodavanti, Malyutina, Sofia, Manios, Yanni, Mann, Jim I, Manzato, Enzo, Margozzini, Paula, Marques-Vidal, Pedro, Marques, Larissa Pruner, Marrugat, Jaume, Martorell, Reynaldo, Mathiesen, Ellisiv B, Matijasevich, Alicia, Matsha, Tandi E, Mbanya, Jean Claude N, Mc Donald Posso, Anselmo J, McFarlane, Shelly R, McGarvey, Stephen T, McLachlan, Stela, McLean, Rachael M, McLean, Scott B, McNulty, Breige A, Mediene-Benchekor, Sounnia, Medzioniene, Jurate, Meirhaeghe, Aline, Meisinger, Christa, Menezes, Ana Maria B, Menon, Geetha R, Meshram, Indrapal I, Metspalu, Andre, Meyer, Haakon E, Mi, Jie, Mikkel, Kairit, Miller, Jody C, Minderico, Cláudia S, Francisco, Juan, Miranda, J Jaime, Mirrakhimov, Erkin, Mišigoj-Durakovic, Marjeta, Modesti, Pietro A, Mohamed, Mostafa K, Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Mohanna, Salim, Mohd Yusoff, Muhammad Fadhli, Møllehave, Line T, Møller, Niels C, Molnár, Déne, Momenan, Amirabba, Mondo, Charles K, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mota, Jorge, Esmaeel Motlagh, Mohammad, Motta, Jorge, Msyamboza, Kelias P, Mu, Thet Thet, Muiesan, Maria L, Müller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Musil, Vera, Nabipour, Iraj, Nagel, Gabriele, Naidu, Balkish M, Nakamura, Harunobu, Námešná, Jana, Nang, Ei Ei K, Nangia, Vinay B, Narake, Sameer, Nauck, Matthia, Navarrete-Muñoz, Eva Maria, Ndiaye, Ndeye Coumba, Neal, William A, Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Nguyen, Chung T, Nguyen, Nguyen D, Nguyen, Quang Ngoc, Nguyen, Quang V, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Noorbala, Ahmad Ali, Norat, Teresa, Noto, Davide, Al Nsour, Mohannad, O'Reilly, Dermot, Oda, Eiji, Oehlers, Glenn, Oh, Kyungwon, Ohara, Kumiko, Olinto, Maria Teresa A, Oliveira, Isabel O, Omar, Mohd Azahadi, Onat, Altan, Ong, Sok King, Ono, Lariane M, Ordunez, Pedro, Ornelas, Rui, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Overvad, Kim, Owusu-Dabo, Elli, Paccaud, Fred Michel, Padez, Cristina, Pahomova, Elena, Pajak, Andrzej, Palli, Domenico, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Panza, Francesco, Papandreou, Dimitrio, Park, Soon-Woo, Parnell, Winsome R, Parsaeian, Mahboubeh, Patel, Nikhil D, Pecin, Ivan, Pednekar, Mangesh S, Peer, Nasheeta, Peeters, Petra H, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peters, Annette, Petersmann, Astrid, Petkeviciene, Janina, Pham, Son Thai, Pigeot, Iri, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Plans-Rubió, Pedro, Polašek, Ozren, Porta, Miquel, Portegies, Marileen L P, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Prashant, Mathur, Price, Jacqueline F, Puder, Jardena J, Puiu, Maria, Punab, Margu, Qasrawi, Radwan F, Qorbani, Mostafa, Bao, Tran Quoc, Radic, Ivana, Radisauskas, Ricarda, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Ramachandra Rao, Sudha, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A, Redon, Josep, Reganit, Paul Ferdinand M, Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, Rinke de Wit, Tobias F, Ritti-Dias, Raphael M, Robinson, Sian M, Robitaille, Cynthia, Rodríguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, María, Rodríguez-Villamizar, Laura A, Rojas-Martinez, Rosalba, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Roy, Joel G R, Rubinstein, Adolfo, Sandra Ruiz-Betancourt, Blanca, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S, Saidi, Olfa, Sakarya, Sibel, Salanave, Benoit, Salazar Martinez, Eduardo, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Sans, Susana, Santos, Diana A, Santos, Ina S, Nunes dos Santos, Renata, Santos, Rute, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savva, Scazufca, Marcia, Schargrodsky, Herman, Schipf, Sabine, Schmidt, Carsten O, Schöttker, Ben, Schultsz, Constance, Schutte, Aletta E, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sharma, Sanjib K, Shaw, Jonathan E, Shibuya, Kenji, Shin, Dong Wook, Shin, Youchan, Si-Ramlee, Khairil, Siantar, Rosalynn, Sibai, Abla M, Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Skovbjerg, Sine, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C, Snijder, Marieke B, So, Hung-Kwan, Sobngwi, Eugène, Söderberg, Stefan, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild I A, Soric, Maroje, Jérome, Charles Sossa, Soumare, Aicha, Staessen, Jan A, Stathopoulou, Maria G, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Dori, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Shyong Tai, E, Tammesoo, Mari-Lii, Tamosiunas, Abdona, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Tautu, Oana-Florentina, Taylor, Anne, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thuesen, Betina H, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Torrent, Matie, Traissac, Pierre, Trichopoulos, Dimitrio, Trichopoulou, Antonia, Trinh, Oanh T H, Trivedi, Atul, Tshepo, Lechaba, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice E, Ulmer, Hanno, Uusitalo, Hannu M T, Valdivia, Gonzalo, Valvi, Damaskini, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, van Rossem, Lenie, Van Schoor, Natasja M, van Valkengoed, Irene G M, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lar, Vega, Toma, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Monique Verschuren, W M, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesu, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Sari, Wade, Alisha N, Wagner, Aline, Walton, Janette, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley, Rildo S, Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nichola, Wedderkopp, Niel, Weerasekera, Deepa, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wijga, Alet H, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Justin Y Y, Wong, Tien Yin, Woo, Jean, Giwercman Wu, Aleksander, Wu, Frederick C, Wu, Shouling, Xu, Haiquan, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yiallouros, Panayiotis K, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad Ali, Zambon, Sabina, Zampelas, Antoni, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Wei, Zheng, Yingfeng, Zhu, Dan, Zhussupov, Baurzhan, Zimmermann, Esther, Cisneros, Julio Zuñiga, The State Key Laboratory of Cell Biology [Shanghai, China] (CAS Center for Excellence in Molecular Cell Science), Shanghai Institute of Biochemistry and Cell Biology [Shanghai, China]-University of Chinese Academy of Sciences [Shanghai, China], Imperial College London, University of Kentucky, Middlesex University, Cleveland Clinic, Universidad Peruana Cayetano Heredia (UPCH), Brandeis University, Mulago Hospital [Kampala, Ouganda], Department of Epidemiology and Public Health, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), World Health Organisation (WHO), Al-Quds University, Discipline of Medicine, University of South Australia [Adelaide], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Centre for Industrial Management, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Institute of Preventive Medicine, Copenhagen University Hospitals, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Dept. Atherosclerose, University of Iceland [Reykjavik], Institute for Biotechnology and Bioengineering (IBB), Technical University of Lisbon, Medical University of Łódź (MUL), Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid (UAM), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Sunder Lal Jain Hospital, Ufa Eye Research Institute [Bashkortostan], National Institute of Public Health, Department of Epidemiology, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association-Leibniz Association, CHU Toulouse [Toulouse], Institute of Social and Preventive Medicine, Lausanne university hospital, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), ASU - School for Engineering of Matter, Transport and Energy, Arizona State University [Tempe] (ASU), Universidade do Porto = University of Porto, University of Oxford [Oxford], Cancer & Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), 2nd Department of Internal Medicine, Molecular Medicine, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-IRC KULAK, Department of Public Health, State University of Ghent, MRC Lifecourse Epidemiology Unit [Southampton, UK], University of Southampton, Réseau International des Instituts Pasteur (RIIP), Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Sahlgrenska University Hospital [Gothenburg], Institute of Metabolic Science, MRC, Institut National de Nutrition et de Technologie Alimentaire (INNTA), University of Huddersfield, IMIM-Hospital del Mar, Generalitat de Catalunya, Medstar Research Institute, Queen's University [Belfast] (QUB), Medical Research Council, Applied Sciences, National Research Institute on Food and Nutrition, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Infectious diseases division, Department of internal medicine, Washington University in Saint Louis (WUSTL), Innsbruck Medical University [Austria] (IMU), Department of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Laboratoire d'Etude des Mammifères Marins (LEMM), Océanopolis [Brest], Faculté de Médecine Henri Warembourg - Université de Lille, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark (SDU), Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Centro Investig Quim Aplicada, Coahuila, Mexico, Centro Investigacion en Quimica Aplicada, Coahuila, Mexico, University of Geneva [Switzerland], Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], Health Services Research Unit, Danish Cancer Society, Institute of Cancer Epidemiology, London School of Hygiene and Tropical Medicine (LSHTM), University College of London [London] (UCL), The Georges Institute for International Health, The University of Sydney, School of Information Technology, Deakin University Waurn Ponds, Faculté de Médecine, Université Djilali Liabès [Sidi-Bel-Abbès], Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), VU University Medical Center [Amsterdam], Universiteit Gent = Ghent University [Belgium] (UGENT), Faculty of Agricultural and Food Science, American University of Beirut [Beyrouth] (AUB), Åbo Akademi University [Turku], Department of Public Health Sciences, Karolinska Institutet [Stockholm], Great Lakes Institute for Environmental Research, University of Windsor [Ca], Universität Heidelberg [Heidelberg], Research Center for Prevention and Health, University of Ljubljana, Division of Cancer Epidemiology, University of Crete School of medicine, School of Public Health and Clinical Nutrition, University of Eastern Finland, Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Research Institute of Child Nutrition Dortmund, Rheinische Friedrich-Wilhelms-Universität Bonn, Cancer Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Oncology, University of Tampere Medical School, University of Tampere, Wageningen University and Research [Wageningen] (WUR), Centre for Environmental Health, National Institue of Public Health, School of Public Health, The University of Hong Kong (HKU), Tehran University of Medical Sciences, Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN), INRAN, National University of Singapore (NUS), Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Uppsala Universitet [Uppsala], Department of Public Health and Community Medicine, University of Gothenburg (GU), Institute of Earthquake Science, CEA, Beijing, CEA, Beijing, University of Porto Medical School, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Aging Program, National research council, Padua, Italy, Baker IDI Heart and Diabetes Institute, Institute of Internal Medicine, Russian Academy of Medical Sciences, Department of Nutrition and Dietetics, Harokopio University, Emory University [Atlanta, GA], Départment of Biotechnology, Faculty of Science, University of Oran Es-Senia [Oran] | Université d'Oran Es-Senia [Oran], Institut National de la Santé et de la Recherche Médicale (INSERM), University of Tartu, Department of Community, Université Ain Shams-Faculty of Medicine-Environmental and Occupational Medicine, Pécsi Tudemányegyetem, Department of Community, Environmental and Occupational Medicine, Université Ain Shams, Research Centre in Physical Activity, Health and Leisure, Nutrition and Metabolism Section, International Agency for Research on Cancer, Bushehr University of Medical Sciences, Institute of Epidemiology and Medical Biometry [Ulm, Allemagne], Universität Ulm - Ulm University [Ulm, Allemagne], Università degli studi di Palermo - University of Palermo, MRc Environmental Epidemiology Unit, Department of Cardiology and Department of Clinical Epidemiology, Aarhus University Hospital, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Department of Epidemiology and Population Studies, Jagiellonian University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Social Robotics Laboratory, University of Freiburg, Freiburg im Breisgau, Department of Ophthalmology, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, University of Bari Aldo Moro (UNIBA), Department of Cardiology, Eastbourne General Hospital, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), King‘s College London, Public Health Sciences, University of Edinburgh, Movement Disorders and Tourette Centre, Genetica medicala, Victor Babeş University of Medicine and Pharmacy (UMFT), Andrology Unit, United Laboratories of Tartu University Clinics, Tampere University Hospital, Department of Hygiene and Epidemiology, Dept of Epidemiology and Public Health, Department of Epidemiology and Biostatistics, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, Institut de Veille Sanitaire (INVS), Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain, parent, Department of Chronic Disease Prevention, National Institute for Health and Welfare [Helsinki], University of São Paulo (USP), Institut de Recherche pour le Développement (IRD [France-Sud]), Institute for plasma research, Institute for Plasma Research, Department of Biosciences and Nutrition, Department of Reproductive Endocrinology, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC - Academic medical center, Central Hospital and Faculty of medicine and biomedical sciences university, University of Yaoundé [Cameroun], Department of Clinical Sciences, Lund University [Lund]-Lund University Diabetes Centre, School of Computing [Leeds], University of Leeds, Copenhagen University Hospital, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maastricht University [Maastricht], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Applied Food Science, Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, University of Amsterdam, Dept. of Social Medecine, Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Africa Centre for Health and Population Studies, University of KwaZulu-Natal [Durban, Afrique du Sud] (UKZN)-Medical Research Council of South Africa, Center for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Department of Cardiovascular Sciences [Leuven], Cancer Epidemiology Institute, Department of Epidemiology and Health Promotion (MONICA Data Centre), National Public Health Institute, Nutrition et Alimentation des Populations aux Suds (NutriPass), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Havard School of Public Health, Dept of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens], University of Kuopio, Tampere University, University Medical Centre Utrecht, Department of Social Medicine, Amsterdam, Center for Metabolic Bone Diseases, Catholic University of Leuven, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Universidad Miguel Hernández [Elche] (UMH), Institute of Public Health and Clinical Nutrition [Kuopio, Finland], Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Division of Community Health Sciences, St George's University of London, Medizinische Universität Wien = Medical University of Vienna, Medical University of Silesia (SUM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), University of Innsbruck, National Institute of Hygiene Warsaw, Johns Hopkins University School of Medicine [Baltimore], Food Science and Technology, Beijing Forestry University, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics (CAE-NUAA), NUAA, Chinese Center for Disease Control and Prevention, Department of Applied Mathematics, School of Science, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, Siemens Corporate Research, Siemens AG [Munich], Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), This work was supported by the Wellcome Trust [101506/Z/13/Z]., NCD Risk Factor Collaboration (NCD-RisC). We thank WHO country and regional offices and the World Heart Federation for support in data identification and access., Universidad Autonoma de Madrid (UAM), University of Turin, Universidade do Porto, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Lille 2 - Faculté de Médecine, Westfälische Wilhelms-Universität Münster (WWU), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of KwaZulu-Natal (UKZN)-Medical Research Council of South Africa, Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Lund University Diabetes Centre-Lund University [Lund], Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Medical University of Silesia, Katowice, Apollo - University of Cambridge Repository, University of Kentucky (UK), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Lausanne University Hospital, University of Oxford, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Université de Genève = University of Geneva (UNIGE), Deakin University [Waurn Ponds], Universiteit Gent = Ghent University (UGENT), Universität Heidelberg [Heidelberg] = Heidelberg University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Universidade de São Paulo = University of São Paulo (USP), Lund University [Lund], Laboratoire Chrono-environnement (UMR 6249) (LCE), Leopold Franzens Universität Innsbruck - University of Innsbruck, National Institute of Public Health - National Institute of Hygiene [Poland], Yiallouros, Panayiotis K. [0000-0002-8339-9285], Giampaoli, Simona [0000-0002-6679-1488], Moschonis, George [0000-0003-3009-6675], Papandreou, Dimitrios [0000-0002-4923-484X], Stathopoulou, Maria G. [0000-0003-4376-2083], Stergiou, George S. [0000-0002-6132-0038], Trichopoulou, Antonia [0000-0002-7204-6396], Valvi, Damaskini [0000-0003-4633-229X], Chen, Z, Woodward, M, Key, T, and Smith, M
Subjects: systolic blood pressure, Settore MED/09 - Medicina Interna, blood pressure measurement, HEALTH EXAMINATION SURVEYS, Blood Pressure, Hypertension, Population Health, Global Health, Non-communicable Disease, Epidemiology, [SDV]Life Sciences [q-bio], global health, South Asia, purl.org/pe-repo/ocde/ford#3.03.09 [https], kohonnut verenpaine, Medicine and Health Sciences, middle income country, measurement method, skin and connective tissue diseases, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771, Public, Environmental & Occupational Health, adult, Population health, public health, blood pressure regulation, Public Health, Global Health, Social Medicine and Epidemiology, Non-communicable disease, kansainvälinen vertailu, health survey, aged, female, priority journal, Blood pressure, mean arterial pressure, GLOBAL TRENDS, SODIUM-INTAKE, Life Sciences & Biomedicine, survey design, hypertension, prevalence, Global health, UNITED-STATES, URBAN COMMUNITIES, Article, SECULAR TRENDS, Middle East, Central Asia, male, disease prevalence, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, kansanterveys, blood, SYSTEMATIC ANALYSIS, human, verenpainetauti, non-communicable disease, Science & Technology, Pacific Ocean, high income country, diastolic blood pressure, Pacific Rim, Blood Pressure - Epidemiology - Population, North Africa, major clinical study, HYPERTENSION PREVALENCE, verenpaine, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, ARTERIAL-HYPERTENSION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, POTASSIUM INTAKE, sense organs, trend analysis, trend study, population research, population health, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, low income country
Abstract: Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group-and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups., This work was supported by the Wellcome Trust [101506/Z/13/Z].
Published: 2018
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41. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Author: Sandra E. Black, M. Arfan Ikram, Charlotte Cordonnier, Sudha Seshadri, Paul M. Matthews, Vladimir Hachinski, Luciano A. Sposato, Jennifer Linn, Martin Dichgans, Robert J. van Oostenbrugge, Aad van der Lugt, David J. Werring, Anand Viswanathan, Joanna M. Wardlaw, François De Guio, Christophe Tzourio, Carol Brayne, Reinhold Schmidt, Richard H. Swartz, Leonardo Pantoni, Frank A. Wollenweber, Marco Duering, Bernard Mazoyer, Emrah Düzel, Fergus N. Doubal, Perminder S. Sachdev, Meike W. Vernooij, Franz Fazekas, John T. O'Brien, Blossom C. M. Stephan, Eric E. Smith, Carole Dufouil, Eric Jouvent, Hugues Chabriat, Geert J. Biessels, Vincent Mok, Bo Norrving, Stefan Ropele, Mark A. van Buchem, Christopher Chen, Frank Eric De Leeuw, De Guio, François, Génétique et Physiopathologie des Maladies Cérébro-Vasculaires (U1161 / UMR_S 1161), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), DHU NeuroVasc Sorbonne Paris-Cité, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [Lariboisière], AP-HP Groupe Hospitalier Lariboisière, Department of Neurology, VU University Medical Center [Amsterdam], Department of Medicine (Neurology), University of Toronto, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Pharmacology [Singapour], National University of Singapore (NUS)-Yong Loo Lin School of Medicine [Singapore], Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Neurology [Nijmegen], Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen]-Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen], Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), Munich Center for Systems Neurology (SyNergy), University of Edinburgh, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cognitive Neurology and Dementia Research [Magdeburg, Germany], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU)-Department of Cognitive Neurology and Dementia Research, Department of Neurology [Austria], Medical University Graz, Department of Clinical Neurological Sciences [London, Canada], University of Western Ontario (UWO), Departments of Radiology and of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Neurology [Rotterdam], Department of Neuroradiology [Munich], Klinikum Großhadern Munich - Hospital [Munich, Germany], Division of Brain Sciences [London], Imperial College London, Groupe d'Imagerie Neurofonctionnelle (GIN - UMR 5296), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Medicine and Therapeutics [Hong Kong], The Chinese University of Hong Kong [Hong Kong], Department of Clinical Sciences & Neurology [Lund, Sweden], Lund University [Lund], Department of Psychiatry [Cambridge, UK], NEUROFARBA Department [Firenze, Italy], Università degli Studi di Firenze = University of Florence (UniFI), Centre for Healthy Brain Ageing [Sydney], The University of Sydney, School of Computer Science [Manchester], University of Manchester [Manchester], Department of Neurology [Boston, USA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU)-Boston University [Boston] (BU), Department of Clinical Neurosciences and Hotchkiss Brain Institute [Calgary, Canada], University of Calgary, Institute of Health and Society [Newcastle, UK], Newcastle University, Campus for Aging and Vitality [Newcastle, UK], Department of Radiology [Leiden, The Netherlands], Leids Universitair Medisch Centrum [Leiden, The Netherlands], Department of Neurology [Maastricht, The Netherlands], Maastricht University Medical Centre - MUMC [Maastricht, The Netherlands], Glaucoma Research Unit [London], Moorfields Eye Hospital [London], Stroke Research Group [London, UK] (Department of Brain Repair and Rehabilitation), University of London - UCL [London, UK], Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), University of Edinburgh-Medical Research Council (MRC), CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U1171, Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Radboud University Medical Center [Nijmegen]-Donders Institute for Brain, Cognition and Behaviour, Radboud university [Nijmegen]-Radboud university [Nijmegen], Otto-von-Guericke University [Magdeburg] (OVGU)-Department of Cognitive Neurology and Dementia Research, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Lund University [Lund, Sweden], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Medical Research Council (MRC), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Epidemiology, Neurology, and Radiology & Nuclear Medicine
Subjects: Pathology, Neurology, [SDV]Life Sciences [q-bio], brain volume, Review, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Image Processing, Computer-Assisted, RATING-SCALE, Review Articles, WHITE-MATTER HYPERINTENSITY, reproducibility, lacunes, microbleeds, white matter hyperintensities, atrophy, marker, cerebral small vessel disease, Magnetic resonance imaging, repeatability, variability, perivascular spaces, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Brain, Hematology, MULTIPLE-SCLEROSIS, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], 3. Good health, ALZHEIMERS-DISEASE, [SDV] Life Sciences [q-bio], VIRCHOW-ROBIN SPACES, Brain size, Radiology, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, Clinical Neurology, MEASURING BRAIN ATROPHY, SURFACE-BASED ANALYSIS, 1102 Cardiovascular Medicine And Haematology, Endocrinology & Metabolism, 03 medical and health sciences, VOLUME CHANGES, Neuroimaging, medicine, Journal Article, Humans, GRADIENT NONLINEARITY CORRECTION, VASCULAR DEMENTIA, Vascular dementia, Reproducibility, Science & Technology, Neurology & Neurosurgery, business.industry, Multiple sclerosis, Neurosciences, Reproducibility of Results, 1103 Clinical Sciences, medicine.disease, Hyperintensity, Cerebral Small Vessel Diseases, Microvessels, Neurosciences & Neurology, Neurology (clinical), 1109 Neurosciences, business, Biomarkers, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Item does not contain fulltext Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
Published: 2016
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42. Mesures LIF résolues dans le temps du champ de température à l'intérieur d'une goutte au cours de l'impact sur une paroi chaude

Author: Romain Collignon, William Chaze, Ophélie Caballina, Guillaume Castanet, Fabrice Lemoine, CABALLINA, Ophélie, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Division of Combustion Physics, Lund Institute of Technology, and Lund University [Lund]-Lund University [Lund]
Subjects: [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, [SPI.MECA.THER]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Thermics [physics.class-ph], [SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], [SPI.FLUID] Engineering Sciences [physics]/Reactive fluid environment, ComputingMilieux_MISCELLANEOUS, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], [SPI.MECA.THER] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Thermics [physics.class-ph]
Abstract: International audience
Published: 2018

43. Titanium granules pre‑treated with hydrogen peroxide inhibit growth of bacteria associated with post‑operative infections in spine surgery

Author: Stéphane Corvec, Acke Ohlin, Julia R. Davies, Kristian Riesbeck, Pentti Tengvall, Gunnel Svensäter, Emma Mattsson, Matthias Mörgelin, Department of Clinical Sciences [Malmö, Sweden] ( Orthopaedics ), Lund University [Lund, Sweden], Department of Translational Medicine [Malmö, Sweden] ( Clinical Microbiology ), Department of Clinical Sciences [Lund, Sweden] ( Section of Infectious Medicine ), Department of Oral Biology [Malmö, Sweden] ( Faculty of Odontology ), Malmø University, Clinical and translational research in skin cancer ( CRCINA - Département INCIT - Equipe 2 ), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers ( CRCINA ), Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ) -Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ), Unité de bactériologie et d'hygiène [CHU Nantes] ( Institut de biologie ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Sahlgrenska Academy at University of Gothenburg [Göteborg], This work was supported by grants from the Anna and Edwin Berger Foundation, Medical Research Council (Grant Number K2015-57X-03163-43-4, www.vr.se) and Skåne County Council’s Research and Development Foundation., Department of Clinical Sciences [Malmö, Sweden] (Orthopaedics), Department of Translational Medicine [Malmö, Sweden] (Clinical Microbiology), Department of Clinical Sciences [Lund, Sweden] (Section of Infectious Medicine), Department of Oral Biology [Malmö, Sweden] (Faculty of Odontology), Clinical and Translational Research in Skin Cancer (CRCINA-ÉQUIPE 2), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Unité de bactériologie et d'hygiène [CHU Nantes] (Institut de biologie), Centre hospitalier universitaire de Nantes (CHU Nantes), Bernardo, Elizabeth, Lund University [Lund], Malmö Högskola = Malmö University, and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Subjects: Medicin och hälsovetenskap, Staphylococcus aureus, Prosthesis-Related Infections, Surface Properties, Klebsiella pneumoniae, [SDV.CAN]Life Sciences [q-bio]/Cancer, Microbial Sensitivity Tests, Growth, medicine.disease_cause, Medical and Health Sciences, Microbiology, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Parvimonas micra, Titanium, biology, Bacteria, business.industry, Pseudomonas aeruginosa, Prostheses and Implants, Antibiotic Prophylaxis, Staphylococcal Infections, biology.organism_classification, Antimicrobial, Hydrogen peroxide, Proteus mirabilis, Spine, Anti-Bacterial Agents, 3. Good health, Surgery, Anaerobic bacteria, business, 030217 neurology & neurosurgery, Titanium peroxy
Abstract: PURPOSE: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). METHODS: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria. RESULTS: Importantly, we found that the resulting Ti-peroxy was highly antimicrobial against all aerobic species tested, among others, Staphylococcus aureus and Pseudomonas aeruginosa. Proteus mirabilis was slightly more resistant than, for example, Klebsiella pneumoniae and enterococci. In contrast, anaerobic bacteria Cutibacterium acnes and Parvimonas micra were equally susceptible compared to staphylococci. CONCLUSIONS: Our findings suggest that the Ti-peroxy is a promising perioperative antimicrobial strategy that may be highly effective for prevention of post-operative infections. We therefore suggest application of hydrogen peroxide to implants prior to implantation. These slides can be retrieved under Electronic supplementary material.
Published: 2018
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44. Coulomb explosion imaging of CH3I and CH2CII photodissociation dynamics

Author: Barbara Cunha de Miranda, Per Johnsson, Romain Géneaux, Stuart R. Mackenzie, I. Ismail, Hansjochen Köckert, David M. P. Holland, Dimitrios Rompotis, Marie Géléoc, Jérôme Palaudoux, Loic Journel, Jonathan G. Underwood, Farzaneh Ziaee, Jan Lahl, Robert Mason, Kasra Amini, Mark Brouard, Gildas Goldsztejn, Artem Rudenko, Stefan Düsterer, Sylvain Maclot, Maria Novella Piancastelli, Arnaud Rouzée, Thierry Ruchon, Daniel Rolles, Michael Burt, Jongmin Lee, Rebecca Boll, Oksana Travnikova, Andrey S. Mereshchenko, Joss Wiese, Sebastian Trippel, Marc Simon, Francis Penent, Felix Allum, Felix Brauße, Bastian Manschwetus, Simone Techert, Evgeny Savelyev, Tatiana Marchenko, Henrik Stapelfeldt, Renaud Guillemin, Nora Schirmel, Cédric Bomme, Benjamin Erk, Alexander S. Gentleman, Claire Vallance, Pavel K. Olshin, Sadia Bari, Jochen Küpper, University of Oxford, Deutsches Elektronen-Synchrotron [Hamburg] (DESY), Saint Petersburg State Polytechnical University (SPSPU), KVI Atomic and Molecular Physics (KVI), University of Groningen [Groningen], Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (MBI), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Attophysique (ATTO), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique - Matière et Rayonnement (LCPMR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Microbiology Laboratory, Middlemore Hospital, Laboratoire des collisions atomiques et moléculaires (LCAM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Lund Institute of Technology, Lund University [Lund]-Lund University [Lund], Lund University [Lund], Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Physical and Theoretical Chemistry Laboratory, Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Kansas State University, Georg-August-University = Georg-August-Universität Göttingen, Department of Physics and Astronomy [UCL London], University College of London [London] (UCL), Center for Free-Electron Laser Science (CFEL), ANR-16-CE30-0001,ATTOMEMUCHO,Dynamique électronique attoseconde dans les molécules organiques isolées par la spectroscopie 'core-hole clock'(2016), University of Oxford [Oxford], Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Georg-August-University [Göttingen], Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Caen Normandie (UNICAEN), and Normandie Université (NU)
Subjects: Atom and Molecular Physics and Optics, Imaging spectrometer, General Physics and Astronomy, 02 engineering and technology, Physical Chemistry, 01 natural sciences, Molecular physics, Mass spectrometry imaging, Ion, 0103 physical sciences, Molecule, ddc:530, Physical and Theoretical Chemistry, 010306 general physics, ComputingMilieux_MISCELLANEOUS, Fysikalisk kemi, Physics, Coupling, Range (particle radiation), Photodissociation, Coulomb explosion, 021001 nanoscience & nanotechnology, 3. Good health, Atom- och molekylfysik och optik, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], 0210 nano-technology
Abstract: The journal of chemical physics 149(20), 204313 (2018). doi:10.1063/1.5041381, The photodissociation dynamics of CH$_3$I and CH$_2$ClI at 272 nm were investigated by time-resolved Coulomb explosion imaging, with an intense non-resonant 815 nm probe pulse. Fragment ion momenta over a wide m/z range were recorded simultaneously by coupling a velocity map imaging spectrometer with a pixel imaging mass spectrometry camera. For both molecules, delay-dependent pump-probe features were assigned to ultraviolet-induced carbon-iodine bond cleavage followed by Coulomb explosion. Multi-mass imaging also allowed the sequential cleavage of both carbon-halogen bonds in CH$_2$ClI to be investigated. Furthermore, delay-dependent relative fragment momenta of a pair of ions were directly determined using recoil-frame covariance analysis. These results are complementary to conventional velocity map imaging experiments and demonstrate the application of time-resolved Coulomb explosion imaging to photoinduced real-time molecular motion., Published by American Institute of Physics, Melville, NY
Published: 2018
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45. Habitat filtering determines the functional niche occupancy of plant communities worldwide

Author: Andrew Siefert, Marie Vandewalle, Bill Shipley, Riin Tamme, Marco Antônio Batalha, Kouki Hikosaka, Tohru Nakashizuka, Sarah J. Richardson, Vinícius de L. Dantas, Chiho Kamiyama, Marko J. Spasojevic, Stéphanie Gaucherand, Daniel C. Laughlin, Antonio Gazol, Yoann Le Bagousse-Pinguet, Mark Westoby, Nicolas Gross, Cédric Frenette Dussault, Christian Schöb, Jake McC. Overton, Takehiro Sasaki, Honor C. Prentice, Frédérique Louault, Ning Chen, Yuanzhi Li, Jodi N. Price, Vincent Jung, Marcus Vinicius Cianciaruso, Brandon S. Schamp, Masatoshi Katabuchi, Département de Biologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Université de Sherbrooke, State Key Laboratory of Grassland Agro-Ecosystem, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, China, School of Life Sciences [Chine], Département de Biologie, Sherbrooke University, School of Plant Biology, University of Western Australia, Perth, WA, Australia, The University of Western Australia (UWA), Institute for Land, Water and Society, Charles Sturt University, Albury, NSW, Australia, Charles Sturt University [Australia], Institute of Geography, Federal University of Uberlândia – UFU, Uberlândia, Brazil, Federal University of Uberlândia [Uberlândia] (UFU), Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia, University of Tartu, Evolution and Ecology Research Centre [UNSW Sydney], School of Biological, Earth and Environmental Sciences [Sydney] (BEES), University of New South Wales [Sydney] (UNSW)-University of New South Wales [Sydney] (UNSW), Dpt Biological Sciences, Macquarie University, Macquarie University, Department of Evolution and Ecology, University of California [Davis] (UC Davis), University of California-University of California, Department of Biology, Algoma University, Marie, OA, Canada, Algoma University [Canada], Department of Biology, University of California Riverside, Riverside, CA, USA, University of California [Riverside] (UCR), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Department of Botany, University of Wyoming, Laramie, WY, USA, University of Wyoming, Laramie, Landcare Research, Lincoln, New Zealand, Department of Botany, University of South Bohemia, University of South Bohemia, Área de Biodiversidad y Conservación, Departamento de Biología y Geología, Física y Química Inorgánica, Escuela Superior de Ciencias Experimentales y Tecnología, Universidad Rey Juan Carlos, Móstoles, Spain, Universidad Rey Juan Carlos [Madrid] (URJC), Institute of Evolutionary Biology and Environmental Studies, Zurich University, Instituto Pirenaico de Ecología (IPE-CSIC), Zaragoza, Spain, Department of Biology, Lund University, Lund, Sweden, Lund University [Lund, Sweden], Centre d'études biologiques de Chizé (CEBC), Centre National de la Recherche Scientifique (CNRS), INRA-CEBC, Institut National de la Recherche Agronomique (INRA), Landcare Research, Hamilton, New Zealand, Departamento de Ecologia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil, Universidade Federal de Goiás [Goiânia] (UFG), UR 0874 Unité de recherche sur l'Ecosystème Prairial, Institut National de la Recherche Agronomique (INRA)-Unité de recherche sur l'Ecosystème Prairial (UREP)-Ecologie des Forêts, Prairies et milieux Aquatiques (EFPA), Graduate School of Life Sciences, Tohoku University, Sendai, Japan, Tohoku University [Sendai], Department of Biology, Faculty of Science, Chiba University, Chiba, Japan, Chiba University [Japan], Department of Biology [Gainesville], University of Florida [Gainesville], Ecosystèmes montagnards (UR EMGR), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Lanzhou University, Department of Conservation Biology [UFZ Leipzig], Helmholtz Centre for Environmental Research (UFZ), Department of Botany, Federal University of São Carlos, São Carlos, Brazil, Federal University of São Carlos [Bresil], Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada, UOW1201, Royal Society of New Zealand, CZ.1.07/2.3.00/30.0006, European Social Fund, Czech State Budget, 563621/2010-9, CNPq/MCT/CAPES, 558187/2009-9, PELD/CNPq, 31270472, National Natural Science Foundation of China, PZ00P3_148261, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, 306843/2012-9, Conselho Nacional de Desenvolvimento Científico e Tecnológico, 2012102677001109, Fundação de Amparo à Pesquisa do Estado de Goiás, 656035, Horizon 2020 Framework Programme, 2010/01835-0, Fundação de Amparo à Pesquisa do Estado de São Paulo, Australian Research Council, China Scholarship Council, Département de biologie [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Université de Sherbrooke (UdeS), Algoma University, Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Manaaki Whenua – Landcare Research [Lincoln], Instituto Pirenaico de Ecologia (IPE), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Etudes Biologiques de Chizé [France] (USC 1339 INRA), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Department of Biology [Gainesville] (UF|Biology), University of Florida [Gainesville] (UF), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), European Project: 656035,H2020,H2020-MSCA-IF-2014,DRYFUN(2015), Vesk, Peter, University of California (UC)-University of California (UC), University of California [Riverside] (UC Riverside), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Lund University [Lund], Institut National de la Recherche Agronomique (INRA)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS), and Universidade Federal de São Carlos [São Carlos] (UFSCar)
Subjects: 0106 biological sciences, Occupancy, Niche, limiting similarity, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, Intraspecific competition, Limiting similarity, species richness, Life Below Water, Ecology, Evolution, Behavior and Systematics, Coexistence theory, Agricultural and Veterinary Sciences, Ecology, Null model, intraspecific trait variability, habitat filtering, 15. Life on land, Biological Sciences, determinants of plant community diversity and structure, Habitat, [SDE]Environmental Sciences, community assembly, Species richness, Environmental Sciences, niche occupancy, 010606 plant biology & botany
Abstract: [Departement_IRSTEA]Territoires [TR1_IRSTEA]SEDYVIN [ADD1_IRSTEA]Dynamique et fonctionnement des écosystèmes; International audience; How the patterns of niche occupancy vary from species-poor to species-rich communities is a fundamental question in ecology that has a central bearing on the processes that drive patterns of biodiversity. As species richness increases, habitat filtering should constrain the expansion of total niche volume, while limiting similarity should restrict the degree of niche overlap between species. Here, by explicitly incorporating intraspecific trait variability, we investigate the relationship between functional niche occupancy and species richness at the global scale. 2.We assembled 21 datasets worldwide, spanning tropical to temperate biomes and consisting of 313 plant communities representing different growth forms. We quantified three key niche occupancy components (the total functional volume, the functional overlap between species and the average functional volume per species) for each community, related each component to species richness, and compared each component to the null expectations. 3.As species richness increased, communities were more functionally diverse (an increase in total functional volume), and species overlapped more within the community (an increase in functional overlap) but did not more finely divide the functional space (no decline in average functional volume). Null model analyses provided evidence for habitat filtering (smaller total functional volume than expectation), but not for limiting similarity (larger functional overlap and larger average functional volume than expectation) as a process driving the pattern of functional niche occupancy. 4.Synthesis. Habitat filtering is a widespread process driving the pattern of functional niche occupancy across plant communities and coexisting species tend to be more functionally similar rather than more functionally specialized. Our results indicate that including intraspecific trait variability will contribute to a better understanding of the processes driving patterns of functional niche occupancy
Published: 2018
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46. Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study

Author: Deschasaux, Mélanie, Huybrechts, Inge, Murphy, Neil, Julia, Chantal, Hercberg, Serge, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Jenab, Mazda, Ward, Heather, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Kyrø, Cecilie, Olsen, Anja, Affret, Aurélie, Boutron-Ruault, Marie Christine, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Schwingshackl, Lukas, Bamia, Christina, Peppa, Eleni, Trichopoulou, Antonia, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Peeters, Petra H., Hjartåker, Anette, Rylander, Charlotta, Skeie, Guri, Ramón Quirós, J., Jakszyn, Paula, Salamanca-Fernández, Elena, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Sonestedt, Emily, Huseinovic, Ena, Johansson, Ingegerd, Khaw, Kay Tee, Wareham, Nick, Bradbury, Kathryn E., Perez-Cornago, Aurora, Tsilidis, Konstantinos K., Ferrari, Pietro, Riboli, Elio, Gunter, Marc J., Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition and Metabolism Section, International Agency for Research on Cancer, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health [London, UK] (Faculty of Medicine), Imperial College London, Department of Community Medicine, Faculty of Health Sciences, The Arctic University of Norway (UiT), Cancer Registry of Norway, Institute of Population-Based Cancer Research, Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], Genetic Epidemiology Group [Helsinki], Folkhälsan Research Center, Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki-Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Department of Public Health, Section for Epidemiology, Aarhus University [Aarhus], Danish Cancer Society Research Center, Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9)), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Gustave Roussy (IGR), Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Epidemiology, German Institute of Human Nutrition (DIfE), WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens]-University of Athens Medical School [Athens], Hellenic Health Foundation, Cancer Risk Factors and LifeStyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Cancer registry and histopathology unit, Civile - M.P.Arezzo Hospital, Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital-Center for Cancer Prevention (CPO-Piemonte), Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Department of Gastroenterology and Hepatology, University Medical Center [Utrecht], School of Public Health - Department of Epidemiology and Biostatistics, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Julius Center for Health Sciences and Primary Care, Department of Nutrition [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Public Health Directorate Asturias, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, L´Hospitallet de Llobregat, Facultat de Ciències de la Salut Blanquerna, Universitat Ramon Llull [Barcelona] (URL), Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Hospitales Universitarios de Granada/Universidad de Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Public Health Institute of Navarra, IdiSNA, Navarra Institute for Health Research, Public Health Department of Gipuzkoa, Diabetes and Cardiovascular disease, Genetic Epidemiology, Department of Clinical Sciences, Clinical Research Center, Lund University [Lund]-Lund University [Lund], Nutritional Epidemiology, Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy, University of Gothenburg (GU), Department of Odontology, Umeå University, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge [UK] (CAM), MRC Epidemiology Unit, Institute of Metabolic Science, Nuffield Department of Population Health - Cancer Epidemiology Unit, University of Oxford [Oxford], Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, French National Cancer Institute (INCa)-Canceropole Ile-de-France [2017-1-PL SHS-01-INSERM ADR 5-1], European Commission (DG-SANCO), Danish Cancer Society (Denmark), Ligue Contre le Cancer, (France), Institut Gustave Roussy, (France), Mutuelle Generale de l'Education Nationale, (France), Institut National de la Sante et de la Recherche Medicale (Inserm), (France), Deutsche Krebshilfe (Germany), Deutsches Krebsforschungszentrum (Germany), Federal Ministry of Education and Research (Germany), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Dutch Ministry of Public Health, Welfare, and Sports (VWS) (the Netherlands), Netherlands Cancer Registry (NKR) (the Netherlands), LK Research Funds (the Netherlands), Dutch Prevention Funds (the Netherlands), Dutch ZON (Zorg Onderzoek Nederland) (the Netherlands), World Cancer Research Fund (WCRF) (the Netherlands), Statistics Netherlands (the Netherlands), Health Research Fund (FIS) [PI13/00061], Regional Government of Andalucia (Spain), Regional Government of Asturias (Spain), Regional Government of Basque Country (Spain), Regional Government of Murcia (Spain) [6236], Regional Government of Navarra, ISCIII RETIC (Spain) [RD06/0020], Swedish Cancer Society (Sweden), Swedish Scientific Council (Sweden), County Council of Skane (Sweden), County Council of Vasterbotten (Sweden), Cancer Research UK [14136, C570/A16491, C8221/A19170], Medical Research Council [1000143, MR/M012190/1], National Research Council (Italy), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Hôpital avicenne, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne, Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Gustave Roussy (IGR), 'CIVIC-M.P. AREZZO' Hospital, University of Oxford, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR), Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Deschasaux, Mélanie [0000-0002-3359-420X], Huybrechts, Inge [0000-0003-3838-855X], Murphy, Neil [0000-0003-3347-8249], Hercberg, Serge [0000-0002-3168-1350], Srour, Bernard [0000-0002-1277-3380], Kesse-Guyot, Emmanuelle [0000-0002-9715-3534], Weiderpass, Elisabete [0000-0003-2237-0128], Dahm, Christina C [0000-0003-0481-2893], Kyrø, Cecilie [0000-0002-9083-8960], Olsen, Anja [0000-0003-4788-503X], Boutron-Ruault, Marie-Christine [0000-0002-5956-5693], Mahamat-Saleh, Yahya [0000-0002-5892-8886], Tumino, Rosario [0000-0003-2666-414X], Sacerdote, Carlotta [0000-0002-8008-5096], Hjartåker, Anette [0000-0003-3002-4030], Skeie, Guri [0000-0003-2476-4251], Jakszyn, Paula [0000-0003-0672-8847], Huerta, José María [0000-0002-9637-3869], Sonestedt, Emily [0000-0002-0747-4562], Johansson, Ingegerd [0000-0002-9227-8434], Wareham, Nick [0000-0003-1422-2993], Bradbury, Kathryn E [0000-0003-3345-7333], Perez-Cornago, Aurora [0000-0002-5652-356X], Riboli, Elio [0000-0001-6795-6080], Touvier, Mathilde [0000-0002-8322-8857], Apollo - University of Cambridge Repository, Deschasaux, Mélanie, Huybrechts, Inge, Murphy, Neil, Julia, Chantal, Hercberg, Serge, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Jenab, Mazda, Ward, Heather, Weiderpass, Elisabete, Dahm, Christina C, Overvad, Kim, Kyrø, Cecilie, Olsen, Anja, Affret, Aurélie, Boutron-Ruault, Marie-Christine, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Schwingshackl, Luka, Bamia, Christina, Peppa, Eleni, Trichopoulou, Antonia, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Ba, Peeters, Petra H, Hjartåker, Anette, Rylander, Charlotta, Skeie, Guri, Ramón Quirós, J, Jakszyn, Paula, Salamanca-Fernández, Elena, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Sonestedt, Emily, Huseinovic, Ena, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E, Perez-Cornago, Aurora, Tsilidis, Konstantinos K, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, and Touvier, Mathilde
Subjects: Adult, Male, [SDV.CAN]Life Sciences [q-bio]/Cancer, Nutrition Policy, Cohort Studies, Food Preferences, Medicine, General & Internal, project, Food Labeling, Risk Factors, front-of-package, su.vi.max cohort, General & Internal Medicine, Neoplasms, Humans, french adults, Prospective Studies, dietary index, database, Medicine(all), validation, Nutrition and Dietetics, Science & Technology, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, 11 Medical And Health Sciences, Middle Aged, Näringslära, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, Europe, prospective association, 3121 General medicine, internal medicine and other clinical medicine, Medicine, Female, cardiovascular-disease risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, Life Sciences & Biomedicine, Nutritive Value, france, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Source at https://doi.org/10.1371/journal.pmed.1002651. Background - Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling system to reflect the nutritional quality of food products. The Nutri-Score, a five-colour nutrition label, is derived from the Nutrient Profiling System of the British Food Standards Agency (modified version) (FSAm-NPS). How the consumption of foods with high/low FSAm-NPS relates to cancer risk has been studied in national/regional cohorts but has not been characterized in diverse European populations. Methods and findings - This prospective analysis included 471,495 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC, 1992–2014, median follow-up: 15.3 y), among whom there were 49,794 incident cancer cases (main locations: breast, n = 12,063; prostate, n = 6,745; colon-rectum, n = 5,806). Usual food intakes were assessed with standardized country-specific diet assessment methods. The FSAm-NPS was calculated for each food/beverage using their 100-g content in energy, sugar, saturated fatty acid, sodium, fibres, proteins, and fruits/vegetables/legumes/nuts. The FSAm-NPS scores of all food items usually consumed by a participant were averaged to obtain the individual FSAm-NPS Dietary Index (DI) scores. Multi-adjusted Cox proportional hazards models were computed. A higher FSAm-NPS DI score, reflecting a lower nutritional quality of the food consumed, was associated with a higher risk of total cancer (HRQ5 versus Q1 = 1.07; 95% CI 1.03–1.10, P-trend < 0.001). Absolute cancer rates in those with high and low (quintiles 5 and 1) FSAm-NPS DI scores were 81.4 and 69.5 cases/10,000 person-years, respectively. Higher FSAm-NPS DI scores were specifically associated with higher risks of cancers of the colon-rectum, upper aerodigestive tract and stomach, lung for men, and liver and postmenopausal breast for women (all P < 0.05). The main study limitation is that it was based on an observational cohort using self-reported dietary data obtained through a single baseline food frequency questionnaire; thus, exposure misclassification and residual confounding cannot be ruled out. Conclusions - In this large multinational European cohort, the consumption of food products with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher risk of cancer. This supports the relevance of the FSAm-NPS as underlying nutrient profiling system for front-of-pack nutrition labels, as well as for other public health nutritional measures.
Published: 2018
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47. Historical TOC concentration minima during peak sulfur deposition in two Swedish lakes

Author: Dan Hammarlund, Anna Broström, Daniel Fredh, Anne Birgitte Nielsen, Peter Rosén, Wilhelm Granéli, Petra Bragée, Florence Mazier, Department of Geology, Quaternary Sciences, Lund University [Lund], Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Department of biology and environmental sciences, Umeå University, Department of Geology, Lund University [Lund]-Lund University [Lund], and Department of Biology
Subjects: lcsh:Life, Climate change, chemistry.chemical_element, Forcing (mathematics), lcsh:QH540-549.5, Precipitation, lake, Ecology, Evolution, Behavior and Systematics, Earth-Surface Processes, Sweden, Ekologi, Hydrology, Total organic carbon, Ecology, biology, lcsh:QE1-996.5, Historical TOC, Sediment, [SHS.GEO]Humanities and Social Sciences/Geography, biology.organism_classification, Sulfur, lcsh:Geology, lcsh:QH501-531, Diatom, chemistry, Boreal, Environmental science, Physical geography, lcsh:Ecology
Abstract: Decadal-scale variations in total organic carbon (TOC) concentration in lake water since AD 1200 in two small lakes in southern Sweden were reconstructed based on visible–near-infrared spectroscopy (VNIRS) of their recent sediment successions. In order to assess the impacts of local land-use changes, regional variations in sulfur, and nitrogen deposition and climate variations on the inferred changes in TOC concentration, the same sediment records were subjected to multi-proxy palaeolimnological analyses. Changes in lake-water pH were inferred from diatom analysis, whereas pollen-based land-use reconstructions (Landscape Reconstruction Algorithm) together with geochemical records provided information on catchment-scale environmental changes, and comparisons were made with available records of climate and population density. Our long-term reconstructions reveal that inferred lake-water TOC concentrations were generally high prior to AD 1900, with additional variability coupled mainly to changes in forest cover and agricultural land-use intensity. The last century showed significant changes, and unusually low TOC concentrations were inferred at AD 1930–1990, followed by a recent increase, largely consistent with monitoring data. Variations in sulfur emissions, with an increase in the early 1900s to a peak around AD 1980 and a subsequent decrease, were identified as an important driver of these dynamics at both sites, while processes related to the introduction of modern forestry and recent increases in precipitation and temperature may have contributed, but the effects differed between the sites. The increase in lake-water TOC concentration from around AD 1980 may therefore reflect a recovery process. Given that the effects of sulfur deposition now subside and that the recovery of lake-water TOC concentrations has reached pre-industrial levels, other forcing mechanisms related to land management and climate change may become the main drivers of TOC concentration changes in boreal lake waters in the future.
Published: 2015
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48. Unravelling a HP-HT progrademetamorphic history from quartzand rutile inclusions in garnet

Author: Tual, Lorraine, Möller, C., Pitra, Pavel, Whitehouse, Martin, Department of geology, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund]-Lund University [Lund], Laboratory for Isotope Geology, Swedish Museum of Natural History (NRM), Géosciences Rennes (GR), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Dubigeon, Isabelle, Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), and Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.STU.PE]Sciences of the Universe [physics]/Earth Sciences/Petrography, [SDU.STU.PE] Sciences of the Universe [physics]/Earth Sciences/Petrography
Abstract: International audience; Trace-element compositions of mineral inclusions ingarnet (e.g., quartz, zircon and rutile) are commonly used toprovide thermo(baro)metric estimates. However, thesystematics of the thermometric equilibria in these minerals athigh pressure and temperature are not fully understood. Toinvestigate this, we analyzed in-situ quartz and rutileinclusions in a Fe-Ti-rich eclogite from the Sveconorwegianorogen in southern Sweden by SIMS. Abundant quartz, rutileand zircon in distinct microstructural sites (garnet core, garnetrims and matrix) make this sample particularly suitable forthis study.A P–T path, peaking at 16.5–19 kbar and 850–900 °C hasbeen deduced for this rock by pseudosection modelling; inputpressures from this model were used for trace elementthermometry of each garnet microtextural domain. For garnetcores, Zr-in-rutile yields 700–715 °C and Ti-in-quartz 620–640 °C at 7 kbar. For garnet rims, temperature estimates are760–790 °C (Zr-in-rutile) and 740–890 °C (Ti-in-quartz) at12–18 kbar. Finally, matrix rutile records 775–800 °C andlocally ~900 °C, and quartz records temperatures up to ~890°C. Alongside, direct combination of Ti in quartz and Zr inrutile isopleths yields a prograde path that is nearly identicalto that deduced from the pseudosection.The pseudosection shows that rutile was produced bycontinuous breakdown of ilmenite during the early stages ofprograde metamorphism – a reaction that was completed at~730 °C. Thereafter, rutile grains in the garnet rim and thematrix grew larger by recrystallization. However, these rutilegrains generally do not record the peak-P temperatures, butinstead yield 775–815 °C. This is interpreted to reflectrecrystallization associated with a major progradedehydration reaction in the rock, involving continuousbreakdown of hornblende and production of clinopyroxene.This study illustrates that Zr-in-rutile and Ti-in-quartzthermobarometry can robustly constrain prograde P–Tconditions and also yield important insights onrecrystallization processes at high temperatures. Thecombination of these methods and integration of the resultswith pseudosection modelling provides a versatile tool forinvestigating the petrologic history of high-grade rocks.
Published: 2017

49. Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Author: Astrid Murumägi, Sara Ek, Caroline A. Heckman, Hanna Karvonen, Daniela Ungureanu, Wilhelmiina Niininen, Matti Nykter, Elaheh Moradi, Mats Jerkeman, David Chiron, Olli Kallioniemi, BioMediTech Institute [Tampere], University of Tampere [Finland], Faculty of Medicine and Life Sciences [Tampere], Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Department of Immunotechnology - Faculty of Engineering [Lund, Sweden], Lund University [Lund, Sweden]-Institute of Clinical Sciences [Lund, Sweden], Department of Oncology and Pathology [Lund], Lund University [Lund], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Science for Life Laboratory [Solna], Royal Institute of Technology [Stockholm] (KTH ), This work was supported by the Doctoral Programme in Biomedicine and Biotechnology at University of Tampere, Academy of Finland, Center of Excellence for Translational Cancer Biology, and the Sigrid Juselius Foundation., Bernardo, Elizabeth, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Lund University [Lund]-Institute of Clinical Sciences [Lund, Sweden], and Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Subjects: 0301 basic medicine, medicine.medical_treatment, Chronic lymphocytic leukemia, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pharmacology, Receptor tyrosine kinase, Targeted therapy, 03 medical and health sciences, chemistry.chemical_compound, [SDV.CAN] Life Sciences [q-bio]/Cancer, immune system diseases, hemic and lymphatic diseases, medicine, Bruton's tyrosine kinase, Orphan receptor, Lymphoid Neoplasia, biology, Hematology, medicine.disease, 3. Good health, 030104 developmental biology, chemistry, Ibrutinib, ROR1, biology.protein, Cancer research, Mantle cell lymphoma
Abstract: International audience; Key Points • Targeting ROR1 downregulates NF-kB p65 expression and sensitizes MCL cells to BCR-or Bcl-2–targeted drugs. • Inhibition of BCR signaling by BTK-specific inhibitors such as ibrutinib impairs ROR1 levels and consecutively ROR1-targeted therapies. Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin B-cell lymphoma with poor prognosis due to drug resistance. Introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has markedly improved MCL therapy outcome, but drug resistance remains a challenge. The selective cell-surface expression of oncogenic receptor tyrosine kinase–like orphan receptor 1 (ROR1) pseudokinase in hematological malignancies has made this receptor a promising candidate for targeted therapy. We sought to identify the molecular mechanism underlying divergent ROR1-mediated apoptotic responses in MCL cell lines and primary samples. We show that targeting ROR1 expression resulted in downregulation of NF-kB p65 levels and that activation of the NF-kB pathway can antagonize ROR1-mediated apoptotic responses. High-throughput drug-sensitivity testing of MCL cells before and after ROR1 targeting revealed synergistic effects between cotargeting of ROR1 and the B-cell antigen receptor (BCR) or Bcl-2 family, underlining the high potential for ROR1-targeted therapies in overcoming MCL drug resistance. However, inhibition of the BCR pathway by targeted drugs such as ibrutinib can impair ROR1 expression and consequently ROR1-targeted treatments, underscoring the importance of inhibiting both pathways to augment cancer cell killing. Considering the central role of NF-kB pathway activation in B-cell malignancies, this study highlights key factors that can modulate
Published: 2017
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50. The Role of MicroRNA in the Modulation of the Melanocortinergic System

Author: Derghal, Adel, Djelloul, Mehdi, Trouslard, Jérôme, Mounien, Lourdes, Physiologie et physiopathologie du système nerveux somato-moteur et neurovégétatif (PPSN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU), Cell Stem Cell Laboratory for CNS Disease Modeling, Lund Stem Cell Center, Lund University [Lund]-Lund University [Lund], and Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)
Subjects: endocrine system, nervous system, microRNA, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, digestive, oral, and skin physiology, feeding behavior, melanocortin, hypothalamus, energy homeostasis, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, hormones, hormone substitutes, and hormone antagonists, Neuroscience
Abstract: International audience; The central control of energy balance involves a highly regulated neuronal network within the hypothalamus and the dorsal vagal complex. In these structures, pro-opiomelanocortin (POMC) neurons are known to reduce meal size and to increase energy expenditure. In addition, leptin, a peripheral signal that relays information regarding body fat content, modulates the activity of melanocortin pathway neurons including POMC-, Agouti-related peptide (AgRP)/Neuropeptide Y (NPY)-, melanocortin receptors (MC3R and MC4R)-expressing neurons. MicroRNAs (miRNAs) are short non-coding RNAs of 22–26 nucleotides that post-transcriptionally interfere with target gene expression by binding to their mRNAs. Evidence has demonstrated that miRNAs play important roles in the central regulation of energy balance. In this context, different studies identified miRNAs including miR-200 family, miR-103, or miR-488 that could target the genes of melanocortin pathway. More precisely, these different miRNAs can modulate energy homeostasis by affecting leptin transduction pathway in the POMC, or AgRP/NPY neurons. This article reviews the role of identified miRNAs in the modulation of melanocortin pathway in the context of energy homeostasis.
Published: 2017
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