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14. 'Working me to life': longitudinal perceptions from adults with heart failure with preserved ejection fraction enrolled in an exercise training clinical trial.

Author

Salahshurian, Erin, Pozehl, Bunny J, Lundgren, Scott W, Bills, Sara, Pandey, Ambarish, Carbone, Salvatore, and Alonso, Windy W

Subjects
INJURY risk factors, HEART failure treatment, PATIENT compliance, HEALTH services accessibility, FEAR, WOUNDS & injuries, VENTRICULAR ejection fraction, QUALITATIVE research, SECONDARY analysis, EXERCISE therapy, HEALTH, INTERVIEWING, TREATMENT effectiveness, HEART failure, RANDOMIZED controlled trials, DESCRIPTIVE statistics, INFORMATION resources, MENTORING, THEMATIC analysis, MOTIVATION (Psychology), RESEARCH methodology, QUALITY of life, FINANCIAL management, TRANSPORTATION of patients, SYMPTOMS
Abstract

Aims Adults with heart failure with preserved ejection fraction (HFpEF) responded more favourably to an exercise intervention compared with those with reduced ejection fraction. This study explores factors that contributed to this response, focusing on the qualitative perceptions of adults with HFpEF enrolled in an exercise intervention. Methods and results This qualitative descriptive study is a secondary analysis of longitudinal interviews collected at 3, 6, 12, and 18 months from participants with HFpEF enrolled in a randomized controlled trial testing an intervention to promote adherence to exercise. We included participants with at least two interviews. Interviews were examined across and within participants and time points using thematic analysis. Analyses included 67 interviews from 21 adults with HFpEF enrolled in the intervention arm. The sample consisted of 52% (11/21) males and over 47% (10/21) non-White participants. Mean age at enrolment was 63.7 ± 9.9 years. We identified four major themes: (1) overcoming negative attitudes, barriers, and injury, (2) motivations to exercise, (3) exercise—the panacea for HFpEF symptoms and quality of life, and (4) advice for others with HFpEF. Conclusion Our findings suggest that for many adults with HFpEF, initial hesitancy, fear, and negative attitudes about exercise can be overcome. Exercise coaching using social cognitive constructs, medical fitness centre memberships, and heart rate self-monitoring are successful strategies of engaging adults with HFpEF in long-term unsupervised exercise training. Registration ClinicalTrials.gov , NCT01658670. [ABSTRACT FROM AUTHOR]

Published
2024
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33. sj-docx-1-jao-10.1177_03913988221112684 – Supplemental material for Impact of digoxin utilization on clinical outcomes following left ventricular assist device implantation

Author

Abbasi, Muhannad Aboud, Stoller, Douglas A, Lyden, Elizabeth, Lowes, Brian D, Zolty, Ronald, and Lundgren, Scott W

Subjects
FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-jao-10.1177_03913988221112684 for Impact of digoxin utilization on clinical outcomes following left ventricular assist device implantation by Muhannad Aboud Abbasi, Douglas A Stoller, Elizabeth Lyden, Brian D Lowes, Ronald Zolty and Scott W Lundgren in The International Journal of Artificial Organs

Published
2022
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46. A Comprehensive Review of Mechanical Circulatory Support Devices.

Author

Atti, Varunsiri, Narayanan, Mahesh Anantha, Patel, Brijesh, Balla, Sudarshan, Siddique, Aleem, Lundgren, Scott, and Velagapudi, Poonam

Subjects
ARTIFICIAL blood circulation, CARDIAC catheterization, INTRA-aortic balloon counterpulsation, HEART assist devices, CARDIOGENIC shock, HEMODYNAMICS, PULMONARY artery catheters
Abstract

Treatment strategies to combat cardiogenic shock (CS) have remained stagnant over the past decade. Mortality rates among patients who suffer CS after acute myocardial infarction (AMI) remain high at 50%. Mechanical circulatory support (MCS) devices have evolved as novel treatment strategies to restore systemic perfusion to allow cardiac recovery in the short term, or as durable support devices in refractory heart failure in the long term. Haemodynamic parameters derived from right heart catheterization assist in the selection of an appropriate MCS device and escalation of mechanical support where needed. Evidence favouring the use of one MCS device over another is scant. An intra-aortic balloon pump is the most commonly used short-term MCS device, despite providing only modest haemodynamic support. Impella CP® has been increasingly used for CS in recent times and remains an important focus of research for patients with AMI-CS. Among durable devices, Heartmate® 3 is the most widely used in the USA. Adequately powered randomized controlled trials are needed to compare these MCS devices and to guide the operator for their use in CS. This article provides a brief overview of the types of currently available MCS devices and the indications for their use. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member

Author

Callahan, Christopher A., Muralidhar, M.G., Lundgren, Scott E., Scully, Audra L., and Thomas, John B.

Subjects
Drosophila -- Genetic aspects, Developmental neurology -- Research, Proteins -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The derailed (drl) gene present in Drosophila encodes the receptor protein-tyrosine kinase Drl which probably controls the selection of pathways by the developing neurons after activation by its ligand. This control is by the regulation of cell adhesion molecules which control the proper fasciculation of axons. The drl gene is expressed in a subset of embryonic interneurons whose growth cones choose similar pathways. These neurons in drl deficient individuals are unable to choose the correct pathways. The Drl protein is similar in structure to the mammalian RYK protein.

Published
1995

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