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15 results on '"Luo, Guijuan"'

4. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma

Author

Li, Liang, Chen, Jianguo, Chen, Xin, Tang, Jing, Guo, Huan, Wang, Xiaofeng, Qian, Ji, Luo, Guijuan, He, Fangping, Lu, Xiaomei, Ding, Yibo, Yang, Yingchen, Huang, Wentao, Hou, Guojun, Lin, Ximeng, Ouyang, Qin, Li, Hengyu, Wang, Ruoyu, Jiang, Feng, Pu, Rui, Lu, Jianhua, Jin, Mudan, Tan, Yexiong, Gonzalez, Frank J., Cao, Guangwen, Wu, Mengchao, Wen, Hao, Wu, Tangchun, Jin, Li, Chen, Lei, and Wang, Hongyang

Published
2016
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5. Discovery of a Carbamoyl Phosphate Synthetase 1–Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis

Author

Wu, Tong, primary, Luo, Guijuan, additional, Lian, Qiuyu, additional, Sui, Chengjun, additional, Tang, Jing, additional, Zhu, Yanjing, additional, Zheng, Bo, additional, Li, Zhixuan, additional, Zhang, Yani, additional, Zhang, Yangqianwen, additional, Bao, Jinxia, additional, Hu, Ji, additional, Shen, Siyun, additional, Yang, Zhao, additional, Wu, Jianmin, additional, Wang, Kaiting, additional, Zhao, Yan, additional, Yang, Shuai, additional, Wang, Shan, additional, Qiu, Xinyao, additional, Wang, Wenwen, additional, Wu, Xuan, additional, Wang, Hongyang, additional, Gu, Jin, additional, and Chen, Lei, additional

Published
2021
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7. A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection

Author

Jeong, Seogsong, primary, Luo, Guijuan, additional, Gao, Qiang, additional, Chen, Jing, additional, Liu, Xiaolong, additional, Dong, Liangqing, additional, Zhang, Yongjie, additional, Shen, Feng, additional, Cheng, Qingbao, additional, Sui, Chengjun, additional, Liu, Jingfeng, additional, Wang, Hongyang, additional, Xia, Qiang, additional, and Chen, Lei, additional

Published
2021
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9. Trajectory and Functional Analysis of PD‐1 high CD4 + CD8 + T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing

Author

Zheng, Bo, primary, Wang, Dongfang, additional, Qiu, Xinyao, additional, Luo, Guijuan, additional, Wu, Tong, additional, Yang, Shuai, additional, Li, Zhixuan, additional, Zhu, Yanjing, additional, Wang, Shan, additional, Wu, Rui, additional, Sui, Chengjun, additional, Gu, Ziqi, additional, Shen, Siyun, additional, Jeong, Seogsong, additional, Wu, Xuan, additional, Gu, Jin, additional, Wang, Hongyang, additional, and Chen, Lei, additional

Published
2020
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10. Latent Risk Intrahepatic Cholangiocarcinoma Susceptible to Adjuvant Treatment After Resection: A Clinical Deep Learning Approach

Author

Jeong, Seogsong, primary, Ge, Yang, additional, Chen, Jing, additional, Gao, Qiang, additional, Luo, Guijuan, additional, Zheng, Bo, additional, Sha, Meng, additional, Shen, Feng, additional, Cheng, Qingbao, additional, Sui, Chengjun, additional, Liu, Jingfeng, additional, Wang, Hongyang, additional, Xia, Qiang, additional, and Chen, Lei, additional

Published
2020
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11. Trajectory and Functional Analysis of PD‐1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing.

Author

Zheng, Bo, Wang, Dongfang, Qiu, Xinyao, Luo, Guijuan, Wu, Tong, Yang, Shuai, Li, Zhixuan, Zhu, Yanjing, Wang, Shan, Wu, Rui, Sui, Chengjun, Gu, Ziqi, Shen, Siyun, Jeong, Seogsong, Wu, Xuan, Gu, Jin, Wang, Hongyang, and Chen, Lei

Subjects
T cells, HEPATOCELLULAR carcinoma, CYTOMETRY, FUNCTIONAL analysis, PROGRAMMED cell death 1 receptors
Abstract

The spatial heterogeneity of immune microenvironment in hepatocellular carcinoma (HCC) remains elusive. Here, a single‐cell study involving 17 432 600 immune cells of 39 matched HCC (T), nontumor (N), and leading‐edge (L) specimens by mass cytometry is conducted. The tumor‐associated CD4/CD8 double‐positive T (DPT) cells are found enriched in L regions with synergetic expression of PD‐1/HLA‐DR/ICOS/CD45RO and exhibit a higher level of IFN‐γ, TNF‐α, and PD‐1 upon stimulation. The enrichment of DPT and PD‐1+DPT in L regions indicates favorable prognosis. These tumor‐associated DPT cells with similar phenotype are also verified in other tumors and HCC animal models. Single‐cell RNA‐seq further characterizes the molecular features of DPT cells and uncovers 11 clusters with different cytotoxicity, exhaustion, and activation scores. TCR‐based trajectory analysis reveals that tumor‐associated DPT clusters share separated ancestries with local CD4+ or CD8+SPT cells rather than CD3+PBMC cells. TCR clones with frequency above 10 are mainly found coexisting in DPT and CD8+SPT cells. Specifically, PD‐1highDPT cluster (TDPT_10) shares the same ancestry with exhausted CD8+SPT cluster (TCD8T_2) and shows higher expression similarity and closer pathological location to PD‐1+CD8+ than PD‐1+CD4+T cells. Together, this study systematically characterizes the unique distribution of PD‐1+DPTs in HCC and puts forward new insights for the function and origin of tumor‐associated DPT cells. [ABSTRACT FROM AUTHOR]

Published
2020
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13. Recurrently deregulated lncRNAs in hepatocellular carcinoma

Author

Yang, Yang, primary, Chen, Lei, additional, Gu, Jin, additional, Zhang, Hanshuo, additional, Yuan, Jiapei, additional, Lian, Qiuyu, additional, Lv, Guishuai, additional, Wang, Siqi, additional, Wu, Yang, additional, Yang, Yu-Cheng T., additional, Wang, Dongfang, additional, Liu, Yang, additional, Tang, Jing, additional, Luo, Guijuan, additional, Li, Yang, additional, Hu, Long, additional, Sun, Xinbao, additional, Wang, Dong, additional, Guo, Mingzhou, additional, Xi, Qiaoran, additional, Xi, Jianzhong, additional, Wang, Hongyang, additional, Zhang, Michael Q., additional, and Lu, Zhi John, additional

Published
2017
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14. Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic, and transcriptomic profiling in paired primary tumor and PVTT samples

Author

Yang, Yang, primary, Chen, Lei, additional, Gu, Jin, additional, Zhang, Hanshuo, additional, Yuan, Jiapei, additional, Lian, Qiuyu, additional, Lv, Guishuai, additional, Wang, Siqi, additional, Wu, Yang, additional, Yang, Yu-Cheng T., additional, Wang, Dongfang, additional, Liu, Yang, additional, Tang, Jing, additional, Luo, Guijuan, additional, Li, Yang, additional, Hu, Long, additional, Sun, Xinbao, additional, Wang, Dong, additional, Guo, Mingzhou, additional, Xi, Qiaoran, additional, Xi, Jianzhong, additional, Wang, Hongyang, additional, Zhang, Michael Q., additional, and Lu, Zhi John, additional

Published
2016
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