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Objective To review the experience of metabolic evaluation of urinary stones in Peking Union Medical College Hospital, and summarize the ‘PUMCH model’ of metabolic evaluation. Methods With descriptive evaluation method, this study reviewed and analyzed 534 metabolic evaluation cases in the urology department of Peking Union Medical College Hospital from Jan. 2016 to Dec. 2021. The distribution differences of stone patients in gender, medical history, stone shape, stone composition, renal function, systemic metabolism and 24-hour urine metabolism were observed. Results This study found that males were more than females in terms of gender differences in stone patients; The average course of stone disease was about 10 years, and the first symptom was mainly renal colic; Calcium oxalate was the most common stone component; Kidney stone was more than urethral stone; Hyperlipidemia was the most common in patients with stones; The low concentration of urinary citrate was the most significant. Conclusions As a new method of stone diagnosis and treatment, the ‘PUMCH model’ of metabolic evaluation can comprehensively evaluate the patients' stone incidence and systemic metabolic abnormalities, which has a strong guiding role in stone treatment and prevention.

Objective: To further understand factors that influence health-related quality of life (HRQOL) in patients with ulcerative colitis (UC), especially the role of perceived stress and coping modes in Chinese patients with UC., Methods: This study was a cross-sectional study. Patients with UC were recruited from July 2013 to September 2014 in Peking Union Medical College Hospital. HRQOL was measured using the inflammatory bowel disease questionnaire (IBDQ). Perceived stress was measured by Perceived Stress Scale (PSS). Coping strategy was evaluated using Medical Coping Modes Questionnaire (MCMQ). Demographic data, course of the disease, clinical disease activity, and disease phenotype according to Montreal classification were also collected. Univariate analyses were conducted to determine which variables were associated with HRQOL, and those were statistically significant were entered into a multivariate regression model., Results: We recruited 214 patients (response rate 92.2%), whose median age was 37.5 (29.0, 49.3) years old and median course of UC was 4 (2, 9) years. Through univariate analyses, better HRQOL was significantly associated with regular medical visits, lower number of previous relapses and hospitalizations, no steroid use, Montreal E1, lower Mayo scores, clinical remission, less perceived stress and less acceptance strategy use. However, multivariate analyses revealed that perceived stress (OR=1.112, 95% CI 1.058-1.169), acceptance (OR=0.310, 95% CI 0.141-0.685), number of hospitalizations (OR=2.924, 95% CI 1.328-6.437) and clinical activity (OR=5.058, 95% CI 2.312-11.066) were most strongly related to HRQOL., Conclusions: HRQOL of UC patients are not only associated with clinical activity of the disease, but also associated with coping strategy and perceived stress. Further research needs to focus on whether or not relieving stress and guiding patients to cope with ulcerative colitis would improve HRQOL.

Poly-N-isopropylacrylamide (PNIPAAm) is a new kind of intelligent material. It shows favorable thermo sensitivity because of the structure of hydrophilic acrylamino and hydrophobic isopropyl. PNIPAAm also shows good biocompatibility and non-toxicity. All the characters as above make it an ideal extra cellular matrix material for tissue engineering. This paper reviews its application in tissue engineering.