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1. Separated Pairs of Submodules in Hilbert $C^*$-modules

Author: Eskandari, R., Luo, W., Moslehian, M. S., Xu, Q., and Zhang, H.
Subjects: Mathematics - Operator Algebras, Mathematics - Functional Analysis, 46L08, 46C05, 47A05, 47A30
Abstract: We introduce the notion of the separated pair of closed submodules in the setting of Hilbert $C^*$-modules. We demonstrate that even in the case of Hilbert spaces this concept has several nice characterizations enriching the theory of separated pairs of subspaces in Hilbert spaces. Let $\mathscr H$ and $\mathscr K$ be orthogonally complemented closed submodules of a Hilbert $C^*$-module $\mathscr E$. We establish that $ (\mathscr H,\mathscr K)$ is a separated pair in $\mathscr{E}$ if and only if there are idempotents $\Pi_1$ and $\Pi_2$ such that $\Pi_1\Pi_2=\Pi_2\Pi_1=0$ and $\mathscr R(\Pi_1)=\mathscr H$ and $\mathscr R(\Pi_2)=\mathscr K$. We show that $\mathscr R(\Pi_1+\lambda\Pi_2)$ is closed for each $\lambda\in \mathbb{C}$ if and only if $\mathscr R(\Pi_1+\Pi_2)$ is closed. We use the localization of Hilbert $C^*$-modules to define the angle between closed submodules. We prove that if $(\mathscr H^\perp,\mathscr K^\perp)$ is concordant, then $(\mathscr H^{\perp\perp},\mathscr K^{\perp\perp})$ is a separated pair if the cosine of this angle is less than one. We also present some surprising examples to illustrate our results., Comment: 20 pages
Published: 2024

2. Quantum criticality at cryogenic melting of polar bubble lattices

Author: Luo, W., Akbarzadeh, A., Nahas, Y., Prokhorenko, S., and Bellaiche, L.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Computational Physics, Quantum Physics
Abstract: Quantum fluctuations (QFs) caused by zero-point phonon vibrations (ZPPVs) are known to prevent the occurrence of polar phases in bulk incipient ferroelectrics down to 0K1-3. On the other hand, little is known about the effects of QFs on the recently discovered topological patterns in ferroelectric nanostructures4-9. Here, by using an atomistic effective Hamiltonian within classical Monte Carlo (CMC) and path integral quantum Monte Carlo (PI-QMC)1,3,10,11, we unveil how QFs affect the topology of several dipolar phases in ultrathin Pb(Zr0.4Ti0.6)O3 (PZT) films. In particular, our PI-QMC simulations show that the ZPPVs do not suppress polar patterns but rather stabilize the labyrinth4, bimeron5 and bubble phases12,13 within a wider range of bias field magnitudes. Moreover, we reveal that quantum fluctuations induce a quantum critical point (QCP) separating a hexagonal bubble lattice from a liquid-like state characterized by spontaneous motion, creation and annihilation of polar bubbles at cryogenic temperatures. Finally, we show that the discovered quantum melting is associated with anomalous physical response, as, e.g., demonstrated by a negative longitudinal piezoelectric coefficient., Comment: Nature communication, accepted, 21 pages, 4 Figs
Published: 2023

3. Higher Cognitive Reserve Is Beneficial for Cognitive Performance Via Various Locus Coeruleus Functional Pathways in the Pre-Dementia Stage of Alzheimer’s Disease

Author: Gong, Liang, Chen, K., Zhang, H., Zhang, S., Luo, W., Zhou, W., Zhang, B., Xu, R., and Xi, Chunhua
Published: 2024
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4. Origins of limited non-basal plasticity in the {\mu}-phase at room temperature

Author: Luo, W., Gasper, C., Zhang, S., Sun, P. L., Ulumuddin, N., Petrova, A., Lysogorskiy, Y., Drautz, R., Xie, Z., and Korte-Kerzel, S.
Subjects: Condensed Matter - Materials Science
Abstract: We unveil a new non-basal slip mechanism in the {\mu}-phase at room temperature using nanomechanical testing, transmission electron microscopy and atomistic simulation. The (1-105) planar faults with a displacement vector of 0.07[-5502] can be formed by dislocation glide. They do not disrupt the Frank-Kasper packing and therefore enable the accommodation of plastic strain at low temperatures without requiring atomic diffusion. The intersections between the (1-105) planar faults and basal slip result in stress concentration and crack nucleation during loading.
Published: 2023

5. Nonlinear phonon Hall effects in ferroelectrics: its existence and non-volatile electrical control

Author: Luo, W., Ji, J. Y., Chen, P., Xu, Y., Zhang, L. F., Xiang, H. J., and Bellaiche, L.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Computational Physics, Quantum Physics
Abstract: Nonlinear Hall effects have been previously investigated in non-centrosymmetric systems for electronic systems. However, they only exist in metallic systems and are not compatible with ferroelectrics since these latter are insulators, hence limiting their applications. On the other hand, ferroelectrics naturally break inversion symmetry and can induce a non-zero Berry curvature. Here, we show that a non-volatile electric-field control of heat current can be realized in ferroelectrics through the nonlinear phonon Hall effects. More precisely, based on Boltzmann equation under the relaxation-time approximation, we derive the equation for nonlinear phonon Hall effects, and further show that the behaviors of nonlinear phonon (Boson) Hall effects are very different from nonlinear Hall effects for electrons (Fermion). Our work provides a route for electric-field control of thermal Hall current in ferroelectrics., Comment: 16 pages, 2 figures
Published: 2023
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6. Are the $a_{0}(1710)$ or $a_{0}(1817)$ resonances in the $D_{s}^{+} \rightarrow K_{S}^{0}K^{+}\pi^{0}$ decay?

Author: Wang, Zhong-Yu, Peng, Yu-Wen, Yi, Jing-Yu, Luo, W. C., and Xiao, C. W.
Subjects: High Energy Physics - Phenomenology
Abstract: The BESIII Collaboration claimed that a new $a_{0}(1817)$ resonance was found in the recent results of the $D_{s}^{+} \rightarrow K_{S}^{0}K^{+}\pi^{0}$ decay. For this decay process, we perform a unitary amplitude to analyze the contributions of the states $a_{0}(980)^{+}$ and $a_{0}(1710)^{+}$ with the final state interactions. Considering the Cabibbo-favored external and internal $W$-emission mechanisms at the quark level, and the contributions of the resonances $a_{0}(980)^{+}$, $a_{0}(1710)^{+}$ in the $S$-wave and $\bar{K}^{*}(892)^{0}$, ${K}^{*}(892)^{+}$ in the $P$-wave, the recent experimental data of the $K_{S}^{0}K^{+}$ invariant mass spectrum from the BESIII Collaboration can be described well. In our results, the states $a_{0}(980)$ and $a_{0}(1710)$ are dynamically generated from the final state interactions of $K\bar{K}$ and $K^{*}\bar{K}^{*}$, respectively, which support the molecular nature for them. Moreover, some obtained branching fractions are in agreement with the experimental measurements.
Published: 2023

7. Metagenomic Next-Generation Sequencing for Accurate Diagnosis of Pneumocystis jirovecii Pneumonia: A Comparative Study with Traditional Methods

Author: Luo W, Lin X, Chen Y, and Zhang H
Subjects: mngs, pneumocystis jirovecii pneumonia, pulmonary infections, dominant pathogens, sensitivity, Infectious and parasitic diseases, RC109-216
Abstract: Wentao Luo,1 Xiuwen Lin,1 Yuchong Chen,2 Wenfeng Luo,3 Huagen Zhang1 1The Third Department of Critical Care Medicine, Meizhou People’s Hospital, Meizhou, Guangdong, 514000, People’s Republic of China; 2The Fourth Department of Critical Care Medicine, Meizhou People’s Hospital, Meizhou, Guangdong, 514000 People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Meizhou People’s Hospital, Meizhou, Guangdong, 514000, People’s Republic of ChinaCorrespondence: Huagen Zhang, The Third Department of Critical Care Medicine, Meizhou People’s Hospital, Meizhou, Guangdong, 514000, People’s Republic of China, Tel +8613549175546, Email 672825592@qq.comBackground: Metagenomic next-generation sequencing (mNGS) is a high-throughput sequencing technique that identifies a wide array of pathogens directly from clinical specimens. This study evaluates the diagnostic value of mNGS in Pneumocystis jirovecii pneumonia (PJP) and compares its efficacy with traditional detection methods, including Grocott’s Methenamine Silver (GMS) staining, serum (1– 3)-β-D-Glucan (BDG) testing, and Lactate Dehydrogenase (LDH) testing.Methods: Seventy-eight patients hospitalized between January 2022 and March 2023 with suspected pulmonary infections were included. Patients were eligible for mNGS if they exhibited symptoms such as fever, cough, dyspnea, or progressive hypoxemia, and met specific clinical criteria for PJP. Specimens obtained included bronchoalveolar lavage fluid, sputum, and peripheral blood. Positive rates and pathogen distributions detected by mNGS and traditional methods were compared.Results: In the PJP group, 25%, 37.5%, and 9.38% of patients had solid organ tumors, corticosteroid use, and skin diseases, respectively, significantly higher than in the non-PJP group. The sensitivity and specificity of mNGS were both 100%, significantly higher than those of serum BDG (sensitivity 50%, specificity 81.8%) and LDH (sensitivity 9.3%, specificity 91.3%). Significant differences in microbial composition between the PJP and Non-PJP groups were observed. mNGS detected multiple mixed pathogens in 96.88% of PJP cases, with 68.75% exhibiting mixed bacterial and viral infections. Notably, 71% of patients improved following antibacterial treatment based on mNGS results.Conclusion: mNGS technology shows superior sensitivity and specificity in diagnosing PJP and guides precise treatment for complex pulmonary infections.Keywords: mNGS, Pneumocystis jirovecii pneumonia, pulmonary infections, dominant pathogens, sensitivity
Published: 2024

8. Comparison of the Clinical Outcomes Between Reperfusion and Non-Reperfusion Therapy in Elderly Patients with Acute Ischemic Stroke

Author: Luo X, Chen S, Luo W, Li Q, Zhu Y, and Li J
Subjects: acute ischemic stroke, elderly, intravenous thrombolysis, mechanical thrombectomy, symptomatic intracranial hemorrhage, therapeutic efficacy, Geriatrics, RC952-954.6
Abstract: Xuanwen Luo, Suqin Chen,&ast; Weiliang Luo,&ast; Qingyun Li, Yening Zhu, Jiming Li Department of Neurology, Huizhou Central People’s Hospital, Huizhou, Guangdong Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weiliang Luo; Suqin Chen, Department of Neurology, Huizhou Central People’s Hospital, No. 41, Eling North Road, Huizhou, Guangdong Province, 516001, People’s Republic of China, Tel +8613631986803, Fax +867522288160, Email lwl306@126.com; csq621@139.comPurpose: To investigate the benefit (90-day mRS score) and rate of major complications (early symptomatic intracranial hemorrhage-SICH) after reperfusion therapy (RT) (including intravenous thrombolysis -IVT and mechanical thrombectomy -MT) in patients over 80 years with acute ischemic stroke (AIS).Patients and Methods: AIS patients aged over 80 admitted to Huizhou Central People’s Hospital from September 2018 to 2023 were included in this study. Data on SICH, NIHSS, and mRS were analyzed. A good prognosis was defined as a mRS ≤ 2 or recovery to pre-stroke status at 90 days.Results: Of 209 patients, 80 received non-RT, 100 received IVT and 29 underwent MT. The non-RT group had the lowest baseline NIHSS while the MT group had the highest (non-RT 6.0 vs IVT 12.0 vs MT 18.0, P < 0.001). Higher NIHSS was associated with increased SICH risk (OR 1.083, P=0.032), while RT was not (OR 5.194, P=0.129). The overall SICH rate in the RT group was higher but not significantly different after stratification by stroke severity. Poor prognosis was associated with higher admission NIHSS, stroke due to large artery atherosclerosis (LAA) combined with cardioembolism (CE), and stroke-associated pneumonia (SAP) (OR 0.902, P< 0.001; OR 0.297, P=0.029; OR 0.103, P< 0.001, respectively). The RT group showed a greater reduction in NIHSS (delta NIHSS) than the non-RT group (non-RT 2.0 vs IVT 4.0 vs MT 6.0, P< 0.005). For severe AIS, the IVT group had a better prognosis at 90 days (non-RT 0% vs IVT 38.2%, P=0.039). No 90-day mortality difference was found between groups after stratification.Conclusion: Stroke severity, rather than RT, is an independent risk factor for SICH in AIS patients over 80. RT in severe stroke patients improves NIHSS at 90 days, suggesting RT is safe and effective in this demographic. Further studies with larger samples are required to confirm these findings.Keywords: acute ischemic stroke, elderly, intravenous thrombolysis, mechanical thrombectomy, symptomatic intracranial hemorrhage, therapeutic efficacy
Published: 2024

9. Impact of Combined Chemotherapy and Targeted Therapy on Pancreatic Neuroendocrine Carcinoma with Liver Metastasis: A Single-Center Modified Nomogram Analysis

Author: Luo W, Chen H, and Zhang T
Subjects: pancreatic neuroendocrine carcinoma, liver metastasis, nomogram model, targeted therapy, chemotherapy, overall survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Wenhao Luo, Hao Chen, Taiping Zhang Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of ChinaCorrespondence: Taiping Zhang, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China, Email zhangtaiping@pumch.cnObjective: To establish a modified nomogram model for pancreatic neuroendocrine carcinoma (pNEC) patients with liver metastasis via single-center clinical data, and to provide guidelines for improving the diagnosis and treatment of patients.Methods: A retrospective analysis of clinical data from pNEC patients with liver metastasis at Peking Union Medical College Hospital (January 2000 to November 2023) was conducted. Univariate and multivariate Cox regression analyses were employed to identify prognostic factors for overall survival (OS). Kaplan-Meier curves were generated, and a modified nomogram predictive model was developed to illustrate the prognosis of pNEC patients with liver metastasis. Calibration plots and C-index were used to validate the model’s feasibility, accuracy, and reliability.Results: Forty-five participants with the rare cancer type pNEC and liver metastasis were included in the study. Kaplan-Meier curves revealed that primary tumor resection (PTR), chemotherapy or targeted therapy, and tumor size equal to or less than 5cm significantly improved OS compared to those without PTR, chemotherapy or targeted therapy, and tumor size larger than 5cm. Multivariate Cox regression analysis identified PTR, a combination of chemotherapy and targeted therapy, and tumor size as independent prognostic factors for OS. The predictive nomogram model exhibited acceptable performance with a C-index of 0.744 (0.639– 0.805) through bootstrapping.Conclusion: Combining chemotherapy with targeted therapy enhances the survival of pNEC patients with liver metastasis. The modified nomogram model and predictive score table offer valuable references and insights for both clinicians and patients.Keywords: pancreatic neuroendocrine carcinoma, liver metastasis, nomogram model, targeted therapy, chemotherapy, overall survival
Published: 2024

10. Human Equilibrative Nucleoside Transporter 1: Novel Biomarker and Prognostic Indicator for Patients with Gemcitabine-Treated Pancreatic Cancer

Author: Xiao J, Zhao F, Luo W, Yang G, Wang Y, Qiu J, Liu Y, You L, Zheng L, and Zhang T
Subjects: pancreatic cancer, human equilibrative nucleoside transporter 1 (hent1), gemcitabine chemoresistance, prognostic indicator, survival improvement, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Jianchun Xiao,1,&ast; Fangyu Zhao,1,&ast; Wenhao Luo,1,&ast; Gang Yang,1 Yicheng Wang,1 Jiangdong Qiu,1 Yueze Liu,1 Lei You,1 Lianfang Zheng,2 Taiping Zhang1,3 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 3Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Taiping Zhang, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China, Email zhangtaiping@pumch.cnAim: This article aimed to find appropriate pancreatic cancer (PC) patients to treat with Gemcitabine with better survival outcomes by detecting hENT1 levels.Methods: We collected surgical pathological tissues from PC patients who received radical surgery in our hospital from September 2004 to December 2014. A total of 375 PC tissues and paired adjacent nontumor tissues were employed for the construction of 4 tissue microarrays (TMAs). The quality of the 4 TMAs was examined by HE staining. We performed immunohistochemistry analysis to evaluate hENT1 expression in the TMAs. Moreover, we detected hENT1 expression level and proved the role of hENT1 in cell proliferation, drug resistance, migration and invasion in vivo and vitro.Results: The results indicated that low hENT1 expression indicated a significantly poor outcome in PC patients, including shortened DFS (21.6± 2.8 months versus 36.9± 4.0 months, p< 0.001) and OS (33.6± 3.9 versus 39.6± 3.9, p=0.004). Meanwhile, patients in stage I/II of TNM stage had a longer OS (40.2± 3.4 versus 15.4± 1.7, p=0.002) and DFS (31.0± 3.1 versus 12.4± 1.9, p=0.016) than patients in stage III/IV. Patients in M0 stage had a longer OS (39.7± 3.4 versus 16.2± 1.9, p=0.026) and DFS(30.7± 3.0 versus 11.8± 2.2, p=0.031) than patients in M1 stage, and patients with tumors not invading the capsule had a better DFS than those with tumor invasion into the capsule (30.8± 3.0 versus 12.6± 2.3, p=0.053). Patients with preoperative CA19-9 values ≤ 467 U/mL have longer DFS than that of patients who had preoperative CA19-9 values > 467 U/mL (37.9± 4.1 versus 22.9± 4.0, p=0.04). In the subgroup analysis, a high hENT1 expression level was related to a longer OS(39.4± 4.0 versus 31.5± 3.9, p=0.001) and DFS(35.7± 4.0 versus 20.6± 2.7; p< 0.0001) in the Gemcitabine subgroup.Conclusion: PC patients with high hENT1 expression have a better survival outcomes when receiving Gemcitabine. hENT1 expression can be a great prognostic indicator for PC patients to receive Gemcitabine treatment.Keywords: pancreatic cancer, human equilibrative nucleoside transporter 1, hENT1, gemcitabine chemoresistance, prognostic indicator, survival improvement
Published: 2024

11. Metallurgical synthesis methods for Mg-Al-Ca scientific model materials

Author: Luo, W., Tanure, L., Felten, M., Nowak, J., Delis, W., Freund, M., Ayeb, N., Zander, D., Thomas, C., Feuerbacher, M., Sandlöbes-Haut, S., Korte-Kerzel, S., and Springer, H.
Subjects: Condensed Matter - Materials Science
Abstract: Mg-based alloys are industrially used for structural applications, both as solid solutions alloys and as composites containing intermetallic compounds. However, a further development in terms of mechanical properties requires the investigation of underlying causalities between synthesis, processing and microstructure to adjust the mechanical and the corrosion properties, ideally down to the near atomic scale. Such fundamental scientific investigations with high resolution characterisation techniques require model materials of exceptionally high purity and strictly controlled microstructure e.g. with respect to grain size, morphology, chemical homogeneity as well as content and size of oxide inclusions. In this context, the Mg-Al-Ca system appears exceptionally challenging from a metallurgical perspective due to the high reactivity and high vapor pressures, so that conventional industrial techniques cannot be successfully deployed. Here, we demonstrate the applicability of various scientific synthesis methods from arc melting over solution growth to diffusion couples, extending to effects and parameters for thermo-mechanical processing. Suitable pathways to overcome the specific challenges of the Mg-Al-Ca system are demonstrated, as well as the persistent limitations of the current state of the art laboratory metallurgy technology., Comment: 17 pages, 7 figures
Published: 2023

12. Fast Processing of Bending Deflection for Euler–Bernoulli Beam Under Different Boundary Constraints Based on a Semi-Analytical Null Space Method

Author: Luo, W. J., Liu, T. Y., Chai, T. J., Yan, J. W., and Guo, W. J.
Published: 2023
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13. Plasticity of the Nb-rich {\mu}-Co7Nb6 phase at room temperature and 600 {\deg}C

Author: Luo, W., Xie, Z., Sun, P. -L., Gibson, J. S. K. -L., and Korte-Kerzel, S.
Subjects: Condensed Matter - Materials Science
Abstract: The {\mu}-phase is a common precipitation phase in superalloys and it exists in a wide composition and temperature range. As such, we study the influences of composition and temperature on its plasticity by micropillar compression tests and transmission electron microscopy. The micropillars of the {\mu}-Co7Nb6 phase deform plastically by basal slip at either room temperature or 600 oC. At room temperature, the Co-49Nb and Co-52Nb micropillars show high yield stresses and an abrupt large strain burst at the onset of yielding regardless of orientation, whereas the Co-54Nb micropillars oriented for basal slip yield at much lower stresses and show intermittent small strain bursts during plastic deformation. While the Co-49Nb micropillars deform by full dislocation slip on the basal plane at room temperature, the Co-54Nb micropillars deform by partial dislocation slip on the basal plane. At 600 oC, the Co-49Nb micropillars oriented for basal slip show stable and continuous plasticity and their critical resolved shear stress decreases dramatically. The plastic deformation of the Co-49Nb micropillars occurs via partial dislocation slip on the basal plane at 600 oC. Based on the geometric {\gamma}-surfaces for all potential basal slip planes, we explore where and why the glide of full and partial dislocations on the basal plane occurs in the {\mu}-Co7Nb6 phase.
Published: 2023
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14. Study of charm and beauty mass spectra, semileptonic decays of $B_{(s,c)}$ and ${B_c} \to J/\psi ({\eta _c}) + P(V)$ in a phenomenological potential model

Author: Rahmani, S., Luo, W. C., and Xiao, C. W.
Subjects: High Energy Physics - Phenomenology
Abstract: Using a non-relativistic potential model, we obtain the mass spectra, leptonic decay constants, and parameters of the Isgur-Wise function for the beauty and charm mesons. With the calculated quantities, we investigate purely leptonic decays of $B^+$, $B^{*}$, $B_c^+$, semileptonic decay modes ${B_{(s)}} \to {D_{(s)}}l\nu $ and ${B_c} \to {\eta _c}\ell \bar \nu $ for three lepton channels $e,\mu ,\tau$, and obtain the corresponding branching fractions. $\bar B_{(s)}^{} \to D_{(s)}^*l\bar \nu $ transitions are also studied. Next, we apply the form factors for spin zero and spin one transitions of $B_c$ to calculate the nonleptonic branching ratios of ${B_c} \to J/\psi ({\eta _c}) + P(V)$, where $P$ and $V$ stand for the $D_q^{* - }$ vector meson and the $D_q$ pseudoscalar meson, respectively. Our results are found to be in agreement with those obtained in the experimental and theoretical results.
Published: 2022
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15. Study on Predicting Clinical Stage of Patients with Bronchial Asthma Based on CT Radiomics

Author: Chen X, Wang X, Huang S, Luo W, Luo Z, and Chen Z
Subjects: bronchial asthma, ba, radiomics, computed tomography, ct, Immunologic diseases. Allergy, RC581-607
Abstract: Xiaodong Chen,1,&ast; Xiangyuan Wang,1,&ast; Shangqing Huang,1 Wenxuan Luo,1 Zebin Luo,1,&ast; Zipan Chen2,&ast; 1Radiology Imaging Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang City, People’s Republic of China; 2Health Management Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang City, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zipan Chen; Zebin Luo, Email 41881014@qq.com; gdmcfsjd@qq.comObjective: To explore the value of a new model based on CT radiomics in predicting the staging of patients with bronchial asthma (BA).Methods: Patients with BA from 2018 to 2021 were retrospectively analyzed and underwent plain chest CT before treatment. According to the guidelines for the prevention and treatment of BA (2016 edition), they were divided into two groups: acute attack and non-acute attack. The images were processed as follows: using Lung Kit software for image standardization and segmentation, using AK software for image feature extraction, and using R language for data analysis and model construction (training set: test set = 7: 3). The efficacy and clinical effects of the constructed model were evaluated with ROC curve, sensitivity, specificity, calibration curve and decision curve.Results: A total of 112 patients with BA were enrolled, including 80 patients with acute attack (range: 2– 86 years old, mean: 53.89± 17.306 years old, males of 33) and 32 patients with non-acute attack (range: 4– 79 years old, mean: 57.38± 19.223 years old, males of 18). A total of 10 imaging features are finally retained and used to construct model using multi-factor logical regression method. In the training group, the AUC, sensitivity and specificity of the model was 0.881 (95% CI:0.808– 0.955), 0.804 and 0.818, separately; while in the test group, it was 0.792 (95% CI:0.608– 0.976), 0.792 and 0.80, respectively.Conclusion: The model constructed based on radiomics has a good effect on predicting the staging of patients with BA, which provides a new method for clinical diagnosis of staging in BA patients.Keywords: bronchial asthma, BA, Radiomics, computed tomography, CT
Published: 2024

16. Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin

Author: Liu W, Huang X, Luo W, Liu X, and Chen W
Subjects: progerin, paxillin, migration, proliferation, melanoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Weixian Liu,1,2 Xinxian Huang,1– 3 Weizhao Luo,1,2 Xinguang Liu,1,2 Weichun Chen1,2 1Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Dongguan, People’s Republic of China; 2Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, People’s Republic of China; 3School of Medical Technology, Guangdong Medical University, Dongguan, People’s Republic of ChinaCorrespondence: Xinguang Liu; Weichun Chen, Tel +86-13922926543 ; +86-13694959795, Email xgliu64@126.com; chenwchun@126.comObjective: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role of progerin in melanoma.Materials and Methods: We constructed the melanoma A375 cell line and M14 cell line with stable expression of progerin. The expression of progerin, paxillin, and epithelial-mesenchymal transition (EMT) marker proteins in each cell group was measured using Western blot. The migration, proliferation, and cell cycle of cancer cells were assessed using the transwell assay, wound healing assay, colony formation assay, CCK 8 assay, and flow cytometry. RT-qPCR technology was used to examine the impact of progerin overexpression on microRNA expression. Finally, we transfected paxillin into the progerin overexpression cell group to verify whether progerin regulates the phenotype of tumor cells through paxillin.Results: Our study demonstrated that overexpression of progerin leads to decreased expression of paxillin and inhibits cancer cell migration, proliferation, EMT process and cell cycle progression. Additionally, rescue experiments revealed that the migration, proliferation ability, and EMT marker protein expression in progerin overexpressing cancer cells could be partially restored by transfecting a plasmid containing the paxillin gene. Mechanistic investigations further revealed that progerin achieves this inhibition of paxillin expression by upregulating miR-212.Conclusion: This study reveals that progerin may inhibit the migration and proliferation of melanoma cells through the miR-212/paxillin axis, which provides a new approach for the future treatment of this disease.Keywords: progerin, paxillin, migration, proliferation, melanoma
Published: 2024

17. Ionic Crystals of Na{[TM(phen)3][Eu(dpa)3]}·17H2O (TM = Ni, Co): Single-Crystal Structure and Luminescence Properties

Author: Zhang, H. L., Shi, W. J., Le, N., Tang, C. Y., Chen, X. Z., Zhao, C., and Luo, W.
Published: 2023
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18. Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae: Risk Factors and Economic Burden Among Patients with Bloodstream Infections

Author: Chen J, Allel K, Zhuo C, Luo W, He N, Yang X, Guo Y, Wang J, Yao L, Li J, Lin Y, Tu R, and Yakob L
Subjects: escherichia coli, klebsiella pneumoniae, bacteremia, esbl, risk factors, medical costs, Public aspects of medicine, RA1-1270
Abstract: Jiakang Chen,1,&ast; Kasim Allel,2– 4,&ast; Chuyue Zhuo,1,&ast; Wenwei Luo,5 Nanhao He,1 Xu Yang,1 Yingyi Guo,1 Jiong Wang,1 Likang Yao,1 Jiahui Li,1 Yexin Lin,1 Ruiyang Tu,6 Laith Yakob,2,3 Chao Zhuo1 1State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Disease Control, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; 3Antimicrobial Resistance Centre, London School of Hygiene & Tropical Medicine, London, UK; 4Institute for Global Health, University College London, London, UK; 5Department of Clinical Laboratory, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 6Department of Science and Technology Studies, University College London, London, UK&ast;These authors contributed equally to this workCorrespondence: Chao Zhuo, State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, People’s Republic of China, Email chaosheep@gzhmu.edu.cnIntroduction: Although Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae (ESBL-EK) significantly contribute to bloodstream infections, their economic repercussions remain largely unquantified.Data Source and Methods: We performed a retrospective analysis of inpatients diagnosed with Escherichia coli or Klebsiella pneumoniae bacteremia in a tertiary hospital from January 2020 to December 2022 in Guangzhou, China. We employed the chi-square test to examine ESBL risk factors and utilized propensity score matching (PSM) to negate baseline confounding factors, assessing economic burden through disability-adjusted life years (DALYs), hospital costs and productivity losses. We employed mediation analysis to eliminate confounding factors and better identify ESBL sources of burden related.Results: We found 166 ESBL-EC/KP BSI patients (52.2% of the total examined 318 patients). Post-PSM analysis revealed that ESBL-producing EC/KP will reduce the effectiveness of empirical medication by 19.8%, extend the total length of hospitalization by an average of 3 days, and increase the patient’s financial burden by US&dollar;2047. No significant disparity was found in overall mortality and mean DALYs between the groups. Mediation analysis showed that the link between ESBL and hospital costs is predominantly, if not entirely, influenced by the appropriateness of empirical antibiotic treatment and length of hospital stay.Conclusion: Patients with BSI due to ESBL-producing ESBL-EK incur higher costs compared to those with non-ESBL-EK BSI. This cost disparity is rooted in varying rates of effective empirical antimicrobial therapy and differences in hospital stay durations. A nuanced approach, incorporating a thorough understanding of regional epidemiological trends and judicious antibiotic use, is crucial for mitigating the financial impact on patients.Keywords: Escherichia coli, Klebsiella pneumoniae, bacteremia, ESBL, risk factors, medical costs
Published: 2024

19. Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics

Author: Ren X, Lin F, Tang C, Liu Y, Liao G, Liang J, Luo W, Zhang L, and Chen W
Subjects: neuroprotection, cholest-4-ene-3, 6-dione, anti-ros, lipidomics, molecular docking, Therapeutics. Pharmacology, RM1-950
Abstract: Xiaoshuai Ren,1,&ast; Feng Lin,2,&ast; Chaogang Tang,2,&ast; Yao Liu,3 Guolei Liao,2 Jiabi Liang,3 Wenji Luo,3 Lei Zhang,2 Wenli Chen3 1Department of Clinical Laboratory, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, 519000, People’s Republic of China; 2Department of Cerebrovascular Disease, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, 519000, People’s Republic of China; 3Department of Pharmacy, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, 519000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenli Chen; Lei Zhang, Tel +15626471884 ; +13726209240, Email chenwenl@mail3.sysu.edu.cn; zhangl92@mail.sysu.edu.cnPurpose: Stroke is a leading cause of disability and death globally. However, there are few clinical drugs for stroke therapy. Novel and effective neuroprotectants are called on the way.Methods: In this study, 93 steroids from a constructed steroidal library were randomly numbered and blindly evaluated in an L-glutamate-induced HT-22 oxidative stress model. The neuroprotective effects of 5 candidates were further investigated in potassium deprivation-induced apoptosis of cerebellar granule neurons (CGNs), D-glutamate-induced excitotoxicity of CGNs, and cortical neuron (CN) models.Results: Interestingly, unblinding revealed that cholest-4-ene-3,6-dione (78), a cholesterol derivative, was first found to have comprehensive neuroprotective effects in all cell models. 78 administration also decreased the infarction volume and improved motor function in middle cerebral artery occlusion (MCAO) model rats. Additionally, 78 treatment decreased intercellular reactive oxygen species (ROS) and NO production in the HT-22 cell model. Finally, lipidomics and molecular docking results showed that 78 may exert its neuroprotective effects by increasing platelet-activating factor (PAF) analog 1-(9Z-pentadecenoyl)-glycero-3-phosphocholine production.Conclusion: This study indicates that 78, a novel neuroprotectant, is a promising therapeutic candidate with comprehensive neuroprotective effects for the treatment of ischemic stroke by decreasing ROS/reactive nitrogen species (RNS) levels and increasing 1-(9Z-pentadecenoyl)-glycero-3-phospho-choline production. Keywords: neuroprotection, cholest-4-ene-3,6-dione, anti-ROS, lipidomics, molecular docking
Published: 2023

20. Feasibility of studying astrophysically important charged-particle emission with the variable energy $\gamma$-ray system at the Extreme Light Infrastructure -- Nuclear Physics facility

Author: Lan, H. Y., Luo, W., Xu, Y., Balabanski, D. L., Guardo, G. L., La Cognata, M., Lattuada, D., Matei, C., Pizzone, R. G., Rauscher, T., and Zhou, J. L.
Subjects: Nuclear Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Nuclear Theory
Abstract: In the environment of a hot plasma, as achieved in stellar explosions, capture and photodisintegration reactions proceeding on excited states in the nucleus can considerably contribute to the astrophysical reaction rate. Such reaction rates including the excited-state contribution are obtained from theoretical calculations as the direct experimental determination of these astrophysical rates is currently unfeasible. In the present study, ($\gamma$,p) and ($\gamma$,$\alpha$) reactions in the mass and energy range relevant to the astrophysical $p$ process are considered and the feasibility of measuring them with the ELISSA detector system at the future Variable Energy $\gamma$-ray (VEGA) facility at ELI-NP is investigated. The simulation results reveal that, for the ($\gamma$,p) reaction on twelve targets of $^{29}$Si, $^{56}$Fe, $^{74}$Se, $^{84}$Sr, $^{91}$Zr, $^{96,98}$Ru, $^{102}$Pd, $^{106}$Cd, and $^{115, 117, 119}$Sn, and the ($\gamma$,$\alpha$) reaction on five targets of $^{50}$V, $^{87}$Sr, $^{123,125}$Te, and $^{149}$Sm, the yields of the reaction channels with the transitions to the excited states in the residual nucleus are relevant and even dominant. It is further found that for each considered reaction, the total yields of the charged-particle $X$ may be dominantly contributed from one, two or three ($\gamma$,$X_{i}$) channels within a specific, narrow energy range of the incident $\gamma$-beam. Furthermore, the energy spectra of the ($\gamma$,$X_{i}$) channels with $0\leq i\leq 10$ are simulated for each considered reaction, with the incident $\gamma$-beam energies in the respective energy range as derived before. It becomes evident that measurements of the photon-induced reactions with charged-particle emissions considered in this work are feasible with the VEGA+ELISSA system and will provide knowledge useful for nuclear astrophysics., Comment: 11 figures, 17 pages
Published: 2022
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21. Transmutation of MAs and LLFPs with a lead-cooled fast reactor

Author: Sun, X. Y., Han, L. H., Li, X. X., Hu, B. L., Luo, W., and Liu, L.
Published: 2023
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22. Nomogram based on MRI and clinical features to predict progression-free survival in patients with stage IIIC1r cervical squamous cell carcinoma: A two-center study

Author: Luo, W.-X., Ding, X.-M., Cheng, J.-M., Liu, X., and Zhou, H.-Y.
Published: 2024
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23. CYP2C19 &ast;2/&ast;2 Genotype is a Risk Factor for Multi-Site Arteriosclerosis: A Hospital-Based Cohort Study

Author: Xie J, Pan T, Luo W, Zhang S, Fang Y, and Xu Z
Subjects: cyp2c19, genotype, multi-site atherosclerosis, polyvascular disease, Medicine (General), R5-920
Abstract: Jieyao Xie, Tingjun Pan, Weiwen Luo, Songsheng Zhang, Yuquan Fang, Zhou Xu Intensive Care Unit, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Jieyao Xie, Intensive Care Unit, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, People’s Republic of China, Email X1275014370@163.comBackground: Vascular diseases such as atherosclerosis usually affect multiple organs. Genetic factors have a certain proportion in the risk factors of atherosclerosis. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with multi-site atherosclerosis.Methods: The study included 410 patients with single-site atherosclerosis and 529 patients with multi-site atherosclerosis. The relationship between CYP2C19 rs4244285 and rs4986893 polymorphisms and single-site atherosclerosis and multi-site atherosclerosis was analyzed.Results: The proportion of CYP2C19 rs4244285 A allele (35.9% vs 29.9%, P=0.007) and rs4986893 G allele (97.7% vs 94.8%, P=0.001) in multi-site atherosclerosis group was significantly higher than that in single-site atherosclerosis group. The distribution of CYP2C19 genotypes was significantly different between the two groups (P=0.002). The results of univariate logistic regression indicated that CYP2C19 &ast;1/&ast;3 genotype (&ast;1/&ast;3 vs &ast;1/&ast;1: odds ratio (OR) 0.456, 95% confidence interval (CI): 0.231– 0.902, P=0.024) may decrease risk of multi-site atherosclerosis, while &ast;2/&ast;2 genotype (&ast;2/&ast;2 vs &ast;1/&ast;1: OR 1.780, 95% CI: 1.100– 2.880, P=0.019) may increase risk of multi-site atherosclerosis. Multivariate logistic regression (adjusted for gender, age, smoking, drinking, hypertension, and diabetes) indicated that CYP2C19 &ast;1/&ast;3 genotype (&ast;1/&ast;3 vs &ast;1/&ast;1: OR 0.459, 95% CI: 0.231– 0.909, P=0.026) may be an independent protective factor for multi-site atherosclerosis, while &ast;2/&ast;2 genotype (&ast;2/&ast;2 vs &ast;1/&ast;1: OR 1.767, 95% CI: 1.091– 2.864, P=0.021) may be an independent risk factor for multi-site atherosclerosis.Conclusion: CYP2C19 &ast;1/&ast;3 genotype may be an independent protective factor for multi-site atherosclerosis, while &ast;2/&ast;2 genotype may be an independent risk factor for multi-site atherosclerosis.Keywords: CYP2C19, genotype, multi-site atherosclerosis, polyvascular disease
Published: 2023

24. Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

Author: Sheng Y, Zeng Y, Luo W, Zhang X, Wang H, and Jiao J
Subjects: acute-on-chronic liver failure, hepatitis b virus, prothrombin time-international normalized ratio to albumin ratio, prognosis, Medicine (General), R5-920
Abstract: Yunjian Sheng,1,&ast; Yu Zeng,1,&ast; Wenling Luo,1 Xuemei Zhang,1 Hang Wang,2 Jiahuan Jiao3 1Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Gastroenterology, Dazhou Hospital of Integrated Traditional and Western Medicine, Dazhou, Sichuan, People’s Republic of China; 3Department of Infectious Diseases, the People’s Hospital of Leshan, Leshan, Sichuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yunjian Sheng, Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan Province, People’s Republic of China, Email sheng200410@163.comBackground: Acute-on-chronic liver failure is a common clinical syndrome with high short-term mortality, and early assessment of its mortality risk is crucial, but the search for valid and accurate prognostic biomarkers is a challenging endeavor. The purpose of this study was to investigate the predictive value of the prothrombin time-international normalized ratio to albumin ratio (PTAR) for mortality in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and methods: A total of 354 patients with HBV-ACLF were included in the retrospective study. Patients were divided into survival and non-survival groups based on 90-day follow-up. Cox regression analysis was used to explore the relationship between PTAR and 90-day mortality in patients with HBV-ACLF. The area under the receiver operating characteristic curve was used to evaluate the effectiveness of PTAR in predicting mortality.Results: PTAR was significantly higher in non-survivors than in survivors. The results of multivariate analysis showed that PTAR was a valid independent predictor of mortality in patients with HBV-ACLF. Its predictive ability for mortality was similar to that of the Child-Turcotte-Pugh score, the end-stage liver disease model (MELD) score, and the MELD-sodium score.Conclusion: PTAR may be a simple and effective tool for predicting the prognosis of patients with HBV-ACLF.Keywords: acute-on-chronic liver failure, hepatitis B virus, prothrombin time-international normalized ratio to albumin ratio, prognosis
Published: 2023

25. Non-basal plasticity in the μ-phase at room temperature

Author: Luo, W., Gasper, C., Zhang, S., Sun, P.L., Ulumuddin, N., Petrova, A., Lysogorskiy, Y., Drautz, R., Xie, Z., and Korte-Kerzel, S.
Published: 2024
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26. Cross section measurements of 27Al(γ, x)24Na reactions as monitors for laser-driven bremsstrahlung γ-ray

Author: Wang, M.Z., Wu, D., Lan, H.Y., Zhang, J.Y., Liu, J.X., Lu, H.G., Lv, J.F., Wu, X.Z., Zhang, H., Cai, J., Ma, Q.Y., Xia, Y.H., Wang, Z.N., Yang, Z.Y., Xu, X.L., Geng, Y.X., Zhao, Y.Y., Wang, H.R., Liu, F.L., Yu, J.Q., Luo, K.J., Luo, W., and Yan, X.Q.
Published: 2024
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27. The Mechanisms of Resistin-Like Molecule-β-Mediated Airway Inflammation in Chronic Obstructive Pulmonary Disease via Autophagy

Author: Che L, Xie Z, Chen G, Zhang W, Xia T, Lin J, Luo W, Chen L, Yin W, Cai X, and Liu S
Subjects: autophagy, copd, airway inflammation, cigarette smoke extract., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Li Che,1,2 Zhefan Xie,2,3 Guangshu Chen,4 Wei Zhang,2 Tingting Xia,2,3 Jiaxin Lin,2 Wenzhi Luo,2 Li Chen,2 Wenguang Yin,1 Xingdong Cai,2 Shengming Liu2 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 3Affiliated Dongguan People’s Hospital, Southern Medical University, Donguan, People’s Republic of China; 4Department of Endocrinology, Guangzhou Red Cross Hospital, The Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Shengming Liu; Xingdong Cai, The First Affiliated Hospital of Jinan University, Guangdong, People’s Republic of China, Email tlsm@jnu.edu.cn; cxd19790920@sina.comBackground: The role of irreversible airway inflammatory damage in chronic obstructive pulmonary disease (COPD) progression is evident. Autophagy is an essential process in the cellular material metabolic cycle, and a family of resistant vegetative molecules may be involved in the COPD autophagic process. In this study, we investigated the mechanism of resistin-like molecule β (RELMβ) in COPD smoking-induced autophagy.Methods: Firstly, the expression differences of RELMβ and autophagy markers between COPD and control groups were analyzed in the Gene Expression Omnibus (GEO) datasets and clinical specimens. Secondly, in vitro and in vivo experiments were conducted using immunoblotting, immunofluorescence, immunohistochemistry, and other methods to investigate the mechanism by which RELMβ promotes airway inflammation through autophagy in a cigarette smoke extract-induced 16HBE cell inflammation model and a cigarette smoke-induced COPD-like mouse model. In addition, immunoprecipitation was used to analyze the binding of RELMβ to the membrane protein TLR4.Results: The expression of RELMβ and autophagy genes p62 and LC3B in lung tissue of COPD patients was significantly increased. RELMβ can mediate the activation of autophagy in 16HBE cells, and through autophagy, it increases the expression of inflammatory cytokines in a cigarette smoke extract-induced 16HBE cell inflammation model. RELMβ promotes cigarette smoke-induced COPD-like mouse airway inflammation through autophagy, and RELMβ can mediate signal transduction through the cell membrane receptor TLR4.Conclusion: The RELMβ binds to TLR4 to encourage signal transduction and that RELMβ can promote inflammation in smoky COPD lungs through autophagy.Keywords: autophagy, COPD, airway inflammation, cigarette smoke extract
Published: 2023

28. Appropriateness of Empirical Antibiotic Therapy in Hospitalized Patients with Bacterial Infection: A Retrospective Cohort Study

Author: Luo Y, Guo Z, Li Y, Ouyang H, Huang S, Chen Y, Li K, Ji Y, Zhu H, Luo W, Liu X, Li X, and Xia J
Subjects: antimicrobial resistance, bacterial culture-positive, empirical antibiotic therapy, patient outcome, multidrug-resistant organism, Infectious and parasitic diseases, RC109-216
Abstract: Yuting Luo,1,&ast; Zhaowang Guo,2,&ast; Ying Li,1,&ast; Hui Ouyang,1 Shanfeng Huang,1 Yuanli Chen,3 Kenan Li,1 Yuxin Ji,1 Hongqiong Zhu,1 Wentao Luo,1 Xu Liu,1,4 Xinghua Li,1 Jinyu Xia,1 Xi Liu1 1Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, People’s Republic of China; 2Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, People’s Republic of China; 3Department of Hospital Infection Control, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, People’s Republic of China; 4Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xi Liu; Xinghua Li, Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 Meihua East Road, Xiangzhou District, Zhuhai, 519000, People’s Republic of China, Tel/Fax +86-756-252-8592, Email liuxi26@mail.sysu.edu.cn; lixh79@mail.sysu.edu.cnObjective: The incidence of inappropriate and excessive empirical antibiotic therapy is unclear. The aim of this study was to determine the prevalence of different empirical antibiotic therapy prescriptions, related factors, and outcomes in hospitalized patients with bacterial infection.Methods: A retrospective cohort study was performed and patients with bacterial infection who were admitted between October 1, 2019, and September 30, 2020, were included. Multivariable analysis was performed by the logistic regression model.Results: A total of 536 (42.6%) of the 1257 included patients received inappropriate empirical antibiotic therapy (IEAT), and 368 (29.3%) patients received appropriate but unnecessarily broad-spectrum empirical antibiotic therapy (AUEAT). MDRO (adjusted OR 2.932 [95% CI 2.201~3.905]; p < 0.001) and fever on admission (adjusted OR 0.592 [95% CI 0.415~0.844]; p = 0.004) were correlates of IEAT; sepsis (adjusted OR 2.342 [95% CI 1.371~3.999]; p = 0.002), age (adjusted OR 1.019 [95% CI 1.008~1.030]; p < 0.001), MDRO (adjusted OR 0.664 [95% CI 0.469~0.941]; p = 0.021), and urinary tract infection (adjusted OR 0.352 [95% CI 0.203~0.611]; p < 0.001) were correlates of AUEAT. Patients who received AUEAT were more likely to have a poor prognosis (63 [17.8%] vs 101 [27.4%]; p = 0.002). Both IEAT (median [IQR], 24,971 [13,135– 70,155] vs 31,489 [14,894– 101,082] CNY; p = 0.007) and AUEAT (median [IQR], 24,971 [13,135– 70,155] vs 30,960 [16,475– 90,881] CNY; p = 0.002) increased hospital costs. 45.3% (570/1257) of patients were infected with MDRO and 62.9% of them received IEAT.Conclusion: Inappropriate and excessive empirical antibiotic use was widely prevalent among hospitalized patients. Either inappropriate or excessive use of antibiotics may increase the burden of healthcare costs, the latter of which may be associated with poor prognosis. Clinicians need to be more judicious in choosing antibiotic(s). The MDRO epidemic was severe, especially in patients who received IEAT. It is imperative to take effective measures to improve the current situation of antibiotic abuse and antimicrobial resistance.Keywords: antimicrobial resistance, bacterial culture-positive, empirical antibiotic therapy, patient outcome, multidrug-resistant organism
Published: 2023

29. Spectroscopy of $A=9$ hyperlithium by the $(e,e^{\prime}K^{+})$ reaction

Author: Gogami, T., Chen, C., Kawama, D., Achenbach, P., Ahmidouch, A., Albayrak, I., Androic, D., Asaturyan, A., Asaturyan, R., Ates, O., Baturin, P., Badui, R., Boeglin, W., Bono, J., Brash, E., Carter, P., Chiba, A., Christy, E., Danagoulian, S., De Leo, R., Doi, D., Elaasar, M., Ent, R., Fujii, Y., Fujita, M., Furic, M., Gabrielyan, M., Gan, L., Garibaldi, F., Gaskell, D., Gasparian, A., Han, Y., Hashimoto, O., Horn, T., Hu, B., Hungerford, Ed. V., Jones, M., Kanda, H., Kaneta, M., Kato, S., Kawai, M., Khanal, H., Kohl, M., Liyanage, A., Luo, W., Maeda, K., Margaryan, A., Markowitz, P., Maruta, T., Matsumura, A., Maxwell, V., Meekins, D., Mkrtchyan, A., Mkrtchyan, H., Nagao, S., Nakamura, S. N., Narayan, A., Neville, C., Niculescu, G., Niculescu, M. I., Nunez, A., Nuruzzaman, Okayasu, Y., Petkovic, T., Pochodzalla, J., Qiu, X., Reinhold, J., Rodriguez, V. M., Samanta, C., Sawatzky, B., Seva, T., Shichijo, A., Tadevosyan, V., Tang, L., Taniya, N., Tsukada, K., Veilleux, M., Vulcan, W., Wesselmann, F. R., Wood, S. A., Yamamoto, T., Ya, L., Ye, Z., Yokota, K., Yuan, L., Zhamkochyan, S., and Zhu, L.
Subjects: Nuclear Experiment
Abstract: Missing mass spectroscopy with the $(e,e^{\prime}K^{+})$ reaction was performed at Jefferson Laboratory's Hall C for the neutron rich $\Lambda$ hypernucleus $^{9}_{\Lambda}{\rm Li}$. The ground state energy was obtained to be $B_{\Lambda}^{\rm g.s.}=8.84\pm0.17^{\rm stat.}\pm0.15^{\rm sys.}~{\rm MeV}$ by using shell model calculations of a cross section ratio and an energy separation of the spin doublet states ($3/2^{+}_1$ and $5/2^{+}_1$). In addition, peaks that are considered to be states of [$^{8}{\rm Li}(3^{+})\otimes s_{\Lambda}=3/2^{+}_{2}, 1/2^{+}$] and [$^{8}{\rm Li}(1^{+})\otimes s_{\Lambda}=5/2^{+}_{2}, 7/2^{+}$] were observed at $E_{\Lambda}({\rm no.~2})=1.74\pm0.27^{\rm stat.}\pm0.11^{\rm sys.}~{\rm MeV}$ and $E_{\Lambda}({\rm no.~3})=3.30\pm0.24^{\rm stat.}\pm0.11^{\rm sys.}~{\rm MeV}$, respectively. The $E_{\Lambda}({\rm no.~3})$ is larger than shell model predictions by a few hundred keV, and the difference would indicate that a ${\rm ^{5}He}+t$ structure is more developed for the $3^{+}$ state than those for the $2^{+}$ and $1^{+}$ states in a core nucleus $^{8}{\rm Li}$ as a cluster model calculation suggests., Comment: 5 pages, 3 figures
Published: 2021
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30. Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations

Author: Luo W, Tang S, Xiao X, Luo S, Yang Z, and Huang W
Subjects: modeling, advanced diabetic kidney disease, diabetic complications, hypertension, atherosclerosis, non-proteinuric diabetic kidney disease, Specialties of internal medicine, RC581-951
Abstract: Wenting Luo,1 Shiyun Tang,2 Xiang Xiao,1 Simin Luo,1 Zixuan Yang,1 Wei Huang,3 Songqi Tang1 1School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 3School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of ChinaCorrespondence: Wei Huang, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611137, People’s Republic of China, Email gracehw@126.com Songqi Tang, School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan Province, 571199, People’s Republic of China, Tel +86 18689713500, Email tangsongqi@hainmc.edu.cnAbstract: Animal models play a crucial role in studying the pathogenesis of diseases, developing new drugs, identifying disease risk markers, and improving means of prevention and treatment. However, modeling diabetic kidney disease (DKD) has posed a challenge for scientists. Although numerous models have been successfully developed, none of them can encompass all the key characteristics of human DKD. It is essential to choose the appropriate model according to the research needs, as different models develop different phenotypes and have their limitations. This paper provides a comprehensive overview of biochemical and histological phenotypes, modeling mechanisms, advantages and limitations of DKD animal models, in order to update relevant model information and provide insights and references for generating or selecting the appropriate animal models to fit different experimental needs.Keywords: modeling, advanced diabetic kidney disease, diabetic complications, hypertension, atherosclerosis, non-proteinuric diabetic kidney disease
Published: 2023

31. ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Author: Zhang S, Luo W, Pan T, Xie J, Xu Z, and Fang Y
Subjects: aldh2, polymorphism, hemorrhagic stroke, hakka, Medicine (General), R5-920
Abstract: Songsheng Zhang,1,2 Weiwen Luo,1,2 Tingjun Pan,1,2 Jieyao Xie,1,2 Zhou Xu,1,2 Yuquan Fang1,2 1Intensive Care Unit, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Songsheng Zhang, Intensive Care Unit, Meizhou People’s Hospital, No. 63 Huangtang Road, Meizhou, Guangdong Province, People’s Republic of China, Email Zsongsheng@163.comBackground: Hypertension is the main risk factor for hemorrhagic stroke. Aldehyde dehydrogenase 2 (ALDH2) may inhibit the occurrence of hypertension by anti-oxidative stress and vascular dilation. The purpose was to investigate the relationship of ALDH2 polymorphisms with hemorrhagic stroke in Hakka Chinese.Methods: A total of 329 patients with hemorrhagic stroke and 515 controls were enrolled, and medical records (smoking and drinking history, hypertension, and diabetes) were collected. The genotypes of ALDH2 rs671 of the two groups were detected and analyzed.Results: The proportion of the ALDH2 rs671 G/G, G/A, and A/A genotype in patients with hemorrhagic stroke was 55.9%, 37.4%, and 6.7%, respectively, while those were 65.0%, 30.7%, and 4.3% in controls, respectively. There was statistically significant difference in ALDH2 rs671 genotypes distribution (P=0.021) and alleles distribution (P=0.005) between patients and controls. Among hemorrhagic stroke patients, no statistically significant differences were observed between patients with ALDH2 different genotypes. Logistic regression analysis showed that there was significantly high risk of hemorrhagic stroke in men (male vs female: adjusted OR 1.711, 95% CI 1.154– 2.538, P=0.008), the presence of hypertension (with vs without hypertension: adjusted OR 16.095, 95% CI 10.958– 23.641, P< 0.001), and the presence of ALDH2 rs671 G/A genotype (G/A vs G/G: adjusted OR 1.679, 95% CI 1.151– 2.450, P=0.007) or A/A genotype (A/A vs G/G: adjusted OR 2.516, 95% CI 1.132– 5.591, P=0.024).Conclusion: ALDH2 rs671 polymorphism likely a risk factor for hemorrhagic stroke.Keywords: ALDH2, polymorphism, hemorrhagic stroke, Hakka
Published: 2023

32. Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector

Author: Bay, Daya, collaborations, JUNO, Abusleme, A., Adam, T., Ahmad, S., Aiello, S., Akram, M., Ali, N., An, F. P., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de André, J. P. A. M., Babic, A., Balantekin, A. B., Baldini, W., Baldoncini, M., Band, H. R., Barresi, A., Baussan, E., Bellato, M., Bernieri, E., Biare, D., Birkenfeld, T., Bishai, M., Blin, S., Blum, D., Blyth, S., Bordereau, C., Brigatti, A., Brugnera, R., Budano, A., Burgbacher, P., Buscemi, M., Bussino, S., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Cao, G. F., Cao, J., Caruso, R., Cerna, C., Chakaberia, I., Chang, J. F., Chang, Y., Chen, H. S., Chen, P. A., Chen, P. P., Chen, S. M., Chen, S. J., Chen, X. R., Chen, Y. W., Chen, Y. X., Chen, Y., Chen, Z., Cheng, J., Cheng, Y. P., Cheng, Z. K., Chepurnov, A., Cherwinka, J. J., Chiarello, F., Chiesa, D., Chimenti, P., Chu, M. C., Chukanov, A., Chuvashova, A., Clementi, ., Clerbaux, B., Di Lorenzo, S. Conforti, Corti, D., Costa, S., Corso, F. D., Cummings, J. P., Dalager, O., De La Taille, C., Deng, F. S., Deng, J. W., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Ding, Y. Y., Dirgantara, B., Dmitrievsky, S., Diwan, M. V., Dohnal, T., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dove, J., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Dwyer, D. A., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Fiorentini, G., Ford, R., Formozov, A., Fournier, A., Franke, S., Gallo, J. P., Gan, H. N., Gao, F., Garfagnini, A., Göttel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G. H., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, M., Gromov, V., Gu, M. H., Gu, W. Q., Gu, X. F., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, J. Y., Guo, L., Guo, W. L., Guo, X. H., Guo, Y. H., Guo, Z., Haacke, M., Hackenburg, R. W., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hans, S., He, M., He, W., Heeger, K. M., Heinz, T., Heng, Y. K., Herrera, R., Higuera, A., Hong, D. J., Hor, Y. K., Hou, S. J., Hsiung, Y. B., Hu, B. Z., Hu, H., Hu, J. R., Hu, J., Hu, S. Y., Hu, T., Hu, Z. J., Huang, C. H., Huang, G. H., Huang, H. X., Huang, Q. H., Huang, W. H., Huang, X. T., Huang, Y. B., Huber, P., Hui, J. Q., Huo, L., Huo, W. J., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Ioannisyan, D., Isocrate, R., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Johnson, R. A., Jollet, C., Jones, D., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Kettell, S. H., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Kohn, S., Korablev, D., Kouzakov, K., Kramer, M., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachacinski, B., Lachenmaier, T., Langford, T. J., Lee, J., Lee, J. H. C., Lefevre, F., Lei, L., Lei, R., Leitner, R., Leung, J., Li, C., Li, D. M., Li, F., Li, H. T., Li, H. L., Li, J., Li, J. J., Li, J. Q., Li, K. J., Li, M. Z., Li, N., Li, Q. J., Li, R. H., Li, S. C., Li, S. F., Li, S. J., Li, T., Li, W. D., Li, W. G., Li, X. M., Li, X. N., Li, X. L., Li, X. Q., Li, Y., Li, Y. F., Li, Z. B., Li, Z. Y., Liang, H., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, C. J., Lin, G. L., Lin, S. X., Lin, T., Lin, Y. H., Ling, J. J., Link, J. M., Lippi, I., Littenberg, L., Littlejohn, B. R., Liu, F., Liu, H., Liu, H. B., Liu, H. D., Liu, H. J., Liu, H. T., Liu, J. C., Liu, J. L., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, Y., Lokhov, A., Lombardi, P., Loo, K., Lorenz, S., Lu, C., Lu, H. Q., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luk, K. B., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mantovani, F., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Marshall, C., Martellini, C., Martin-Chassard, G., Caicedo, D. A. Martinez, Martini, A., Martino, J., Mayilyan, D., McDonald, K. T., McKeown, R. D., Müller, A., Meng, G., Meng, Y., Meregaglia, A., Meroni, E., Meyhöfer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muralidharan, P., Napolitano, J., Nastasi, M., Naumov, D. V., Naumova, E., Nemchenok, I., Nikolaev, A., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H. R., Paoloni, A., Park, J., Parkalian, N., Parmeggiano, S., Patton, S., Payupol, T., Pec, V., Pedretti, D., Pei, Y. T., Pelliccia, N., Peng, A. G., Peng, H. P., Peng, J. C., Perrot, F., Petitjean, P. A., Rico, L. F. Pineres, Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, S., Qian, X., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Raper, N., Re, A., Rebber, H., Rebii, A., Ren, B., Ren, J., Reveco, C. M., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Rohwer, L., Romani, A., Rosero, R., Roskovec, B., Roth, C., Ruan, X. C., Ruan, X. D., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shahzad, M., Shi, G., Shi, J. Y., Shi, Y. J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steiner, H., Steinmann, J., Stender, M., Strati, V., Studenikin, A., Sun, G. X., Sun, L. T., Sun, J. L., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Tmej, T., Treskov, K., Troni, G., Trzaska, W., Tse, W. -H., Tull, C. E., Tuve, C., van Waasen, S., Boom, J. Vanden, Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Viren, B., Volpe, C., Vorobel, V., Votano, L., Walker, P., Wang, C., Wang, C. H., Wang, E., Wang, G. L., Wang, J., Wang, K. Y., Wang, L., Wang, M. F., Wang, M., Wang, N. Y., Wang, R. G., Wang, S. G., Wang, W., Wang, W. S., Wang, X., Wang, X. Y., Wang, Y., Wang, Y. F., Wang, Y. G., Wang, Y. M., Wang, Y. Q., Wang, Z., Wang, Z. M., Wang, Z. Y., Watcharangkool, A., Wei, H. Y., Wei, L. H., Wei, W., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Wiebusch, C., Wong, S. C. F., Wong, H. L. H., Wonsak, B., Worcester, E., Wu, C. H., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xia, D. M., Xie, Y. G., Xie, Z. Q., Xing, Z. Z., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J. L., Xu, J., Xu, M. H., Xu, T., Xu, Y., Xue, T., Yan, B. J., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, C. G., Yang, H., Yang, J., Yang, L., Yang, X. Y., Yang, Y. F., Yang, Y. Z., Yao, H. F., Yasin, Z., Ye, J. X., Ye, M., Yegin, U., Yeh, M., Yermia, F., Yi, P. H., You, Z. Y., Young, B. L., Yu, B. X., Yu, C. X., Yu, C. Y., Yu, H. Z., Yu, M., Yu, X. H., Yu, Z. Y., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Yue, B. B., Zafar, N., Zambanini, A., Zeng, P., Zeng, S., Zeng, T. X., Zeng, Y. D., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, G. Q., Zhang, H. H., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, J. W., Zhang, P., Zhang, Q. M., Zhang, T., Zhang, X. M., Zhang, X. T., Zhang, Y., Zhang, Y. H., Zhang, Y. M., Zhang, Y. P., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, F. Y., Zhao, J., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, L., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, H. L., Zong, L., and Zou, J. H.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detector size difference between Daya Bay and JUNO, the Daya Bay data were used to tune the parameters of a newly developed optical model. Then, the model and tuned parameters were used in the JUNO simulation. This enabled to determine the optimal composition for the JUNO LS: purified solvent LAB with 2.5 g/L PPO, and 1 to 4 mg/L bis-MSB., Comment: 13 pages, 8 figures
Published: 2020

33. Study of charm and beauty mass spectra, semileptonic decays of B(s,c)Bc→J/ψ(ηc)+P(V) and B(s,c)Bc→J/ψ(ηc)+P(V) in a phenomenological potential model

Author: Rahmani, S., Luo, W. C., and Xiao, C. W.
Published: 2023
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34. Mechanisms causing injectivity decline and enhancement in geothermal projects

Author: Luo, W., Kottsova, A., Vardon, P.J., Dieudonné, A.C., and Brehme, M.
Published: 2023
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35. A review for nickel oxide hole transport layer and its application in halide perovskite solar cells

Author: Cai, X., Hu, T., Hou, H., Zhu, P., Liu, R., Peng, J., Luo, W., and Yu, H.
Published: 2023
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36. Up-Regulation of ProBDNF/p75NTR Signaling in Spinal Cord Drives Inflammatory Pain in Male Rats

Author: Li H, Liu T, Sun J, Zhao S, Wang X, Luo W, Luo R, Shen W, Luo C, and Fu D
Subjects: brain-derived neurotrophic factor precursor, inflammatory pain, spinal cord, neuron, pan neurotrophin receptor 75, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Hui Li,1,2,&ast; Tao Liu,1,2,&ast; Jingjing Sun,1,2 Shuai Zhao,1,2 Xin Wang,1,2 Wei Luo,1,2 Ruyi Luo,1,2 Weiyun Shen,1,2 Cong Luo,1,2 Di Fu3 1Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Hunan Province Center for Clinical Anesthesia and Anesthesiology, Research Institute of Central South University, Changsha, People’s Republic of China; 3Department of Anesthesiology, the XiangYa Hospital, Central South University, ChangSha, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Di Fu, Department of Anesthesiology, the XiangYa Hospital, Central South University, Xiangya Road No. 86, Changsha, Hunan Province, 410011, People’s Republic of China, Tel/Fax +86 85295987, Email xyyyfudi@csu.edu.cnBackground: The spinal cord expresses brain-derived neurotrophic factor precursor (proBDNF) and its receptor pan neurotrophin receptor 75 (p75NTR). However, the role of spinal proBDNF signaling in the pathogenesis of inflammatory pain remains unknown.Methods: Rats were locally injected with complete Freund’s adjuvant (CFA) to induce inflammatory pain. The proBDNF signal expression was detected by double-labeled immunofluorescence. ProBDNF protein, p75NTR extracellular domain (p75NTR-ECD), or monoclonal anti-proBDNF (McAb-proB) were administrated by intrathecal injection to investigate their effects on pain behavior. Paw withdrawal thermal latency (PWL) and paw withdrawal mechanical threshold (PWT) were performed to evaluate pain behavior. Immunoblotting, immunohistochemistry, and immunofluorescence were used to assess inflammation-induced biochemical changes.Results: CFA induced a rapid increase in proBDNF in the ipsilateral spinal cord, and immunofluorescence revealed that CFA-enhanced proBDNF was expressed in NeuN positive neurons and GFAP positive astrocytes. The administration of furin cleavage-resistant proBDNF via intrathecal injection (I.t.) significantly decreased the PWT and PWL, whereas McAb-proB by I.t. alleviated CFA-induced pain-like hypersensitivity in rats. Meanwhile, CFA administration triggered the activation of p75NTR and its downstream signaling extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor (NF)-kappaB p65 in the spinal cord. I.t. administration of p75NTR-ECD suppressed CFA-induced pain and neuroinflammation, including the expression of p-ERK1/2, p-p65, and the gene expression of tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6).Conclusion: Our study reveals that the activated proBDNF/p75NTRsignaling in the spinal cord contributes to the development of CFA-induced inflammatory pain. McAb-proB and p75NTR-ECD appear to be promising therapeutic agents for inflammatory pain.Keywords: brain-derived neurotrophic factor precursor, inflammatory pain, spinal cord, neuron, pan neurotrophin receptor 75
Published: 2023

37. Fabrication and Microstructure of 30-Filament Jelly-Roll Nb3Al Superconducting Wires with Very High Critical Current Density

Author: Luo, W. Y., Zhou, E. F., Jin, H., Lin, H., and Pan, X. F.
Published: 2022
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38. Measurement of the single-spin asymmetry $A_y^0$ in quasi-elastic $^3$He$^\uparrow$($e,e'n$) scattering at $0.4 < Q^2 < 1.0$ GeV$/c^2$

Author: Long, E., Zhang, Y. W., Mihoviloviv, M., Jin, G., Sulkosky, V., Kelleher, A., Anderson, B., Higinbotham, D. W., Sirca, S., Allada, K., Annand, J. R. M., Averett, T., Bertozzi, W., Boeglin, W., Bradshaw, P., Camsonne, A., Canan, M., Cates, G. D., Chen, C., Chen, J. -P., Chudakov, E., De Leo, R., Deng, X., Deur, A., Dutta, C., Fassi, L. El, Flay, D., Frullani, S., Garibaldi, F., Gao, H., Gilad, S., Gilman, R., Glamazdin, O., Golge, S., Gomez, J., Hansen, J. -O., Holmstrom, T., Huang, J., Ibrahim, H., de Jager, C. W., Jensen, E., Jiang, X., Jones, M., Kang, H., Katich, J., Khanal, H. P., King, P. M., Korsch, W., LeRose, J., Lindgren, R., Lu, H. -J., Luo, W., Markowitz, P., Meziane, M., Michaels, R., Moffit, B., Monaghan, P., Muangma, N., Nanda, S., Norum, B. E., Pan, K., Parno, D., Piasetzky, E., Posik, M., Punjabi, V., Puckett, A. J. R., Qian, X., Qiang, Y., Qui, X., Riordan, S., Saha, A., Sawatzky, B., Shabestari, M., Shahinyan, A., Shoenrock, B., John, J. St., Subedi, R., Tobias, W. A., Tireman, W., Urciuoli, G. M., Wang, D., Wang, K., Wang, Y., Watson, J., Wojtsekhowski, B., Ye, Z., Zhan, X., Zhang, Y., Zheng, X., Zhao, B., and Zhu, L.
Subjects: Nuclear Experiment
Abstract: Due to the lack of free neutron targets, studies of the structure of the neutron are typically made by scattering electrons from either $^2$H or $^3$He targets. In order to extract useful neutron information from a $^3$He target, one must understand how the neutron in a $^3$He system differs from a free neutron by taking into account nuclear effects such as final state interactions and meson exchange currents. The target single spin asymmetry $A_y^0$ is an ideal probe of such effects, as any deviation from zero indicates effects beyond plane wave impulse approximation. New measurements of the target single spin asymmetry $A_y^0$ at $Q^2$ of 0.46 and 0.96 (GeV/$c)^2$ were made at Jefferson Lab using the quasi-elastic $^3\mathrm{He}^{\uparrow}(e,e'n)$ reaction. Our measured asymmetry decreases rapidly, from $>20\%$ at $Q^2=0.46$ (GeV/$c)^2$ to nearly zero at $Q^2=0.96$ (GeV$/c)^2$, demonstrating the fall-off of the reaction mechanism effects as $Q^2$ increases. We also observed a small $\epsilon$-dependent increase in $A_y^0$ compared to previous measurements, particularly at moderate $Q^2$. This indicates that upcoming high $Q^2$ measurements from the Jefferson Lab 12 GeV program can cleanly probe neutron structure from polarized $^3$He using plane wave impulse approximation., Comment: 6 pages, 5 figures
Published: 2019
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39. Superconducting states and Majorana modes in transition-metal dichalcogenides under inhomogeneous strain

Author: Deng, Ming-Xun, Qi, G. Y., Luo, W., Ma, R., Wang, Rui-Qiang, Shen, R., and Sheng, L.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We study the effect of inhomogeneous strain on transition-metal dichalcogenides with a large intrinsic gap in their spectrum. It is found that, by tuning the chemical potential, superconductivity can preserve within the strain-induced discrete pseudo Landau levels (LLs), which introduce interesting topological properties to these systems. As we show, the superconductivity for integer fillings is quantum critical, and the quantum critical coupling strength is determined by the spacing between the two LLs closest to the Fermi level. For partial fillings, the superconducting gap is scaled linearly with the coupling strength, and decreases rapidly when the chemical potential shifts away from the middle of each LL. In the presence of a Zeeman field, a pair of Majorana modes emerge simultaneously in the two valleys of strained dichalcogenides. When valley symmetry is further destroyed, a single Majorana mode can be expected to emerge at the edges of the strained monolayer dichalcogenides., Comment: Accepted by Phys. Rev. B
Published: 2019
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40. Reducing Interanalyst Variability in Photovoltaic Degradation Rate Assessments

Author: Jordan, DC, Deline, C, Deceglie, MG, Nag, A, Kimball, GM, Shinn, AB, John, JJ, Alnuaimi, AA, Elnosh, ABA, Luo, W, Jain, A, Saleh, MU, Von Korff, H, Hu, Y, Jaubert, JN, and Mavromatakis, F
Subjects: Quantum Physics, Electrical and Electronic Engineering, Materials Engineering
Abstract: The economic return on investment of a commercial photovoltaic system depends greatly on its performance over the long term and, hence, its degradation rate. Many methods have been proposed for assessing system degradation rates from outdoor performance data. However, comparing reported values from one analyst and research group to another requires a common baseline of performance; consistency between methods and analysts can be a challenge. An interlaboratory study was conducted involving different volunteer analysts reporting on the same photovoltaic performance data using different methodologies. Initial variability of the reported degradation rates was so high that analysts could not come to a consensus whether a system degraded or not. More consistent values are received when written guidance is provided to each analyst. Further improvements in analyst variance was accomplished by using the free open-source software RdTools, allowing a reduction in variance between analysts by more than two orders of magnitude over the first round, where multiple analysis methods are allowed. This article highlights many pitfalls in conducting 'routine' degradation analysis, and it addresses some of the factors that must be considered when comparing degradation results reported by different analysts or methods.
Published: 2020

41. The $\gamma$-ray strength function for Thallium isotopes relevant to the $^{205}$Pb - $^{205}$Tl chronometry

Author: Utsunomiya, H., Renstrøm, T., Tveten, G. M., Goriely, S., Ari-izumi, T., Filipescu, D., Kaur, J., Lui, Y. -W., Luo, W., Miyamoto, S., Larsen, A. C., Hilaire, S., Péru, S., and Koning, A. J.
Subjects: Nuclear Experiment
Abstract: Photoneutron cross sections were measured for $^{203}$Tl and $^{205}$Tl at energies between the one- and two-neutron thresholds using quasi-monochromatic $\gamma$-ray beams produced in laser Compton-scattering at the NewSUBARU synchrotron radiation facility. Our new measurement results in cross sections significantly different from the previously reported bremsstrahlung experiment, leading to rather different GDR parameters, in particular to lower GDR peak energies and higher peak cross sections. The photoneutron data are used to constrain the $\gamma$-ray strength function on the basis of the Hartree-Fock-Bogolyubov plus quasi-particle random phase approximation using the Gogny D1M interaction. Supplementing the experimentally constrained $\gamma$-ray strength function with the zero-limit E1 and M1 contributions for the de-excitation mode, we estimate the Maxwellian-averaged cross section for the s-process branching-point nucleus $^{204}$Tl in the context of the $^{205}$Pb - $^{205}$Tl chronometry., Comment: 8 pages, 10 figures, to be submitted to PRC
Published: 2018
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42. Determination of the photodisintegration reaction rates involving charged particles: systematical calculations and proposed measurements based on Extreme Light Infrastructure - Nuclear Physics (ELI-NP)

Author: Lan, H. Y., Xu, Y., Luo, W., Balabanski, D. L., Goriely, S., La Cognata, M., Matei, C., Anzalone, A., Chesnevskaya, S., Guardo, G. L., Lattuada, D., Pizzone, R. G., Romano, S., Spitaleri, C., Taffara, A., Tumino, A., and Zhu, Z. C.
Subjects: Nuclear Theory, Astrophysics - Solar and Stellar Astrophysics, Nuclear Experiment
Abstract: Photodisintegration reaction rates involving charged particles are of relevance to the p-process nucleosynthesis that aims at explaining the production of the stable neutron-deficient nuclides heavier than iron. In this study, the cross sections and astrophysical rates of (g,p) and (g,a) reactions for about 3000 target nuclei with 10
Published: 2018
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43. Sensitization to Furry Animals in Patients with Suspected Allergic Disease in China: A Multicenter Study

Author: Zhu H, Huang Z, Liu T, An N, Gan H, Huang D, Hao C, Luo W, and Sun B
Subjects: animal allergen, specific immunoglobulin e, cross-sectional survey, suspected allergic patient, Immunologic diseases. Allergy, RC581-607
Abstract: Huiqing Zhu,1,&ast; Zhifeng Huang,1,&ast; Tingting Liu,1 Nairui An,1 Hui Gan,1 Dongming Huang,2 Chuangli Hao,3 Wenting Luo,1 Baoqing Sun1 1Department of Allergy and Clinical Immunology, Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People’s Republic of China; 2Department of Pediatrics, Boai Hospital of Zhongshan City, Zhongshan, 528400, People’s Republic of China; 3Department of Respirology, Children’s Hospital, Soochow University, Suzhou, 215025, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Baoqing Sun; Wenting Luo, Department of Allergy and Clinical Immunology, Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiangxi Road, Guangzhou, 510120, Guangdong, People’s Republic of China, Tel +86 20 8306 2865, Fax +86 20 8306 2729, Email sunbaoqing@vip.163.com; 348307379@qq.comPurpose: An objective of this study was to investigate the allergen sensitization characteristics of cat, dog and horse dander in patients with suspected allergic diseases in different geographical regions of Chinese mainland.Patients and Methods: We invited 2377 patients aged 0– 86 years with suspected allergic diseases to participate in a cross-sectional survey in 11 provinces in China. Combined with the questionnaires and animal-specific IgE levels, we analyzed the epidemiological characteristics and risk factors of furry animal sensitization in different regions and populations of Chinese Mainland.Results: Among the 2377 patients with suspected allergic diseases, 14.9% were sensitized to cat dander, 9.3% to dog dander and 5.5% to horse dander. Animal allergens mainly cause low-level sensitization (class 1– 3). There was a significant correlation between cat, dog and horse dander allergen sIgE, with correlation coefficients (rs) all greater than 0.750. The majority (46.5%) of sIgE-positive patients were sensitized to at least two animal allergens simultaneously. The prevalence of these animals all showed a trend of increasing first and then decreasing with age, and all reached the peak in young adolescence. As for the geographical factors, the sensitization rate of cats and dogs in Western was significantly higher than that in Eastern (cat: 18.4% vs 9.2%, dog: 11.6% vs 5.5%, all P < 0.001), however, no significant differences were found in horses. Aged ≤ 6 years, living in Western, and high animal allergen exposure elevated the risk of cat or dog sensitization. Living on a lower floor (aOR: 0.56) was a protective factor for horse sensitization.Conclusion: In this representative sample of Chinese patients with suspected allergic diseases, there was an apparent geographic variation in sensitization to cats and dogs. Age factor and living in Western also had a significant impact on animal allergen sensitization rate.Keywords: animal allergen, specific immunoglobulin E, cross-sectional survey, suspected allergic patient
Published: 2022

44. Description of Clinical Features and Diagnoses of 444 Cases with Neck-Shoulder-Upper Extremity Pain: A Single-Center Retrospective Review

Author: Zhang H, Luo W, Li C, Zhao J, Zhang Q, and Gu R
Subjects: neck, shoulder, upper extremity, pain, retrospective study, spurling’s test, Medicine (General), R5-920
Abstract: Hongchao Zhang, Wenqi Luo, Chaoyuan Li, Jianhui Zhao, Qiao Zhang, Rui Gu Department of Orthopedics, The Multidisciplinary Consultation Center of Neck Shoulder Upper Extremity, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Qiao Zhang; Rui Gu, Department of Orthopedics, The Multidisciplinary Consultation Center of Neck Shoulder Upper Extremity, China-Japan Union Hospital, Jilin University, No. 126 Xiantai Street, Changchun, Jilin Province, 130033, People’s Republic of China, Tel +86 13578793723 ; +86 13804371075, Fax +86431-89876939, Email zhangqiao@jlu.edu.cn; gurui@jlu.edu.cnPurpose: Neck-shoulder-upper extremity pain (NSUEP) is a frequently occurring clinical constellation of syndromes. However, its etiology is complicated, and the diagnosis is challenging. We aimed to present detailed clinical characteristics and diagnoses of NSUEP from a single center and heighten clinicians’ understanding of this condition.Patients and Methods: Prospectively collected databases were used to retrospectively evaluate patients with NSUEP who underwent treatment at the multidisciplinary consultation center for neck, shoulder, and upper extremity pain at the China-Japan Union Hospital of Jilin University between April 2014 and July 2021. We performed descriptive statistics regarding demographic data, symptoms, findings of physical and radiographic examinations, and each patient’s diagnosis.Results: Development of NSUEP was primarily observed in individuals aged between 51 and 60 years (n = 157, 35.4%). Patients were most commonly referred for upper extremity pain (n = 306, 68.9%). Patients with upper extremity pain presented with hypoesthesia (n = 139, 45.4%), muscle weakness (n = 93, 30.4%), muscle atrophy (n = 90, 29.4%), hyperesthesia (n = 39, 12.7%), and turgidity (n = 18, 5.9%). Among the 22 patients with upper extremity swelling, 8 (36.4%) were diagnosed with autoimmune rheumatic diseases. Among the 352 patients with a single diagnosis, 51 (14.5%) presented with thoracic outlet syndrome, 49 (13.9%) with cervical radiculopathy, 16 (4.5%) with carpal tunnel syndrome, and 16 (4.5%) with brachial plexus injury. Further, among the 92 patients with compound diagnosis, 18 patients (19.6%) were diagnosed with cervical radiculopathy.Conclusion: Among the NSUEP patients in this study, older individuals were the largest group. Pain, numbness, weakness, and mobility limitation are common complaints accompanying NSUEP. The common etiologies of NSUEP include cervical spondylosis, thoracic outlet syndrome, carpal tunnel syndrome, and brachial plexus injury. In addition, autoimmune rheumatic diseases should be considered in patients with NSUEP and swelling.Keywords: neck, shoulder, upper extremity, pain, retrospective study, Spurling’s test
Published: 2022

45. Self-Efficacy, Exercise Anticipation and Physical Activity in Elderly: Using Bayesian Networks to Elucidate Complex Relationships

Author: Chen X, Yang S, Zhao H, Li R, Luo W, and Zhang X
Subjects: self-efficacy, physical activity, exercise anticipation, elderly, Medicine (General), R5-920
Abstract: Xiaoying Chen,1,&ast; Shuang Yang,2,&ast; Huiwen Zhao,3 Rui Li,1 Wen Luo,3 Xiuli Zhang3 1The 2nd Ward of Knee Trauma Department, Tianjin Hospital, Tianjin, People’s Republic of China; 2Traumatic Orthopedics Department, The 2nd Ward of Hip Joint Surgery, Tianjin Hospital, Tianjin, People’s Republic of China; 3The 2nd Ward of Joint Surgery, Tianjin Hospital, Tianjin, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wen Luo; Xiuli Zhang, The 2nd Ward of Joint Surgery, Tianjin Hospital, No. 406 Jiefangnan Road, Tianjin, 300211, People’s Republic of China, Tel +86 22-13116190054, Email wl1984@yahoo.com; 13642007171@163.comAim: To explore the correlation of exercise anticipation, self-efficacy and lower limb function in the elderly, and identify active predictors of exercise. The time up and go (TUG) has been used to access basic mobility skills, as well as strength, balance and agility, which is used in a range of population.Methods: A cross-sectional survey approach was employed in this study, assessing the functional relationship of the level of exercise anticipation, modified gait efficacy scale (mGES), self-efficacy for exercise scale (SEE), perceived efficacy of patient–physician interactions (PEPPI-10), behavioral regulation in exercise questionnaire (BREQ), and the time up and go (TUG) and International Physical Activity Questionnaire (IPAQ). Consequently, we constructed the Bayesian network model utilizing Genie 2.3, in order to effectively determine clear negative and positive correlations.Results: This investigation incorporated a total of 285 patients. The results of Spearman’s correlation analysis indicated that the TUG effectively correlated with age (r = 0.158, P < 0.01), drinking (r=− 0.362, P < 0.01), mGES (r=− 0.254, P < 0.01), PEPPI (r=− 0.329, P < 0.01), SEE (r =− 0.408, P < 0.01), BREQ (r = 0.676, P < 0.01), EA (r =− 0.688, P < 0.01) and IPAQ (r =− 0.742, P < 0.01). TUG can be used as the direct influencing factor of IPA, and five nodes in the model can be considered the primary indirect influencing factors of TUG, such as drinking, EA, age, sex and mGES in Bayesian network. The sensitivity analysis of the model confirmed that TUG (0.059), drinking (0.087), EA (0.335), age (0.080), sex (0.164), mGES (0.028) and hypertension (0.030) can become the sensitivity evaluation indicators of IPAQ in the elderly community population, in which the area under the ROC curve (AUC) was 59.6% (2207/3705), indicating a suitable prediction performance.Conclusion: Exercise anticipation and life behavior habit can effectively predict physical activity capability in the elderly. These findings can help clinicians establish effective intervention to improve the physical activity regularly of the elderly.Keywords: self-efficacy, physical activity, exercise anticipation, elderly
Published: 2022

46. Erratum: Measurement of prompt and nonprompt charmonium suppression in PbPb collisions at 5.02 TeV

Author: Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Erö, J., Valle, A. Escalante Del, Flechl, M., Friedl, M., Frühwirth, R., Ghete, V. M., Grossmann, J., Hrubec, J., Jeitler, M., König, A., Krammer, N., Krätschmer, I., Liko, D., Madlener, T., Mikulec, I., Pree, E., Rad, N., Rohringer, H., Schieck, J., Schöfbeck, R., Spanring, M., Spitzbart, D., Waltenberger, W., Wittmann, J., Wulz, C.-E., Zarucki, M., Chekhovsky, V., Mossolov, V., Gonzalez, J. Suarez, De Wolf, E. A., Croce, D. Di, Janssen, X., Lauwers, J., De Klundert, M. Van, Haevermaet, H. Van, Mechelen, P. Van, Remortel, N. Van, Zeid, S. Abu, Blekman, F., D’Hondt, J., De Bruyn, I., De Clercq, J., Deroover, K., Flouris, G., Lontkovskyi, D., Lowette, S., Marchesini, I., Moortgat, S., Moreels, L., Python, Q., Skovpen, K., Tavernier, S., Doninck, W. Van, Mulders, P. Van, Parijs, I. Van, Beghin, D., Bilin, B., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Dorney, B., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Kalsi, A. K., Lenzi, T., Luetic, J., Maerschalk, T., Marinov, A., Seva, T., Starling, E., Velde, C. Vander, Vanlaer, P., Vannerom, D., Yonamine, R., Zenoni, F., Cornelis, T., Dobur, D., Fagot, A., Gul, M., Khvastunov, I., Poyraz, D., Roskas, C., Salva, S., Tytgat, M., Verbeke, W., Zaganidis, N., Bakhshiansohi, H., Bondu, O., Brochet, S., Bruno, G., Caputo, C., Caudron, A., David, P., De Visscher, S., Delaere, C., Delcourt, M., Francois, B., Giammanco, A., Komm, M., Krintiras, G., Lemaitre, V., Magitteri, A., Mertens, A., Musich, M., Piotrzkowski, K., Quertenmont, L., Saggio, A., Marono, M. Vidal, Wertz, S., Zobec, J., Júnior, W. L. Aldá, Alves, F. L., Alves, G. A., Brito, L., Junior, M. Correa Martins, Hensel, C., Moraes, A., Pol, M. E., Teles, P. Rebello, Chagas, E. Belchior Batista Das, Carvalho, W., Chinellato, J., Coelho, E., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Souza, S. Fonseca, Guativa, L. M. Huertas, Malbouisson, H., De Almeida, M. Melo, Herrera, C. Mora, Mundim, L., Nogima, H., Rosas, L. J. Sanchez, Santoro, A., Sznajder, A., Thiel, M., Manganote, E. J. Tonelli, Da Silva De Araujo, F. Torres, Pereira, A. Vilela, Ahuja, S., Bernardes, C. A., Tomei, T. R. Fernandez Perez, Gregores, E. M., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Abad, D. Romero, Vargas, J. C. Ruiz, Aleksandrov, A., Hadjiiska, R., Iaydjiev, P., Misheva, M., Rodozov, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Fang, W., Gao, X., Yuan, L., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Chen, Y., Jiang, C. H., Leggat, D., Liao, H., Liu, Z., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, C., Wang, Z., Yazgan, E., Zhang, H., Zhang, S., Zhao, J., Ban, Y., Chen, G., Li, J., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Zhang, F., Wang, Y., Avila, C., Cabrera, A., Montoya, C. A. Carrillo, Sierra, L. F. Chaparro, Florez, C., Hernández, C. F. González, Alvarez, J. D. Ruiz, Delgado, M. A. Segura, Courbon, B., Godinovic, N., Lelas, D., Puljak, I., Cipriano, P. M. Ribeiro, Sculac, T., Antunovic, Z., Kovac, M., Brigljevic, V., Ferencek, D., Kadija, K., Mesic, B., Starodumov, A., Susa, T., Ather, M. W., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Finger, M., Finger, Jr., M., Jarrin, E. Carrera, Mahmoud, M. A., Mohammed, Y., Salama, E., Dewanjee, R. K., Kadastik, M., Perrini, L., Raidal, M., Tiko, A., Veelken, C., Eerola, P., Kirschenmann, H., Pekkanen, J., Voutilainen, M., Havukainen, J., Heikkilä, J. K., Järvinen, T., Karimäki, V., Kinnunen, R., Lampén, T., Lassila-Perini, K., Laurila, S., Lehti, S., Lindén, T., Luukka, P., Siikonen, H., Tuominen, E., Tuominiemi, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Ghosh, S., Gras, P., de Monchenault, G. Hamel, Jarry, P., Kucher, I., Leloup, C., Locci, E., Machet, M., Malcles, J., Negro, G., Rander, J., Rosowsky, A., Sahin, M.Ö., Titov, M., Abdulsalam, A., Amendola, C., Antropov, I., Baffioni, S., Beaudette, F., Busson, P., Cadamuro, L., Charlot, C., de Cassagnac, R. Granier, Jo, M., Lisniak, S., Lobanov, A., Blanco, J. Martin, Nguyen, M., Ochando, C., Ortona, G., Paganini, P., Pigard, P., Salerno, R., Sauvan, J. B., Sirois, Y., Leiton, A. G. Stahl, Strebler, T., Yilmaz, Y., Zabi, A., Zghiche, A., Agram, J.-L., Andrea, J., Bloch, D., Brom, J.-M., Buttignol, M., Chabert, E. C., Chanon, N., Collard, C., Conte, E., Coubez, X., Fontaine, J.-C., Gelé, D., Goerlach, U., Jansová, M., Bihan, A.-C. Le, Tonon, N., Hove, P. Van, Gadrat, S., Beauceron, S., Bernet, C., Boudoul, G., Chierici, R., Contardo, D., Depasse, P., Mamouni, H. El, Fay, J., Finco, L., Gascon, S., Gouzevitch, M., Grenier, G., Ille, B., Lagarde, F., Laktineh, I. B., Lethuillier, M., Mirabito, L., Pequegnot, A. L., Perries, S., Popov, A., Sordini, V., Donckt, M. Vander, Viret, S., Toriashvili, T., Tsamalaidze, Z., Autermann, C., Feld, L., Kiesel, M. K., Klein, K., Lipinski, M., Preuten, M., Schomakers, C., Schulz, J., Teroerde, M., Zhukov, V., Albert, A., Dietz-Laursonn, E., Duchardt, D., Endres, M., Erdmann, M., Erdweg, S., Esch, T., Fischer, R., Güth, A., Hamer, M., Hebbeker, T., Heidemann, C., Hoepfner, K., Knutzen, S., Merschmeyer, M., Meyer, A., Millet, P., Mukherjee, S., Pook, T., Radziej, M., Reithler, H., Rieger, M., Scheuch, F., Teyssier, D., Thüer, S., Flügge, G., Kargoll, B., Kress, T., Künsken, A., Müller, T., Nehrkorn, A., Nowack, A., Pistone, C., Pooth, O., Stahl, A., Martin, M. Aldaya, Arndt, T., Asawatangtrakuldee, C., Beernaert, K., Behnke, O., Behrens, U., Martínez, A. Bermúdez, Anuar, A. A. Bin, Borras, K., Botta, V., Campbell, A., Connor, P., Contreras-Campana, C., Costanza, F., Pardos, C. Diez, Eckerlin, G., Eckstein, D., Eichhorn, T., Eren, E., Gallo, E., Garcia, J. Garay, Geiser, A., Luyando, J. M. Grados, Grohsjean, A., Gunnellini, P., Guthoff, M., Harb, A., Hauk, J., Hempel, M., Jung, H., Kasemann, M., Keaveney, J., Kleinwort, C., Korol, I., Krücker, D., Lange, W., Lelek, A., Lenz, T., Leonard, J., Lipka, K., Lohmann, W., Mankel, R., Melzer-Pellmann, I.-A., Meyer, A. B., Mittag, G., Mnich, J., Mussgiller, A., Ntomari, E., Pitzl, D., Raspereza, A., Savitskyi, M., Saxena, P., Shevchenko, R., Stefaniuk, N., Onsem, G. P. Van, Walsh, R., Wen, Y., Wichmann, K., Wissing, C., Zenaiev, O., Aggleton, R., Bein, S., Blobel, V., Vignali, M. Centis, Dreyer, T., Garutti, E., Gonzalez, D., Haller, J., Hinzmann, A., Hoffmann, M., Karavdina, A., Klanner, R., Kogler, R., Kovalchuk, N., Kurz, S., Lapsien, T., Marconi, D., Meyer, M., Niedziela, M., Nowatschin, D., Pantaleo, F., Peiffer, T., Perieanu, A., Scharf, C., Schleper, P., Schmidt, A., Schumann, S., Schwandt, J., Sonneveld, J., Stadie, H., Steinbrück, G., Stober, F. M., Stöver, M., Tholen, H., Troendle, D., Usai, E., Vanhoefer, A., Vormwald, B., Akbiyik, M., Barth, C., Baselga, M., Baur, S., Butz, E., Caspart, R., Chwalek, T., Colombo, F., De Boer, W., Dierlamm, A., Faltermann, N., Freund, B., Friese, R., Giffels, M., Harrendorf, M. A., Hartmann, F., Heindl, S. M., Husemann, U., Kassel, F., Kudella, S., Mildner, H., Mozer, M. U., Müller, Th., Plagge, M., Quast, G., Rabbertz, K., Schröder, M., Shvetsov, I., Sieber, G., Simonis, H. J., Ulrich, R., Wayand, S., Weber, M., Weiler, T., Williamson, S., Wöhrmann, C., Wolf, R., Anagnostou, G., Daskalakis, G., Geralis, T., Kyriakis, A., Loukas, D., Topsis-Giotis, I., Karathanasis, G., Kesisoglou, S., Panagiotou, A., Saoulidou, N., Kousouris, K., Evangelou, I., Foudas, C., Gianneios, P., Katsoulis, P., Kokkas, P., Mallios, S., Manthos, N., Papadopoulos, I., Paradas, E., Strologas, J., Triantis, F. A., Tsitsonis, D., Csanad, M., Filipovic, N., Pasztor, G., Surányi, O., Veres, G. I., Bencze, G., Hajdu, C., Horvath, D., Hunyadi, Á., Sikler, F., Veszpremi, V., Beni, N., Czellar, S., Karancsi, J., Makovec, A., Molnar, J., Szillasi, Z., Bartók, M., Raics, P., Trocsanyi, Z. L., Ujvari, B., Choudhury, S., Komaragiri, J. R., Bahinipati, S., Bhowmik, S., Mal, P., Mandal, K., Nayak, A., Sahoo, D. K., Sahoo, N., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V., Chawla, R., Dhingra, N., Kaur, A., Kaur, M., Kaur, S., Kumar, R., Kumari, P., Mehta, A., Singh, J. B., Walia, G., Kumar, Ashok, Shah, Aashaq, Bhardwaj, A., Chauhan, S., Choudhary, B. C., Garg, R. B., Keshri, S., Kumar, A., Malhotra, S., Naimuddin, M., Ranjan, K., Sharma, R., Bhardwaj, R., Bhattacharya, R., Bhattacharya, S., Bhawandeep, U., Dey, S., Dutt, S., Dutta, S., Ghosh, S., Majumdar, N., Modak, A., Mondal, K., Mukhopadhyay, S., Nandan, S., Purohit, A., Roy, A., Chowdhury, S. Roy, Sarkar, S., Sharan, M., Thakur, S., Behera, P. K., Chudasama, R., Dutta, D., Jha, V., Kumar, V., Mohanty, A. K., Netrakanti, P. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Dugad, S., Mahakud, B., Mitra, S., Mohanty, G. B., Sur, N., Sutar, B., Banerjee, S., Bhattacharya, S., Chatterjee, S., Das, P., Guchait, M., Jain, Sa., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Sarkar, T., Wickramage, N., Chauhan, S., Dube, S., Hegde, V., Kapoor, A., Kothekar, K., Pandey, S., Rane, A., Sharma, S., Chenarani, S., Tadavani, E. Eskandari, Etesami, S. M., Khakzad, M., Najafabadi, M. Mohammadi, Naseri, M., Mehdiabadi, S. Paktinat, Hosseinabadi, F. Rezaei, Safarzadeh, B., Zeinali, M., Felcini, M., Grunewald, M., Abbrescia, M., Calabria, C., Colaleo, A., Creanza, D., Cristella, L., De Filippis, N., De Palma, M., Errico, F., Fiore, L., Iaselli, G., Lezki, S., Maggi, G., Maggi, M., Miniello, G., My, S., Nuzzo, S., Pompili, A., Pugliese, G., Radogna, R., Ranieri, A., Selvaggi, G., Sharma, A., Silvestris, L., Venditti, R., Verwilligen, P., Abbiendi, G., Battilana, C., Bonacorsi, D., Borgonovi, L., Braibant-Giacomelli, S., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Chhibra, S. S., Codispoti, G., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F. L., Perrotta, A., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Albergo, S., Costa, S., Mattia, A. 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A., Akchurin, N., Damgov, J., De Guio, F., Dudero, P. R., Faulkner, J., Gurpinar, E., Kunori, S., Lamichhane, K., Lee, S. W., Libeiro, T., Mengke, T., Muthumuni, S., Peltola, T., Undleeb, S., Volobouev, I., Wang, Z., Greene, S., Gurrola, A., Janjam, R., Johns, W., Maguire, C., Melo, A., Ni, H., Padeken, K., Sheldon, P., Tuo, S., Velkovska, J., Xu, Q., Arenton, M. W., Barria, P., Cox, B., Hirosky, R., Joyce, M., Ledovskoy, A., Li, H., Neu, C., Sinthuprasith, T., Wang, Y., Wolfe, E., Xia, F., Harr, R., Karchin, P. E., Poudyal, N., Sturdy, J., Thapa, P., Zaleski, S., Brodski, M., Buchanan, J., Caillol, C., Dasu, S., Dodd, L., Duric, S., Gomber, B., Grothe, M., Herndon, M., Hervé, A., Hussain, U., Klabbers, P., Lanaro, A., Levine, A., Long, K., Loveless, R., Ruggles, T., Savin, A., Smith, N., Smith, W. H., Taylor, D., and Woods, N.
Published: 2023
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47. The Novel Mechanism of Action of GEn-1124, A Next-generation Non-catalytic P38alpha/MK2 Signal Modifier With Endothelial-barrier-stabilizing, Anti-inflammatory, and Lung-protective Activities

Author: Tulapurkar, M., primary, Shapiro, P., additional, Lugkey, K., additional, McClean, N., additional, Fletcher, S., additional, Mackerell, A., additional, Luo, W., additional, Dholakia, S., additional, Lal, R., additional, and Hasday, J.D., additional
Published: 2024
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48. Novel Next-generation Non-catalytic P38alpha/MK2 Immunomodulators With Endothelial-barrier-stabilizing and Anti-inflammatory Activity

Author: Tulapurkar, M., primary, Lugkey, K., additional, Shapiro, P., additional, Fletcher, S., additional, Mackerell, A., additional, Luo, W., additional, Dholakia, S., additional, Lal, R., additional, and Hasday, J.D., additional
Published: 2024
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49. Impact of Chronic Obstructive Pulmonary Disease on the Prognosis of Patients With Lung Cancer

Author: Luo, W., primary, Gan, J., additional, and Li, W., additional
Published: 2024
Full Text: View/download PDF

50. Surgical Outcomes of Synchronous Multiple Primary Lung Cancers With More Than Three Lesions

Author: Luo, W., primary, Wang, T., additional, and Li, W., additional
Published: 2024
Full Text: View/download PDF

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