Search

The continuous annealing treatment of 5052 aluminum alloy pipe fittings for alpine skiing sticks was carried out in the temperature range of 300-500 °C by means of metallographic observation and mechanical property test. The results show that with the increase of annealing temperature, the strength and hardness of the samples decrease continuously, and the impact value, section shrinkage and elongation change significantly. The experimental results provide a technical reference for preventing the fracture of alpine skiing sticks during use. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Prostate cancer is one of the most common malignant tumors. Recently, the role of long noncoding RNAs (lncRNAs) in tumor progression has been well concerned by numerous researchers. In this research, lncRNA TTN-AS1 was studied to identify its biological function in the progression of prostate cancer. PATIENTS AND METHODS: Firstly, Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was conducted to measure TTN-AS1 expression in prostate cancer tissues. Furthermore, in vitro role of TTN-AS1 in regulating prostate cancer cells was assessed. Tumor formation assay was conducted in NOD/SCID mice to explore the in vitro function of TTN-AS1. In addition, the luciferase reporter gene assay was performed to analyze the relationship between TTN-AS1 and miR-1271. RESULTS: TTN-AS1 expression was remarkably higher in prostate cancer samples compared with that of corresponding ones. Moreover, proliferation and migration of prostate cancer cells were inhibited after TTN-AS1 was silenced. MiR-1271 was upregulated after the silence of TTN-AS1. Further mechanism assays showed that miR-1271 was a direct target of TTN-AS1 in prostate cancer. In addition, tumor formation and metastasis abilities were inhibited after in vivo knockdown of TTN-AS1. CONCLUSIONS: Our study discovers a potential oncogene in prostate cancer and demonstrates that TTN-AS1 enhances cell proliferation and migration via sponging miR-1271. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRTPCR) assay to assess the OXTR and ZEB1 mRNA levels. RESULTS: The OXTR mRNA level was higher in the group B than in the groups A and C and the ZEB1 mRNA level was lower in the group B than in the groups A and C. Notably, no significant difference was found in the mRNA level of OXTR or ZEB1 between group A and group C. CONCLUSIONS: The peripheral blood mRNA level of OXTR was increased and that of ZEB1 was decreased in pregnant women with threatened premature labor. Progesterone helped to maintain pregnancy by readjusting the mRNA levels of OXTR and ZEB1. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The present study aimed to investigate the effectiveness of atosiban in treating women with threatened preterm labor who had become pregnant through assisted reproductive technology (ART) and the corresponding pregnancy outcomes. PATIENTS AND METHODS: Seventy pregnant women with threatened preterm labor after ART were randomly divided into two groups, with 35 cases in the atosiban group and 35 in the ritodrine group. The post-treatment effects and the corresponding pregnancy outcomes were observed. RESULTS: The efficacy of extending gestational age by 48 hours was significantly higher in the atosiban group than in the ritodrine group (p<0.05), whereas the efficacy of extending gestational age by seven days was the same in the two groups (p>0.05). There was no significant difference between the atosiban and ritodrine groups in the average gestational age at birth (p<0.05). The occurrence of side effects in the pregnant women was higher in the ritodrine group than in the atosiban group (p<0.05), although the prevalence of abnormal fetal heart rate was not significantly different (p>0.05). Both the perinatal mortality rate and the prevalence of neonatal asphyxia were significantly lower in the atosiban group than in the ritodrine group (p<0.05). When the medication was applied at a gestational age of fewer than 28 weeks, the perinatal mortality rate and the prevalence of neonatal pneumonia were significantly lower in the atosiban group compared with the ritodrine group (p<0.05). When the first drug administration was at a gestational age of 28 weeks or later, the need for neonatal pediatric treatment was significantly reduced in the atosiban group relative to the ritodrine group. Independent of when the drug administration was initiated, there were no significant differences between the atosiban and ritodrine groups in the occurrences of neonatal asphyxia, acute respiratory distress syndrome (ARDS), neonatal brain injury, or neonatal sepsis (p>0.05). CONCLUSIONS: Administration of atosiban has a comparatively better effect than that of ritodrine on pregnant women who underwent ART and is safe and effective at preventing immediate preterm birth. Atosiban is significantly better than ritodrine at reducing the rates of perinatal mortality and neonatal pneumonia, and the perinatal outcomes for those who began to use atosiban at a gestational age of fewer than 28 weeks were even better. [ABSTRACT FROM AUTHOR]