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196 results on '"Luo Simin"'

1. C-to-G editing generates double-strand breaks causing deletion, transversion and translocation

Author

Huang, Min Emma, Qin, Yining, Shang, Yafang, Hao, Qian, Zhan, Chuanzong, Lian, Chaoyang, Luo, Simin, Liu, Liu Daisy, Zhang, Senxin, Zhang, Yu, Wo, Yang, Li, Niu, Wu, Shuheng, Gui, Tuantuan, Wang, Binbin, Luo, Yifeng, Cai, Yanni, Liu, Xiaojing, Xu, Ziye, Dai, Pengfei, Li, Simiao, Zhang, Liang, Dong, Junchao, Wang, Jian, Zheng, Xiaoqi, Xu, Yingjie, Sun, Yihua, Wu, Wei, Yeap, Leng-Siew, and Meng, Fei-Long

Published
2024
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16. Assessing real-world safety concerns of Sacituzumab govitecan: a disproportionality analysis using spontaneous reports in the FDA adverse event reporting system

Author

Gui, Xiujuan, primary, Zhao, Jianli, additional, Ding, Linxiaoxiao, additional, Chai, Jie, additional, Lai, Hongna, additional, Cai, Yangyang, additional, Luo, Simin, additional, Zeng, Yinduo, additional, Wu, Wenjing, additional, Chen, Haizhu, additional, Yao, Herui, additional, and Wang, Ying, additional

Published
2023
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19. Large-Scale Electric Vehicle Energy Demand Considering Weather Conditions and Onboard Technology

Author

Luo, Simin, Tian, Yan, Zheng, Wei, Zhang, Xiaoheng, Zhang, Jingxia, Zhou, Bowen, Barbosa, Simone Diniz Junqueira, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Li, Kang, editor, Zhang, Jianhua, editor, Chen, Minyou, editor, Yang, Zhile, editor, and Niu, Qun, editor

Published
2018
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29. Abstract P4-01-21: Phase 2 Study of the CDK4/6 Inhibitor FCN-437c in Combination With Fulvestrant or Letrozole and Goserelin in Patients With HR+, HER2– Advanced Breast Cancer

Author

Shi, JiaJie, primary, Li, Wei, additional, Tong, Zhongsheng, additional, Zang, Aimin, additional, Zeng, Xiaohua, additional, Wang, Shui, additional, Huang, Tao, additional, Wang, Ying, additional, Song, Yanqiu, additional, Kang, Lihua, additional, Lv, Zheng, additional, Shi, Yehui, additional, Yang, Hua, additional, Wu, Jing, additional, Yin, Yongmei, additional, Liang, Yan, additional, Tan, Jie, additional, Ming, Jie, additional, Yang, Yaping, additional, Luo, Simin, additional, Gui, Xiujuan, additional, Hui, Ai-Min, additional, Wu, Zhuli, additional, Tian, Ling, additional, Yang, Yuchen, additional, Diao, Lei, additional, Zhang, Wenjing, additional, Zhang, Yongjiao, additional, and Liu, Yunjiang, additional

Published
2023
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37. Cationic solid lipid nanoparticles loaded by integrin β1 plasmid DNA attenuates IL-1β-induced apoptosis of chondrocyte

Author

Zhao, Yuejiang, Chen, Hanwen, Wang, Lu, Guo, Zhiyuan, Liu, Shijie, and Luo, Simin

Subjects
integrin β1, Interleukin-1beta, chondrocytes, Apoptosis, DNA, Rats, body regions, osteoarthritis, Liposomes, Animals, Nanoparticles, cationic solid lipid nanoparticles, Cells, Cultured, Research Paper, Plasmids
Abstract

Aging-related inflammation is tightly linked with the development of osteoarthritis (OA). As the pro-inflammatory cytokine, IL-1β has been associated with physical dysfunction and frailty. It is still elusive whether and how IL-1β blockade improves the outcome of OA. Here we develop a cationic solid lipid nanoparticles (SLNs) system that effectively mediate non-viral delivery of plasmid DNA (pDNA) into cells. Compared with other DNA transfer technologies including lipofetamin 2000, SLNs-pDNA system is less toxic and exerts identical effectiveness on DNA transfer. Loaded with integrin β1 overexpression pDNA, the SLNs-pDNA mainly localized in cytoplasm and enforced expression of integrin β1 in rat chondrocytes. Moreover, upon exposure to IL-1β stimulation, SLNs-pDNA treatment attenuates the apoptosis rat chondrocytes and augments tissue repair. Our data thus demonstrate that SLNs-pDNA functions as a potential therapeutic nanomedicine in the treatment of osteoarthritis.

Published
2020

38. DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.

Author

Hao, Qian, Zhan, Chuanzong, Lian, Chaoyang, Luo, Simin, Cao, Wenyi, Wang, Binbin, Xie, Xia, Ye, Xiaofei, Gui, Tuantuan, Voena, Claudia, Pighi, Chiara, Wang, Yanyan, Tian, Ying, Wang, Xin, Dai, Pengfei, Cai, Yanni, Liu, Xiaojing, Ouyang, Shengqun, Sun, Shiqi, and Hu, Qianwen

Abstract

Insertions and deletions (indels) are low-frequency deleterious genomic DNA alterations. Despite their rarity, indels are common, and insertions leading to long complementarity-determining region 3 (CDR3) are vital for antigen-binding functions in broadly neutralizing and polyreactive antibodies targeting viruses. Because of challenges in detecting indels, the mechanism that generates indels during immunoglobulin diversification processes remains poorly understood. We carried out ultra-deep profiling of indels and systematically dissected the underlying mechanisms using passenger-immunoglobulin mouse models. We found that activation-induced cytidine deaminase–dependent ±1–base pair (bp) indels are the most prevalent indel events, biasing deleterious outcomes, whereas longer in-frame indels, especially insertions that can extend the CDR3 length, are rare outcomes. The ±1-bp indels are channeled by base excision repair, but longer indels require additional DNA-processing factors. Ectopic expression of a DNA exonuclease or perturbation of the balance of DNA polymerases can increase the frequency of longer indels, thus paving the way for models that can generate antibodies with long CDR3. Our study reveals the mechanisms that generate beneficial and deleterious indels during the process of antibody somatic hypermutation and has implications in understanding the detrimental genomic alterations in various conditions, including tumorigenesis. Immunoglobulin indel insights: Insertions and deletions (indels) are genomic DNA alterations that are critical to the emergence of a long complementarity determining region 3 (CDR3), which is a key step during immunoglobulin diversification. Indels have been notoriously difficult to detect, thus making it difficult to define mechanisms involved in this process. Hao et al. developed passenger-immunoglobulin mouse models to carry out ultra-deep profiling of indels. They observed that activation-induced cytidine deaminase (AID)–dependent ±1 bp indel events were the most common and involved base excision repair. In contrast, longer in-frame indels, such as those associated with CDR3 lengthening, were rare and required other DNA processing molecules. They were also able to increase indel frequencies through ectopic expression of a DNA exonuclease or changes in the balance of DNA polymerases, thus suggesting a method for generating antibodies with enhanced neutralization. —CNF [ABSTRACT FROM AUTHOR]

Published
2023
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39. Asynchronous Control for Markov Switching Lur’e Systems With Round-Robin Protocol

Author

Hongbin Wang, Luo Simin, Le Luan, Zhong Xu, Wenxiong Mo, and Cui Yiping

Subjects
0209 industrial biotechnology, Schedule, General Computer Science, Markov chain, Observer (quantum physics), Computer science, General Engineering, Markov process, 02 engineering and technology, symbols.namesake, 020901 industrial engineering & automation, Control theory, Asynchronous communication, 0202 electrical engineering, electronic engineering, information engineering, symbols, 020201 artificial intelligence & image processing, General Materials Science, Electrical and Electronic Engineering, Hidden Markov model, Communication channel
Abstract

This paper addresses the asynchronous control design problem for discrete-time Markov switching Lur’e systems. First, to schedule the information transmission and data collisions by the limited shared channel, the round-robin protocol is adopted in scheduling the information exchange order. Second, considering that the system mode cannot be identified to controller, a mode observer is employed to evaluate the system mode by menas of a hidden Markov model. To address this issue, the mode-dependent stochastic Lur’e type Lyapunov functional is analyzed, and several sufficient criteria with prescribed performance are attained to guarantee the stochastically stable of the resulting discrete-time MSLSs. Finally, the effectiveness and applicability of the gained technique is verified by a practical example.

Published
2020

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