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1. Fairness and pitfalls of the Italian waiting list for elective liver transplantation: The ECALITA registry study

Author

Manzia, Tommaso Maria, Trapani, Silvia, Nardi, Alessandra, Ricci, Andrea, Lenci, Ilaria, Sensi, Bruno, Angelico, Roberta, De Feo, Tullia Maria, Agnes, Salvatore, Andorno, Enzo, Baccarani, Umberto, Carraro, Amedeo, Cescon, Matteo, Cillo, Umberto, Colledan, Michele, Pinelli, Domenico, De Carlis, Luciano, De Simone, Paolo, Ghinolfi, Davide, Benedetto, Fabrizio Di, Ettorre, Giuseppe Maria, Gruttadauria, Salvatore, Lupo, Luigi Giovanni, Tandoi, Francesco, Mazzaferro, Vincenzo, Romagnoli, Renato, Rossi, Giorgio, Caccamo, Lucio, Rossi, Massimo, Spada, Marco, Vennarecci, Giovanni, Vivarelli, Marco, Zamboni, Fausto, Tisone, Giuseppe, Cardillo, Massimo, and Angelico, Mario

Published
2025
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2. Waiting list mortality and 5-year transplant survival benefit of patients with MASLD: An Italian liver transplant registry study

Author

Vitale, Alessandro, Trapani, Silvia, Russo, Francesco Paolo, Miele, Luca, Svegliati Baroni, Gianluca, Marchesini, Giulio, Burra, Patrizia, Ottoveggio, Marco Salvatore, Romagnoli, Renato, Martini, Silvia, De Simone, Paolo, Carrai, Paola, Cescon, Matteo, Morelli, Maria Cristina, De Carlis, Luciano, Belli, Luca, Gruttadauria, Salvatore, Volpes, Riccardo, Colledan, Michele, Fagiuoli, Stefano, Di Benedetto, Fabrizio, De Maria, Nicola, Rossi, Giorgio, Caccamo, Lucio, Donato, Francesca, Vennarecci, Giovanni, Di Costanzo, Giovan Giuseppe, Vivarelli, Marco, Carraro, Amedeo, Sacerdoti, David, Ettorre, Giuseppe Maria, Giannelli, Valerio, Agnes, Salvatore, Gasbarrini, Antonio, Rossi, Massimo, Ginanni Corradini, Stefano, Mazzaferro, Vincenzo, Bhoori, Sherrie, Manzia, Tommaso Maria, Lenci, Ilaria, Zamboni, Fausto, Mameli, Laura, Baccarani, Umberto, Toniutto, Pierluigi, Lupo, Luigi Giovanni, Tandoi, Francesco, Rendina, Maria, Andorno, Enzo, Giannini, Edoardo Giovanni, Spada, Marco, Billato, Ilaria, Marchini, Andrea, Romano, Pierluigi, Brancaccio, Giuseppina, D’Amico, Francesco, Ricci, Andrea, Cardillo, Massimo, and Cillo, Umberto

Published
2024
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3. Improving outcomes of in situ split liver transplantation in Italy over the last 25 years

Author

Lauterio, Andrea, Cillo, Umberto, Spada, Marco, Trapani, Silvia, De Carlis, Riccardo, Bottino, Giuliano, Bernasconi, Davide, Scalamogna, Chiara, Pinelli, Domenico, Cintorino, Davide, D’Amico, Francesco Enrico, Spagnoletti, Gionata, Miggino, Marco, Romagnoli, Renato, Centonze, Leonardo, Caccamo, Lucio, Baccarani, Umberto, Carraro, Amedeo, Cescon, Matteo, Vivarelli, Marco, Mazaferro, Vincenzo, Ettorre, Giuseppe Maria, Rossi, Massimo, Vennarecci, Giovanni, De Simone, Paolo, Angelico, Roberta, Agnes, Salvatore, Di Benedetto, Fabrizio, Lupo, Luigi Giovanni, Zamboni, Fausto, Zefelippo, Arianna, Patrono, Damiano, Diviacco, Pietro, Laureiro, Zoe Larghi, Gringeri, Enrico, Di Francesco, Fabrizio, Lucianetti, Alessandro, Valsecchi, Maria Grazia, Gruttadauria, Salvatore, De Feo, Tullia, Cardillo, Massimo, De Carlis, Luciano, Colledan, Michele, and Andorno, Enzo

Published
2023
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4. Temporal trends of waitlistings for liver transplantation in Italy: The ECALITA (Evolution of IndiCAtion in LIver transplantation in ITAly) registry study

Author

Manzia, Tommaso Maria, Trapani, Silvia, Nardi, Alessandra, Ricci, Andrea, Lenci, Ilaria, Milana, Martina, Angelico, Roberta, De Feo, Tullia Maria, Agnes, Salvatore, Andorno, Enzo, Baccarani, Umberto, Carraro, Amedeo, Cescon, Matteo, Cillo, Umberto, Colledan, Michele, De Carlis, Luciano, De Simone, Paolo, Di Benedetto, Fabrizio, Ettorre, Giuseppe Maria, Gruttadauria, Salvatore, Lupo, Luigi Giovanni, Mazzaferro, Vincenzo, Romagnoli, Renato, Rossi, Giorgio, Rossi, Massimo, Spada, Marco, Vennarecci, Giovanni, Vivarelli, Marco, Zamboni, Fausto, Tisone, Giuseppe, Cardillo, Massimo, and Angelico, Mario

Published
2022
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5. A national mandatory-split liver policy: A report from the Italian experience

Author

Angelico, Roberta, Trapani, Silvia, Spada, Marco, Colledan, Michele, de Ville de Goyet, Jean, Salizzoni, Mauro, De Carlis, Luciano, Andorno, Enzo, Gruttadauria, Salvatore, Ettorre, Giuseppe Maria, Cescon, Matteo, Rossi, Giorgio, Risaliti, Andrea, Tisone, Giuseppe, Tedeschi, Umberto, Vivarelli, Marco, Agnes, Salvatore, De Simone, Paolo, Lupo, Luigi Giovanni, Di Benedetto, Fabrizio, Santaniello, Walter, Zamboni, Fausto, Mazzaferro, Vincenzo, Rossi, Massimo, Puoti, Francesca, Camagni, Stefania, Grimaldi, Chiara, Gringeri, Enrico, Rizzato, Lucia, Nanni Costa, Alessandro, and Cillo, Umberto

Published
2019
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7. Switch from intravenous or intramuscular to subcutaneous hepatitis B immunoglobulin: effect on quality of life after liver transplantation

Author

Volpes, Riccardo, Burra, Patrizia, Germani, Giacomo, Manini, Matteo Angelo, Caccamo, Lucio, Strignano, Paolo, Rizza, Giorgia, Tamè, Mariarosa, Pinna, Antonio Daniele, Calise, Fulvio, Migliaccio, Carla, Carrai, Paola, De Simone, Paolo, Valentini, Maria Filippa, Lupo, Luigi Giovanni, Cordone, Gabriella, Picciotto, Francesco Paolo, and Nicolucci, Antonio

Published
2020
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8. The Italian data on SARS-CoV-2 infection in transplanted patients support an organ specific immune response in liver recipients

Author

Rendina, Maria, primary, Barone, Michele, additional, Lillo, Chiara, additional, Trapani, Silvia, additional, Masiero, Lucia, additional, Trerotoli, Paolo, additional, Puoti, Francesca, additional, Lupo, Luigi Giovanni, additional, Tandoi, Francesco, additional, Agnes, Salvatore, additional, Grieco, Antonio, additional, Andorno, Enzo, additional, Marenco, Simona, additional, Giannini, Edoardo Giovanni, additional, Baccarani, Umberto, additional, Toniutto, Pierluigi, additional, Carraro, Amedeo, additional, Colecchia, Antonio, additional, Cescon, Matteo, additional, Morelli, Maria Cristina, additional, Cillo, Umberto, additional, Burra, Patrizia, additional, Angeli, Paolo, additional, Colledan, Michele, additional, Fagiuoli, Stefano, additional, De Carlis, Luciano, additional, Belli, Luca, additional, De Simone, Paolo, additional, Carrai, Paola, additional, Di Benedetto, Fabrizio, additional, De Maria, Nicola, additional, Ettorre, Giuseppe Maria, additional, Giannelli, Valerio, additional, Gruttadauria, Salvatore, additional, Volpes, Riccardo, additional, Corsale, Sveva, additional, Mazzaferro, Vincenzo, additional, Bhoori, Sherrie, additional, Romagnoli, Renato, additional, Martini, Silvia, additional, Rossi, Giorgio, additional, Caccamo, Lucio, additional, Donato, Maria Francesca, additional, Rossi, Massimo, additional, Ginanni Corradini, Stefano, additional, Spada, Marco, additional, Maggiore, Giuseppe, additional, Tisone, Giuseppe, additional, Lenci, Ilaria, additional, Vennarecci, Giovanni, additional, Tortora, Raffaella, additional, Vivarelli, Marco, additional, Svegliati Baroni, Gianluca, additional, Zamboni, Fausto, additional, Mameli, Laura, additional, Tafuri, Silvio, additional, Simone, Simona, additional, Gesualdo, Loreto, additional, Cardillo, Massimo, additional, and Di Leo, Alfredo, additional

Published
2023
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11. Impact of SARS-CoV-2 Pandemic on the Management of Patients with Hepatocellular Carcinoma

Author

Maria, Guarino, Valentina, Cossiga, Mario, Capasso, Chiara, Mazzarelli, Filippo, Pelizzaro, Rodolfo, Sacco, Francesco Paolo, Russo, Alessandro, Vitale, Franco, Trevisani, Giuseppe, Cabibbo, Baccarani, Umberto, Bhoori, Sherrie, Borzio, Mauro, Brancaccio, Giuseppina, Burra, Patrizia, Casadei Gardini, Andrea, Carrai, Paola, Centonze, Leonardo, Cescon, Matteo, Cillo, Umberto, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Costanzo, Giovan Giuseppe, Di Sandro, Stefano, Famularo, Simone, Farinati, Fabio, Finotti, Michele, Giuseppe Foschi, Francesco, Galati, Giovanni, Gambato, Martina, Giovanni Giannini, Edoardo, Giuliante, Felice, Ghinolfi, Davide, Gruttaduria, Salvatore, Iavarone, Massimo, Kostandini, Alba, Lai, Quirino, Lenci, Ilaria, Giovanni Lupo, Luigi, Manzia, Tommaso, Marasco, Giovanni, Marenco, Simona, Masarone, Mario, Mazzocato, Susanna, Melandro, Fabio, Mescoli, Claudia, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Persico, Marcello, Platz Torres, Maria Corina, Ponziani, Francesca Romana, Pravisani, Riccardo, Rendina, Maria, Renzulli, Matteo, Ricci, Lilia, Romano, Fabrizio, Battista Levi Sandri, Giovanni, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Viganò, Luca, Viganò, Mauro, Vincenzi, Valter, Violi, Pola, Nicoletta, De Matthaeis, Felice, Giuliante (ORCID:0000-0001-9517-8220), Luca, Miele (ORCID:0000-0003-3464-0068), Francesca Romana, Ponziani (ORCID:0000-0002-5924-6238), Maria, Guarino, Valentina, Cossiga, Mario, Capasso, Chiara, Mazzarelli, Filippo, Pelizzaro, Rodolfo, Sacco, Francesco Paolo, Russo, Alessandro, Vitale, Franco, Trevisani, Giuseppe, Cabibbo, Baccarani, Umberto, Bhoori, Sherrie, Borzio, Mauro, Brancaccio, Giuseppina, Burra, Patrizia, Casadei Gardini, Andrea, Carrai, Paola, Centonze, Leonardo, Cescon, Matteo, Cillo, Umberto, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Costanzo, Giovan Giuseppe, Di Sandro, Stefano, Famularo, Simone, Farinati, Fabio, Finotti, Michele, Giuseppe Foschi, Francesco, Galati, Giovanni, Gambato, Martina, Giovanni Giannini, Edoardo, Giuliante, Felice, Ghinolfi, Davide, Gruttaduria, Salvatore, Iavarone, Massimo, Kostandini, Alba, Lai, Quirino, Lenci, Ilaria, Giovanni Lupo, Luigi, Manzia, Tommaso, Marasco, Giovanni, Marenco, Simona, Masarone, Mario, Mazzocato, Susanna, Melandro, Fabio, Mescoli, Claudia, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Persico, Marcello, Platz Torres, Maria Corina, Ponziani, Francesca Romana, Pravisani, Riccardo, Rendina, Maria, Renzulli, Matteo, Ricci, Lilia, Romano, Fabrizio, Battista Levi Sandri, Giovanni, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Viganò, Luca, Viganò, Mauro, Vincenzi, Valter, Violi, Pola, Nicoletta, De Matthaeis, Felice, Giuliante (ORCID:0000-0001-9517-8220), Luca, Miele (ORCID:0000-0003-3464-0068), and Francesca Romana, Ponziani (ORCID:0000-0002-5924-6238)

Abstract

Worldwide, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly increases mortality and morbidity. The Coronavirus Disease 2019 (COVID-19) outbreak has had a considerable impact on healthcare systems all around the world, having a significant effect on planned patient activity and established care pathways, in order to meet the difficult task of the global pandemic. Patients with hepatocellular carcinoma (HCC) are considered a particularly susceptible population and conceivably at increased risk for severe COVID-19 because of two combined risk factors: chronic advanced liver disease and HCC itself. In these challenging times, it is mandatory to reshape clinical practice in a prompt way to preserve the highest standards of patient care and safety. However, due to the stay-at-home measures instituted to stop the spread of COVID-19, HCC surveillance has incurred a dramatic drop, and care for HCC patients has been rearranged by refining the algorithm for HCC treatment to the COVID-19 pandemic, permitting these patients to be safely managed by identifying those most at risk of neoplastic disease progression.

Published
2022

13. Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching

Author

Angelico, Mario, Cillo, Umberto, Fagiuoli, Stefano, Gasbarrini, Antonio, Gavrila, Caius, Marianelli, Tania, Costa, Alessandro Nanni, Nardi, Alessandra, Strazzabosco, Mario, Burra, Patrizia, Agnes, Salvatore, Baccarani, Umberto, Calise, Fulvio, Colledan, Michele, Cuomo, Oreste, De Carlis, Luciano, Donataccio, Matteo, Ettorre, Giuseppe M., Gerunda, Giorgio E., Gridelli, Bruno, Lupo, Luigi, Mazzaferro, Vincenzo, Pinna, Antonio, Risaliti, Andrea, Salizzoni, Mauro, Tisone, Giuseppe, Valente, Umberto, Rossi, Giorgio, Rossi, Massimo, and Zamboni, Fausto

Published
2011
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15. Effect of direct-acting antivirals on future occurrence of hepatocellular carcinoma in compensated cirrhotic patients

Author

Cucchetti, Alessandro, D’Amico, Gennaro, Trevisani, Franco, Morelli, Maria Cristina, Vitale, Alessandro, Pinna, Antonio Daniele, Cescon, Matteo, Cillo, Umberto, Burra, Patrizia, Russo, Francesco P., Mescoli, Claudia, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Brancaccio, Giusep-Pina, Persico, Marcello, Viganò, Luca, Iavarone, Massimo, D’Ambrosio, Roberta, Sangiovanni, Angelo, Renzulli, Matteo, Galati, Giovanni, Ponziani, Francesca Romana, Pompili, Maurizio, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Lai, Quirino, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Sacco, Rodolfo, Simonetti, Natalia, Morisco, Filomena, Guarino, Maria, Cabibbo, Giuseppe, Bhoori, Carlo Sposito Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, A. Cucchetti, G. D'Amico, F. Trevisani, M.C. Morelli, A. Vitale, A.D.Pinna, M. Cescon, Cucchetti, Alessandro, D’Amico, Gennaro, Trevisani, Franco, Morelli, Maria Cristina, Vitale, Alessandro, Pinna, Antonio Daniele, Cescon, Matteo, Cillo, Umberto, Burra, Patrizia, Russo, Francesco P., Mescoli, Claudia, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Brancaccio, Giusep-Pina, Persico, Marcello, Viganò, Luca, Iavarone, Massimo, D’Ambrosio, Roberta, Sangiovanni, Angelo, Renzulli, Matteo, Galati, Giovanni, Ponziani, Francesca Romana, Pompili, Maurizio, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Lai, Quirino, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Sacco, Rodolfo, Simonetti, Natalia, Morisco, Filomena, Guarino, Maria, Cabibbo, Giuseppe, Bhoori, Carlo Sposito Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, and Pravisani, Riccardo

Subjects
Male, Time Factors, Sustained Virologic Response, Hepatocellular carcinoma, Hepacivirus, Direct-acting antiviral, Direct-acting antivirals, medicine.disease_cause, Gastroenterology, Competing risk, Hepatitis C, Markov model, Survival benefit, Sustained virological response, Hepatology, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, biology, Incidence, Incidence (epidemiology), Liver Neoplasms, Middle Aged, Markov Chains, Competing risk Direct-acting antivirals Hepatitis C Hepatocellular carcinoma Markov model Survival benefit Sustained virological response, Italy, Liver Neoplasm, Female, 030211 gastroenterology & hepatology, Human, Adult, medicine.medical_specialty, Carcinoma, Hepatocellular, Time Factor, Hepatitis C virus, Antiviral Agents, 03 medical and health sciences, Internal medicine, medicine, Humans, Antiviral Agent, Hepaciviru, business.industry, Risk Factor, Carcinoma, Hepatocellular, Markov Chain, medicine.disease, biology.organism_classification, digestive system diseases, Settore MED/18 - Chirurgia Generale, Liver function, Varices, business
Abstract

Background: The achievement of high rates of sustained virological response (SVR) with direct-acting antivirals (DAAs) in hepatitis C virus (HCV) infected patients will reduce decompensating terminal events. Aims: To investigate whether hepatocellular carcinoma (HCC) occurrence could change due to the DAA-induced increase in life-expectancy. Methods: A Markov model was built on clinical data of 494 cirrhotic patients and available literature to estimate probabilities of “death before HCC” and of “HCC occurrence” without and with DAA. Results: In comparison to untreated patients, DAA therapy reduced the 20-year mortality before HCC by 21.9% in patients without varices and by 21.5% in those with varices, considering an SVR of 95% and no direct effect on hepatocarcinogenesis. Tumour occurrence increased by 5%–8.2% and the proportion of HCCs diagnosed in compensated stages increased to >98%. If we consider DAA as having “anti-tumoral” effects, the benefit becomes greater, achieving a 20-year survival of 81.5% in patients without varices, and 52.2% in patients with varices. Instead, if we consider DAA as having a “pro-tumoral” effect, then, the increased incidence of HCC nullifies the survival benefits. Conclusion: DAAs drastically reduce the mortality caused by the liver function worsening, increasing the proportion of HCCs diagnosed in compensated stages. Knowledge of the DAA effect on hepatocarcinogenesis remains pivotal. © 2017 Editrice Gastroenterologica Italiana S.r.l.

Published
2018
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24. Recurrence of hepatocellular carcinoma after direct acting antiviral treatment for hepatitis C virus infection: Literature review and risk analysis

Author

Guarino, Maria, Viganò, Luca, Ponziani, Francesca Romana, Giannini, Edoardo Giovanni, Lai, Quirino, Morisco, Filomena, Vitale, Alessandro, Russo, Francesco Paolo, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Sessa, Anna, Cabibbo, Giuseppe, Viganò, Mauro, Galati, Giovanni, Villa, Erica, Iavarone, Massimo, Brancaccio, Giuseppina, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Cucchetti, Alessandro, Trevisani, Franco, Matteo, Renzulli, Miele, Luca, Grieco, Antonio, Lodovico Rapaccini, Gian, Pompili, Maurizio, Gasbarrini, Antonio, Battisa Levi Sandri, Giovanni, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Sacco, Rodolfo, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Sposito, Carlo, Bhoori, Sherrie, di Sandro, Stefano, Foschi, Francesco Giuseppe, Casadei Gardini, Andrea, Nicolini, Daniele, Mazzocato, Susanna, Kostandini, Alba, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, Vincenzi, Valter, ROSA MARIA, Guarino, Luca, Viganò, Francesca Romana, Ponziani, Edoardo Giovanni, Giannini, Quirino, Lai, Filomena, Morisco, Alessandro, Vitale, Russo, Francesco Paolo, Umberto, Cillo, Patrizia, Burra, Claudia, Mescoli, Martina, Gambato, Anna, Sessa, Cabibbo, Giuseppe, Viganò, Mauro, Galati, Giovanni, Erica, Villa, Iavarone, Massimo, Brancaccio, Giuseppina, Maria, Rendina, Luigi G., Lupo, Francesco, Losito, Fabio, Fucilli, Marcello, Persico, Roberta, D'Ambrosio, Angelo, Sangiovanni, Alessandro, Cucchetti, Franco, Trevisani e Matteo Renzulli, Luca, Miele, Antonio, Grieco, Gian, Lodovico Rapaccini, Maurizio, Pompili, Antonio, Gasbarrini, Giovanni, Battisa Levi Sandri, Fabio, Melandro, Massimo, Rossi, Ilaria, Lenci, Tommaso, Maria Manzia, Raffaella, Tortora, Giovan Giuseppe, Di Costanzo, Sacco, Rodolfo, Davide, Ghinolfi, Erion, Rreka, Paola, Carrai, Natalia, Simonetti, Carlo, Sposito, Sherrie, Bhoori, Stefano, di Sandro, Francesco Giuseppe, Foschi, Andrea, Casadei Gardini, Daniele, Nicolini, Susanna, Mazzocato, Kostandini, Alba, Paola, Violi, Umberto, Baccarani, Riccardo, Pravisani, Valter, Vincenzi, Guarino, Maria, Viganò, Luca, Ponziani, Francesca Romana, Giannini, Edoardo Giovanni, Lai, Quirino, Morisco, Filomena, Vitale, Alessandro, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Sessa, Anna, Villa, Erica, Rendina, Maria, Lupo, Luigi G., Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Cucchetti, Alessandro, Trevisani e Matteo Renzulli, Franco, Miele, Luca, Grieco, Antonio, Lodovico Rapaccini, Gian, Pompili, Maurizio, Gasbarrini, Antonio, Battisa Levi Sandri, Giovanni, Melandro, Fabio, Rossi, Massimo, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Sposito, Carlo, Bhoori, Sherrie, di Sandro, Stefano, Foschi, Francesco Giuseppe, Casadei Gardini, Andrea, Nicolini, Daniele, Mazzocato, Susanna, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, Vincenzi, Valter, CASADEI GARDINI, Andrea, Trevisani, Franco, and Matteo, Renzulli

Subjects
Oncology, Liver Cirrhosis, Cirrhosis, Sustained Virologic Response, DAA, HCC, HCV, Recurrence, medicine.disease_cause, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antiviral Agents, Carcinoma, Hepatocellular, Disease Progression, Hepatitis C, Chronic, Humans, Liver Neoplasms, Neoplasm Recurrence, Local, Neoplasm Staging, Risk Assessment, Chronic, Gastroenterology, hepatocellular carcinoma, Hepatitis C, Local, Hepatology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Risk assessment, Direct acting, Risk analysis, medicine.medical_specialty, Hepatitis C virus, DAA, HCC, HCV, Recurrence, 03 medical and health sciences, Internal medicine, medicine, Antiviral treatment, business.industry, Carcinoma, Hepatocellular, medicine.disease, Settore MED/18 - Chirurgia Generale, Neoplasm Recurrence, business
Abstract

Although studies suggest decreased incident hepatocellular carcinoma (HCC) after treatment with direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection, data are conflicting regarding risk and aggressiveness of recurrence in patients who have a history of treated HCC. This review analyses data available in literature in order to elucidate the impact of DAAs on the risk of HCC recurrence after successful treatment of the tumor. Overall 24 papers were identified. The available data cannot be considered definitive, but the initial alarmist data indicating an increased risk of recurrence have not been confirmed by most subsequent studies. The suggested aggressive pattern (rapid growth and vascular invasion) of tumor recurrence after DAAs still remains to be confirmed. Several limitations of the available studies were highlighted, and should drive future researches. The time-to-recurrence should be computed since the last HCC treatment and results stratified for cirrhosis and sustained viral response. Any comparison with historical series is of limited interest because of a number of biases affecting these studies and differences between enrolled patients. Prospective intention-to-treat analyses will be probably the best contribution to drive clinical practice, provided that a randomized trial can be difficult to design.

Published
2018

25. Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

Author

Guarino, Maria, Sessa, Anna, Cossiga, Valentina, Morando, Federica, Caporaso, Nicola, Morisco, Filomena, Luca, Viganó, Romana, Ponziani Francesca, Maurizio, Pompili, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Russo, FRANCESCO PAOLO, Vitale, Alessandro, Giuseppe, Cabibbo, Mauro, Vigano', Giovanni, Galati, Erica, Villa, Lupo, Luigi G., Maria, Rendina, Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Massimo, Iavarone, Brancaccio, Giuseppina, Cucchetti, Alessandro, Renzulli, Matteo, Franco, Trevisani, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Melandro, Fabio, Rossi, Massimo, Quirino, Lai, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Rodolfo, Sacco, Sposito, Carlo, Bhoori, Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, Vincenzi, Valter, Maria, Guarino, Anna, Sessa, Valentina, Cossiga, Federica, Morando, Nicola, Caporaso, Filomena, Morisco, Viganó, Luca, Ponziani Francesca, Romana, Pompili, Maurizio, Umberto, Cillo, Patrizia, Burra, Claudia, Mescoli, Martina, Gambato, Russo Francesco, Paolo, Vitale, Alessandro, Cabibbo, Giuseppe, Vigano', Mauro, Galati, Giovanni, Villa, Erica, Luigi G., Lupo, Rendina, Maria, Francesco, Losito, Fabio, Fucilli, Marcello, Persico, Roberta, D'Ambrosio, Angelo, Sangiovanni, Iavarone, Massimo, Brancaccio, Giuseppina, Alessandro, Cucchetti, Matteo, Renzulli, Trevisani, Franco, Luca, Miele, Antonio, Grieco, Gianlodovico, Rapaccini, Antonio, Gasbarrini, Giovanni Battisa Levi, Sandri, Fabio, Melandro, Massimo, Rossi, Lai, Quirino, Ilaria, Lenci, Tommaso Maria, Manzia, Raffaella, Tortora, Giovan Giuseppe, Di Costanzo, Davide, Ghinolfi, Erion, Rreka, Paola, Carrai, Natalia, Simonetti, Sacco, Rodolfo, Carlo, Sposito, Sherrie, Bhoori, Stefano, Di Sandro, Francesco Giuseppe, Foschi, Andrea Casadei, Gardini, Daniele, Nicolini, Susanna, Mazzocato, Kostandini, Alba, Paola, Violi, Umberto, Baccarani, Riccardo, Pravisani, Valter, Vincenzi, Guarino, Maria, Sessa, Anna, Cossiga, Valentina, Morando, Federica, Caporaso, Nicola, Morisco, Filomena, Luca, Viganó, Romana, Ponziani Francesca, Maurizio, Pompili, Cillo, Umberto, Burra, Patrizia, Mescoli, Claudia, Gambato, Martina, Paolo, Russo Francesco, Alessandro, Vitale, Giuseppe, Cabibbo, Mauro, Vigano', Giovanni, Galati, Erica, Villa, Lupo, Luigi G., Maria, Rendina, Losito, Francesco, Fucilli, Fabio, Persico, Marcello, D'Ambrosio, Roberta, Sangiovanni, Angelo, Massimo, Iavarone, Giuseppina, Brancaccio, Cucchetti, Alessandro, Renzulli, Matteo, Franco, Trevisani, Miele, Luca, Grieco, Antonio, Rapaccini, Gianlodovico, Gasbarrini, Antonio, Sandri, Giovanni Battisa Levi, Melandro, Fabio, Rossi, Massimo, Quirino, Lai, Lenci, Ilaria, Manzia, Tommaso Maria, Tortora, Raffaella, Di Costanzo, Giovan Giuseppe, Ghinolfi, Davide, Rreka, Erion, Carrai, Paola, Simonetti, Natalia, Rodolfo, Sacco, Sposito, Carlo, Bhoori, Sherrie, Di Sandro, Stefano, Foschi, Francesco Giuseppe, Gardini, Andrea Casadei, Nicolini, Daniele, Mazzocato, Susanna, Alba, Kostandini, Violi, Paola, Baccarani, Umberto, Pravisani, Riccardo, and Vincenzi, Valter

Subjects
Oncology, Cirrhosis, Direct-acting antiviral agent, Sustained Virologic Response, Direct-acting antiviral agents, Hepatitis C virus, Hepatocellular carcinoma, Occurrence, Recurrence, Antiviral Agents, Carcinoma, Hepatocellular, Disease Progression, Hepacivirus, Hepatitis C, Chronic, Humans, Incidence, Liver, Liver Neoplasms, Neoplasm Recurrence, Local, Risk Factors, Treatment Outcome, Gastroenterology, medicine.disease_cause, DIRECT ACTING ANTIVIRALS, 0302 clinical medicine, Chronic, biology, Incidence (epidemiology), Minireviews, General Medicine, Hepatitis C, Local, Liver Neoplasm, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Interferon therapy, 03 medical and health sciences, Chronic hepatitis, Internal medicine, medicine, Antiviral Agent, Hepaciviru, business.industry, Risk Factor, Carcinoma, Hepatocellular, medicine.disease, biology.organism_classification, digestive system diseases, Settore MED/18 - Chirurgia Generale, Neoplasm Recurrence, business, Hepatitis C viru
Abstract

With the introduction of direct-acting antiviral agents (DAA), the rate of sustained virological response (SVR) in the treatment of hepatitis C virus (HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma (HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4% (maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4% (maximum "not well-defined" followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection. © 2018 The Author(s). Published by Baishideng Publishing Group Inc. All rights reserved.

Published
2018

28. Tissue expression of Squamous Cellular Carcinoma Antigen (SCCA) is inversely correlated to tumor size in HCC

Author

Mangia Anita, Mazzocca Antonio, Lupo Luigi, Antonaci Giovanni, Angelotti Umberto, Fransvea Emilia, Trerotoli Paolo, Antonaci Salvatore, and Giannelli Gianluigi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background This study aimed to investigate squamous cellular carcinoma antigen (SCCA) in serum and in tumoral and paired peritumoral tissues. We studied 27 patients with liver cirrhosis (LC) and 55 with HCC: 20 with a single nodule < 3 cm (s-HCC) and 35 with a single nodule > 3 cm or multifocal (l-HCC). Methods Serum SCCA was measured by the ELISA kit, and in frozen tissues by immunohistochemistry, quantified with appropriate imaging analysis software and expressed in square microns. Continuous variables are reported as means and 95% confidence intervals. Comparisons between independent groups were performed with a generalized linear model and Tukey grouping. Pearson's correlation coefficients were determined to evaluate relations between markers. Qualitative variables were summarized as count and percentage. Statistical significance was set at p-value < 0.05. Results Serum SCCA values in LC patients were 0.41 (0.31–0.55) ng/ml and statistically different from both HCC groups: 1.6 (1.0–2.6) ng/ml in s-HCC, 2.2 (1.28–2.74) ng/ml in l-HCC. SCCA in hepatic tissue was 263.8 (176.6–394.01) μm2 in LC patients, statistically different from values in s-HCC: 1163.2 (863.6–1566.8) μm2 and l-HCC: 625.8 (534.5–732.6). All pairwise comparisons between groups yielded statistically significant differences. Tumoral SCCA resulted linearly related with nodule size, showing a statistically significant inverse relation between the two variables (b = -0.099, p = 0.024). Conclusion There was no statistically significant correlation between tissue and serum levels of SCCA. The significantly stronger expression of SCCA in smaller compared to larger HCC could be important for early HCC detection. However, the increased expression in peritumoral tissue could affect the significance of serological detection.

Published
2009
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29. Recurrence of hepatocellular carcinoma after direct acting antiviral treatment for hepatitis C virus infection: Literature review and risk analysis

Author

Guarino, Maria, primary, Viganò, Luca, additional, Ponziani, Francesca Romana, additional, Giannini, Edoardo Giovanni, additional, Lai, Quirino, additional, Morisco, Filomena, additional, Vitale, Alessandro, additional, Russo, Francesco Paolo, additional, Cillo, Umberto, additional, Burra, Patrizia, additional, Mescoli, Claudia, additional, Gambato, Martina, additional, Sessa, Anna, additional, Cabibbo, Giuseppe, additional, Viganò, Mauro, additional, Galati, Giovanni, additional, Villa, Erica, additional, Iavarone, Massimo, additional, Brancaccio, Giuseppina, additional, Rendina, Maria, additional, Lupo, Luigi G., additional, Losito, Francesco, additional, Fucilli, Fabio, additional, Persico, Marcello, additional, D’Ambrosio, Roberta, additional, Sangiovanni, Angelo, additional, Cucchetti, Alessandro, additional, Trevisani e Matteo Renzulli, Franco, additional, Miele, Luca, additional, Grieco, Antonio, additional, Lodovico Rapaccini, Gian, additional, Pompili, Maurizio, additional, Gasbarrini, Antonio, additional, Battista Levi Sandri, Giovanni, additional, Melandro, Fabio, additional, Rossi, Massimo, additional, Lenci, Ilaria, additional, Manzia, Tommaso Maria, additional, Tortora, Raffaella, additional, Di Costanzo, Giovan Giuseppe, additional, Sacco, Rodolfo, additional, Ghinolfi, Davide, additional, Rreka, Erion, additional, Carrai, Paola, additional, Simonetti, Natalia, additional, Sposito, Carlo, additional, Bhoori, Sherrie, additional, di Sandro, Stefano, additional, Foschi, Francesco Giuseppe, additional, Casadei Gardini, Andrea, additional, Nicolini, Daniele, additional, Mazzocato, Susanna, additional, Kostandini, Alba, additional, Violi, Paola, additional, Baccarani, Umberto, additional, Pravisani, Riccardo, additional, and Vincenzi, Valter, additional

Published
2018
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30. Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial

Author

Pinyol, Roser, primary, Montal, Robert, additional, Bassaganyas, Laia, additional, Sia, Daniela, additional, Takayama, Tadatoshi, additional, Chau, Gar-Yang, additional, Mazzaferro, Vincenzo, additional, Roayaie, Sasan, additional, Lee, Han Chu, additional, Kokudo, Norihiro, additional, Zhang, Zhongyang, additional, Torrecilla, Sara, additional, Moeini, Agrin, additional, Rodriguez-Carunchio, Leonardo, additional, Gane, Edward, additional, Verslype, Chris, additional, Croitoru, Adina Emilia, additional, Cillo, Umberto, additional, de la Mata, Manuel, additional, Lupo, Luigi, additional, Strasser, Simone, additional, Park, Joong-Won, additional, Camps, Jordi, additional, Solé, Manel, additional, Thung, Swan N, additional, Villanueva, Augusto, additional, Pena, Carol, additional, Meinhardt, Gerold, additional, Bruix, Jordi, additional, and Llovet, Josep M, additional

Published
2018
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32. Liver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registry

Author

Krawczyk, Marek, Grat, Michal, Adam, Rene, Polak, Wojciech G, Klempnauer, Jurgen, Pinna, Antonio, Di Benedetto, Fabrizio, Filipponi, Franco, Senninger, Norbert, Foss, Aksel, Rufián-Peña, Sebastian, Bennet, William, Pratschke, Johann, Paul, Andreas, Settmacher, Utz, Rossi, Giorgio, Salizzoni, Mauro, Fernandez-Selles, Carlos, Martínez de Rituerto, Santiago T, Gómez-Bravo, Miguel A, Pirenne, Jacques, Detry, Olivier, Majno, Pietro E, Nemec, Petr, Bechstein, Wolf O, Bartels, Michael, Nadalin, Silvio, Pruvot, Francois R, Mirza, Darius F, Lupo, Luigi, Colledan, Michele, Tisone, Giuseppe, Ringers, Jan, Daniel, Jorge, Charco Torra, Ramón, Moreno González, Enrique, Bañares Cañizares, Rafael, Cuervas-Mons Martinez, Valentin, San Juan Rodríguez, Fernando, Yilmaz, Sezai, Remiszewski, Piotr, Remiszweski, Piotr, Deschans, Bruno, Hans, Marie France, Meyer, Stephanie Hauss, Rutarova, Jana, Siems, Martina, Knochel, Cornelia Swillus, Wilhelm, Dietmar, Hecker, Sandy, Harms, Simone, Sakirow, Larissa, Eissing, Elvira, Schenk, Martin, Poli, Elisabetta, Guizzetti, Michela, Grazi, Gian Luca, Maggi, Umberto, Montalti, Roberto, Arenga, Giuseppe, Sforza, Daniele, Cibelli, Alessandra, Foss, Stein, Caetano, Rosario, Ispir, Mukadder, Krawczyk, M, Grat, M, Adam, R, Polak, W, Klempnauer, J, Pinna, A, Di Benedetto, F, Filipponi, F, Senninger, N, Foss, A, Rufian-Pena, S, Bennet, W, Pratschke, J, Paul, A, Settmacher, U, Rossi, G, Salizzoni, M, Fernandez-Selles, C, de Rituerto, S, Gomez-Bravo, M, Pirenne, J, Detry, O, Majno, P, Nemec, P, Bechstein, W, Bartels, M, Nadalin, S, Pruvot, F, Mirza, D, Lupo, L, Colledan, M, Tisone, G, Ringers, J, Daniel, J, Torra, R, Gonzalez, E, Canizares, R, Martinez, V, Rodriguez, F, Yilmaz, S, Remiszewski, P, and Surgery

Subjects
Registrie, Graft Rejection, Male, medicine.medical_specialty, medicine.medical_treatment, Medizin, 030230 surgery, Liver transplantation, Extracorporeal, Female, Humans, Injury Severity Score, Liver, Registries, Retrospective Studies, Liver Transplantation, 03 medical and health sciences, 0302 clinical medicine, Statistical significance, Risk of mortality, Medicine, Risk factor, Transplantation, ddc:617, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, Surgery, Settore MED/18, business, Human
Abstract

Background Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. Methods This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. Results Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk of mortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) on mortality (P = 0.071). The optimal cut-off for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. Conclusions Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process.

Published
2016

34. Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial.

Author

Pinyol, Roser, Montal, Robert, Bassaganyas, Laia, Sia, Daniela, Takayama, Tadatoshi, Gar-Yang Chau, Mazzaferro, Vincenzo, Roayaie, Sasan, Han Chu Lee, Kokudo, Norihiro, Zhongyang Zhang, Torrecilla, Sara, Moeini, Agrin, Rodriguez-Carunchio, Leonardo, Gane, Edward, Verslype, Chris, Croitoru, Adina Emilia, Cillo, Umberto, de la Mata, Manuel, and Lupo, Luigi

Subjects
SORAFENIB, THERAPEUTICS, STAT proteins, VASCULAR endothelial growth factor receptors, MET receptor
Published
2019
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36. Targeting Angiogenesis in Biliary Tract Cancers: An Open Option

Author

Simone, Valeria, primary, Brunetti, Oronzo, additional, Lupo, Luigi, additional, Testini, Mario, additional, Maiorano, Eugenio, additional, Simone, Michele, additional, Longo, Vito, additional, Rolfo, Christian, additional, Peeters, Marc, additional, Scarpa, Aldo, additional, Azzariti, Amalia, additional, Russo, Antonio, additional, Ribatti, Domenico, additional, and Silvestris, Nicola, additional

Published
2017
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37. Early introduction of subcutaneous hepatitis B immunoglobulin following liver transplantation for hepatitis B virus infection: A prospective, multicenter study

Author

De Simone, P, Romagnoli, R, Tandoi, F, Carrai, P, Ercolani, G, Peri, E, Zamboni, F, Mameli, L, Di Benedetto, F, Cillo, U, De Carlis, L, Lauterio, A, Lupo, L, Tisone, G, Prieto, M, Loinaz, C, Mas, A, Suddle, A, Mutimer, D, Roche, B, Wartenberg-Demand, A, Niemann, G, Böhm, H, Samuel, D, De Simone, Paolo, Romagnoli, Renato, Tandoi, Francesco, Carrai, Paola, Ercolani, Giorgio, Peri, Eugenia, Zamboni, Fausto, Mameli, Laura, Di Benedetto, Fabrizio, Cillo, Umberto, De Carlis, Luciano, Lauterio, Andrea, Lupo, Luigi, Tisone, Giuseppe, Prieto, Martin, Loinaz, Carmelo, Mas, Antoni, Suddle, Abid, Mutimer, David, Roche, Bruno, Wartenberg-Demand, Andrea, Niemann, Gabriele, Böhm, Heike, Samuel, Didier, De Simone, P, Romagnoli, R, Tandoi, F, Carrai, P, Ercolani, G, Peri, E, Zamboni, F, Mameli, L, Di Benedetto, F, Cillo, U, De Carlis, L, Lauterio, A, Lupo, L, Tisone, G, Prieto, M, Loinaz, C, Mas, A, Suddle, A, Mutimer, D, Roche, B, Wartenberg-Demand, A, Niemann, G, Böhm, H, Samuel, D, De Simone, Paolo, Romagnoli, Renato, Tandoi, Francesco, Carrai, Paola, Ercolani, Giorgio, Peri, Eugenia, Zamboni, Fausto, Mameli, Laura, Di Benedetto, Fabrizio, Cillo, Umberto, De Carlis, Luciano, Lauterio, Andrea, Lupo, Luigi, Tisone, Giuseppe, Prieto, Martin, Loinaz, Carmelo, Mas, Antoni, Suddle, Abid, Mutimer, David, Roche, Bruno, Wartenberg-Demand, Andrea, Niemann, Gabriele, Böhm, Heike, and Samuel, Didier

Abstract

Background. Subcutaneous administration of hepatitis B immunoglobulin (HBIg) is effective in preventing hepatitis B virus (HBV) recurrence after liver transplantation, but early conversion to subcutaneous administration is undocumented. Methods. In a prospective study, patients transplanted for terminal liver disease due to HBV infection who were HBV DNA-negative at transplant were switched by week 3 posttransplantation from intravenous to subcutaneous HBIg (500 or 1000 IU weekly or fortnightly, adjusted according to serumanti-HBs trough level) if they were HBsAg- and HBV-DNA negative at time of switch. All patients concomitantly received nucleos(t)ide analogue antiviral therapy. Primary endpoint was failure rate by month 6, defined as serum anti- HBs of 100 IU/L or less or HBV reinfection despite serum anti-HBs greater than 100 IU/L. Results. Of 49 patients treated, 47 (95.9%) continued treatment until month 6. All patients achieved administration by a caregiver or self-injection by week 14. No treatment failures occurred. Mean anti-HBs declined progressively to month 6, plateauing at a protective titer of approximately 290 IU/L. All patients tested for HBV DNA remained negative (45/45). Only 1 adverse event (mild injection site hematoma) was assessed as treatment-related. Conclusions. Introduction of subcutaneous HBIg administration by week 3 posttransplantation, combined with HBV virostatic prophylaxis, is effective and convenient for preventing HBV recurrence.

Published
2016

39. Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection

Author

De Simone, Paolo, primary, Romagnoli, Renato, additional, Tandoi, Francesco, additional, Carrai, Paola, additional, Ercolani, Giorgio, additional, Peri, Eugenia, additional, Zamboni, Fausto, additional, Mameli, Laura, additional, Di Benedetto, Fabrizio, additional, Cillo, Umberto, additional, De Carlis, Luciano, additional, Lauterio, Andrea, additional, Lupo, Luigi, additional, Tisone, Giuseppe, additional, Prieto, Martin, additional, Loinaz, Carmelo, additional, Mas, Antoni, additional, Suddle, Abid, additional, Mutimer, David, additional, Roche, Bruno, additional, Wartenberg-Demand, Andrea, additional, Niemann, Gabriele, additional, Böhm, Heike, additional, and Samuel, Didier, additional

Published
2016
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40. Balancing donor and recipient risk factors in liver transplantation: the value of D-MELD with particular reference to HCV patients

Author

Avolio, Alfonso Wolfango, Cillo, Umberto, Salizzoni, Mauro, De Carlis, Luciano, Colledan, Michele, Gerunda, Giorgio Enrico, Mazzaferro, Vincenzo, Tisone, Giuseppe, Romagnoli, Renato, Caccamo, Lucio, Rossi, Massimo, Vitale, Alessandro, Cucchetti, M, Lupo, Luigi, Gruttadauria, Salvatore, Nicolotti, Nicola, Burra, Patrizia, Gasbarrini, Antonio, and Agnes, Salvatore

Subjects
donor to recipient match, Liver transplantation, allocation, Settore MED/18 - CHIRURGIA GENERALE, HCV, outcome, risk factors, D-MELD, survival, MELD
Published
2011

41. OPTIMIZATION OF DONOR-RECIPIENT MATCH AND IDENTIFICATION OF THE FUTILE MATCH CUTOFF. A NATIONAL ITALIAN STUDY ON LIVER TRANSPLANTATION

Author

Avolio, Alfonso Wolfango, Agnes, Salvatore, Lirosi, Maria Carmen, Salizzoni, Mauro, Pinna, Antonio Daniele, Gridelli, Bruno, De Carlis, Luciano, Colledan, Michele, Gerunda, Giorgio Enrico, Valente, Umberto, Rossi, Giorgio, Ettorre, Giuseppe Maria, Risaliti, Andrea, Mazzaferro, Vincenzo, Bresadola, Francesco, Rossi, Massimo, Tisone, Giuseppe, Zamboni, Fausto, Lupo, Luigi, Cuomo, Oreste, Calise, Fulvio, Donataccio, Matteo, Nicolotti, Nicola, Vitale, Alessandro, Romagnoli, Renato, Lupo, Francesco, Cucchetti, Alessandro, Gruttadauria, Salvo, Mangoni, Iacopo, Pinelli, Domenico, Montalti, Roberto, Gelli, Massimiliano, Caccamo, Lucio, Vennarecci, Giovanni, Nicolini, Daniele, Regalia, Enzo, Baccarani, Umberto, Lai, Quirino, Manzia, Tommaso, Tondolo, Enzo, Rendina, Maria, Barone, Michele, Perrella, Alessandro, Romano, Maria, De Waure, Chiara, Burra, Patrizia, Gasbarrini, Antonio, Cillo, Umberto, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, and Cillo, U

Subjects
DONOR-RECIPIENT MATCH, Hepatology, Settore MED/18 - CHIRURGIA GENERALE, HCV, outcome, Gastroenterology, Donor recipient match, risk factors, Futile match, D-MELD, Liver Transplantation, MELD
Published
2011

42. Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel?

Author

Gnoni, Antonio, primary, Santini, Daniele, additional, Scartozzi, Mario, additional, Russo, Antonio, additional, Licchetta, Antonella, additional, Palmieri, Vincenzo, additional, Lupo, Luigi, additional, Faloppi, Luca, additional, Palasciano, Giuseppe, additional, Memeo, Vincenzo, additional, Angarano, Gioacchino, additional, Brunetti, Oronzo, additional, Guarini, Attilio, additional, Pisconti, Salvatore, additional, Lorusso, Vito, additional, and Silvestris, Nicola, additional

Published
2015
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50. Is Pyloric Function Preserved in Pylorus-preserving Pancreaticoduodenectomy?

Author

Lupo, Luigi G., Pannarale, Oronzo C., Altomare, Donato F., Caputi, Lucrezia, Dell'Erba, Laura, Ricci, Pasquale, and Memeo, Vincenzo

Subjects
*PANCREATICODUODENECTOMY, *PYLORUS
Abstract

Objective: To assess the function of the pylorus after pylorus-preserving pancreaticoduodenectomy (PPPD) done for periampullary or pancreatic cancer. Design: Prospective, observational controlled clinical study. Setting: Teaching hospital, Italy. Subjects: 17 patients who had undergone PPPD, and 15 healthy control subjects. Investigations: Endoscopy to check for gastritis and marginal ulcers and 24 h-pH monitoring and [sup 99m]Tc HIDA scintigraphy to detect jejunogastric reflux. Scintigraphy was also used to evaluate gastric and jejunal transit after a solid meal labelled with [sup 99m]Tc colloid sulphur. Main outcome measures: Signs of delayed gastric emptying, jejunogastric reflux and gastric outlet obstruction in the short and long term. Results: In the early postoperative period only 1 patient had delayed gastric emptying. In the long term, two patients had symptoms of dyspepsia and 8/11 showed alkaline reflux with persistent gastric pH more than 4 for more than 12 hours; 3 had histological signs of gastritis. There was no difference in gastric emptying compared with controls, but three patients had prolonged emptying time (T1/2 more than 85 minutes). Endoscopy findings correlated with pH monitoring results. Conclusions: After PPPD, most patients have abnormal pyloric function, but it is clinically evident in only a small proportion. [ABSTRACT FROM AUTHOR]

Published
1998
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