1. Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
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Emma Ruiz-Moreno, Adela Castelló, María Sierra, Marina Nieves Pino, Mercedes Martínez-Cortés, María José Toribio, María Dolores Luque de Castro, Feliciano Priego-Capote, Virginia Lope, Beatriz Pérez-Gómez, Nerea Fernández de Larrea-Baz, Marina Pollán, Pilar Lucas, [Toribio,MJ, Lope,V] Servicio de Admisión, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Toribio,MJ] Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain. [Priego-Capote,F, Luque de Castro,MD] Department of Analytical Chemistry, University of Córdoba, Córdoba, Spain. [Priego-Capote,F, Luque de Castro,MD] Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Pérez-Gómez,B, Fernández de Larrea-Baz,N, Ruiz-Moreno,E, Lucas,P, Sierra,MÁ, Lope,V, Pollán,M] Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. [Pérez-Gómez,B, Pollán,M] Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain. [Castelló,A] Faculty of Medicine, University of Alcalá, Alcalá de Henares, Spain. [Pino,MN, Martínez-Cortés,M] Servicio de Prevención y Promoción de la Salud, Madrid Salud, Ayuntamiento de Madrid, Madrid, Spain., This study was funded by the Spanish Ministry of Health (EC11–273) and by the Carlos III Institute of Health (PI15CIII/0029). The article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health., Ministerio de Sanidad (España), and Instituto de Salud Carlos III
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Metabolite ,Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholecalciferol::Hydroxycholecalciferols::Dihydroxycholecalciferols::24,25-Dihydroxyvitamin D 3 [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,chemistry.chemical_compound ,25(OH)D3 ,1,25(OH)2D3 ,TX341-641 ,Vit D3 ,Vitamin D ,Phenomena and Processes::Metabolic Phenomena::Metabolome [Medical Subject Headings] ,Nutrition and Dietetics ,Middle Aged ,vitamin D metabolite ratios ,Endogenous metabolism ,Clinical Practice ,24,25(OH)2D3 ,Metabolome ,Female ,Colecalciferol ,Adult ,medicine.medical_specialty ,Medical diagnostic ,Vitamina D ,chemistry.chemical_element ,24,25-Dihidroxivitamina D 3 ,Calcium ,Article ,Calcitriol ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Calcifediol ,Serum vitamin ,Nutrition. Foods and food supply ,business.industry ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Metabolism ,Vitamin D metabolite ratios ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Sexual Development::Climacteric::Menopause::Premenopause [Medical Subject Headings] ,Endocrinology ,chemistry ,Check Tags::Female [Medical Subject Headings] ,Premenopause ,business ,Food Science - Abstract
The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes. This study was funded by the Spanish Ministry of Health (EC11–273) and by the Carlos III Institute of Health (PI15CIII/0029). The article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health. Sí
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- 2021
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