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Shu-Hui Lv,1– 3,* Wang-Zhong Li,1,2,* Hu Liang,1,2 Guo-Ying Liu,1,2 Wei-Xiong Xia,1,2 Yan-Qun Xiang1,2 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China; 2Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, China; 3Medical Affairs Office, The Fifth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan-Qun Xiang; Wei-Xiong XiaDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, ChinaTel\Fax +86-1866-6096-623 Email xiangyq@sysucc.org.cn; xiawx@sysucc.org.cnPurpose: We sought to assess the prognostic and predictive value of a circulating inflammation signature (CISIG) and develop CISIG-based tools for predicting prognosis and guiding individualized induction chemotherapy (ICT) in non-metastatic nasopharyngeal carcinoma (NPC).Patients and Methods: We retrospectively collected a candidate inflammatory biomarker panel from patients with NPC treated with definitive radiotherapy between 2012 and 2017. We developed the CISIG using candidate biomarkers identified by a least absolute shrinkage and selection operator (LASSO) Cox regression model. The Cox regression analyses were used to evaluate the CISIG prognostic value. A CISIG-based prediction model was constructed, validated, and assessed. Potential stratified ICT treatment effects were examined.Results: A total of 1149 patients were analyzed. Nine biomarkers selected by LASSO regression in the training cohort were used to construct the CISIG, including hyaluronidase, laminin, procollagen III, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, high-density lipoprotein, lactate dehydrogenase, and C-reactive protein-to-albumin ratio. CISIG was an independent prognostic factor for disease-free survival (DFS; hazard ratio: 2.65, 95% confidence interval: 1.93– 3.64; P < 0.001). High CISIG group (>− 0.2) was associated with worse 3-year DFS than low CISIG group in both the training (67.5% vs 88.3%, P < 0.001) and validation cohorts (72.3% vs 85.1%, P < 0.001). We constructed and validated a CISIG-based nomogram, which showed better performance than the clinical stage and Epstein–Barr virus DNA classification methods. A significant interaction between CISIG and the ICT treatment effect was observed (P for interaction = 0.036). Patients with high CISIG values did not benefit from ICT, whereas patients with low CISIG values significantly benefited from ICT.Conclusion: The developed CISIG, based on a circulating inflammatory biomarker panel, adds prognostic information for patients with NPC. The proposed CISIG-based tools offer individualized risk estimation to facilitate suitable ICT candidate identification.Keywords: nasopharyngeal carcinoma, inflammatory biomarkers, circulating inflammation signature, prognostic value, predictive value, induction chemotherapy

Wang-Zhong Li,1,2,* Xin Hua,3,* Shu-Hui Lv,1,2,* Hu Liang,1,2 Guo-Ying Liu,1,2 Nian Lu,1,2 Wei-Xin Bei,1,2 Wei-Xiong Xia,1,2 Yan-Qun Xiang1,2 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan-Qun Xiang; Wei-Xiong XiaDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of ChinaTel +86-1866-6096-623Email xiangyq@sysucc.org.cn; xiawx@sysucc.org.cnPurpose: We aimed to develop a simple scoring system based on baseline inflammatory and nutritional parameters to predict the efficacy of first-line chemotherapy and survival outcomes for de novo metastatic nasopharyngeal carcinoma (mNPC).Patients and Methods: We retrospectively collected ten candidate inflammatory and nutritional parameters from de novo mNPC patients who received platinum-based first-line chemotherapy treatment. We examined the effects of these ten candidate variables on progression-free survival (PFS) using the Cox regression model. We built a risk-scoring system based on the regression coefficients associated with the identified independent prognostic factors. The predictive accuracy of the scoring system was evaluated and independently validated.Results: A total of 460 patients were analyzed. Four independent prognostic factors were identified in a training cohort and were used to construct the scoring system, including nutritional risk index, C-reactive protein level, alkaline phosphatase level, and lactate dehydrogenase level. Based on the score obtained from the scoring system, we stratified patients into three prognostic subgroups (low: 0– 1 point, intermediate: 2– 3 points, and high: 4 points) associated with significantly different disease control rates (94.7% vs. 92.5% vs. 66.0%, respectively) and survival outcomes (3-year PFS: 55.8% vs. 29.1% vs. 11.9%, respectively). The scoring system had a good performance for the prediction of short-term disease control (area under the receiver operating characteristic curve [AUC]: 0.701) and long-term survival outcomes (time-dependent AUC for 5-year PFS: 0.713). The results were internally validated using an independent cohort (AUC for predicting disease control: 0.697; time-dependent AUC for 5-year PFS: 0.713).Conclusion: We developed and validated a clinically useful risk-scoring system that could predict the efficacy of first-line chemotherapy and survival outcomes in de novo mNPC patients. This system may help clinicians to design personalized treatment strategies.Keywords: metastatic nasopharyngeal carcinoma, nutritional status, cancer-related inflammation, chemotherapy efficacy, survival outcomes

Abstract This study was performed to analyze fingertip capillary blood sampling in pediatric patients using microcapillary blood collection tubes and microhematocrit tubes and to compare the blood cell analysis results obtained via these two blood collection methods. Finger capillary blood was collected from 110 outpatients using microcapillary blood collection tubes and microhematocrit tubes and complete blood count analysis was performed with a Sysmex XS-900i hematology analyzer and manual microscopy for blood cell morphology. Paired data was evaluated for agreement and bias using the microhematocrit samples as the reference group and the samples from the microcapillary blood collection tubes as the observation group. The two blood collection methods demonstrated good agreement for measuring red blood cell (RBC) parameters (i.e., RBC, Hb, Hct, MCV, MCH and MCHC), wherein the relative bias was > allowable total error (TEa) in 0.91%, 1.82%, 11.82%, 1.82%, 0.91% and 8.18% of the parameter measures, respectively. According to industry requirements, the proportion of samples meeting the acceptable bias level should be > 80%. Additionally, the estimated biases at each medical decision level were within clinically acceptable levels for RBC, Hb, Hct, and MCV. However, the proportion of WBC and PLT counts with relative bias > TEa was 25.45% and 35.45%, respectively. Furthermore, the relative bias of the WBC count at the medical decision level of 0.5 × 109/L and that of the PLT counts at the medical decision levels of 10 × 109/L and 50 × 109/L were clinically significant. Bland–Altman analysis further showed a mean bias of 0.66 × 109/L (95% LoA, − 0.79 to 2.11) for the WBC count and 39 × 109/L (95% LoA, − 46 to 124) for the PLT count from the blood samples collected in the microcapillary blood collection tubes compared with the counts of those collected in the microhematocrit tubes. Neutrophil, monocyte, lymphocyte, eosinophil, and PLT counts increased significantly in the microcapillary blood collection tubes compared with those in the microhematocrit tubes, along with an elevated number of instrument false alarms (P

To explore the effect of AFN on knee function and complications in patients after TKA.

This study targets at asymmetric deformation of narrow coal pillar in gob-side entry driving.We put forward the bidirectional reinforcement of narrow pillar with opposite-crossing anchor cable.Specifically, we designed two types of anchor cable structure: the byelongation type and the expansion lock type, and carried out the pull-out test of opposite-crossing anchor cable, the test shows that both anchor cable structures could meet the tensile requirements.We conducted comparative analysis on the morphology of anchor cable failure, construction convenience and the economic aspect of material selection, where the expansion lock type crossed anchor was selected for narrow coal pillar bidirectional reinforcement.Furthermore, we investigated the bearing deformation patterns of coal pillars and the stress characteristics of anchor cables under different reinforcement methods through similar model tests and numerical simulation.Results show a 96.04% increase of peak load in the specimen reinforced by the double-row tight opposite-crossing anchor cable compared with that of the not reinforced specimen, and higher stability of the narrow pillar reinforced by the double-row tight opposite-crossing anchor cable as the rows of the anchor cable increases in number.The expansion lock anchor type crossed cable improved the energy storage and the critical failure point before the coal pillar was destroyed.Finally, the engineering test of expansive lock type crossed anchor cable to reinforcing narrow coal pillar was carried out in the transportation roadway of 123 lower 04 working face of Jining No.3 Coal Mine.The monitoring show that the anchoring force of the anchor cable exceeded 220kN, with 70& reduction of the coal pillar in the reinforcement area and good overall stability of the narrow coal pillar.It proves the feasibility of the bidirectional reinforcement technology of narrow pillar and provides new technical way for gob-side entry driving.

Objective To explore the photodynamic treatment method and therapeutic effect of oral verrucous carcinoma and to provide a reference for the clinic. Methods This study follows the requirements of medical ethics. This paper summarized the photodynamic treatment of an oral verrucous carcinoma with a diameter of approximately 2.5 cm in the right buccal mucosa and retrospectively analyzed the characteristics and treatment of oral verrucous carcinoma and the photodynamic treatment of potential malignant lesions of the oral mucosa through a review of the literature. Results After four rounds of photodynamic therapy, the size of the right buccal lesion was significantly reduced. After 6 months of follow-up, the white verrucous hyperplasia of the right buccal mucosa had completely subsided, and there was no obvious scar formation. Three years after treatment, there was no recurrence of the lesion in the right buccal mucosa and no obvious scar formation in the treated area. The degree of mouth opening was 3 fingers, and there was no lymph node enlargement in the bilateral submandibular, submental or neck. The literature review shows that oral verrucous carcinoma is a rare subtype of squamous cell carcinoma with the characteristics and biological behaviors of slow growth, low malignancy, and rare metastasis. Surgery is the preferred treatment, but there are some limitations. Photodynamic therapy is a minimally invasive, repeatable treatment with mild adverse reactions. In recent years, photodynamic therapy has been gradually applied for the treatment of potential malignant disorders of the oral mucosa and early oral squamous cell carcinoma and has achieved positive results, but it has not been reported for the treatment of oral verrucous cancer. Conclusion Photodynamic therapy is a new option for nonsurgical resection of oral verrucous carcinoma.

BackgroundThis study investigates the burden of chronic kidney disease attributed to type 2 diabetes (CKD-T2D) across different geographical locations and time periods from 1990 to 2019. A total of 204 countries and regions are included in the analysis, with consideration given to their socio-demographic indexes (SDI). The aim is to examine both spatial and temporal variations in CKD-T2D burden.MethodsThis research utilized data from the 2019 Global Burden of Diseases Study to evaluate the age-standardized incidence rates (ASIR), Disability-Adjusted Life Years (DALYs), and Estimated Annual Percentage Change (EAPC) associated with CKD-T2D.ResultsSince 1990, there has been a noticeable increase of CKD age-standardized rates due to T2D, with an EAPCs of 0.65 (95% confidence interval [CI]: 0.63 to 0.66) for ASIR and an EAPC of 0.92 (95% CI: 0.8 to 1.05) for age-standardized DALYs rate. Among these regions, Andean Latin America showed a significant increase in CKD-T2D incidence [EAPC: 2.23 (95% CI: 2.11 to 2.34) and North America showed a significant increase in CKD-T2D DALYs [EAPC: 2.73 (95% CI: 2.39 to 3.07)]. The burden was higher in male and increased across all age groups, peaking at 60-79 years. Furthermore, there was a clear correlation between SDI and age-standardized rates, with regions categorized as middle SDI and High SDI experiencing a significant rise in burden.ConclusionThe global burden of CKD-T2D has significantly risen since 1990, especially among males aged 60-79 years and in regions with middle SDI. It is imperative to implement strategic interventions to effectively address this escalating health challenge.

Air purifier use, shift work, and long-term exposure to fine particulate matter (PM2.5) are linked to platelet abnormality. However, the role of air purifier use and shift work in the individual or joint associations of PM2.5 and its components with platelet indices are largely unknown. A total of 8772 participants were recruited from a population of subway workers in China. PM2.5 and its component data were obtained from the Tracking Air Pollution in China dataset. The role of air purifier use and shift work in the association between PM2.5 and its components and platelet indices were analyzed. Among shift workers without air purifier use, positive associations of PM2.5 and each component in PM2.5 with the mean platelet volume (MPV) or platelet counts (PLT) were observed, whereas negative associations of PM2.5 and each component in PM2.5 with the platelet distribution width (PDW) were observed. Furthermore, estimated changes (95%CIs) in PLT, MPV, and PDW in response to each 10th percentile increment in the mixture of PM2.5 and its components were 0.8657 (0.2496, 1.4819), 0.0192 (0.0054, 0.0329), and −0.0648 (−0.0945, −0.0351), respectively, and sulfate in PM2.5 was the major contributor to those associations. Long-term exposure to PM2.5 and its components was related to increased platelet disorders among shift workers without air purifier use, and those associations were mainly attributed to sulfate in PM2.5.

Neuropathy in surgical-related locations has received concerns after total hip arthroplasty (THA), while the contralateral intercostal nerve (ICN) injury has not been reported. A 25-year-old female patient with a body mass index (BMI) of 17.9 kg/m2 visited the orthopedic outpatient clinic with complaints of progressive left hip pain for 20 days. She was diagnosed with left end-stage hip osteoarthritis and developmental dysplasia of the bilateral hips after radiographs and a detailed history-taking. After painstaking consideration, a cementless THA with the standard posterolateral approach was performed under general anesthesia. The procedure was difficult but successful. Unexpectedly, the numbness and slight tingling in the skin of the right breast, lateral chest wall, and axilla cropped up on the first postoperative day. Following the clinical features and the conclusion of the multidisciplinary discussion, we assume that ICN neuropathy is the diagnosis in this case due to compression of the lateral decubitus position during the operation. Her symptoms completely disappeared after using mecobalamin injection (0.5 mg, intramuscular injection, every other day) for 11 days. The Harris left hip score improved from 39 to 94, and the visual analogue scale from 7 was reduced to 2 on the day of discharge. There were no other complications within the first year after the operation. For THA, we should pay attention to some unexpected complications by virtue of the special position, especially in thin and low-BMI people, which suggested that further comprehensive perioperative nursing measures and the beneficial surgical position and anesthesia type were called for.

The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

Abstract Background Primary gastrointestinal natural killer (NK)/T‐cell lymphoma (PGINKTL) is a rare T‐/NK‐cell lymphoma subtype, and the clinical features and survival outcomes remain largely unknown. Methods To summarize the clinical features and survival outcomes of PGINKTL, PGINKTL cases diagnosed at our hospital from May 1999 to December 2020 were reviewed; and the clinical data, information on treatment strategies, and survival were collected. Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional hazards regression. We constructed a nomogram to visualize the survival prediction of PGINKTL. The discriminative ability and calibration of the nomogram for prediction were tested using the concordance index (C‐index) and calibration plots. Results The cohort included 81 cases, the median age was 36 years (range, 7–80 years), and the male‐to‐female ratio was 1.7:1. The most common clinical symptom at the time of diagnosis was abdominal pain (71.6%). The most common lesion site was the colon (59.3%). During a median follow‐up period of 37.7 months, the median overall survival (OS) time of 81 patients was 4.0 months (95% confidence interval [CI], 3.1–4.9 months), and the 2‐year OS rate was 30.7% (95% CI, 20.3%–40.1%). The multivariate analyses indicated that patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score ≥2, serum lactic dehydrogenase (LDH) level ≥ the upper limit normal (ULN), and perforation had worse OS. We used these data to establish a nomogram to predict survival for PGINKTL. The nomogram displayed good accuracy, with a C‐index of 0.726. Conclusion The clinical features and poor outcomes of PGINKTL, which is a rare and fatal lymphoma type, are presented. The proposed nomogram provides an individualized estimate of survival for these patients. In the future, the study focused on exploring a better treatment strategy to improve survival is required in PGINKTL.

Thomassen described all (except finitely many) regular tilings of the torus S1 and the Klein bottle N2 into (3,6)-tilings, (4,4)-tilings and (6,3)-tilings. Many researchers made great e orts to investigate the crossing number of the Cartesian product of an m-cycle and an n-cycle, which is a special kind of (4,4)-tilings, either in the plane or in the projective plane. In this paper we study the crossing number of the hexagonal graph H3,n (n ≥ 2), which is a special kind of (3,6)-tilings, in the projective plane, and prove that crN1(H3,n)={0,n=2,n-1,n≥3.cr{N_1}\left( {{H_{3,n}}} \right) = \left\{ {\matrix{{0,} \hfill & {n = 2,} \hfill \cr {n - 1,} \hfill & {n \ge 3.} \hfill \cr } } \right.

The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer's disease. In this study, an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices. The plasma pharmacokinetics, tissue distribution, and excretion of sodium oligomannate in Sprague-Dawley rats and beagle dogs were systematically investigated. Despite its complicated structural composition, the absorption, distribution, metabolism, and excretion profiles of the oligosaccharides in sodium oligomannate of different sizes and terminal derivatives were indiscriminate. Sodium oligomannate mainly crossed the gastrointestinal epithelium through paracellular transport following oral administration, with very low oral bioavailability in rats (0.6%–1.6%) and dogs (4.5%–9.3%). Absorbed sodium oligomannate mainly resided in circulating body fluids in free form with minimal distribution into erythrocytes and major tissues. Sodium oligomannate could penetrate the blood-cerebrospinal fluid (CSF) barrier of rats, showing a constant area under the concentration-time curve ratio (CSF/plasma) of approximately 5%. The cumulative urinary excretion of sodium oligomannate was commensurate with its oral bioavailability, supporting that excretion was predominantly renal, whereas no obvious biliary secretion was observed following a single oral dose to bile duct-cannulated rats. Moreover, only 33.7% (male) and 26.3% (female) of the oral dose were recovered in the rat excreta within 96 h following a single oral administration, suggesting that the intestinal flora may have ingested a portion of unabsorbed sodium oligomannate as a nutrient.

BACKGROUND Multi-target geochemical mapping is one of the most important basic regional tasks in multi-target regional geochemical surveys. In order to better reflect changes in the geochemical background, analytical methods are required to have higher accuracy and precision, and lower detection limits. Elements B, Ge, Br, Mo, Sn, I, and W in geochemical survey samples are mainly prepared and determined by smelting ore individually or in groups. The analysis procedure is long and involves 6 methods. OBJECTIVES In order to integrate 6 supporting analysis methods, optimize analysis conditions, and improve the accuracy and precision of the method. METHODS The mixed reagent of sodium peroxide and sodium hydroxide was used for alkali fusion. Citric acid was added to the solution. Cation exchange resin was used for static exchange for 2-3 hours to remove a large amount of cations in the solution and reduce matrix interference. B, Ge, Br, Mo, Sn, I, and W were determined using inductively coupled plasma mass spectrometry. RESULTS The detection limits of B, Ge, Br, Mo, Sn, I, and W were 0.66, 0.096, 0.78, 0.11, 0.15, 0.29, and 0.27μg/g, respectively. Relative standard deviation (RSD, n=12) was between 2.1% and 7.5%, which were all less than 10%. CONCLUSIONS The method is simple, rapid and low-cost, and its precision and accuracy meet the requirements of 《Specification of multi-purpose regional geochemical survey (1:250000)》 (DZ/T 0258-2014). It can quickly and accurately determine B, Ge, Br, Mo, Sn, I, W in geochemical survey samples in a thick coverage area.

ObjectiveTo establish a detection method for 9 yellow colorants in fish tissues by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).MethodsSample was extracted by ammonia methanol solution and formic acid water methanol solution, the supernatant was evaporated and redissolved, the fat was removed by n-hexane, determinated by UPLC-MS/MS method after centrifugation, and quantification was based on external calibration.ResultsThe result showed good linearity in the ranges of 2-30 μg/kg for tartrazine, sunset yellow and quinoline yellow, 0.2-3.0 μg/kg for acid orange Ⅱ, basic orange 2, basic orange 21, basic orange 22, thioflavin T and auramine O, and the limits of detection were 2 μg/kg and 0.2 μg/kg. The recoveries were 80.03%-107.06% and the relative standard deviations(n=6)were 1.2%-6.6%.ConclusionThe method can be applied to determine 9 yellow colorants in fish tissues.

In this paper, an attempt is made to describe the method that combines the results obtained from nanoindentation experiment with finite element simulation to determine or establish the elastic-plastic properties of a super-hydrophobic anti-icing coating. The nanoindentation test was conducted and elastic properties of the coating, to include elastic modulus and hardness were obtained. The plastic properties, to include yield stress, monotonic strength coefficient and monotonic strain hardening exponent, were obtained using an inverse, iterative method of experimental measurement in synergism with finite element simulation. This approach, which is a combination of experimental data obtained from the nanoindentation test and results obtained from numerical finite element simulation, was found to be effective for determining mechanical properties of the chosen coating.

Abstract Most human pathogens originate from non-human hosts and certain pathogens persist in animal reservoirs. The transmission of such pathogens to humans may lead to self-sustaining chains of transmission. These pathogens represent the highest risk for future pandemics. For their prevention, the transmission over the species barrier — although rare — should, by all means, be avoided. In the current COVID-19 pandemic, surprisingly though, most of the current research concentrates on the control by drugs and vaccines, while comparatively little scientific inquiry focuses on future prevention. Already in 2012, the World Bank recommended to engage in a systemic One Health approach for zoonoses control, considering integrated surveillance-response and control of human and animal diseases for primarily economic reasons. First examples, like integrated West Nile virus surveillance in mosquitos, wild birds, horses and humans in Italy show evidence of financial savings from a closer cooperation of human and animal health sectors. Provided a zoonotic origin can be ascertained for the COVID-19 pandemic, integrated wildlife, domestic animal and humans disease surveillance-response may contribute to prevent future outbreaks. In conclusion, the earlier a zoonotic pathogen can be detected in the environment, in wildlife or in domestic animals; and the better human, animal and environmental surveillance communicate with each other to prevent an outbreak, the lower are the cumulative costs.

A fatty acid value determination method in grain was developed by using automatic photometric titrator with KOH as standard titration solution in this paper, in which magnetic stirring apparatus was selected as extraction device, anhydrous ethanol was used as extraction solvent, and thymol blue was used to control directing terminal. Finally, the fatty acid value was calculated by combining the consumed volume of KOH's standard titration solution. The instrument can automatically complete the whole process of extraction, filtration,quantitative transfer, titration and calculation. The results showed that the determination method has high precision, and the repeatability, accuracy and stability can meet the requirements of the national standard method, the consistency between instruments can meet the repeatability requirement of national standard method, the measuring time of paddy and wheat flour were one-third and one-half respectively of those by potentiometric or manual titration, and the measuring time of maize was two-fifths of the potentiometric titration and one-half of the manual titration. With a wide application range, the method was easy to operateand less to be disturbed by human factors, it is very suitable for batch and rapid determination of fatty acid value in grain. In a word, this method provided a suitable method for strict quality control in the grass-roots grain storage companies when purchasing grain and detection of large quantities fatty acid value in grain inspection agency.

Buformin has been reported to be a powerful anticancer drug by activating the AMPK signal. Herein, we aimed to investigate the effects of buformin on osteosarcoma.

The adjudication process is a central part of the overall personal rights injunction process. The procedure for adjudication of personality injunctions includes the commencement of personality injunction proceedings, the jurisdiction of the case, the manner of hearing, the content of the hearing and the standard of review, as well as the making of the ruling on the personality injunction, and other specific elements. Among them, the clarification of the application conditions and examination criteria for injunction is pivotal to the correct application of personality injunction. The current legal provisions are relatively homogeneous and far from meeting the needs of judicial decisions. Therefore, this article will focus on the conditions to be met in order to initiate a personality injunction and the factors to be taken into account by the court in granting a personality injunction.

Experiments of a steel sphere oblique impact with a rubber cushion have been proceeded to research the variation laws of the specific energy at interface. The contact surfaces above and under the rubber cushion can be recorded with a thin carbon paper. The parameters of deformation volume and specific energy are analyzed by the developed formulas in different cases of the impact angle, cushion thickness, drop height and sphere diameter. It is found that the deformation volume and related geometrical sizes decrease approximately exponentially with the impact angle, and the volume of the tangential moving part reaches a maximum at 50° or 60°. The variation laws of the specific energy absorption/dissipation in normal are similar to that of the axis length. The tangential specific energy can be divided into three main phases, the first two appear the states of slow increase and plateau, between of them a fluctuating peak exists at 30–40°. In final phase, the energy absorption shows sharp increase, but the energy dissipation first increases and then decreases. In addition, they increase linearly with the drop height and sphere diameter, and an optimum cushion thickness of 4 or 5 mm in the given cases.

To explore potential functional biomarkers in diabetes mellitus (DM) by utilizing gene pathway cross-talk.

In order to discuss opening and cavity shear flow-induced vibration and structural coupling resonance, experiments of opening and cavity shear flow-induced vibration and structural noise control are carried out. The impact of the opening size, flow velocity and cavity thickness on shear oscillation noise, self-noise in the cavity and radiated noise are analyzed. The results show that the empirical formula of the opening shear oscillation in air is also applicable to the condition underwater, which the shear oscillation and amplitude of modal frequencies are directly proportional to the flow velocity; in case that no coupling resonance occurs, the thickness of the cavity wall will bring slight influence on the amplitude of the shear oscillation, but not on the mode frequencies; also the coupling of shear oscillatory mode and cavity wall mode show dramatic coupling resonance under certain conditions, and leads to self-noise and acoustic radiation. The findings supply useful exploration and technical support concerning the application of opening and cavity structural noise control measures.

Rice wine is a kind of low alcohol and high nutrition four season drinking wine made from water and glutinous rice. Generally, new rice wine needs to undergo a natural aging process for about 1 year. In order to solve the problems of long natural aging period and poor aging effect of rice wine, a set of rice wine aging device was designed and a comprehensive method was used to age the rice wine. By orthogonal experiments, the optimal aging process parameters were determined, which were temperature 55 °C, aging time 12 days, and hydrogen peroxide addition 4 mL/200 mL. The results show that the content of ethyl acetate and ethyl lactate in rice wine are 0.44 g/L and 0.80 g/L respectively and the content of total acid and total sugar reaches 6.9 g/L and 230.2 g/L respectively. Compared with naturally aged rice wine, it is verified that the effect of artificial aging can achieve the effect of natural aging for one year. This experiment provides a new method for the study of artificial aging of rice wine.

With the reform of chemical transportation industry accelerating, the safety evaluation of chemical transportation industry in China is becoming more and more standardized. Based on the theory of big data analysis and SPSS software as a platform, first of all, of the Beijing 91 the system construction and management of dangerous chemicals transportation enterprises, safety culture, safety production standardization 24 safety evaluation indexes such as principal component analysis, it is concluded that safety training basic requirements, loading and unloading operation, parking lot, civil air defense, vehicle dynamic supervision, system construction and management, safety production standardization, pilot eight kinds of factors as the main indexes for safety assessment. After using the eight indexes of 91 clustering analysis for transport enterprises, the enterprise is divided into five clusters of reasonable results, through the summary of common characteristics within the same cluster enterprises, it is concluded that the handling operation index plays an important role in classification for transport enterprises such as conclusion, can provide reference for other areas. At the same time, the conclusion can be used as a reference for the follow-up safety evaluation of hazardous chemical transportation enterprises, so as to achieve the purpose of targeted safety inspection.

A fine aerosol particle pollution episode happened in mega city Beijing during February 25th – March 5th. Aerosol extinction coefficient profiles were observed at 7 L idar s ta ti ons. Different aerosol optical property instruments were used to verify Lidar retrievals. Ground visibility observations were used to verify near ground Lidar observations. High correlation coefficient was found (0.8) between visiometer and Lidar observations. Lidar’s Column integrated aerosol extinction coefficient was also verified by Himawari-8 aerosol optical depth (AOD) data. The correlation coefficient between two AOD retrievals was 0.4. And the mean bias was -0.17. CALIPSO aerosol property profiles was also used to verify Lidar retrievals. Lidar retrievals was inconsistent with CALIPSO in the boundary layer. Overall, the Lidar retrievals are consistent with other optical property sensors. And the retrials could be used for observation research and model validation.

In this paper, bubbles are generated by controlling the air inlet volume of the ceramic tube array with a gas divider valve. Stimulation tests of sound attenuation characteristics of the wake of bubbles in a laboratory pool are performed. A measurement experiment of sound attenuation coefficient was carried out in the case of still water and bubbles with different particle sizes. The signal frequency is 20-200kHz. Through experimental research, it is found that the existence of bubbles makes the sound attenuation coefficient significantly larger. And the attenuation coefficient is related to the frequency of the sound waves and the size of the bubbles. At the same frequency, the larger the bubble size , the larger the attenuation coefficient will be. When the bubble size is constant, the attenuation of the acoustic signal in small bubbles will change greatly below 50kHz. Above 50kHz, the attenuation coefficient changes relatively smoothly and the fluctuation is small. In the case of medium and large bubbles, the fluctuation of the attenuation coefficient becomes larger than that in the small bubbles. Finally, the theoretically calculated sound attenuation coefficient is compared with the experimentally measured results. And the change trends of the two results are basically the same.

High permeability and strength magnesium phosphate cement (MPC) with porosity, average pore size, and compressive strength varied from 63.2% to 74%, 138.7 μm to 284.7 μm and 2.3 MPa to 4.7 MPa, respectively, were successfully prepared by combining the physical foaming method and chemically entrained gas method at room temperature. The effects of borax content, chemical foaming agent content, zinc powder content and W/S ratio on the porosity, pore size distribution, compressive strength, and permeability of the MPC were investigated. The results indicate that the chemical foaming agent content tends to have little impact on the porosity and compressive strength, and the zinc powder content has the most significant influence on the average pore size of MPC. The air pores distribution and connectivity of MPC were mainly controlled by the borax content, W/S ratio, and chemical foaming agent content. Zinc powder played a destructive role in the pores formed by the early physical foaming and led to an increase in pore size and a large number of through pores, which increased the permeability of the materials.

The Tuosibasitao Fe-Cu-Au mineral deposit mainly occurs in the contact zone between the diorite porphyrite and basaltic volcanic rock of Middle Devonian Beitashan Formation in the forms of massives, heterogeneous gobbets, veinlets, breccia and veinlet-disseminated. The ore bodies in the ore deposit occur as stratoids or lenses, surrounded by skarn. The major and trace elements in magnetite, and chemical components in garnet, chinopyoxene and epidote from Tuosibasitao deposit were studied by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Electron microprobe analyse. The results demonstrate that the end member of garnet is mainly grossularite and andradite. The composition of pyroxene was mainly diopside, with a small amount of augite. The epidote was enriched in Fe and Ca. The composition of these skarn minerals suggest that skarn in Tuosibasitao ore deposit is calcic skarn. In combination with the geological characteristics, it is possible that the skarns are formed by hydrothermal interaction with metamorphic volcanic, and the formation of magnetite is related to the retrogressive metamorphism of the skarn. Copper and gold mineralization occurred during the quartz-sulphide- carbonate period.

The Liangkeshu iron deposit in Xinjiang is located in the Kelang basin at the southern margin of Altay. The iron deposit occurs in pegmatite dikes at the contact zone of monzonitic granite and schist of the Middle-Upper Devonian Aletai Formation. Fluid inclusions in quartz from the ore body, which are mainly liquid inclusions were studied by micro temperature measurement and are described in this paper. The results indicate that the homogenization temperatures of the fluid inclusions varied from 156℃ to 367℃, mostly distributed from 210℃ to 250℃. The salinity (NaCleq) of fluids ranged from 0.18% to 18.72% and the densities ranged from 0.80 g/cm3 to 0.95 g/cm3. Ore fluids in the Liangkeshu iron deposit were characterized by medium temperature, low salinity and low density, and belonged to the H2O-NaCl system. δDSMOW values of quartz were from -110‰ to -76‰, δ18OSMOW values changed from 5.3‰ to 7.9‰ and δ18OH2O values varied from 1.03‰ to 1.07‰, implying that the ore-forming fluid was magmatic water mixed with meteoric water. Fe mineralization in the Liangkeshu deposit occurred in the Middle Devonian period (about 377 Ma), and is closely related to the monzonitic granite. The decrease of temperature and pressure, the fluids mixing and water-rock reaction played important roles in ore-forming processes of the Fe ore bodies.

In order to improve stability of environment monitoring system and save system's resource, the paper proposed a design scheme of environment monitoring system composed by lower computer, transmission network and upper computer. It introduced design of hardware and software of the lower computer in the system in details. The hardware of the lower computer takes ARM9 processor S3C2410 as core, its software uses multi-thread application program to process multi-task at the same time and uses semaphore and mutex to realize synchronization among threads. The actual application showed that the system runs stably and improves system efficiency.

The structure of Microbial Fuel Cell (MFC) reactor was analyzed and improved by Reverse Engineering (RE) and Rapid Prototyping (RP) technology. Points cloud data of MFC reactor was accessed by hand-held laser scanner. The space surface and entity model were reconstructed accurately, and the structure of the reactor was optimized based on Imageware and Solidworks software. The reactor model was manufactured by RP machine. The optimization efficiency of MFC reactor was improved based on the combination of RE and RP, which has a good reference value for the development of MFC technology and products.

In the solar photovoltaic power station project, PV support is one of the main structures, and fixed photovoltaic PV support is one of the most commonly used stents. For the the actual demand in a Japanese photovoltaic power, SAP2000 finite element analysis software is used in this paper, based on Japanese Industrial Standard (JIS C 8955-2011), describing the system of fixed photovoltaic support structure design and calculation method and process. The results show that: (1) according to the general requirements of 4 rows and 5 columns fixed photovoltaic support, the typical permanent load of the PV support is 4679.4 N, the wind load being 1.05 kN/m2, the snow load being 0.89 kN/m2 and the seismic load is 5877.51 N; (2) by theoretical calculation of the two ends extended beam model, the beam span under the rail is determined 2200 mm; (3) by the way of using the single factor experiment, through the calculation and analysis of SAP2000, the three best supporting points of the support of the W stent are determined; (4) by comprehensive simulation, the optimal parameters for the rail, beam, support and bolt are 60× 60× 1.0, 60× 60× 1.0, 40× 50× 2.0, and M10 respectively.

In order to improve the mechanical properties of the polymer materials, three kinds of samples with the same size were manufactured by the 3D printing equipment. And the materials were polycarbonate, ABS and polypropylene, respectively. After -190°C+8h cryogenic treatment, the mechanical properties such as wear resistance and hardness were tested and the functional groups and internal molecule chain changes were observed by Fourier transform infrard spectrometer. The results showed that the mechanical properties of polymer materials can be improved effectively after the cryogenic treatment. Compared with the untreated samples, the hardness of the PC, ABS and PP samples increased by 27.6%, 10.8% and 20.3% respectively. Among the three materials, the wear resistance of ABS material was improved obviously.

In this paper, finite element simulation (FES) of the effect of free vibration treatment on fatigue damage recovery for notched copper film with the thickness of 33 um was investigated. The damage process analyzed by static analysis of original specimen and vibration process analyzed by transient dynamic analysis of damaged specimen were simulated respectively. The transient dynamic analysis was conducted with different frequencies and acceleration amplitudes. It is found that the plastic strain was produced as a result of cyclic loading and reduced after the vibration treatment. The values of plastic strain are different after treatment with different vibration frequencies and acceleration amplitudes. Furthermore, the plastic strain in notch reduces more than that of other areas of the specimen. According to the analysis, the vibration treatment can reduce the plastic strain of notched specimen significantly by which the microproperties are improved so that fatigue damage can be recovered.

Aiming at the problem of the method that demands a high accuracy of the equipment with a high price and low generality in measuring the elastic modulus by using the direct method, a device and a method are proposed to measure the elastic modulus of the rod-shaped object based on image processing. The image of the rod-shaped object is gotten using the proposed measurement device. The coordinates of the point on the contour line and the centroid of the cross-section of the rod-shaped object are extracted by using the object image with loading and no-loading respectively. The elastic modulus is computed by using the deflection difference formula. Finally an example is given to verify the feasibility and effectiveness of the device and method that lay a solid foundation for future study of the rod-shaped object elastic modulus measurement.

The traditional image restoration methods of interactive entertainment are based on the original data. This paper proposes an interactive entertainment image restoration method based on Hopfield neural network. Firstly, the nonlinear mapping relationship between the degraded image and the real image is preliminarily established through the network, and then optimized by the algorithm. Finally, the image restoration can be achieved through the network. The experiments show that it has higher feasibility and the recovery effect on small-scale blur is better than the existing method.

On the basis of the complete mappings concept, this paper gives difference value characteristics between image and inverse image of random permutation. Through giving lower bound of the number of some same difference value between image and inverse image, it is proved that RSA encryption function is not a complete mappings. At the same time, a conceive of attack to RSA digital signature scheme is given based on non-complete mappings characteristics of RSA.

Word sense disambiguation (WSD) is a challenging natural language processing (NLP) problem. We propose a new strategy for WSD, which at first replaces the interesting word in a sentence by the different synonyms corresponding to the different meanings, and then justify whether the transformed sentence is “legal”. A legal sentence is still legal after one or more word are replaced by other ones with the same meaning. A long short-term memory (LSTM) network-based model is proposed to perform the sentence/text classification. Furthermore, we build a Chinese WSD dataset based on HIT-CIR Tongyici Cilin (Extended) dataset. The model is evaluated on the new dataset and achieves better performance than the state-of-the-art.

Hybrid electric bus has a number of advantages when compared with ordinary passenger cars, but in the dynamic matching and the vehicle performance are difficult to detect, thus limits its development process. In this paper, combined with the actual models, the hybrid electric bus module parameters were modified in the software of ADVISOR (Advanced Vehicle Simulator), main including: module of the vehicle, the wheel module, motor module, a battery module and engine module, three kinds of bus models for A, B and C were established, and the related performance that need to be analyzed was set up, such as acceleration, gradability, emissions and energy utilization and so on, in order to ensure the vehicle running in the same environment and convenient for comparison, a fixed vehicle driving cycles was chose, then the simulation results was analyzed, and the various performance was compared with the dynamic indicators and economic indicators which determined by referencing of traditional city bus standard and each other, and finally, the performance optimal model of B was chose out which can meet the demand, its related performance parameters of the simulation results are as follows: the best gradability is 26%, maximum speed is 72.7km/h, maximum acceleration is 1.7m/s2, 0~50km/h acceleration time is 9.5s and fuel consumption is 25L/km.

OBJECTIVE: To determine whether intestinal epithelial cells have a receptor for intestinal trefoil factor and characterize receptor-ligand binding kinetics. METHODS: Radioligand binding assays were performed to characterize the binding kinetics between [(125)I]-labeled ITF and IEC-6, HT-29, Caco2 and HaCaT cells. The K d, Bmax and other kinetic variables describing the interaction between ITF and its potential receptors were determined. RESULTS: Radioligand binding assays performed at 4 °C showed that the K d value for the association between [(125)I]-ITF and IEC-6, HT-29, and Caco2 cells were 1.99 ± 0.12 × 10(-9) M, 3.89 ± 0.42 × 10(-9) M, and 2.04 ± 0.17 × 10(-9) M, respectively. Bmax values were 1.17 ± 0.04 × 10(11), 3.97 ± 0.29 × 10(11), and 2.03 ± 0.08 × 10(11) sites/cell, respectively. The K i values for the interaction between IEC-6, HT-29, and Caco2 cells and non-labeled ITF were 20.98 ± 0.57 nM, 36.87 ± 3.35 nM, and 21.38 ± 0.93 nM, respectively, and the IC50 values were 25.21 ± 0.39 nM, 40.68 ± 0.27 nM, and 23.61 ± 0.25 nM, respectively. Radioligand binding kinetic results showed the association rate constants (k +1) for IEC-6, HT-29, and Caco2 cells were 0.22 ± 0.04 min(-1), 0.29 ± 0.04 min(-1), and 0.26 ± 0.05 min(-1), respectively, and the dissociation rate constants (k -1) were 0.06 ± 0.02 min(-1), 0.03 ± 0.01 min(-1), and 0.04 ± 0.01 min(-1), respectively. For the HaCaT cells, the K d was 4.86 ± 0.28 × 10(-8) M and B max was 5.81 ± 0.15 × 10(8) sites/cell, the very low specific binding between [(125)I]-ITF and these cells made it impossible to calculate binding kinetic parameters. CONCLUSIONS: An ITF-specific receptor appears to be present on the three types of intestinal epithelial cells (IEC-6, HT-29, and Caco-2), and there may be no ITF receptor on epidermal cells.

Based on spatial finite element analysis method, the Influence of pavement on fatigue performance of orthotropic steel deck was analyzed in terms of pavement system, asphalt pavement stiffness. The result shows that compared with asphalt pavement system, RPC pavement system can not only obviously improve the stress condition of steel bridge deck, but also significantly extend the fatigue life of steel bridge panel; Increasing the stiffness of pavement layer can obviously reduce the stress amplitude of fatigue details, especially for direct contact with the pavement.

A novel circularly polarized antenna with polarization reconfigurable characteristics was designed using co-simulation of Ansoft HFSS and Designer software. It consists of a dual-polarized antenna and phase switching network which act as the feed network for the dual-polarized antenna. The phase switching network was designed based on a Wilkinson power divider, where the output port was connected with SPDT to form a switching network. By controlling the SPDT state-off / on, the phase difference of the two ports could be alternated, which generated the orthogonal modes between the two ports of dual-polarized antenna. So that Left-hand circular polarization (LHCP) and Right-hand circular polarization (RHCP) could be achieved. The simulation shown that reflection coefficient was less than -12 dB and the axial ratio was below 3 dB between 1.8 GHz and 2.4 GHz with polarization reconfigurable characteristics.

Abstract Background Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. Method In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. Results Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. Conclusions The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.