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Your search keyword '"Lyakhova, Ekaterina G."' showing total 27 results
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27 results on '"Lyakhova, Ekaterina G."'

1. Rhabdastrellosides A and B: Two New Isomalabaricane Glycosides from the Marine Sponge Rhabdastrella globostellata, and Their Cytotoxic and Cytoprotective Effects

Author

Kozhushnaya, Anastasia B., primary, Kolesnikova, Sophia A., additional, Yurchenko, Ekaterina A., additional, Lyakhova, Ekaterina G., additional, Menshov, Alexander S., additional, Kalinovsky, Anatoly I., additional, Popov, Roman S., additional, Dmitrenok, Pavel S., additional, and Ivanchina, Natalia V., additional

Published
2023
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11. Lissodendoric Acids A and B, Manzamine-Related Alkaloids from the Far Eastern Sponge Lissodendoryx florida

Author

Lyakhova, Ekaterina G., primary, Kolesnikova, Sophia A., additional, Kalinovsky, Anatoly I., additional, Berdyshev, Dmitrii V., additional, Pislyagin, Evgeny A., additional, Kuzmich, Aleksandra S., additional, Popov, Roman S., additional, Dmitrenok, Pavel S., additional, Makarieva, Tatyana N., additional, and Stonik, Valentin A., additional

Published
2017
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12. Cyclobutastellettolides A and B, C19Norterpenoids from a Stellettasp. Marine Sponge

Author

Kolesnikova, Sophia A., Lyakhova, Ekaterina G., Kalinovsky, Anatoly I., Berdyshev, Dmitrii V., Pislyagin, Evgeny A., Popov, Roman S., Grebnev, Boris B., Makarieva, Tatyana N., Minh, Chau Van, and Stonik, Valentin A.

Abstract

Two novel C19terpenoids (1, 2) with an unprecedented carbon skeleton (A) were isolated from a Stellettasp. sponge collected from Vietnamese waters. Their structures and absolute configurations were established by extensive NMR, MS, and ECD analyses together with quantum chemical modeling and biogenetic considerations. The probable pathways of biogenesis of 1and 2from isomalabaricane triterpenoids are discussed. Compounds 1and 2significantly increase the production of reactive oxygen species in murine peritoneal macrophages.

Published
2019
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13. Guaiane Sesquiterpenoids from the Gorgonian Menella woodin

Author

Lyakhova, Ekaterina G., primary, Diep, Chau Ngoc, additional, Berdyshev, Dmitrii V., additional, Kolesnikova, Sophia A., additional, Kalinovsky, Anatoly L, additional, Dmitrenok, Pavel S., additional, Tu, Vu Anh, additional, Cuong, Nguyen Xuan, additional, Van Thanh, Nguyen, additional, Nam, Nguyen Hoai, additional, Van Kiem, Phan, additional, Stonik, Valentin A., additional, and Van Minh, Chau, additional

Published
2016
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24. Isolation, Structures, and Biological Activities of Triterpenoids from a Penaressp. Marine Sponge

Author

Kolesnikova, Sophia A., Lyakhova, Ekaterina G., Kalinovsky, Anatoly I., Pushilin, Michail A., Afiyatullov, Shamil Sh., Yurchenko, Ekaterina A., Dyshlovoy, Sergey A., Minh, Chau V., and Stonik, Valentin A.

Abstract

Six new triterpenoids (1–6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penaressp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Configurations of the triterpene epoxy lactones (1–4) were determined on the basis of NOESY and CD data and calculation of spin coupling constants and confirmed by X-ray crystallographic analysis of compound 2. The isolated triterpenoid 6was cytotoxic against human leukemia HL-60 cells (IC50= 9.7 μM).

Published
2013
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25. Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease.

Author

Kolesnikova, Sophia A., Lyakhova, Ekaterina G., Kalinovsky, Anatoly I., Popov, Roman S., Yurchenko, Ekaterina A., and Stonik, Valentin A.

Abstract

Four new oxysterols 1–4 along with previously known oxygenated sterols 5–14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1–4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1–14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated. [ABSTRACT FROM AUTHOR]

Published
2018
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27. Cyclobutastellettolides A and B, C 19 Norterpenoids from a Stelletta sp. Marine Sponge.

Author

Kolesnikova SA, Lyakhova EG, Kalinovsky AI, Berdyshev DV, Pislyagin EA, Popov RS, Grebnev BB, Makarieva TN, Minh CV, and Stonik VA

Subjects
Animals, Macrophages, Peritoneal drug effects, Macrophages, Peritoneal metabolism, Mice, Molecular Structure, Porifera metabolism, Reactive Oxygen Species metabolism, Porifera chemistry, Terpenes chemistry, Terpenes pharmacology
Abstract

Two novel C 19 terpenoids ( 1 , 2 ) with an unprecedented carbon skeleton ( A ) were isolated from a Stelletta sp. sponge collected from Vietnamese waters. Their structures and absolute configurations were established by extensive NMR, MS, and ECD analyses together with quantum chemical modeling and biogenetic considerations. The probable pathways of biogenesis of 1 and 2 from isomalabaricane triterpenoids are discussed. Compounds 1 and 2 significantly increase the production of reactive oxygen species in murine peritoneal macrophages.

Published
2019
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