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1. SPLENECTOMIA, METODĂ TERAPEUTICĂ ÎN ABORDAREA PACIENTULUI DIAGNOSTICAT CU LIMFOM MALIGN DE ZONĂ MARGINALĂ.

Author

Nica, Adriana Elena, Vlădăreanu, Ana-Maria, and Oprescu, Sorin Mircea

Abstract

Marginal zone malignant lymphoma is a non-Hodgkin lymphoma, with B-cell proliferation, with indolent evolution, representing about 5-17% of all non-Hodgkin malignancies in adult patients. Etiologically, there is a constant association with chronic infections, but also with inflammation; in this case, chronic immune antigenic stimulation results in a lymphoid increase, from which the further oncological events occur, involving chromosomal abnormalities that activate intracellular signaling pathways, leading to antigen independent lymphoproliferation. The MALT subtype is the most common form of marginal zone non-Hodgkin lymphoma; in 50-70% of cases there is also an association with autoimmune disorders such as Hashimoto's thyroiditis, Wegener's granulomatosis, Sjögren's syndrome, and systemic lupus erythematosus. For diagnostic certainty of this type of lymphocytes, is required histopathological examination of spleen after surgical splenectomy or morphological/immunophenotype examination of circulating lymphocytes if there splenic lymphoma with villous lymphocytes. [ABSTRACT FROM AUTHOR]

Published
2016

2. Alterações hematológicas e hemostasia na COVID-19: uma revisão de literatura

Author

Pereira, Ana Flávia, Terra, Ana Karolina Aparecida, Oliveira, Carlos Henrique Santos, Terra, Michele Caroline, Oliveira, Carla Miguel de, Carvalho, Layla Pereira de, Oliveira, Sofia de Castro, Rotondo, Kamila Oliveira de Luca, Botelho, Letícia Mendonça, Oliveira , Camila dos Santos, Camilo, Felipe Fidelis, Delmoro, Ana Carolina Lima, and Salles, Bruno Cesar Correa

Subjects
Platelets, Vírus da SARS, Plaquetas, Linfocitos, COVID-19, Blood count, SARS virus, Índices de eritrocitos, Virus del SARS, Lymphocites, Índices de Eritrócitos, Conteo de glóbulos, Linfócitos, Hemograma, Erythrocyte Indices
Abstract

The COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which belongs to the new strain of the coronavirus, identified in China in early December 2019. This one presents symptoms and serious conditions, which can lead to Severe Acute Respiratory Syndrome. Thus, the need for a laboratory hematological profile of SARS-CoV-2 infection and its monitoring, becomes of great value to assist in the prognosis and treatment of the disease. This systematic review aims to trace the hematological profile resulting from infection by the SARS-CoV-2 virus, identifying the main changes found in the leukogram, erythrogram and platelet chart. For the elaboration of this study, an electronic search was carried out in several databases. The most frequently found hematological changes were lymphopenia, leukopenia, neutrophilia associated with leukocytosis, eosinopenia, reduced hemoglobin, thrombocytopenia and platelet aggregation, in addition to morphological changes. Anemia was not noticeably observed, but the reduction in hemoglobin was evident in healthy patients. The coagulation factors associated with platelet reduction as well as its hyper activation were altered in critically ill patients. These changes demonstrate the state of hypercoagulability present in critically ill patients with COVID-19, present in microthrombus pictures in various organs, being one of the most serious complications of COVID-19. Therefore, platelet count and changes in parameters associated with platelets are currently a concern. However, with the survey carried out, it is evident that an inflammation associated with high oxidative damage will compromise the hemostasis and leukocyte physiology of patients with COVID-19. COVID-19 es una enfermedad infecciosa causada por el virus SARS-CoV-2, que pertenece a la nueva cepa de coronavirus, identificada en China a principios de diciembre de 2019. Esta infección presenta síntomas leves y severos, que pueden derivar en Síndrome Respiratorio Agudo Grave. Por lo tanto, la necesidad de un perfil hematológico de laboratorio de la infección por SARS-CoV-2 y su seguimiento, se vuelve de gran valor para ayudar en el pronóstico y tratamiento de la enfermedad. Esta revisión sistemática tiene como objetivo rastrear el perfil hematológico resultante de la infección por el virus SARS-CoV-2, identificando los principales cambios encontrados en el leucograma, eritrograma y tabla de plaquetas. Para la elaboración de este estudio se realizó una búsqueda electrónica en varias bases de datos. Los cambios hematológicos más frecuentemente encontrados fueron linfopenia, leucopenia, neutrofilia asociada a leucocitosis, eosinopenia, hemoglobina reducida, trombocitopenia y agregación plaquetaria, además de cambios morfológicos. La anemia no se observó de forma notable, pero la reducción de la hemoglobina fue evidente en los pacientes sanos. Los factores de coagulación asociados con la reducción de plaquetas así como su hiperactivación se alteraron en pacientes críticamente enfermos. Estos cambios demuestran el estado de hipercoagulabilidad presente en pacientes críticamente enfermos con COVID-19, resultando en imágenes de microtrombos en varios órganos, que es una de las complicaciones más graves del COVID-19. Por lo tanto, el recuento de plaquetas y los cambios en los parámetros asociados con las plaquetas son actualmente una preocupación. Sin embargo, con la encuesta realizada, es evidente que la inflamación asociada a un alto daño oxidativo comprometerá la hemostasia y la fisiología leucocitaria de los pacientes con COVID-19. A COVID-19 é uma doença infecciosa causada pelo vírus SARS-CoV-2, o qual pertence à nova cepa do coronavírus, identificado na China no início de dezembro de 2019. Essa infecção apresenta sintomas leves e graves, podendo levar à Síndrome Respiratória Aguda Grave. Dessa forma, a necessidade de um perfil hematológico laboratorial da infecção pelo SARS-CoV-2 e seu monitoramento, torna-se de grande valia para auxiliar no prognóstico e tratamento da doença. Esta revisão sistemática tem como objetivo traçar o perfil hematológico decorrente da infecção pelo vírus SARS-CoV-2, identificando as principais alterações encontradas no leucograma, eritrograma e plaquetograma. Para a elaboração deste estudo foi realizada uma busca eletrônica em diversos bancos de dados. As alterações hematológicas mais frequentemente encontradas foram linfopenia, leucopenia, neutrofilia associada à leucocitose, eosinopenia, redução de hemoglobina, trombocitopenia e agregação plaquetária, além das alterações morfológicas. A anemia não foi observada de forma notável, mas a redução da hemoglobina foi evidente em relação a pacientes saudáveis. Os fatores de coagulação associados à redução de plaquetas assim como a sua hiper ativação foram alterados em pacientes graves. Essas alterações demonstram o estado de hipercoagulabilidade presente em pacientes graves com COVID-19, resultando em quadros de microtrombos em vários órgãos, sendo esta uma das complicações mais graves da COVID-19. Sendo assim, a contagem de plaquetas e as alterações dos parâmetros associados às plaquetas são atualmente uma preocupação. Contudo, com o levantamento realizado, fica evidente que a inflamação associada a um dano oxidativo elevado irá comprometer a hemostasia e fisiologia leucocitária de pacientes com COVID-19.

Published
2021

3. The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists*.

Author

Bullón, Pedro, Machuca, Guillermo, Armas, José R., Rojas, José L., and Jiménez, Gema

Subjects
*HEART diseases, *THERAPEUTICS, *PERIODONTITIS, *CALCIUM antagonists, *DRUG side effects, *DISEASE risk factors
Abstract

Abstract Objectives: To analyse the periodontal inflammatory infiltrates in patients with cardiac disease, some of these patients were treated with calcium antagonists (nifedipine and diltiazem) and some were not, to compare them with a healthy control group, and to evaluate the changes in the inflammatory infiltrate after periodontal treatment. Material and methods: A “healthy group” (HG, n=12), a “cardiac group” (CG, n=12) without treatment with calcium antagonists, a “nifedipine group” (NG, n=18) and a “diltiazem group” (DG, n=13) were analysed. Biopsies were taken from a zone 2–3 mm below the upper part of the interproximal papillae 12–13 and 33–32 before causal periodontal treatment and after 1 year. Using haematoxylin-eosin staining, the plasma cells (P), lymphocytes (L), histiocytes (H) and polymorphonuclear cells (PMN) were counted. T and B lymphocytes were evaluated using the monoclonal antibodies anti-CD20 and anti-CD45RO. Statistical tests used: χ2 for study of the sample composition; ANOVA for comparison between groups; Student t-test and Wilcoxon test for comparison between visits; post-hoc test Bonferroni. Results: When the cells were compared statistically, differences were stablished for L at the first visit (p<0.00001) and at the last visit (p<0.02), for the B lymphocytes (first visit p<0.0021, last visit p<0.022) and for the T lymphocytes (first visit p<0.0042, last visit p<0.0021). Between the 2 visits, HG showed significant reductions for P (p<0.01), L (p<0.045) and H (p<0.033); and the NG for L (p<0.0001). Lymphocytes showed differences in the NG with respect to the B lymphocytes (p<0.008). Conclusions: Nifedipine affects the inflammatory infiltrate with a greater number of lymphocytes (especially B) and these cells fell significantly in number after periodontal treatment. [ABSTRACT FROM AUTHOR]

Published
2001
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4. Immunophenotyping of lymphocytes in healthy and immunodeficient children

Author

Vries, E. (Esther) de and Vries, E. (Esther) de

Abstract

This thesis describes the use of immunophenotyping of lymphocytes in healthy as well as immunodeficient children. Part I describes the applied techniques (Chapters 2 and 3). The experimental work in healthy children is described in Part II (Chapters 4-7) and Part III describes the experimental work in immunodeficient children (Chapters 8-13). A summary and discussion of the work is given in Part IV.

Published
1999

6. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study

Author

Babio, N. (Nancy)

Subjects
Metabolic disorders, White blood cells, Cholesterol, Obesity, Lymphocites
Abstract

BACKGROUND: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS. METHODS: Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components. RESULTS: Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend

Published
2013

7. Apport de l'immunologie a la compréhension de l'histopathologie des tests épicutanés allergiques

Author

Achten, Georges and Achten, Georges

Abstract

The histological aspect of allergic epicutaneous tests assumes dramatic importance if it is analyzed in the light of experimental immunological findings. These shows the important function of the activated lymphocyte which secretes chemical amboceptors or lymphokins. These lymphokins are responsible for the disposition of the elements which produce the histological image observed under the photonic or electronic microscope. The vascular permeability factor dilates the capillaries; the chemotactic factor draws the cells of the infiltrate to it; the factor inhibiting macrophage migration prevents the cells leaving the site of the reaction; the mitogenetic factor draws to itself the normal lymphocytes and ensures that some of them are transformed into lymphoblasts; the cytotoxicity of the activated lymphocytes results in changes in the epidermic cell. The presence of the macrophage is essential for the liberation of these chemical amboceptors. © 1973 Expansion Scientifique Française., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
1973

9. White blood cell counts as risk markers of developing metabolic syndrome and its components in the Predimed study

Author

Jaime Algorta, Marta Guasch-Ferré, Itziar Salaverría Lete, Josep Basora, Mònica Bulló, Rosa Casas, Estefania Toledo, Miguel A. Martinez-Gonzalez, ITZIAR ZAZPE, Julia Warnberg, Andrés Díaz-López, Francisco M Martín Luján, José V Sorlí, José Manuel Santos Lozano, Lluis Serra-Majem, Jordi Salas-Salvadó, NANCY BABIO SÁNCHEZ, Manuel Ortega-Calvo, Inmaculada Bautista-Castaño, Almudena Sanchez Villegas, Joan D. Fernandez-Ballart, PREDIMER Study Investigators, [Babio,N, Ibarrola-Jurado,N, Bulló,M, Salas-Salvadó,J] Human Nutrition Unit, Sant Joan Hospital, IISPV, Universitat Rovira i Virgili, Reus, Spain. [Babio,N, Ortega-Calvo,M, Estruch,R, Salas-Salvadó,J] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Reus, Spain. [Martínez-González,MA] Department of Preventive Medicine and Public Health, Medical School-Clínica, University of Navarra, Pamplona, Spain. [Wärnberg,J] Department of Preventive Medicine, University of Málaga, Málaga, Spain. [Salaverría,I] Department of Cardiology, University Hospital Txagorritxu, Vitoria, Spain. Department of Family Medicine, Primary Care Division of Sevilla, Esperanza Macarena Health Center, Sevilla, Spain. [Estruch,R] Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Serra-Majem,LL] Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain. [Covas,MI] Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research (IMIM), Barcelona, Spain. [Sorli,JV] Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain. CIBER Fisiopatología de la Obesidad y Nutricion, Valencia, Spain., This study was funded, in part, by the Spanish Ministry of Health (ISCIII), PI1001407, Thematic Network G03/140, RD06/0045, FEDER (Fondo Europeo de Desarrollo Regional), and the Centre Català de la Nutrició de l'Institut d'Estudis Catalans. None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. CIBERobn is an initiative of ISCIII, Spain., Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili., and Universitat de Barcelona

Subjects
Male, Síndrome metabòlica, Mediterranean diet, Neutrophils, Epidemiology, Estudios transversales, Metabolic disorders, Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Disease, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Diet, Mediterranean, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Leukocyte Count, Lymphocites, Risk Factors, Blood plasma, Pathology, Medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, Metabolic Syndrome, Clinical Chemistry, Multidisciplinary, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean [Medical Subject Headings], Middle Aged, Metabolic syndrome, Clinical Laboratory Sciences, 1932-6203, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], medicine.anatomical_structure, Cholesterol, Cardiovascular diseases, Cardiovascular Diseases, White blood cells, Female, Public Health, Enfermedades cardiovasculares, Research Article, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Recuento de linfocitos, Science, Check Tags::Male [Medical Subject Headings], Mediterranean cooking, Diagnostic Medicine, Internal medicine, White blood cell, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count::Lymphocyte Count [Medical Subject Headings], Cuina mediterrània, Humans, Lymphocyte Count, Obesity, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Cardiovascular Disease Epidemiology, Aged, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings], business.industry, Malalties cardiovasculars, Recuento de leucocitos, Síndrome X metabólico, medicine.disease, Long-Term Care, Dieta mediterránea, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count [Medical Subject Headings], Biomarker Epidemiology, Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Geriatrics, Immunology, Clinical Immunology, Preventive Medicine, Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils [Medical Subject Headings], business, Dyslipidemia, Biomarkers, General Pathology
Abstract

Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; TRIAL REGISTRATION Controlled-Trials.comISRCTN35739639. BACKGROUND The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS. METHODS Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components. RESULTS Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend

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