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9 results on '"Lynch, Anthony Simon"'

1. Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections

Author

Buckley, Peter T., Chan, Rita, Fernandez, Jeffrey, Luo, Jinquan, Lacey, Keenan A., DuMont, Ashley L., O’Malley, Aidan, Brezski, Randall J., Zheng, Songmao, Malia, Thomas, Whitaker, Brian, Zwolak, Adam, Payne, Angela, Clark, Desmond, Sigg, Martin, Lacy, Eilyn R., Kornilova, Anna, Kwok, Debra, McCarthy, Steve, Wu, Bingyuan, Morrow, Brian, Nemeth-Seay, Jennifer, Petley, Ted, Wu, Sam, Strohl, William R., Lynch, Anthony Simon, and Torres, Victor J.

Published
2023
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2. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens

Author

Ma, Zhenkun, primary, He, Shijie, additional, Yuan, Ying, additional, Zhuang, Zhijun, additional, Liu, Yu, additional, Wang, Huan, additional, Chen, Jing, additional, Xu, Xiangyi, additional, Ding, Charles, additional, Molodtsov, Vadim, additional, Lin, Wei, additional, Robertson, Gregory T., additional, Weiss, William J., additional, Pulse, Mark, additional, Nguyen, Phung, additional, Duncan, Leonard, additional, Doyle, Timothy, additional, Ebright, Richard H., additional, and Lynch, Anthony Simon, additional

Published
2022
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3. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice

Author

Lubkin, Ashira, Lee, Warren L., Alonzo, Francis, 3rd, Wang, Changsen, Aligo, Jason, Keller, Matthew, Girgis, Natasha M., Reyes-Robles, Tamara, Chan, Rita, O’Malley, Aidan, Buckley, Peter, Vozhilla, Nikollaq, Vasquez, Marilyn T., Su, Johnny, Sugiyama, Michael, Yeung, Stephen T., Coffre, Maryaline, Bajwa, Sofia, Chen, Eric, Martin, Patricia, Kim, Sang Y., Loomis, Cynthia, Worthen, G. Scott, Shopsin, Bo, Khanna, Kamal M., Weinstock, Daniel, Lynch, Anthony Simon, Koralov, Sergei B., Loke, P'ng, Cadwell, Ken, and Torres, Victor J.

Published
2019
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4. Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria

Author

Zhuang, Zhijun, primary, Wan, Dawei, additional, Ding, Jun, additional, He, Shijie, additional, Zhang, Qian, additional, Wang, Xiaomei, additional, Yuan, Ying, additional, Lu, Yu, additional, Z. Ding, Charles, additional, Lynch, Anthony Simon, additional, M. Upton, Anna, additional, B. Cooper, Christopher, additional, A. Denny, William, additional, and Ma, Zhenkun, additional

Published
2020
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6. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.

Author

Zhenkun Ma, Shijie He, Ying Yuan, Zhijun Zhuang, Yu Liu, Huan Wang, Jing Chen, Xiangyi Xu, Charles Ding, Molodtsov, Vadim, Wei Lin, Robertson, Gregory T., Weiss, William J., Pulse, Mark, Phung Nguyen, Duncan, Leonard, Doyle, Timothy, Ebright, Richard H., and Lynch, Anthony Simon

Published
2022
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7. Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus

Author

Chan, Rita, primary, Buckley, Peter T., additional, O’Malley, Aidan, additional, Sause, William E., additional, Alonzo, Francis, additional, Lubkin, Ashira, additional, Boguslawski, Kristina M., additional, Payne, Angela, additional, Fernandez, Jeffrey, additional, Strohl, William R., additional, Whitaker, Brian, additional, Lynch, Anthony Simon, additional, and Torres, Victor J., additional

Published
2019
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9. Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.

Author

Zhenkun Ma and Lynch, Anthony Simon

Subjects
*ANTIBACTERIAL agents, *BACTERIAL diseases, *DRUG development, *ARTIFICIAL joints, *RIFAMYCINS, *DISEASES
Abstract

The clinical management of prosthetic joint infections and other persistent bacterial infections represents a major unmet medical need. The rifamycins are one of the most potent antibiotic classes against persistent bacterial infections, but bacteria can develop resistance to rifamycins rapidly and the clinical utility of the rifamycin class is typically limited to antibiotic combinations to minimize the development of resistance. To develop a better therapy against persistent bacterial infections, a series of rifamycin based bifunctional molecules were designed, synthesized, and evaluated with the goal to identify a dual-acting drug that maintains the potent activity of rifamycins against persistent pathogens and at the same time minimize the development of rifamycin resistance. TNP-2092 was identified as a drug candidate and is currently in an early stage of clinical development for the treatment of prosthetic joint infections. [ABSTRACT FROM AUTHOR]

Published
2016
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