7,996 results on '"Lynch, J"'
Search Results
2. Maternal pre-pregnancy body mass index and risk of preterm birth: a collaboration using large routine health datasets
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Cornish, R. P., Magnus, M. C., Urhoj, S. K., Santorelli, G., Smithers, L. G., Odd, D., Fraser, A., Håberg, S. E., Nybo Andersen, A. M., Birnie, K., Lynch, J. W., Tilling, K., and Lawlor, D. A.
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- 2024
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3. Safety Pharmacology Study Design and Statistics
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Foley, C. Michael, Lynch, J. J., III, Mittelstadt, S. W., Hock, Franz J., Section editor, Gralinski, Michael R., Section editor, Hock, Franz J., editor, and Pugsley, Michael K., editor
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- 2024
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4. ‘Is it time to standardise elective nephrostomies as day case procedures?’- a single-centre retrospective study
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Murali, N., Senathirajah, L., Taylor, M., Lynch, J., Tan, K., and Ali, T.
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- 2025
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5. Association Of Non-Steroidal Anti-Inflammatory Drugs On Synovitis And The Progression Of Osteoarthritis: Data From The Osteoarthritis Initiative
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Luitjens, J, Gassert, F, Joseph, G, Lynch, J, Nevitt, M, Lane, N, McCulloch, C, and Link, T
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Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Published
- 2023
6. Compound Effects Of Bmi And Sustained Depressive Symptoms On Knee Osteoarthritis Over 4 Years: Data From The Osteoarthritis Initiative
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Joseph, GB, McCulloch, CE, Nevitt, MC, Lynch, J, Lane, NE, Pedoia, V, Majumdar, S, and Link, TM
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Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Published
- 2023
7. Pincer Morphology Is A Risk Factor For Developing Radiographic Hip Osteoarthritis; Data From The World Coach Consortium
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Riedstra, NS, Van Buuren, MM, Boel, F, Ahedi, H, Arbabi, V, Arden, N, Bierma-Zeinstra, SM, Boer, CG, Cicuttini, FM, Cootes, TF, Felson, DT, Gielis, WP, Kluzek, S, Lane, NE, Lindner, C, Lynch, J, van Meurs, J, Nelson, AE, Nevitt, MC, Oei, EH, Runhaar, J, Spector, TD, Tang, J, Weinans, HH, and Agricola, R
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Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Published
- 2023
8. Acetabular Dysplasia Is A Risk Factor For Developing Radiographic Hip Osteoarthritis; Data From The World Coach Consortium
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Riedstra, NS, Boel, F, van Buuren, MM, Ahedi, H, Arbabi, V, Arden, N, Bierma-Zeinstra, SM, Boer, CG, Cicuttini, FM, Cootes, TF, Felson, DT, Gielis, WP, Kluzek, S, Lane, NE, Lindner, C, Lynch, J, van Meurs, J, Nelson, AE, Nevitt, MC, Oei, EH, Runhaar, J, Spector, TD, Tang, J, Weinans, HH, and Agricola, R
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Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Published
- 2023
9. Reliability and agreement of manual and automated morphological radiographic hip measurements
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Boel, F., Riedstra, N.S., Tang, J., Hanff, D.F., Ahedi, H., Arbabi, V., Arden, N.K., Bierma-Zeinstra, S.M.A., van Buuren, M.M.A., Cicuttini, F.M., Cootes, T.F., Crossley, K., Eygendaal, D., Felson, D.T., Gielis, W.P., Heerey, J., Jones, G., Kluzek, S., Lane, N.E., Lindner, C., Lynch, J., van Meurs, J., Nelson, A.E., Mosler, A.B., Nevitt, M.C., Oei, E.H., Runhaar, J., Weinans, H., and Agricola, R.
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- 2024
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10. THE WORLDWIDE COLLABORATION ON OSTEOARTHRITIS PREDICTION FOR THE HIP (WORLD COACH) CONSORTIUM: DESIGN AND RATIONALE OF A CONSORTIUM USING INDIVIDUAL PARTICIPANT DATA FROM PROSPECTIVE COHORT STUDIES
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van Buuren, MM, Ahedi, H, Arbabi, V, Arden, NK, Bierma-Zeinstra, SM, Boer, CG, Cicuttini, FM, Cootes, TF, Felson, DT, Gielis, WP, Jones, G, Lane, NE, Lindner, C, Lynch, J, van Meurs, JB, Nelson, AE, Nevitt, MC, Oei, EH, Riedstra, NS, Runhaar, J, Spector, TD, Tang, J, Weinans, H, and Agricola, R
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Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Published
- 2022
11. Synthesis of two-dimensional van der waals superlattices, heterostructures, and alloys from conversion of sequentially layered sub-nanometer metal films
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Motala, M.J., Zhang, X., Kumar, P., Oliveira, E.F., Benton, A., Miesle, P., Rao, R., Stevenson, P.R., Moore, D., Alfieri, A., Lynch, J., Austin, D., Post, S., Gao, G., Ma, S., Zhu, H., Wang, Z., Petrov, I., Stach, E.A., Kennedy, W.J., Vangala, S., Tour, J.M., Galvao, D.S., Jariwala, D., Muratore, C., Snure, M., Ajayan, P.M., and Glavin, N.R.
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- 2023
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12. Animal board invited review: Opportunities and challenges in using GWP* to report the impact of ruminant livestock on global temperature change
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del Prado, A., Lynch, J., Liu, S., Ridoutt, B., Pardo, G., and Mitloehner, F
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- 2023
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13. Relativistic Quantum Backflow
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Ashfaque, Johar M., Lynch, J., and Strange, P.
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Quantum Physics - Abstract
In this paper we discuss relativistic quantum backflow. The general theory of relativistic backflow is written down and it is shown that the backflow can be written as a function of a simple parameter which is defined in terms of fundamental constants and the backflow period. Backflow eigenfunctions are determined numerically for a range of values of and an explicit expression for the relativistic backflow eigenvalue in terms of the non-relativistic backflow constant is presented. Then backflow eigenvectors are fitted with some standard functions which lead to substantially higher backflow than has been found previously with fitting procedures, for some values of. In analysing the non-relativistic limit of the theory we show that this problem is one of those rare cases where the relativistic theory is intrinsically more simple than the non-relativistic theory., Comment: 14 pages
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- 2019
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14. DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort.
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Faber, BG, Baird, D, Gregson, CL, Gregory, JS, Barr, RJ, Aspden, RM, Lynch, J, Nevitt, MC, Lane, NE, Orwoll, E, Tobias, JH, and Osteoporotic Fractures in Men (MrOS) Study Research Group
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Osteoporotic Fractures in Men (MrOS) Study Research Group ,Femur Head ,Femur Neck ,Acetabulum ,Hip Joint ,Humans ,Arthralgia ,Osteoarthritis ,Hip ,Radiography ,Absorptiometry ,Photon ,Prevalence ,Odds Ratio ,Cohort Studies ,Prospective Studies ,Cross-Sectional Studies ,Principal Component Analysis ,Aged ,Male ,Femoracetabular Impingement ,Active shape modelling ,Hip shape ,Joint shape ,Aging ,Clinical Research ,Pain Research ,Chronic Pain ,Osteoporosis ,Arthritis ,Musculoskeletal ,Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Abstract
ObjectiveStatistical shape modelling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.MethodSSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).ResultsThe five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09, 1.39)] [odds ratio (OR) and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70, 0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07, 1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65, 0.83) and 0.82 (0.73, 0.93), respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76, 0.92)] and walking [0.88, (0.81, 0.95)], and to WOMAC score [0.87 (0.80, 0.93)].ConclusionsDXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.
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- 2017
15. Genetic associations of fatigue and other symptoms following breast cancer treatment: A prospective study
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Cameron, B., Webber, K., Li, H., Bennett, B.K., Boyle, F., de Souza, P., Wilcken, N., Lynch, J., Friedlander, M., Goldstein, D., and Lloyd, A.R.
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- 2021
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16. Safety Pharmacology Study Design and Statistics
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Foley, C. Michael, primary, Lynch, J. J., additional, and Mittelstadt, S. W., additional
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- 2022
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17. Simulating drifting fish aggregating device trajectories to identify potential interactions with endangered sea turtles.
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Escalle, Lauriane, Scutt Phillips, J., Lopez, J., Lynch, J. M., Murua, H., Royer, S. J., Swimmer, Y., Murua, J., Sen Gupta, Alex, Restrepo, V., and Moreno, G.
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SEA turtles ,LEATHERBACK turtle ,HAWKSBILL turtle ,MARINE debris ,MARINE pollution - Abstract
Copyright of Conservation Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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18. Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1)
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Jin, L., Jagatheesan, G., Lynch, J., Guo, L., and Conklin, D.J.
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- 2020
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19. Establishing nationally representative benchmarks of farm-gate nitrogen and phosphorus balances and use efficiencies on Irish farms to encourage improvements
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Thomas, I.A., Buckley, C., Kelly, E., Dillon, E., Lynch, J., Moran, B., Hennessy, T., and Murphy, P.N.C.
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- 2020
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20. The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative
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Antony, B, Driban, JB, Price, LL, Lo, GH, Ward, RJ, Nevitt, M, Lynch, J, Eaton, CB, Ding, C, and McAlindon, TE
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Chronic Pain ,Pain Research ,Clinical Research ,Arthritis ,Musculoskeletal ,Arthralgia ,Female ,Humans ,Knee Joint ,Magnetic Resonance Imaging ,Male ,Meniscus ,Middle Aged ,Osteoarthritis ,Knee ,Tear ,Bone marrow lesions ,Knee pain ,End-stage knee osteoarthritis ,Biomedical Engineering ,Human Movement and Sports Sciences ,Arthritis & Rheumatology ,Clinical sciences ,Sports science and exercise - Abstract
ObjectiveTo determine the association of different types of meniscal pathology with knee pain, bone marrow lesion (BML) volume, and end-stage knee osteoarthritis (esKOA).DesignParticipants were selected from an ancillary project to the Osteoarthritis Initiative (OAI) who had at least one knee with symptomatic osteoarthritis. Baseline magnetic resonance images (MRI) were evaluated for meniscal pathology using a modified International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine (ISAKOS) classification system. We collapsed 10 types of meniscal pathology into five categories: normal, intrameniscal signal, morphological deformity/extrusion (altered meniscal shape and/or extrusion but no apparent substance loss), tear, and maceration. Outcomes included Western Ontario and McMaster Universities osteoarthritis index (WOMAC) knee pain and BML volume at baseline and after 2 years. We defined the prevalence of esKOA based on a validated algorithm. We performed logistic regression and adjusted for age, sex, and body mass index (BMI).ResultsThe 463 participants (53% male) included in the analysis had mean age 63 (9.2) years, BMI 29.6 (4.6) kg/m2, and 71% had Kellgren-Lawrence grade ≥2. Morphological deformity/extrusion and maceration, but no other types of meniscal pathology, were associated with BML volume (morphological deformity/extrusion odds ratio [OR] = 2.47, 95% CI: 1.49, 4.09, maceration OR = 5.85, 95% CI: 3.40, 10.06) and change in BML volume (morphological deformity/extrusion OR = 2.17, 95% CI: 1.37, 3.45, maceration OR = 3.12, 95% CI: 1.87, 5.19). Only maceration was associated with baseline WOMAC knee pain (OR = 2.82, 95% CI: 1.79, 4.43) and prevalence of esKOA (OR = 7.53, 95% CI: 4.25, 13.31).ConclusionsBased on MRI, morphologic deformity/extrusion and maceration rather than intrameniscal signal or tear were associated with osteoarthritis severity and progression, which highlights the importance of differentiating distinct types of meniscal pathology.
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- 2017
21. The West Indies
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Lynch, J., primary
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- 2021
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22. Microbiomes as sources of emergent host phenotypes
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Lynch, J. B. and Hsiao, E. Y.
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- 2019
23. The Age of Johnson: A Scholarly Annual (Volume 24)
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Jack Lynch, J. T. Scanlan
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- 2021
24. Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
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Bengueddach, A., Tidjane, A., Tabeti, B., Behilil, C., Boudjenan-Serradj, N., Bensafir, S., Meharzi, S. E. I., Aissat, A., Ghouali, A. K., Larabi, K., Riffi, O., Kacimi, S. E. O., Mesli, S. N., Rezoug, W., Mitidieri, A., Jose, A., Pablo, C., Rodriguez, C. A., Panettiere, M. F., Barbalace, N., Juan, T., Lucena, J., Houdin, A., Fernandez, E., Lococo, J., Pedro, L., Loban, M., Vecchio, P., Grinblat, A., Carrie, A., Veracierto, F., Santillan, M., Napolitano, M., Avellaneda, N., Rosa, S. L., Gonzalez, C. M., Ferro, E., Munoz, J. P., Ventorutti, T., Cabrera, C., Carrizo, C., Mospane, C., Leiro, F., Espino, J., Trama, M., Bianchi, R., Potolicchio, A., Dindri, F., Buey, L., Lucas, N., Catalano, P., Astilleta, R., Quiroga, Y., Chwat, C., Valli, D., Alexandre, F., Martres, G., Rosato, G., Lemme, G., Romero, V., Doniquian, A. M., Pachajoa, D. A. P., Llahi, F., Fiorenza, J. M., Parodi, M., Ocana, N., Gallardo, A., Valenzuela, A., Perriello, J., Nador, R., Fermani, C., Garay, L., Blanco, P., Villalobos, S., Posner, F., Vieyra, N., Fiorito, P., Ciabattari, P., Kort, C. D., Daryanani, D., Smit, J., Gosselink, M. P., Janssen, N., Feiss, A., Lee, C. H. A., Taylor, D., Edington, J., Chen, N., Ong, W. M., Aigner, F., Moitzi, G., Gemes, G., Braumille, M., Mitteregger, M., Gerald, S., Uranitsch, S., Belarmino, A., Waha, J., Kahn, J., Treiber, M., Schemmer, P., Mikalauskas, S., Ibrahimli, A., Samadov, E., Orujova, E., Namazov, I., Alikhanli, J., Asgarov, M., Kutkut, A., Almahmeed, E., Aljawder, H., Juma, I., Johnston, K., Saeed, M. F., Khairi, S., Matovic, E., Omerasevic, M., Delibegovic, S., Hodzic, S., Rudell, A. G., Fuzari, J., Farah, J. F., Nadal, L. R. M., Dos Santos, M. B. A., Lupinacci, R. A., Pereira, T. S., Sete, A. D. S., Filho, A. L., De Souza Pires, B. L., Queiroz, F. L. D., Amaral, H. A. T., Dos Santos, M. A. M., De Miranda Silvestre, S. C., Hanan, B., Reis, C., Cassia, G., Luz, M. D., Delgado, M., Campanati, R., Silva, R., Bomfa-Barbosa, A., Alves, B. C., Costa, B. X. M., Cortes, B. G. W., Lemos, F. H. T., Arreguy-Borges, K., Silva, T. B., Assis, A., Freitas, A. H., Rezende, D., Silva, H., Alvarenga, I., Cascais, R., Silva, T., Santos, G., Pinto, H., Silva, I., Leite, L., Massahud, M., Meyer, M., Tiburcio, R., Martinez, C. A. R., Espinha, D. R., Marson, F. A. L., De Oliveira Goes, I. A., De Souza Artioli, L. M., Boschiero, M. N., Takahashi, C. Y., Oliveira, F. G. D., Lyra, H. F., De Oliveira, J. C. C., Santos, J. M. D., Gerber, M. T., Erdmann, T. R., Barbosa, A., Fernandes, A., Junior, A. N., Junior, H. M., Moreira, J., Ribeiro, M., Moreira, P., Carvalho, A., Santos, B., Fidelis, F., Cruz, I., Codes, L., Aibe, R., Boudoux, S., Favacho, B. C., Pinto, F., Gava, G., Pivati, I. R., Vilain, L. F., Kim, N., Nunes, R. L., Dimitrov, D., Peneva, K., Karamanliev, M., Dimitrova, S., Ivanov, T., Atanasov, B., Dzharov, G., Shtereva, M., Slavchev, M., Belev, N., Krastev, P., Arabadzhiev, A., Tonova, D., Tzoneva, D., Sokolov, M., Gribnev, P., Maslyankov, S., Pavlov, V., Bakmaz, B., Dijan, E., Coza, I., Mihanovic, J., Kucic, J., Sulen, N., Katusic, Z., Hudacek, K., Farkasova, M., Markova, M., Grolich, T., Kala, Z., Pazdirek, F., Hoch, J., Filipova, L., Kocian, P., Prikryl, P., Hogn, A., Moller, B., Slot, D. K., Baelum, J. K., Cour, K. L., Ellebaek, M. B., Eriksen, N. D., Mahmoud, A., Abdellatif, A., Nafea, A., Ewedah, M., Soliman, M., Yakout, N., Argawy, O., Sallam, I., Kamel, I., Sherif, M., Ashmawy, S., Ali, A., Saad, M., Ahmed, M., Mohamed, M., Mohamed, N., Mahmoud, S., Rashed, A. M., Abd-Errazik, M. A., Ammar, M. A., Mohammed, R., Ebrahem, A., Aal, A. A. E., Abdou, K., Wagdy, M., Qassem, M., Taha, M., El-Wafa, Y. A., Shehta, A., Metwally, A. E., Hamed, H., Ali, M. A., Elrefai, M., Sorogy, M. E., Abdelkhalek, M., Ragab, A., Refky, B., Metwally, I. H., Kamal, M., Zuhdy, M., Shetiwy, M., Sakr, A., Elfallal, A., Elfeki, H., Eldakroury, I., Elbahrawy, K., Mostafa, M., Emile, S., Tessema, A., Tasew, A., Gezahegn, H., Bekele, K., Belay, M., Gudisa, Z., Teferu, Z., Vayrynen, A., Kechagias, A., Turunen, A., Katunin, J., Parhiala, M., Pengerma, P., Lahti, P., Carpelan, A., Vihervaara, H., Huhtinen, H., Pasonen, J., Heino, R., Pakarinen, S., Falenius, V., Pinard, B., Nobile, C., Duchalais, E., Drissi, F., Meurette, G., Podevin, J., Lepenndu, M., Hoetzel, A., Jud, A., Jauch, D., Stefan, F. -F., Neeff, H., Holzner, P., Nguyen, P., Ryl, A., Kehl, F., Pullig, F., Baral, J., Munch, S., Futterer, C., Reissfelder, C., Sandra-Petrescu, F., Herrle, F., Hardt, J., Lamm, L., Seyfried, S., Gharbi, A., Aydin, F., Stavrou, G., Sperber, J., Deken, J. D., Schwarzkopf, K., Widyaningsih, R., Polidorou, A., Mpakas, A., Tokidis, E., Loun, L., Petropoulou, T., Balalis, D., Korkolis, D., Manatakis, D., Assimakopoulou, E., Bourazani, M., Gklavas, A., Kalamara, E., Papaconstantinou, I., Theodoraki, K., Chardalias, L., Konstadoulakis, M., Theodosopoulos, T., Soulioti, E., Kavezou, F., Filippou, J., Papadoliopoulou, M., Michalopoulos, N., Vassiliu, P., Sidiropoulos, T., Charakopoulou, A., Panagiotou, A., Bouchagier, K., Kokkinakis, K., Lambridi, E., Psarologos, M., Maria, S., Giannaraki, S., Kapiris, S., Triantafyllou, A., Theodoropoulos, C., Matthaiou, G., Westzaan, N., Etelka, S., Triantafyllou, T., Schizas, D., Mpaili, E., Karydakis, L., Mpoura, M., Danassi, D., Karavokyros, I., Dimitriou, N., Livanou, X., Kikira, A., Tsourouflis, G., Tomara, N. -K., Nikiteas, N., Dorovinis, P., Garoufalia, Z., Tsiotos, G., Stamou, K., Kocka, N., Ballian, N., Kalakonas, S., Athanasakis, E., Chrysos, E., Xynos, E., Tsiaoussis, J., Papadaki, K., Xenaki, S., Nyktari, V., Sarakatsianou, C., Bompou, E., Arnaoutoglou, E., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Perivoliotis, K., Apostolidi, E., Mulita, F., Karpetas, G., Maroulis, I., Vailas, M., Petra, A., Kontis, E., Kaouras, E., Katsaros, I., Katsiaras, L., Manikis, P., Papadopoulou, T., Papadopoulos, A., Manioti, E., Zeringa, G., Katsinelis, I., Mouzakis, O., Kouki, P., Nikolaou, V., Marinis, A., Alexopoulou, K., Papadaki, M., Vederaki, S. -A., Samara, A., Giakoustidis, D., Christodoulidis, G., Bareka, M., Chatzikomnitsa, P., Tsigara, S., Papadopoulos, V., Zarzava, E., Anestiadou, E., Lydia, L., Apostolakidou, M., Ioannidis, O., Simeonidis, S., Mpitsianis, S., Futaba, K., Tam, P. T. H., Ng, S. S. M., Lau, V. N. M., Tse, W. K., Banky, B., Dolhai, E., Horvath, E., Golub, J., Marton, J., Lakatos, L., Susztak, N., Maurya, A. P., Kumawat, H., Saxena, P., Lather, R., Waindeskar, V., Khanduri, A., Goyal, L., Gupta, R., Singh, S., Saksena, A. R., Rayani, B. K., Kasula, J., Raju, K., Shah, M. M., Thammineedi, S. R., Patnaik, S. C., Rathod, D., Poonia, D. R., Vishnoi, J. R., Sharma, N., Byshetty, R., Yadav, R. K., Misra, S., Dhali, A., Dhali, G. K., Biswas, J., Ray, S., Ghose, T., Pipara, A., Singh, H. M., Roy, M. K., Desai, N., Thambudorai, R., Ishwarappagol, V., Chaturvedi, A., Verma, D., Akhtar, N., Gupta, S., Rajan, S., Tiwari, T., Kumar, V., Mahajan, A., Jain, D., Liddle, D., Jyoti, J., Haque, P. D., Jain, R., Veetil, S. K., Prem, W., Lakshminarayana, B., Veerabhadrappa, B., Poojary, P. H., Bhat, R. R. K., Mathew, S., Gupta, L., Bains, L. H., Bains, L., Kumar, M., Singh, N., Lal, P., Sharma, A., Kumar, A., Garg, L., Aggarwal, M., Jakhar, R., Bose, B., Huda, F., Thakur, N., Dhar, P., Seenivasagam, K., Prakash, S., Chaudhari, A., Shukla, A., Mahakalkar, C., Saxena, G., Mahuli, K., Kaple, M., Kshirsagar, S., Mehraj, A., Parray, F., Aziz, G., Chowdri, N., Wani, R. F., Gurcoo, S., Shah, Z., Polamreddy, B. M., Madhavan, S., Subbarayan, S., Vino, S., Aravindan, U., George, G., Harikumar, C. K., Yadev, I. P., Chisthi, M., Revathy, P. S., Sreekumar, R. C., Vijayan, V., Theodore, B., Victor, C., Jesudason, M. R., Arulappan, N., Philip, R., Mittal, R., Durai, S., Creavin, B., Cullinane, C., Davis, C., Flynn, C., Liam, D., Cooke, F., Earley, H., Mccullough, P., Neary, P., Hamilton, V., Trani, A. D., Conversano, I., Cianci, P., Petta, R., Picciariello, A., Altomare, D. F., Martines, G., Grasso, S., Moffa, S., Papagni, V., Zanoni, A., Belvedere, A., Romano, A., Croce, G. D., Tanzanu, M., Rottoli, M., Cardelli, S., Lauro, A., Sartarelli, L., Binetti, M., Cervellera, M., Tonini, V., Sanna, B., Pusceddu, E., Runfola, M., Manunza, R., Pisanu, A., Cois, A., Frongia, F., Esposito, G., Podda, M., Mura, P., Cutelle, C., Ammerata, G., Sena, G., Pignataro, M., Scozzafava, M., Mazza, M., Bruni, A., Curro, G., Hila, J., Ammendola, M., Curcio, S., Signorelli, V., Marano, A., Sasia, D., Borghi, F., Giuffrida, M. C., Bonardello, M., Palmisano, S., Testa, V., Porta, A., Scaltrini, F., Iacob, G., Gaspa, I., Guatteri, L., Coladonato, M., Zapparoli, A., Pesce, A., Feo, C. V., Pindozzi, F., Bigoni, I., Torchiaro, M., Fabbri, N., Cianchi, F., Staderini, F., Elena, F., Coratti, F., Barbato, G., Fortuna, L., Romagnoli, S., Bergamini, C., Villa, G., Cecchini, I., Martellucci, J., Izzo, M., Trafeli, M., Scheiterle, M., Manoocheehri, F., Cagnazzo, F., Spampinato, M. 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E., Anoldo, P., D'Angelo, S., Marzella, A., Scotto, B., Cuneo, D., Ascari, F., Giulino, G., Varoli, M., Laquatra, N., Fortunato, C., Marino, F., Perrone, F., Pace, M., Convertini, O., Boccia, G., Raiano, G., Nuzzo, M. M. D., Calabria, M., Peltrini, R., Castiglioni, S., Bracale, U., Cervone, C., Rega, D., Caliendo, D., Benetti, E., Delrio, P., Guarino, R., Franciscis, S. D., Coppolino, F., Romano, F. M., Selvaggi, F., Pellino, G., Sciaudone, G., Selvaggi, L., Stefano, M. D., Resendiz, A., Carosso, F., Degiuli, M., Salusso, P., Reddavid, R., Benetti, S., Callari, C., Miceli, D. D., Pardo, D., Sabatino, G., Licari, L., Lirosi, M. C., Sorce, V., Peri, A., Mori, A., Pugliese, L., Filardo, M., Nuccio, P., Dominioni, T., Giuseppina, F., Angelo, F., Raffaele, G., Michele, M., Roberto, P., Mondini, A., Muratore, A., Valentino, C., Calabro, M., Danna, R., Cremonini, C., Sbarbaro, C., Tartaglia, D., Coccolini, F., Chiarugi, M., Musetti, S., Pagani, S., Neri, C. 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K., Pcolkins, A., Sivins, A., Lobovs, D., Ancans, G., Kreice, I., Budnikova, I., Jelovskis, I., Emhareb, A., Abaidalla, A., Hammed, A., Khairallah, M., Jibreel, S. S., Mohmmad, W. A. S., Hasan, W., Venskutonis, D., Daugela, E., Dainius, E., Juocas, J., Kutkevicius, J., Vaitkute, K., Bradulskis, S., Macas, A., Pauzas, H., Jokubauskas, M., Lizdenis, P., Budrikiene, R., Saladzinskas, Z., Dulskas, A., Volkoviene, G., Makauskiene, J., Kuliavas, J., Bernotaite, V., Danys, D., Kontrimaviciute, E., Poskus, E., Kryzauskas, M., Jakubauskas, M., Poskus, T., Jotautas, V., Zakaria, A. D., Kai, M. W. P., Zainy, R. H. M., Tan, S. S., Zain, W. Z. W., Zakaria, Z., Yusoff, Z. M., Raduan, F., Sagap, I., Razali, N. Y. F., Rahman, N. A., Kanthan, S. B. C., Nie, Y. C., Azman, Z. A. M., Ang, C. W., Tang, C. Y., Poh, K. S., Ng, K., Hashim, N. M., Xavier, R., Khong, T. L., Amir, A. S., Ali, C. S. C., Yew, C. K., Henry, F., Muniandy, J., Baharom, S., Eng, S. C. R., Hu, F. S. -M., Amin-Tai, H., Jabar, M. F., Satar, M. H. S. A., Fathi, N. Q., Rao, P. S., Podesta, A. M. C., Cini, C., Psaila, J., Debono, M., Sammut, M., Spiteri, N., Andrejevic, P., Muro, A. G., Leon, B. P., Perez, J. A. V., Quinonez, J. R. A., Vera, M. T. R., Gutierrez, V. M. M., Bobadilla, B. J., Martinez, C. M., De Leon Rendon, J. L., Hererro, J. A. V., Cuichan, M. V. Y., Baez, N. F., Prevost, P. G., Hoyos-Torres, A., Ruiz-Munoz, E. A., Alvarez-Bautista, F. E., Ortiz-Mendez, G., Zamudio-Bautista, J. L., Salgado-Nesme, N., Vergara-Fernandez, O., Sanchez-Valdivieso, E., Martinez, G., Navarrete-Aleman, J., Perez-Arellano, J., Maldonado-Barron, R., Hernandez-Krauss, R., Ousadden, A., Benjelloun, E. B., Bzikha, I., Ibnmajdoub, K., Mazaz, K., Marghich, O., Touzani, S., Benkabbou, A., Souadka, A., Ahmadi, B. E., Zaari, F., Laamri, I., Majbar, M. 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M., Dudric, V., Musina, A. -M., Ristescu, A. -I., Roata, C. -E., Moglan, M., Dimofte, M. -G., Lunca, S., Iacob, S., Dychko, A., Litvin, A., Kapustina, A., Provozina, A., Anokhin, E., Zabiyaka, M., Shin, A., Djumabayev, K., Kuznetsova, M., Gordeyev, S., Kochkina, S., Mamedli, Z., Markaryan, D., Galliamov, E., Semina, E., Agapov, M., Malahov, P., Garmanova, T., Kakotkin, V., Zaycev, A., Sumbaev, A., Bedzhanyan, A., Orman, E., Petrenko, K., Bredikhin, M., Frolova, Y., Tulina, I., Bashilkina, O., Tsarkov, P., Rodimov, S., Stamov, V., Balaban, V., Alexnder, A., Yanishev, A., Rogozhev, D., Yakunina, N., Chubukova, N., Nugmanov, R., Karachun, A., Petrov, A., Domanskiy, A., Panaiotti, L., Smolina, M., Sapronova, T., Pelipas, Y., Zagaynov, E., Khrykov, G., Davidovskaja, L., Burlov, N., Mankevich, N., Tverdohlebova, T., Bogatikov, A., Lodygin, A. V., Krasnoselsky, C., Vasiukova, E. -S., Kopteyev, N. R., Ovchinnikov, T., Kashchenko, V. 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M., Rubio, I., Pascual, I., Yague, J., Alcolea, N. G., Alonso, A., Dieguez, B., Ibanez, I., Perez, J. L., Losada, M., Garcia-Conde, M. G., Hernandez, M., Blazquez-Martin, A., Vera-Mansilla, C., Mendoza-Moreno, F., Hernandez-Salvan, J., Diez-Alonso, M., Hernandez-Juara, P., Barrena-Blazquez, S., Minaya-Bravo, A. M., Galvan-Perez, A., Miguel-Mendez, C. S., Gonzalez-Gonzalez, E., Alvarez-Diez, M., Garcia-Urena, M. A., Llorente-Moreno, M., Ruiz-Lozano, C., Colas-Ruiz, E., Perez-Calvo, J., Gomila-Sanso, J. A., Alvarez-Llano, L., Serrano-Fuentes, S. C., Soto-Montesinos, C., Dedeu-Bastardas, I., Perez-Reche, I., Labro-Ciurans, M., Pardo-Lopez, S., Perez, E. G., Fernandez, I. O., Canals, L. O., Espino, P. C., Ruano, P. G., Ricardo, V., Ros, E. P., Manuel, E. M., Buleje, J. A. B., Prats, M. M. C., Banos, P. A. P., Gonzalez, P. M., Celdran, R. G., Pellicer-Franco, E. M., Valero-Navarro, G., Vicente-Villena, J. P., Martinez-Mercader, M. 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M., Leoni, C., Rossi, E., Randisi, E., Puccini, M., Buccianti, P., Balestri, R., Vasale, A. O., Crescentini, G., Ranieri, G., Sinibaldi, G. I., Biondi, Alberto, Sanesi, A. P., Vacca, C., Lorenzon, Laura, Sollazzi, Liliana, Persiani, Roberto, Pezzuto, Roberto, Ferroni, A. F., Stipa, F., Volturo, L., Moretti, M., Tierno, S. M., Marina, S., Mingoli, A., Fiori, E., Pugliese, F., Brachini, G., Carta, G., Sapienza, P., Lapolla, P., Mazzotta, E., Carannante, F., Capolupo, G. T., Masciana, G., Sica, I., Caricato, M., Antonelli, S., Fiume, D., Spoletini, D., Lisi, G., Carlini, M., Menduni, V., Arturi, A., Proietto, B., Lucia, C. D., Baldi, C., Passantino, D. G., Romeo, G., Paola, M. D., Sensi, B., Sica, G., Siragusa, L., Dauri, M., Franceschill, M., Campanelli, M., Bellato, V., Porcu, A., Garau, A. G. G., Masala, M. L., Oggianu, S., Tedde, T., Perra, T., Pazzola, V., Venezia, D. F., Roviello, F., Giacomini, G., Carbone, L., Marano, L., Verre, L., Marano, M., Ciccarese, A. A., Bagnardi, F., Shahu, J., Siciliano, W., Iacomino, A., Armellin, C., Marson, F., Zanus, G., Santoro, G. A., Paoli, M. D., Grossi, U., Sekimoto, M., Kobayashi, T., Horiguchi, A., Koike, D., Yonekura, H., Kato, H., Yoshino, K., Arakawa, S., Asano, Y., Alawneh, F., Rajab, I., Ramadan, M., Masri, M. A., Qaisi, M. A., Alsamneh, M., Mubaidin, O., Al-Jarrah, A., Ababneh, H., Khdair, K., Tawarh, T., Sabri, W., Arida, Z. A., Dzhumabekov, B., Klyshbayeva, D., Fakhradiyev, I., Ispbayeva, K., Nadyrov, M., Tanabayeva, S., Saliev, T., Jumanov, A., Aitbaeva, A., Arynov, A., Kulimbet, M., Maulenov, N., Dushimova, Z., Park, E. J., Kim, H., Kang, J., Baik, S. H., Song, Y., Kwak, H. D., Kim, J., Son, J. H., Chung, J. S., Lee, H., Baek, J. -H., Nam, K. H., Lee, W. -S., Jeon, Y., Kim, C. W., Park, S. -E., Lee, S. -H., Son, G. M., Ahn, H. M., Lee, I. Y., Kim, T. K., Pcolkins, A., Sivins, A., Lobovs, D., Ancans, G., Kreice, I., Budnikova, I., Jelovskis, I., Emhareb, A., Abaidalla, A., Hammed, A., Khairallah, M., Jibreel, S. S., Mohmmad, W. A. S., Hasan, W., Venskutonis, D., Daugela, E., Dainius, E., Juocas, J., Kutkevicius, J., Vaitkute, K., Bradulskis, S., Macas, A., Pauzas, H., Jokubauskas, M., Lizdenis, P., Budrikiene, R., Saladzinskas, Z., Dulskas, A., Volkoviene, G., Makauskiene, J., Kuliavas, J., Bernotaite, V., Danys, D., Kontrimaviciute, E., Poskus, E., Kryzauskas, M., Jakubauskas, M., Poskus, T., Jotautas, V., Zakaria, A. D., Kai, M. W. P., Zainy, R. H. M., Tan, S. S., Zain, W. Z. W., Zakaria, Z., Yusoff, Z. M., Raduan, F., Sagap, I., Razali, N. Y. F., Rahman, N. A., Kanthan, S. B. C., Nie, Y. C., Azman, Z. A. M., Ang, C. W., Tang, C. Y., Poh, K. S., Ng, K., Hashim, N. M., Xavier, R., Khong, T. L., Amir, A. S., Ali, C. S. C., Yew, C. K., Henry, F., Muniandy, J., Baharom, S., Eng, S. C. R., Hu, F. S. -M., Amin-Tai, H., Jabar, M. F., Satar, M. H. S. A., Fathi, N. Q., Rao, P. S., Podesta, A. M. C., Cini, C., Psaila, J., Debono, M., Sammut, M., Spiteri, N., Andrejevic, P., Muro, A. G., Leon, B. P., Perez, J. A. V., Quinonez, J. R. A., Vera, M. T. R., Gutierrez, V. M. M., Bobadilla, B. J., Martinez, C. M., De Leon Rendon, J. L., Hererro, J. A. V., Cuichan, M. V. Y., Baez, N. F., Prevost, P. G., Hoyos-Torres, A., Ruiz-Munoz, E. A., Alvarez-Bautista, F. E., Ortiz-Mendez, G., Zamudio-Bautista, J. L., Salgado-Nesme, N., Vergara-Fernandez, O., Sanchez-Valdivieso, E., Martinez, G., Navarrete-Aleman, J., Perez-Arellano, J., Maldonado-Barron, R., Hernandez-Krauss, R., Ousadden, A., Benjelloun, E. B., Bzikha, I., Ibnmajdoub, K., Mazaz, K., Marghich, O., Touzani, S., Benkabbou, A., Souadka, A., Ahmadi, B. E., Zaari, F., Laamri, I., Majbar, M. A., Mohsine, R., Van Berlo, C., Seuren, D., Gillissen, F., Aarts, F., Konsten, J., Van Heinsbergen, M., Schlooz, S., Naiqiso, A., Merrie, A., Varghese, C., Pugh, F., Bissett, I., Wilson, K., Mitchell, S., Dawson, C., Hill, C., Wright, D., Hubley, S., Lin, A., Jones, D., Siggins, L., Fagan, P., Wu, S., Ekwesianya, A., Nwoye, C., Agara, D., Ejiofor, G., Sundaynweke, N., Kwentoh, N., Ewah, R., Aremu, A., Ballah, A., Ningi, A., Ohia, E., Mienda, I., Aliyu, M., Oloko, N., Okunlola, A., Abiyere, H., Bolanle, O. E., Babatunde, O., Fatudimu, S., Orewole, T., Mba, E. L., Felix, M. S., Abdulfatah, M., Ibrahim, N., Masoro, U., Fakoya, A., Irabor, D., Anyadike, F., Ulasi, I., Orji, M., Afuwape, O., Ayandipo, O., Adeyeye, A., Aremu, I., Adegboye, K., Gbadegesin, P., Aminu, B., Aghadi, I. K., Makama, J. G., Joshua, S., Kache, S. A., Sheshe, A. A., Bala, A. M., Garzali, I. U., Abdullahi, M. M. M., Muhammad, N., Umar, N. A., Muhammad, S., Okoye, A., Emegoakor, C., Nwosu, C., Egwuonwu, O. A., Ekwunife, O., Amadigwe, R., Ojiakor, S., Akere, A., Okereke, C., Olaleye, O., Ige, O., Olubayo, O., Olatiilu, T., Idris, M., Shehu, A., Oluyori, D., Nwabuoku, E., Ukwubile, L., Bashir, M., Daniyan, M., Rauf, H., Ali, M., Zakaria, M., Hameed, M., Amanullah, N., Chawla, T., Waqar, U., Jamal, A., Butt, A., Kerawala, A., Samson, S., Dodhy, A. A., Gill, A. J., Malik, A., Ali, D., Mohsin, H., Afzal, M. F., Batool, S., Suleman, A., Khalid, J., Zafar, M., Dilawar, M., Janjua, M. H., Sarwar, M. Z., Naqi, S. A., Akbar, A., Afzal, A., Anwar, J., Gondal, K. M., Shaukat, M., Waheed, M., Sohail, M., Mukhtiar, N., Ammar, A. S., Hussain, A., Khan, A. N., Sarwar, A., Khan, I., Khattak, S., Oqaili, B., Saada, B., Zatari, D., Jubran, F., Hamdan, F., Emar, M., Alawi, R., Jacome, G., Insturain, I., Arauz, J., Hurtado, M., Beron, R. I., Castano, R., Cao, V. H. B., Kwiatkowski, A., Dobkowski, G., Bartosiak, K., Waledziak, M., Mozanski, M., Zadrozna, M., Kowalewski, P., Fiedziuk, A., Watroba, A., Los, A., Sitarska, M., Rzaca, M., Zawadzki, M., Czarnecki, R., Tavares, C., Santos, F., Borges, F., Real, J. C., Lima, M. J., Carlos, S., Pereira, V., Pacheco, A., Gomes, G., Pimenta, J., Elisiario, L., Jervis, M., Goncalves, V., Pedro, V., Jordao, D., Neves, F. R., Conceicao, L., Angelo, M. D., Marques, P., Saraiva, R. P., Caroco, T. V., Windels, A., Machado, A., Ribeiro, C., Velez, C., Oliveira, J., Melo, M. R., Lima, R., Pires, A., Lareiro, C., Martins, R., Revez, T., Martins, A., Cardoso, D., Alegre, I., Estevao, P., Andrade, D., Gomes, D. C., Duarte, M. J., Custodio, P., Nemesio, R. 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M., Calin, C., Simeanu, C., Ciotarla, D. C., Caltea, M., Mirica, R. M., Luca, A., Pasca, A., Vlad, C., Bonci, E. -A., Stefanescu, I., Achimas-Cadariu, P. A., Gata, V. A., Capusan, A., Petrisor, C., Dindelegan, G., Seicean, R., Scurtu, R., Bintintan, V., Fagarasan, V., Ionescu, C., Crisan, D., Zanc, L., Ene-Cocis, M. -V., Muresan, M. -S., Mihalcea, S. M., Dudric, V., Musina, A. -M., Ristescu, A. -I., Roata, C. -E., Moglan, M., Dimofte, M. -G., Lunca, S., Iacob, S., Dychko, A., Litvin, A., Kapustina, A., Provozina, A., Anokhin, E., Zabiyaka, M., Shin, A., Djumabayev, K., Kuznetsova, M., Gordeyev, S., Kochkina, S., Mamedli, Z., Markaryan, D., Galliamov, E., Semina, E., Agapov, M., Malahov, P., Garmanova, T., Kakotkin, V., Zaycev, A., Sumbaev, A., Bedzhanyan, A., Orman, E., Petrenko, K., Bredikhin, M., Frolova, Y., Tulina, I., Bashilkina, O., Tsarkov, P., Rodimov, S., Stamov, V., Balaban, V., Alexnder, A., Yanishev, A., Rogozhev, D., Yakunina, N., Chubukova, N., Nugmanov, R., Karachun, A., Petrov, A., Domanskiy, A., Panaiotti, L., Smolina, M., Sapronova, T., Pelipas, Y., Zagaynov, E., Khrykov, G., Davidovskaja, L., Burlov, N., Mankevich, N., Tverdohlebova, T., Bogatikov, A., Lodygin, A. V., Krasnoselsky, C., Vasiukova, E. -S., Kopteyev, N. R., Ovchinnikov, T., Kashchenko, V. A., Novikova, A., Terentyeva, E., Kuleshov, O., Pavlov, R., Koshel, A., Kostromitsky, D., Drozdov, E., Klokov, S., Camacho, A., Khan, F. N., Bandar, M. A., Shamim, R., Chowdhury, S., Kovacevic, B., Krdzic, I., Zdravkovic, M., Kenic, M., Milentijevic, M., Petkovic, N., Radulovic, R., Ngu, J., Teo, N. Z., Singh, P. A., Ong, S. Y., Li, S., Siew, B., Chee, C., Koh, J. J. M., Lee, K. Y., Tan, K. K., Wong, S. C., Loh, W., Pujol, A. F., Rubio, J. C., Farres, L. P., Vendrell, L. L., Del Olmo, M. I. U., Pedregosa, A. B., Galmes, C., Luckute, D., Casanova, D., Artigot, M., Guedes, X., Olivella, Y., Sarda, M. S., Toscano, M. J., Damieta, M. P., Pera, M., Goncalvez, S. A., Galvez, S. T., Ruiz, S. S., Basany, E., Marinello, F., Villarino-Villa, L., Heras, M. V. -L., Martin-Sanchez, R., Mata, R. M., Blanco-Colino, R., Otero, A., Lacy, A. M. D., Sanahuja, J. M., Bravo, R., Ferraz, T., Gonzabay, V., Gonzalez, F., Menendez, P., Del Castillo, V. C. G., Lopez-Pelaez, V. M., Silva, A. 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M., Rubio, I., Pascual, I., Yague, J., Alcolea, N. G., Alonso, A., Dieguez, B., Ibanez, I., Perez, J. L., Losada, M., Garcia-Conde, M. G., Hernandez, M., Blazquez-Martin, A., Vera-Mansilla, C., Mendoza-Moreno, F., Hernandez-Salvan, J., Diez-Alonso, M., Hernandez-Juara, P., Barrena-Blazquez, S., Minaya-Bravo, A. M., Galvan-Perez, A., Miguel-Mendez, C. S., Gonzalez-Gonzalez, E., Alvarez-Diez, M., Garcia-Urena, M. A., Llorente-Moreno, M., Ruiz-Lozano, C., Colas-Ruiz, E., Perez-Calvo, J., Gomila-Sanso, J. A., Alvarez-Llano, L., Serrano-Fuentes, S. C., Soto-Montesinos, C., Dedeu-Bastardas, I., Perez-Reche, I., Labro-Ciurans, M., Pardo-Lopez, S., Perez, E. G., Fernandez, I. O., Canals, L. O., Espino, P. C., Ruano, P. G., Ricardo, V., Ros, E. P., Manuel, E. M., Buleje, J. A. B., Prats, M. M. C., Banos, P. A. P., Gonzalez, P. M., Celdran, R. G., Pellicer-Franco, E. M., Valero-Navarro, G., Vicente-Villena, J. P., Martinez-Mercader, M. 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S., Yigit, D., Unal, N., Iflazoglu, N., Yalkin, O., Topal, S., Gulcu, B., Ozturk, E., Gumbelek, G., Terkanlioglu, S., Koklucan, A., Ince, G., Sen, M., Isik, O., Kural, S., Akesen, S., Yilmazlar, T., Sungurtekin, H., Sungurtekin, U., Vural, U., Ozgen, U., Isik, A., Onk, D., Kurnaz, E., Ozker, T. S., Ipek, A., Ferlengez, A., Erturk, C., Tatar, C., Sevik, H., Akay, O., Sensoy, O., Hayirlioglu, M. B., Aktas, S., Ozben, V., Aliyeva, Z., Mutlu, A. U., Gokay, B. V., Saracoglu, C., Aytac, E., Gulmez, M., Isik, M. U., Hacim, A., Akbas, A., Soyhan, F., Turgut, M. A., Demirgan, S., Meric, S., Altinel, Y., Baris, B., Akova, E., Kahraman, E., Kucuk, H. F., Saracoglu, K. T., Kaya, S., Lel, S., Gurbulak, E. K., Caz, E., Kostek, M., Mihmanli, M., Yazici, P., Oba, S., Kirkan, E. F., Ulgur, H. S., Kalin, M., Dinkci, M. D., Ozkan, O. F., Duzgun, O., Ozturk, S., Zengin, A. K., Askar, A., Sanli, A. N., Erginoz, E., Ozcelik, M. F., Ergun, S., Uludag, S. S., Kara, D., Yilmaz, G., Sarici, I. S., Kara, Y., Incesu, A., Arican, C., Atici, S. D., Kaya, T., Gezer, T., Kirmizi, Y., Kamer, E., Aydin, G., Namdaroglu, O., Adakaya, S., Canda, A. E., Ozzeybek, D., Coskun, N., Sokmen, S., Ozkardesler, S., Bisgin, T., Miftari, A., Caliskan, C., Akgun, E., Avseren, G., Deniz, N., Bozbiyik, O., Yoldas, T., Guresin, A., Zayakov, G., Posteki, G., Utkan, N. Z., Tatar, O. C., Akcay, O., Guler, S. A., Mantoglu, B., Demirel, E., Akin, E., Gonullu, E., Altintoprak, F., Palabiyik, O., Bayhan, Z., Ciftci, A. B., Colak, E., Aybar, E., Celik, H. K., Eraslan, H., Yemez, K., Ozbilgin, S. S., Senol, S., Gultekin, F. A., Piskin, O., Guler, O., Karadere, Y., Kakeeto, A., Oguttu, B., Sikakulya, F. K., Lule, H., Rybachuk, A., Shudrak, A., Beznosenko, A., Lisnyy, I., Rozhkova, V., Zvirych, V., Alawlaqi, D., Jamali, F. E., Balooshi, I. A., Albers, M., Ali, N. A., Church, R., Dudas, G., Wells, J., Pavlova, M., Sebastiani, S., Paterson, C., Kaushal, M., Patel, P., Panchal, S., Handa, S., Tezas, S., Zaidi, S. -N., Raj, G., Wright, J., Hallam, S., Karandikar, S., Gates, Z., Marshall, A., Thompson, A., Tennakoon, A., Rao, M., Callan, R., Tufail, S., Rajendran, G., Polisetty, K., Husain, N., Clarke, N., Naranayanasamy, S., Hallett, A., Lorejo, E., Ward, N., Antakia, R., Xanthis, A., Simillis, C., Tweedle, E., Panagiotopoulou, I., Grimes, L., Mounstephen, L., Bocancia, R., Carden, C., Lynch, J., Noveros, M. S., Shaalan, R., Khalil, T., Marshall, W., Hodge, K., Balfour, J., Mcintosh, K., Buijs, L., Potter, M. A., Yule, M., Vaughan-Shaw, P. G., Smith, S., Anderson, T., Mcdermott, F. D., Daniels, I. R., Tapp, J., Smart, N., Rajaretnam, N., Bethune, R., Clark, T., Delimpalta, C., Liao, C., Banham, G., Induruwage, L., Velchuru, V., Lawrence, A., Rahman, A., Bennett, J., Badawi, M., Harshen, R., Bhargava, A., Gorrela, K., Jumah, M., Venn, M., Hanson, M., Arya, S., Atendido, T., Shrestha, A., Cook, E., Rakhimov, I., Collins, J., Alamin, N., Vigneswaran, N., Basnyat, P., Shamardal, A., Chacko, A., Wanshantha, D., Bisheet, G., Ebdewi, H., Abdellatif, M., Adu-Poku, P., Tore, A., Adams, F., Allen, K., Ahmed, K., Kulkarni, N., Chitnis, A., Patel, H., Magsino, J., Sarodaya, V., Minicozzi, A., Dempsy, C., Ahmed, H., Jayasinghe, J. D., Okail, M. H., Thaha, M., Hallworth, S., Parmar, C., Chua, L., Pizanias, M., Samin, R., Young, T., Sagar, J., Yorkmui, L., Cirocchi, N., Ahmed, S., Barreda, S. C., Kudchadkar, S., Baker, A., Jayasankar, B., Balasubramaniam, D., Jackson, J., Abdelsaid, K., Hassan, M., Shetty, S., Coldwell, C., Davies, E., Nader, H., Raistrick, M., Ryska, O., Hawkin, P., Raymond, T., Witjes, C., Steen, K. V. D., Crabtree, N., Boyce, S., Somera, W., Woodward, A., Ryan, K., Kassai, M., Aleem, M., Ghosh, A., Rixson, D., Lewis, E., Lynch, N., Shovelton, C., Zywicka, E., Guest, F., Barton, J., Purnell, R., Bamford, R., Teare, T., Adams, B., Chmielewski, G., Smith, I., Smith, L., Connolly, L., Niblett, R., Singh, A., Halliwell, G., Paraoan, M., Doree, N., Asaad, P., Kilbride, C., Carpenter, H., Wilson, J., Fletcher, J., Vijayagopal, K. A., Abbakar, M., Zaimis, T., Walsh, A., Kubisz-Pudelko, A. A., Nono, J., Pippard, L., Chowdhary, M., Dalton, R., Moussa, T., Dominguez, F., Solla, G., Curbelo, J., Laurini, M., Viola, M., Brito, N., Al-Alnsi, A., Al-Naggar, H., Saryah, L., Al-Shehari, M., Alsayadi, R., Al-Hutheifi, R., Shream, S., Biondi A. (ORCID:0000-0002-2470-7858), Lorenzon L. (ORCID:0000-0001-6736-0383), Sollazzi L. (ORCID:0000-0002-2973-6236), Persiani R. (ORCID:0000-0002-1537-5097), and Pezzuto R.
- Abstract
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.Methods: The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.Results: A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31
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- 2024
25. A randomised controlled phase II trial to examine the feasibility of using hyper-oxygenated fatty acids (HOFA) to prevent facial pressure injuries from medical devices among adults admitted to intensive care-A research protocol.
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Hunt, L, Ingleman, J, Brennen, K, Armstrong, K, Hazell, M, Keith, N, Bickford, B, Sanchez, D, Khalil, S, Geering, S, Sigdel, SA, Skaria, S, Prabhakaran, S, Lynch, J, Alexandrou, E, Drury, P, Tran, T, Frost, SA, Hunt, L, Ingleman, J, Brennen, K, Armstrong, K, Hazell, M, Keith, N, Bickford, B, Sanchez, D, Khalil, S, Geering, S, Sigdel, SA, Skaria, S, Prabhakaran, S, Lynch, J, Alexandrou, E, Drury, P, Tran, T, and Frost, SA
- Abstract
One in three patients admitted to intensive care will sustain a pressure injury (PI) from a medical device. These injuries are painful and when on the face, head or neck they can result in permanent disfigurement. Preliminary evidence of the efficacy of hyper-oxygenated fatty acids (HOFAs) to prevent facial pressure injuries from medical devices is promising; however, the feasibility of incorporating HOFAs into current standard care to prevent PI from a medical device of the face, head and neck has not been extensively explored. It is intended that the findings from this phase II feasibility study will inform the design of a larger phase III trial, by addressing two primary aims: (1) to assess the feasibility of incorporating HOFAs into standard care to prevent device-related pressure ulcers of the skin associated with the face, head and neck assess the feasibility and (2) efficacy preliminary effectiveness of HOFA. This feasibility study is an investigator-initiated mixed method study incorporating a multi-centre randomised controlled trial of using HOFAs as an adjunct to standard pressure injury prevention and care, compared with standard care alone to prevent facial, head or neck from medical devices among adults admitted to intensive care. The primary outcome of interest is the incidence of facial, head or neck pressure injuries during the first 14 days in intensive care. Secondary outcomes include PI staging, medical device exposure and intensive care and hospital outcomes. The primary analysis will be undertaken using Cox's Proportional Hazards model, and due to the exploratory nature of this phase II trial, efficacy will be based on a one-sided p-value for superiority set at 0.10. Type I and Type II error rates are set at 20%; therefore, a total sample size of 196 study participants is planned. To explore the feasibility of incorporating HOFA into usual care and to design a larger phase III trial, we will aim to interview between 10 and 20 nurses across parti
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- 2024
26. Reliability and agreement of manual and automated morphological radiographic hip measurements
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ORT Research, Other research (not in main researchprogram), MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Boel, F., Riedstra, N. S., Tang, J., Hanff, D. F., Ahedi, H., Arbabi, V., Arden, N. K., Bierma-Zeinstra, S. M.A., van Buuren, M. M.A., Cicuttini, F. M., Cootes, T. F., Crossley, K., Eygendaal, D., Felson, D. T., Gielis, W. P., Heerey, J., Jones, G., Kluzek, S., Lane, N. E., Lindner, C., Lynch, J., van Meurs, J., Nelson, A. E., Mosler, A. B., Nevitt, M. C., Oei, E. H., Runhaar, J., Weinans, H., Agricola, R., ORT Research, Other research (not in main researchprogram), MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Boel, F., Riedstra, N. S., Tang, J., Hanff, D. F., Ahedi, H., Arbabi, V., Arden, N. K., Bierma-Zeinstra, S. M.A., van Buuren, M. M.A., Cicuttini, F. M., Cootes, T. F., Crossley, K., Eygendaal, D., Felson, D. T., Gielis, W. P., Heerey, J., Jones, G., Kluzek, S., Lane, N. E., Lindner, C., Lynch, J., van Meurs, J., Nelson, A. E., Mosler, A. B., Nevitt, M. C., Oei, E. H., Runhaar, J., Weinans, H., and Agricola, R.
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- 2024
27. Maternal pre-pregnancy body mass index and risk of preterm birth:a collaboration using large routine health datasets
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Cornish, R P, Magnus, M C, Urhoj, S K, Santorelli, G, Smithers, L G, Odd, D, Fraser, A, Håberg, S E, Nybo Andersen, A M, Birnie, K, Lynch, J W, Tilling, K, Lawlor, D A, Cornish, R P, Magnus, M C, Urhoj, S K, Santorelli, G, Smithers, L G, Odd, D, Fraser, A, Håberg, S E, Nybo Andersen, A M, Birnie, K, Lynch, J W, Tilling, K, and Lawlor, D A
- Abstract
BACKGROUND: Preterm birth (PTB) is a leading cause of child morbidity and mortality. Evidence suggests an increased risk with both maternal underweight and obesity, with some studies suggesting underweight might be a greater factor in spontaneous PTB (SPTB) and that the relationship might vary by parity. Previous studies have largely explored established body mass index (BMI) categories. Our aim was to compare associations of maternal pre-pregnancy BMI with any PTB, SPTB and medically indicated PTB (MPTB) among nulliparous and parous women across populations with differing characteristics, and to identify the optimal BMI with lowest risk for these outcomes.METHODS: We used three UK datasets, two USA datasets and one each from South Australia, Norway and Denmark, together including just under 29 million pregnancies resulting in a live birth or stillbirth after 24 completed weeks gestation. Fractional polynomial multivariable logistic regression was used to examine the relationship of maternal BMI with any PTB, SPTB and MPTB, among nulliparous and parous women separately. The results were combined using a random effects meta-analysis. The estimated BMI at which risk was lowest was calculated via differentiation and a 95% confidence interval (CI) obtained using bootstrapping.RESULTS: We found non-linear associations between BMI and all three outcomes, across all datasets. The adjusted risk of any PTB and MPTB was elevated at both low and high BMIs, whereas the risk of SPTB was increased at lower levels of BMI but remained low or increased only slightly with higher BMI. In the meta-analysed data, the lowest risk of any PTB was at a BMI of 22.5 kg/m 2 (95% CI 21.5, 23.5) among nulliparous women and 25.9 kg/m 2 (95% CI 24.1, 31.7) among multiparous women, with values of 20.4 kg/m 2 (20.0, 21.1) and 22.2 kg/m 2 (21.1, 24.3), respectively, for MPTB; for SPTB, the risk remained roughly largely constant above a BMI of around 25-30 kg/m 2 regardless of parity.
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- 2024
28. Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis Study (MOST)
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Sheehy, L, Culham, E, McLean, L, Niu, J, Lynch, J, Segal, NA, Singh, JA, Nevitt, M, and Cooke, TDV
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Biomedical and Clinical Sciences ,Health Sciences ,Clinical Sciences ,Sports Science and Exercise ,Arthritis ,Pain Research ,Osteoarthritis ,Aging ,Biomedical Imaging ,Musculoskeletal ,Female ,Humans ,Knee ,Male ,Middle Aged ,Osteoarthritis ,Knee ,Radiography ,Reproducibility of Results ,Severity of Illness Index ,Knee osteoarthritis ,Knee radiographs ,Grading ,Validity ,Sensitivity to change ,Biomedical Engineering ,Human Movement and Sports Sciences ,Arthritis & Rheumatology ,Clinical sciences ,Sports science and exercise - Abstract
ObjectivesThe purpose of this study was to assess the concurrent validity and sensitivity to change of three knee osteoarthritis (OA) grading scales. The Kellgren-Lawrence (KL) and the Osteoarthritis Research Society International (OARSI) joint space narrowing (JSN) grading scales are well-established. The third scale, the compartmental grading scale for OA (CG) is a novel scale which grades JSN, femoral osteophytes, tibial erosion and subluxation to create a total score.MethodsOne sample of 72 posteroanterior (PA) fixed-flexion radiographs displaying mild to moderate knee OA was selected from the Multicenter Osteoarthritis Study (MOST) to study validity. A second sample of 75 radiograph pairs, which showed an increase in OA severity over 30 months, was selected to study sensitivity to change. The three radiographic grading scales were applied to each radiograph in both samples. Spearman's rank correlation coefficients were used to correlate the radiographic grades and the change in grades over 30 months with a Whole-organ Magnetic Resonance Imaging Score (WORMS)-based composite score which included five articular features of knee OA.ResultsCorrelations between the KL, OARSI JSN and CG grading scales and the magnetic resonance image (MRI)-based score were 0.836, 0.840 and 0.773 (P < 0.0001) respectively while correlations between change in the radiographic grading scales and change in the MRI-based score were 0.501, 0.525 and 0.492 (P < 0.0001).ConclusionsAll three radiographic grading scales showed high validity and are suitable to assess knee OA severity. They showed moderate sensitivity to change; therefore caution should be taken when using ordinal radiographic grading scales to monitor knee OA over time.
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- 2015
29. Severe radiographic knee osteoarthritis – does Kellgren and Lawrence grade 4 represent end stage disease? – the MOST study
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Guermazi, A, Hayashi, D, Roemer, F, Felson, DT, Wang, K, Lynch, J, Amin, S, Torner, J, Lewis, CE, and Nevitt, MC
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Clinical Research ,Biomedical Imaging ,Arthritis ,Musculoskeletal ,Aged ,Bone Marrow ,Cartilage ,Articular ,Female ,Humans ,Knee Joint ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Osteoarthritis ,Knee ,Radiography ,Severity of Illness Index ,Synovitis ,End-stage ,Osteoarthritis ,MRI ,Knee ,Biomedical Engineering ,Clinical Sciences ,Human Movement and Sports Sciences ,Arthritis & Rheumatology - Abstract
ObjectiveTo determine what MRI-detectable osteoarthritis features that are not visualized on radiography demonstrate progression longitudinally in Kellgren and Lawrence (KL) grade 4 knees.MethodsWe studied subjects from the Multicenter Osteoarthritis Study who had KL grade 4 knees at baseline and had baseline and 30-month MRI. Cartilage damage, bone marrow lesions (BMLs), meniscal damage, synovitis (signal changes in Hoffa fat pad), and effusion (fluid equivalent signal in the joint cavity) were semiquantitatively scored using the Whole Organ MRI Score (WORMS) system in five subregions of the medial and lateral tibiofemoral (TF) compartments. Analysis was performed for the compartment showing bone-on-bone appearance ("index") on radiograph and also for the other TF compartment of the same knee. Synovitis and effusion were assessed for the whole knee. Changes in scores at follow-up were noted for each feature. For cartilage and BML, within-grade changes were also recorded.Results140 subjects (164 knees) were included (50% women, mean age 66.0 ± 8.6 years, mean BMI 30.4 ± 5.1 kg/m(2)). Longitudinally, 51 index compartments (34%) showed an increase in the sum of cartilage scores from all subregions. In the other compartment, 25% showed an increase in the sum score for cartilage damage. For BMLs in the index compartment, 50 knees (33%) showed an increase in maximum score and 32 (21%) showed a decrease. Meniscal status mostly remained stable. Effusion worsened in 36 knees (25%) and improved in 13 knees (9%). Synovitis worsened in 14 knees (10%) and improved in six knees (4%).ConclusionIn KL grade 4 knees, MRI-detected cartilage loss and fluctuation of BMLs, effusion, and synovitis occurred frequently over a 30-month period.
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- 2015
30. Search for neutral Higgs bosons decaying into four taus at LEP2
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ALEPH Collaboration, Schael, S., Barate, R., Brunelière, R., De Bonis, I., Decamp, D., Goy, C., Jézéquel, S., Lees, J. -P., Martin, F., Merle, E., Minard, M. -N., Pietrzyk, B., Bravo, B. Trocmé S., Casado, M. P., Chmeissani, M., Crespo, J. M., Fernandez, E., Fernandez-Bosman, M., Garrido, Ll., Martinez, M., Pacheco, A., Ruiz, H., Colaleo, A., Creanza, D., De Filippis, N., de Palma, M., Iaselli, G., Maggi, G., Maggi, M., Nuzzo, S., Ranieri, A., Raso, G., Ruggieri, F., Selvaggi, G., Silvestris, L., Tempesta, P., Tricomi, A., Huang, G. Zito X., Lin, J., Ouyang, Q., Wang, T., Xie, Y., Xu, R., Xue, S., Zhang, J., Zhang, L., Zhao, W., Abbaneo, D., Barklow, T., Buchmüller, O., Cattaneo, M., Clerbaux, B., Drevermann, H., Forty, R. W., Frank, M., Gianotti, F., Hansen, J. B., Harvey, J., Hutchcroft, D. E., Janot, P., Jost, B., Kado, M., Mato, P., Moutoussi, A., Ranjard, F., Rolandi, L., Schlatter, D., Teubert, F., Valassi, A., Monteil, I. Videau S., Pallin, D., Pascolo, J. M., Perret, P., Hansen, J. D., Hansen, J. R., Hansen, P. H., Kraan, A. C., Kyriakis, B. S. Nilsson A., Markou, C., Simopoulou, E., Vayaki, A., Blondel, K. Zachariadou A., Brient, J. -C., Machefert, F., Rougé, A., Videau, H., Ciulli, V., Focardi, E., Parrini, G., Antonelli, A., Antonelli, M., Bencivenni, G., Bossi, F., Capon, G., Cerutti, F., Chiarella, V., Laurelli, P., Mannocchi, G., Murtas, G. P., Passalacqua, L., Kennedy, J., Lynch, J. G., Negus, P., O'Shea, V., Thompson, A. S., Cavanaugh, R., Dhamotharan, S., Geweniger, C., Hanke, P., Hepp, V., Kluge, E. E., Putzer, A., Stenzel, H., Tittel, K., Wunsch, M., Beuselinck, R., Cameron, W., Davies, G., Dornan, P. J., Girone, M., Marinelli, N., Nowell, J., Rutherford, S. A., Sedgbeer, J. K., Thompson, J. C., White, R., Ghete, V. M., Girtler, P., Kneringer, E., Kuhn, D., Rudolph, G., Bouhova-Thacker, E., Bowdery, C. K., Clarke, D. P., Ellis, G., Finch, A. J., Foster, F., Hughes, G., Jones, R. W. L., Pearson, M. R., Robertson, N. A., Sloan, T., Smizanska, M., van der Aa, O., Delaere, C., Leibenguth, G., Blumenschein, V. Lemaitre U., Hölldorfer, F., Jakobs, K., Kayser, F., Müller, A. -S., Renk, B., Sander, H. -G., Schmeling, S., Wachsmuth, H., Zeitnitz, C., Bonissent, T. Ziegler A., Coyle, P., Curtil, C., Ealet, A., Fouchez, D., Payre, P., Tilquin, A., Ragusa, F., David, A., Dietl, H., Ganis, G., Hüttmann, K., Lütjens, G., Moser, W. Männer H. -G., Settles, R., Villegas, M., Wolf, G., Beacham, J., Yavin, K. Cranmer I., Boucrot, J., Callot, O., Davier, M., Duflot, L., Grivaz, J. -F., Heusse, Ph., Jacholkowska, A., Serin, L., Veille, J. -J., Azzurri, P., Bagliesi, G., Boccali, T., Foà, L., Giammanco, A., Giassi, A., Ligabue, F., Messineo, A., Palla, F., Sanguinetti, G., Sciabà, A., Sguazzoni, G., Spagnolo, P., Tenchini, R., Venturi, A., Awunor, P. G. Verdini O., Blair, G. A., Cowan, G., Garcia-Bellido, A., Green, M. G., Medcalf, T., Misiejuk, A., Strong, J. A., Teixeira-Dias, P., Clifft, R. W., Edgecock, T. R., Norton, P. R., Tomalin, I. R., Bloch-Devaux, J. J. Ward B., Boumediene, D., Colas, P., Fabbro, B., Lançon, E., Lemaire, M. -C., Locci, E., Perez, P., Rander, J., Tuchming, B., Vallage, B., Litke, A. M., Taylor, G., Booth, C. N., Cartwright, S., Combley, F., Hodgson, P. N., Lehto, M., Thompson, L. F., Böhrer, A., Brandt, S., Grupen, C., Hess, J., Ngac, A., Borean, G. Prange C., Giannini, G., He, H., Putz, J., Rothberg, J., Armstrong, S. R., Berkelman, K., Ferguson, D. P. S., Gao, Y., González, S., Hayes, O. J., Hu, H., Jin, S., Kile, J., McNamara III, P. A., Nielsen, J., Pan, Y. B., von Wimmersperg-Toeller, J. H., Wiedenmann, W., Wu, J., Wu, Sau Lan, Wu, X., Zobernig, G., and Dissertori, G.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
A search for the production and non-standard decay of a Higgs boson, h, into four taus through intermediate pseudoscalars, a, is conducted on 683 pb-1 of data collected by the ALEPH experiment at centre-of-mass energies from 183 to 209 GeV. No excess of events above background is observed, and exclusion limits are placed on the combined production cross section times branching ratio, \xi^2 = \sigma(e+e- --> Zh)/\sigma_{SM}(e+e- --> Zh) x B(h --> aa)x B(a --> \tau^+\tau^-)^2. For mh < 107 GeV/c2 and 4 < ma < 10 GeV/c2, \xi^2 > 1 is excluded at the 95% confidence level., Comment: 18 pages, 16 figures
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- 2010
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31. Characteristics of new onset pediatric type 1 and 2 diabetes in San Antonio from 2019 to 2021
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Vosberg, A, primary, Khan, M, additional, Lynch, J, additional, Guerra, J, additional, and Agha, G, additional
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- 2024
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32. Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative
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Wang, K., Ding, C., Hannon, M.J., Chen, Z., Kwoh, C.K., Lynch, J., and Hunter, D.J.
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- 2018
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33. Lipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes
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McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Foster, S., Galvin, B., Hannon, T., Kriska, A., Marcus, M., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Levitt Katz, Lorraine E., Bacha, Fida, Gidding, Samuel S., Weinstock, Ruth S., El ghormli, Laure, Libman, Ingrid, Nadeau, Kristen J., Porter, Kristin, and Marcovina, Santica
- Published
- 2018
- Full Text
- View/download PDF
34. Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment – data from the Osteoarthritis Initiative
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Wirth, W, Nevitt, M, Le Graverand, M-P Hellio, Lynch, J, Maschek, S, Hudelmaier, M, Eckstein, F, and Group, for the OA Initiative Investigators
- Subjects
Biomedical and Clinical Sciences ,Health Sciences ,Clinical Sciences ,Sports Science and Exercise ,Aging ,Arthritis ,Osteoarthritis ,Musculoskeletal ,Aged ,Cartilage ,Articular ,Disease Progression ,Female ,Femur ,Humans ,Knee Joint ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Osteoarthritis ,Knee ,Predictive Value of Tests ,Prognosis ,Tibia ,Magnetic resonance imaging ,Knee osteoarthritis ,Lateral joint space narrowing ,Cartilage loss ,cartilage thickness ,OA Initiative Investigators Group ,Biomedical Engineering ,Human Movement and Sports Sciences ,Arthritis & Rheumatology ,Clinical sciences ,Sports science and exercise - Abstract
ObjectiveTo determine the predictive value of unicompartimental joint space narrowing (JSN) for MRI-based cartilage thickness loss in the narrowed and the non-narrowed femorotibial compartment.Methods922 knees from 922 Osteoarthritis Initiative (OAI) participants (62.2 ± 9.0 years, 61% females) with radiographic OA (158 without JSN [noJSN], 175 with lateral JSN [latJSN], 589 with medial JSN [medJSN]) were analyzed using 3 T MRI. One-year cartilage thickness change was determined in the lateral (LFTC) and medial femorotibial compartment (MFTC), and in femorotibial subregions. The probability of subsequent cartilage loss was calculated using predefined thresholds. The predictive value of JSN for the probability and magnitude of cartilage loss was compared between latJSN, medJSN and noJSN knees using Fisher's exact and Mann-Whitney-U tests.ResultsThe probability of cartilage loss was greater in the narrowed compartment of latJSN/medJSN knees (34.9%/32.4%) than in noJSN knees (13.3%/12.7%, P ≤ 6.4 × 10(-6)) and so was the magnitude of cartilage thickness change (P ≤ 8.2 × 10(-6)). No significant differences were observed between the narrowed compartments of latJSN vs. medJSN knees (probability: P = 0.58, magnitude: P = 0.19) or between the non-narrowed compartment of latJSN/medJSN vs. noJSN knees (probability: P ≥ 0.35, magnitude: P = ≥0.23). These results were confirmed by the location-independent ordered value (OV) analyses of femorotibial subregions.ConclusionThe predictive value of latJSN for lateral compartment cartilage loss was comparable to that of medJSN for medial compartment cartilage loss, whereas cartilage loss in the non-narrowed compartment was similar to that in noJSN knees. These findings provide important clues to predicting progression of knee OA, and in tailoring inclusion criteria for clinical trials.
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- 2014
35. Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study
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Dolling, David I, Dunn, David T, Sutherland, Katherine A, Pillay, Deenan, Mbisa, Jean L, Parry, Chris M, Post, Frank A, Sabin, Caroline A, Cane, Patricia A, Aitken, Celia, Asboe, David, Webster, Daniel, Cane, Patricia, Castro, Hannah, Dunn, David, Dolling, David, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Delpech, Valerie, Geretti, Anna Maria, Goldberg, David, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mackie, Nicola, Orkin, Chloe, Rice, Philip, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Tong, William, Williams, Ian, Zhang, Hongyi, Zuckerman, Mark, Greatorex, Jane, Wildfire, Adrian, O'Shea, Siobhan, Mullen, Jane, Mbisa, Tamyo, Cox, Alison, Tandy, Richard, Hale, Tony, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Hay, Phillip, Rice, Phillip, Paynter, Mary, Bibby, David, Kirk, Stuart, MacLean, Alasdair, Gunson, Rory, Coughlin, Kate, Fearnhill, Esther, Fradette, Lorraine, Porter, Kholoud, Ainsworth, Jonathan, Anderson, Jane, Babiker, Abdel, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Nelson, Mark, Palfreeman, Adrian, Post, Frank, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Huntington, Susie, Jose, Sophie, Thornton, Alicia, Glabay, Adam, Orkin, C, Garrett, N, Lynch, J, Hand, J, de Souza, C, Fisher, M, Perry, N, Tilbury, S, Gazzard, B, and Nelson, M
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Infectious Diseases ,Antimicrobial Resistance ,Clinical Research ,Infection ,Adult ,Anti-HIV Agents ,Atazanavir Sulfate ,Cohort Studies ,Drug Resistance ,Viral ,Female ,HIV Infections ,HIV Protease ,HIV-1 ,Humans ,Male ,Medication Adherence ,Middle Aged ,Mutation Rate ,Mutation ,Missense ,Oligopeptides ,Pyridines ,Treatment Failure ,United States ,UK HIV Drug Resistance Database ,UK Collaborative HIV Cohort Study ,HIV ,drug resistance mutations ,naive patients ,protease inhibitors ,virological failure ,Microbiology ,Pharmacology and Pharmaceutical Sciences ,Clinical sciences ,Pharmacology and pharmaceutical sciences - Abstract
ObjectivesTo determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir.MethodsResistance tests on patients failing atazanavir, conducted as part of routine clinical care in a multicentre observational study, were randomly matched by subtype to resistance tests from PI-naive controls to account for natural polymorphisms. Mutations from the consensus B sequence across the protease region were analysed for association and defined using the IAS-USA 2011 classification list.ResultsFour hundred and five of 2528 (16%) patients failed therapy containing atazanavir as a first PI over a median (IQR) follow-up of 1.76 (0.84-3.15) years and 322 resistance tests were available for analysis. Recognized major atazanavir mutations were found in six atazanavir-experienced patients (P < 0.001), including I50L and N88S. The minor mutations most strongly associated with atazanavir experience were M36I, M46I, F53L, A71V, V82T and I85V (P < 0.05). Multiple novel mutations, I15S, L19T, K43T, L63P/V, K70Q, V77I and L89I/T/V, were also associated with atazanavir experience.ConclusionsViral failure on atazanavir-containing regimens was not common and major resistance mutations were rare, suggesting that adherence may be a major contributor to viral failure. Novel mutations were described that have not been previously documented.
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- 2013
36. Present and future nitrogen deposition to national parks in the United States: critical load exceedances
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Ellis, R. A, Jacob, D. J, Sulprizio, M. P, Zhang, L., Holmes, C. D, Schichtel, B. A, Blett, T., Porter, E., Pardo, L. H, and Lynch, J. A
- Subjects
Atmospheric Nitrogen ,Climate-Change ,Adjoint Model ,Air-Quality ,Emissions ,Ammonia ,Sulfur ,Thresholds ,Management ,Vegetation - Published
- 2013
37. Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials
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Collard, HR, Yow, E, Richeldi, L, Anstrom, KJ, Glazer, C, Schwarz, M, Zisman, DA, Hunninghake, G, Chapman, J, Olman, M, Lubell, S, Morrison, LD, Steele, MP, Haram, T, Roman, J, Perez, R, Perez, T, Ryu, JH, Utz, JP, Limper, AH, Daniels, CE, Meiras, K, Walsh, S, Brown, KK, Bair, C, Kervitsky, D, Lasky, JA, Ditta, S, De Andrade, J, Thannickal, VJ, Stewart, M, Lynch, J, Calahan, E, Lopez, P, King, TE, Golden, JA, Wolters, PJ, Jeffrey, R, Noth, I, Hogarth, DK, Sandbo, N, Strek, ME, White, SR, Brown, C, Garic, I, Maleckar, S, Martinez, FJ, Flaherty, KR, Han, M, Moore, B, Toews, GB, Dahlgren, D, Raghu, G, Hayes, J, Snyder, M, Loyd, JE, Lancaster, L, Lawson, W, Greer, R, Mason, W, Kaner, RJ, Monroy, V, Wang, M, Lynch, DA, Colby, T, Becker, RC, Eisenstein, EL, MacIntyre, NR, Rochon, J, Sundy, JS, Davidson-Ray, L, Dignacco, P, Edwards, R, Anderson, R, Beci, R, Calvert, S, Cain, K, Gentry-Bumpass, T, Hill, D, Ingham, M, Kagan, E, Kaur, J, Matti, C, McClelland, J, Meredith, A, Nguyen, T, Pesarchick, J, Roberts, RS, Tate, W, Thomas, T, Walker, J, Whelan, D, Winsor, J, Yang, Q, and Reynolds, HY
- Abstract
Background: Acute exacerbation of idiopathic pulmonary fibrosis has become an important outcome measure in clinical trials. This study aimed to explore the concept of suspected acute exacerbation as an outcome measure.Methods: Three investigators retrospectively reviewed subjects enrolled in the Sildenafil Trial of Exercise Performance in IPF who experienced a respiratory serious adverse event during the course of the study. Events were classified as definite acute exacerbation, suspected acute exacerbation, or other, according to established criteria.Results: Thirty-five events were identified. Four were classified as definite acute exacerbation, fourteen as suspected acute exacerbation, and seventeen as other. Definite and suspected acute exacerbations were clinically indistinguishable. Both were most common in the winter and spring months and were associated with a high risk of disease progression and short-term mortality.Conclusions: In this study one half of respiratory serious adverse events were attributed to definite or suspected acute exacerbations. Suspected acute exacerbations are clinically indistinguishable from definite acute exacerbations and represent clinically meaningful events. Clinical trialists should consider capturing both definite and suspected acute exacerbations as outcome measures. © 2013 Collard et al.; licensee BioMed Central Ltd.
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- 2013
38. Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months
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Segal, NA, Kern, AM, Anderson, DD, Niu, J, Lynch, J, Guermazi, A, Torner, JC, Brown, TD, Nevitt, M, and Group, for the Multicenter Osteoarthritis Study
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Biomedical Imaging ,Clinical Research ,Arthritis ,Pain Research ,Chronic Pain ,Prevention ,Musculoskeletal ,Aged ,Bone Marrow ,Bone Marrow Diseases ,Cartilage ,Articular ,Cohort Studies ,Disease Progression ,Female ,Finite Element Analysis ,Humans ,Knee Joint ,Longitudinal Studies ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Osteoarthritis ,Knee ,Predictive Value of Tests ,Prognosis ,Risk Factors ,Stress ,Mechanical ,Weight-Bearing ,Joint loading ,Biomechanics ,Osteoarthritis ,Bone marrow lesions ,Cartilage loss ,Multicenter Osteoarthritis Study Group ,Biomedical Engineering ,Human Movement and Sports Sciences ,Arthritis & Rheumatology ,Clinical sciences ,Sports science and exercise - Abstract
ObjectiveAs cartilage loss and bone marrow lesions (BMLs) are associated with knee joint pain and structural worsening, this study assessed whether non-invasive estimates of articular contact stress may longitudinally predict risk for worsening of knee cartilage morphology and BMLs.DesignThis was a longitudinal cohort study of adults aged 50-79 years with risk factors for knee osteoarthritis. Baseline and follow-up measures included whole-organ magnetic resonance imaging score (WORMS) classification of knee cartilage morphology and BMLs. Tibiofemoral geometry was manually segmented on baseline magnetic resonance imaging (MRI), and three-dimensional (3D) tibiofemoral point clouds were registered into subject-specific loaded apposition using fixed-flexion knee radiographs. Discrete element analysis (DEA) was used to estimate mean and peak contact stresses for the medial and lateral compartments. The association of baseline contact stress with worsening cartilage and BMLs in the same subregion over 30 months was assessed using conditional logistic regression.ResultsSubjects (N = 38, 60.5% female) had a mean ± standard deviation (SD) age and body mass index (BMI) of 63.5 ± 8.4 years and 30.5 ± 3.7 kg/m2 respectively. Elevated mean articular contact stress at baseline was associated with worsening cartilage morphology and worsening BMLs by 30 months, with odds ratio (OR) [95% confidence interval (CI)] of 4.0 (2.5, 6.4) and 6.6 (2.7, 16.5) respectively. Peak contact stress also was significantly associated with worsening cartilage morphology and BMLs {1.9 (1.5, 2.3) and 2.3 (1.5, 3.6)}(all P < 0.0001).ConclusionsDetection of higher contact stress 30 months prior to structural worsening suggests an etiological role for mechanical loading. Estimation of articular contact stress with DEA is an efficient and accurate means of predicting subregion-specific knee joint worsening and may be useful in guiding prognosis and treatment.
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- 2012
39. Management of airway obstruction
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Lynch, J. and Crawley, S.M.
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- 2018
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40. Insulin Sensitivity and Diabetic Kidney Disease in Children and Adolescents With Type 2 Diabetes: An Observational Analysis of Data From the TODAY Clinical Trial
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McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Levitt Katz, L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S.M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O’Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Bjornstad, Petter, Nehus, Edward, El ghormli, Laure, Bacha, Fida, Libman, Ingrid M., McKay, Siripoom, Willi, Steven M., Laffel, Lori, Arslanian, Silva, and Nadeau, Kristen J.
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- 2018
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41. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study
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McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Levitt Katz, L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S.M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Levitt Katz, Lorraine E., Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, and Lima, Joao A.C.
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- 2018
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42. RWD29 Development of a Comprehensive List of Immunosuppressive Therapies to Enable a Multi-Data Source Global Real-World Effectiveness (RWE) Program of Immunocompromised Patients
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Kamauu, A.W., primary, Parker, C.G., additional, Shields, A., additional, Glaser, L., additional, DuVall, S., additional, Haidar, G., additional, Lynch, J., additional, Kamauu, A.G., additional, Taylor, S., additional, and Talarico, C., additional
- Published
- 2023
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43. Durability of viral suppression with first-line antiretroviral therapy in patients with HIV in the UK: an observational cohort study
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Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Dunn, David, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hill, Teresa, Johnson, Margaret, Jose, Sophie, Kegg, Stephen, Leen, Clifford, Martin, Fabiola, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Sabin, Caroline, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Trevelion, Roy, Walsh, John, Glabay, A, Perry, N, Tilbury, S, Youssef, E, Churchill, D, Gazzard, B, Nelson, M, Everett, R, Asboe, D, Mandalia, S, Post, F, Korat, H, Taylor, C, Gleisner, Z, Ibrahim, F, Campbell, L, Gilson, R, Brima, N, Williams, I, Johnson, M, Youle, M, Lampe, F, Smith, C, Tsintas, R, Chaloner, C, Hutchinson, S, Sabin, C, Phillips, A, Hill, T, Jose, S, Thornton, A, Huntington, S, Walsh, J, Mackie, N, Winston, A, Weber, J, Ramzan, F, Carder, M, Orkin, C, Lynch, J, Hand, J, de Souza, C, Anderson, J, Munshi, S, Ainsworth, J, Schwenk, A, Miller, S, Wood, C, Leen, C, Wilson, A, Morris, S, Gompels, M, Allan, S, Palfreeman, A, Memon, K, Lewszuk, A, Chadwick, D, Cope, E, Gibson, J, Kegg, S, Main, P, Mitchell, S, Hunter, M, Dhillon, M, Martin, F, Russell-Sharpe, S, Harte, A, Clay, S, Tariq, A, Spencer, H, Jones, R, Pritchard, J, Cumming, S, Atkinson, C, Delpech, V, O'Connor, Jemma, Smith, Colette, Lampe, Fiona C, Johnson, Margaret A, Chadwick, David R, Winston, Alan, Post, Frank A, and Phillips, Andrew N
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- 2017
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44. Effectiveness of Municipal Waste Compost and Its Humic Fraction in Suppressing Pythium ultimum
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Pascual, J. A., Garcia, C., Hernandez, T., and Lynch, J. M.
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- 2002
45. Effect of 2,4-Diacetylphloroglucinol Producing, Overproducing, and Nonproducing Pseudomonas fluorescens F113 in the Rhizosphere of Pea
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Lynch, J. M.
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- 2001
46. The contribution of conservation areas to urban sustainability
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Lynch, J., primary and Doak, J., additional
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- 2019
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47. Substrate Concentration and Plasmid Transfer Frequency between Bacteria in a Model Rhizosphere
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Pearce, D. A., Bazin, M. J., and Lynch, J. M.
- Published
- 2000
48. Do poverty and wealth look the same the world over? A comparative study of 12 cities from five high-income countries using street images
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Suel, E, Muller, E, Bennett, J, Blakely, T, Doyle, Y, Lynch, J, Mackenbach, J, Middel, A, Mizdrak, A, Nathvani, R, Brauer, M, Ezzati, M, Epidemiology and Data Science, and APH - Health Behaviors & Chronic Diseases
- Abstract
Urbanization and inequalities are two of the major policy themes of our time, intersecting in large cities where social and economic inequalities are particularly pronounced. Large scale street-level images are a source of city-wide visual information and allow for comparative analyses of multiple cities. Computer vision methods based on deep learning applied to street images have been shown to successfully measure inequalities in socioeconomic and environmental features, yet existing work has been within specific geographies and have not looked at how visual environments compare across different cities and countries. In this study, we aim to apply existing methods to understand whether, and to what extent, poor and wealthy groups live in visually similar neighborhoods across cities and countries. We present novel insights on similarity of neighborhoods using street-level images and deep learning methods. We analyzed 7.2 million images from 12 cities in five high-income countries, home to more than 85 million people: Auckland (New Zealand), Sydney (Australia), Toronto and Vancouver (Canada), Atlanta, Boston, Chicago, Los Angeles, New York, San Francisco, and Washington D.C. (United States of America), and London (United Kingdom). Visual features associated with neighborhood disadvantage are more distinct and unique to each city than those associated with affluence. For example, from what is visible from street images, high density poor neighborhoods located near the city center (e.g., in London) are visually distinct from poor suburban neighborhoods characterized by lower density and lower accessibility (e.g., in Atlanta). This suggests that differences between two cities is also driven by historical factors, policies, and local geography. Our results also have implications for image-based measures of inequality in cities especially when trained on data from cities that are visually distinct from target cities. We showed that these are more prone to errors for disadvantaged areas especially when transferring across cities, suggesting more attention needs to be paid to improving methods for capturing heterogeneity in poor environment across cities around the world.
- Published
- 2023
- Full Text
- View/download PDF
49. Effect of Introduced Pseudomonas fluorescens Strains on Soil Nematode and Protozoan Populations in the Rhizosphere of Wheat and Pea
- Author
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Lynch, J. M.
- Published
- 1999
50. Effects of Pseudomonas fluorescens F113 on Ecological Functions in the Pea Rhizosphere Are Dependent on pH
- Author
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Lynch, J. M.
- Published
- 1999
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