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3. Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes.

Author

Russell, Steven, Beck, Roy, Damiano, Edward, El-Khatib, Firas, Ruedy, Katrina, Balliro, Courtney, Li, Zoey, Calhoun, Peter, Wadwa, R, Buckingham, Bruce, Zhou, Keren, Daniels, Mark, Raskin, Philip, White, Perrin, Lynch, Jane, Pettus, Jeremy, Hirsch, Irl, Goland, Robin, Buse, John, Kruger, Davida, Mauras, Nelly, Muir, Andrew, McGill, Janet, Cogen, Fran, Weissberg-Benchell, Jill, Sherwood, Jordan, Castellanos, Luz, Hillard, Mallory, Tuffaha, Marwa, Putman, Melissa, Sands, Mollie, Forlenza, Gregory, Slover, Robert, Messer, Laurel, Cobry, Erin, Shah, Viral, Polsky, Sarit, Lal, Rayhan, Ekhlaspour, Laya, Hughes, Michael, Basina, Marina, Hatipoglu, Betul, Olansky, Leann, Bhangoo, Amrit, Forghani, Nikta, Kashmiri, Himala, Sutton, Francoise, Choudhary, Abha, Penn, Jimmy, Jafri, Rabab, Rayas, Maria, Escaname, Elia, Kerr, Catherine, Favela-Prezas, Ruby, Trikudanathan, Subbulaxmi, Williams, Kristen, Leibel, Natasha, Kirkman, M, Bergamo, Kate, Klein, Klara, Dostou, Jean, Machineni, Sriram, Young, Laura, Diner, Jamie, Bhan, Arti, Jones, J, Benson, Matthew, Bird, Keisha, Englert, Kimberly, Permuy, Joe, Cossen, Kristina, Felner, Eric, Salam, Maamoun, Silverstein, Julie, Adamson, Samantha, Cedeno, Andrea, Meighan, Seema, Dauber, Andrew, and Boeder, Schafer

Subjects
Adolescent, Adult, Aged, Bionics, Blood Glucose, Blood Glucose Self-Monitoring, Child, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Insulin Aspart, Insulin Infusion Systems, Insulin Lispro, Middle Aged, Young Adult
Abstract

BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring). The primary outcome was the glycated hemoglobin level at 13 weeks. The key secondary outcome was the percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter; the prespecified noninferiority limit for this outcome was 1 percentage point. Safety was also assessed. RESULTS: A total of 219 participants 6 to 79 years of age were assigned to the bionic-pancreas group, and 107 to the standard-care group. The glycated hemoglobin level decreased from 7.9% to 7.3% in the bionic-pancreas group and did not change (was at 7.7% at both time points) in the standard-care group (mean adjusted difference at 13 weeks, -0.5 percentage points; 95% confidence interval [CI], -0.6 to -0.3; P

Published
2022

4. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial

Author

Bardymova, Tatiana, Barrientos Perez, Margarita, Bethin, Kathleen, Bjornstad, Petter, Bondar, Irina, Chen, Mimi, Choi, Jin-Ho, Clements, Mark A, Colomar, Javier Ricardo, Daniels, Mark, Deerochanawong, Chaicharn, Desai, Vivek S, Desmangles, Jean-Claude G, Dillon, Robert G, Dixit, Naznin M, Du, Hongwei, Edelen, Rachel, Espinoza Peralta, Diego, Felipe Gacioppo, María Verónica, Ferraz, Tania Maria Bulcão Lousada, Galkina, Galina, Gallagher, Mary Patricia, George, Minu, Gonzalez, Edgar, Gottschalk, Michael Everett, Guido, Giancarlo, Hassan, Amir Ali, Hershkovitz, Eli, Huerta-Saenz, Lina P, Hwang, Jin Soon, Ibarra Gomez, Jaime Orlando, Irizarry Gonzalez, Lydia, Jain, Nina, Jelley, David H, Kim, Ho-Seong, Kovalenko, Tatiana, Laffel, Lori Michelle B, Leichter, Steven B, Liberatore Jr, Raphael Del Roio, Lynch, Jane, Mahmud, Farid Hussain, Malievskiy, Oleg Arturovich, Muir, Andrew, Nelson, Bryce A, Nevarez Ruiz, Luis Alejandro, Olson, Micah L, Pelayo Orozco, Emilia Susana, Peterkova, Valentina, Ramírez Mendoza, Fernando Ramón, Reddy, Konda Mohan, Rodriguez, Henry, Saenz, Javier Andres, Samoilova, Julia, Schwab, Karl-Otfried, Shah, Sejal H, Shehadeh, Naim, Shoemaker, Ashley H, Skorodok, Yulia, Sobolev, Aleksandr, Solís, Silvana Ernestina, Srinivasan, Shylaja, Tamborlane, William V, Tsalikian, Eva, Valeeva, Farida, Vance, Carl D, Velasquez-Mieyer, Pedro A, Violante Ortiz, Rafael Margarito, Votyakova, Olga, Wei, Haiyan, Weinstock, Ruth S, Wheeler, Mark D, Wicklow, Brandy Alexandra, Willi, Steven M, Wintergerst, Kupper A, Wolf, Risa M, Wood, Jamie Ruth, Yaliwal, Chandan, Yupanqui Lozno, Hernán, Laffel, Lori M, Danne, Thomas, Klingensmith, Georgeanna J, Willi, Steven, Zeitler, Philip, Neubacher, Dietmar, and Marquard, Jan

Published
2023
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7. WCN24-606 PROTEOMIC ANALYSIS UNCOVERS NEW CIRCULATING PROTEINS ASSOCIATED WITH INCIDENT HYPERTENSION OVER 15 YEARS IN YOUTH WITH TYPE 2 DIABETES

Author

Narongkiatikhun, Phoom, primary, Choi, Ye Ji, additional, Tommerdahl, Kalie, additional, Sharma, Kumar, additional, Waikar, Sushrut, additional, de Boer, Ian, additional, Cara-Fuentes, Gabriel, additional, Lynch, Jane, additional, Ophascharoensuk, Vuddhidej, additional, Heerspink, Hiddo, additional, Johnson, Richard, additional, Daniels, Stephen, additional, Nelson, Robert, additional, Pyle, Laura, additional, and Bjornstad, Petter, additional

Published
2024
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11. Configuring the strategic orientation of manufacturing firms for economic sustainability : a study of the UK touring caravan industry

Author

Lynch, Jane

Subjects
658.7, HC Economic History and Conditions, HD Industries. Land use. Labor, TS Manufactures
Abstract

The main purpose of this research is to examine the role of strategic orientation for effective supply chain management (SCM). A form of strategic orientation which focusses on a process-base, supply chain orientation (SCO) has already been established as a pre-requisite for SCM (Mentzer et al. 2001; Min and Mentzer, 2004, Esper et al. 2010) but as a key concept, SCO research is less developed than SCM. This research contributes to fulfilling this shortfall by identifying SCO as a multiple construct requiring the alignment of three other strategic orientations which are all function-based: purchasing orientation, marketing orientation and production1orientation. This study investigates why it is important for an organisation to retain a configuration, meaning an alignment of strategic orientation approaches, not just to rely on one approach. Existing studies have identified that individually, these three function-based strategic orientation approaches support the necessary flows, such as product, capital and information flows, within the organisation for effective SCO and SCM. To achieve SCO, Esper et al. (2010) acknowledged the importance of managing specific behaviours, such as cooperation and trust. This study examines how these behaviours form the organisational culture to create important linkages and dependencies between purchasing orientation, market orientation and production orientation that can contribute towards achieving SCO. Utilising a case study approach, empirical evidence was gathered between 2009 and 2015 from a single industry, the UK touring caravan manufacturing industry. The UK touring caravan manufacturing industry had not previously been the focus of an academic supply chain study, thus it provided an original platform to conduct the research. The initial data collection period was between 2009 and 2011, a time when manufacturing managers were facing a period of economic hyper-turbulence. During such times, senior managers of UK manufacturing organisations struggled to align the internal business strategy with the business environment which was being shaped by multiple challenging factors: hyper-competition, economic hyper-turbulence and globalisation. Thus, there was a need for managers to go beyond the strategy level and to re-examine the way their businesses were fundamentally orientated. Systems Theory (Biology), as a single theoretical approach, has been frequently applied in supply chain research. This research explores how in order to manage a system effectively, two additional theoretical pillars; Resource Dependence Theory (Strategic Management) and Resource Based View (Strategic Management), may be relevant. These theoretical lenses underpin the investigation which is framed by three research questions:  RQ1: How does supply chain orientation support supply chain management?  RQ2: How may supply chain orientation be applied as a strategic orientation?  RQ3: What is the role of strategic orientation? This research mainly builds on the SCO study by Esper et al. (2010), acknowledged in Chapter II as the first authors to conceptualise SCO. It contributes eight new research contributions, which are offered to further develop the understanding of SCO and the concept of strategic orientation: 1. The research offers a new Strategic Orientation Pyramid framework for better understanding the components of strategic orientation. 1 Production replaces operations in manufacturing context ii 2. A new Research Model improves understanding of the likely variables for measuring SCO. 3. There are new theoretical developments in understanding the relationship between SCO and SCM by defining the role of strategic orientation in the supply chain context. 4. The case study findings from this research suggest that optimally configuring and harmonising the firm's internal function-based strategic orientations is a pre-requisite for managing SCO as an antecedent for SCM in pursuing a more sustainable competitive advantage. 5. The research proposes that in order for the manufacturing organisation to manage its supply chain effectively through SCO, the purchasing, marketing and production functions should be seen as operating interdependently. The evidence from this research suggests that this interdependence MUST be supported by specific behaviours such as trust, commitment and cooperation amongst all employees from all three strategic business functions. 6. Building on the existing purchasing literature, the purchasing function is this research has been observed as being the first area to be adversely affected during periods of economic uncertainty. Therefore, in wider context of manufacturing, the purchasing function may need to be strategically elevated and aligned with marketing and production functions to support the firm’s SCO and SCM. This would become important when managers are forced to adapt their manufacturing strategy due to variations in demand levels which affects their management of the supply chain. 7. Case study findings indicate that strategic purchasing can play an important intermediary role in smoothing over the conflicting strategies between marketing and production. 8. Similarities are found between the manufacturer’s MRPII system and SCO in that the purchasing, marketing and production functions need to be strategically aligned and coordinated to enable effective strategic planning, forecasting, managing the supply chain, ordering of the materials and implementing caravan production for meeting customer demands. In addition to these theoretical developments, the research offers four methodological contributions and gives practical guidance for managers in understanding the important role of strategic orientation, which affects the organisation’s success or failure.

Published
2015

12. Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children

Author

Mummidi, Srinivas, Farook, Vidya S., Reddivari, Lavanya, Hernandez-Ruiz, Joselin, Diaz-Badillo, Alvaro, Fowler, Sharon P., Resendez, Roy G., Akhtar, Feroz, Lehman, Donna M., Jenkinson, Christopher P., Arya, Rector, Lynch, Jane L., Canas, Jose A., DeFronzo, Ralph A., Hale, Daniel E., Blangero, John, Lopez-Alvarenga, Juan Carlos, Duggirala, Ravindranath, and Vanamala, Jairam K. P.

Published
2021
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13. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Author

McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Levitt Katz, L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S.M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Levitt Katz, Lorraine E., Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, and Lima, Joao A.C.

Published
2018
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14. Assessing the Suitability of Supplier Consortia for Public Procurement Contracts

Author

Crossley, Andrew, Lynch, Jane, Hurrell, Sue, Edwards, Rhian, Rannenberg, Kai, Editor-in-chief, Sakarovitch, Jacques, Series editor, Goedicke, Michael, Series editor, Tatnall, Arthur, Series editor, Neuhold, Erich J., Series editor, Pras, Aiko, Series editor, Tröltzsch, Fredi, Series editor, Pries-Heje, Jan, Series editor, Whitehouse, Diane, Series editor, Reis, Ricardo, Series editor, Furnell, Steven, Series editor, Furbach, Ulrich, Series editor, Gulliksen, Jan, Series editor, Rauterberg, Matthias, Series editor, Afsarmanesh, Hamideh, editor, Camarinha-Matos, Luis M., editor, and Lucas Soares, António, editor

Published
2016
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15. Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children

Author

Farook, Vidya S, Reddivari, Lavanya, Mummidi, Srinivas, Puppala, Sobha, Arya, Rector, Lopez-Alvarenga, Juan Carlos, Fowler, Sharon P, Chittoor, Geetha, Resendez, Roy G, Kumar, Birunda Mohan, Comuzzie, Anthony G, Curran, Joanne E, Lehman, Donna M, Jenkinson, Christopher P, Lynch, Jane L, DeFronzo, Ralph A, Blangero, John, Hale, Daniel E, Duggirala, Ravindranath, and Vanamala, Jairam KP

Published
2017
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16. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance

Author

He, Sijia, Ryu, Jiyoon, Liu, Juanhong, Luo, Hairong, Lv, Ying, Langlais, Paul R., Wen, Jie, Dong, Feng, Sun, Zhe, Xia, Wenjuan, Lynch, Jane L., Duggirala, Ravindranath, Nicholson, Bruce J., Zang, Mengwei, Shi, Yuguang, Zhang, Fang, Liu, Feng, Bai, Juli, and Dong, Lily Q.

Subjects
Glycoproteins -- Health aspects, Obesity -- Genetic aspects -- Complications and side effects -- Care and treatment, Insulin resistance -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

Dysregulation in adipokine biosynthesis and function contributes to obesity- induced metabolic diseases. However, the identities and functions of many of the obesity-induced secretory molecules remain unknown. Here, we report the identification of leucine-rich alpha-2-glycoprotein 1 (LRG1) as an obesity- associated adipokine that exacerbates high fat diet-induced hepatosteatosis and insulin resistance. Serum levels of LRG1 were markedly elevated in obese humans and mice compared with their respective controls. LRG1 deficiency in mice greatly alleviated diet-induced hepatosteatosis, obesity, and insulin resistance. Mechanistically, LRG1 bound with high selectivity to the liver and promoted hepatosteatosis by increasing de novo lipogenesis and suppressing fatty acid p-oxidation. LRG1 also inhibited hepatic insulin signaling by downregulating insulin receptor substrates 1 and 2. Our study identified LRG1 as a key molecule that mediates the crosstalk between adipocytes and hepatocytes in diet-induced hepatosteatosis and insulin resistance. Suppressing LRG1 expression and function may be a promising strategy for the treatment of obesity-related metabolic diseases., Introduction Adipose tissue dysfunction plays a critical role in the development of insulin resistance (IR), a major risk factor for type 2 diabetes, fatty liver diseases, and cardiovascular complication (1, [...]

Published
2021
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21. Supplementary Table 2 from Origins and Prevalence of the American Founder Mutation of MSH2

Author

Clendenning, Mark, primary, Baze, Mark E., primary, Sun, Shuying, primary, Walsh, Kyle, primary, Liyanarachchi, Sandya, primary, Fix, Dan, primary, Schunemann, Victoria, primary, Comeras, Ilene, primary, Deacon, Molly, primary, Lynch, Jane F., primary, Gong, Gordon, primary, Thomas, Brittany C., primary, Thibodeau, Stephen N., primary, Lynch, Henry T., primary, Hampel, Heather, primary, and de la Chapelle, Albert, primary

Published
2023
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22. Supplementary Figure 1 from Origins and Prevalence of the American Founder Mutation of MSH2

Author

Clendenning, Mark, primary, Baze, Mark E., primary, Sun, Shuying, primary, Walsh, Kyle, primary, Liyanarachchi, Sandya, primary, Fix, Dan, primary, Schunemann, Victoria, primary, Comeras, Ilene, primary, Deacon, Molly, primary, Lynch, Jane F., primary, Gong, Gordon, primary, Thomas, Brittany C., primary, Thibodeau, Stephen N., primary, Lynch, Henry T., primary, Hampel, Heather, primary, and de la Chapelle, Albert, primary

Published
2023
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23. Supplementary Table 1 from Origins and Prevalence of the American Founder Mutation of MSH2

Author

Clendenning, Mark, primary, Baze, Mark E., primary, Sun, Shuying, primary, Walsh, Kyle, primary, Liyanarachchi, Sandya, primary, Fix, Dan, primary, Schunemann, Victoria, primary, Comeras, Ilene, primary, Deacon, Molly, primary, Lynch, Jane F., primary, Gong, Gordon, primary, Thomas, Brittany C., primary, Thibodeau, Stephen N., primary, Lynch, Henry T., primary, Hampel, Heather, primary, and de la Chapelle, Albert, primary

Published
2023
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24. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial

Author

Laffel, Lori M, primary, Danne, Thomas, additional, Klingensmith, Georgeanna J, additional, Tamborlane, William V, additional, Willi, Steven, additional, Zeitler, Philip, additional, Neubacher, Dietmar, additional, Marquard, Jan, additional, Bardymova, Tatiana, additional, Barrientos Perez, Margarita, additional, Bethin, Kathleen, additional, Bjornstad, Petter, additional, Bondar, Irina, additional, Chen, Mimi, additional, Choi, Jin-Ho, additional, Clements, Mark A, additional, Colomar, Javier Ricardo, additional, Daniels, Mark, additional, Deerochanawong, Chaicharn, additional, Desai, Vivek S, additional, Desmangles, Jean-Claude G, additional, Dillon, Robert G, additional, Dixit, Naznin M, additional, Du, Hongwei, additional, Edelen, Rachel, additional, Espinoza Peralta, Diego, additional, Felipe Gacioppo, María Verónica, additional, Ferraz, Tania Maria Bulcão Lousada, additional, Galkina, Galina, additional, Gallagher, Mary Patricia, additional, George, Minu, additional, Gonzalez, Edgar, additional, Gottschalk, Michael Everett, additional, Guido, Giancarlo, additional, Hassan, Amir Ali, additional, Hershkovitz, Eli, additional, Huerta-Saenz, Lina P, additional, Hwang, Jin Soon, additional, Ibarra Gomez, Jaime Orlando, additional, Irizarry Gonzalez, Lydia, additional, Jain, Nina, additional, Jelley, David H, additional, Kim, Ho-Seong, additional, Kovalenko, Tatiana, additional, Laffel, Lori Michelle B, additional, Leichter, Steven B, additional, Liberatore Jr, Raphael Del Roio, additional, Lynch, Jane, additional, Mahmud, Farid Hussain, additional, Malievskiy, Oleg Arturovich, additional, Muir, Andrew, additional, Nelson, Bryce A, additional, Nevarez Ruiz, Luis Alejandro, additional, Olson, Micah L, additional, Pelayo Orozco, Emilia Susana, additional, Peterkova, Valentina, additional, Ramírez Mendoza, Fernando Ramón, additional, Reddy, Konda Mohan, additional, Rodriguez, Henry, additional, Saenz, Javier Andres, additional, Samoilova, Julia, additional, Schwab, Karl-Otfried, additional, Shah, Sejal H, additional, Shehadeh, Naim, additional, Shoemaker, Ashley H, additional, Skorodok, Yulia, additional, Sobolev, Aleksandr, additional, Solís, Silvana Ernestina, additional, Srinivasan, Shylaja, additional, Tsalikian, Eva, additional, Valeeva, Farida, additional, Vance, Carl D, additional, Velasquez-Mieyer, Pedro A, additional, Violante Ortiz, Rafael Margarito, additional, Votyakova, Olga, additional, Wei, Haiyan, additional, Weinstock, Ruth S, additional, Wheeler, Mark D, additional, Wicklow, Brandy Alexandra, additional, Willi, Steven M, additional, Wintergerst, Kupper A, additional, Wolf, Risa M, additional, Wood, Jamie Ruth, additional, Yaliwal, Chandan, additional, and Yupanqui Lozno, Hernán, additional

Published
2023
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25. Lynch Syndrome II in a Navajo Family: A Revisit

Author

Lynch, Henry T., Drouhard, Thomas, Lanspa, Stephen J., Lynch, Patrick, Bronson, Earlene, and Lynch, Jane F.

Subjects
hereditary colorectal cancer disorders, racial, environmental, homogeneity, cencer control, diagnosis
Abstract

A study of variation in cancer incidence among the Navajo Indians, given their relative racial and environmental homogeneity, could provide important clues to etiology and, ultimately, to cancer control. A family with Lynch syndrome II, which was originally described in a Navajo kindred, has received follow-up eight years later. Three at-risk relatives have had newly diagnosed colorectal cancer. These findings were highly predictable, given knowledge of the natural history and genetics of this autosomal dominantly inherited disorder. This disorder is believed to be the first example of hereditary colorectal cancer of any type among American Indians. Given the ubiquitous nature of hereditary colorectal cancer disorders, it is likely that other, similar, colorectal cancer-prone families exist among the Navajo. Biomolecular technology employing DNA analysis, when it becomes available, should aid in cancer genetic diagnosis. Meanwhile, knowledge of hereditary colon cancer’s natural history, coupled with painstaking compilation of the pedigree, will be mandated for hereditary colorectal cancer syndrome diagnosis.

Published
1992

26. Congenital Hypothyroidism: Screening and Management

Author

Rose, Susan R., primary, Wassner, Ari J., additional, Wintergerst, Kupper A., additional, Yayah-Jones, Nana-Hawa, additional, Hopkin, Robert J., additional, Chuang, Janet, additional, Smith, Jessica R., additional, Abell, Katherine, additional, LaFranchi, Stephen H., additional, Rose, Susan R., additional, Yayah Jones, Nana-Hawa, additional, Bethin, Kathleen E., additional, Bruggeman, Brittany, additional, Brodsky, Jill L., additional, Jelley, David H., additional, Marshall, Bess A., additional, Mastrandrea, Lucy D., additional, Lynch, Jane L., additional, Laskosz, Laura, additional, Burke, Leah W., additional, Geleske, Timothy A., additional, Holm, Ingrid A., additional, Introne, Wendy J., additional, Jones, Kelly, additional, Lyons, Michael J., additional, Monteil, Danielle C., additional, Pritchard, Amanda B., additional, Smith Trapane, Pamela Lyn, additional, Vergano, Samantha A., additional, Weaver, Kathryn, additional, Alexander, Aimee A., additional, C4unniff, Christopher, additional, Null, Mary E., additional, Parisi, Melissa A., additional, Ralson, Steven J, additional, and Scott, Joan, additional

Published
2022
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28. Historical Aspects of Lynch Syndrome

Author

Lynch, Henry T., Hitchins, Megan P., Shaw, Trudy G., Lynch, Jane F., Roy, Hemant, Rodriguez-Bigas, Miguel A., editor, Cutait, Raul, editor, Lynch, Patrick M., editor, Tomlinson, Ian, editor, and Vasen, Hans F.A., editor

Published
2010
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50. Hereditary Factors in Endometrial Cancer

Author

Lynch, Henry T., Casey, Murray Joseph, Knezetic, Joseph A., Shaw, Trudy G., Lynch, Jane E., Bewtra, Chhanda, Markman, Maurie, editor, Giordano, Antonio, editor, Bovicelli, Alessandro, editor, and Kurman, Robert J., editor

Published
2007
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