18 results on '"Lyndon Joseph"'
Search Results
2. Increasing Use of Cardiac and Pulmonary Rehabilitation in Traditional and Community Settings: OPPORTUNITIES TO REDUCE HEALTH CARE DISPARITIES
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Lyndon Joseph, Steven J. Keteyian, Pamela N. Peterson, Roberto P. Benzo, Daniel E. Forman, Lawton S. Cooper, Susan T. Shero, Diann E. Gaalema, Antonello Punturieri, Susan J. Zieman, Joseph Finkelstein, and Jerome L. Fleg
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,MEDLINE ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Health care ,Medicine ,Humans ,Pulmonary rehabilitation ,Healthcare Disparities ,education ,Socioeconomic status ,health care economics and organizations ,education.field_of_study ,Rehabilitation ,Cardiac Rehabilitation ,business.industry ,Health equity ,Exercise Therapy ,030228 respiratory system ,Family medicine ,Quality of Life ,Cardiology and Cardiovascular Medicine ,business - Abstract
Although both cardiac rehabilitation (CR) and pulmonary rehabilitation (PR) are recommended by clinical practice guidelines and covered by most insurers, they remain severely underutilized. To address this problem, the National Heart, Lung, and Blood Institute (NHLBI), in collaboration with the National Institute on Aging (NIA), developed Funding Opportunity Announcements (FOAs) in late 2017 to support phase II clinical trials to increase the uptake of CR and PR in traditional and community settings. The objectives of these FOAs were to (1) test strategies that will lead to increased use of CR and PR in the US population who are eligible based on clinical guidelines; (2) test strategies to reduce disparities in the use of CR and PR based on age, gender, race/ethnicity, and socioeconomic status; and (3) test whether increased use of CR and PR, whether by traditional center-based or new models, is accompanied by improvements in relevant clinical and patient-centered outcomes, including exercise capacity, cardiovascular and pulmonary risk factors, and quality of life. Five NHLBI grants and a single NIA grant were funded in the summer of 2018 for this CR/PR collaborative initiative. A brief description of the research to be developed in each grant is provided.
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- 2020
3. National Institutes of Health Research Plan on Rehabilitation
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Julia H. Rowland, Pamela McInnes, Abby G. Ershow, Ann M. O'Mara, Charles Washabaugh, Ann R. Knebel, Diane L. Damiano, Biao Tian, Sue Marden, Lana Shekim, Rosalina Bray, Lyndon Joseph, Joan McGowan, Theresa H. Cruz, Rachel M. Ballard, Thomas N. Greenwell, Grace C.Y. Peng, William N. Elwood, Cheri L. Wiggs, Alison N. Cernich, Teresa L.Z. Jones, Eve Reider, Mary Ellen Michel, Lyn B. Jakeman, David B. Shurtleff, David M. Panchinson, Jerome L. Fleg, Denise Juliano-Bult, Partap S. Khalsa, Leighton Chan, Lois A. Tully, Daofen Chen, Lisa Begg, James Panagis, Catherine Y. Spong, Louis A. Quatrano, and Ralph Nitkin
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Occupational therapy ,Gerontology ,medicine.medical_specialty ,medicine.medical_treatment ,media_common.quotation_subject ,Medical rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Plan (drawing) ,01 natural sciences ,Article ,03 medical and health sciences ,0302 clinical medicine ,Research plan ,Nursing ,medicine ,Humans ,Organizational Objectives ,Disabled Persons ,030212 general & internal medicine ,0101 mathematics ,Function (engineering) ,Neurorehabilitation ,media_common ,Medical education ,Rehabilitation ,Health Priorities ,business.industry ,Public health ,010102 general mathematics ,Rehabilitation psychology ,Stakeholder ,United States ,National Institutes of Health (U.S.) ,Work (electrical) ,Rehabilitation Research ,Psychology ,Citation ,business ,030217 neurology & neurosurgery - Abstract
One in five Americans experiences disability that affects their daily function because of impairments in mobility, cognitive function, sensory impairment, or communication impairment. The need for rehabilitation strategies to optimize function and reduce disability is a clear priority for research to address this public health challenge. The National Institutes of Health (NIH) recently published a Research Plan on Rehabilitation that provides a set of priorities to guide the field over the next 5 years. The plan was developed with input from multiple Institutes and Centers within the NIH, the National Advisory Board for Medical Rehabilitation Research, and the public. This article provides an overview of the need for this research plan, an outline of its development, and a listing of six priority areas for research. The NIH is committed to working with all stakeholder communities engaged in rehabilitation research to track progress made on these priorities and to work to advance the science of medical rehabilitation. This article is being published almost simultaneously in the following six journals: American Journal of Occupational Therapy, American Journal of Physical Medicine and Rehabilitation, Archives of Physical Medicine and Rehabilitation, Neurorehabilitation and Neural Repair, Physical Therapy, and Rehabilitation Psychology. Citation information is as follows: NIH Medical Rehabilitation Coordinating Committee. Am J Phys Med Rehabil. 2017;97(4):404—407.
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- 2017
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4. Protocol for serious fall injury adjudication in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study
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Julie Weldon, Bridget M. Mignosa, Jocelyn Wiggins, Scott Margolis, Maureen Fagan, Molly Lukas, Heather G. Allore, Obafemi Okuwobi, David Buchner, Pamela W. Duncan, Abby C. King, Jocelyn Nunez, Lawrence Garber, Jeffrey Reist, Albert W. Wu, Sajida Saeed Chaudry, Neil B. Alexander, Cindy Stowe, Kevin P. High, Rosaly Correa-de-Araujo, Haseena Rajeevan, Fred C. Ko, Nancy K. Latham, Katy Araujo, Anita Leveke, Luann Bianco, Crysta Collins, Rixin Wang, Ariela R. Orkaby, Christian Espino, Carol Gordon, Linda V. Nyquist, Lori Goehring, Rosanne M. Leipzig, La Toya Edwards, Cathy Foskett, Deborah Matza, Roxana Hirst, Mukaila Raji, Robert B. Wallace, Scott Feeser, Mary Anne Sterling, Christine Moore, David B. Reuben, Mara Abella, Michael Albert, Geraldine Hawthorne-Jones, Steven B. Clauser, Susan L. Greenspan, Bimal Ashar, Brian Funaro, Patricia C. Dykes, Bernard Birnbaum, Evan C. Hadley, Siobhan K McMahon, Denise Esserman, Erich J. Greene, Amy Shelton, Jonathan F. Bean, Thomas R. Prohaska, Joanne M. McGloin, Marcel Salive, Bonita Lynn Beattie, Sabina Rubeck, Deborah West, Ravishankar Ramaswamy, Peggy Preusse, Thomas G. Travison, Mary Anne Ferchak, Azraa Amroze, Kenneth Rando, Martha B. Carnie, Susan S. Ellenberg, Vivian Chavez, Cynthia J. Brown, Alice Lee, Patti L. Ephraim, Charles Lu, Richard Eder, Amy Larson, Terry Fulmer, Rosario Garcia, Alejandra Salazar, Janelle Howe, Laurence Z. Rubenstein, Peter Peduzzi, Yan Chen, Samuel Ho, Erica Chopskie, Sui Tang, Thomas W. Storer, Teresita Pennestri, Charles Keller, Sergei Romashkan, Taylor Christiansen, Amrish Joseph, Eleni A. Skokos, Lea Harvin, Catherine Hanson, Tiffany Campbell, Liliya Katsovich, Joseph Bianco, Stephen C. Waring, Shalender Bhasin, Kimberly Larsen, James Goodwin, Thomas M. Gill, Angela Shanahan, Allison Richards, David A. Ganz, Anne McDonald, Karen Burek, Jerry H. Gurwitz, Leo Sherman, Dorothy I. Baker, Madeline Rigatti, Albert L. Siu, Nancy Gallagher, Hilary Stenvig, Margaret Hoberg, Joseph Madia, Jeremy N. Rich, Barbara Foster, Michael Miller, Nancy P. Lorenze, Rina Castro, Katy L. B. Araujo, Carri Casteel, Lyndon Joseph, Tara Scheck, Todd M. Manini, Laurence Friedman, Karen Wu, Laura Frain, Jay Magaziner, Yvette Wells, Allise Taran, Eloisa Martinez, Jeremy D. Walston, Tina Ledesma, James Dziura, Margaret Doyle, Naaz Hussain, Lea N. Harvin, Priscilla K. Gazarian, Brooke Brawley, Charles Boult, Yuri Agrawal, Peter Charpentier, Kety Florgomes, Shehzad Basaria, Elena Volpi, Cynthia L. Stowe, David Nock, and Heather Larsen
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Physical Injury - Accidents and Adverse Effects ,Clinical Trials and Supportive Activities ,Poison control ,Suicide prevention ,Occupational safety and health ,Study Protocol ,03 medical and health sciences ,STRIDE Investigators ,0302 clinical medicine ,Clinical Research ,030225 pediatrics ,Injury prevention ,medicine ,030212 general & internal medicine ,Adjudication ,Injuries ,business.industry ,lcsh:Public aspects of medicine ,Medical record ,Head injury ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,lcsh:RA1-1270 ,Injuries and accidents ,lcsh:RC86-88.9 ,General Medicine ,Health Services ,medicine.disease ,3. Good health ,Good Health and Well Being ,Telephone interview ,Public Health and Health Services ,Falls ,Patient Safety ,Medical emergency ,business - Abstract
Background This paper describes a protocol for determining the incidence of serious fall injuries for Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE), a large, multicenter pragmatic clinical trial with limited resources for event adjudication. We describe how administrative data (from participating health systems and Medicare claims) can be used to confirm participant-reported events, with more time- and resource-intensive full-text medical record data used only on an “as-needed” basis. Methods STRIDE is a pragmatic cluster-randomized controlled trial involving 5451 participants age ≥ 70 and at increased risk for falls, served by 86 primary care practices in 10 US health systems. The STRIDE intervention involves a nurse falls care manager who assesses a participant’s underlying risks for falls, suggests interventions using motivational interviewing, and then creates, implements and longitudinally follows up on an individualized care plan with the participant (and caregiver when appropriate), in partnership with the participant’s primary care provider. STRIDE’s primary outcome is serious fall injuries, defined as a fall resulting in: (1) medical attention billable according to Medicare guidelines with a) fracture (excluding isolated thoracic vertebral and/or lumbar vertebral fracture), b) joint dislocation, or c) cut requiring closure; OR (2) overnight hospitalization with a) head injury, b) sprain or strain, c) bruising or swelling, or d) other injury determined to be “serious” (i.e., burn, rhabdomyolysis, or internal injury). Two sources of data are required to confirm a serious fall injury. The primary data source is the participant’s self-report of a fall leading to medical attention, identified during telephone interview every 4 months, with the confirmatory source being (1) administrative data capturing encounters at the participating health systems or Medicare claims and/or (2) the full text of medical records requested only as needed. Discussion Adjudication is ongoing, with over 1000 potentially qualifying events adjudicated to date. Administrative data can be successfully used for adjudication, as part of a hybrid approach that retrieves full-text medical records only when needed. With the continued refinement and availability of administrative data sources, future studies may be able to use administrative data completely in lieu of medical record review to maximize the quality of adjudication with finite resources. Trial registration ClinicalTrials.gov (NCT02475850). Electronic supplementary material The online version of this article (10.1186/s40621-019-0190-2) contains supplementary material, which is available to authorized users.
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- 2019
5. NIH's Consortium on Molecular Transducers of Physical Activity (MoTrPAC)
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John P. Williams, Lyndon Joseph, and MoTrPAC Consortium
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Engineering ,business.industry ,Genetics ,Physical activity ,business ,Molecular Biology ,Biochemistry ,Biotechnology ,Biomedical engineering - Published
- 2019
6. Molecular Transducers of Physical Activity Consortium (MoTrPAC) Progress and Study Protocol Design
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Williams John and Lyndon Joseph
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Nutrition and Dietetics ,Life span ,business.industry ,Protocol design ,Physical activity ,Medicine (miscellaneous) ,Medicine ,Computational biology ,business ,Genome ,Sports Nutrition and Physical Activity ,Food Science ,Epigenomics - Abstract
OBJECTIVES: Physical activity is beneficial to human health and wellbeing across the lifespan. The numerous benefits of regular physical activity (PA) have long been recognized. Despite this, most exercise studies are associational and the molecular mechanisms that are the bases for the beneficial effects remain obscure as are the mechanisms of multiorgan communications and benefits. MoTrPAC is a large NIH discovery project (19 grants; 37 Principal Investigators; 23 institutions) whose goals are to assemble a comprehensive map of the molecular changes that occur in response to exercise and provide insights into how they are altered by age, sex, body composition and fitness level and develop a user-friendly database to facilitate investigator-initiated studies and catalyze the field of PA research and explore hypotheses exploring novel mechanisms by which PA improves or preserves health. METHODS: This project will explore and document changes in molecules mobilized in blood, muscle and fat in humans as well as 15 additional tissues for rats in response to different aerobic and resistance exercise regimes. The human studies are a multicenter clinical trial cohort of people of both sexes from 10–80 years of age and recruitment has begun. Preclinical animal Studies (PASS) have been conducted in 6 and 18-month old F344 rats and tissues harvested from control inactive rats and rats at seven time-points following a single 30 minute acute bout of treadmill running. A separate group of rats were subjected to an intensive (70% VO2max) and progressive run training program of 5 day/week for 1,2, 4, or 8 weeks with 18 tissues collected. Multiple state of art and omics platforms including genomic, transcriptomic, epigenomic, proteomic and metabolomics are being employed to define and discover the molecules mobilized in response to exercise. RESULTS: This presentation will highlight the study protocol design and data from the initial public data release (November 15th, 2019). Data will be available to the extramural community to collaborate with the MoTrPAC investigators to explore innovative mechanisms to expand the impact of the initial studies. CONCLUSIONS: The product from this consortium will begin to characterize the molecular mechanisms of molecules identified in the ‘molecular map’ that underlie the beneficial effects of PA. FUNDING SOURCES: National Institutes of Health.
- Published
- 2020
7. Molecular Transducers of Physical Activity Consortium (MoTrPAC) Progress
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John P. Williams and Lyndon Joseph
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Engineering ,Transducer ,business.industry ,Genetics ,Physical activity ,Nanotechnology ,business ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2020
8. NIH PATHWAYS TO PREVENTION WORKSHOP: RESEARCH GAPS FOR LONG-TERM DRUG THERAPIES FOR FRACTURE PREVENTION
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Faye Chen and Lyndon Joseph
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Drug ,medicine.medical_specialty ,Health (social science) ,business.industry ,media_common.quotation_subject ,Session 3455 (Symposium) ,Health Professions (miscellaneous) ,Term (time) ,Abstracts ,medicine ,Fracture prevention ,Life-span and Life-course Studies ,Intensive care medicine ,business ,media_common - Abstract
The NIH Pathways to Prevention Workshop was held on October 30-31, 2018 to present scientific evidence, as well as physician and patient perspectives to better understand the benefits and harms of drug therapies for osteoporosis fracture prevention. Osteoporotic fractures lead to substantial morbidity, mortality, and economic costs. The underlying medical condition, is a skeletal disorder characterized by compromised bone strength predisposing to increased fracture risk. Several medications approved by the U.S. Food and Drug Administration to prevent osteoporotic fractures have been effective when taken by people who are at high risk of fracture. These include bisphosphonates , denosumab, teriparatide, estrogens, and selective estrogen-receptor modulators. However, rare but serious adverse events, such as atypical femoral fractures and osteonecrosis of the jaw associated with bisphosphonates have raised questions regarding the safety of their use. There is limited evidence on the benefits and harms of long-term osteoporosis drug therapy, including the timing and duration of drug discontinuation or drug holidays. It is not clearly known which patients will benefit or may be harmed from continued drug intervention, who should and should not be put on drug holiday, how to identify such patients and properly treat them, and how to predict their outcomes. Key scientific areas covered by the workshop included: the benefits and risks of osteoporotic drugs with short-term and long-term use and factors that influence outcomes; the impact of drug discontinuation and drug holidays on outcomes; and patient and clinician factors that impact the use of and adherence to osteoporotic drugs.
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- 2019
9. NIA HEALTH DISPARITIES RESEARCH NETWORK: APPROACHES AND FINDINGS FROM GERIATRICS AND CLINICAL GERONTOLOGY
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Lyndon Joseph and CarlV Hill
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Geriatrics ,Gerontology ,Abstracts ,medicine.medical_specialty ,Health (social science) ,business.industry ,Medicine ,Life-span and Life-course Studies ,business ,Health Professions (miscellaneous) ,Health equity ,Session 545 (Symposium) - Abstract
Health disparities are differences in the incidence, prevalence and burden of diseases, mortality rates and causes of death that exist among population groups. Health disparities are associated with a broad, complex, and interrelated array of factors that influence health, accelerate aging and reduce life expectancy. NIA’s health disparities research goals are to understand environmental and sociocultural factors and related behavioral and biological mechanisms that diminish health and reduce life expectancy for vulnerable populations, explore the biological mechanisms through which disparities influence age-related change, and identify where disparities emerge in diagnosis, prognosis or treatment in geriatric conditions. Presentations will focus on whether structural-level discrimination may be a key factor in potentiating well known race-related health disparities especially those with an accelerated onset and may be associated with MRI-indicators of subclinical brain pathology; identifying biomarkers for early detection of cognitive and functional decline in high risk subpopulations and how ethnicity influences cerebral spinal fluid and imaging biomarkers link to early identification of cognitive and functional impairment ; effects of medication management and deprescribing among African American and Hispanic older adults with Alzheimer’s disease and related dementias and multiple chronic conditions; examine the use of multi-level factors and technology to overcome the barriers to urban-rural health disparities in managing many chronic diseases such as hepatitis C virus infection and delivery of appropriate medical services; and understanding the racial and ethnic differences in the link between environmental exposures and auto-immune comorbid asthma.
- Published
- 2019
10. The genetic and environmental effects of parental age on the expression of psychopathology in adoptees
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Lyndon Joseph Aguiar
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Substance abuse ,Proband ,Secondary analysis ,medicine ,Alcohol abuse ,Antisocial personality ,medicine.disease ,Psychology ,Depression (differential diagnoses) ,Psychopathology ,Developmental psychology ,Clinical psychology - Abstract
OF THE THESIS THE GENETIC AND ENVIRONMENTAL EFFECTS OF PARENTAL AGE ON THE EXPRESSION OF PSYCHOPATHOLOGY IN ADOPTEES by Lyndon Joseph Aguiar Florida International University, 1999 Miami, Florida Professor Gordon E. Finley, Major Professor Secondary analysis of 581 adoptees was utilized to determine if parental age is related, either genetically or environmentally, to the development of psychopathology. The significant results showed that proband adoptees (with psychopathology in biologic relatives) with younger birthparents had increased alcohol abuse and those with younger birthfathers had increased antisocial personality while adoptees with older birthparents had increased depression. Analyses on control adoptees (with background free of known genetic disturbances) showed that those with younger adoptive mothers had increased antisocial personality and drug abuse and those with younger adoptive fathers had increased antisocial personality while adoptees with older adoptive fathers had increased depression.
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- 2017
11. Sedentary Behavior Research Priorities—NHLBI/NIA Sedentary Behavior Workshop Summary
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Russell R. Pate, Roger A. Fielding, Lyndon Joseph, and Josephine E. Boyington
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Gerontology ,education.field_of_study ,medicine.medical_specialty ,business.industry ,education ,Population ,Physical activity ,Alternative medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Disease ,Sedentary behavior ,Article ,medicine ,Orthopedics and Sports Medicine ,business ,Sedentary lifestyle - Abstract
Over the course of 2013, the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Aging (NIA) collaborated with a multi-national group of expert scientists to convene, host and facilitate a four-part virtual webinar workshop on sedentary behavior. Participants met to evaluate and discuss the current epidemiological, clinical and other relevant literature on sedentary behavior and to identify research priorities relative to preventing cardiovascular disease and mitigating aging-related disability and functional outcomes. The workshop was predicated on findings of insufficient levels of population adherence to current physical activity recommendations (1,12) and the need to address the NHLBI and NIA research portfolio gaps in the area of sedentary behavior.
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- 2015
12. National Institutes of Health Research Plan on Rehabilitation: NIH Medical Rehabilitation Coordinating Committee
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Ann, O'Mara, Julia H, Rowland, Thomas N, Greenwell, Cheri L, Wiggs, Jerome, Fleg, Lyndon, Joseph, Joan, McGowan, James S, Panagis, Charles, Washabaugh, Grace C Y, Peng, Rosalina, Bray, Alison N, Cernich, Theresa H, Cruz, Sue, Marden, Mary Ellen, Michel, Ralph, Nitkin, Louis, Quatrano, Catherine Y, Spong, Lana, Shekim, Teresa L Z, Jones, Denise, Juliano-Bult, David M, Panchinson, Daofen, Chen, Lyn, Jakeman, Ann, Knebel, Lois A, Tully, Leighton, Chan, Diane, Damiano, Biao, Tian, Pamela, McInnes, Partap, Khalsa, Eve, Reider, David, Shurtleff, William, Elwood, Rachel, Ballard, Abby G, Ershow, and Lisa, Begg
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National Institutes of Health (U.S.) ,Health Priorities ,Rehabilitation Research ,Special Reprint ,Humans ,Organizational Objectives ,Disabled Persons ,United States - Abstract
One in five Americans experiences disability that affects their daily function because of impairments in mobility, cognitive function, sensory impairment, or communication impairment. The need for rehabilitation strategies to optimize function and reduce disability is a clear priority for research to address this public health challenge. The National Institutes of Health (NIH) recently published a Research Plan on Rehabilitation that provides a set of priorities to guide the field over the next 5 years. The plan was developed with input from multiple Institutes and Centers within the NIH, the National Advisory Board for Medical Rehabilitation Research, and the public. This article provides an overview of the need for this research plan, an outline of its development, and a listing of six priority areas for research. The NIH is committed to working with all stakeholder communities engaged in rehabilitation research to track progress made on these priorities and to work to advance the science of medical rehabilitation. This article is being published almost simultaneously in the following six journals: American Journal of Occupational Therapy, American Journal of Physical Medicine and Rehabilitation, Archives of Physical Medicine and Rehabilitation, Neurorehabilitation and Neural Repair, Physical Therapy, and Rehabilitation Psychology. Citation information is as follows: NIH Medical Rehabilitation Coordinating Committee. Am J Phys Med Rehabil. 2017;97(4):404—407.
- Published
- 2017
13. Comparison among the perforation rates of Maloney, balloon, and Savary dilation of esophageal strictures
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Hernandez, Lyndon Joseph, Jacobson, Jerrold W., and Harris, M.Scott
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- 2000
- Full Text
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14. Workshop on Personal Motion Technologies for Healthy Independent Living: Executive Summary
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Mary M, Rodgers, Zohara A, Cohen, Lyndon, Joseph, Winifred, Rossi, and Bo, Xie
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Adult ,Male ,Gerontology ,Coping (psychology) ,medicine.medical_specialty ,Activities of daily living ,medicine.medical_treatment ,Applied psychology ,Biomedical Technology ,Alternative medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Education ,Disability Evaluation ,Activities of Daily Living ,medicine ,Humans ,Disabled Persons ,Mobility Limitation ,Biomedical technology ,Physical Therapy Modalities ,Aged ,Executive summary ,Rehabilitation ,Middle Aged ,Self-Help Devices ,United States ,Caregivers ,Needs assessment ,Quality of Life ,Female ,Independent Living ,Psychology ,Needs Assessment ,Independent living ,Forecasting - Abstract
The objective of the June 2010 "Workshop on Personal Motions Technologies for Healthy Independent Living" was to discuss personal motion technologies that might enable older adults and individuals with disability to live independently for longer periods. The 60 participants included clinicians, academic researchers, engineers, patient advocates, caregivers, members of the public, and federal representatives. The workshop was divided into 6 sessions that addressed the following: (1) use of technologies in identifying early indicators of disease or adverse events; (2) monitoring daily activities; (3) coping with impairment; (4) managing mild cognitive impairment; (5) rehabilitation and exercise in the home; and (6) caregiver support. Presentations and discussion focused on clinical needs, the health impact of addressing those needs, state-of-the-art technologies, and challenges to adoption of those technologies. Conclusions included the following: (1) Involvement of end-users in research and development will increase the likelihood that technologies will be adopted. (2) Integration of differing types of technology into a system that includes clinical measures is required for independent living. (3) Seniors are willing to sacrifice some privacy for an effective technology that keeps them in their homes as long as they control who receives their data. (4) Multilevel and multiscale models are needed to understand motion in the context of the environment and to design effective systems.
- Published
- 2012
15. Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
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Amanda T. Boyce, Mary Evans, Mary L. Garcia-Cazarin, Dan M. Cooper, Mary Roary, John P. Williams, Frank W. Booth, Deborah M. Muoio, Mary M. Rodgers, Michael B. Reid, Padma Maruvada, Jonelle K. Drugan, Jerome L. Fleg, Sue C. Bodine, Marcas M. Bamman, Lyndon Joseph, Mark P. Mattson, Maren R. Laughlin, John M. Jakicic, Joan McGowan, P. Darrell Neufer, James I. Koenig, Robert E. Gerszten, Wendy M. Kohrt, William E. Kraus, Bret H. Goodpaster, Claude Bouchard, Russell T. Hepple, Danuta Krotoski, and Richard H. Ingraham
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Knowledge management ,Physiology ,Physical activity ,Nanotechnology ,Disease ,Health benefits ,Medical Biochemistry and Metabolomics ,Motor Activity ,Health outcomes ,Cardiovascular ,Endocrinology & Metabolism ,Clinical Research ,Medicine ,Animals ,Humans ,Motor activity ,Beneficial effects ,Molecular Biology ,Clinical Trials as Topic ,business.industry ,Prevention ,Outcome measures ,Computational Biology ,Cell Biology ,Clinical trial ,Good Health and Well Being ,Health ,Biochemistry and Cell Biology ,business - Abstract
© 2015 Elsevier Inc. The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the NIH convened a workshop in late October 2014 entitled "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits." Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying "-omics" technologies to understand interorgan crosstalk and biological networking systems during PA, and the need to establish an infrastructure of clinical trial sites with sufficient expertise to incorporate mechanistic outcome measures into adequately sized human PA trials. Identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine.
- Published
- 2015
16. The genetic and environmental effects of parental age on the expression of psychopathology in adoptees
- Author
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Aguiar, Lyndon Joseph, primary
- Full Text
- View/download PDF
17. The genetic and environmental effects of parental age on the expression of psychopathology in adoptees
- Author
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Aguiar, Lyndon Joseph and Aguiar, Lyndon Joseph
- Abstract
Secondary analysis of 581 adoptees was utilized to determine if parental age is related, either genetically or environmentally, to the development of psychopathology. The significant results showed that proband adoptees (with psychopathology in biologic relatives) with younger birthparents had increased alcohol abuse and those with younger birthfathers had increased antisocial personality while adoptees with older birthparents had increased depression. Analyses on control adoptees (with background free of known genetic disturbances) showed that those with younger adoptive mothers had increased antisocial personality and drug abuse and those with younger adoptive fathers had increased antisocial personality while adoptees with older adoptive fathers had increased depression. Implications of these findings are that adoptees with both younger birth and adoptive parents are more likely to have externalizing symptoms, while adoptees with both older birth and adoptive parents are more like to have internalizing symptoms. This information is beneficial to those involved in adoption placement.
- Published
- 1999
18. Ast to alt ratio as a marker of liver cirrhosis among patients with hepatitis C
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Hernandez, Lyndon Joseph V., primary, Affi, Aboud, additional, Guda, Nalini, additional, Canga, Cristino, additional, Cohn, Jennifer, additional, Jacobson, Jerrold, additional, Puetz, Thomas R., additional, and Dindzans, Vincents J., additional
- Published
- 2000
- Full Text
- View/download PDF
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